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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ERBB2-STARD3 (FusionGDB2 ID:27195)

Fusion Gene Summary for ERBB2-STARD3

check button Fusion gene summary
Fusion gene informationFusion gene name: ERBB2-STARD3
Fusion gene ID: 27195
HgeneTgene
Gene symbol

ERBB2

STARD3

Gene ID

2064

10948

Gene nameerb-b2 receptor tyrosine kinase 2StAR related lipid transfer domain containing 3
SynonymsCD340|HER-2|HER-2/neu|HER2|MLN 19|NEU|NGL|TKR1CAB1|MLN64|es64
Cytomap

17q12

17q12

Type of geneprotein-codingprotein-coding
Descriptionreceptor tyrosine-protein kinase erbB-2c-erb B2/neu proteinherstatinhuman epidermal growth factor receptor 2metastatic lymph node gene 19 proteinneuro/glioblastoma derived oncogene homologneuroblastoma/glioblastoma derived oncogene homologp185erbB2stAR-related lipid transfer protein 3MLN 64START domain-containing protein 3StAR-related lipid transfer (START) domain containing 3metastatic lymph node gene 64 proteinmetastatic lymph node protein 64steroidogenic acute regulatory protein related
Modification date2020032920200313
UniProtAcc

P04626

STARD3NL

Ensembl transtripts involved in fusion geneENST00000269571, ENST00000406381, 
ENST00000540042, ENST00000540147, 
ENST00000541774, ENST00000578199, 
ENST00000584450, ENST00000584601, 
ENST00000445658, ENST00000584888, 
ENST00000394250, ENST00000544210, 
ENST00000578232, ENST00000580611, 
ENST00000336308, 
Fusion gene scores* DoF score50 X 44 X 14=3080015 X 10 X 10=1500
# samples 7324
** MAII scorelog2(73/30800*10)=-5.39889007670225
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(24/1500*10)=-2.64385618977472
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ERBB2 [Title/Abstract] AND STARD3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointERBB2(37872858)-STARD3(37816463), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneERBB2

GO:0007165

signal transduction

10572067

HgeneERBB2

GO:0007166

cell surface receptor signaling pathway

9685399

HgeneERBB2

GO:0007169

transmembrane receptor protein tyrosine kinase signaling pathway

7514177

HgeneERBB2

GO:0014065

phosphatidylinositol 3-kinase signaling

7556068

HgeneERBB2

GO:0018108

peptidyl-tyrosine phosphorylation

12000754

HgeneERBB2

GO:0032886

regulation of microtubule-based process

20937854

HgeneERBB2

GO:0035556

intracellular signal transduction

19372587

HgeneERBB2

GO:0042060

wound healing

12646923

HgeneERBB2

GO:0043406

positive regulation of MAP kinase activity

10572067

HgeneERBB2

GO:0045785

positive regulation of cell adhesion

7556068

HgeneERBB2

GO:0046777

protein autophosphorylation

7556068

HgeneERBB2

GO:0050679

positive regulation of epithelial cell proliferation

10572067

HgeneERBB2

GO:0071363

cellular response to growth factor stimulus

20010870

HgeneERBB2

GO:0090314

positive regulation of protein targeting to membrane

20010870

TgeneSTARD3

GO:0030301

cholesterol transport

28377464

TgeneSTARD3

GO:0099044

vesicle tethering to endoplasmic reticulum

24105263|28377464


check buttonFusion gene breakpoints across ERBB2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across STARD3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4CESCTCGA-Q1-A73R-01AERBB2chr17

37866733

+STARD3chr17

37815303

+
ChimerDB4CESCTCGA-Q1-A73R-01AERBB2chr17

37872857

+STARD3chr17

37809733

+
ChimerDB4CESCTCGA-Q1-A73R-01AERBB2chr17

37873732

+STARD3chr17

37809733

+
ChimerDB4CESCTCGA-Q1-A73RERBB2chr17

37866734

+STARD3chr17

37815303

+
ChimerDB4ESCATCGA-M9-A5M8ERBB2chr17

37872858

+STARD3chr17

37816463

+
ChimerDB4STADTCGA-CD-5799-01AERBB2chr17

37856564

+STARD3chr17

37809734

+


Top

Fusion Gene ORF analysis for ERBB2-STARD3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000269571ENST00000394250ERBB2chr17

37866733

+STARD3chr17

37815303

+
5CDS-3UTRENST00000269571ENST00000394250ERBB2chr17

37866734

+STARD3chr17

37815303

+
5CDS-3UTRENST00000269571ENST00000544210ERBB2chr17

37866733

+STARD3chr17

37815303

+
5CDS-3UTRENST00000269571ENST00000544210ERBB2chr17

37866734

+STARD3chr17

37815303

+
5CDS-3UTRENST00000269571ENST00000578232ERBB2chr17

37866733

+STARD3chr17

37815303

+
5CDS-3UTRENST00000269571ENST00000578232ERBB2chr17

37866734

+STARD3chr17

37815303

+
5CDS-3UTRENST00000269571ENST00000580611ERBB2chr17

37866733

+STARD3chr17

37815303

+
5CDS-3UTRENST00000269571ENST00000580611ERBB2chr17

37866734

+STARD3chr17

37815303

+
5CDS-3UTRENST00000406381ENST00000394250ERBB2chr17

37866733

+STARD3chr17

37815303

+
5CDS-3UTRENST00000406381ENST00000394250ERBB2chr17

37866734

+STARD3chr17

37815303

+
5CDS-3UTRENST00000406381ENST00000544210ERBB2chr17

37866733

+STARD3chr17

37815303

+
5CDS-3UTRENST00000406381ENST00000544210ERBB2chr17

37866734

+STARD3chr17

37815303

+
5CDS-3UTRENST00000406381ENST00000578232ERBB2chr17

37866733

+STARD3chr17

37815303

+
5CDS-3UTRENST00000406381ENST00000578232ERBB2chr17

37866734

+STARD3chr17

37815303

+
5CDS-3UTRENST00000406381ENST00000580611ERBB2chr17

37866733

+STARD3chr17

37815303

+
5CDS-3UTRENST00000406381ENST00000580611ERBB2chr17

37866734

+STARD3chr17

37815303

+
5CDS-3UTRENST00000540042ENST00000394250ERBB2chr17

37866733

+STARD3chr17

37815303

+
5CDS-3UTRENST00000540042ENST00000394250ERBB2chr17

37866734

+STARD3chr17

37815303

+
5CDS-3UTRENST00000540042ENST00000544210ERBB2chr17

37866733

+STARD3chr17

37815303

+
5CDS-3UTRENST00000540042ENST00000544210ERBB2chr17

37866734

+STARD3chr17

37815303

+
5CDS-3UTRENST00000540042ENST00000578232ERBB2chr17

37866733

+STARD3chr17

37815303

+
5CDS-3UTRENST00000540042ENST00000578232ERBB2chr17

37866734

+STARD3chr17

37815303

+
5CDS-3UTRENST00000540042ENST00000580611ERBB2chr17

37866733

+STARD3chr17

37815303

+
5CDS-3UTRENST00000540042ENST00000580611ERBB2chr17

37866734

+STARD3chr17

37815303

+
5CDS-3UTRENST00000540147ENST00000394250ERBB2chr17

37866733

+STARD3chr17

37815303

+
5CDS-3UTRENST00000540147ENST00000394250ERBB2chr17

37866734

+STARD3chr17

37815303

+
5CDS-3UTRENST00000540147ENST00000544210ERBB2chr17

37866733

+STARD3chr17

37815303

+
5CDS-3UTRENST00000540147ENST00000544210ERBB2chr17

37866734

+STARD3chr17

37815303

+
5CDS-3UTRENST00000540147ENST00000578232ERBB2chr17

37866733

+STARD3chr17

37815303

+
5CDS-3UTRENST00000540147ENST00000578232ERBB2chr17

37866734

+STARD3chr17

37815303

+
5CDS-3UTRENST00000540147ENST00000580611ERBB2chr17

37866733

+STARD3chr17

37815303

+
5CDS-3UTRENST00000540147ENST00000580611ERBB2chr17

37866734

+STARD3chr17

37815303

+
5CDS-3UTRENST00000541774ENST00000394250ERBB2chr17

37866733

+STARD3chr17

37815303

+
5CDS-3UTRENST00000541774ENST00000394250ERBB2chr17

37866734

+STARD3chr17

37815303

+
5CDS-3UTRENST00000541774ENST00000544210ERBB2chr17

37866733

+STARD3chr17

37815303

+
5CDS-3UTRENST00000541774ENST00000544210ERBB2chr17

37866734

+STARD3chr17

37815303

+
5CDS-3UTRENST00000541774ENST00000578232ERBB2chr17

37866733

+STARD3chr17

37815303

+
5CDS-3UTRENST00000541774ENST00000578232ERBB2chr17

37866734

+STARD3chr17

37815303

+
5CDS-3UTRENST00000541774ENST00000580611ERBB2chr17

37866733

+STARD3chr17

37815303

+
5CDS-3UTRENST00000541774ENST00000580611ERBB2chr17

37866734

+STARD3chr17

37815303

+
5CDS-3UTRENST00000578199ENST00000394250ERBB2chr17

37866733

+STARD3chr17

37815303

+
5CDS-3UTRENST00000578199ENST00000394250ERBB2chr17

37866734

+STARD3chr17

37815303

+
5CDS-3UTRENST00000578199ENST00000544210ERBB2chr17

37866733

+STARD3chr17

37815303

+
5CDS-3UTRENST00000578199ENST00000544210ERBB2chr17

37866734

+STARD3chr17

37815303

+
5CDS-3UTRENST00000578199ENST00000578232ERBB2chr17

37866733

+STARD3chr17

37815303

+
5CDS-3UTRENST00000578199ENST00000578232ERBB2chr17

37866734

+STARD3chr17

37815303

+
5CDS-3UTRENST00000578199ENST00000580611ERBB2chr17

37866733

+STARD3chr17

37815303

+
5CDS-3UTRENST00000578199ENST00000580611ERBB2chr17

37866734

+STARD3chr17

37815303

+
5CDS-3UTRENST00000584450ENST00000394250ERBB2chr17

37866733

+STARD3chr17

37815303

+
5CDS-3UTRENST00000584450ENST00000394250ERBB2chr17

37866734

+STARD3chr17

37815303

+
5CDS-3UTRENST00000584450ENST00000544210ERBB2chr17

37866733

+STARD3chr17

37815303

+
5CDS-3UTRENST00000584450ENST00000544210ERBB2chr17

37866734

+STARD3chr17

37815303

+
5CDS-3UTRENST00000584450ENST00000578232ERBB2chr17

37866733

+STARD3chr17

37815303

+
5CDS-3UTRENST00000584450ENST00000578232ERBB2chr17

37866734

+STARD3chr17

37815303

+
5CDS-3UTRENST00000584450ENST00000580611ERBB2chr17

37866733

+STARD3chr17

37815303

+
5CDS-3UTRENST00000584450ENST00000580611ERBB2chr17

37866734

+STARD3chr17

37815303

+
5CDS-3UTRENST00000584601ENST00000394250ERBB2chr17

37866733

+STARD3chr17

37815303

+
5CDS-3UTRENST00000584601ENST00000394250ERBB2chr17

37866734

+STARD3chr17

37815303

+
5CDS-3UTRENST00000584601ENST00000544210ERBB2chr17

37866733

+STARD3chr17

37815303

+
5CDS-3UTRENST00000584601ENST00000544210ERBB2chr17

37866734

+STARD3chr17

37815303

+
5CDS-3UTRENST00000584601ENST00000578232ERBB2chr17

37866733

+STARD3chr17

37815303

+
5CDS-3UTRENST00000584601ENST00000578232ERBB2chr17

37866734

+STARD3chr17

37815303

+
5CDS-3UTRENST00000584601ENST00000580611ERBB2chr17

37866733

+STARD3chr17

37815303

+
5CDS-3UTRENST00000584601ENST00000580611ERBB2chr17

37866734

+STARD3chr17

37815303

+
5CDS-5UTRENST00000269571ENST00000336308ERBB2chr17

37872857

+STARD3chr17

37809733

+
5CDS-5UTRENST00000269571ENST00000336308ERBB2chr17

37873732

+STARD3chr17

37809733

+
5CDS-5UTRENST00000269571ENST00000336308ERBB2chr17

37856564

+STARD3chr17

37809734

+
5CDS-5UTRENST00000269571ENST00000394250ERBB2chr17

37872857

+STARD3chr17

37809733

+
5CDS-5UTRENST00000269571ENST00000394250ERBB2chr17

37873732

+STARD3chr17

37809733

+
5CDS-5UTRENST00000269571ENST00000394250ERBB2chr17

37856564

+STARD3chr17

37809734

+
5CDS-5UTRENST00000269571ENST00000544210ERBB2chr17

37872857

+STARD3chr17

37809733

+
5CDS-5UTRENST00000269571ENST00000544210ERBB2chr17

37873732

+STARD3chr17

37809733

+
5CDS-5UTRENST00000269571ENST00000544210ERBB2chr17

37856564

+STARD3chr17

37809734

+
5CDS-5UTRENST00000269571ENST00000580611ERBB2chr17

37872857

+STARD3chr17

37809733

+
5CDS-5UTRENST00000269571ENST00000580611ERBB2chr17

37873732

+STARD3chr17

37809733

+
5CDS-5UTRENST00000269571ENST00000580611ERBB2chr17

37856564

+STARD3chr17

37809734

+
5CDS-5UTRENST00000406381ENST00000336308ERBB2chr17

37872857

+STARD3chr17

37809733

+
5CDS-5UTRENST00000406381ENST00000336308ERBB2chr17

37873732

+STARD3chr17

37809733

+
5CDS-5UTRENST00000406381ENST00000394250ERBB2chr17

37872857

+STARD3chr17

37809733

+
5CDS-5UTRENST00000406381ENST00000394250ERBB2chr17

37873732

+STARD3chr17

37809733

+
5CDS-5UTRENST00000406381ENST00000544210ERBB2chr17

37872857

+STARD3chr17

37809733

+
5CDS-5UTRENST00000406381ENST00000544210ERBB2chr17

37873732

+STARD3chr17

37809733

+
5CDS-5UTRENST00000406381ENST00000580611ERBB2chr17

37872857

+STARD3chr17

37809733

+
5CDS-5UTRENST00000406381ENST00000580611ERBB2chr17

37873732

+STARD3chr17

37809733

+
5CDS-5UTRENST00000445658ENST00000336308ERBB2chr17

37872857

+STARD3chr17

37809733

+
5CDS-5UTRENST00000445658ENST00000336308ERBB2chr17

37873732

+STARD3chr17

37809733

+
5CDS-5UTRENST00000445658ENST00000336308ERBB2chr17

37856564

+STARD3chr17

37809734

+
5CDS-5UTRENST00000445658ENST00000394250ERBB2chr17

37872857

+STARD3chr17

37809733

+
5CDS-5UTRENST00000445658ENST00000394250ERBB2chr17

37873732

+STARD3chr17

37809733

+
5CDS-5UTRENST00000445658ENST00000394250ERBB2chr17

37856564

+STARD3chr17

37809734

+
5CDS-5UTRENST00000445658ENST00000544210ERBB2chr17

37872857

+STARD3chr17

37809733

+
5CDS-5UTRENST00000445658ENST00000544210ERBB2chr17

37873732

+STARD3chr17

37809733

+
5CDS-5UTRENST00000445658ENST00000544210ERBB2chr17

37856564

+STARD3chr17

37809734

+
5CDS-5UTRENST00000445658ENST00000580611ERBB2chr17

37872857

+STARD3chr17

37809733

+
5CDS-5UTRENST00000445658ENST00000580611ERBB2chr17

37873732

+STARD3chr17

37809733

+
5CDS-5UTRENST00000445658ENST00000580611ERBB2chr17

37856564

+STARD3chr17

37809734

+
5CDS-5UTRENST00000540042ENST00000336308ERBB2chr17

37872857

+STARD3chr17

37809733

+
5CDS-5UTRENST00000540042ENST00000336308ERBB2chr17

37873732

+STARD3chr17

37809733

+
5CDS-5UTRENST00000540042ENST00000394250ERBB2chr17

37872857

+STARD3chr17

37809733

+
5CDS-5UTRENST00000540042ENST00000394250ERBB2chr17

37873732

+STARD3chr17

37809733

+
5CDS-5UTRENST00000540042ENST00000544210ERBB2chr17

37872857

+STARD3chr17

37809733

+
5CDS-5UTRENST00000540042ENST00000544210ERBB2chr17

37873732

+STARD3chr17

37809733

+
5CDS-5UTRENST00000540042ENST00000580611ERBB2chr17

37872857

+STARD3chr17

37809733

+
5CDS-5UTRENST00000540042ENST00000580611ERBB2chr17

37873732

+STARD3chr17

37809733

+
5CDS-5UTRENST00000540147ENST00000336308ERBB2chr17

37872857

+STARD3chr17

37809733

+
5CDS-5UTRENST00000540147ENST00000336308ERBB2chr17

37873732

+STARD3chr17

37809733

+
5CDS-5UTRENST00000540147ENST00000394250ERBB2chr17

37872857

+STARD3chr17

37809733

+
5CDS-5UTRENST00000540147ENST00000394250ERBB2chr17

37873732

+STARD3chr17

37809733

+
5CDS-5UTRENST00000540147ENST00000544210ERBB2chr17

37872857

+STARD3chr17

37809733

+
5CDS-5UTRENST00000540147ENST00000544210ERBB2chr17

37873732

+STARD3chr17

37809733

+
5CDS-5UTRENST00000540147ENST00000580611ERBB2chr17

37872857

+STARD3chr17

37809733

+
5CDS-5UTRENST00000540147ENST00000580611ERBB2chr17

37873732

+STARD3chr17

37809733

+
5CDS-5UTRENST00000541774ENST00000336308ERBB2chr17

37872857

+STARD3chr17

37809733

+
5CDS-5UTRENST00000541774ENST00000336308ERBB2chr17

37873732

+STARD3chr17

37809733

+
5CDS-5UTRENST00000541774ENST00000394250ERBB2chr17

37872857

+STARD3chr17

37809733

+
5CDS-5UTRENST00000541774ENST00000394250ERBB2chr17

37873732

+STARD3chr17

37809733

+
5CDS-5UTRENST00000541774ENST00000544210ERBB2chr17

37872857

+STARD3chr17

37809733

+
5CDS-5UTRENST00000541774ENST00000544210ERBB2chr17

37873732

+STARD3chr17

37809733

+
5CDS-5UTRENST00000541774ENST00000580611ERBB2chr17

37872857

+STARD3chr17

37809733

+
5CDS-5UTRENST00000541774ENST00000580611ERBB2chr17

37873732

+STARD3chr17

37809733

+
5CDS-5UTRENST00000578199ENST00000336308ERBB2chr17

37872857

+STARD3chr17

37809733

+
5CDS-5UTRENST00000578199ENST00000336308ERBB2chr17

37873732

+STARD3chr17

37809733

+
5CDS-5UTRENST00000578199ENST00000394250ERBB2chr17

37872857

+STARD3chr17

37809733

+
5CDS-5UTRENST00000578199ENST00000394250ERBB2chr17

37873732

+STARD3chr17

37809733

+
5CDS-5UTRENST00000578199ENST00000544210ERBB2chr17

37872857

+STARD3chr17

37809733

+
5CDS-5UTRENST00000578199ENST00000544210ERBB2chr17

37873732

+STARD3chr17

37809733

+
5CDS-5UTRENST00000578199ENST00000580611ERBB2chr17

37872857

+STARD3chr17

37809733

+
5CDS-5UTRENST00000578199ENST00000580611ERBB2chr17

37873732

+STARD3chr17

37809733

+
5CDS-5UTRENST00000584450ENST00000336308ERBB2chr17

37872857

+STARD3chr17

37809733

+
5CDS-5UTRENST00000584450ENST00000336308ERBB2chr17

37873732

+STARD3chr17

37809733

+
5CDS-5UTRENST00000584450ENST00000336308ERBB2chr17

37856564

+STARD3chr17

37809734

+
5CDS-5UTRENST00000584450ENST00000394250ERBB2chr17

37872857

+STARD3chr17

37809733

+
5CDS-5UTRENST00000584450ENST00000394250ERBB2chr17

37873732

+STARD3chr17

37809733

+
5CDS-5UTRENST00000584450ENST00000394250ERBB2chr17

37856564

+STARD3chr17

37809734

+
5CDS-5UTRENST00000584450ENST00000544210ERBB2chr17

37872857

+STARD3chr17

37809733

+
5CDS-5UTRENST00000584450ENST00000544210ERBB2chr17

37873732

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37809733

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intron-5UTRENST00000584888ENST00000544210ERBB2chr17

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intron-5UTRENST00000584888ENST00000580611ERBB2chr17

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intron-5UTRENST00000584888ENST00000580611ERBB2chr17

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intron-5UTRENST00000584888ENST00000580611ERBB2chr17

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intron-intronENST00000406381ENST00000578232ERBB2chr17

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intron-intronENST00000540042ENST00000578232ERBB2chr17

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intron-intronENST00000541774ENST00000578232ERBB2chr17

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intron-intronENST00000578199ENST00000578232ERBB2chr17

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intron-intronENST00000584601ENST00000578232ERBB2chr17

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intron-intronENST00000584888ENST00000394250ERBB2chr17

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intron-intronENST00000584888ENST00000544210ERBB2chr17

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intron-intronENST00000584888ENST00000578232ERBB2chr17

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intron-intronENST00000584888ENST00000578232ERBB2chr17

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intron-intronENST00000584888ENST00000578232ERBB2chr17

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intron-intronENST00000584888ENST00000578232ERBB2chr17

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intron-intronENST00000584888ENST00000580611ERBB2chr17

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check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for ERBB2-STARD3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ERBB2chr1737866734+STARD3chr1737815303+0.0454476850.95455235
ERBB2chr1737866734+STARD3chr1737815303+0.0454476850.95455235
ERBB2chr1737856564+STARD3chr1737809733+4.18E-060.9999958
ERBB2chr1737872858+STARD3chr1737809733+8.36E-070.99999917
ERBB2chr1737872858+STARD3chr1737816463+1.13E-081
ERBB2chr1737873733+STARD3chr1737809733+1.85E-081
ERBB2chr1737866734+STARD3chr1737815303+0.0454476850.95455235
ERBB2chr1737866734+STARD3chr1737815303+0.0454476850.95455235
ERBB2chr1737856564+STARD3chr1737809733+4.18E-060.9999958
ERBB2chr1737872858+STARD3chr1737809733+8.36E-070.99999917
ERBB2chr1737872858+STARD3chr1737816463+1.13E-081
ERBB2chr1737873733+STARD3chr1737809733+1.85E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ERBB2-STARD3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:37872858/chr17:37816463)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ERBB2

P04626

STARD3

STARD3NL

FUNCTION: Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. {ECO:0000305}.; FUNCTION: In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth. {ECO:0000269|PubMed:10358079, ECO:0000269|PubMed:15380516, ECO:0000269|PubMed:21555369}.234

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSTARD3chr17:37866733chr17:37815303ENST00000336308615230_443215446.0DomainSTART
TgeneSTARD3chr17:37866733chr17:37815303ENST00000394250514230_443197428.0DomainSTART
TgeneSTARD3chr17:37866733chr17:37815303ENST00000544210615230_443215446.0DomainSTART
TgeneSTARD3chr17:37866734chr17:37815303ENST00000336308615230_443215446.0DomainSTART
TgeneSTARD3chr17:37866734chr17:37815303ENST00000394250514230_443197428.0DomainSTART
TgeneSTARD3chr17:37866734chr17:37815303ENST00000544210615230_443215446.0DomainSTART
TgeneSTARD3chr17:37866733chr17:37815303ENST00000394250514207_212197428.0MotifFFAT
TgeneSTARD3chr17:37866734chr17:37815303ENST00000394250514207_212197428.0MotifFFAT

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneERBB2chr17:37866733chr17:37815303ENST00000269571+727720_9873001256.0DomainProtein kinase
HgeneERBB2chr17:37866733chr17:37815303ENST00000541774+727720_9872851241.0DomainProtein kinase
HgeneERBB2chr17:37866734chr17:37815303ENST00000269571+727720_9873001256.0DomainProtein kinase
HgeneERBB2chr17:37866734chr17:37815303ENST00000541774+727720_9872851241.0DomainProtein kinase
HgeneERBB2chr17:37872858chr17:37816463ENST00000269571+1427720_9875791256.0DomainProtein kinase
HgeneERBB2chr17:37872858chr17:37816463ENST00000541774+1427720_9875641241.0DomainProtein kinase
HgeneERBB2chr17:37866733chr17:37815303ENST00000269571+727676_6893001256.0MotifNote=Nuclear localization signal
HgeneERBB2chr17:37866733chr17:37815303ENST00000541774+727676_6892851241.0MotifNote=Nuclear localization signal
HgeneERBB2chr17:37866734chr17:37815303ENST00000269571+727676_6893001256.0MotifNote=Nuclear localization signal
HgeneERBB2chr17:37866734chr17:37815303ENST00000541774+727676_6892851241.0MotifNote=Nuclear localization signal
HgeneERBB2chr17:37872858chr17:37816463ENST00000269571+1427676_6895791256.0MotifNote=Nuclear localization signal
HgeneERBB2chr17:37872858chr17:37816463ENST00000541774+1427676_6895641241.0MotifNote=Nuclear localization signal
HgeneERBB2chr17:37866733chr17:37815303ENST00000269571+727726_7343001256.0Nucleotide bindingATP
HgeneERBB2chr17:37866733chr17:37815303ENST00000541774+727726_7342851241.0Nucleotide bindingATP
HgeneERBB2chr17:37866734chr17:37815303ENST00000269571+727726_7343001256.0Nucleotide bindingATP
HgeneERBB2chr17:37866734chr17:37815303ENST00000541774+727726_7342851241.0Nucleotide bindingATP
HgeneERBB2chr17:37872858chr17:37816463ENST00000269571+1427726_7345791256.0Nucleotide bindingATP
HgeneERBB2chr17:37872858chr17:37816463ENST00000541774+1427726_7345641241.0Nucleotide bindingATP
HgeneERBB2chr17:37866733chr17:37815303ENST00000269571+72723_6523001256.0Topological domainExtracellular
HgeneERBB2chr17:37866733chr17:37815303ENST00000269571+727676_12553001256.0Topological domainCytoplasmic
HgeneERBB2chr17:37866733chr17:37815303ENST00000541774+72723_6522851241.0Topological domainExtracellular
HgeneERBB2chr17:37866733chr17:37815303ENST00000541774+727676_12552851241.0Topological domainCytoplasmic
HgeneERBB2chr17:37866734chr17:37815303ENST00000269571+72723_6523001256.0Topological domainExtracellular
HgeneERBB2chr17:37866734chr17:37815303ENST00000269571+727676_12553001256.0Topological domainCytoplasmic
HgeneERBB2chr17:37866734chr17:37815303ENST00000541774+72723_6522851241.0Topological domainExtracellular
HgeneERBB2chr17:37866734chr17:37815303ENST00000541774+727676_12552851241.0Topological domainCytoplasmic
HgeneERBB2chr17:37872858chr17:37816463ENST00000269571+142723_6525791256.0Topological domainExtracellular
HgeneERBB2chr17:37872858chr17:37816463ENST00000269571+1427676_12555791256.0Topological domainCytoplasmic
HgeneERBB2chr17:37872858chr17:37816463ENST00000541774+142723_6525641241.0Topological domainExtracellular
HgeneERBB2chr17:37872858chr17:37816463ENST00000541774+1427676_12555641241.0Topological domainCytoplasmic
HgeneERBB2chr17:37866733chr17:37815303ENST00000269571+727653_6753001256.0TransmembraneHelical
HgeneERBB2chr17:37866733chr17:37815303ENST00000541774+727653_6752851241.0TransmembraneHelical
HgeneERBB2chr17:37866734chr17:37815303ENST00000269571+727653_6753001256.0TransmembraneHelical
HgeneERBB2chr17:37866734chr17:37815303ENST00000541774+727653_6752851241.0TransmembraneHelical
HgeneERBB2chr17:37872858chr17:37816463ENST00000269571+1427653_6755791256.0TransmembraneHelical
HgeneERBB2chr17:37872858chr17:37816463ENST00000541774+1427653_6755641241.0TransmembraneHelical
TgeneSTARD3chr17:37866733chr17:37815303ENST0000033630861546_217215446.0DomainMENTAL
TgeneSTARD3chr17:37866733chr17:37815303ENST0000039425051446_217197428.0DomainMENTAL
TgeneSTARD3chr17:37866733chr17:37815303ENST0000054421061546_217215446.0DomainMENTAL
TgeneSTARD3chr17:37866734chr17:37815303ENST0000033630861546_217215446.0DomainMENTAL
TgeneSTARD3chr17:37866734chr17:37815303ENST0000039425051446_217197428.0DomainMENTAL
TgeneSTARD3chr17:37866734chr17:37815303ENST0000054421061546_217215446.0DomainMENTAL
TgeneSTARD3chr17:37872858chr17:37816463ENST00000336308815230_443265446.0DomainSTART
TgeneSTARD3chr17:37872858chr17:37816463ENST0000033630881546_217265446.0DomainMENTAL
TgeneSTARD3chr17:37872858chr17:37816463ENST00000394250714230_443247428.0DomainSTART
TgeneSTARD3chr17:37872858chr17:37816463ENST0000039425071446_217247428.0DomainMENTAL
TgeneSTARD3chr17:37872858chr17:37816463ENST00000544210815230_443265446.0DomainSTART
TgeneSTARD3chr17:37872858chr17:37816463ENST0000054421081546_217265446.0DomainMENTAL
TgeneSTARD3chr17:37866733chr17:37815303ENST00000336308615207_212215446.0MotifFFAT
TgeneSTARD3chr17:37866733chr17:37815303ENST00000544210615207_212215446.0MotifFFAT
TgeneSTARD3chr17:37866734chr17:37815303ENST00000336308615207_212215446.0MotifFFAT
TgeneSTARD3chr17:37866734chr17:37815303ENST00000544210615207_212215446.0MotifFFAT
TgeneSTARD3chr17:37872858chr17:37816463ENST00000336308815207_212265446.0MotifFFAT
TgeneSTARD3chr17:37872858chr17:37816463ENST00000394250714207_212247428.0MotifFFAT
TgeneSTARD3chr17:37872858chr17:37816463ENST00000544210815207_212265446.0MotifFFAT
TgeneSTARD3chr17:37866733chr17:37815303ENST00000336308615116_120215446.0Topological domainCytoplasmic
TgeneSTARD3chr17:37866733chr17:37815303ENST00000336308615142_148215446.0Topological domainExtracellular
TgeneSTARD3chr17:37866733chr17:37815303ENST00000336308615170_445215446.0Topological domainCytoplasmic
TgeneSTARD3chr17:37866733chr17:37815303ENST000003363086151_51215446.0Topological domainCytoplasmic
TgeneSTARD3chr17:37866733chr17:37815303ENST0000033630861573_94215446.0Topological domainExtracellular
TgeneSTARD3chr17:37866733chr17:37815303ENST00000394250514116_120197428.0Topological domainCytoplasmic
TgeneSTARD3chr17:37866733chr17:37815303ENST00000394250514142_148197428.0Topological domainExtracellular
TgeneSTARD3chr17:37866733chr17:37815303ENST00000394250514170_445197428.0Topological domainCytoplasmic
TgeneSTARD3chr17:37866733chr17:37815303ENST000003942505141_51197428.0Topological domainCytoplasmic
TgeneSTARD3chr17:37866733chr17:37815303ENST0000039425051473_94197428.0Topological domainExtracellular
TgeneSTARD3chr17:37866733chr17:37815303ENST00000544210615116_120215446.0Topological domainCytoplasmic
TgeneSTARD3chr17:37866733chr17:37815303ENST00000544210615142_148215446.0Topological domainExtracellular
TgeneSTARD3chr17:37866733chr17:37815303ENST00000544210615170_445215446.0Topological domainCytoplasmic
TgeneSTARD3chr17:37866733chr17:37815303ENST000005442106151_51215446.0Topological domainCytoplasmic
TgeneSTARD3chr17:37866733chr17:37815303ENST0000054421061573_94215446.0Topological domainExtracellular
TgeneSTARD3chr17:37866734chr17:37815303ENST00000336308615116_120215446.0Topological domainCytoplasmic
TgeneSTARD3chr17:37866734chr17:37815303ENST00000336308615142_148215446.0Topological domainExtracellular
TgeneSTARD3chr17:37866734chr17:37815303ENST00000336308615170_445215446.0Topological domainCytoplasmic
TgeneSTARD3chr17:37866734chr17:37815303ENST000003363086151_51215446.0Topological domainCytoplasmic
TgeneSTARD3chr17:37866734chr17:37815303ENST0000033630861573_94215446.0Topological domainExtracellular
TgeneSTARD3chr17:37866734chr17:37815303ENST00000394250514116_120197428.0Topological domainCytoplasmic
TgeneSTARD3chr17:37866734chr17:37815303ENST00000394250514142_148197428.0Topological domainExtracellular
TgeneSTARD3chr17:37866734chr17:37815303ENST00000394250514170_445197428.0Topological domainCytoplasmic
TgeneSTARD3chr17:37866734chr17:37815303ENST000003942505141_51197428.0Topological domainCytoplasmic
TgeneSTARD3chr17:37866734chr17:37815303ENST0000039425051473_94197428.0Topological domainExtracellular
TgeneSTARD3chr17:37866734chr17:37815303ENST00000544210615116_120215446.0Topological domainCytoplasmic
TgeneSTARD3chr17:37866734chr17:37815303ENST00000544210615142_148215446.0Topological domainExtracellular
TgeneSTARD3chr17:37866734chr17:37815303ENST00000544210615170_445215446.0Topological domainCytoplasmic
TgeneSTARD3chr17:37866734chr17:37815303ENST000005442106151_51215446.0Topological domainCytoplasmic
TgeneSTARD3chr17:37866734chr17:37815303ENST0000054421061573_94215446.0Topological domainExtracellular
TgeneSTARD3chr17:37872858chr17:37816463ENST00000336308815116_120265446.0Topological domainCytoplasmic
TgeneSTARD3chr17:37872858chr17:37816463ENST00000336308815142_148265446.0Topological domainExtracellular
TgeneSTARD3chr17:37872858chr17:37816463ENST00000336308815170_445265446.0Topological domainCytoplasmic
TgeneSTARD3chr17:37872858chr17:37816463ENST000003363088151_51265446.0Topological domainCytoplasmic
TgeneSTARD3chr17:37872858chr17:37816463ENST0000033630881573_94265446.0Topological domainExtracellular
TgeneSTARD3chr17:37872858chr17:37816463ENST00000394250714116_120247428.0Topological domainCytoplasmic
TgeneSTARD3chr17:37872858chr17:37816463ENST00000394250714142_148247428.0Topological domainExtracellular
TgeneSTARD3chr17:37872858chr17:37816463ENST00000394250714170_445247428.0Topological domainCytoplasmic
TgeneSTARD3chr17:37872858chr17:37816463ENST000003942507141_51247428.0Topological domainCytoplasmic
TgeneSTARD3chr17:37872858chr17:37816463ENST0000039425071473_94247428.0Topological domainExtracellular
TgeneSTARD3chr17:37872858chr17:37816463ENST00000544210815116_120265446.0Topological domainCytoplasmic
TgeneSTARD3chr17:37872858chr17:37816463ENST00000544210815142_148265446.0Topological domainExtracellular
TgeneSTARD3chr17:37872858chr17:37816463ENST00000544210815170_445265446.0Topological domainCytoplasmic
TgeneSTARD3chr17:37872858chr17:37816463ENST000005442108151_51265446.0Topological domainCytoplasmic
TgeneSTARD3chr17:37872858chr17:37816463ENST0000054421081573_94265446.0Topological domainExtracellular
TgeneSTARD3chr17:37866733chr17:37815303ENST00000336308615121_141215446.0TransmembraneHelical
TgeneSTARD3chr17:37866733chr17:37815303ENST00000336308615149_169215446.0TransmembraneHelical
TgeneSTARD3chr17:37866733chr17:37815303ENST0000033630861552_72215446.0TransmembraneHelical
TgeneSTARD3chr17:37866733chr17:37815303ENST0000033630861595_115215446.0TransmembraneHelical
TgeneSTARD3chr17:37866733chr17:37815303ENST00000394250514121_141197428.0TransmembraneHelical
TgeneSTARD3chr17:37866733chr17:37815303ENST00000394250514149_169197428.0TransmembraneHelical
TgeneSTARD3chr17:37866733chr17:37815303ENST0000039425051452_72197428.0TransmembraneHelical
TgeneSTARD3chr17:37866733chr17:37815303ENST0000039425051495_115197428.0TransmembraneHelical
TgeneSTARD3chr17:37866733chr17:37815303ENST00000544210615121_141215446.0TransmembraneHelical
TgeneSTARD3chr17:37866733chr17:37815303ENST00000544210615149_169215446.0TransmembraneHelical
TgeneSTARD3chr17:37866733chr17:37815303ENST0000054421061552_72215446.0TransmembraneHelical
TgeneSTARD3chr17:37866733chr17:37815303ENST0000054421061595_115215446.0TransmembraneHelical
TgeneSTARD3chr17:37866734chr17:37815303ENST00000336308615121_141215446.0TransmembraneHelical
TgeneSTARD3chr17:37866734chr17:37815303ENST00000336308615149_169215446.0TransmembraneHelical
TgeneSTARD3chr17:37866734chr17:37815303ENST0000033630861552_72215446.0TransmembraneHelical
TgeneSTARD3chr17:37866734chr17:37815303ENST0000033630861595_115215446.0TransmembraneHelical
TgeneSTARD3chr17:37866734chr17:37815303ENST00000394250514121_141197428.0TransmembraneHelical
TgeneSTARD3chr17:37866734chr17:37815303ENST00000394250514149_169197428.0TransmembraneHelical
TgeneSTARD3chr17:37866734chr17:37815303ENST0000039425051452_72197428.0TransmembraneHelical
TgeneSTARD3chr17:37866734chr17:37815303ENST0000039425051495_115197428.0TransmembraneHelical
TgeneSTARD3chr17:37866734chr17:37815303ENST00000544210615121_141215446.0TransmembraneHelical
TgeneSTARD3chr17:37866734chr17:37815303ENST00000544210615149_169215446.0TransmembraneHelical
TgeneSTARD3chr17:37866734chr17:37815303ENST0000054421061552_72215446.0TransmembraneHelical
TgeneSTARD3chr17:37866734chr17:37815303ENST0000054421061595_115215446.0TransmembraneHelical
TgeneSTARD3chr17:37872858chr17:37816463ENST00000336308815121_141265446.0TransmembraneHelical
TgeneSTARD3chr17:37872858chr17:37816463ENST00000336308815149_169265446.0TransmembraneHelical
TgeneSTARD3chr17:37872858chr17:37816463ENST0000033630881552_72265446.0TransmembraneHelical
TgeneSTARD3chr17:37872858chr17:37816463ENST0000033630881595_115265446.0TransmembraneHelical
TgeneSTARD3chr17:37872858chr17:37816463ENST00000394250714121_141247428.0TransmembraneHelical
TgeneSTARD3chr17:37872858chr17:37816463ENST00000394250714149_169247428.0TransmembraneHelical
TgeneSTARD3chr17:37872858chr17:37816463ENST0000039425071452_72247428.0TransmembraneHelical
TgeneSTARD3chr17:37872858chr17:37816463ENST0000039425071495_115247428.0TransmembraneHelical
TgeneSTARD3chr17:37872858chr17:37816463ENST00000544210815121_141265446.0TransmembraneHelical
TgeneSTARD3chr17:37872858chr17:37816463ENST00000544210815149_169265446.0TransmembraneHelical
TgeneSTARD3chr17:37872858chr17:37816463ENST0000054421081552_72265446.0TransmembraneHelical
TgeneSTARD3chr17:37872858chr17:37816463ENST0000054421081595_115265446.0TransmembraneHelical


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Fusion Gene Sequence for ERBB2-STARD3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ERBB2-STARD3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneERBB2chr17:37866733chr17:37815303ENST00000269571+7271195_1197300.33333333333331256.0PIK3C2B
HgeneERBB2chr17:37866733chr17:37815303ENST00000541774+7271195_1197285.33333333333331241.0PIK3C2B
HgeneERBB2chr17:37866734chr17:37815303ENST00000269571+7271195_1197300.33333333333331256.0PIK3C2B
HgeneERBB2chr17:37866734chr17:37815303ENST00000541774+7271195_1197285.33333333333331241.0PIK3C2B
HgeneERBB2chr17:37872858chr17:37816463ENST00000269571+14271195_1197579.01256.0PIK3C2B
HgeneERBB2chr17:37872858chr17:37816463ENST00000541774+14271195_1197564.01241.0PIK3C2B


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ERBB2-STARD3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ERBB2-STARD3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource