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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:ERBB2-KAT2A (FusionGDB2 ID:27168) |
Fusion Gene Summary for ERBB2-KAT2A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ERBB2-KAT2A | Fusion gene ID: 27168 | Hgene | Tgene | Gene symbol | ERBB2 | KAT2A | Gene ID | 2064 | 2648 |
| Gene name | erb-b2 receptor tyrosine kinase 2 | lysine acetyltransferase 2A | |
| Synonyms | CD340|HER-2|HER-2/neu|HER2|MLN 19|NEU|NGL|TKR1 | GCN5|GCN5L2|PCAF-b|hGCN5 | |
| Cytomap | 17q12 | 17q21.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | receptor tyrosine-protein kinase erbB-2c-erb B2/neu proteinherstatinhuman epidermal growth factor receptor 2metastatic lymph node gene 19 proteinneuro/glioblastoma derived oncogene homologneuroblastoma/glioblastoma derived oncogene homologp185erbB2 | histone acetyltransferase KAT2AGCN5 (general control of amino-acid synthesis, yeast, homolog)-like 2General control of amino acid synthesis, yeast, homolog-like 2K(lysine) acetyltransferase 2ASTAF97general control of amino acid synthesis protein 5-li | |
| Modification date | 20200329 | 20200313 | |
| UniProtAcc | P04626 | Q92830 | |
| Ensembl transtripts involved in fusion gene | ENST00000269571, ENST00000406381, ENST00000445658, ENST00000540042, ENST00000540147, ENST00000541774, ENST00000578199, ENST00000584450, ENST00000584601, ENST00000584888, | ENST00000225916, | |
| Fusion gene scores | * DoF score | 50 X 44 X 14=30800 | 2 X 2 X 2=8 |
| # samples | 73 | 2 | |
| ** MAII score | log2(73/30800*10)=-5.39889007670225 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: ERBB2 [Title/Abstract] AND KAT2A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | ERBB2(37872192)-KAT2A(40267053), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | ERBB2-KAT2A seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. ERBB2-KAT2A seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. ERBB2-KAT2A seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF. ERBB2-KAT2A seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF. ERBB2-KAT2A seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. ERBB2-KAT2A seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ERBB2 | GO:0007165 | signal transduction | 10572067 |
| Hgene | ERBB2 | GO:0007166 | cell surface receptor signaling pathway | 9685399 |
| Hgene | ERBB2 | GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | 7514177 |
| Hgene | ERBB2 | GO:0014065 | phosphatidylinositol 3-kinase signaling | 7556068 |
| Hgene | ERBB2 | GO:0018108 | peptidyl-tyrosine phosphorylation | 12000754 |
| Hgene | ERBB2 | GO:0032886 | regulation of microtubule-based process | 20937854 |
| Hgene | ERBB2 | GO:0035556 | intracellular signal transduction | 19372587 |
| Hgene | ERBB2 | GO:0042060 | wound healing | 12646923 |
| Hgene | ERBB2 | GO:0043406 | positive regulation of MAP kinase activity | 10572067 |
| Hgene | ERBB2 | GO:0045785 | positive regulation of cell adhesion | 7556068 |
| Hgene | ERBB2 | GO:0046777 | protein autophosphorylation | 7556068 |
| Hgene | ERBB2 | GO:0050679 | positive regulation of epithelial cell proliferation | 10572067 |
| Hgene | ERBB2 | GO:0071363 | cellular response to growth factor stimulus | 20010870 |
| Hgene | ERBB2 | GO:0090314 | positive regulation of protein targeting to membrane | 20010870 |
| Tgene | KAT2A | GO:0016573 | histone acetylation | 29973595|31527837 |
| Tgene | KAT2A | GO:0016578 | histone deubiquitination | 18206972 |
| Tgene | KAT2A | GO:0018393 | internal peptidyl-lysine acetylation | 27796307|29174768 |
| Tgene | KAT2A | GO:0043966 | histone H3 acetylation | 10373431|11564863|18838386|29211711 |
| Tgene | KAT2A | GO:0045893 | positive regulation of transcription, DNA-templated | 29973595|31527837 |
| Tgene | KAT2A | GO:0045944 | positive regulation of transcription by RNA polymerase II | 29211711 |
| Tgene | KAT2A | GO:0046600 | negative regulation of centriole replication | 27796307 |
| Tgene | KAT2A | GO:0106077 | histone succinylation | 29211711 |
| Fusion gene breakpoints across ERBB2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across KAT2A (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | STAD | TCGA-BR-A4IZ | ERBB2 | chr17 | 37872192 | + | KAT2A | chr17 | 40267053 | - |
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Fusion Gene ORF analysis for ERBB2-KAT2A |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000269571 | ENST00000225916 | ERBB2 | chr17 | 37872192 | + | KAT2A | chr17 | 40267053 | - |
| Frame-shift | ENST00000406381 | ENST00000225916 | ERBB2 | chr17 | 37872192 | + | KAT2A | chr17 | 40267053 | - |
| Frame-shift | ENST00000445658 | ENST00000225916 | ERBB2 | chr17 | 37872192 | + | KAT2A | chr17 | 40267053 | - |
| Frame-shift | ENST00000540042 | ENST00000225916 | ERBB2 | chr17 | 37872192 | + | KAT2A | chr17 | 40267053 | - |
| Frame-shift | ENST00000540147 | ENST00000225916 | ERBB2 | chr17 | 37872192 | + | KAT2A | chr17 | 40267053 | - |
| Frame-shift | ENST00000541774 | ENST00000225916 | ERBB2 | chr17 | 37872192 | + | KAT2A | chr17 | 40267053 | - |
| Frame-shift | ENST00000578199 | ENST00000225916 | ERBB2 | chr17 | 37872192 | + | KAT2A | chr17 | 40267053 | - |
| Frame-shift | ENST00000584450 | ENST00000225916 | ERBB2 | chr17 | 37872192 | + | KAT2A | chr17 | 40267053 | - |
| Frame-shift | ENST00000584601 | ENST00000225916 | ERBB2 | chr17 | 37872192 | + | KAT2A | chr17 | 40267053 | - |
| intron-3CDS | ENST00000584888 | ENST00000225916 | ERBB2 | chr17 | 37872192 | + | KAT2A | chr17 | 40267053 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for ERBB2-KAT2A |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for ERBB2-KAT2A |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:37872192/:40267053) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ERBB2 | KAT2A |
| FUNCTION: Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. {ECO:0000305}.; FUNCTION: In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth. {ECO:0000269|PubMed:10358079, ECO:0000269|PubMed:15380516, ECO:0000269|PubMed:21555369}. | FUNCTION: Protein lysine acyltransferase that can act as a acetyltransferase, glutaryltransferase or succinyltransferase, depending on the context (PubMed:29211711). Acts as a histone lysine succinyltransferase: catalyzes succinylation of histone H3 on 'Lys-79' (H3K79succ), with a maximum frequency around the transcription start sites of genes (PubMed:29211711). Succinylation of histones gives a specific tag for epigenetic transcription activation (PubMed:29211711). Association with the 2-oxoglutarate dehydrogenase complex, which provides succinyl-CoA, is required for histone succinylation (PubMed:29211711). In different complexes, functions either as an acetyltransferase (HAT) or as a succinyltransferase: in the SAGA and ATAC complexes, acts as a histone acetyltransferase (PubMed:17301242, PubMed:19103755, PubMed:29211711). Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles (PubMed:17301242, PubMed:19103755). Acetylation of histones gives a specific tag for epigenetic transcription activation (PubMed:17301242, PubMed:19103755, PubMed:29211711). Recruited by the XPC complex at promoters, where it specifically mediates acetylation of histone variant H2A.Z.1/H2A.Z, thereby promoting expression of target genes (PubMed:29973595, PubMed:31527837). Involved in long-term memory consolidation and synaptic plasticity: acts by promoting expression of a hippocampal gene expression network linked to neuroactive receptor signaling (By similarity). Acts as a positive regulator of T-cell activation: upon TCR stimulation, recruited to the IL2 promoter following interaction with NFATC2 and catalyzes acetylation of histone H3 at 'Lys-9' (H3K9ac), leading to promote IL2 expression (By similarity). Required for growth and differentiation of craniofacial cartilage and bone by regulating acetylation of histone H3 at 'Lys-9' (H3K9ac) (By similarity). Regulates embryonic stem cell (ESC) pluripotency and differentiation (By similarity). Also acetylates non-histone proteins, such as CEBPB, PLK4 and TBX5 (PubMed:17301242, PubMed:27796307, PubMed:29174768). Involved in heart and limb development by mediating acetylation of TBX5, acetylation regulating nucleocytoplasmic shuttling of TBX5 (PubMed:29174768). Acts as a negative regulator of centrosome amplification by mediating acetylation of PLK4 (PubMed:27796307). Also acts as a histone glutaryltransferase: catalyzes glutarylation of histone H4 on 'Lys-91' (H4K91glu), a mark that destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes (PubMed:31542297). {ECO:0000250|UniProtKB:Q9JHD2, ECO:0000269|PubMed:17301242, ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:27796307, ECO:0000269|PubMed:29174768, ECO:0000269|PubMed:29211711, ECO:0000269|PubMed:29973595, ECO:0000269|PubMed:31527837, ECO:0000269|PubMed:31542297}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. {ECO:0000269|PubMed:11384967}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for ERBB2-KAT2A |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
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Fusion Gene PPI Analysis for ERBB2-KAT2A |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ERBB2-KAT2A |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for ERBB2-KAT2A |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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