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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ERC2-ARHGEF3 (FusionGDB2 ID:27291)

Fusion Gene Summary for ERC2-ARHGEF3

check button Fusion gene summary
Fusion gene informationFusion gene name: ERC2-ARHGEF3
Fusion gene ID: 27291
HgeneTgene
Gene symbol

ERC2

ARHGEF3

Gene ID

26059

50650

Gene nameELKS/RAB6-interacting/CAST family member 2Rho guanine nucleotide exchange factor 3
SynonymsCAST|CAST1|ELKSL|SPBC110|Spc110GEF3|STA3|XPLN
Cytomap

3p14.3

3p14.3

Type of geneprotein-codingprotein-coding
DescriptionERC protein 2CAZ-associated structural proteincytomatrix protein p110rho guanine nucleotide exchange factor 359.8 kDA proteinRho guanine nucleotide exchange factor (GEF) 3RhoGEF proteinexchange factor found in platelets and leukemic and neuronal tissues, XPLN
Modification date2020031320200327
UniProtAcc

O15083

Q8N4T4

Ensembl transtripts involved in fusion geneENST00000288221, ENST00000486496, 
ENST00000498517, ENST00000296315, 
ENST00000413728, ENST00000495373, 
ENST00000497267, ENST00000338458, 
ENST00000496106, 
Fusion gene scores* DoF score9 X 10 X 6=5409 X 7 X 7=441
# samples 1010
** MAII scorelog2(10/540*10)=-2.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/441*10)=-2.1407786557828
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ERC2 [Title/Abstract] AND ARHGEF3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointERC2(56468379)-ARHGEF3(56916382), # samples:2
ERC2(56502276)-ARHGEF3(56992917), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ERC2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ARHGEF3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A1-A0SO-01AERC2chr3

56468379

-ARHGEF3chr3

56916382

-
ChimerDB4OVTCGA-61-2092-01AERC2chr3

56502276

-ARHGEF3chr3

56992917

-


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Fusion Gene ORF analysis for ERC2-ARHGEF3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000288221ENST00000498517ERC2chr3

56468379

-ARHGEF3chr3

56916382

-
5CDS-intronENST00000288221ENST00000296315ERC2chr3

56468379

-ARHGEF3chr3

56916382

-
5CDS-intronENST00000288221ENST00000413728ERC2chr3

56468379

-ARHGEF3chr3

56916382

-
5CDS-intronENST00000288221ENST00000495373ERC2chr3

56468379

-ARHGEF3chr3

56916382

-
5CDS-intronENST00000288221ENST00000497267ERC2chr3

56468379

-ARHGEF3chr3

56916382

-
5UTR-3CDSENST00000288221ENST00000338458ERC2chr3

56502276

-ARHGEF3chr3

56992917

-
5UTR-intronENST00000288221ENST00000296315ERC2chr3

56502276

-ARHGEF3chr3

56992917

-
5UTR-intronENST00000288221ENST00000413728ERC2chr3

56502276

-ARHGEF3chr3

56992917

-
5UTR-intronENST00000288221ENST00000495373ERC2chr3

56502276

-ARHGEF3chr3

56992917

-
5UTR-intronENST00000288221ENST00000496106ERC2chr3

56502276

-ARHGEF3chr3

56992917

-
5UTR-intronENST00000288221ENST00000497267ERC2chr3

56502276

-ARHGEF3chr3

56992917

-
5UTR-intronENST00000288221ENST00000498517ERC2chr3

56502276

-ARHGEF3chr3

56992917

-
In-frameENST00000288221ENST00000338458ERC2chr3

56468379

-ARHGEF3chr3

56916382

-
In-frameENST00000288221ENST00000496106ERC2chr3

56468379

-ARHGEF3chr3

56916382

-
intron-3CDSENST00000486496ENST00000338458ERC2chr3

56468379

-ARHGEF3chr3

56916382

-
intron-3CDSENST00000486496ENST00000338458ERC2chr3

56502276

-ARHGEF3chr3

56992917

-
intron-3CDSENST00000486496ENST00000496106ERC2chr3

56468379

-ARHGEF3chr3

56916382

-
intron-5UTRENST00000486496ENST00000498517ERC2chr3

56468379

-ARHGEF3chr3

56916382

-
intron-intronENST00000486496ENST00000296315ERC2chr3

56468379

-ARHGEF3chr3

56916382

-
intron-intronENST00000486496ENST00000296315ERC2chr3

56502276

-ARHGEF3chr3

56992917

-
intron-intronENST00000486496ENST00000413728ERC2chr3

56468379

-ARHGEF3chr3

56916382

-
intron-intronENST00000486496ENST00000413728ERC2chr3

56502276

-ARHGEF3chr3

56992917

-
intron-intronENST00000486496ENST00000495373ERC2chr3

56468379

-ARHGEF3chr3

56916382

-
intron-intronENST00000486496ENST00000495373ERC2chr3

56502276

-ARHGEF3chr3

56992917

-
intron-intronENST00000486496ENST00000496106ERC2chr3

56502276

-ARHGEF3chr3

56992917

-
intron-intronENST00000486496ENST00000497267ERC2chr3

56468379

-ARHGEF3chr3

56916382

-
intron-intronENST00000486496ENST00000497267ERC2chr3

56502276

-ARHGEF3chr3

56992917

-
intron-intronENST00000486496ENST00000498517ERC2chr3

56502276

-ARHGEF3chr3

56992917

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000288221ERC2chr356468379-ENST00000338458ARHGEF3chr356916382-43139132562460734
ENST00000288221ERC2chr356468379-ENST00000496106ARHGEF3chr356916382-27449132562460734

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000288221ENST00000338458ERC2chr356468379-ARHGEF3chr356916382-0.0022826010.9977174
ENST00000288221ENST00000496106ERC2chr356468379-ARHGEF3chr356916382-0.0052494980.99475056

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Fusion Genomic Features for ERC2-ARHGEF3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ERC2-ARHGEF3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:56468379/chr3:56916382)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ERC2

O15083

ARHGEF3

Q8N4T4

FUNCTION: Thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Seems to act together with BSN. May recruit liprin-alpha proteins to the CAZ.FUNCTION: Promotes cell proliferation. {ECO:0000269|PubMed:22327280}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneERC2chr3:56468379chr3:56916382ENST00000288221-218129_1332191665.3333333333333Compositional biasNote=Poly-His
HgeneERC2chr3:56468379chr3:56916382ENST00000288221-21835_412191665.3333333333333Compositional biasNote=Poly-Gly
TgeneARHGEF3chr3:56468379chr3:56916382ENST00000296315010122_3040527.0DomainDH
TgeneARHGEF3chr3:56468379chr3:56916382ENST00000296315010291_4490527.0DomainPH
TgeneARHGEF3chr3:56468379chr3:56916382ENST00000338458213122_30443559.0DomainDH
TgeneARHGEF3chr3:56468379chr3:56916382ENST00000338458213291_44943559.0DomainPH
TgeneARHGEF3chr3:56468379chr3:56916382ENST00000413728010122_3040533.0DomainDH
TgeneARHGEF3chr3:56468379chr3:56916382ENST00000413728010291_4490533.0DomainPH

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneERC2chr3:56468379chr3:56916382ENST00000288221-218140_9172191665.3333333333333Coiled coilOntology_term=ECO:0000255
HgeneERC2chr3:56468379chr3:56916382ENST00000288221-218879_8822191665.3333333333333Compositional biasNote=Poly-Lys
HgeneERC2chr3:56468379chr3:56916382ENST00000288221-218920_9322191665.3333333333333Compositional biasNote=Poly-His


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Fusion Gene Sequence for ERC2-ARHGEF3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>27291_27291_1_ERC2-ARHGEF3_ERC2_chr3_56468379_ENST00000288221_ARHGEF3_chr3_56916382_ENST00000338458_length(transcript)=4313nt_BP=913nt
GCTCGCTCGGTCTCCGGCTCCGGCGCCGGCTCCTGCTCCTCCTGGCCGCCCGGGGCCAAGGCGACGAGAGGTTGTAAAAATCCATGTGGG
ACGGCCCCGGGGCGAGCATCGGAAAGATCTCTGAGTGGAGTTATTTTCTGGTACGGACTGTGAAAAGAATGCGGTGAAAATTCTGGACAA
TCGTGGAAATATTAGCTCAAACCCCAACTTAATATAGCATTTCTTCTCTTCAGTAACACCTCATAATACAAGAAAAATGTATGGAAGTGC
AAGAACAATCACCAATCTGGAAGGTAGCCCTTCCAGATCCCCTCGTTTGCCAAGGTCTCCTCGTTTGGGCCACCGAAGAACAAGTAGTGG
GGGAGGTGGAGGAACAGGCAAGACTCTGTCTATGGAGAATATCCAGTCCCTCAATGCAGCCTATGCTACGTCTGGACCCATGTATCTGAG
TGATCATGAAGGGGTGGCTTCAACAACCTACCCAAAGGGCACTATGACTCTGGGAAGGGCTACAAATCGAGCTGTATATGGAGGCCGTGT
CACAGCCATGGGGAGTAGTCCCAATATTGCTTCTGCTGGACTTTCCCACACAGATGTCCTTTCATACACAGATCAACATGGTGGGCTGAC
TGGCTCATCCCATCATCACCACCACCAGGTCCCCTCCATGTTGAGGCAGGTAAGAGACAGCACAATGTTAGATCTTCAGGCCCAGCTGAA
AGAACTGCAGAGAGAGAATGACCTCCTCCGGAAAGAGCTAGACATCAAGGACAGCAAATTGGGATCTTCCATGAACAGTATTAAGACTTT
CTGGAGTCCTGAGCTTAAGAAGGAGAGAGTCTTGAGGAAAGAAGAGGCAGCGCGGATGTCTGTCCTCAAGGAGCAGATGAGGGTTTCCCA
TGAAGAAAATCAGCGAAAACGGAAACAGAGCACCCAAGATGAAGATGCTGTTAGCCTTTGCAGTCTCGACATAAGTGAGCCTAGTAATAA
ACGGGTCAAACCCCTTTCCCGAGTCACGTCGCTAGCAAACCTCATCCCGCCCGTGAAGGCCACGCCATTAAAGCGCTTCAGTCAAACCCT
GCAGCGCTCCATTAGCTTCCGCAGTGAGAGCCGCCCTGACATCCTCGCCCCCCGACCCTGGTCCAGAAATGCCGCCCCCTCGAGCACGAA
ACGGAGAGATAGCAAGCTGTGGAGTGAGACCTTCGATGTGTGCGTCAATCAGATGCTTACATCCAAGGAAATCAAACGTCAGGAGGCGAT
CTTTGAGCTTTCCCAAGGAGAAGAAGACTTGATAGAAGACTTGAAATTAGCAAAAAAGGCCTATCATGACCCCATGCTGAAACTCTCCAT
AATGACAGAACAAGAGTTGAATCAAATTTTTGGAACACTGGACTCTCTAATTCCTCTACATGAAGAGCTCCTTAGTCAGCTTCGAGATGT
TAGGAAGCCTGATGGCTCGACTGAACATGTTGGTCCCATCCTCGTGGGCTGGCTCCCTTGCCTCAGCTCCTATGATAGCTACTGCAGCAA
TCAAGTAGCCGCCAAAGCTCTGCTGGACCACAAAAAGCAAGATCACCGAGTCCAGGATTTCCTACAGCGATGTTTAGAATCCCCCTTTAG
CCGCAAACTAGATCTCTGGAATTTCCTCGATATTCCAAGAAGCCGCCTGGTAAAATACCCTCTGCTTCTCCGAGAAATCTTGAGGCACAC
ACCAAATGATAATCCAGATCAGCAGCACTTGGAAGAAGCTATAAATATCATTCAGGGAATTGTGGCAGAAATCAACACCAAGACTGGTGA
ATCTGAATGCCGCTATTATAAAGAGCGGCTTCTTTACTTGGAAGAAGGCCAGAAAGACTCCCTGATCGACAGCTCTCGAGTCTTGTGTTG
TCATGGTGAACTGAAGAACAATCGGGGCGTGAAACTGCATGTTTTCCTGTTCCAAGAAGTGCTTGTGATCACTCGAGCCGTCACCCACAA
TGAGCAGCTTTGCTACCAGCTGTACCGTCAGCCAATCCCCGTGAAAGACCTCCTGCTGGAAGACCTCCAGGATGGAGAAGTGAGGCTGGG
TGGCTCCCTGCGAGGGGCATTCAGCAACAATGAGAGAATTAAAAACTTCTTCAGAGTCAGTTTCAAAAATGGATCCCAAAGTCAGACCCA
CTCGCTACAAGCCAATGACACTTTCAACAAACAGCAGTGGCTTAACTGTATTCGTCAAGCCAAAGAAACAGTTTTGTGTGCTGCCGGGCA
AGCTGGGGTGCTTGACTCCGAGGGATCGTTCCTAAATCCCACCACCGGGAGCAGAGAGCTACAGGGAGAAACAAAACTTGAGCAGATGGA
CCAATCGGACAGTGAGTCAGACTGTAGTATGGACACGAGTGAGGTCAGCCTCGACTGTGAGCGCATGGAACAGACAGACTCTTCCTGTGG
AAACAGCAGGCACGGTGAAAGTAACGTCTGACAGAAGCATGTGCACTTCGGGAAGCAGGCCTGCATCTTACCTGTACAGTATTTGCATTC
CACAGATGGAACGGTTTGGAGAAGCACTTTTTCATACTTTTGTGAAAGTATACATGTTGGCCCAGTCTCTCGTATCTGTACCTTTGTCCC
TAGTACTGTAACTGCCAATCTGTCTGTGTAAGCTGGAATCTGTGGCAACTATTACCCTGTGTTGTATTTCCCAAGTGTCTGGATGGATGG
AGAGGTACTCAAACAAGTTACTTTCAGTTGTCCTGCTGGATTTTAAAAAAATAGAAAAAGAATCTCAAAACTACTGTTTTACATAGATTG
TTTGAAGAGTCCTTCCTCTTGTGCTTCTGTACCACTTTCCCAGCTCTTAGATGTGGTAGCTAAAGGCACGGAATTTAGACGGCCTTGTAA
ATAGGGCATGAGGAACTCATCTGTGTATTGGGATGGTATTAGAGAGAGAATCAGGAAAGACCAACTCATGAAGTGAACTTGGTTTGATCT
TACTCAACTAGAAAGCTTGAAAACATCCCTGGGGATTCTGAAGGCTTAATTTTGCAAAGGAGGATGCATTGTCTGAACTTTGCAACTTCA
TCCAGTGCAAGTTTGATGCAAGAATGTATTAGGACATAAAATAGAGGCTGACCTTAAAAGGGCCAGGACAGAAGCGGCTGCCAGCTCTGA
ATCTTTAACTGAAATGCACATGGCACCAGGAGGTGTCTCTCATAGTTGGTTGCTAGCCTAAAACATCAGAATAGAACCCAAAGGGCTTAG
GAAGGCCTGCCAGGATAACAAGAAGGCCCTGTATTCATTGTGTTTCATCTGCCTAGGCCTACTCATTATTTTAGAGAATGAATGAAGCAA
CAAGGAAGAGAGACCATGACTCTATCGATGACACTGTTTATAGAAACACAGGAGAGGAAGAATTTGGAATGAAAAGCACTTCGTCAGAAC
CTTCTGTGGGAGCCATTGAGAGAAAAGCATGGTCCAGTGCCTTCTGAGAAAGGCCAGAGCTTTGGGCTTTCCTGCTCTGCTTTTGGGTCG
TCAATTTGCCATCTCTGGTTCTGTGCTATAATCAGAATTGTAATTATGTTCTCCAGAGGCCAATTTCATTAACTCTGATTAATTAGAATC
AGCTAGCCAGATTAGTAACCTCTTTGTCCAGCCTTGATTTACAGTGCAGGGTAAAGTGCAGACCTTAAAAACAGCTAAGTACCTAGAAGA
GCTCCCTGCAAGTGTAAATATTAAGGATGACCTGTGCAAAATTATACCCACACCAGCACTAGTGGTAATTATTCTAAATTATTGCCAAAA
AGTTTTTTTTAATCTGTCTTTCAAGTTTACAGAAAAGAAAGCAGTAAATGCATTGATGTCATTTTATTATGTACATATATCATGTGCATT
CAAGCTGTGTGACAAGATATATCAATATAAAAACAAGGTATATACTTTATTATTTTTTGAAAACAAGGATATTGTGATCAATTTTACCCT
GTAAAACATATTTCTGTATTTATAGGTCTTAAACATGATGAATTTTTTCTATTACAAGTTTATTTAAAACTGCTTTCTCAAGTCGTTATT
GATACAGCAAGTGAACCTGCTGCAGACAGAAGCAGAGGAAAGCCAAGAACAGCCTTTATTGGTGAAGAAAAGAATGAATGATTCTTTGTA
GGCGCCATCAGCCACTTTTAGAAGCCATCAGCCAGTGTGTTGGGAAAAGAGGTTTGTCAAGTGTTGGCCTATGGGAAGGTGGTCAATGAA

>27291_27291_1_ERC2-ARHGEF3_ERC2_chr3_56468379_ENST00000288221_ARHGEF3_chr3_56916382_ENST00000338458_length(amino acids)=734AA_BP=218
MYGSARTITNLEGSPSRSPRLPRSPRLGHRRTSSGGGGGTGKTLSMENIQSLNAAYATSGPMYLSDHEGVASTTYPKGTMTLGRATNRAV
YGGRVTAMGSSPNIASAGLSHTDVLSYTDQHGGLTGSSHHHHHQVPSMLRQVRDSTMLDLQAQLKELQRENDLLRKELDIKDSKLGSSMN
SIKTFWSPELKKERVLRKEEAARMSVLKEQMRVSHEENQRKRKQSTQDEDAVSLCSLDISEPSNKRVKPLSRVTSLANLIPPVKATPLKR
FSQTLQRSISFRSESRPDILAPRPWSRNAAPSSTKRRDSKLWSETFDVCVNQMLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPM
LKLSIMTEQELNQIFGTLDSLIPLHEELLSQLRDVRKPDGSTEHVGPILVGWLPCLSSYDSYCSNQVAAKALLDHKKQDHRVQDFLQRCL
ESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESECRYYKERLLYLEEGQKDSLIDSS
RVLCCHGELKNNRGVKLHVFLFQEVLVITRAVTHNEQLCYQLYRQPIPVKDLLLEDLQDGEVRLGGSLRGAFSNNERIKNFFRVSFKNGS
QSQTHSLQANDTFNKQQWLNCIRQAKETVLCAAGQAGVLDSEGSFLNPTTGSRELQGETKLEQMDQSDSESDCSMDTSEVSLDCERMEQT

--------------------------------------------------------------
>27291_27291_2_ERC2-ARHGEF3_ERC2_chr3_56468379_ENST00000288221_ARHGEF3_chr3_56916382_ENST00000496106_length(transcript)=2744nt_BP=913nt
GCTCGCTCGGTCTCCGGCTCCGGCGCCGGCTCCTGCTCCTCCTGGCCGCCCGGGGCCAAGGCGACGAGAGGTTGTAAAAATCCATGTGGG
ACGGCCCCGGGGCGAGCATCGGAAAGATCTCTGAGTGGAGTTATTTTCTGGTACGGACTGTGAAAAGAATGCGGTGAAAATTCTGGACAA
TCGTGGAAATATTAGCTCAAACCCCAACTTAATATAGCATTTCTTCTCTTCAGTAACACCTCATAATACAAGAAAAATGTATGGAAGTGC
AAGAACAATCACCAATCTGGAAGGTAGCCCTTCCAGATCCCCTCGTTTGCCAAGGTCTCCTCGTTTGGGCCACCGAAGAACAAGTAGTGG
GGGAGGTGGAGGAACAGGCAAGACTCTGTCTATGGAGAATATCCAGTCCCTCAATGCAGCCTATGCTACGTCTGGACCCATGTATCTGAG
TGATCATGAAGGGGTGGCTTCAACAACCTACCCAAAGGGCACTATGACTCTGGGAAGGGCTACAAATCGAGCTGTATATGGAGGCCGTGT
CACAGCCATGGGGAGTAGTCCCAATATTGCTTCTGCTGGACTTTCCCACACAGATGTCCTTTCATACACAGATCAACATGGTGGGCTGAC
TGGCTCATCCCATCATCACCACCACCAGGTCCCCTCCATGTTGAGGCAGGTAAGAGACAGCACAATGTTAGATCTTCAGGCCCAGCTGAA
AGAACTGCAGAGAGAGAATGACCTCCTCCGGAAAGAGCTAGACATCAAGGACAGCAAATTGGGATCTTCCATGAACAGTATTAAGACTTT
CTGGAGTCCTGAGCTTAAGAAGGAGAGAGTCTTGAGGAAAGAAGAGGCAGCGCGGATGTCTGTCCTCAAGGAGCAGATGAGGGTTTCCCA
TGAAGAAAATCAGCGAAAACGGAAACAGAGCACCCAAGATGAAGATGCTGTTAGCCTTTGCAGTCTCGACATAAGTGAGCCTAGTAATAA
ACGGGTCAAACCCCTTTCCCGAGTCACGTCGCTAGCAAACCTCATCCCGCCCGTGAAGGCCACGCCATTAAAGCGCTTCAGTCAAACCCT
GCAGCGCTCCATTAGCTTCCGCAGTGAGAGCCGCCCTGACATCCTCGCCCCCCGACCCTGGTCCAGAAATGCCGCCCCCTCGAGCACGAA
ACGGAGAGATAGCAAGCTGTGGAGTGAGACCTTCGATGTGTGCGTCAATCAGATGCTTACATCCAAGGAAATCAAACGTCAGGAGGCGAT
CTTTGAGCTTTCCCAAGGAGAAGAAGACTTGATAGAAGACTTGAAATTAGCAAAAAAGGCCTATCATGACCCCATGCTGAAACTCTCCAT
AATGACAGAACAAGAGTTGAATCAAATTTTTGGAACACTGGACTCTCTAATTCCTCTACATGAAGAGCTCCTTAGTCAGCTTCGAGATGT
TAGGAAGCCTGATGGCTCGACTGAACATGTTGGTCCCATCCTCGTGGGCTGGCTCCCTTGCCTCAGCTCCTATGATAGCTACTGCAGCAA
TCAAGTAGCCGCCAAAGCTCTGCTGGACCACAAAAAGCAAGATCACCGAGTCCAGGATTTCCTACAGCGATGTTTAGAATCCCCCTTTAG
CCGCAAACTAGATCTCTGGAATTTCCTCGATATTCCAAGAAGCCGCCTGGTAAAATACCCTCTGCTTCTCCGAGAAATCTTGAGGCACAC
ACCAAATGATAATCCAGATCAGCAGCACTTGGAAGAAGCTATAAATATCATTCAGGGAATTGTGGCAGAAATCAACACCAAGACTGGTGA
ATCTGAATGCCGCTATTATAAAGAGCGGCTTCTTTACTTGGAAGAAGGCCAGAAAGACTCCCTGATCGACAGCTCTCGAGTCTTGTGTTG
TCATGGTGAACTGAAGAACAATCGGGGCGTGAAACTGCATGTTTTCCTGTTCCAAGAAGTGCTTGTGATCACTCGAGCCGTCACCCACAA
TGAGCAGCTTTGCTACCAGCTGTACCGTCAGCCAATCCCCGTGAAAGACCTCCTGCTGGAAGACCTCCAGGATGGAGAAGTGAGGCTGGG
TGGCTCCCTGCGAGGGGCATTCAGCAACAATGAGAGAATTAAAAACTTCTTCAGAGTCAGTTTCAAAAATGGATCCCAAAGTCAGACCCA
CTCGCTACAAGCCAATGACACTTTCAACAAACAGCAGTGGCTTAACTGTATTCGTCAAGCCAAAGAAACAGTTTTGTGTGCTGCCGGGCA
AGCTGGGGTGCTTGACTCCGAGGGATCGTTCCTAAATCCCACCACCGGGAGCAGAGAGCTACAGGGAGAAACAAAACTTGAGCAGATGGA
CCAATCGGACAGTGAGTCAGACTGTAGTATGGACACGAGTGAGGTCAGCCTCGACTGTGAGCGCATGGAACAGACAGACTCTTCCTGTGG
AAACAGCAGGCACGGTGAAAGTAACGTCTGACAGAAGCATGTGCACTTCGGGAAGCAGGCCTGCATCTTACCTGTACAGTATTTGCATTC
CACAGATGGAACGGTTTGGAGAAGCACTTTTTCATACTTTTGTGAAAGTATACATGTTGGCCCAGTCTCTCGTATCTGTACCTTTGTCCC
TAGTACTGTAACTGCCAATCTGTCTGTGTAAGCTGGAATCTGTGGCAACTATTACCCTGTGTTGTATTTCCCAAGTGTCTGGATGGATGG

>27291_27291_2_ERC2-ARHGEF3_ERC2_chr3_56468379_ENST00000288221_ARHGEF3_chr3_56916382_ENST00000496106_length(amino acids)=734AA_BP=218
MYGSARTITNLEGSPSRSPRLPRSPRLGHRRTSSGGGGGTGKTLSMENIQSLNAAYATSGPMYLSDHEGVASTTYPKGTMTLGRATNRAV
YGGRVTAMGSSPNIASAGLSHTDVLSYTDQHGGLTGSSHHHHHQVPSMLRQVRDSTMLDLQAQLKELQRENDLLRKELDIKDSKLGSSMN
SIKTFWSPELKKERVLRKEEAARMSVLKEQMRVSHEENQRKRKQSTQDEDAVSLCSLDISEPSNKRVKPLSRVTSLANLIPPVKATPLKR
FSQTLQRSISFRSESRPDILAPRPWSRNAAPSSTKRRDSKLWSETFDVCVNQMLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPM
LKLSIMTEQELNQIFGTLDSLIPLHEELLSQLRDVRKPDGSTEHVGPILVGWLPCLSSYDSYCSNQVAAKALLDHKKQDHRVQDFLQRCL
ESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESECRYYKERLLYLEEGQKDSLIDSS
RVLCCHGELKNNRGVKLHVFLFQEVLVITRAVTHNEQLCYQLYRQPIPVKDLLLEDLQDGEVRLGGSLRGAFSNNERIKNFFRVSFKNGS
QSQTHSLQANDTFNKQQWLNCIRQAKETVLCAAGQAGVLDSEGSFLNPTTGSRELQGETKLEQMDQSDSESDCSMDTSEVSLDCERMEQT

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Fusion Gene PPI Analysis for ERC2-ARHGEF3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ERC2-ARHGEF3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ERC2-ARHGEF3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource