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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ERBB3-COX4I2 (FusionGDB2 ID:27207)

Fusion Gene Summary for ERBB3-COX4I2

check button Fusion gene summary
Fusion gene informationFusion gene name: ERBB3-COX4I2
Fusion gene ID: 27207
HgeneTgene
Gene symbol

ERBB3

COX4I2

Gene ID

2065

84701

Gene nameerb-b2 receptor tyrosine kinase 3cytochrome c oxidase subunit 4I2
SynonymsErbB-3|FERLK|HER3|LCCS2|MDA-BF-1|c-erbB-3|c-erbB3|erbB3-S|p180-ErbB3|p45-sErbB3|p85-sErbB3COX4|COX4-2|COX4B|COX4L2|COXIV-2|dJ857M17.2
Cytomap

12q13.2

20q11.21

Type of geneprotein-codingprotein-coding
Descriptionreceptor tyrosine-protein kinase erbB-3human epidermal growth factor receptor 3proto-oncogene-like protein c-ErbB-3tyrosine kinase-type cell surface receptor HER3v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3cytochrome c oxidase subunit 4 isoform 2, mitochondrialCOX IV-2cytochrome c oxidase subunit IV isoform 2 (lung)cytochrome c oxidase subunit IV-like 2
Modification date2020032720200313
UniProtAcc

P21860

.
Ensembl transtripts involved in fusion geneENST00000267101, ENST00000411731, 
ENST00000415288, ENST00000450146, 
ENST00000549832, ENST00000553131, 
ENST00000490030, ENST00000376075, 
Fusion gene scores* DoF score16 X 18 X 11=31683 X 5 X 3=45
# samples 195
** MAII scorelog2(19/3168*10)=-4.05950101174866
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/45*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ERBB3 [Title/Abstract] AND COX4I2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointERBB3(56474166)-COX4I2(30231207), # samples:3
Anticipated loss of major functional domain due to fusion event.ERBB3-COX4I2 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
ERBB3-COX4I2 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
ERBB3-COX4I2 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
ERBB3-COX4I2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneERBB3

GO:0007162

negative regulation of cell adhesion

7556068

HgeneERBB3

GO:0007165

signal transduction

10572067

HgeneERBB3

GO:0009968

negative regulation of signal transduction

11389077

HgeneERBB3

GO:0014065

phosphatidylinositol 3-kinase signaling

7556068

HgeneERBB3

GO:0042127

regulation of cell proliferation

11389077

HgeneERBB3

GO:0051048

negative regulation of secretion

10559227


check buttonFusion gene breakpoints across ERBB3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across COX4I2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-AJ-A3I9-01AERBB3chr12

56474166

-COX4I2chr20

30231207

+
ChimerDB4UCECTCGA-AJ-A3I9-01AERBB3chr12

56474166

+COX4I2chr20

30231207

+
ChimerDB4UCECTCGA-AJ-A3I9-01AERBB3chr12

56474166

+COX4I2chr20

30232571

+
ChimerDB4UCECTCGA-AJ-A3I9ERBB3chr12

56474166

+COX4I2chr20

30231206

+


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Fusion Gene ORF analysis for ERBB3-COX4I2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000267101ENST00000490030ERBB3chr12

56474166

+COX4I2chr20

30232571

+
5CDS-3UTRENST00000411731ENST00000490030ERBB3chr12

56474166

+COX4I2chr20

30232571

+
5CDS-intronENST00000267101ENST00000490030ERBB3chr12

56474166

+COX4I2chr20

30231207

+
5CDS-intronENST00000267101ENST00000490030ERBB3chr12

56474166

+COX4I2chr20

30231206

+
5CDS-intronENST00000411731ENST00000490030ERBB3chr12

56474166

+COX4I2chr20

30231207

+
5CDS-intronENST00000411731ENST00000490030ERBB3chr12

56474166

+COX4I2chr20

30231206

+
Frame-shiftENST00000267101ENST00000376075ERBB3chr12

56474166

+COX4I2chr20

30232571

+
Frame-shiftENST00000411731ENST00000376075ERBB3chr12

56474166

+COX4I2chr20

30232571

+
In-frameENST00000267101ENST00000376075ERBB3chr12

56474166

+COX4I2chr20

30231207

+
In-frameENST00000267101ENST00000376075ERBB3chr12

56474166

+COX4I2chr20

30231206

+
In-frameENST00000411731ENST00000376075ERBB3chr12

56474166

+COX4I2chr20

30231207

+
In-frameENST00000411731ENST00000376075ERBB3chr12

56474166

+COX4I2chr20

30231206

+
intron-3CDSENST00000415288ENST00000376075ERBB3chr12

56474166

+COX4I2chr20

30231207

+
intron-3CDSENST00000415288ENST00000376075ERBB3chr12

56474166

+COX4I2chr20

30232571

+
intron-3CDSENST00000415288ENST00000376075ERBB3chr12

56474166

+COX4I2chr20

30231206

+
intron-3CDSENST00000450146ENST00000376075ERBB3chr12

56474166

+COX4I2chr20

30231207

+
intron-3CDSENST00000450146ENST00000376075ERBB3chr12

56474166

+COX4I2chr20

30232571

+
intron-3CDSENST00000450146ENST00000376075ERBB3chr12

56474166

+COX4I2chr20

30231206

+
intron-3CDSENST00000549832ENST00000376075ERBB3chr12

56474166

+COX4I2chr20

30231207

+
intron-3CDSENST00000549832ENST00000376075ERBB3chr12

56474166

+COX4I2chr20

30232571

+
intron-3CDSENST00000549832ENST00000376075ERBB3chr12

56474166

+COX4I2chr20

30231206

+
intron-3CDSENST00000553131ENST00000376075ERBB3chr12

56474166

+COX4I2chr20

30231207

+
intron-3CDSENST00000553131ENST00000376075ERBB3chr12

56474166

+COX4I2chr20

30232571

+
intron-3CDSENST00000553131ENST00000376075ERBB3chr12

56474166

+COX4I2chr20

30231206

+
intron-3UTRENST00000415288ENST00000490030ERBB3chr12

56474166

+COX4I2chr20

30232571

+
intron-3UTRENST00000450146ENST00000490030ERBB3chr12

56474166

+COX4I2chr20

30232571

+
intron-3UTRENST00000549832ENST00000490030ERBB3chr12

56474166

+COX4I2chr20

30232571

+
intron-3UTRENST00000553131ENST00000490030ERBB3chr12

56474166

+COX4I2chr20

30232571

+
intron-intronENST00000415288ENST00000490030ERBB3chr12

56474166

+COX4I2chr20

30231207

+
intron-intronENST00000415288ENST00000490030ERBB3chr12

56474166

+COX4I2chr20

30231206

+
intron-intronENST00000450146ENST00000490030ERBB3chr12

56474166

+COX4I2chr20

30231207

+
intron-intronENST00000450146ENST00000490030ERBB3chr12

56474166

+COX4I2chr20

30231206

+
intron-intronENST00000549832ENST00000490030ERBB3chr12

56474166

+COX4I2chr20

30231207

+
intron-intronENST00000549832ENST00000490030ERBB3chr12

56474166

+COX4I2chr20

30231206

+
intron-intronENST00000553131ENST00000490030ERBB3chr12

56474166

+COX4I2chr20

30231207

+
intron-intronENST00000553131ENST00000490030ERBB3chr12

56474166

+COX4I2chr20

30231206

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000267101ERBB3chr1256474166+ENST00000376075COX4I2chr2030231207+893522874245209
ENST00000411731ERBB3chr1256474166+ENST00000376075COX4I2chr2030231207+6172465982199
ENST00000267101ERBB3chr1256474166+ENST00000376075COX4I2chr2030231206+893522874245209
ENST00000411731ERBB3chr1256474166+ENST00000376075COX4I2chr2030231206+6172465982199

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000267101ENST00000376075ERBB3chr1256474166+COX4I2chr2030231207+0.0326493870.9673506
ENST00000411731ENST00000376075ERBB3chr1256474166+COX4I2chr2030231207+0.020707370.97929263
ENST00000267101ENST00000376075ERBB3chr1256474166+COX4I2chr2030231206+0.0326493870.9673506
ENST00000411731ENST00000376075ERBB3chr1256474166+COX4I2chr2030231206+0.020707370.97929263

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Fusion Genomic Features for ERBB3-COX4I2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ERBB3chr1256474166+COX4I2chr2030231206+4.55E-081
ERBB3chr1256474166+COX4I2chr2030231206+4.55E-081
ERBB3chr1256474166+COX4I2chr2030232570+1.77E-111
ERBB3chr1256474166+COX4I2chr2030231206+4.55E-081
ERBB3chr1256474166+COX4I2chr2030231206+4.55E-081
ERBB3chr1256474166+COX4I2chr2030232570+1.77E-111

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ERBB3-COX4I2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:56474166/chr20:30231207)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ERBB3

P21860

.
FUNCTION: Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778). May also be activated by CSPG5 (PubMed:15358134). Involved in the regulation of myeloid cell differentiation (PubMed:27416908). {ECO:0000269|PubMed:15358134, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:27416908}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCOX4I2chr12:56474166chr20:30231206ENST0000037607525127_17182172.0Topological domainMitochondrial intermembrane
TgeneCOX4I2chr12:56474166chr20:30231207ENST0000037607525127_17182172.0Topological domainMitochondrial intermembrane
TgeneCOX4I2chr12:56474166chr20:30231206ENST0000037607525101_12682172.0TransmembraneHelical
TgeneCOX4I2chr12:56474166chr20:30231207ENST0000037607525101_12682172.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneERBB3chr12:56474166chr20:30231206ENST00000267101+128709_966271343.0DomainProtein kinase
HgeneERBB3chr12:56474166chr20:30231206ENST00000411731+13709_96627184.0DomainProtein kinase
HgeneERBB3chr12:56474166chr20:30231206ENST00000415288+129709_96601284.0DomainProtein kinase
HgeneERBB3chr12:56474166chr20:30231206ENST00000450146+115709_9660700.0DomainProtein kinase
HgeneERBB3chr12:56474166chr20:30231207ENST00000267101+128709_966271343.0DomainProtein kinase
HgeneERBB3chr12:56474166chr20:30231207ENST00000411731+13709_96627184.0DomainProtein kinase
HgeneERBB3chr12:56474166chr20:30231207ENST00000415288+129709_96601284.0DomainProtein kinase
HgeneERBB3chr12:56474166chr20:30231207ENST00000450146+115709_9660700.0DomainProtein kinase
HgeneERBB3chr12:56474166chr20:30231206ENST00000267101+128715_723271343.0Nucleotide bindingNote=ATP
HgeneERBB3chr12:56474166chr20:30231206ENST00000267101+128788_790271343.0Nucleotide bindingNote=ATP
HgeneERBB3chr12:56474166chr20:30231206ENST00000267101+128834_839271343.0Nucleotide bindingNote=ATP
HgeneERBB3chr12:56474166chr20:30231206ENST00000411731+13715_72327184.0Nucleotide bindingNote=ATP
HgeneERBB3chr12:56474166chr20:30231206ENST00000411731+13788_79027184.0Nucleotide bindingNote=ATP
HgeneERBB3chr12:56474166chr20:30231206ENST00000411731+13834_83927184.0Nucleotide bindingNote=ATP
HgeneERBB3chr12:56474166chr20:30231206ENST00000415288+129715_72301284.0Nucleotide bindingNote=ATP
HgeneERBB3chr12:56474166chr20:30231206ENST00000415288+129788_79001284.0Nucleotide bindingNote=ATP
HgeneERBB3chr12:56474166chr20:30231206ENST00000415288+129834_83901284.0Nucleotide bindingNote=ATP
HgeneERBB3chr12:56474166chr20:30231206ENST00000450146+115715_7230700.0Nucleotide bindingNote=ATP
HgeneERBB3chr12:56474166chr20:30231206ENST00000450146+115788_7900700.0Nucleotide bindingNote=ATP
HgeneERBB3chr12:56474166chr20:30231206ENST00000450146+115834_8390700.0Nucleotide bindingNote=ATP
HgeneERBB3chr12:56474166chr20:30231207ENST00000267101+128715_723271343.0Nucleotide bindingNote=ATP
HgeneERBB3chr12:56474166chr20:30231207ENST00000267101+128788_790271343.0Nucleotide bindingNote=ATP
HgeneERBB3chr12:56474166chr20:30231207ENST00000267101+128834_839271343.0Nucleotide bindingNote=ATP
HgeneERBB3chr12:56474166chr20:30231207ENST00000411731+13715_72327184.0Nucleotide bindingNote=ATP
HgeneERBB3chr12:56474166chr20:30231207ENST00000411731+13788_79027184.0Nucleotide bindingNote=ATP
HgeneERBB3chr12:56474166chr20:30231207ENST00000411731+13834_83927184.0Nucleotide bindingNote=ATP
HgeneERBB3chr12:56474166chr20:30231207ENST00000415288+129715_72301284.0Nucleotide bindingNote=ATP
HgeneERBB3chr12:56474166chr20:30231207ENST00000415288+129788_79001284.0Nucleotide bindingNote=ATP
HgeneERBB3chr12:56474166chr20:30231207ENST00000415288+129834_83901284.0Nucleotide bindingNote=ATP
HgeneERBB3chr12:56474166chr20:30231207ENST00000450146+115715_7230700.0Nucleotide bindingNote=ATP
HgeneERBB3chr12:56474166chr20:30231207ENST00000450146+115788_7900700.0Nucleotide bindingNote=ATP
HgeneERBB3chr12:56474166chr20:30231207ENST00000450146+115834_8390700.0Nucleotide bindingNote=ATP
HgeneERBB3chr12:56474166chr20:30231206ENST00000267101+12820_643271343.0Topological domainExtracellular
HgeneERBB3chr12:56474166chr20:30231206ENST00000267101+128665_1342271343.0Topological domainCytoplasmic
HgeneERBB3chr12:56474166chr20:30231206ENST00000411731+1320_64327184.0Topological domainExtracellular
HgeneERBB3chr12:56474166chr20:30231206ENST00000411731+13665_134227184.0Topological domainCytoplasmic
HgeneERBB3chr12:56474166chr20:30231206ENST00000415288+12920_64301284.0Topological domainExtracellular
HgeneERBB3chr12:56474166chr20:30231206ENST00000415288+129665_134201284.0Topological domainCytoplasmic
HgeneERBB3chr12:56474166chr20:30231206ENST00000450146+11520_6430700.0Topological domainExtracellular
HgeneERBB3chr12:56474166chr20:30231206ENST00000450146+115665_13420700.0Topological domainCytoplasmic
HgeneERBB3chr12:56474166chr20:30231207ENST00000267101+12820_643271343.0Topological domainExtracellular
HgeneERBB3chr12:56474166chr20:30231207ENST00000267101+128665_1342271343.0Topological domainCytoplasmic
HgeneERBB3chr12:56474166chr20:30231207ENST00000411731+1320_64327184.0Topological domainExtracellular
HgeneERBB3chr12:56474166chr20:30231207ENST00000411731+13665_134227184.0Topological domainCytoplasmic
HgeneERBB3chr12:56474166chr20:30231207ENST00000415288+12920_64301284.0Topological domainExtracellular
HgeneERBB3chr12:56474166chr20:30231207ENST00000415288+129665_134201284.0Topological domainCytoplasmic
HgeneERBB3chr12:56474166chr20:30231207ENST00000450146+11520_6430700.0Topological domainExtracellular
HgeneERBB3chr12:56474166chr20:30231207ENST00000450146+115665_13420700.0Topological domainCytoplasmic
HgeneERBB3chr12:56474166chr20:30231206ENST00000267101+128644_664271343.0TransmembraneHelical
HgeneERBB3chr12:56474166chr20:30231206ENST00000411731+13644_66427184.0TransmembraneHelical
HgeneERBB3chr12:56474166chr20:30231206ENST00000415288+129644_66401284.0TransmembraneHelical
HgeneERBB3chr12:56474166chr20:30231206ENST00000450146+115644_6640700.0TransmembraneHelical
HgeneERBB3chr12:56474166chr20:30231207ENST00000267101+128644_664271343.0TransmembraneHelical
HgeneERBB3chr12:56474166chr20:30231207ENST00000411731+13644_66427184.0TransmembraneHelical
HgeneERBB3chr12:56474166chr20:30231207ENST00000415288+129644_66401284.0TransmembraneHelical
HgeneERBB3chr12:56474166chr20:30231207ENST00000450146+115644_6640700.0TransmembraneHelical
TgeneCOX4I2chr12:56474166chr20:30231206ENST000003760752529_10082172.0Topological domainMitochondrial matrix
TgeneCOX4I2chr12:56474166chr20:30231207ENST000003760752529_10082172.0Topological domainMitochondrial matrix


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Fusion Gene Sequence for ERBB3-COX4I2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>27207_27207_1_ERBB3-COX4I2_ERBB3_chr12_56474166_ENST00000267101_COX4I2_chr20_30231206_ENST00000376075_length(transcript)=893nt_BP=522nt
ATTACCCTTCCCTGGATCTGGGGGCTTTCGGAATCTCGACCTCCCCTTGGCCTATCTCCTGCAGAAAAATTAGGGTGAGCCCCATCCTCG
ATCTGCTCCGCCAAGTTGCGGGACCGCGGGGCGTGGCACGCTCGGGGCAGGCGGTCCGAGGCTCCGCAATCCCTACTCCAGCCTCGCGCG
GGAGGGGGCGCGGCCGTGACTCACCCCCTTCCCTCTGCGTTCCTCCCTCCCTCTCTCTCTCTCTCTCACACACACACACCCCTCCCCTGC
CATCCCTCCCCGGACTCCGGCTCCGGCTCCGATTGCAATTTGCAACCTCCGCTGCCGTCGCCGCAGCAGCCACCAATTCGCCAGCGGTTC
AGGTGGCTCTTGCCTCGATGTCCTAGCCTAGGGGCCCCCGGGCCGGACTTGGCTGGGCTCCCTTCACCCTCTGCGGAGTCATGAGGGCGA
ACGACGCTCTGCAGGTGCTGGGCTTGCTTTTCAGCCTGGCCCGGGGCTCCGAGGTGGGCAACTCTCAGGCAGTGTACCGGCTCCAGTTCA
ATGAGACCTTTGCGGAGATGAACCGTCGCTCCAATGAGTGGAAGACAGTGATGGGTTGTGTCTTCTTCTTCATTGGATTCGCAGCTCTGG
TGATTTGGTGGCAGCGGGTCTACGTATTTCCTCCAAAGCCGATCACCTTGACGGACGAGCGGAAAGCCCAGCAGCTGCAGCGCATGCTGG
ACATGAAGGTGAATCCTGTGCAGGGCCTGGCCTCCCGCTGGGACTATGAGAAGAAGCAGTGGAAGAAGTGACTTGCATCCCCAGCTGTCT

>27207_27207_1_ERBB3-COX4I2_ERBB3_chr12_56474166_ENST00000267101_COX4I2_chr20_30231206_ENST00000376075_length(amino acids)=209AA_BP=1
MGLRAGEGRGRQRLPARAEPQGDSWGCKSLLPLLLLIVPAGGQALHRIHLHVQHALQLLGFPLVRQGDRLWRKYVDPLPPNHQSCESNEE
EDTTHHCLPLIGATVHLRKGLIELEPVHCLRVAHLGAPGQAEKQAQHLQSVVRPHDSAEGEGSPAKSGPGAPRLGHRGKSHLNRWRIGGC

--------------------------------------------------------------
>27207_27207_2_ERBB3-COX4I2_ERBB3_chr12_56474166_ENST00000267101_COX4I2_chr20_30231207_ENST00000376075_length(transcript)=893nt_BP=522nt
ATTACCCTTCCCTGGATCTGGGGGCTTTCGGAATCTCGACCTCCCCTTGGCCTATCTCCTGCAGAAAAATTAGGGTGAGCCCCATCCTCG
ATCTGCTCCGCCAAGTTGCGGGACCGCGGGGCGTGGCACGCTCGGGGCAGGCGGTCCGAGGCTCCGCAATCCCTACTCCAGCCTCGCGCG
GGAGGGGGCGCGGCCGTGACTCACCCCCTTCCCTCTGCGTTCCTCCCTCCCTCTCTCTCTCTCTCTCACACACACACACCCCTCCCCTGC
CATCCCTCCCCGGACTCCGGCTCCGGCTCCGATTGCAATTTGCAACCTCCGCTGCCGTCGCCGCAGCAGCCACCAATTCGCCAGCGGTTC
AGGTGGCTCTTGCCTCGATGTCCTAGCCTAGGGGCCCCCGGGCCGGACTTGGCTGGGCTCCCTTCACCCTCTGCGGAGTCATGAGGGCGA
ACGACGCTCTGCAGGTGCTGGGCTTGCTTTTCAGCCTGGCCCGGGGCTCCGAGGTGGGCAACTCTCAGGCAGTGTACCGGCTCCAGTTCA
ATGAGACCTTTGCGGAGATGAACCGTCGCTCCAATGAGTGGAAGACAGTGATGGGTTGTGTCTTCTTCTTCATTGGATTCGCAGCTCTGG
TGATTTGGTGGCAGCGGGTCTACGTATTTCCTCCAAAGCCGATCACCTTGACGGACGAGCGGAAAGCCCAGCAGCTGCAGCGCATGCTGG
ACATGAAGGTGAATCCTGTGCAGGGCCTGGCCTCCCGCTGGGACTATGAGAAGAAGCAGTGGAAGAAGTGACTTGCATCCCCAGCTGTCT

>27207_27207_2_ERBB3-COX4I2_ERBB3_chr12_56474166_ENST00000267101_COX4I2_chr20_30231207_ENST00000376075_length(amino acids)=209AA_BP=1
MGLRAGEGRGRQRLPARAEPQGDSWGCKSLLPLLLLIVPAGGQALHRIHLHVQHALQLLGFPLVRQGDRLWRKYVDPLPPNHQSCESNEE
EDTTHHCLPLIGATVHLRKGLIELEPVHCLRVAHLGAPGQAEKQAQHLQSVVRPHDSAEGEGSPAKSGPGAPRLGHRGKSHLNRWRIGGC

--------------------------------------------------------------
>27207_27207_3_ERBB3-COX4I2_ERBB3_chr12_56474166_ENST00000411731_COX4I2_chr20_30231206_ENST00000376075_length(transcript)=617nt_BP=246nt
TCCCCGGACTCCGGCTCCGGCTCCGATTGCAATTTGCAACCTCCGCTGCCGTCGCCGCAGCAGCCACCAATTCGCCAGCGGTTCAGGTGG
CTCTTGCCTCGATGTCCTAGCCTAGGGGCCCCCGGGCCGGACTTGGCTGGGCTCCCTTCACCCTCTGCGGAGTCATGAGGGCGAACGACG
CTCTGCAGGTGCTGGGCTTGCTTTTCAGCCTGGCCCGGGGCTCCGAGGTGGGCAACTCTCAGGCAGTGTACCGGCTCCAGTTCAATGAGA
CCTTTGCGGAGATGAACCGTCGCTCCAATGAGTGGAAGACAGTGATGGGTTGTGTCTTCTTCTTCATTGGATTCGCAGCTCTGGTGATTT
GGTGGCAGCGGGTCTACGTATTTCCTCCAAAGCCGATCACCTTGACGGACGAGCGGAAAGCCCAGCAGCTGCAGCGCATGCTGGACATGA
AGGTGAATCCTGTGCAGGGCCTGGCCTCCCGCTGGGACTATGAGAAGAAGCAGTGGAAGAAGTGACTTGCATCCCCAGCTGTCTCCCTGA

>27207_27207_3_ERBB3-COX4I2_ERBB3_chr12_56474166_ENST00000411731_COX4I2_chr20_30231206_ENST00000376075_length(amino acids)=199AA_BP=1
MGLRAGEGRGRQRLPARAEPQGDSWGCKSLLPLLLLIVPAGGQALHRIHLHVQHALQLLGFPLVRQGDRLWRKYVDPLPPNHQSCESNEE
EDTTHHCLPLIGATVHLRKGLIELEPVHCLRVAHLGAPGQAEKQAQHLQSVVRPHDSAEGEGSPAKSGPGAPRLGHRGKSHLNRWRIGGC

--------------------------------------------------------------
>27207_27207_4_ERBB3-COX4I2_ERBB3_chr12_56474166_ENST00000411731_COX4I2_chr20_30231207_ENST00000376075_length(transcript)=617nt_BP=246nt
TCCCCGGACTCCGGCTCCGGCTCCGATTGCAATTTGCAACCTCCGCTGCCGTCGCCGCAGCAGCCACCAATTCGCCAGCGGTTCAGGTGG
CTCTTGCCTCGATGTCCTAGCCTAGGGGCCCCCGGGCCGGACTTGGCTGGGCTCCCTTCACCCTCTGCGGAGTCATGAGGGCGAACGACG
CTCTGCAGGTGCTGGGCTTGCTTTTCAGCCTGGCCCGGGGCTCCGAGGTGGGCAACTCTCAGGCAGTGTACCGGCTCCAGTTCAATGAGA
CCTTTGCGGAGATGAACCGTCGCTCCAATGAGTGGAAGACAGTGATGGGTTGTGTCTTCTTCTTCATTGGATTCGCAGCTCTGGTGATTT
GGTGGCAGCGGGTCTACGTATTTCCTCCAAAGCCGATCACCTTGACGGACGAGCGGAAAGCCCAGCAGCTGCAGCGCATGCTGGACATGA
AGGTGAATCCTGTGCAGGGCCTGGCCTCCCGCTGGGACTATGAGAAGAAGCAGTGGAAGAAGTGACTTGCATCCCCAGCTGTCTCCCTGA

>27207_27207_4_ERBB3-COX4I2_ERBB3_chr12_56474166_ENST00000411731_COX4I2_chr20_30231207_ENST00000376075_length(amino acids)=199AA_BP=1
MGLRAGEGRGRQRLPARAEPQGDSWGCKSLLPLLLLIVPAGGQALHRIHLHVQHALQLLGFPLVRQGDRLWRKYVDPLPPNHQSCESNEE
EDTTHHCLPLIGATVHLRKGLIELEPVHCLRVAHLGAPGQAEKQAQHLQSVVRPHDSAEGEGSPAKSGPGAPRLGHRGKSHLNRWRIGGC

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ERBB3-COX4I2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ERBB3-COX4I2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ERBB3-COX4I2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource