FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:ERC1-VWF (FusionGDB2 ID:27285)

Fusion Gene Summary for ERC1-VWF

check button Fusion gene summary
Fusion gene informationFusion gene name: ERC1-VWF
Fusion gene ID: 27285
HgeneTgene
Gene symbol

ERC1

VWF

Gene ID

23085

7450

Gene nameELKS/RAB6-interacting/CAST family member 1von Willebrand factor
SynonymsCast2|ELKS|ERC-1|RAB6IP2F8VWF|VWD
Cytomap

12p13.33

12p13.31

Type of geneprotein-codingprotein-coding
DescriptionELKS/Rab6-interacting/CAST family member 1RAB6 interacting protein 2von Willebrand factorcoagulation factor VIII VWF
Modification date2020031320200329
UniProtAcc

Q8IUD2

.
Ensembl transtripts involved in fusion geneENST00000355446, ENST00000360905, 
ENST00000397203, ENST00000543086, 
ENST00000546231, ENST00000589028, 
ENST00000536573, 		ENST00000545906, 
ENST00000572068, ENST00000261405, 
Fusion gene scores* DoF score32 X 23 X 16=117764 X 4 X 3=48
# samples 385
** MAII scorelog2(38/11776*10)=-4.95370634772607
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ERC1 [Title/Abstract] AND VWF [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointERC1(1372331)-VWF(6085426), # samples:4
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneERC1

GO:0007252

I-kappaB phosphorylation

15218148

TgeneVWF

GO:0007155

cell adhesion

10764791

TgeneVWF

GO:0030168

platelet activation

8565074

TgeneVWF

GO:0031589

cell-substrate adhesion

9079671


check buttonFusion gene breakpoints across ERC1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across VWF (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-05-4415-01AERC1chr12

1372331

-VWFchr12

6085426

-
ChimerDB4LUADTCGA-05-4415-01AERC1chr12

1372331

+VWFchr12

6085426

-
ChimerDB4LUADTCGA-05-4415ERC1chr12

1372331

+VWFchr12

6085426

-


Top

Fusion Gene ORF analysis for ERC1-VWF

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000355446ENST00000545906ERC1chr12

1372331

+VWFchr12

6085426

-
5CDS-intronENST00000355446ENST00000572068ERC1chr12

1372331

+VWFchr12

6085426

-
5CDS-intronENST00000360905ENST00000545906ERC1chr12

1372331

+VWFchr12

6085426

-
5CDS-intronENST00000360905ENST00000572068ERC1chr12

1372331

+VWFchr12

6085426

-
5CDS-intronENST00000397203ENST00000545906ERC1chr12

1372331

+VWFchr12

6085426

-
5CDS-intronENST00000397203ENST00000572068ERC1chr12

1372331

+VWFchr12

6085426

-
5CDS-intronENST00000543086ENST00000545906ERC1chr12

1372331

+VWFchr12

6085426

-
5CDS-intronENST00000543086ENST00000572068ERC1chr12

1372331

+VWFchr12

6085426

-
5CDS-intronENST00000546231ENST00000545906ERC1chr12

1372331

+VWFchr12

6085426

-
5CDS-intronENST00000546231ENST00000572068ERC1chr12

1372331

+VWFchr12

6085426

-
5CDS-intronENST00000589028ENST00000545906ERC1chr12

1372331

+VWFchr12

6085426

-
5CDS-intronENST00000589028ENST00000572068ERC1chr12

1372331

+VWFchr12

6085426

-
In-frameENST00000355446ENST00000261405ERC1chr12

1372331

+VWFchr12

6085426

-
In-frameENST00000360905ENST00000261405ERC1chr12

1372331

+VWFchr12

6085426

-
In-frameENST00000397203ENST00000261405ERC1chr12

1372331

+VWFchr12

6085426

-
In-frameENST00000543086ENST00000261405ERC1chr12

1372331

+VWFchr12

6085426

-
In-frameENST00000546231ENST00000261405ERC1chr12

1372331

+VWFchr12

6085426

-
In-frameENST00000589028ENST00000261405ERC1chr12

1372331

+VWFchr12

6085426

-
intron-3CDSENST00000536573ENST00000261405ERC1chr12

1372331

+VWFchr12

6085426

-
intron-intronENST00000536573ENST00000545906ERC1chr12

1372331

+VWFchr12

6085426

-
intron-intronENST00000536573ENST00000572068ERC1chr12

1372331

+VWFchr12

6085426

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000543086ERC1chr121372331+ENST00000261405VWFchr126085426-4102280627139601229
ENST00000546231ERC1chr121372331+ENST00000261405VWFchr126085426-4455315952843131261
ENST00000397203ERC1chr121372331+ENST00000261405VWFchr126085426-4321302540641791257
ENST00000360905ERC1chr121372331+ENST00000261405VWFchr126085426-4096280018139541257
ENST00000589028ERC1chr121372331+ENST00000261405VWFchr126085426-4072277615739301257
ENST00000355446ERC1chr121372331+ENST00000261405VWFchr126085426-4047275113239051257

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000543086ENST00000261405ERC1chr121372331+VWFchr126085426-0.0029070710.99709296
ENST00000546231ENST00000261405ERC1chr121372331+VWFchr126085426-0.0058317520.9941683
ENST00000397203ENST00000261405ERC1chr121372331+VWFchr126085426-0.0024936540.9975063
ENST00000360905ENST00000261405ERC1chr121372331+VWFchr126085426-0.0021801640.9978198
ENST00000589028ENST00000261405ERC1chr121372331+VWFchr126085426-0.0019206980.9980793
ENST00000355446ENST00000261405ERC1chr121372331+VWFchr126085426-0.0020254480.9979746

Top

Fusion Genomic Features for ERC1-VWF


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for ERC1-VWF


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:1372331/chr12:6085426)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ERC1

Q8IUD2

.
FUNCTION: Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex. May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport. {ECO:0000269|PubMed:15218148}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneVWFchr12:1372331chr12:6085426ENST0000026140541522429_249524292814.0DomainVWFC 2
TgeneVWFchr12:1372331chr12:6085426ENST0000026140541522580_264524292814.0DomainVWFC 3
TgeneVWFchr12:1372331chr12:6085426ENST0000026140541522724_281224292814.0DomainCTCK
TgeneVWFchr12:1372331chr12:6085426ENST0000026140541522507_250924292814.0MotifNote=Cell attachment site

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneERC1chr12:1372331chr12:6085426ENST00000360905+14191060_11008731117.0Coiled coilOntology_term=ECO:0000255
HgeneERC1chr12:1372331chr12:6085426ENST00000360905+1419144_9888731117.0Coiled coilOntology_term=ECO:0000255
HgeneERC1chr12:1372331chr12:6085426ENST00000397203+14191060_11008731117.0Coiled coilOntology_term=ECO:0000255
HgeneERC1chr12:1372331chr12:6085426ENST00000397203+1419144_9888731117.0Coiled coilOntology_term=ECO:0000255
HgeneERC1chr12:1372331chr12:6085426ENST00000543086+13181060_11008451089.0Coiled coilOntology_term=ECO:0000255
HgeneERC1chr12:1372331chr12:6085426ENST00000543086+1318144_9888451089.0Coiled coilOntology_term=ECO:0000255
HgeneERC1chr12:1372331chr12:6085426ENST00000589028+13181060_11008731117.0Coiled coilOntology_term=ECO:0000255
HgeneERC1chr12:1372331chr12:6085426ENST00000589028+1318144_9888731117.0Coiled coilOntology_term=ECO:0000255
HgeneERC1chr12:1372331chr12:6085426ENST00000360905+14191046_11088731117.0DomainFIP-RBD
HgeneERC1chr12:1372331chr12:6085426ENST00000397203+14191046_11088731117.0DomainFIP-RBD
HgeneERC1chr12:1372331chr12:6085426ENST00000543086+13181046_11088451089.0DomainFIP-RBD
HgeneERC1chr12:1372331chr12:6085426ENST00000589028+13181046_11088731117.0DomainFIP-RBD
TgeneVWFchr12:1372331chr12:6085426ENST0000026140541521146_119624292814.0DomainNote=TIL 4
TgeneVWFchr12:1372331chr12:6085426ENST0000026140541521277_145324292814.0DomainVWFA 1%3B binding site for platelet glycoprotein Ib
TgeneVWFchr12:1372331chr12:6085426ENST0000026140541521498_166524292814.0DomainVWFA 2
TgeneVWFchr12:1372331chr12:6085426ENST0000026140541521691_187124292814.0DomainVWFA 3%3B main binding site for collagens type I and III
TgeneVWFchr12:1372331chr12:6085426ENST0000026140541521949_215324292814.0DomainVWFD 4
TgeneVWFchr12:1372331chr12:6085426ENST0000026140541522255_232824292814.0DomainVWFC 1
TgeneVWFchr12:1372331chr12:6085426ENST000002614054152295_34824292814.0DomainNote=TIL 1
TgeneVWFchr12:1372331chr12:6085426ENST00000261405415234_24024292814.0DomainVWFD 1
TgeneVWFchr12:1372331chr12:6085426ENST000002614054152387_59824292814.0DomainVWFD 2
TgeneVWFchr12:1372331chr12:6085426ENST000002614054152652_70724292814.0DomainNote=TIL 2
TgeneVWFchr12:1372331chr12:6085426ENST000002614054152776_82724292814.0DomainNote=TIL 3
TgeneVWFchr12:1372331chr12:6085426ENST000002614054152866_107424292814.0DomainVWFD 3
TgeneVWFchr12:1372331chr12:6085426ENST0000026140541522216_226124292814.0RegionNote=E2
TgeneVWFchr12:1372331chr12:6085426ENST000002614054152764_78724292814.0RegionNote=Amino-terminal
TgeneVWFchr12:1372331chr12:6085426ENST000002614054152788_83324292814.0RegionNote=E1
TgeneVWFchr12:1372331chr12:6085426ENST000002614054152826_85324292814.0RegionNote=CX


Top

Fusion Gene Sequence for ERC1-VWF


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>27285_27285_1_ERC1-VWF_ERC1_chr12_1372331_ENST00000355446_VWF_chr12_6085426_ENST00000261405_length(transcript)=4047nt_BP=2751nt
GATTGGACAGCTGGGGACCTTCTTCTGATTAACCTTAAACCAACTTGTAGCCATAGAGACACCTCACAAGGTTCCCATTTTTGTTGTTGT
TGTTGTTGATTTTCTGCTCACACCTTTCCTGACCTTGCAACCATGTATGGAAGTGCCCGCTCTGTTGGGAAGGTGGAGCCGAGCAGCCAG
AGCCCTGGGCGTTCACCCAGGCTTCCACGTTCCCCTCGCTTGGGTCACCGTCGAACCAACAGTACGGGAGGGAGTTCGGGAAGCAGTGTT
GGAGGTGGCAGTGGGAAAACCCTTTCAATGGAAAATATACAATCTTTAAATGCTGCCTATGCCACCTCTGGCCCTATGTATCTAAGTGAC
CATGAAAATGTGGGTTCAGAAACACCTAAAAGCACCATGACACTTGGCCGTTCTGGGGGACGTCTGCCTTACGGTGTTCGGATGACTGCT
ATGGGTAGTAGCCCCAATATAGCTAGCAGTGGGGTTGCTAGTGACACCATAGCATTTGGAGAGCATCACCTCCCTCCTGTGAGTATGGCA
TCCACTGTACCTCACTCCCTTCGTCAGGCGAGAGATAACACAATCATGGATCTGCAGACACAGCTGAAGGAAGTATTAAGAGAAAATGAT
CTCTTGCGGAAGGATGTGGAAGTAAAGGAGAGCAAATTGAGTTCTTCAATGAATAGCATCAAGACCTTCTGGAGCCCAGAGCTGAAGAAG
GAACGAGCCCTGAGAAAAGATGAAGCTTCCAAAATCACCATTTGGAAGGAACAGTACAGAGTTGTACAGGAGGAAAACCAGCACATGCAG
ATGACAATCCAGGCTCTCCAGGATGAATTGCGGATCCAGAGGGACCTGAATCAGCTGTTTCAGCAGGATAGTAGCAGCAGGACTGGCGAA
CCTTGTGTAGCAGAGCTGACAGAGGAGAACTTTCAGAGGCTTCATGCTGAGCATGAGCGGCAGGCCAAAGAGCTGTTTCTTCTTCGAAAG
ACATTGGAGGAAATGGAGCTGCGTATTGAGACTCAAAAGCAGACCCTAAATGCTCGGGATGAATCCATTAAGAAGCTTCTGGAAATGTTG
CAGAGCAAAGGACTTTCTGCCAAGGCTACCGAGGAAGACCATGAGAGAACAAGACGACTGGCAGAGGCAGAGATGCACGTTCATCACCTA
GAAAGCCTTTTGGAGCAGAAGGAAAAAGAGAACAGTATGTTGAGAGAGGAGATGCATCGAAGGTTTGAGAATGCTCCTGATTCTGCCAAA
ACAAAAGCTCTGCAAACTGTTATTGAGATGAAGGATTCAAAAATTTCCTCTATGGAGCGTGGGCTTCGAGACCTGGAAGAGGAAATTCAG
ATGCTGAAATCGAATGGTGCTTTGAGTACTGAGGAAAGGGAAGAAGAAATGAAGCAAATGGAAGTGTATCGGAGCCATTCTAAATTTATG
AAAAATAAGGTAGAACAACTGAAGGAGGAACTAAGTTCGAAAGAGGCTCAATGGGAGGAGCTGAAAAAGAAAGCGGCTGGTCTTCAGGCT
GAGATTGGCCAGGTGAAACAGGAGCTGTCCAGAAAGGACACAGAACTACTCGCCCTGCAGACAAAGCTAGAAACACTCACAAACCAGTTC
TCAGATAGTAAACAGCACATTGAAGTGTTGAAGGAGTCCTTGACTGCTAAGGAGCAGAGGGCTGCCATCCTGCAGACTGAGGTGGATGCT
CTCCGATTGCGTTTGGAAGAGAAGGAAACCATGTTGAATAAAAAGACAAAACAAATTCAGGATATGGCTGAAGAGAAGGGGACACAAGCT
GGAGAGATACATGACCTCAAGGACATGTTGGATGTGAAGGAGCGGAAGGTTAATGTTCTTCAGAAGAAGATTGAAAATCTTCAAGAGCAG
CTTAGAGACAAGGAAAAGCAGATGAGCAGCTTGAAAGAACGGGTCAAATCCTTGCAGGCTGACACCACCAACACTGACACTGCCTTGACA
ACTTTGGAGGAGGCCCTTGCAGAGAAAGAGCGGACAATTGAACGCTTAAAGGAGCAGAGGGACAGAGATGAGCGAGAGAAGCAAGAGGAA
ATTGATAACTACAAAAAAGATCTTAAAGACTTGAAGGAAAAAGTCAGCCTGTTGCAAGGCGACCTTTCAGAGAAAGAGGCTTCACTTTTG
GATCTGAAAGAGCATGCTTCTTCTCTGGCATCCTCAGGACTGAAAAAGGACTCACGGCTTAAGACACTAGAGATTGCTTTGGAGCAGAAG
AAGGAGGAGTGTCTGAAAATGGAATCACAATTGAAAAAGGCACATGAGGCAGCATTGGAAGCCAGAGCCAGTCCAGAGATGAGTGACCGA
ATACAGCACTTGGAGAGAGAGATCACCAGGTACAAAGATGAATCTAGCAAGGCCCAGGCAGAAGTTGATCGACTCTTAGAAATCTTGAAG
GAGGTGGAAAATGAGAAGAATGACAAAGATAAGAAGATAGCTGAGTTGGAAAGGCAAGTGAAAGACCAGAATAAGAAGGTAGCAAATCTG
AAGCACAAGGAACAGGTGGAAAAAAAGAAGAGTGCACAAATGTTAGAGGAGGCGCGACGACGGGAGGACAATCTCAACGACAGCTCTCAG
CAGCTACAGGACAGTCTCCGTAAGAAGGATGACAGGATTGAAGAGCTGGAAGAAGCACTAAGAGAAAGTGTACAGATAACTGCAGAGCGG
GAAATGGTGCTAGCACAAGAGGAATCAGCCAGGACCAATGCTGAAAAACAGGTGTGTGTCCACCGAAGCACCATCTACCCTGTGGGCCAG
TTCTGGGAGGAGGGCTGCGATGTGTGCACCTGCACCGACATGGAGGATGCCGTGATGGGCCTCCGCGTGGCCCAGTGCTCCCAGAAGCCC
TGTGAGGACAGCTGTCGGTCGGGCTTCACTTACGTTCTGCATGAAGGCGAGTGCTGTGGAAGGTGCCTGCCATCTGCCTGTGAGGTGGTG
ACTGGCTCACCGCGGGGGGACTCCCAGTCTTCCTGGAAGAGTGTCGGCTCCCAGTGGGCCTCCCCGGAGAACCCCTGCCTCATCAATGAG
TGTGTCCGAGTGAAGGAGGAGGTCTTTATACAACAAAGGAACGTCTCCTGCCCCCAGCTGGAGGTCCCTGTCTGCCCCTCGGGCTTTCAG
CTGAGCTGTAAGACCTCAGCGTGCTGCCCAAGCTGTCGCTGTGAGCGCATGGAGGCCTGCATGCTCAATGGCACTGTCATTGGGCCCGGG
AAGACTGTGATGATCGATGTGTGCACGACCTGCCGCTGCATGGTGCAGGTGGGGGTCATCTCTGGATTCAAGCTGGAGTGCAGGAAGACC
ACCTGCAACCCCTGCCCCCTGGGTTACAAGGAAGAAAATAACACAGGTGAATGTTGTGGGAGATGTTTGCCTACGGCTTGCACCATTCAG
CTAAGAGGAGGACAGATCATGACACTGAAGCGTGATGAGACGCTCCAGGATGGCTGTGATACTCACTTCTGCAAGGTCAATGAGAGAGGA
GAGTACTTCTGGGAGAAGAGGGTCACAGGCTGCCCACCCTTTGATGAACACAAGTGTCTGGCTGAGGGAGGTAAAATTATGAAAATTCCA
GGCACCTGCTGTGACACATGTGAGGAGCCTGAGTGCAACGACATCACTGCCAGGCTGCAGTATGTCAAGGTGGGAAGCTGTAAGTCTGAA
GTAGAGGTGGATATCCACTACTGCCAGGGCAAATGTGCCAGCAAAGCCATGTACTCCATTGACATCAACGATGTGCAGGACCAGTGCTCC
TGCTGCTCTCCGACACGGACGGAGCCCATGCAGGTGGCCCTGCACTGCACCAATGGCTCTGTTGTGTACCATGAGGTTCTCAATGCCATG
GAGTGCAAATGCTCCCCCAGGAAGTGCAGCAAGTGAGGCTGCTGCAGCTGCATGGGTGCCTGCTGCTGCCTGCCTTGGCCTGATGGCCAG

>27285_27285_1_ERC1-VWF_ERC1_chr12_1372331_ENST00000355446_VWF_chr12_6085426_ENST00000261405_length(amino acids)=1257AA_BP=872
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT
LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL
HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSK
EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK
KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIE
RLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKA
HEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQM
LEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVCVHRSTIYPVGQFWEEGCDVCTCTDM
EDAVMGLRVAQCSQKPCEDSCRSGFTYVLHEGECCGRCLPSACEVVTGSPRGDSQSSWKSVGSQWASPENPCLINECVRVKEEVFIQQRN
VSCPQLEVPVCPSGFQLSCKTSACCPSCRCERMEACMLNGTVIGPGKTVMIDVCTTCRCMVQVGVISGFKLECRKTTCNPCPLGYKEENN
TGECCGRCLPTACTIQLRGGQIMTLKRDETLQDGCDTHFCKVNERGEYFWEKRVTGCPPFDEHKCLAEGGKIMKIPGTCCDTCEEPECND

--------------------------------------------------------------
>27285_27285_2_ERC1-VWF_ERC1_chr12_1372331_ENST00000360905_VWF_chr12_6085426_ENST00000261405_length(transcript)=4096nt_BP=2800nt
AGCAGTAGCGGCAGCCCTGAGGACGATATGGTGTAAGATACTTCTTCAAGATTGGACAGCTGGGGACCTTCTTCTGATTAACCTTAAACC
AACTTGTAGCCATAGAGACACCTCACAAGGTTCCCATTTTTGTTGTTGTTGTTGTTGATTTTCTGCTCACACCTTTCCTGACCTTGCAAC
CATGTATGGAAGTGCCCGCTCTGTTGGGAAGGTGGAGCCGAGCAGCCAGAGCCCTGGGCGTTCACCCAGGCTTCCACGTTCCCCTCGCTT
GGGTCACCGTCGAACCAACAGTACGGGAGGGAGTTCGGGAAGCAGTGTTGGAGGTGGCAGTGGGAAAACCCTTTCAATGGAAAATATACA
ATCTTTAAATGCTGCCTATGCCACCTCTGGCCCTATGTATCTAAGTGACCATGAAAATGTGGGTTCAGAAACACCTAAAAGCACCATGAC
ACTTGGCCGTTCTGGGGGACGTCTGCCTTACGGTGTTCGGATGACTGCTATGGGTAGTAGCCCCAATATAGCTAGCAGTGGGGTTGCTAG
TGACACCATAGCATTTGGAGAGCATCACCTCCCTCCTGTGAGTATGGCATCCACTGTACCTCACTCCCTTCGTCAGGCGAGAGATAACAC
AATCATGGATCTGCAGACACAGCTGAAGGAAGTATTAAGAGAAAATGATCTCTTGCGGAAGGATGTGGAAGTAAAGGAGAGCAAATTGAG
TTCTTCAATGAATAGCATCAAGACCTTCTGGAGCCCAGAGCTGAAGAAGGAACGAGCCCTGAGAAAAGATGAAGCTTCCAAAATCACCAT
TTGGAAGGAACAGTACAGAGTTGTACAGGAGGAAAACCAGCACATGCAGATGACAATCCAGGCTCTCCAGGATGAATTGCGGATCCAGAG
GGACCTGAATCAGCTGTTTCAGCAGGATAGTAGCAGCAGGACTGGCGAACCTTGTGTAGCAGAGCTGACAGAGGAGAACTTTCAGAGGCT
TCATGCTGAGCATGAGCGGCAGGCCAAAGAGCTGTTTCTTCTTCGAAAGACATTGGAGGAAATGGAGCTGCGTATTGAGACTCAAAAGCA
GACCCTAAATGCTCGGGATGAATCCATTAAGAAGCTTCTGGAAATGTTGCAGAGCAAAGGACTTTCTGCCAAGGCTACCGAGGAAGACCA
TGAGAGAACAAGACGACTGGCAGAGGCAGAGATGCACGTTCATCACCTAGAAAGCCTTTTGGAGCAGAAGGAAAAAGAGAACAGTATGTT
GAGAGAGGAGATGCATCGAAGGTTTGAGAATGCTCCTGATTCTGCCAAAACAAAAGCTCTGCAAACTGTTATTGAGATGAAGGATTCAAA
AATTTCCTCTATGGAGCGTGGGCTTCGAGACCTGGAAGAGGAAATTCAGATGCTGAAATCGAATGGTGCTTTGAGTACTGAGGAAAGGGA
AGAAGAAATGAAGCAAATGGAAGTGTATCGGAGCCATTCTAAATTTATGAAAAATAAGGTAGAACAACTGAAGGAGGAACTAAGTTCGAA
AGAGGCTCAATGGGAGGAGCTGAAAAAGAAAGCGGCTGGTCTTCAGGCTGAGATTGGCCAGGTGAAACAGGAGCTGTCCAGAAAGGACAC
AGAACTACTCGCCCTGCAGACAAAGCTAGAAACACTCACAAACCAGTTCTCAGATAGTAAACAGCACATTGAAGTGTTGAAGGAGTCCTT
GACTGCTAAGGAGCAGAGGGCTGCCATCCTGCAGACTGAGGTGGATGCTCTCCGATTGCGTTTGGAAGAGAAGGAAACCATGTTGAATAA
AAAGACAAAACAAATTCAGGATATGGCTGAAGAGAAGGGGACACAAGCTGGAGAGATACATGACCTCAAGGACATGTTGGATGTGAAGGA
GCGGAAGGTTAATGTTCTTCAGAAGAAGATTGAAAATCTTCAAGAGCAGCTTAGAGACAAGGAAAAGCAGATGAGCAGCTTGAAAGAACG
GGTCAAATCCTTGCAGGCTGACACCACCAACACTGACACTGCCTTGACAACTTTGGAGGAGGCCCTTGCAGAGAAAGAGCGGACAATTGA
ACGCTTAAAGGAGCAGAGGGACAGAGATGAGCGAGAGAAGCAAGAGGAAATTGATAACTACAAAAAAGATCTTAAAGACTTGAAGGAAAA
AGTCAGCCTGTTGCAAGGCGACCTTTCAGAGAAAGAGGCTTCACTTTTGGATCTGAAAGAGCATGCTTCTTCTCTGGCATCCTCAGGACT
GAAAAAGGACTCACGGCTTAAGACACTAGAGATTGCTTTGGAGCAGAAGAAGGAGGAGTGTCTGAAAATGGAATCACAATTGAAAAAGGC
ACATGAGGCAGCATTGGAAGCCAGAGCCAGTCCAGAGATGAGTGACCGAATACAGCACTTGGAGAGAGAGATCACCAGGTACAAAGATGA
ATCTAGCAAGGCCCAGGCAGAAGTTGATCGACTCTTAGAAATCTTGAAGGAGGTGGAAAATGAGAAGAATGACAAAGATAAGAAGATAGC
TGAGTTGGAAAGGCAAGTGAAAGACCAGAATAAGAAGGTAGCAAATCTGAAGCACAAGGAACAGGTGGAAAAAAAGAAGAGTGCACAAAT
GTTAGAGGAGGCGCGACGACGGGAGGACAATCTCAACGACAGCTCTCAGCAGCTACAGGACAGTCTCCGTAAGAAGGATGACAGGATTGA
AGAGCTGGAAGAAGCACTAAGAGAAAGTGTACAGATAACTGCAGAGCGGGAAATGGTGCTAGCACAAGAGGAATCAGCCAGGACCAATGC
TGAAAAACAGGTGTGTGTCCACCGAAGCACCATCTACCCTGTGGGCCAGTTCTGGGAGGAGGGCTGCGATGTGTGCACCTGCACCGACAT
GGAGGATGCCGTGATGGGCCTCCGCGTGGCCCAGTGCTCCCAGAAGCCCTGTGAGGACAGCTGTCGGTCGGGCTTCACTTACGTTCTGCA
TGAAGGCGAGTGCTGTGGAAGGTGCCTGCCATCTGCCTGTGAGGTGGTGACTGGCTCACCGCGGGGGGACTCCCAGTCTTCCTGGAAGAG
TGTCGGCTCCCAGTGGGCCTCCCCGGAGAACCCCTGCCTCATCAATGAGTGTGTCCGAGTGAAGGAGGAGGTCTTTATACAACAAAGGAA
CGTCTCCTGCCCCCAGCTGGAGGTCCCTGTCTGCCCCTCGGGCTTTCAGCTGAGCTGTAAGACCTCAGCGTGCTGCCCAAGCTGTCGCTG
TGAGCGCATGGAGGCCTGCATGCTCAATGGCACTGTCATTGGGCCCGGGAAGACTGTGATGATCGATGTGTGCACGACCTGCCGCTGCAT
GGTGCAGGTGGGGGTCATCTCTGGATTCAAGCTGGAGTGCAGGAAGACCACCTGCAACCCCTGCCCCCTGGGTTACAAGGAAGAAAATAA
CACAGGTGAATGTTGTGGGAGATGTTTGCCTACGGCTTGCACCATTCAGCTAAGAGGAGGACAGATCATGACACTGAAGCGTGATGAGAC
GCTCCAGGATGGCTGTGATACTCACTTCTGCAAGGTCAATGAGAGAGGAGAGTACTTCTGGGAGAAGAGGGTCACAGGCTGCCCACCCTT
TGATGAACACAAGTGTCTGGCTGAGGGAGGTAAAATTATGAAAATTCCAGGCACCTGCTGTGACACATGTGAGGAGCCTGAGTGCAACGA
CATCACTGCCAGGCTGCAGTATGTCAAGGTGGGAAGCTGTAAGTCTGAAGTAGAGGTGGATATCCACTACTGCCAGGGCAAATGTGCCAG
CAAAGCCATGTACTCCATTGACATCAACGATGTGCAGGACCAGTGCTCCTGCTGCTCTCCGACACGGACGGAGCCCATGCAGGTGGCCCT
GCACTGCACCAATGGCTCTGTTGTGTACCATGAGGTTCTCAATGCCATGGAGTGCAAATGCTCCCCCAGGAAGTGCAGCAAGTGAGGCTG
CTGCAGCTGCATGGGTGCCTGCTGCTGCCTGCCTTGGCCTGATGGCCAGGCCAGAGTGCTGCCAGTCCTCTGCATGTTCTGCTCTTGTGC

>27285_27285_2_ERC1-VWF_ERC1_chr12_1372331_ENST00000360905_VWF_chr12_6085426_ENST00000261405_length(amino acids)=1257AA_BP=872
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT
LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL
HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSK
EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK
KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIE
RLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKA
HEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQM
LEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVCVHRSTIYPVGQFWEEGCDVCTCTDM
EDAVMGLRVAQCSQKPCEDSCRSGFTYVLHEGECCGRCLPSACEVVTGSPRGDSQSSWKSVGSQWASPENPCLINECVRVKEEVFIQQRN
VSCPQLEVPVCPSGFQLSCKTSACCPSCRCERMEACMLNGTVIGPGKTVMIDVCTTCRCMVQVGVISGFKLECRKTTCNPCPLGYKEENN
TGECCGRCLPTACTIQLRGGQIMTLKRDETLQDGCDTHFCKVNERGEYFWEKRVTGCPPFDEHKCLAEGGKIMKIPGTCCDTCEEPECND

--------------------------------------------------------------
>27285_27285_3_ERC1-VWF_ERC1_chr12_1372331_ENST00000397203_VWF_chr12_6085426_ENST00000261405_length(transcript)=4321nt_BP=3025nt
GTGCTGTGGCGGCGGCGGCGGCGGTAGTGGCGGCGGCGGCGGTGCCTGGGCGGCAGCAGCAGCAGTAGCGGCAGCCCTGAGGACGGTGAG
ACGGCCGCGGCGGCGGCGACAGCGCGGAAGTCGCGCGGGACCCAGAGCTTCCCCCCTGTCGCTAGTGCTGAGGCTTTCGCCTTTCCTACC
CAGCTTCTTGCTCACGGCCCGGGCTGGGCTGGGCAGGGCAACGCGCCCCCGGGGAGGGGCGGAGCTGTAGATATGGTGTAAGATACTTCT
TCAAGATTGGACAGCTGGGGACCTTCTTCTGATTAACCTTAAACCAACTTGTAGCCATAGAGACACCTCACAAGGTTCCCATTTTTGTTG
TTGTTGTTGTTGATTTTCTGCTCACACCTTTCCTGACCTTGCAACCATGTATGGAAGTGCCCGCTCTGTTGGGAAGGTGGAGCCGAGCAG
CCAGAGCCCTGGGCGTTCACCCAGGCTTCCACGTTCCCCTCGCTTGGGTCACCGTCGAACCAACAGTACGGGAGGGAGTTCGGGAAGCAG
TGTTGGAGGTGGCAGTGGGAAAACCCTTTCAATGGAAAATATACAATCTTTAAATGCTGCCTATGCCACCTCTGGCCCTATGTATCTAAG
TGACCATGAAAATGTGGGTTCAGAAACACCTAAAAGCACCATGACACTTGGCCGTTCTGGGGGACGTCTGCCTTACGGTGTTCGGATGAC
TGCTATGGGTAGTAGCCCCAATATAGCTAGCAGTGGGGTTGCTAGTGACACCATAGCATTTGGAGAGCATCACCTCCCTCCTGTGAGTAT
GGCATCCACTGTACCTCACTCCCTTCGTCAGGCGAGAGATAACACAATCATGGATCTGCAGACACAGCTGAAGGAAGTATTAAGAGAAAA
TGATCTCTTGCGGAAGGATGTGGAAGTAAAGGAGAGCAAATTGAGTTCTTCAATGAATAGCATCAAGACCTTCTGGAGCCCAGAGCTGAA
GAAGGAACGAGCCCTGAGAAAAGATGAAGCTTCCAAAATCACCATTTGGAAGGAACAGTACAGAGTTGTACAGGAGGAAAACCAGCACAT
GCAGATGACAATCCAGGCTCTCCAGGATGAATTGCGGATCCAGAGGGACCTGAATCAGCTGTTTCAGCAGGATAGTAGCAGCAGGACTGG
CGAACCTTGTGTAGCAGAGCTGACAGAGGAGAACTTTCAGAGGCTTCATGCTGAGCATGAGCGGCAGGCCAAAGAGCTGTTTCTTCTTCG
AAAGACATTGGAGGAAATGGAGCTGCGTATTGAGACTCAAAAGCAGACCCTAAATGCTCGGGATGAATCCATTAAGAAGCTTCTGGAAAT
GTTGCAGAGCAAAGGACTTTCTGCCAAGGCTACCGAGGAAGACCATGAGAGAACAAGACGACTGGCAGAGGCAGAGATGCACGTTCATCA
CCTAGAAAGCCTTTTGGAGCAGAAGGAAAAAGAGAACAGTATGTTGAGAGAGGAGATGCATCGAAGGTTTGAGAATGCTCCTGATTCTGC
CAAAACAAAAGCTCTGCAAACTGTTATTGAGATGAAGGATTCAAAAATTTCCTCTATGGAGCGTGGGCTTCGAGACCTGGAAGAGGAAAT
TCAGATGCTGAAATCGAATGGTGCTTTGAGTACTGAGGAAAGGGAAGAAGAAATGAAGCAAATGGAAGTGTATCGGAGCCATTCTAAATT
TATGAAAAATAAGGTAGAACAACTGAAGGAGGAACTAAGTTCGAAAGAGGCTCAATGGGAGGAGCTGAAAAAGAAAGCGGCTGGTCTTCA
GGCTGAGATTGGCCAGGTGAAACAGGAGCTGTCCAGAAAGGACACAGAACTACTCGCCCTGCAGACAAAGCTAGAAACACTCACAAACCA
GTTCTCAGATAGTAAACAGCACATTGAAGTGTTGAAGGAGTCCTTGACTGCTAAGGAGCAGAGGGCTGCCATCCTGCAGACTGAGGTGGA
TGCTCTCCGATTGCGTTTGGAAGAGAAGGAAACCATGTTGAATAAAAAGACAAAACAAATTCAGGATATGGCTGAAGAGAAGGGGACACA
AGCTGGAGAGATACATGACCTCAAGGACATGTTGGATGTGAAGGAGCGGAAGGTTAATGTTCTTCAGAAGAAGATTGAAAATCTTCAAGA
GCAGCTTAGAGACAAGGAAAAGCAGATGAGCAGCTTGAAAGAACGGGTCAAATCCTTGCAGGCTGACACCACCAACACTGACACTGCCTT
GACAACTTTGGAGGAGGCCCTTGCAGAGAAAGAGCGGACAATTGAACGCTTAAAGGAGCAGAGGGACAGAGATGAGCGAGAGAAGCAAGA
GGAAATTGATAACTACAAAAAAGATCTTAAAGACTTGAAGGAAAAAGTCAGCCTGTTGCAAGGCGACCTTTCAGAGAAAGAGGCTTCACT
TTTGGATCTGAAAGAGCATGCTTCTTCTCTGGCATCCTCAGGACTGAAAAAGGACTCACGGCTTAAGACACTAGAGATTGCTTTGGAGCA
GAAGAAGGAGGAGTGTCTGAAAATGGAATCACAATTGAAAAAGGCACATGAGGCAGCATTGGAAGCCAGAGCCAGTCCAGAGATGAGTGA
CCGAATACAGCACTTGGAGAGAGAGATCACCAGGTACAAAGATGAATCTAGCAAGGCCCAGGCAGAAGTTGATCGACTCTTAGAAATCTT
GAAGGAGGTGGAAAATGAGAAGAATGACAAAGATAAGAAGATAGCTGAGTTGGAAAGGCAAGTGAAAGACCAGAATAAGAAGGTAGCAAA
TCTGAAGCACAAGGAACAGGTGGAAAAAAAGAAGAGTGCACAAATGTTAGAGGAGGCGCGACGACGGGAGGACAATCTCAACGACAGCTC
TCAGCAGCTACAGGACAGTCTCCGTAAGAAGGATGACAGGATTGAAGAGCTGGAAGAAGCACTAAGAGAAAGTGTACAGATAACTGCAGA
GCGGGAAATGGTGCTAGCACAAGAGGAATCAGCCAGGACCAATGCTGAAAAACAGGTGTGTGTCCACCGAAGCACCATCTACCCTGTGGG
CCAGTTCTGGGAGGAGGGCTGCGATGTGTGCACCTGCACCGACATGGAGGATGCCGTGATGGGCCTCCGCGTGGCCCAGTGCTCCCAGAA
GCCCTGTGAGGACAGCTGTCGGTCGGGCTTCACTTACGTTCTGCATGAAGGCGAGTGCTGTGGAAGGTGCCTGCCATCTGCCTGTGAGGT
GGTGACTGGCTCACCGCGGGGGGACTCCCAGTCTTCCTGGAAGAGTGTCGGCTCCCAGTGGGCCTCCCCGGAGAACCCCTGCCTCATCAA
TGAGTGTGTCCGAGTGAAGGAGGAGGTCTTTATACAACAAAGGAACGTCTCCTGCCCCCAGCTGGAGGTCCCTGTCTGCCCCTCGGGCTT
TCAGCTGAGCTGTAAGACCTCAGCGTGCTGCCCAAGCTGTCGCTGTGAGCGCATGGAGGCCTGCATGCTCAATGGCACTGTCATTGGGCC
CGGGAAGACTGTGATGATCGATGTGTGCACGACCTGCCGCTGCATGGTGCAGGTGGGGGTCATCTCTGGATTCAAGCTGGAGTGCAGGAA
GACCACCTGCAACCCCTGCCCCCTGGGTTACAAGGAAGAAAATAACACAGGTGAATGTTGTGGGAGATGTTTGCCTACGGCTTGCACCAT
TCAGCTAAGAGGAGGACAGATCATGACACTGAAGCGTGATGAGACGCTCCAGGATGGCTGTGATACTCACTTCTGCAAGGTCAATGAGAG
AGGAGAGTACTTCTGGGAGAAGAGGGTCACAGGCTGCCCACCCTTTGATGAACACAAGTGTCTGGCTGAGGGAGGTAAAATTATGAAAAT
TCCAGGCACCTGCTGTGACACATGTGAGGAGCCTGAGTGCAACGACATCACTGCCAGGCTGCAGTATGTCAAGGTGGGAAGCTGTAAGTC
TGAAGTAGAGGTGGATATCCACTACTGCCAGGGCAAATGTGCCAGCAAAGCCATGTACTCCATTGACATCAACGATGTGCAGGACCAGTG
CTCCTGCTGCTCTCCGACACGGACGGAGCCCATGCAGGTGGCCCTGCACTGCACCAATGGCTCTGTTGTGTACCATGAGGTTCTCAATGC
CATGGAGTGCAAATGCTCCCCCAGGAAGTGCAGCAAGTGAGGCTGCTGCAGCTGCATGGGTGCCTGCTGCTGCCTGCCTTGGCCTGATGG
CCAGGCCAGAGTGCTGCCAGTCCTCTGCATGTTCTGCTCTTGTGCCCTTCTGAGCCCACAATAAAGGCTGAGCTCTTATCTTGCAAAAGG

>27285_27285_3_ERC1-VWF_ERC1_chr12_1372331_ENST00000397203_VWF_chr12_6085426_ENST00000261405_length(amino acids)=1257AA_BP=872
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT
LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL
HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSK
EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK
KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIE
RLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKA
HEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQM
LEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVCVHRSTIYPVGQFWEEGCDVCTCTDM
EDAVMGLRVAQCSQKPCEDSCRSGFTYVLHEGECCGRCLPSACEVVTGSPRGDSQSSWKSVGSQWASPENPCLINECVRVKEEVFIQQRN
VSCPQLEVPVCPSGFQLSCKTSACCPSCRCERMEACMLNGTVIGPGKTVMIDVCTTCRCMVQVGVISGFKLECRKTTCNPCPLGYKEENN
TGECCGRCLPTACTIQLRGGQIMTLKRDETLQDGCDTHFCKVNERGEYFWEKRVTGCPPFDEHKCLAEGGKIMKIPGTCCDTCEEPECND

--------------------------------------------------------------
>27285_27285_4_ERC1-VWF_ERC1_chr12_1372331_ENST00000543086_VWF_chr12_6085426_ENST00000261405_length(transcript)=4102nt_BP=2806nt
GGGCGCGGTGACGTCGCGGGCGCCTGGGCCGTGCTGTGGCGGCGGCGGCGGCGGTAGTGGCGGCGGCGGCGGTGCCTGGGCGGCAGCAGC
AGCAGTAGCGGCAGCCCTGAGGACGATATGGTGTAAGATACTTCTTCAAGATTGGACAGCTGGGGACCTTCTTCTGATTAACCTTAAACC
AACTTGTAGCCATAGAGACACCTCACAAGGTTCCCATTTTTGTTGTTGTTGTTGTTGATTTTCTGCTCACACCTTTCCTGACCTTGCAAC
CATGTATGGAAGTGCCCGCTCTGTTGGGAAGGTGGAGCCGAGCAGCCAGAGCCCTGGGCGTTCACCCAGGCTTCCACGTTCCCCTCGCTT
GGGTCACCGTCGAACCAACAGTACGGGAGGGAGTTCGGGAAGCAGTGTTGGAGGTGGCAGTGGGAAAACCCTTTCAATGGAAAATATACA
ATCTTTAAATGCTGCCTATGCCACCTCTGGCCCTATGTATCTAAGTGACCATGAAAATGTGGGTTCAGAAACACCTAAAAGCACCATGAC
ACTTGGCCGTTCTGGGGGACGTCTGCCTTACGGTGTTCGGATGACTGCTATGGGTAGTAGCCCCAATATAGCTAGCAGTGGGGTTGCTAG
TGACACCATAGCATTTGGAGAGCATCACCTCCCTCCTGTGAGTATGGCATCCACTGTACCTCACTCCCTTCGTCAGGCGAGAGATAACAC
AATCATGGATCTGCAGACACAGCTGAAGGAAGTATTAAGAGAAAATGATCTCTTGCGGAAGGATGTGGAAGTAAAGGAGAGCAAATTGAG
TTCTTCAATGAATAGCATCAAGACCTTCTGGAGCCCAGAGCTGAAGAAGGAACGAGCCCTGAGAAAAGATGAAGCTTCCAAAATCACCAT
TTGGAAGGAACAGTACAGAGTTGTACAGGAGGAAAACCAGCACATGCAGATGACAATCCAGGCTCTCCAGGATGAATTGCGGATCCAGAG
GGACCTGAATCAGCTGTTTCAGCAGGATAGTAGCAGCAGGACTGGCGAACCTTGTGTAGCAGAGCTGACAGAGGAGAACTTTCAGAGGCT
TCATGCTGAGCATGAGCGGCAGGCCAAAGAGCTGTTTCTTCTTCGAAAGACATTGGAGGAAATGGAGCTGCGTATTGAGACTCAAAAGCA
GACCCTAAATGCTCGGGATGAATCCATTAAGAAGCTTCTGGAAATGTTGCAGAGCAAAGGACTTTCTGCCAAGGCTACCGAGGAAGACCA
TGAGAGAACAAGACGACTGGCAGAGGCAGAGATGCACGTTCATCACCTAGAAAGCCTTTTGGAGCAGAAGGAAAAAGAGAACAGTATGTT
GAGAGAGGAGATGCATCGAAGGTTTGAGAATGCTCCTGATTCTGCCAAAACAAAAGCTCTGCAAACTGTTATTGAGATGAAGGATTCAAA
AATTTCCTCTATGGAGCGTGGGCTTCGAGACCTGGAAGAGGAAATTCAGATGCTGAAATCGAATGGTGCTTTGAGTACTGAGGAAAGGGA
AGAAGAAATGAAGCAAATGGAAGTGTATCGGAGCCATTCTAAATTTATGAAAAATAAGATTGGCCAGGTGAAACAGGAGCTGTCCAGAAA
GGACACAGAACTACTCGCCCTGCAGACAAAGCTAGAAACACTCACAAACCAGTTCTCAGATAGTAAACAGCACATTGAAGTGTTGAAGGA
GTCCTTGACTGCTAAGGAGCAGAGGGCTGCCATCCTGCAGACTGAGGTGGATGCTCTCCGATTGCGTTTGGAAGAGAAGGAAACCATGTT
GAATAAAAAGACAAAACAAATTCAGGATATGGCTGAAGAGAAGGGGACACAAGCTGGAGAGATACATGACCTCAAGGACATGTTGGATGT
GAAGGAGCGGAAGGTTAATGTTCTTCAGAAGAAGATTGAAAATCTTCAAGAGCAGCTTAGAGACAAGGAAAAGCAGATGAGCAGCTTGAA
AGAACGGGTCAAATCCTTGCAGGCTGACACCACCAACACTGACACTGCCTTGACAACTTTGGAGGAGGCCCTTGCAGAGAAAGAGCGGAC
AATTGAACGCTTAAAGGAGCAGAGGGACAGAGATGAGCGAGAGAAGCAAGAGGAAATTGATAACTACAAAAAAGATCTTAAAGACTTGAA
GGAAAAAGTCAGCCTGTTGCAAGGCGACCTTTCAGAGAAAGAGGCTTCACTTTTGGATCTGAAAGAGCATGCTTCTTCTCTGGCATCCTC
AGGACTGAAAAAGGACTCACGGCTTAAGACACTAGAGATTGCTTTGGAGCAGAAGAAGGAGGAGTGTCTGAAAATGGAATCACAATTGAA
AAAGGCACATGAGGCAGCATTGGAAGCCAGAGCCAGTCCAGAGATGAGTGACCGAATACAGCACTTGGAGAGAGAGATCACCAGGTACAA
AGATGAATCTAGCAAGGCCCAGGCAGAAGTTGATCGACTCTTAGAAATCTTGAAGGAGGTGGAAAATGAGAAGAATGACAAAGATAAGAA
GATAGCTGAGTTGGAAAGGCAAGTGAAAGACCAGAATAAGAAGGTAGCAAATCTGAAGCACAAGGAACAGGTGGAAAAAAAGAAGAGTGC
ACAAATGTTAGAGGAGGCGCGACGACGGGAGGACAATCTCAACGACAGCTCTCAGCAGCTACAGGACAGTCTCCGTAAGAAGGATGACAG
GATTGAAGAGCTGGAAGAAGCACTAAGAGAAAGTGTACAGATAACTGCAGAGCGGGAAATGGTGCTAGCACAAGAGGAATCAGCCAGGAC
CAATGCTGAAAAACAGGTGTGTGTCCACCGAAGCACCATCTACCCTGTGGGCCAGTTCTGGGAGGAGGGCTGCGATGTGTGCACCTGCAC
CGACATGGAGGATGCCGTGATGGGCCTCCGCGTGGCCCAGTGCTCCCAGAAGCCCTGTGAGGACAGCTGTCGGTCGGGCTTCACTTACGT
TCTGCATGAAGGCGAGTGCTGTGGAAGGTGCCTGCCATCTGCCTGTGAGGTGGTGACTGGCTCACCGCGGGGGGACTCCCAGTCTTCCTG
GAAGAGTGTCGGCTCCCAGTGGGCCTCCCCGGAGAACCCCTGCCTCATCAATGAGTGTGTCCGAGTGAAGGAGGAGGTCTTTATACAACA
AAGGAACGTCTCCTGCCCCCAGCTGGAGGTCCCTGTCTGCCCCTCGGGCTTTCAGCTGAGCTGTAAGACCTCAGCGTGCTGCCCAAGCTG
TCGCTGTGAGCGCATGGAGGCCTGCATGCTCAATGGCACTGTCATTGGGCCCGGGAAGACTGTGATGATCGATGTGTGCACGACCTGCCG
CTGCATGGTGCAGGTGGGGGTCATCTCTGGATTCAAGCTGGAGTGCAGGAAGACCACCTGCAACCCCTGCCCCCTGGGTTACAAGGAAGA
AAATAACACAGGTGAATGTTGTGGGAGATGTTTGCCTACGGCTTGCACCATTCAGCTAAGAGGAGGACAGATCATGACACTGAAGCGTGA
TGAGACGCTCCAGGATGGCTGTGATACTCACTTCTGCAAGGTCAATGAGAGAGGAGAGTACTTCTGGGAGAAGAGGGTCACAGGCTGCCC
ACCCTTTGATGAACACAAGTGTCTGGCTGAGGGAGGTAAAATTATGAAAATTCCAGGCACCTGCTGTGACACATGTGAGGAGCCTGAGTG
CAACGACATCACTGCCAGGCTGCAGTATGTCAAGGTGGGAAGCTGTAAGTCTGAAGTAGAGGTGGATATCCACTACTGCCAGGGCAAATG
TGCCAGCAAAGCCATGTACTCCATTGACATCAACGATGTGCAGGACCAGTGCTCCTGCTGCTCTCCGACACGGACGGAGCCCATGCAGGT
GGCCCTGCACTGCACCAATGGCTCTGTTGTGTACCATGAGGTTCTCAATGCCATGGAGTGCAAATGCTCCCCCAGGAAGTGCAGCAAGTG
AGGCTGCTGCAGCTGCATGGGTGCCTGCTGCTGCCTGCCTTGGCCTGATGGCCAGGCCAGAGTGCTGCCAGTCCTCTGCATGTTCTGCTC

>27285_27285_4_ERC1-VWF_ERC1_chr12_1372331_ENST00000543086_VWF_chr12_6085426_ENST00000261405_length(amino acids)=1229AA_BP=844
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT
LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL
HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRK
DTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDV
KERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLK
EKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYK
DESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDR
IEELEEALRESVQITAEREMVLAQEESARTNAEKQVCVHRSTIYPVGQFWEEGCDVCTCTDMEDAVMGLRVAQCSQKPCEDSCRSGFTYV
LHEGECCGRCLPSACEVVTGSPRGDSQSSWKSVGSQWASPENPCLINECVRVKEEVFIQQRNVSCPQLEVPVCPSGFQLSCKTSACCPSC
RCERMEACMLNGTVIGPGKTVMIDVCTTCRCMVQVGVISGFKLECRKTTCNPCPLGYKEENNTGECCGRCLPTACTIQLRGGQIMTLKRD
ETLQDGCDTHFCKVNERGEYFWEKRVTGCPPFDEHKCLAEGGKIMKIPGTCCDTCEEPECNDITARLQYVKVGSCKSEVEVDIHYCQGKC

--------------------------------------------------------------
>27285_27285_5_ERC1-VWF_ERC1_chr12_1372331_ENST00000546231_VWF_chr12_6085426_ENST00000261405_length(transcript)=4455nt_BP=3159nt
GGGCCGTGCTGTGGCGGCGGCGGCGGCGGTAGTGGCGGCGGCGGCGGTGCCTGGGCGGCAGCAGCAGCAGTAGCGGCAGCCCTGAGGACG
GTGAGACGGCCGCGGCGGCGGCGACAGCGCGGAAGTCGCGCGGGACCCAGAGCTTCCCCCCTGTCGCTAGTGCTGAGGCTTTCGCCTTTC
CTACCCAGCTTCTTGCTCACGGCCCGGGCTGGGCTGGGCAGGGCAACGCGCCCCCGGGGAGGGGCGGAGCTGTAGGTTGGTCTTGAACTC
CTGGCCTCAAGCGATCTTCCTACCTTGGCCTCCCAGAGCGCTGGGATTATAGGCATGAGCCATTGCACTTGGCACTTTTTTTGTTTGTTT
TCCAGTTGCATGATATGGTGTAAGATACTTCTTCAAGATTGGACAGCTGGGGACCTTCTTCTGATTAACCTTAAACCAACTTGTAGCCAT
AGAGACACCTCACAAGGTTCCCATTTTTGTTGTTGTTGTTGTTGATTTTCTGCTCACACCTTTCCTGACCTTGCAACCATGTATGGAAGT
GCCCGCTCTGTTGGGAAGGTGGAGCCGAGCAGCCAGAGCCCTGGGCGTTCACCCAGGCTTCCACGTTCCCCTCGCTTGGGTCACCGTCGA
ACCAACAGTACGGGAGGGAGTTCGGGAAGCAGTGTTGGAGGTGGCAGTGGGAAAACCCTTTCAATGGAAAATATACAATCTTTAAATGCT
GCCTATGCCACCTCTGGCCCTATGTATCTAAGTGACCATGAAAATGTGGGTTCAGAAACACCTAAAAGCACCATGACACTTGGCCGTTCT
GGGGGACGTCTGCCTTACGGTGTTCGGATGACTGCTATGGGTAGTAGCCCCAATATAGCTAGCAGTGGGGTTGCTAGTGACACCATAGCA
TTTGGAGAGCATCACCTCCCTCCTGTGAGTATGGCATCCACTGTACCTCACTCCCTTCGTCAGGCGAGAGATAACACAATCATGGATCTG
CAGACACAGCTGAAGGAAGTATTAAGAGAAAATGATCTCTTGCGGAAGGATGTGGAAGTAAAGGAGAGCAAATTGAGTTCTTCAATGAAT
AGCATCAAGACCTTCTGGAGCCCAGAGCTGAAGAAGGAACGAGCCCTGAGAAAAGATGAAGCTTCCAAAATCACCATTTGGAAGGAACAG
TACAGAGTTGTACAGGAGGAAAACCAGCACATGCAGATGACAATCCAGGCTCTCCAGGATGAATTGCGGATCCAGAGGGACCTGAATCAG
CTGTTTCAGCAGGATAGTAGCAGCAGGACTGGCGAACCTTGTGTAGCAGAGCTGACAGAGGAGAACTTTCAGAGGCTTCATGCTGAGCAT
GAGCGGCAGGCCAAAGAGCTGTTTCTTCTTCGAAAGACATTGGAGGAAATGGAGCTGCGTATTGAGACTCAAAAGCAGACCCTAAATGCT
CGGGATGAATCCATTAAGAAGCTTCTGGAAATGTTGCAGAGCAAAGGACTTTCTGCCAAGGCTACCGAGGAAGACCATGAGAGAACAAGA
CGACTGGCAGAGGCAGAGATGCACGTTCATCACCTAGAAAGCCTTTTGGAGCAGAAGGAAAAAGAGAACAGTATGTTGAGAGAGGAGATG
CATCGAAGGTTTGAGAATGCTCCTGATTCTGCCAAAACAAAAGCTCTGCAAACTGTTATTGAGATGAAGGATTCAAAAATTTCCTCTATG
GAGCGTGGGCTTCGAGACCTGGAAGAGGAAATTCAGATGCTGAAATCGAATGGTGCTTTGAGTACTGAGGAAAGGGAAGAAGAAATGAAG
CAAATGGAAGTGTATCGGAGCCATTCTAAATTTATGAAAAATAAGGTAGAACAACTGAAGGAGGAACTAAGTTCGAAAGAGGCTCAATGG
GAGGAGCTGAAAAAGAAAGCGGCTGGTCTTCAGGCTGAGATTGGCCAGGTGAAACAGGAGCTGTCCAGAAAGGACACAGAACTACTCGCC
CTGCAGACAAAGCTAGAAACACTCACAAACCAGTTCTCAGATAGTAAACAGCACATTGAAGTGTTGAAGGAGTCCTTGACTGCTAAGGAG
CAGAGGGCTGCCATCCTGCAGACTGAGGTGGATGCTCTCCGATTGCGTTTGGAAGAGAAGGAAACCATGTTGAATAAAAAGACAAAACAA
ATTCAGGATATGGCTGAAGAGAAGGGGACACAAGCTGGAGAGATACATGACCTCAAGGACATGTTGGATGTGAAGGAGCGGAAGGTTAAT
GTTCTTCAGAAGAAGATTGAAAATCTTCAAGAGCAGCTTAGAGACAAGGAAAAGCAGATGAGCAGCTTGAAAGAACGGGTCAAATCCTTG
CAGGCTGACACCACCAACACTGACACTGCCTTGACAACTTTGGAGGAGGCCCTTGCAGAGAAAGAGCGGACAATTGAACGCTTAAAGGAG
CAGAGGGACAGAGATGAGCGAGAGAAGCAAGAGGAAATTGATAACTACAAAAAAGATCTTAAAGACTTGAAGGAAAAAGTCAGCCTGTTG
CAAGGCGACCTTTCAGAGAAAGAGGCTTCACTTTTGGATCTGAAAGAGCATGCTTCTTCTCTGGCATCCTCAGGACTGAAAAAGGACTCA
CGGCTTAAGACACTAGAGATTGCTTTGGAGCAGAAGAAGGAGGAGTGTCTGAAAATGGAATCACAATTGAAAAAGGCACATGAGGCAGCA
TTGGAAGCCAGAGCCAGTCCAGAGATGAGTGACCGAATACAGCACTTGGAGAGAGAGATCACCAGGTACAAAGATGAATCTAGCAAGGCC
CAGGCAGAAGTTGATCGACTCTTAGAAATCTTGAAGGAGGTGGAAAATGAGAAGAATGACAAAGATAAGAAGATAGCTGAGTTGGAAAGT
CTCACCTCAAGGCAAGTGAAAGACCAGAATAAGAAGGTAGCAAATCTGAAGCACAAGGAACAGGTGGAAAAAAAGAAGAGTGCACAAATG
TTAGAGGAGGCGCGACGACGGGAGGACAATCTCAACGACAGCTCTCAGCAGCTACAGGACAGTCTCCGTAAGAAGGATGACAGGATTGAA
GAGCTGGAAGAAGCACTAAGAGAAAGTGTACAGATAACTGCAGAGCGGGAAATGGTGCTAGCACAAGAGGAATCAGCCAGGACCAATGCT
GAAAAACAGGTGTGTGTCCACCGAAGCACCATCTACCCTGTGGGCCAGTTCTGGGAGGAGGGCTGCGATGTGTGCACCTGCACCGACATG
GAGGATGCCGTGATGGGCCTCCGCGTGGCCCAGTGCTCCCAGAAGCCCTGTGAGGACAGCTGTCGGTCGGGCTTCACTTACGTTCTGCAT
GAAGGCGAGTGCTGTGGAAGGTGCCTGCCATCTGCCTGTGAGGTGGTGACTGGCTCACCGCGGGGGGACTCCCAGTCTTCCTGGAAGAGT
GTCGGCTCCCAGTGGGCCTCCCCGGAGAACCCCTGCCTCATCAATGAGTGTGTCCGAGTGAAGGAGGAGGTCTTTATACAACAAAGGAAC
GTCTCCTGCCCCCAGCTGGAGGTCCCTGTCTGCCCCTCGGGCTTTCAGCTGAGCTGTAAGACCTCAGCGTGCTGCCCAAGCTGTCGCTGT
GAGCGCATGGAGGCCTGCATGCTCAATGGCACTGTCATTGGGCCCGGGAAGACTGTGATGATCGATGTGTGCACGACCTGCCGCTGCATG
GTGCAGGTGGGGGTCATCTCTGGATTCAAGCTGGAGTGCAGGAAGACCACCTGCAACCCCTGCCCCCTGGGTTACAAGGAAGAAAATAAC
ACAGGTGAATGTTGTGGGAGATGTTTGCCTACGGCTTGCACCATTCAGCTAAGAGGAGGACAGATCATGACACTGAAGCGTGATGAGACG
CTCCAGGATGGCTGTGATACTCACTTCTGCAAGGTCAATGAGAGAGGAGAGTACTTCTGGGAGAAGAGGGTCACAGGCTGCCCACCCTTT
GATGAACACAAGTGTCTGGCTGAGGGAGGTAAAATTATGAAAATTCCAGGCACCTGCTGTGACACATGTGAGGAGCCTGAGTGCAACGAC
ATCACTGCCAGGCTGCAGTATGTCAAGGTGGGAAGCTGTAAGTCTGAAGTAGAGGTGGATATCCACTACTGCCAGGGCAAATGTGCCAGC
AAAGCCATGTACTCCATTGACATCAACGATGTGCAGGACCAGTGCTCCTGCTGCTCTCCGACACGGACGGAGCCCATGCAGGTGGCCCTG
CACTGCACCAATGGCTCTGTTGTGTACCATGAGGTTCTCAATGCCATGGAGTGCAAATGCTCCCCCAGGAAGTGCAGCAAGTGAGGCTGC
TGCAGCTGCATGGGTGCCTGCTGCTGCCTGCCTTGGCCTGATGGCCAGGCCAGAGTGCTGCCAGTCCTCTGCATGTTCTGCTCTTGTGCC

>27285_27285_5_ERC1-VWF_ERC1_chr12_1372331_ENST00000546231_VWF_chr12_6085426_ENST00000261405_length(amino acids)=1261AA_BP=876
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT
LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL
HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSK
EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK
KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIE
RLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKA
HEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELESLTSRQVKDQNKKVANLKHKEQVEKKK
SAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVCVHRSTIYPVGQFWEEGCDVCT
CTDMEDAVMGLRVAQCSQKPCEDSCRSGFTYVLHEGECCGRCLPSACEVVTGSPRGDSQSSWKSVGSQWASPENPCLINECVRVKEEVFI
QQRNVSCPQLEVPVCPSGFQLSCKTSACCPSCRCERMEACMLNGTVIGPGKTVMIDVCTTCRCMVQVGVISGFKLECRKTTCNPCPLGYK
EENNTGECCGRCLPTACTIQLRGGQIMTLKRDETLQDGCDTHFCKVNERGEYFWEKRVTGCPPFDEHKCLAEGGKIMKIPGTCCDTCEEP
ECNDITARLQYVKVGSCKSEVEVDIHYCQGKCASKAMYSIDINDVQDQCSCCSPTRTEPMQVALHCTNGSVVYHEVLNAMECKCSPRKCS

--------------------------------------------------------------
>27285_27285_6_ERC1-VWF_ERC1_chr12_1372331_ENST00000589028_VWF_chr12_6085426_ENST00000261405_length(transcript)=4072nt_BP=2776nt
GATATGGTGTAAGATACTTCTTCAAGATTGGACAGCTGGGGACCTTCTTCTGATTAACCTTAAACCAACTTGTAGCCATAGAGACACCTC
ACAAGGTTCCCATTTTTGTTGTTGTTGTTGTTGATTTTCTGCTCACACCTTTCCTGACCTTGCAACCATGTATGGAAGTGCCCGCTCTGT
TGGGAAGGTGGAGCCGAGCAGCCAGAGCCCTGGGCGTTCACCCAGGCTTCCACGTTCCCCTCGCTTGGGTCACCGTCGAACCAACAGTAC
GGGAGGGAGTTCGGGAAGCAGTGTTGGAGGTGGCAGTGGGAAAACCCTTTCAATGGAAAATATACAATCTTTAAATGCTGCCTATGCCAC
CTCTGGCCCTATGTATCTAAGTGACCATGAAAATGTGGGTTCAGAAACACCTAAAAGCACCATGACACTTGGCCGTTCTGGGGGACGTCT
GCCTTACGGTGTTCGGATGACTGCTATGGGTAGTAGCCCCAATATAGCTAGCAGTGGGGTTGCTAGTGACACCATAGCATTTGGAGAGCA
TCACCTCCCTCCTGTGAGTATGGCATCCACTGTACCTCACTCCCTTCGTCAGGCGAGAGATAACACAATCATGGATCTGCAGACACAGCT
GAAGGAAGTATTAAGAGAAAATGATCTCTTGCGGAAGGATGTGGAAGTAAAGGAGAGCAAATTGAGTTCTTCAATGAATAGCATCAAGAC
CTTCTGGAGCCCAGAGCTGAAGAAGGAACGAGCCCTGAGAAAAGATGAAGCTTCCAAAATCACCATTTGGAAGGAACAGTACAGAGTTGT
ACAGGAGGAAAACCAGCACATGCAGATGACAATCCAGGCTCTCCAGGATGAATTGCGGATCCAGAGGGACCTGAATCAGCTGTTTCAGCA
GGATAGTAGCAGCAGGACTGGCGAACCTTGTGTAGCAGAGCTGACAGAGGAGAACTTTCAGAGGCTTCATGCTGAGCATGAGCGGCAGGC
CAAAGAGCTGTTTCTTCTTCGAAAGACATTGGAGGAAATGGAGCTGCGTATTGAGACTCAAAAGCAGACCCTAAATGCTCGGGATGAATC
CATTAAGAAGCTTCTGGAAATGTTGCAGAGCAAAGGACTTTCTGCCAAGGCTACCGAGGAAGACCATGAGAGAACAAGACGACTGGCAGA
GGCAGAGATGCACGTTCATCACCTAGAAAGCCTTTTGGAGCAGAAGGAAAAAGAGAACAGTATGTTGAGAGAGGAGATGCATCGAAGGTT
TGAGAATGCTCCTGATTCTGCCAAAACAAAAGCTCTGCAAACTGTTATTGAGATGAAGGATTCAAAAATTTCCTCTATGGAGCGTGGGCT
TCGAGACCTGGAAGAGGAAATTCAGATGCTGAAATCGAATGGTGCTTTGAGTACTGAGGAAAGGGAAGAAGAAATGAAGCAAATGGAAGT
GTATCGGAGCCATTCTAAATTTATGAAAAATAAGGTAGAACAACTGAAGGAGGAACTAAGTTCGAAAGAGGCTCAATGGGAGGAGCTGAA
AAAGAAAGCGGCTGGTCTTCAGGCTGAGATTGGCCAGGTGAAACAGGAGCTGTCCAGAAAGGACACAGAACTACTCGCCCTGCAGACAAA
GCTAGAAACACTCACAAACCAGTTCTCAGATAGTAAACAGCACATTGAAGTGTTGAAGGAGTCCTTGACTGCTAAGGAGCAGAGGGCTGC
CATCCTGCAGACTGAGGTGGATGCTCTCCGATTGCGTTTGGAAGAGAAGGAAACCATGTTGAATAAAAAGACAAAACAAATTCAGGATAT
GGCTGAAGAGAAGGGGACACAAGCTGGAGAGATACATGACCTCAAGGACATGTTGGATGTGAAGGAGCGGAAGGTTAATGTTCTTCAGAA
GAAGATTGAAAATCTTCAAGAGCAGCTTAGAGACAAGGAAAAGCAGATGAGCAGCTTGAAAGAACGGGTCAAATCCTTGCAGGCTGACAC
CACCAACACTGACACTGCCTTGACAACTTTGGAGGAGGCCCTTGCAGAGAAAGAGCGGACAATTGAACGCTTAAAGGAGCAGAGGGACAG
AGATGAGCGAGAGAAGCAAGAGGAAATTGATAACTACAAAAAAGATCTTAAAGACTTGAAGGAAAAAGTCAGCCTGTTGCAAGGCGACCT
TTCAGAGAAAGAGGCTTCACTTTTGGATCTGAAAGAGCATGCTTCTTCTCTGGCATCCTCAGGACTGAAAAAGGACTCACGGCTTAAGAC
ACTAGAGATTGCTTTGGAGCAGAAGAAGGAGGAGTGTCTGAAAATGGAATCACAATTGAAAAAGGCACATGAGGCAGCATTGGAAGCCAG
AGCCAGTCCAGAGATGAGTGACCGAATACAGCACTTGGAGAGAGAGATCACCAGGTACAAAGATGAATCTAGCAAGGCCCAGGCAGAAGT
TGATCGACTCTTAGAAATCTTGAAGGAGGTGGAAAATGAGAAGAATGACAAAGATAAGAAGATAGCTGAGTTGGAAAGGCAAGTGAAAGA
CCAGAATAAGAAGGTAGCAAATCTGAAGCACAAGGAACAGGTGGAAAAAAAGAAGAGTGCACAAATGTTAGAGGAGGCGCGACGACGGGA
GGACAATCTCAACGACAGCTCTCAGCAGCTACAGGACAGTCTCCGTAAGAAGGATGACAGGATTGAAGAGCTGGAAGAAGCACTAAGAGA
AAGTGTACAGATAACTGCAGAGCGGGAAATGGTGCTAGCACAAGAGGAATCAGCCAGGACCAATGCTGAAAAACAGGTGTGTGTCCACCG
AAGCACCATCTACCCTGTGGGCCAGTTCTGGGAGGAGGGCTGCGATGTGTGCACCTGCACCGACATGGAGGATGCCGTGATGGGCCTCCG
CGTGGCCCAGTGCTCCCAGAAGCCCTGTGAGGACAGCTGTCGGTCGGGCTTCACTTACGTTCTGCATGAAGGCGAGTGCTGTGGAAGGTG
CCTGCCATCTGCCTGTGAGGTGGTGACTGGCTCACCGCGGGGGGACTCCCAGTCTTCCTGGAAGAGTGTCGGCTCCCAGTGGGCCTCCCC
GGAGAACCCCTGCCTCATCAATGAGTGTGTCCGAGTGAAGGAGGAGGTCTTTATACAACAAAGGAACGTCTCCTGCCCCCAGCTGGAGGT
CCCTGTCTGCCCCTCGGGCTTTCAGCTGAGCTGTAAGACCTCAGCGTGCTGCCCAAGCTGTCGCTGTGAGCGCATGGAGGCCTGCATGCT
CAATGGCACTGTCATTGGGCCCGGGAAGACTGTGATGATCGATGTGTGCACGACCTGCCGCTGCATGGTGCAGGTGGGGGTCATCTCTGG
ATTCAAGCTGGAGTGCAGGAAGACCACCTGCAACCCCTGCCCCCTGGGTTACAAGGAAGAAAATAACACAGGTGAATGTTGTGGGAGATG
TTTGCCTACGGCTTGCACCATTCAGCTAAGAGGAGGACAGATCATGACACTGAAGCGTGATGAGACGCTCCAGGATGGCTGTGATACTCA
CTTCTGCAAGGTCAATGAGAGAGGAGAGTACTTCTGGGAGAAGAGGGTCACAGGCTGCCCACCCTTTGATGAACACAAGTGTCTGGCTGA
GGGAGGTAAAATTATGAAAATTCCAGGCACCTGCTGTGACACATGTGAGGAGCCTGAGTGCAACGACATCACTGCCAGGCTGCAGTATGT
CAAGGTGGGAAGCTGTAAGTCTGAAGTAGAGGTGGATATCCACTACTGCCAGGGCAAATGTGCCAGCAAAGCCATGTACTCCATTGACAT
CAACGATGTGCAGGACCAGTGCTCCTGCTGCTCTCCGACACGGACGGAGCCCATGCAGGTGGCCCTGCACTGCACCAATGGCTCTGTTGT
GTACCATGAGGTTCTCAATGCCATGGAGTGCAAATGCTCCCCCAGGAAGTGCAGCAAGTGAGGCTGCTGCAGCTGCATGGGTGCCTGCTG
CTGCCTGCCTTGGCCTGATGGCCAGGCCAGAGTGCTGCCAGTCCTCTGCATGTTCTGCTCTTGTGCCCTTCTGAGCCCACAATAAAGGCT

>27285_27285_6_ERC1-VWF_ERC1_chr12_1372331_ENST00000589028_VWF_chr12_6085426_ENST00000261405_length(amino acids)=1257AA_BP=872
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT
LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL
HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSK
EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK
KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIE
RLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKA
HEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQM
LEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVCVHRSTIYPVGQFWEEGCDVCTCTDM
EDAVMGLRVAQCSQKPCEDSCRSGFTYVLHEGECCGRCLPSACEVVTGSPRGDSQSSWKSVGSQWASPENPCLINECVRVKEEVFIQQRN
VSCPQLEVPVCPSGFQLSCKTSACCPSCRCERMEACMLNGTVIGPGKTVMIDVCTTCRCMVQVGVISGFKLECRKTTCNPCPLGYKEENN
TGECCGRCLPTACTIQLRGGQIMTLKRDETLQDGCDTHFCKVNERGEYFWEKRVTGCPPFDEHKCLAEGGKIMKIPGTCCDTCEEPECND

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for ERC1-VWF


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for ERC1-VWF


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for ERC1-VWF


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource