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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ERBB2-MED1 (FusionGDB2 ID:27173)

Fusion Gene Summary for ERBB2-MED1

check button Fusion gene summary
Fusion gene informationFusion gene name: ERBB2-MED1
Fusion gene ID: 27173
HgeneTgene
Gene symbol

ERBB2

MED1

Gene ID

2064

8930

Gene nameerb-b2 receptor tyrosine kinase 2methyl-CpG binding domain 4, DNA glycosylase
SynonymsCD340|HER-2|HER-2/neu|HER2|MLN 19|NEU|NGL|TKR1MED1
Cytomap

17q12

3q21.3

Type of geneprotein-codingprotein-coding
Descriptionreceptor tyrosine-protein kinase erbB-2c-erb B2/neu proteinherstatinhuman epidermal growth factor receptor 2metastatic lymph node gene 19 proteinneuro/glioblastoma derived oncogene homologneuroblastoma/glioblastoma derived oncogene homologp185erbB2methyl-CpG-binding domain protein 43,N(4)-ethenocytosine glycosylaseG/5-fluorouracil mismatch glycosylase with biphasic kineticsG/T mismatch glycosylaseG/U mismatch glycosylasemethyl-CpG binding domain protein 4methyl-CpG-binding endonuclease 1meth
Modification date2020032920200313
UniProtAcc

P04626

A0JLT2

Ensembl transtripts involved in fusion geneENST00000269571, ENST00000406381, 
ENST00000445658, ENST00000540147, 
ENST00000541774, ENST00000578199, 
ENST00000584450, ENST00000584601, 
ENST00000540042, ENST00000584888, 
ENST00000300651, ENST00000394287, 
Fusion gene scores* DoF score50 X 44 X 14=308009 X 8 X 5=360
# samples 7310
** MAII scorelog2(73/30800*10)=-5.39889007670225
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/360*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ERBB2 [Title/Abstract] AND MED1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointERBB2(37873733)-MED1(37571592), # samples:3
Anticipated loss of major functional domain due to fusion event.ERBB2-MED1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
ERBB2-MED1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
ERBB2-MED1 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
ERBB2-MED1 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
ERBB2-MED1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneERBB2

GO:0007165

signal transduction

10572067

HgeneERBB2

GO:0007166

cell surface receptor signaling pathway

9685399

HgeneERBB2

GO:0007169

transmembrane receptor protein tyrosine kinase signaling pathway

7514177

HgeneERBB2

GO:0014065

phosphatidylinositol 3-kinase signaling

7556068

HgeneERBB2

GO:0018108

peptidyl-tyrosine phosphorylation

12000754

HgeneERBB2

GO:0032886

regulation of microtubule-based process

20937854

HgeneERBB2

GO:0035556

intracellular signal transduction

19372587

HgeneERBB2

GO:0042060

wound healing

12646923

HgeneERBB2

GO:0043406

positive regulation of MAP kinase activity

10572067

HgeneERBB2

GO:0045785

positive regulation of cell adhesion

7556068

HgeneERBB2

GO:0046777

protein autophosphorylation

7556068

HgeneERBB2

GO:0050679

positive regulation of epithelial cell proliferation

10572067

HgeneERBB2

GO:0071363

cellular response to growth factor stimulus

20010870

HgeneERBB2

GO:0090314

positive regulation of protein targeting to membrane

20010870


check buttonFusion gene breakpoints across ERBB2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MED1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-D8-A1XJ-01AERBB2chr17

37873733

+MED1chr17

37571592

-
ChimerDB4BRCATCGA-D8-A1XJERBB2chr17

37873733

+MED1chr17

37571592

-


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Fusion Gene ORF analysis for ERBB2-MED1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000269571ENST00000300651ERBB2chr17

37873733

+MED1chr17

37571592

-
Frame-shiftENST00000269571ENST00000394287ERBB2chr17

37873733

+MED1chr17

37571592

-
Frame-shiftENST00000406381ENST00000300651ERBB2chr17

37873733

+MED1chr17

37571592

-
Frame-shiftENST00000406381ENST00000394287ERBB2chr17

37873733

+MED1chr17

37571592

-
Frame-shiftENST00000445658ENST00000300651ERBB2chr17

37873733

+MED1chr17

37571592

-
Frame-shiftENST00000445658ENST00000394287ERBB2chr17

37873733

+MED1chr17

37571592

-
Frame-shiftENST00000540147ENST00000300651ERBB2chr17

37873733

+MED1chr17

37571592

-
Frame-shiftENST00000540147ENST00000394287ERBB2chr17

37873733

+MED1chr17

37571592

-
Frame-shiftENST00000541774ENST00000300651ERBB2chr17

37873733

+MED1chr17

37571592

-
Frame-shiftENST00000541774ENST00000394287ERBB2chr17

37873733

+MED1chr17

37571592

-
Frame-shiftENST00000578199ENST00000300651ERBB2chr17

37873733

+MED1chr17

37571592

-
Frame-shiftENST00000578199ENST00000394287ERBB2chr17

37873733

+MED1chr17

37571592

-
Frame-shiftENST00000584450ENST00000300651ERBB2chr17

37873733

+MED1chr17

37571592

-
Frame-shiftENST00000584450ENST00000394287ERBB2chr17

37873733

+MED1chr17

37571592

-
Frame-shiftENST00000584601ENST00000300651ERBB2chr17

37873733

+MED1chr17

37571592

-
Frame-shiftENST00000584601ENST00000394287ERBB2chr17

37873733

+MED1chr17

37571592

-
In-frameENST00000540042ENST00000300651ERBB2chr17

37873733

+MED1chr17

37571592

-
In-frameENST00000540042ENST00000394287ERBB2chr17

37873733

+MED1chr17

37571592

-
intron-3CDSENST00000584888ENST00000300651ERBB2chr17

37873733

+MED1chr17

37571592

-
intron-3CDSENST00000584888ENST00000394287ERBB2chr17

37873733

+MED1chr17

37571592

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000540042ERBB2chr1737873733+ENST00000394287MED1chr1737571592-335319861661884572
ENST00000540042ERBB2chr1737873733+ENST00000300651MED1chr1737571592-63091986196454341156

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000540042ENST00000394287ERBB2chr1737873733+MED1chr1737571592-0.0118406280.9881593
ENST00000540042ENST00000300651ERBB2chr1737873733+MED1chr1737571592-0.0078550750.9921449

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Fusion Genomic Features for ERBB2-MED1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ERBB2-MED1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:37873733/chr17:37571592)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ERBB2

P04626

MED1

A0JLT2

FUNCTION: Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. {ECO:0000305}.; FUNCTION: In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth. {ECO:0000269|PubMed:10358079, ECO:0000269|PubMed:15380516, ECO:0000269|PubMed:21555369}.FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMED1chr17:37873733chr17:37571592ENST0000030065113171078_14824321582.0Compositional biasNote=Ser-rich
TgeneMED1chr17:37873733chr17:37571592ENST0000030065113171496_15294321582.0Compositional biasNote=Lys-rich
TgeneMED1chr17:37873733chr17:37571592ENST0000039428713181078_1482432557.0Compositional biasNote=Ser-rich
TgeneMED1chr17:37873733chr17:37571592ENST0000039428713181496_1529432557.0Compositional biasNote=Lys-rich
TgeneMED1chr17:37873733chr17:37571592ENST000003006511317604_6084321582.0MotifNote=LXXLL motif 1
TgeneMED1chr17:37873733chr17:37571592ENST000003006511317645_6494321582.0MotifNote=LXXLL motif 2
TgeneMED1chr17:37873733chr17:37571592ENST000003006511317875_9024321582.0MotifIntegrase domain-binding motif (IBM)
TgeneMED1chr17:37873733chr17:37571592ENST000003942871318604_608432557.0MotifNote=LXXLL motif 1
TgeneMED1chr17:37873733chr17:37571592ENST000003942871318645_649432557.0MotifNote=LXXLL motif 2
TgeneMED1chr17:37873733chr17:37571592ENST000003942871318875_902432557.0MotifIntegrase domain-binding motif (IBM)

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneERBB2chr17:37873733chr17:37571592ENST00000269571+1527720_9876321256.0DomainProtein kinase
HgeneERBB2chr17:37873733chr17:37571592ENST00000541774+1527720_9876171241.0DomainProtein kinase
HgeneERBB2chr17:37873733chr17:37571592ENST00000269571+1527676_6896321256.0MotifNote=Nuclear localization signal
HgeneERBB2chr17:37873733chr17:37571592ENST00000541774+1527676_6896171241.0MotifNote=Nuclear localization signal
HgeneERBB2chr17:37873733chr17:37571592ENST00000269571+1527726_7346321256.0Nucleotide bindingATP
HgeneERBB2chr17:37873733chr17:37571592ENST00000541774+1527726_7346171241.0Nucleotide bindingATP
HgeneERBB2chr17:37873733chr17:37571592ENST00000269571+152723_6526321256.0Topological domainExtracellular
HgeneERBB2chr17:37873733chr17:37571592ENST00000269571+1527676_12556321256.0Topological domainCytoplasmic
HgeneERBB2chr17:37873733chr17:37571592ENST00000541774+152723_6526171241.0Topological domainExtracellular
HgeneERBB2chr17:37873733chr17:37571592ENST00000541774+1527676_12556171241.0Topological domainCytoplasmic
HgeneERBB2chr17:37873733chr17:37571592ENST00000269571+1527653_6756321256.0TransmembraneHelical
HgeneERBB2chr17:37873733chr17:37571592ENST00000541774+1527653_6756171241.0TransmembraneHelical


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Fusion Gene Sequence for ERBB2-MED1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>27173_27173_1_ERBB2-MED1_ERBB2_chr17_37873733_ENST00000540042_MED1_chr17_37571592_ENST00000300651_length(transcript)=6309nt_BP=1986nt
GAATGCACAGGGTGGGCCTAGTCAGAAGAAGCCTTTCCCCTGAAATCCCTCTACTTCCCAAGCACGCAAGCTTTCTCCTGCTGTTAAACC
TGCAGTGTGCAAGGGACATGGGCGGAGGGGTCCTTCAGTCAGGCTTCTCCCTGTCTGAGTGTGCACCGGCACAGACATGAAGCTGCGGCT
CCCTGCCAGTCCCGAGACCCACCTGGACATGCTCCGCCACCTCTACCAGGGCTGCCAGGTGGTGCAGGGAAACCTGGAACTCACCTACCT
GCCCACCAATGCCAGCCTGTCCTTCCTGCAGGATATCCAGGAGGTGCAGGGCTACGTGCTCATCGCTCACAACCAAGTGAGGCAGGTCCC
ACTGCAGAGGCTGCGGATTGTGCGAGGCACCCAGCTCTTTGAGGACAACTATGCCCTGGCCGTGCTAGACAATGGAGACCCGCTGAACAA
TACCACCCCTGTCACAGGGGCCTCCCCAGGAGGCCTGCGGGAGCTGCAGCTTCGAAGCCTCACAGAGATCTTGAAAGGAGGGGTCTTGAT
CCAGCGGAACCCCCAGCTCTGCTACCAGGACACGATTTTGTGGAAGGACATCTTCCACAAGAACAACCAGCTGGCTCTCACACTGATAGA
CACCAACCGCTCTCGGGCCTGCCACCCCTGTTCTCCGATGTGTAAGGGCTCCCGCTGCTGGGGAGAGAGTTCTGAGGATTGTCAGAGCCT
GACGCGCACTGTCTGTGCCGGTGGCTGTGCCCGCTGCAAGGGGCCACTGCCCACTGACTGCTGCCATGAGCAGTGTGCTGCCGGCTGCAC
GGGCCCCAAGCACTCTGACTGCCTGGCCTGCCTCCACTTCAACCACAGTGGCATCTGTGAGCTGCACTGCCCAGCCCTGGTCACCTACAA
CACAGACACGTTTGAGTCCATGCCCAATCCCGAGGGCCGGTATACATTCGGCGCCAGCTGTGTGACTGCCTGTCCCTACAACTACCTTTC
TACGGACGTGGGATCCTGCACCCTCGTCTGCCCCCTGCACAACCAAGAGGTGACAGCAGAGGATGGAACACAGCGGTGTGAGAAGTGCAG
CAAGCCCTGTGCCCGAGTGTGCTATGGTCTGGGCATGGAGCACTTGCGAGAGGTGAGGGCAGTTACCAGTGCCAATATCCAGGAGTTTGC
TGGCTGCAAGAAGATCTTTGGGAGCCTGGCATTTCTGCCGGAGAGCTTTGATGGGGACCCAGCCTCCAACACTGCCCCGCTCCAGCCAGA
GCAGCTCCAAGTGTTTGAGACTCTGGAAGAGATCACAGGTTACCTATACATCTCAGCATGGCCGGACAGCCTGCCTGACCTCAGCGTCTT
CCAGAACCTGCAAGTAATCCGGGGACGAATTCTGCACAATGGCGCCTACTCGCTGACCCTGCAAGGGCTGGGCATCAGCTGGCTGGGGCT
GCGCTCACTGAGGGAACTGGGCAGTGGACTGGCCCTCATCCACCATAACACCCACCTCTGCTTCGTGCACACGGTGCCCTGGGACCAGCT
CTTTCGGAACCCGCACCAAGCTCTGCTCCACACTGCCAACCGGCCAGAGGACGAGTGTGTGGGCGAGGGCCTGGCCTGCCACCAGCTGTG
CGCCCGAGGGCACTGCTGGGGTCCAGGGCCCACCCAGTGTGTCAACTGCAGCCAGTTCCTTCGGGGCCAGGAGTGCGTGGAGGAATGCCG
AGTACTGCAGGGGCTCCCCAGGGAGTATGTGAATGCCAGGCACTGTTTGCCGTGCCACCCTGAGTGTCAGCCCCAGAATGGCTCAGTGAC
CTGTTTTGGACCGGTGAGTCCAACGGTCTTTTCTGCAGAAAGGAGGACTTTCCTTTCAGGGGTCTTTCTGGGGCTCTTACTATAAAAGGG
GACCAACTCTCCCTTTGTCATATCTTGTTTCTGATGACAAAAATAACACATTGTTAAAATTGTAAAATTAAAACATGAAATATAAATTAA
TGCCCTATTCTCCTGGGCTTCTCCAATTTGAAGTGTGTCCTCTCTCAGAGTCTCGTTTCAGCGTATCTTTTCAGCACCCTGTGAATGACT
CCCTGGTGTGTGTGGTAATGGATGTGCAGGACTCAACACATGTGAGCTGTAAACTCTACAAAGGGCTGTCGGATGCACTGATCTGCACAG
ATGACTTCATTGCCAAAGTTGTTCAAAGATGTATGTCCATCCCTGTGACGATGAGGGCTATTCGGAGGAAAGCTGAAACCATTCAAGCCG
ACACCCCAGCACTGTCCCTCATTGCAGAGACAGTTGAAGACATGGTGAAAAAGAACCTGCCCCCGGCTAGCAGCCCAGGGTATGGCATGA
CCACAGGCAACAACCCAATGAGTGGTACCACTACACCAACCAACACCTTTCCGGGGGGTCCCATTACCACCTTGTTTAATATGAGCATGA
GCATCAAAGATCGGCATGAGTCGGTGGGCCATGGGGAGGACTTCAGCAAGGTGTCTCAGAACCCAATTCTTACCAGTTTGTTGCAAATCA
CAGGGAACGGGGGGTCTACCATTGGCTCGAGTCCGACCCCTCCTCATCACACGCCGCCACCTGTCTCTTCGATGGCCGGCAACACCAAGA
ACCACCCGATGCTCATGAACCTTCTTAAAGATAATCCTGCCCAGGATTTCTCAACCCTTTATGGAAGCAGCCCTTTAGAAAGGCAGAACT
CCTCTTCCGGCTCACCCCGCATGGAAATATGCTCGGGGAGCAACAAGACCAAGAAAAAGAAGTCATCAAGATTACCACCTGAGAAACCAA
AGCACCAGACTGAAGATGACTTTCAGAGGGAGCTATTTTCAATGGATGTTGACTCACAGAACCCTATCTTTGATGTCAACATGACAGCTG
ACACGCTGGATACGCCACACATCACTCCAGCTCCAAGCCAGTGTAGCACTCCCCCAACAACTTACCCACAACCAGTACCTCACCCCCAAC
CCAGTATTCAAAGGATGGTCCGACTATCCAGTTCAGACAGCATTGGCCCAGATGTAACTGACATCCTTTCAGACATTGCAGAAGAAGCTT
CTAAACTTCCCAGCACTAGTGATGATTGCCCAGCCATTGGCACCCCTCTTCGAGATTCTTCAAGCTCTGGGCATTCTCAGAGTACCCTGT
TTGACTCTGATGTCTTTCAAACTAACAATAATGAAAATCCATACACTGATCCAGCTGATCTTATTGCAGATGCTGCTGGAAGCCCCAGTA
GTGACTCTCCTACCAATCATTTTTTTCATGATGGAGTAGATTTCAATCCTGATTTATTGAACAGCCAGAGCCAAAGTGGTTTTGGAGAAG
AATATTTTGATGAAAGCAGCCAAAGTGGGGATAATGATGATTTCAAAGGATTTGCATCTCAGGCACTAAATACTTTGGGGGTGCCAATGC
TTGGAGGTGATAATGGGGAGACCAAGTTTAAGGGCAATAACCAAGCCGACACAGTTGATTTCAGTATTATTTCAGTAGCCGGCAAAGCTT
TAGCTCCTGCAGATCTTATGGAGCATCACAGTGGTAGTCAGGGTCCTTTACTGACCACTGGGGACTTAGGGAAAGAAAAGACTCAAAAGA
GGGTAAAGGAAGGCAATGGCACCAGTAATAGTACTCTCTCGGGGCCCGGATTAGACAGCAAACCAGGGAAGCGCAGTCGGACCCCTTCTA
ATGATGGGAAAAGCAAAGATAAGCCTCCAAAGCGGAAGAAGGCAGACACTGAGGGAAAGTCTCCATCTCATAGTTCTTCTAACAGACCTT
TTACCCCACCTACCAGTACAGGTGGATCTAAATCGCCAGGCAGTGCAGGAAGATCTCAGACTCCCCCAGGTGTTGCCACACCACCCATTC
CCAAAATCACTATTCAGATTCCTAAGGGAACAGTGATGGTGGGCAAGCCTTCCTCTCACAGTCAGTATACCAGCAGTGGTTCTGTGTCTT
CCTCAGGCAGCAAAAGCCACCATAGCCATTCTTCCTCCTCTTCCTCATCTGCTTCCACCTCAGGGAAGATGAAAAGCAGTAAATCAGAAG
GTTCATCAAGTTCCAAGTTAAGTAGCAGTATGTATTCTAGCCAGGGGTCTTCTGGATCTAGCCAGTCCAAAAATTCATCCCAGTCTGGGG
GGAAGCCAGGCTCCTCTCCCATAACCAAGCATGGACTGAGCAGTGGCTCTAGCAGCACCAAGATGAAACCTCAAGGAAAGCCATCATCAC
TTATGAATCCTTCTTTAAGTAAACCAAACATATCCCCTTCTCATTCAAGGCCACCTGGAGGCTCTGACAAGCTTGCCTCTCCAATGAAGC
CTGTTCCTGGAACTCCTCCATCCTCTAAAGCCAAGTCCCCTATCAGTTCAGGTTCTGGTGGTTCTCATATGTCTGGAACTAGTTCAAGCT
CTGGCATGAAGTCATCTTCAGGGTTAGGATCCTCAGGCTCGTTGTCCCAGAAAACTCCCCCATCATCTAATTCCTGTACGGCATCTTCCT
CCTCCTTTTCCTCAAGTGGCTCTTCCATGTCATCCTCTCAGAACCAGCATGGGAGTTCTAAAGGAAAATCTCCCAGCAGAAACAAGAAGC
CGTCCTTGACAGCTGTCATAGATAAACTGAAGCATGGGGTTGTCACCAGTGGCCCTGGGGGTGAAGACCCACTGGACGGCCAGATGGGGG
TGAGCACAAATTCTTCCAGCCATCCTATGTCCTCCAAACATAACATGTCAGGAGGAGAGTTTCAGGGCAAGCGTGAGAAAAGTGATAAAG
ACAAATCAAAGGTTTCCACCTCCGGGAGTTCAGTGGATTCTTCTAAGAAGACCTCAGAGTCAAAAAATGTGGGGAGCACAGGTGTGGCAA
AAATTATCATCAGTAAGCATGATGGAGGCTCCCCTAGCATTAAAGCCAAAGTGACTTTGCAGAAACCTGGGGAAAGTAGTGGAGAAGGGC
TTAGGCCTCAAATGGCTTCTTCTAAAAACTATGGCTCTCCACTCATCAGTGGTTCCACTCCAAAGCATGAGCGTGGCTCTCCCAGCCATA
GTAAGTCACCAGCATATACCCCCCAGAATCTGGACAGTGAAAGTGAGTCAGGCTCCTCCATAGCAGAGAAATCTTATCAGAATAGTCCCA
GCTCAGACGATGGTATCCGACCACTTCCAGAATACAGCACAGAGAAACATAAGAAGCACAAAAAGGAAAAGAAGAAAGTAAAAGACAAAG
ATAGGGACCGAGACCGGGACAAAGACCGAGACAAGAAAAAATCTCATAGCATCAAGCCAGAGAGTTGGTCCAAATCACCCATCTCTTCAG
ACCAGTCCTTGTCTATGACAAGTAACACAATCTTATCTGCAGACAGACCCTCAAGGCTCAGCCCAGACTTTATGATTGGGGAGGAAGATG
ATGATCTTATGGATGTGGCCCTGATTGGGAATTAGGAACCTTATTTCCTAAAAGAAACAGGGCCAGAGGAAAAAAAACTATTGATAAGTT
TATAGGCAAACCACCATAAGGGGTGAGTCAGACAGGTCTGATTTGGTTAAGAATCCTAAATGGCATGGCTTTGACATCAAGCTGGGTGAA
TTAGAAAGGCATATCCAGACCCTATTAAAGAAACCACAGGGTTTGATTCTGGTTACCAGGAAGTCTTCTTTGTTCCTGTGCCAGAAAGAA
AGTTAAAATACTTGCTTAAGAAAGGGAGGGGGGTGGGAGGGGTGTAGGGAGAGGGAAGGGAGGGAAACAGTTTTGTGGGAAATATTCATA
TATATTTTCTTCTCCCTTTTTCCATTTTTAGGCCATGTTTTAAACTCATTTTAGTGCATGTATATGAAGGGCTGGGCAGAAAATGAAAAA
GCAATACATTCCTTGATGCATTTGCATGAAGGTTGTTCAACTTTGTTTGAGGTAGTTGTCCGTTTGAGTCATGGGCAAATGAAGGACTTT
GGTCATTTTGGACACTTAAGTAATGTTTGGTGTCTGTTTCTTAGGAGTGACTGGGGGAGGGAAGATTATTTTAGCTATTTATTTGTAATA
TTTTAACCCTTTATCTGTTTGTTTTTATACAGTGTTTCGTTCTAAATCTATGAGGTTTAGGGTTCAAAATGATGGAAGGCCGAAGAGCAA
GGCTTATATGGTGGTAGGGAGCTTATAGCTTGTGCTAATACTGTAGCATCAAGCCCAAGCAAATTAGTCAGAGCCCGCCTTTAGAGTTAA
ATATAATAGAAAAACCAAAATGATATTTTTATTTTAGGAGGGTTTAAATAGGGTTCAGAGATCATAGGAATATTAGGAGTTACCTCTCTG

>27173_27173_1_ERBB2-MED1_ERBB2_chr17_37873733_ENST00000540042_MED1_chr17_37571592_ENST00000300651_length(amino acids)=1156AA_BP=8
MKYKLMPYSPGLLQFEVCPLSESRFSVSFQHPVNDSLVCVVMDVQDSTHVSCKLYKGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKA
ETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTTGNNPMSGTTTPTNTFPGGPITTLFNMSMSIKDRHESVGHGEDFSKVSQNPILT
SLLQITGNGGSTIGSSPTPPHHTPPPVSSMAGNTKNHPMLMNLLKDNPAQDFSTLYGSSPLERQNSSSGSPRMEICSGSNKTKKKKSSRL
PPEKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPTTYPQPVPHPQPSIQRMVRLSSSDSIGPDVTDILSD
IAEEASKLPSTSDDCPAIGTPLRDSSSSGHSQSTLFDSDVFQTNNNENPYTDPADLIADAAGSPSSDSPTNHFFHDGVDFNPDLLNSQSQ
SGFGEEYFDESSQSGDNDDFKGFASQALNTLGVPMLGGDNGETKFKGNNQADTVDFSIISVAGKALAPADLMEHHSGSQGPLLTTGDLGK
EKTQKRVKEGNGTSNSTLSGPGLDSKPGKRSRTPSNDGKSKDKPPKRKKADTEGKSPSHSSSNRPFTPPTSTGGSKSPGSAGRSQTPPGV
ATPPIPKITIQIPKGTVMVGKPSSHSQYTSSGSVSSSGSKSHHSHSSSSSSSASTSGKMKSSKSEGSSSSKLSSSMYSSQGSSGSSQSKN
SSQSGGKPGSSPITKHGLSSGSSSTKMKPQGKPSSLMNPSLSKPNISPSHSRPPGGSDKLASPMKPVPGTPPSSKAKSPISSGSGGSHMS
GTSSSSGMKSSSGLGSSGSLSQKTPPSSNSCTASSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGGEDPL
DGQMGVSTNSSSHPMSSKHNMSGGEFQGKREKSDKDKSKVSTSGSSVDSSKKTSESKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGE
SSGEGLRPQMASSKNYGSPLISGSTPKHERGSPSHSKSPAYTPQNLDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSTEKHKKHKKEKK

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>27173_27173_2_ERBB2-MED1_ERBB2_chr17_37873733_ENST00000540042_MED1_chr17_37571592_ENST00000394287_length(transcript)=3353nt_BP=1986nt
GAATGCACAGGGTGGGCCTAGTCAGAAGAAGCCTTTCCCCTGAAATCCCTCTACTTCCCAAGCACGCAAGCTTTCTCCTGCTGTTAAACC
TGCAGTGTGCAAGGGACATGGGCGGAGGGGTCCTTCAGTCAGGCTTCTCCCTGTCTGAGTGTGCACCGGCACAGACATGAAGCTGCGGCT
CCCTGCCAGTCCCGAGACCCACCTGGACATGCTCCGCCACCTCTACCAGGGCTGCCAGGTGGTGCAGGGAAACCTGGAACTCACCTACCT
GCCCACCAATGCCAGCCTGTCCTTCCTGCAGGATATCCAGGAGGTGCAGGGCTACGTGCTCATCGCTCACAACCAAGTGAGGCAGGTCCC
ACTGCAGAGGCTGCGGATTGTGCGAGGCACCCAGCTCTTTGAGGACAACTATGCCCTGGCCGTGCTAGACAATGGAGACCCGCTGAACAA
TACCACCCCTGTCACAGGGGCCTCCCCAGGAGGCCTGCGGGAGCTGCAGCTTCGAAGCCTCACAGAGATCTTGAAAGGAGGGGTCTTGAT
CCAGCGGAACCCCCAGCTCTGCTACCAGGACACGATTTTGTGGAAGGACATCTTCCACAAGAACAACCAGCTGGCTCTCACACTGATAGA
CACCAACCGCTCTCGGGCCTGCCACCCCTGTTCTCCGATGTGTAAGGGCTCCCGCTGCTGGGGAGAGAGTTCTGAGGATTGTCAGAGCCT
GACGCGCACTGTCTGTGCCGGTGGCTGTGCCCGCTGCAAGGGGCCACTGCCCACTGACTGCTGCCATGAGCAGTGTGCTGCCGGCTGCAC
GGGCCCCAAGCACTCTGACTGCCTGGCCTGCCTCCACTTCAACCACAGTGGCATCTGTGAGCTGCACTGCCCAGCCCTGGTCACCTACAA
CACAGACACGTTTGAGTCCATGCCCAATCCCGAGGGCCGGTATACATTCGGCGCCAGCTGTGTGACTGCCTGTCCCTACAACTACCTTTC
TACGGACGTGGGATCCTGCACCCTCGTCTGCCCCCTGCACAACCAAGAGGTGACAGCAGAGGATGGAACACAGCGGTGTGAGAAGTGCAG
CAAGCCCTGTGCCCGAGTGTGCTATGGTCTGGGCATGGAGCACTTGCGAGAGGTGAGGGCAGTTACCAGTGCCAATATCCAGGAGTTTGC
TGGCTGCAAGAAGATCTTTGGGAGCCTGGCATTTCTGCCGGAGAGCTTTGATGGGGACCCAGCCTCCAACACTGCCCCGCTCCAGCCAGA
GCAGCTCCAAGTGTTTGAGACTCTGGAAGAGATCACAGGTTACCTATACATCTCAGCATGGCCGGACAGCCTGCCTGACCTCAGCGTCTT
CCAGAACCTGCAAGTAATCCGGGGACGAATTCTGCACAATGGCGCCTACTCGCTGACCCTGCAAGGGCTGGGCATCAGCTGGCTGGGGCT
GCGCTCACTGAGGGAACTGGGCAGTGGACTGGCCCTCATCCACCATAACACCCACCTCTGCTTCGTGCACACGGTGCCCTGGGACCAGCT
CTTTCGGAACCCGCACCAAGCTCTGCTCCACACTGCCAACCGGCCAGAGGACGAGTGTGTGGGCGAGGGCCTGGCCTGCCACCAGCTGTG
CGCCCGAGGGCACTGCTGGGGTCCAGGGCCCACCCAGTGTGTCAACTGCAGCCAGTTCCTTCGGGGCCAGGAGTGCGTGGAGGAATGCCG
AGTACTGCAGGGGCTCCCCAGGGAGTATGTGAATGCCAGGCACTGTTTGCCGTGCCACCCTGAGTGTCAGCCCCAGAATGGCTCAGTGAC
CTGTTTTGGACCGGTGAGTCCAACGGTCTTTTCTGCAGAAAGGAGGACTTTCCTTTCAGGGGTCTTTCTGGGGCTCTTACTATAAAAGGG
GACCAACTCTCCCTTTGTCATATCTTGTTTCTGATGACAAAAATAACACATTGTTAAAATTGTAAAATTAAAACATGAAATATAAATTAA
TGCCCTATTCTCCTGGGCTTCTCCAATTTGAAGTGTGTCCTCTCTCAGAGTCTCGTTTCAGCGTATCTTTTCAGCACCCTGTGAATGACT
CCCTGGTGTGTGTGGTAATGGATGTGCAGGACTCAACACATGTGAGCTGTAAACTCTACAAAGGGCTGTCGGATGCACTGATCTGCACAG
ATGACTTCATTGCCAAAGTTGTTCAAAGATGTATGTCCATCCCTGTGACGATGAGGGCTATTCGGAGGAAAGCTGAAACCATTCAAGCCG
ACACCCCAGCACTGTCCCTCATTGCAGAGACAGTTGAAGACATGGTGAAAAAGAACCTGCCCCCGGCTAGCAGCCCAGGATCAAAGAATC
CCGAGTTAGGATCTGGATGAAGGATAAGCCCCTGAATTGTCGATGGGCTCACCCCCACACTGACCCAGCATCTGAACTTGCTTAACAGGG
AGCCGGGGCTAAACTGCTTCACCCTGCCTGAGAACCAGGGAGCACTGCATTTCTCCACAGGGTGGAGGAGAAGAGGCAGAATAAACCAAG
CCTGGGACACCTCCCTCCTGTCTAGGTGTACTCATTCTTCTGTTTCAAAAGAAGGCAAGGACATGAAGTCAACTTCTACCTATCTTCTGC
TGCTGGTGTCTTATGTATTCTCAGTTTGACCTGATTCCTCTTCTGTCTTTTGACTTAACATTAGGGGTTCTTGGTCATAACCTGCTCTGA
TGTACATAAAGATTTCAGGTTCAATATCAATGTGTCTTAAAACAGAAGTATTTTAGCGGGTGGGGGGTGGGGTGGTGGGGACAAACAACG
CAGGATATAATTGCCAAAACCAGGCTTGAGGTTGGTGACTCTTGAAAGATTTTCTTTCTTCAGGCCTAGATCAGAAAATTAAGTGCAGCA
ATATCATGAATTCTCAGAAGCCCTTTCAGGGAGCCAGTGAGTCATACAGTATCCACAGTTGAGTCACTTAAAGATGTCAGTATACGAAAC
ATTATTCACAATCCTTGGGCAATCTCATTTTTTTTTCCTTCTCCCCTCCTCCCCTGCCCCCCATACATTTCTATCCTTGAGTTAGTTTTG
GAGGGGCAGGAAGTACTTAACATCTCAGAAGCTAGATTGGGAAACATGCTCAGCTATAAGAACTGAGCTTTAAATTTTGAGTTTAAAAAT
GTACATCAGGAGCAGCTGGGGAGGGTCTTTTTTTAAAAAAATCTTTCAAATTTGGTTTTCTGTGCATATGGCCGTTTTGTAAATACTTTG
GGGTTTTTCATTTTTTTGAAAGTAGATGAAATCTGTTGTGGGATTTTTTTCCCGAAACATTACAAAATAACCTGTTTATTTACATGCAAA

>27173_27173_2_ERBB2-MED1_ERBB2_chr17_37873733_ENST00000540042_MED1_chr17_37571592_ENST00000394287_length(amino acids)=572AA_BP=
MKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNG
DPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSE
DCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP
YNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTA
PLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTV
PWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARHCLPCHPECQPQ

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Fusion Gene PPI Analysis for ERBB2-MED1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneMED1chr17:37873733chr17:37571592ENST000003006511317656_1066432.33333333333331582.0ESR1
TgeneMED1chr17:37873733chr17:37571592ENST000003942871318656_1066432.3333333333333557.0ESR1
TgeneMED1chr17:37873733chr17:37571592ENST000003006511317681_715432.33333333333331582.0GATA1
TgeneMED1chr17:37873733chr17:37571592ENST000003942871318681_715432.3333333333333557.0GATA1
TgeneMED1chr17:37873733chr17:37571592ENST000003006511317622_701432.33333333333331582.0PPARGC1A and THRA
TgeneMED1chr17:37873733chr17:37571592ENST000003942871318622_701432.3333333333333557.0PPARGC1A and THRA
TgeneMED1chr17:37873733chr17:37571592ENST0000030065113171249_1421432.33333333333331582.0TP53
TgeneMED1chr17:37873733chr17:37571592ENST0000039428713181249_1421432.3333333333333557.0TP53
TgeneMED1chr17:37873733chr17:37571592ENST000003006511317542_789432.33333333333331582.0VDR
TgeneMED1chr17:37873733chr17:37571592ENST000003942871318542_789432.3333333333333557.0VDR


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneERBB2chr17:37873733chr17:37571592ENST00000269571+15271195_1197632.66666666666661256.0PIK3C2B
HgeneERBB2chr17:37873733chr17:37571592ENST00000541774+15271195_1197617.66666666666661241.0PIK3C2B
TgeneMED1chr17:37873733chr17:37571592ENST00000300651131716_590432.33333333333331582.0ESR1
TgeneMED1chr17:37873733chr17:37571592ENST00000394287131816_590432.3333333333333557.0ESR1
TgeneMED1chr17:37873733chr17:37571592ENST000003006511317108_212432.33333333333331582.0the Mediator complex
TgeneMED1chr17:37873733chr17:37571592ENST000003006511317215_390432.33333333333331582.0the Mediator complex
TgeneMED1chr17:37873733chr17:37571592ENST000003942871318108_212432.3333333333333557.0the Mediator complex
TgeneMED1chr17:37873733chr17:37571592ENST000003942871318215_390432.3333333333333557.0the Mediator complex
TgeneMED1chr17:37873733chr17:37571592ENST0000030065113171_670432.33333333333331582.0the Mediator complex and THRA
TgeneMED1chr17:37873733chr17:37571592ENST0000039428713181_670432.3333333333333557.0the Mediator complex and THRA
TgeneMED1chr17:37873733chr17:37571592ENST000003006511317405_644432.33333333333331582.0THRA
TgeneMED1chr17:37873733chr17:37571592ENST000003942871318405_644432.3333333333333557.0THRA


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ERBB2-MED1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ERBB2-MED1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource