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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:ERCC2-NOVA2 (FusionGDB2 ID:27309) |
Fusion Gene Summary for ERCC2-NOVA2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ERCC2-NOVA2 | Fusion gene ID: 27309 | Hgene | Tgene | Gene symbol | ERCC2 | NOVA2 | Gene ID | 2068 | 4858 |
| Gene name | ERCC excision repair 2, TFIIH core complex helicase subunit | NOVA alternative splicing regulator 2 | |
| Synonyms | COFS2|EM9|TFIIH|TTD|TTD1|XPD | ANOVA|NOVA3 | |
| Cytomap | 19q13.32 | 19q13.32 | |
| Type of gene | protein-coding | protein-coding | |
| Description | general transcription and DNA repair factor IIH helicase subunit XPDBTF2 p80CXPDDNA excision repair protein ERCC-2DNA repair protein complementing XP-D cellsTFIIH 80 kDa subunitTFIIH basal transcription factor complex 80 kDa subunitTFIIH basal tran | RNA-binding protein Nova-2astrocytic NOVA1-like RNA-binding proteinneuro-oncological ventral antigen 2neuro-oncological ventral antigen 3 | |
| Modification date | 20200315 | 20200322 | |
| UniProtAcc | P18074 | Q9UNW9 | |
| Ensembl transtripts involved in fusion gene | ENST00000221481, ENST00000391940, ENST00000391944, ENST00000391945, ENST00000485403, | ENST00000599462, ENST00000263257, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 2 X 2 X 2=8 |
| # samples | 3 | 2 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: ERCC2 [Title/Abstract] AND NOVA2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | ERCC2(45871888)-NOVA2(46444203), # samples:2 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ERCC2 | GO:0006283 | transcription-coupled nucleotide-excision repair | 8663148 |
| Hgene | ERCC2 | GO:0006366 | transcription by RNA polymerase II | 9852112 |
| Hgene | ERCC2 | GO:0045893 | positive regulation of transcription, DNA-templated | 8692842 |
| Hgene | ERCC2 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 8692841 |
| Fusion gene breakpoints across ERCC2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across NOVA2 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | BLCA | TCGA-DK-AA6P-01A | ERCC2 | chr19 | 45871888 | - | NOVA2 | chr19 | 46444203 | - |
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Fusion Gene ORF analysis for ERCC2-NOVA2 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000221481 | ENST00000599462 | ERCC2 | chr19 | 45871888 | - | NOVA2 | chr19 | 46444203 | - |
| 5CDS-intron | ENST00000391940 | ENST00000599462 | ERCC2 | chr19 | 45871888 | - | NOVA2 | chr19 | 46444203 | - |
| 5CDS-intron | ENST00000391944 | ENST00000599462 | ERCC2 | chr19 | 45871888 | - | NOVA2 | chr19 | 46444203 | - |
| 5CDS-intron | ENST00000391945 | ENST00000599462 | ERCC2 | chr19 | 45871888 | - | NOVA2 | chr19 | 46444203 | - |
| 5CDS-intron | ENST00000485403 | ENST00000599462 | ERCC2 | chr19 | 45871888 | - | NOVA2 | chr19 | 46444203 | - |
| In-frame | ENST00000221481 | ENST00000263257 | ERCC2 | chr19 | 45871888 | - | NOVA2 | chr19 | 46444203 | - |
| In-frame | ENST00000391940 | ENST00000263257 | ERCC2 | chr19 | 45871888 | - | NOVA2 | chr19 | 46444203 | - |
| In-frame | ENST00000391944 | ENST00000263257 | ERCC2 | chr19 | 45871888 | - | NOVA2 | chr19 | 46444203 | - |
| In-frame | ENST00000391945 | ENST00000263257 | ERCC2 | chr19 | 45871888 | - | NOVA2 | chr19 | 46444203 | - |
| In-frame | ENST00000485403 | ENST00000263257 | ERCC2 | chr19 | 45871888 | - | NOVA2 | chr19 | 46444203 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000391945 | ERCC2 | chr19 | 45871888 | - | ENST00000263257 | NOVA2 | chr19 | 46444203 | - | 7650 | 438 | 24 | 1520 | 498 |
| ENST00000391944 | ERCC2 | chr19 | 45871888 | - | ENST00000263257 | NOVA2 | chr19 | 46444203 | - | 7600 | 388 | 7 | 1470 | 487 |
| ENST00000485403 | ERCC2 | chr19 | 45871888 | - | ENST00000263257 | NOVA2 | chr19 | 46444203 | - | 7719 | 507 | 72 | 1589 | 505 |
| ENST00000391940 | ERCC2 | chr19 | 45871888 | - | ENST00000263257 | NOVA2 | chr19 | 46444203 | - | 7582 | 370 | 10 | 1452 | 480 |
| ENST00000221481 | ERCC2 | chr19 | 45871888 | - | ENST00000263257 | NOVA2 | chr19 | 46444203 | - | 7589 | 377 | 17 | 1459 | 480 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000391945 | ENST00000263257 | ERCC2 | chr19 | 45871888 | - | NOVA2 | chr19 | 46444203 | - | 0.001164921 | 0.99883515 |
| ENST00000391944 | ENST00000263257 | ERCC2 | chr19 | 45871888 | - | NOVA2 | chr19 | 46444203 | - | 0.001173344 | 0.9988267 |
| ENST00000485403 | ENST00000263257 | ERCC2 | chr19 | 45871888 | - | NOVA2 | chr19 | 46444203 | - | 0.001189564 | 0.9988104 |
| ENST00000391940 | ENST00000263257 | ERCC2 | chr19 | 45871888 | - | NOVA2 | chr19 | 46444203 | - | 0.001178349 | 0.9988217 |
| ENST00000221481 | ENST00000263257 | ERCC2 | chr19 | 45871888 | - | NOVA2 | chr19 | 46444203 | - | 0.001165379 | 0.99883467 |
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Fusion Genomic Features for ERCC2-NOVA2 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for ERCC2-NOVA2 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:45871888/chr19:46444203) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ERCC2 | NOVA2 |
| FUNCTION: ATP-dependent 5'-3' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATP-dependent helicase activity of XPD/ERCC2 is required for DNA opening. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. XPD/ERCC2 acts by forming a bridge between CAK and the core-TFIIH complex. Involved in the regulation of vitamin-D receptor activity. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation. Might have a role in aging process and could play a causative role in the generation of skin cancers. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:15494306, ECO:0000269|PubMed:20797633, ECO:0000269|PubMed:8413672}. | FUNCTION: May regulate RNA splicing or metabolism in a specific subset of developing neurons (By similarity). Binds single strand RNA. {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ERCC2 | chr19:45871888 | chr19:46444203 | ENST00000391940 | - | 5 | 13 | 42_49 | 96 | 406.0 | Nucleotide binding | ATP |
| Hgene | ERCC2 | chr19:45871888 | chr19:46444203 | ENST00000391945 | - | 5 | 23 | 42_49 | 120 | 761.0 | Nucleotide binding | ATP |
| Hgene | ERCC2 | chr19:45871888 | chr19:46444203 | ENST00000485403 | - | 4 | 12 | 42_49 | 96 | 406.0 | Nucleotide binding | ATP |
| Tgene | NOVA2 | chr19:45871888 | chr19:46444203 | ENST00000263257 | 2 | 4 | 232_405 | 132 | 493.0 | Compositional bias | Note=Ala-rich | |
| Tgene | NOVA2 | chr19:45871888 | chr19:46444203 | ENST00000263257 | 2 | 4 | 332_393 | 132 | 493.0 | Compositional bias | Note=Gly-rich | |
| Tgene | NOVA2 | chr19:45871888 | chr19:46444203 | ENST00000263257 | 2 | 4 | 130_196 | 132 | 493.0 | Domain | KH 2 | |
| Tgene | NOVA2 | chr19:45871888 | chr19:46444203 | ENST00000263257 | 2 | 4 | 406_473 | 132 | 493.0 | Domain | KH 3 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ERCC2 | chr19:45871888 | chr19:46444203 | ENST00000391940 | - | 5 | 13 | 7_283 | 96 | 406.0 | Domain | Helicase ATP-binding |
| Hgene | ERCC2 | chr19:45871888 | chr19:46444203 | ENST00000391945 | - | 5 | 23 | 7_283 | 120 | 761.0 | Domain | Helicase ATP-binding |
| Hgene | ERCC2 | chr19:45871888 | chr19:46444203 | ENST00000485403 | - | 4 | 12 | 7_283 | 96 | 406.0 | Domain | Helicase ATP-binding |
| Hgene | ERCC2 | chr19:45871888 | chr19:46444203 | ENST00000391940 | - | 5 | 13 | 234_237 | 96 | 406.0 | Motif | Note=DEAH box |
| Hgene | ERCC2 | chr19:45871888 | chr19:46444203 | ENST00000391940 | - | 5 | 13 | 682_695 | 96 | 406.0 | Motif | Nuclear localization signal |
| Hgene | ERCC2 | chr19:45871888 | chr19:46444203 | ENST00000391945 | - | 5 | 23 | 234_237 | 120 | 761.0 | Motif | Note=DEAH box |
| Hgene | ERCC2 | chr19:45871888 | chr19:46444203 | ENST00000391945 | - | 5 | 23 | 682_695 | 120 | 761.0 | Motif | Nuclear localization signal |
| Hgene | ERCC2 | chr19:45871888 | chr19:46444203 | ENST00000485403 | - | 4 | 12 | 234_237 | 96 | 406.0 | Motif | Note=DEAH box |
| Hgene | ERCC2 | chr19:45871888 | chr19:46444203 | ENST00000485403 | - | 4 | 12 | 682_695 | 96 | 406.0 | Motif | Nuclear localization signal |
| Tgene | NOVA2 | chr19:45871888 | chr19:46444203 | ENST00000263257 | 2 | 4 | 32_99 | 132 | 493.0 | Domain | KH 1 | |
| Tgene | NOVA2 | chr19:45871888 | chr19:46444203 | ENST00000263257 | 2 | 4 | 10_26 | 132 | 493.0 | Motif | Bipartite nuclear localization signal |
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Fusion Gene Sequence for ERCC2-NOVA2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >27309_27309_1_ERCC2-NOVA2_ERCC2_chr19_45871888_ENST00000221481_NOVA2_chr19_46444203_ENST00000263257_length(transcript)=7589nt_BP=377nt ACAGTCCGGCCGGCGCCATGAAGCTCAACGTGGACGGGCTCCTGGTCTACTTCCCGTACGACTACATCTACCCCGAGCAGTTCTCCTACA TGCGGGAGCTCAAACGCACGCTGGACGCCAAGGGTCATGGAGTCCTGGAGATGCCCTCAGGCACCGGGAAGACAGTATCCCTGTTGGCCC TGATCATGGCATACCAGAGAGCATATCCGCTGGAGGTGACCAAACTCATCTACTGCTCAAGAACTGTGCCAGAGATTGAGAAGGTGATTG AAGAGCTTCGAAAGTTGCTCAACTTCTATGAGAAGCAGGAGGGCGAGAAGCTGCCGTTTCTGGGACTGGCTCTGAGCTCCCGCAAAAACT TGTGTATTCACCCTGAGGCCAAGCTGATCGTCCCCAACAGCACGGCGGGCCTGATCATCGGCAAGGGAGGCGCCACGGTGAAAGCCGTGA TGGAACAGTCAGGAGCATGGGTGCAGCTGTCCCAGAAGCCGGAGGGCATCAACCTGCAGGAGCGCGTGGTGACGGTCAGCGGCGAGCCCG AGCAGGTGCACAAGGCCGTGAGCGCCATCGTGCAGAAGGTACAAGAAGACCCCCAGAGCAGCAGCTGCCTCAACATCAGCTACGCCAACG TGGCAGGCCCCGTGGCCAACTCCAACCCCACCGGCTCTCCGTACGCCAGCCCCGCGGATGTGCTGCCAGCCGCGGCCGCAGCGTCGGCCG CCGCCGCCTCCGGCCTGCTGGGCCCCGCCGGGCTGGCTGGCGTGGGGGCCTTTCCCGCCGCGCTGCCCGCCTTCTCAGGCACCGACCTGC TGGCCATCAGCACGGCGCTTAACACGCTGGCAAGTTACGGCTACAACACCAACTCCCTGGGCCTGGGCCTCAACTCGGCCGCAGCTTCCG GCGTCCTGGCCGCCGTGGCCGCCGGGGCCAACCCAGCAGCCGCCGCCGCCGCCAACCTCCTGGCATCCTACGCGGGCGAGGCCGGGGCCG GGCCAGCCGGAGGGGCCGCCCCGCCGCCGCCCCCGCCTCCCGGAGCCCTGGGGTCCTTTGCGTTGGCCGCAGCCGCCAACGGCTACCTCG GGGCCGGGGCGGGCGGCGGGGCGGGCGGAGGGGGCGGCCCGCTGGTGGCCGCTGCAGCCGCGGCCGGGGCGGCCGGGGGCTTCCTGACGG CGGAGAAGCTGGCGGCTGAGAGTGCCAAGGAGCTGGTGGAGATTGCGGTGCCTGAGAACCTGGTGGGAGCCATCCTGGGGAAGGGGGGCA AGACGTTGGTGGAGTACCAGGAGCTGACGGGCGCTCGCATCCAGATCTCCAAGAAGGGCGAGTTCCTGCCAGGCACGCGGAACCGGCGGG TCACCATCACGGGCAGCCCCGCGGCCACGCAAGCCGCTCAATACCTCATCAGTCAGCGGGTCACCTACGAGCAGGGAGTGAGGGCCTCAA ACCCCCAGAAAGTGGGATGAGGCCTGTGGTGTGTGCTCCCACCCTTTTCTCTCCTCCCATCTCCTCCTCTTCCCTCTCCTCCTCCCCCCC AACTCCTGACCTCAGCTTGGTGTAGTCCTGCTCCTCTTGGGATGGGGCTGGGGTAGGCCCGACTGCACCCTCCCCTTCTGGTAGTCATAG GCAGGATTGAGTGACGGTTGGGAAGGGGGCTCAGAAGCCCCCTCCCCAGCCCGGAACTGACCCCTCCTTCCTCCCTCCCTGTGCTTGGCT GGGCCTGACCCTTCCTGTCCCAGGGCCCAGGTCTGTGTGATATCTGTATATATTGCATTTTGTTGATTTTAATAGAAAACAAAGCGTTAT TTTCTCTTTCTTTCCCTCCTTTTTTTTTTTTTTTTTTTTTTTGGTAAGGATTTTTTCCCCCTTTATAAGTTTTTGTTTCCATATGGGAGG AGGGGAGGGAGCCTCTGGGTCACCCAGAATGAGGGGCCTTCCCAAAACACAACACCCCACCTCTCTGCTTTCAGTTCTAGATCTGAGGGA AGCCATGGGAGTAGAGGTAGCAGAGGCGTCTGAGCTGAAATGGGGCATTTGGAGCAAGGACCCCAGAGTTCCCAGATCTTCTCAGCTACT CTCCTCCCACTGGAGCTGTCCCTCCTAGGTGGGAATGTTCACTCTTTTGTTGTCAGGTTGTATGGGGGGGCAGGGACAGTGCTGCTGGGA AGGATGCCAGCTCTGGGATTGGGCCAGTCCTGTGGGCAAGACTTGCAAGAGGCTGGATCAACTTGGTGTGGTATCTCTGATGGCTTAGAG TAATGGCAATGAGGGTCTCTGTTGTGATGTCACTGAGTACTTTCTGGGGTGCTTCTGGGCACCCCTTATGATGTCACAGGAAGCAGTTCC TCAGAGGTTACTTCCTGTGAACATAAGGGAGCAGGTACTTCCTGTGATGTCTCAATGAGTTCTTCCTTGAAGGTCACTTTGGTGATATCA TGGGAAGGTGTACTTCCGGTGATGCCTAGAGGTCACGTCCTGTGATGTCATTAGGCTGAAGCATGTACTTCCTGTATTGGACAGTGACCA GTCTCTGACCTGCCTTCTCCCTCCACACCCTTCTTTGGTGGGTGTTGGCCTGGGGGTCTTCCTAGGAAGAGAATAAGGCACGGGACTTGG ATCCAATCTGGAGGACTCTAACGGAAAAAAACCAATATTGTCAGGGTCATCTCCATTCAAACACGTCAAGTCTGCGAACTCGCCCTGGAG GGAGGGGTGGGAGATGGACCTAGTGCAAACTACTGTTAAAGACCTCCCTTCCCACCCCTGCCTTTTGTGTGCATGCCTGTGTCTGCGTGG CTTTGTTTCATTGAATCGGGTGAGCCAAGTGTGTGGTGGCTCTGTCAGGCCAGTATGGCCAGGTGTAGAGTTCAGTGAGCCATAGTAGGG TCCCTTGGGCCAGAATGCTTCGTGTGGTCTGATAGGTTAGATTGGTTTGGTGGCTTCCAGCAAGCTGGCATACTTCGGTGATGTCTGATG GATCAGAATGTTTTGGTGTGCTCACCAGGGGCTCTGGAGAACTAGAATGTTCTGATGGAGTCTGACAAGCCAGGCGGCCTTGAGAGTTGG TTTAGGAGTGGCTCCCTGAGTGCTGTGGCTGTGGTCAGCTCTAAGGACCTGTTGGCAGACTGAGATTTCAGGGCCTGACAACCATGTAGA CTAGGATAGCTGAGACCTCCCTCTACCCCCACCCATCTCCCTCTCTTCCTTGGAGACCACCTCCACTTTCTCCAACCCAAAGCAGGGCGC CCAGTGCCCTGGTTCCATCATCAGCATCTCTGGGGGAGGGGCGCCCCATGCCCACCCTCTCCCCCATTTGTCCGCCTCCTAGGTCTTCCA AACCCTTTTCTTCTCTATGACTTTGGGGGAAATCCAGCCTCCTTGTCTCTCTCCTAAAAAAGGAGGGAAGAAAAGCCACAGAGACAATTC CTGCCCCTAAAGCCTAGGAGATCCCTCTCCCTTGCTAGAGAGCCACCCCCAAATCAAAATGTGAAAATCCCTAGAAAGCAATAGCCTTCG AGGTACCTTGCACTGAATTTCCCACCCCAGCCCTTCCACCCGATGGGAGGCTGTAACTTGGGCACTGGGGTGACTTTTTCCATGCCCTTG TCATCTCCAGGGTGGGAGGCAGGCCCCACTTCCCCTCCCCTATCCCCCACTTCCCATTGTTGTTGCCCCACCCCTAATCTCCAGACTGAA CCCAGATGGAGATCTGAGTGCCAAAACAATTCTTGATGTAACTTTGTACATATCTTCTACTACCGTTGGGGGCTCTTGGGGTTAGAGGTG GGGGCGGCTCTGTGGGCCATTGCTCCCCTCCACCTCTCAAAAGACCTTACAGTATTTCACAGTATCTCTACCCGCACGCGAGTATTACAG TATCTAGCTGGAATATCCCCCTACAGCCCCCCAGGACCCTATGAGGAAGGGAAGGAGCCAGGGAGAGTGAAGTAAGGTCTGGGACTGGGG AGGTGGGATCTGAATGAACTCATTTGCATATCATTTGCATCCTCCGCTTGGCAGCCGCTTTCTACAAACTCATTCACTGGAGTCTGGGTC CCAATCAGCCGGGTCCAGGACTCCTCTCACACAGACACATCTCCGGAGGCTGGGCCTCCTGAAAAGTGTTTGCTTGGGGTGTCTGTGTAA CAACCCCTCCCTATTCATATTTCTTGGGGACCCCCTACCCAGCCAGCCAGGGTGATCTGAAAGGTATACTTTGCTAGCTCAGTGAGCTAG TTCACTCACCATGTTGGTGAGCAGAGAGCCACACCTTTCCCCATTTTACCTTGGGAAACTCACTCCACCATCTTTGCCATCTCTTGAAAG TCCCTTCTGCAATCTGACCTCAATCTTTTGTGCTGCAGTTTGTCCAGAGGGGACACAGATGTGGGGTCAGGGATGAGGATTATTGAAAAA CCCATCATCTCTTTTTTTTTCCCCGTCTCCCTATTAGCCAATCCGATCTCAGAGTCTCTGAGTGGCCTCCTTGCACCCTTCTCTTCAGCA CCCAGTAGGTGCTTAATAAGTGTTTGCTGCATTGGATTATCTCCCTATTCCTTCTCATTTGCCCTCTAGCTTCCCATACCTTCTCCAAGT GTCTTCCTCCCTTTCTTTGTCTGGCTCCCTATGACTTTCTATTTTTTTTTCCTCCGTGTGGTTCCCATTGTTTTCTGTCCTGTCTCTATC TTAGTCTTTGTCTGTCTTCCTCCTTTCCTCAAATGTCTCAACTCTCTCTCCCCAATTTCCCCATTTAAAAAAAAAAAAAAGTGCCAAACT TCCTTGGAACTGAGCCGCTCTGGGGGGAGAGGACCTTGGATAGAGGGGAGGAAATGGGACCATTTCTCTTTGAGGAGGTCCCTAAGAGGC ATTGCAAAAGTGTGGACATGGAGCTAAATTGGGTCCCCCTTCCACAGCCCTCCCACCCTGAGTTTTTCTTAGAATCTTTGTAAGAAAAAA AAAAAAAGACAGAAAAAAGCTCTCCTTTTCAACTTACCCCTATCCTTTTGGGTCCCCCCAAATTCCACCAGCCAAGGAGAATCCCACTTG CCAACTTCCTGGCAAATCTATGGAAACTGGGGAGGAGGAGACAAGCTCAACTCCTCCTCTGCTAGCCCAAGGGGCGGTACCAACTGGATT CAAGAGAAGGACCTCAAAGCTCCTATGAGAAGAGGGGGTTCGATGTGCCAAATTAACCTCCTTCATCCCCCATCTCAGGGGGCTCTGAGC CAACCTGCCCAGCCACCTTCTTCTGCCCTGTCCCAGCCACCTCTACATGGGCAAGGAGGCTTCACTGCAATAATTAGTAGGGGTGGTGAT CAGAAGACAATGATTTTGCCGTTTCTATCTGCCCTAACGCCTACCCTGGACTTGTAGTTGGGAATTATGGGTATCCCAAGTGGATGTTGA TAAAAGCCGACCTATAGATGGTTGGGGACCTCTACTTGGAACACCAGGGTGTCGCTTATCTCCGAGGTGTATTTCCTCTCCCCTCTGGAC CACCAAATCCTTCAATATCCCCTCATTCTGTTTCTCCTCCCTGTTCCTCCATCCCACATCCTCCTTCTTACTTTGTTTTGATTGGTGGCC AATTGTTTGGAAAATGAGAGGAGTCCCCCTGAATGGATGATTGCTGTTTCAGGACCGGGATTAGAGGCTGTGATAGACTGTGCAGTGGCA AAAGTATTAACAAGAGTGGCGATGAGGATGGCAGTTGGGGCGTCCAGGCTGCTGACTGAGTGCCCGCCTGTCGGTACAGCCAGCCAGGCC TTCGACAAGCACCTGCCTGGAAACCGGGCTCGCTGTCCTGAAAGCCTGGACTGGATGTCACGATGGGGAGAACGGGATCGCGATACCCAA GCTGGGGCACAGGCGAGCCAGGGACACTGGTTTACTGGGGTGATAACACCCAGCCCTGCTATCGCGATCCGTTTGCACTGTGGTCAGCTG TCTCCACGCCGTGGTTGGAGAGGGCTTGTCTCCGGGCGCCACTGCTGGTGTGTATGGTCTGTCTTAGTGTCCCCTGCAAGTTGCATTGGA GATTGCTGGGTGGCAGGGAGGGAAATGGGAAGAGAATCTGTGGGGTCATGGTGGTGAAGGCTGCTGGTTTTTAATCCCTTCTCAACCAGT CCAGGACACTTGTCTCCCAGAGATAACTGGGGGGGGACTGCCTAACCCCCCCTCCCCCACCCCTTTCCCTACCCCACCTCTCCCCCCAAA ACCACCAACCTCTCATCTTCTAAGTGACTCCATCACCACCGGCCACCGGGACCTGCGGCCTCATTGCTCCAGCCCGCCCCACTCGACCGT CAGACTCGCTCATCGAACTCTTTTTGATTAACCCTTTCTGTGTTCATCCCACGGAAAACTGTGTGTCCGGCAGGGGGGAGGGGGGAGGCT AGGGGCAGTTGCTACCTTTCCTCCATCTCCTCCCACCACCCATGCCTCCCCACCCGCACCCCATCCCATGCCCCACCCCCATCCCTCACC CCTAGGGTCTGCCCCACCCTGGGGATTGACATCCTCTATAAATATCTATGCTATTTGGCTTTGTCCCTTTAAAAGGCGGGTCCAGGGGCG TGGCCTCCCTCAAATGGAGCGCTCACTCTGACCCCCTCCTTCGTGTGCCCCCCACACACTCCCCACGCCTTCATTGTAAATAGTCACTTT TGTACTGGGTTTGAGCCAGGGGACGTGGGGAGTCATTTTTCTTTTCTTTATGTTGGCATCTCAGGCCACTGGAGGCATGGCCCACATCCC GGGTCGATTTGGGAGAATTTTAAGGTATGTCCCCTCACCTGTCCCCATCGCTAAGGATTTCAAGCTATCAGTATTACTCTAGAGGGATGG GGTGCATAGATTCCCCGGCAGGGTGGTGGGAGAGGTGTGGAAAGGTGTAGTCTGGGAGGATGCCTCCGTTTTCCCCTTCTGTGAAATGGA TTCATCCTCCAATTTCCCTGAGGAGCCTCAGTGAGATAATGGTGGAGTCAGAGGAGCTAGAACCTCTCTTCCCCCTTTCTCTGTTGGAGA CAGGGTAGCAGAAGAATGGGGGACAGGGGAGGCTGCAGGGCCATCTTTGGAGAACCGATTGCTAAATCCTTCTTAGGACCTTAAGGTAGC CTCCTCTCCAGGCTTGTTCTCCCTCTTGGAATATGGGGAGGACTGGAGGACCTCTAAGGTCCCTTGGTTCTCCCCAGTCCTTAGATTAAA AGGCCCAGGCCCCAGGCTGGCCCCCTGCCTGCTGTCCCACTCCTTCATTCCATTTCTTGGAATGTGGCCATGCCTCCAGTGCCTCCATTC AACCCCCTCTAACTGATTCCTTCCATCCTCTGCGACCAGAGACGCCGCCCGCCTCCTGCCCACCACCTCCAGAAGCTCCTGGCTGGGGTG CACTGCCGTCTCCTCCCACTCCCCACATTGCCATGCCTGGGCCACGCCCACCCCACCCACTCACCCACCCCCAGTGTCCGTTGTGTGACC TAGTGCACCATGTATTAGCTTCCATGGCCCCCACCCCAGCCCCCACCACACCCCCTTTCCCCACCCCTTTCCCCTCGGCGACTTCACCTT >27309_27309_1_ERCC2-NOVA2_ERCC2_chr19_45871888_ENST00000221481_NOVA2_chr19_46444203_ENST00000263257_length(amino acids)=480AA_BP=120 MKLNVDGLLVYFPYDYIYPEQFSYMRELKRTLDAKGHGVLEMPSGTGKTVSLLALIMAYQRAYPLEVTKLIYCSRTVPEIEKVIEELRKL LNFYEKQEGEKLPFLGLALSSRKNLCIHPEAKLIVPNSTAGLIIGKGGATVKAVMEQSGAWVQLSQKPEGINLQERVVTVSGEPEQVHKA VSAIVQKVQEDPQSSSCLNISYANVAGPVANSNPTGSPYASPADVLPAAAAASAAAASGLLGPAGLAGVGAFPAALPAFSGTDLLAISTA LNTLASYGYNTNSLGLGLNSAAASGVLAAVAAGANPAAAAAANLLASYAGEAGAGPAGGAAPPPPPPPGALGSFALAAAANGYLGAGAGG GAGGGGGPLVAAAAAAGAAGGFLTAEKLAAESAKELVEIAVPENLVGAILGKGGKTLVEYQELTGARIQISKKGEFLPGTRNRRVTITGS -------------------------------------------------------------- >27309_27309_2_ERCC2-NOVA2_ERCC2_chr19_45871888_ENST00000391940_NOVA2_chr19_46444203_ENST00000263257_length(transcript)=7582nt_BP=370nt GGCCGGCGCCATGAAGCTCAACGTGGACGGGCTCCTGGTCTACTTCCCGTACGACTACATCTACCCCGAGCAGTTCTCCTACATGCGGGA GCTCAAACGCACGCTGGACGCCAAGGGTCATGGAGTCCTGGAGATGCCCTCAGGCACCGGGAAGACAGTATCCCTGTTGGCCCTGATCAT GGCATACCAGAGAGCATATCCGCTGGAGGTGACCAAACTCATCTACTGCTCAAGAACTGTGCCAGAGATTGAGAAGGTGATTGAAGAGCT TCGAAAGTTGCTCAACTTCTATGAGAAGCAGGAGGGCGAGAAGCTGCCGTTTCTGGGACTGGCTCTGAGCTCCCGCAAAAACTTGTGTAT TCACCCTGAGGCCAAGCTGATCGTCCCCAACAGCACGGCGGGCCTGATCATCGGCAAGGGAGGCGCCACGGTGAAAGCCGTGATGGAACA GTCAGGAGCATGGGTGCAGCTGTCCCAGAAGCCGGAGGGCATCAACCTGCAGGAGCGCGTGGTGACGGTCAGCGGCGAGCCCGAGCAGGT GCACAAGGCCGTGAGCGCCATCGTGCAGAAGGTACAAGAAGACCCCCAGAGCAGCAGCTGCCTCAACATCAGCTACGCCAACGTGGCAGG CCCCGTGGCCAACTCCAACCCCACCGGCTCTCCGTACGCCAGCCCCGCGGATGTGCTGCCAGCCGCGGCCGCAGCGTCGGCCGCCGCCGC CTCCGGCCTGCTGGGCCCCGCCGGGCTGGCTGGCGTGGGGGCCTTTCCCGCCGCGCTGCCCGCCTTCTCAGGCACCGACCTGCTGGCCAT CAGCACGGCGCTTAACACGCTGGCAAGTTACGGCTACAACACCAACTCCCTGGGCCTGGGCCTCAACTCGGCCGCAGCTTCCGGCGTCCT GGCCGCCGTGGCCGCCGGGGCCAACCCAGCAGCCGCCGCCGCCGCCAACCTCCTGGCATCCTACGCGGGCGAGGCCGGGGCCGGGCCAGC CGGAGGGGCCGCCCCGCCGCCGCCCCCGCCTCCCGGAGCCCTGGGGTCCTTTGCGTTGGCCGCAGCCGCCAACGGCTACCTCGGGGCCGG GGCGGGCGGCGGGGCGGGCGGAGGGGGCGGCCCGCTGGTGGCCGCTGCAGCCGCGGCCGGGGCGGCCGGGGGCTTCCTGACGGCGGAGAA GCTGGCGGCTGAGAGTGCCAAGGAGCTGGTGGAGATTGCGGTGCCTGAGAACCTGGTGGGAGCCATCCTGGGGAAGGGGGGCAAGACGTT GGTGGAGTACCAGGAGCTGACGGGCGCTCGCATCCAGATCTCCAAGAAGGGCGAGTTCCTGCCAGGCACGCGGAACCGGCGGGTCACCAT CACGGGCAGCCCCGCGGCCACGCAAGCCGCTCAATACCTCATCAGTCAGCGGGTCACCTACGAGCAGGGAGTGAGGGCCTCAAACCCCCA GAAAGTGGGATGAGGCCTGTGGTGTGTGCTCCCACCCTTTTCTCTCCTCCCATCTCCTCCTCTTCCCTCTCCTCCTCCCCCCCAACTCCT GACCTCAGCTTGGTGTAGTCCTGCTCCTCTTGGGATGGGGCTGGGGTAGGCCCGACTGCACCCTCCCCTTCTGGTAGTCATAGGCAGGAT TGAGTGACGGTTGGGAAGGGGGCTCAGAAGCCCCCTCCCCAGCCCGGAACTGACCCCTCCTTCCTCCCTCCCTGTGCTTGGCTGGGCCTG ACCCTTCCTGTCCCAGGGCCCAGGTCTGTGTGATATCTGTATATATTGCATTTTGTTGATTTTAATAGAAAACAAAGCGTTATTTTCTCT TTCTTTCCCTCCTTTTTTTTTTTTTTTTTTTTTTTGGTAAGGATTTTTTCCCCCTTTATAAGTTTTTGTTTCCATATGGGAGGAGGGGAG GGAGCCTCTGGGTCACCCAGAATGAGGGGCCTTCCCAAAACACAACACCCCACCTCTCTGCTTTCAGTTCTAGATCTGAGGGAAGCCATG GGAGTAGAGGTAGCAGAGGCGTCTGAGCTGAAATGGGGCATTTGGAGCAAGGACCCCAGAGTTCCCAGATCTTCTCAGCTACTCTCCTCC CACTGGAGCTGTCCCTCCTAGGTGGGAATGTTCACTCTTTTGTTGTCAGGTTGTATGGGGGGGCAGGGACAGTGCTGCTGGGAAGGATGC CAGCTCTGGGATTGGGCCAGTCCTGTGGGCAAGACTTGCAAGAGGCTGGATCAACTTGGTGTGGTATCTCTGATGGCTTAGAGTAATGGC AATGAGGGTCTCTGTTGTGATGTCACTGAGTACTTTCTGGGGTGCTTCTGGGCACCCCTTATGATGTCACAGGAAGCAGTTCCTCAGAGG TTACTTCCTGTGAACATAAGGGAGCAGGTACTTCCTGTGATGTCTCAATGAGTTCTTCCTTGAAGGTCACTTTGGTGATATCATGGGAAG GTGTACTTCCGGTGATGCCTAGAGGTCACGTCCTGTGATGTCATTAGGCTGAAGCATGTACTTCCTGTATTGGACAGTGACCAGTCTCTG ACCTGCCTTCTCCCTCCACACCCTTCTTTGGTGGGTGTTGGCCTGGGGGTCTTCCTAGGAAGAGAATAAGGCACGGGACTTGGATCCAAT CTGGAGGACTCTAACGGAAAAAAACCAATATTGTCAGGGTCATCTCCATTCAAACACGTCAAGTCTGCGAACTCGCCCTGGAGGGAGGGG TGGGAGATGGACCTAGTGCAAACTACTGTTAAAGACCTCCCTTCCCACCCCTGCCTTTTGTGTGCATGCCTGTGTCTGCGTGGCTTTGTT TCATTGAATCGGGTGAGCCAAGTGTGTGGTGGCTCTGTCAGGCCAGTATGGCCAGGTGTAGAGTTCAGTGAGCCATAGTAGGGTCCCTTG GGCCAGAATGCTTCGTGTGGTCTGATAGGTTAGATTGGTTTGGTGGCTTCCAGCAAGCTGGCATACTTCGGTGATGTCTGATGGATCAGA ATGTTTTGGTGTGCTCACCAGGGGCTCTGGAGAACTAGAATGTTCTGATGGAGTCTGACAAGCCAGGCGGCCTTGAGAGTTGGTTTAGGA GTGGCTCCCTGAGTGCTGTGGCTGTGGTCAGCTCTAAGGACCTGTTGGCAGACTGAGATTTCAGGGCCTGACAACCATGTAGACTAGGAT AGCTGAGACCTCCCTCTACCCCCACCCATCTCCCTCTCTTCCTTGGAGACCACCTCCACTTTCTCCAACCCAAAGCAGGGCGCCCAGTGC CCTGGTTCCATCATCAGCATCTCTGGGGGAGGGGCGCCCCATGCCCACCCTCTCCCCCATTTGTCCGCCTCCTAGGTCTTCCAAACCCTT TTCTTCTCTATGACTTTGGGGGAAATCCAGCCTCCTTGTCTCTCTCCTAAAAAAGGAGGGAAGAAAAGCCACAGAGACAATTCCTGCCCC TAAAGCCTAGGAGATCCCTCTCCCTTGCTAGAGAGCCACCCCCAAATCAAAATGTGAAAATCCCTAGAAAGCAATAGCCTTCGAGGTACC TTGCACTGAATTTCCCACCCCAGCCCTTCCACCCGATGGGAGGCTGTAACTTGGGCACTGGGGTGACTTTTTCCATGCCCTTGTCATCTC CAGGGTGGGAGGCAGGCCCCACTTCCCCTCCCCTATCCCCCACTTCCCATTGTTGTTGCCCCACCCCTAATCTCCAGACTGAACCCAGAT GGAGATCTGAGTGCCAAAACAATTCTTGATGTAACTTTGTACATATCTTCTACTACCGTTGGGGGCTCTTGGGGTTAGAGGTGGGGGCGG CTCTGTGGGCCATTGCTCCCCTCCACCTCTCAAAAGACCTTACAGTATTTCACAGTATCTCTACCCGCACGCGAGTATTACAGTATCTAG CTGGAATATCCCCCTACAGCCCCCCAGGACCCTATGAGGAAGGGAAGGAGCCAGGGAGAGTGAAGTAAGGTCTGGGACTGGGGAGGTGGG ATCTGAATGAACTCATTTGCATATCATTTGCATCCTCCGCTTGGCAGCCGCTTTCTACAAACTCATTCACTGGAGTCTGGGTCCCAATCA GCCGGGTCCAGGACTCCTCTCACACAGACACATCTCCGGAGGCTGGGCCTCCTGAAAAGTGTTTGCTTGGGGTGTCTGTGTAACAACCCC TCCCTATTCATATTTCTTGGGGACCCCCTACCCAGCCAGCCAGGGTGATCTGAAAGGTATACTTTGCTAGCTCAGTGAGCTAGTTCACTC ACCATGTTGGTGAGCAGAGAGCCACACCTTTCCCCATTTTACCTTGGGAAACTCACTCCACCATCTTTGCCATCTCTTGAAAGTCCCTTC TGCAATCTGACCTCAATCTTTTGTGCTGCAGTTTGTCCAGAGGGGACACAGATGTGGGGTCAGGGATGAGGATTATTGAAAAACCCATCA TCTCTTTTTTTTTCCCCGTCTCCCTATTAGCCAATCCGATCTCAGAGTCTCTGAGTGGCCTCCTTGCACCCTTCTCTTCAGCACCCAGTA GGTGCTTAATAAGTGTTTGCTGCATTGGATTATCTCCCTATTCCTTCTCATTTGCCCTCTAGCTTCCCATACCTTCTCCAAGTGTCTTCC TCCCTTTCTTTGTCTGGCTCCCTATGACTTTCTATTTTTTTTTCCTCCGTGTGGTTCCCATTGTTTTCTGTCCTGTCTCTATCTTAGTCT TTGTCTGTCTTCCTCCTTTCCTCAAATGTCTCAACTCTCTCTCCCCAATTTCCCCATTTAAAAAAAAAAAAAAGTGCCAAACTTCCTTGG AACTGAGCCGCTCTGGGGGGAGAGGACCTTGGATAGAGGGGAGGAAATGGGACCATTTCTCTTTGAGGAGGTCCCTAAGAGGCATTGCAA AAGTGTGGACATGGAGCTAAATTGGGTCCCCCTTCCACAGCCCTCCCACCCTGAGTTTTTCTTAGAATCTTTGTAAGAAAAAAAAAAAAA GACAGAAAAAAGCTCTCCTTTTCAACTTACCCCTATCCTTTTGGGTCCCCCCAAATTCCACCAGCCAAGGAGAATCCCACTTGCCAACTT CCTGGCAAATCTATGGAAACTGGGGAGGAGGAGACAAGCTCAACTCCTCCTCTGCTAGCCCAAGGGGCGGTACCAACTGGATTCAAGAGA AGGACCTCAAAGCTCCTATGAGAAGAGGGGGTTCGATGTGCCAAATTAACCTCCTTCATCCCCCATCTCAGGGGGCTCTGAGCCAACCTG CCCAGCCACCTTCTTCTGCCCTGTCCCAGCCACCTCTACATGGGCAAGGAGGCTTCACTGCAATAATTAGTAGGGGTGGTGATCAGAAGA CAATGATTTTGCCGTTTCTATCTGCCCTAACGCCTACCCTGGACTTGTAGTTGGGAATTATGGGTATCCCAAGTGGATGTTGATAAAAGC CGACCTATAGATGGTTGGGGACCTCTACTTGGAACACCAGGGTGTCGCTTATCTCCGAGGTGTATTTCCTCTCCCCTCTGGACCACCAAA TCCTTCAATATCCCCTCATTCTGTTTCTCCTCCCTGTTCCTCCATCCCACATCCTCCTTCTTACTTTGTTTTGATTGGTGGCCAATTGTT TGGAAAATGAGAGGAGTCCCCCTGAATGGATGATTGCTGTTTCAGGACCGGGATTAGAGGCTGTGATAGACTGTGCAGTGGCAAAAGTAT TAACAAGAGTGGCGATGAGGATGGCAGTTGGGGCGTCCAGGCTGCTGACTGAGTGCCCGCCTGTCGGTACAGCCAGCCAGGCCTTCGACA AGCACCTGCCTGGAAACCGGGCTCGCTGTCCTGAAAGCCTGGACTGGATGTCACGATGGGGAGAACGGGATCGCGATACCCAAGCTGGGG CACAGGCGAGCCAGGGACACTGGTTTACTGGGGTGATAACACCCAGCCCTGCTATCGCGATCCGTTTGCACTGTGGTCAGCTGTCTCCAC GCCGTGGTTGGAGAGGGCTTGTCTCCGGGCGCCACTGCTGGTGTGTATGGTCTGTCTTAGTGTCCCCTGCAAGTTGCATTGGAGATTGCT GGGTGGCAGGGAGGGAAATGGGAAGAGAATCTGTGGGGTCATGGTGGTGAAGGCTGCTGGTTTTTAATCCCTTCTCAACCAGTCCAGGAC ACTTGTCTCCCAGAGATAACTGGGGGGGGACTGCCTAACCCCCCCTCCCCCACCCCTTTCCCTACCCCACCTCTCCCCCCAAAACCACCA ACCTCTCATCTTCTAAGTGACTCCATCACCACCGGCCACCGGGACCTGCGGCCTCATTGCTCCAGCCCGCCCCACTCGACCGTCAGACTC GCTCATCGAACTCTTTTTGATTAACCCTTTCTGTGTTCATCCCACGGAAAACTGTGTGTCCGGCAGGGGGGAGGGGGGAGGCTAGGGGCA GTTGCTACCTTTCCTCCATCTCCTCCCACCACCCATGCCTCCCCACCCGCACCCCATCCCATGCCCCACCCCCATCCCTCACCCCTAGGG TCTGCCCCACCCTGGGGATTGACATCCTCTATAAATATCTATGCTATTTGGCTTTGTCCCTTTAAAAGGCGGGTCCAGGGGCGTGGCCTC CCTCAAATGGAGCGCTCACTCTGACCCCCTCCTTCGTGTGCCCCCCACACACTCCCCACGCCTTCATTGTAAATAGTCACTTTTGTACTG GGTTTGAGCCAGGGGACGTGGGGAGTCATTTTTCTTTTCTTTATGTTGGCATCTCAGGCCACTGGAGGCATGGCCCACATCCCGGGTCGA TTTGGGAGAATTTTAAGGTATGTCCCCTCACCTGTCCCCATCGCTAAGGATTTCAAGCTATCAGTATTACTCTAGAGGGATGGGGTGCAT AGATTCCCCGGCAGGGTGGTGGGAGAGGTGTGGAAAGGTGTAGTCTGGGAGGATGCCTCCGTTTTCCCCTTCTGTGAAATGGATTCATCC TCCAATTTCCCTGAGGAGCCTCAGTGAGATAATGGTGGAGTCAGAGGAGCTAGAACCTCTCTTCCCCCTTTCTCTGTTGGAGACAGGGTA GCAGAAGAATGGGGGACAGGGGAGGCTGCAGGGCCATCTTTGGAGAACCGATTGCTAAATCCTTCTTAGGACCTTAAGGTAGCCTCCTCT CCAGGCTTGTTCTCCCTCTTGGAATATGGGGAGGACTGGAGGACCTCTAAGGTCCCTTGGTTCTCCCCAGTCCTTAGATTAAAAGGCCCA GGCCCCAGGCTGGCCCCCTGCCTGCTGTCCCACTCCTTCATTCCATTTCTTGGAATGTGGCCATGCCTCCAGTGCCTCCATTCAACCCCC TCTAACTGATTCCTTCCATCCTCTGCGACCAGAGACGCCGCCCGCCTCCTGCCCACCACCTCCAGAAGCTCCTGGCTGGGGTGCACTGCC GTCTCCTCCCACTCCCCACATTGCCATGCCTGGGCCACGCCCACCCCACCCACTCACCCACCCCCAGTGTCCGTTGTGTGACCTAGTGCA CCATGTATTAGCTTCCATGGCCCCCACCCCAGCCCCCACCACACCCCCTTTCCCCACCCCTTTCCCCTCGGCGACTTCACCTTTTTTTGC >27309_27309_2_ERCC2-NOVA2_ERCC2_chr19_45871888_ENST00000391940_NOVA2_chr19_46444203_ENST00000263257_length(amino acids)=480AA_BP=120 MKLNVDGLLVYFPYDYIYPEQFSYMRELKRTLDAKGHGVLEMPSGTGKTVSLLALIMAYQRAYPLEVTKLIYCSRTVPEIEKVIEELRKL LNFYEKQEGEKLPFLGLALSSRKNLCIHPEAKLIVPNSTAGLIIGKGGATVKAVMEQSGAWVQLSQKPEGINLQERVVTVSGEPEQVHKA VSAIVQKVQEDPQSSSCLNISYANVAGPVANSNPTGSPYASPADVLPAAAAASAAAASGLLGPAGLAGVGAFPAALPAFSGTDLLAISTA LNTLASYGYNTNSLGLGLNSAAASGVLAAVAAGANPAAAAAANLLASYAGEAGAGPAGGAAPPPPPPPGALGSFALAAAANGYLGAGAGG GAGGGGGPLVAAAAAAGAAGGFLTAEKLAAESAKELVEIAVPENLVGAILGKGGKTLVEYQELTGARIQISKKGEFLPGTRNRRVTITGS -------------------------------------------------------------- >27309_27309_3_ERCC2-NOVA2_ERCC2_chr19_45871888_ENST00000391944_NOVA2_chr19_46444203_ENST00000263257_length(transcript)=7600nt_BP=388nt GACCCCGCTGCACAGTCCGGCCGGCGCCATGAAGCTCAACGTGGACGGGCTCCTGGTCTACTTCCCGTACGACTACATCTACCCCGAGCA GTTCTCCTACATGCGGGAGCTCAAACGCACGCTGGACGCCAAGGGTCATGGAGTCCTGGAGATGCCCTCAGGCACCGGGAAGACAGTATC CCTGTTGGCCCTGATCATGGCATACCAGAGAGCATATCCGCTGGAGGTGACCAAACTCATCTACTGCTCAAGAACTGTGCCAGAGATTGA GAAGGTGATTGAAGAGCTTCGAAAGTTGCTCAACTTCTATGAGAAGCAGGAGGGCGAGAAGCTGCCGTTTCTGGGACTGGCTCTGAGCTC CCGCAAAAACTTGTGTATTCACCCTGAGGCCAAGCTGATCGTCCCCAACAGCACGGCGGGCCTGATCATCGGCAAGGGAGGCGCCACGGT GAAAGCCGTGATGGAACAGTCAGGAGCATGGGTGCAGCTGTCCCAGAAGCCGGAGGGCATCAACCTGCAGGAGCGCGTGGTGACGGTCAG CGGCGAGCCCGAGCAGGTGCACAAGGCCGTGAGCGCCATCGTGCAGAAGGTACAAGAAGACCCCCAGAGCAGCAGCTGCCTCAACATCAG CTACGCCAACGTGGCAGGCCCCGTGGCCAACTCCAACCCCACCGGCTCTCCGTACGCCAGCCCCGCGGATGTGCTGCCAGCCGCGGCCGC AGCGTCGGCCGCCGCCGCCTCCGGCCTGCTGGGCCCCGCCGGGCTGGCTGGCGTGGGGGCCTTTCCCGCCGCGCTGCCCGCCTTCTCAGG CACCGACCTGCTGGCCATCAGCACGGCGCTTAACACGCTGGCAAGTTACGGCTACAACACCAACTCCCTGGGCCTGGGCCTCAACTCGGC CGCAGCTTCCGGCGTCCTGGCCGCCGTGGCCGCCGGGGCCAACCCAGCAGCCGCCGCCGCCGCCAACCTCCTGGCATCCTACGCGGGCGA GGCCGGGGCCGGGCCAGCCGGAGGGGCCGCCCCGCCGCCGCCCCCGCCTCCCGGAGCCCTGGGGTCCTTTGCGTTGGCCGCAGCCGCCAA CGGCTACCTCGGGGCCGGGGCGGGCGGCGGGGCGGGCGGAGGGGGCGGCCCGCTGGTGGCCGCTGCAGCCGCGGCCGGGGCGGCCGGGGG CTTCCTGACGGCGGAGAAGCTGGCGGCTGAGAGTGCCAAGGAGCTGGTGGAGATTGCGGTGCCTGAGAACCTGGTGGGAGCCATCCTGGG GAAGGGGGGCAAGACGTTGGTGGAGTACCAGGAGCTGACGGGCGCTCGCATCCAGATCTCCAAGAAGGGCGAGTTCCTGCCAGGCACGCG GAACCGGCGGGTCACCATCACGGGCAGCCCCGCGGCCACGCAAGCCGCTCAATACCTCATCAGTCAGCGGGTCACCTACGAGCAGGGAGT GAGGGCCTCAAACCCCCAGAAAGTGGGATGAGGCCTGTGGTGTGTGCTCCCACCCTTTTCTCTCCTCCCATCTCCTCCTCTTCCCTCTCC TCCTCCCCCCCAACTCCTGACCTCAGCTTGGTGTAGTCCTGCTCCTCTTGGGATGGGGCTGGGGTAGGCCCGACTGCACCCTCCCCTTCT GGTAGTCATAGGCAGGATTGAGTGACGGTTGGGAAGGGGGCTCAGAAGCCCCCTCCCCAGCCCGGAACTGACCCCTCCTTCCTCCCTCCC TGTGCTTGGCTGGGCCTGACCCTTCCTGTCCCAGGGCCCAGGTCTGTGTGATATCTGTATATATTGCATTTTGTTGATTTTAATAGAAAA CAAAGCGTTATTTTCTCTTTCTTTCCCTCCTTTTTTTTTTTTTTTTTTTTTTTGGTAAGGATTTTTTCCCCCTTTATAAGTTTTTGTTTC CATATGGGAGGAGGGGAGGGAGCCTCTGGGTCACCCAGAATGAGGGGCCTTCCCAAAACACAACACCCCACCTCTCTGCTTTCAGTTCTA GATCTGAGGGAAGCCATGGGAGTAGAGGTAGCAGAGGCGTCTGAGCTGAAATGGGGCATTTGGAGCAAGGACCCCAGAGTTCCCAGATCT TCTCAGCTACTCTCCTCCCACTGGAGCTGTCCCTCCTAGGTGGGAATGTTCACTCTTTTGTTGTCAGGTTGTATGGGGGGGCAGGGACAG TGCTGCTGGGAAGGATGCCAGCTCTGGGATTGGGCCAGTCCTGTGGGCAAGACTTGCAAGAGGCTGGATCAACTTGGTGTGGTATCTCTG ATGGCTTAGAGTAATGGCAATGAGGGTCTCTGTTGTGATGTCACTGAGTACTTTCTGGGGTGCTTCTGGGCACCCCTTATGATGTCACAG GAAGCAGTTCCTCAGAGGTTACTTCCTGTGAACATAAGGGAGCAGGTACTTCCTGTGATGTCTCAATGAGTTCTTCCTTGAAGGTCACTT TGGTGATATCATGGGAAGGTGTACTTCCGGTGATGCCTAGAGGTCACGTCCTGTGATGTCATTAGGCTGAAGCATGTACTTCCTGTATTG GACAGTGACCAGTCTCTGACCTGCCTTCTCCCTCCACACCCTTCTTTGGTGGGTGTTGGCCTGGGGGTCTTCCTAGGAAGAGAATAAGGC ACGGGACTTGGATCCAATCTGGAGGACTCTAACGGAAAAAAACCAATATTGTCAGGGTCATCTCCATTCAAACACGTCAAGTCTGCGAAC TCGCCCTGGAGGGAGGGGTGGGAGATGGACCTAGTGCAAACTACTGTTAAAGACCTCCCTTCCCACCCCTGCCTTTTGTGTGCATGCCTG TGTCTGCGTGGCTTTGTTTCATTGAATCGGGTGAGCCAAGTGTGTGGTGGCTCTGTCAGGCCAGTATGGCCAGGTGTAGAGTTCAGTGAG CCATAGTAGGGTCCCTTGGGCCAGAATGCTTCGTGTGGTCTGATAGGTTAGATTGGTTTGGTGGCTTCCAGCAAGCTGGCATACTTCGGT GATGTCTGATGGATCAGAATGTTTTGGTGTGCTCACCAGGGGCTCTGGAGAACTAGAATGTTCTGATGGAGTCTGACAAGCCAGGCGGCC TTGAGAGTTGGTTTAGGAGTGGCTCCCTGAGTGCTGTGGCTGTGGTCAGCTCTAAGGACCTGTTGGCAGACTGAGATTTCAGGGCCTGAC AACCATGTAGACTAGGATAGCTGAGACCTCCCTCTACCCCCACCCATCTCCCTCTCTTCCTTGGAGACCACCTCCACTTTCTCCAACCCA AAGCAGGGCGCCCAGTGCCCTGGTTCCATCATCAGCATCTCTGGGGGAGGGGCGCCCCATGCCCACCCTCTCCCCCATTTGTCCGCCTCC TAGGTCTTCCAAACCCTTTTCTTCTCTATGACTTTGGGGGAAATCCAGCCTCCTTGTCTCTCTCCTAAAAAAGGAGGGAAGAAAAGCCAC AGAGACAATTCCTGCCCCTAAAGCCTAGGAGATCCCTCTCCCTTGCTAGAGAGCCACCCCCAAATCAAAATGTGAAAATCCCTAGAAAGC AATAGCCTTCGAGGTACCTTGCACTGAATTTCCCACCCCAGCCCTTCCACCCGATGGGAGGCTGTAACTTGGGCACTGGGGTGACTTTTT CCATGCCCTTGTCATCTCCAGGGTGGGAGGCAGGCCCCACTTCCCCTCCCCTATCCCCCACTTCCCATTGTTGTTGCCCCACCCCTAATC TCCAGACTGAACCCAGATGGAGATCTGAGTGCCAAAACAATTCTTGATGTAACTTTGTACATATCTTCTACTACCGTTGGGGGCTCTTGG GGTTAGAGGTGGGGGCGGCTCTGTGGGCCATTGCTCCCCTCCACCTCTCAAAAGACCTTACAGTATTTCACAGTATCTCTACCCGCACGC GAGTATTACAGTATCTAGCTGGAATATCCCCCTACAGCCCCCCAGGACCCTATGAGGAAGGGAAGGAGCCAGGGAGAGTGAAGTAAGGTC TGGGACTGGGGAGGTGGGATCTGAATGAACTCATTTGCATATCATTTGCATCCTCCGCTTGGCAGCCGCTTTCTACAAACTCATTCACTG GAGTCTGGGTCCCAATCAGCCGGGTCCAGGACTCCTCTCACACAGACACATCTCCGGAGGCTGGGCCTCCTGAAAAGTGTTTGCTTGGGG TGTCTGTGTAACAACCCCTCCCTATTCATATTTCTTGGGGACCCCCTACCCAGCCAGCCAGGGTGATCTGAAAGGTATACTTTGCTAGCT CAGTGAGCTAGTTCACTCACCATGTTGGTGAGCAGAGAGCCACACCTTTCCCCATTTTACCTTGGGAAACTCACTCCACCATCTTTGCCA TCTCTTGAAAGTCCCTTCTGCAATCTGACCTCAATCTTTTGTGCTGCAGTTTGTCCAGAGGGGACACAGATGTGGGGTCAGGGATGAGGA TTATTGAAAAACCCATCATCTCTTTTTTTTTCCCCGTCTCCCTATTAGCCAATCCGATCTCAGAGTCTCTGAGTGGCCTCCTTGCACCCT TCTCTTCAGCACCCAGTAGGTGCTTAATAAGTGTTTGCTGCATTGGATTATCTCCCTATTCCTTCTCATTTGCCCTCTAGCTTCCCATAC CTTCTCCAAGTGTCTTCCTCCCTTTCTTTGTCTGGCTCCCTATGACTTTCTATTTTTTTTTCCTCCGTGTGGTTCCCATTGTTTTCTGTC CTGTCTCTATCTTAGTCTTTGTCTGTCTTCCTCCTTTCCTCAAATGTCTCAACTCTCTCTCCCCAATTTCCCCATTTAAAAAAAAAAAAA AGTGCCAAACTTCCTTGGAACTGAGCCGCTCTGGGGGGAGAGGACCTTGGATAGAGGGGAGGAAATGGGACCATTTCTCTTTGAGGAGGT CCCTAAGAGGCATTGCAAAAGTGTGGACATGGAGCTAAATTGGGTCCCCCTTCCACAGCCCTCCCACCCTGAGTTTTTCTTAGAATCTTT GTAAGAAAAAAAAAAAAAGACAGAAAAAAGCTCTCCTTTTCAACTTACCCCTATCCTTTTGGGTCCCCCCAAATTCCACCAGCCAAGGAG AATCCCACTTGCCAACTTCCTGGCAAATCTATGGAAACTGGGGAGGAGGAGACAAGCTCAACTCCTCCTCTGCTAGCCCAAGGGGCGGTA CCAACTGGATTCAAGAGAAGGACCTCAAAGCTCCTATGAGAAGAGGGGGTTCGATGTGCCAAATTAACCTCCTTCATCCCCCATCTCAGG GGGCTCTGAGCCAACCTGCCCAGCCACCTTCTTCTGCCCTGTCCCAGCCACCTCTACATGGGCAAGGAGGCTTCACTGCAATAATTAGTA GGGGTGGTGATCAGAAGACAATGATTTTGCCGTTTCTATCTGCCCTAACGCCTACCCTGGACTTGTAGTTGGGAATTATGGGTATCCCAA GTGGATGTTGATAAAAGCCGACCTATAGATGGTTGGGGACCTCTACTTGGAACACCAGGGTGTCGCTTATCTCCGAGGTGTATTTCCTCT CCCCTCTGGACCACCAAATCCTTCAATATCCCCTCATTCTGTTTCTCCTCCCTGTTCCTCCATCCCACATCCTCCTTCTTACTTTGTTTT GATTGGTGGCCAATTGTTTGGAAAATGAGAGGAGTCCCCCTGAATGGATGATTGCTGTTTCAGGACCGGGATTAGAGGCTGTGATAGACT GTGCAGTGGCAAAAGTATTAACAAGAGTGGCGATGAGGATGGCAGTTGGGGCGTCCAGGCTGCTGACTGAGTGCCCGCCTGTCGGTACAG CCAGCCAGGCCTTCGACAAGCACCTGCCTGGAAACCGGGCTCGCTGTCCTGAAAGCCTGGACTGGATGTCACGATGGGGAGAACGGGATC GCGATACCCAAGCTGGGGCACAGGCGAGCCAGGGACACTGGTTTACTGGGGTGATAACACCCAGCCCTGCTATCGCGATCCGTTTGCACT GTGGTCAGCTGTCTCCACGCCGTGGTTGGAGAGGGCTTGTCTCCGGGCGCCACTGCTGGTGTGTATGGTCTGTCTTAGTGTCCCCTGCAA GTTGCATTGGAGATTGCTGGGTGGCAGGGAGGGAAATGGGAAGAGAATCTGTGGGGTCATGGTGGTGAAGGCTGCTGGTTTTTAATCCCT TCTCAACCAGTCCAGGACACTTGTCTCCCAGAGATAACTGGGGGGGGACTGCCTAACCCCCCCTCCCCCACCCCTTTCCCTACCCCACCT CTCCCCCCAAAACCACCAACCTCTCATCTTCTAAGTGACTCCATCACCACCGGCCACCGGGACCTGCGGCCTCATTGCTCCAGCCCGCCC CACTCGACCGTCAGACTCGCTCATCGAACTCTTTTTGATTAACCCTTTCTGTGTTCATCCCACGGAAAACTGTGTGTCCGGCAGGGGGGA GGGGGGAGGCTAGGGGCAGTTGCTACCTTTCCTCCATCTCCTCCCACCACCCATGCCTCCCCACCCGCACCCCATCCCATGCCCCACCCC CATCCCTCACCCCTAGGGTCTGCCCCACCCTGGGGATTGACATCCTCTATAAATATCTATGCTATTTGGCTTTGTCCCTTTAAAAGGCGG GTCCAGGGGCGTGGCCTCCCTCAAATGGAGCGCTCACTCTGACCCCCTCCTTCGTGTGCCCCCCACACACTCCCCACGCCTTCATTGTAA ATAGTCACTTTTGTACTGGGTTTGAGCCAGGGGACGTGGGGAGTCATTTTTCTTTTCTTTATGTTGGCATCTCAGGCCACTGGAGGCATG GCCCACATCCCGGGTCGATTTGGGAGAATTTTAAGGTATGTCCCCTCACCTGTCCCCATCGCTAAGGATTTCAAGCTATCAGTATTACTC TAGAGGGATGGGGTGCATAGATTCCCCGGCAGGGTGGTGGGAGAGGTGTGGAAAGGTGTAGTCTGGGAGGATGCCTCCGTTTTCCCCTTC TGTGAAATGGATTCATCCTCCAATTTCCCTGAGGAGCCTCAGTGAGATAATGGTGGAGTCAGAGGAGCTAGAACCTCTCTTCCCCCTTTC TCTGTTGGAGACAGGGTAGCAGAAGAATGGGGGACAGGGGAGGCTGCAGGGCCATCTTTGGAGAACCGATTGCTAAATCCTTCTTAGGAC CTTAAGGTAGCCTCCTCTCCAGGCTTGTTCTCCCTCTTGGAATATGGGGAGGACTGGAGGACCTCTAAGGTCCCTTGGTTCTCCCCAGTC CTTAGATTAAAAGGCCCAGGCCCCAGGCTGGCCCCCTGCCTGCTGTCCCACTCCTTCATTCCATTTCTTGGAATGTGGCCATGCCTCCAG TGCCTCCATTCAACCCCCTCTAACTGATTCCTTCCATCCTCTGCGACCAGAGACGCCGCCCGCCTCCTGCCCACCACCTCCAGAAGCTCC TGGCTGGGGTGCACTGCCGTCTCCTCCCACTCCCCACATTGCCATGCCTGGGCCACGCCCACCCCACCCACTCACCCACCCCCAGTGTCC GTTGTGTGACCTAGTGCACCATGTATTAGCTTCCATGGCCCCCACCCCAGCCCCCACCACACCCCCTTTCCCCACCCCTTTCCCCTCGGC >27309_27309_3_ERCC2-NOVA2_ERCC2_chr19_45871888_ENST00000391944_NOVA2_chr19_46444203_ENST00000263257_length(amino acids)=487AA_BP=127 MHSPAGAMKLNVDGLLVYFPYDYIYPEQFSYMRELKRTLDAKGHGVLEMPSGTGKTVSLLALIMAYQRAYPLEVTKLIYCSRTVPEIEKV IEELRKLLNFYEKQEGEKLPFLGLALSSRKNLCIHPEAKLIVPNSTAGLIIGKGGATVKAVMEQSGAWVQLSQKPEGINLQERVVTVSGE PEQVHKAVSAIVQKVQEDPQSSSCLNISYANVAGPVANSNPTGSPYASPADVLPAAAAASAAAASGLLGPAGLAGVGAFPAALPAFSGTD LLAISTALNTLASYGYNTNSLGLGLNSAAASGVLAAVAAGANPAAAAAANLLASYAGEAGAGPAGGAAPPPPPPPGALGSFALAAAANGY LGAGAGGGAGGGGGPLVAAAAAAGAAGGFLTAEKLAAESAKELVEIAVPENLVGAILGKGGKTLVEYQELTGARIQISKKGEFLPGTRNR -------------------------------------------------------------- >27309_27309_4_ERCC2-NOVA2_ERCC2_chr19_45871888_ENST00000391945_NOVA2_chr19_46444203_ENST00000263257_length(transcript)=7650nt_BP=438nt GGATGTCCACGACCCGGCCTCTCGCTGAATATTCATGAGGGAGGCGGGTCGACCCCGCTGCACAGTCCGGCCGGCGCCATGAAGCTCAAC GTGGACGGGCTCCTGGTCTACTTCCCGTACGACTACATCTACCCCGAGCAGTTCTCCTACATGCGGGAGCTCAAACGCACGCTGGACGCC AAGGGTCATGGAGTCCTGGAGATGCCCTCAGGCACCGGGAAGACAGTATCCCTGTTGGCCCTGATCATGGCATACCAGAGAGCATATCCG CTGGAGGTGACCAAACTCATCTACTGCTCAAGAACTGTGCCAGAGATTGAGAAGGTGATTGAAGAGCTTCGAAAGTTGCTCAACTTCTAT GAGAAGCAGGAGGGCGAGAAGCTGCCGTTTCTGGGACTGGCTCTGAGCTCCCGCAAAAACTTGTGTATTCACCCTGAGGCCAAGCTGATC GTCCCCAACAGCACGGCGGGCCTGATCATCGGCAAGGGAGGCGCCACGGTGAAAGCCGTGATGGAACAGTCAGGAGCATGGGTGCAGCTG TCCCAGAAGCCGGAGGGCATCAACCTGCAGGAGCGCGTGGTGACGGTCAGCGGCGAGCCCGAGCAGGTGCACAAGGCCGTGAGCGCCATC GTGCAGAAGGTACAAGAAGACCCCCAGAGCAGCAGCTGCCTCAACATCAGCTACGCCAACGTGGCAGGCCCCGTGGCCAACTCCAACCCC ACCGGCTCTCCGTACGCCAGCCCCGCGGATGTGCTGCCAGCCGCGGCCGCAGCGTCGGCCGCCGCCGCCTCCGGCCTGCTGGGCCCCGCC GGGCTGGCTGGCGTGGGGGCCTTTCCCGCCGCGCTGCCCGCCTTCTCAGGCACCGACCTGCTGGCCATCAGCACGGCGCTTAACACGCTG GCAAGTTACGGCTACAACACCAACTCCCTGGGCCTGGGCCTCAACTCGGCCGCAGCTTCCGGCGTCCTGGCCGCCGTGGCCGCCGGGGCC AACCCAGCAGCCGCCGCCGCCGCCAACCTCCTGGCATCCTACGCGGGCGAGGCCGGGGCCGGGCCAGCCGGAGGGGCCGCCCCGCCGCCG CCCCCGCCTCCCGGAGCCCTGGGGTCCTTTGCGTTGGCCGCAGCCGCCAACGGCTACCTCGGGGCCGGGGCGGGCGGCGGGGCGGGCGGA GGGGGCGGCCCGCTGGTGGCCGCTGCAGCCGCGGCCGGGGCGGCCGGGGGCTTCCTGACGGCGGAGAAGCTGGCGGCTGAGAGTGCCAAG GAGCTGGTGGAGATTGCGGTGCCTGAGAACCTGGTGGGAGCCATCCTGGGGAAGGGGGGCAAGACGTTGGTGGAGTACCAGGAGCTGACG GGCGCTCGCATCCAGATCTCCAAGAAGGGCGAGTTCCTGCCAGGCACGCGGAACCGGCGGGTCACCATCACGGGCAGCCCCGCGGCCACG CAAGCCGCTCAATACCTCATCAGTCAGCGGGTCACCTACGAGCAGGGAGTGAGGGCCTCAAACCCCCAGAAAGTGGGATGAGGCCTGTGG TGTGTGCTCCCACCCTTTTCTCTCCTCCCATCTCCTCCTCTTCCCTCTCCTCCTCCCCCCCAACTCCTGACCTCAGCTTGGTGTAGTCCT GCTCCTCTTGGGATGGGGCTGGGGTAGGCCCGACTGCACCCTCCCCTTCTGGTAGTCATAGGCAGGATTGAGTGACGGTTGGGAAGGGGG CTCAGAAGCCCCCTCCCCAGCCCGGAACTGACCCCTCCTTCCTCCCTCCCTGTGCTTGGCTGGGCCTGACCCTTCCTGTCCCAGGGCCCA GGTCTGTGTGATATCTGTATATATTGCATTTTGTTGATTTTAATAGAAAACAAAGCGTTATTTTCTCTTTCTTTCCCTCCTTTTTTTTTT TTTTTTTTTTTTTGGTAAGGATTTTTTCCCCCTTTATAAGTTTTTGTTTCCATATGGGAGGAGGGGAGGGAGCCTCTGGGTCACCCAGAA TGAGGGGCCTTCCCAAAACACAACACCCCACCTCTCTGCTTTCAGTTCTAGATCTGAGGGAAGCCATGGGAGTAGAGGTAGCAGAGGCGT CTGAGCTGAAATGGGGCATTTGGAGCAAGGACCCCAGAGTTCCCAGATCTTCTCAGCTACTCTCCTCCCACTGGAGCTGTCCCTCCTAGG TGGGAATGTTCACTCTTTTGTTGTCAGGTTGTATGGGGGGGCAGGGACAGTGCTGCTGGGAAGGATGCCAGCTCTGGGATTGGGCCAGTC CTGTGGGCAAGACTTGCAAGAGGCTGGATCAACTTGGTGTGGTATCTCTGATGGCTTAGAGTAATGGCAATGAGGGTCTCTGTTGTGATG TCACTGAGTACTTTCTGGGGTGCTTCTGGGCACCCCTTATGATGTCACAGGAAGCAGTTCCTCAGAGGTTACTTCCTGTGAACATAAGGG AGCAGGTACTTCCTGTGATGTCTCAATGAGTTCTTCCTTGAAGGTCACTTTGGTGATATCATGGGAAGGTGTACTTCCGGTGATGCCTAG AGGTCACGTCCTGTGATGTCATTAGGCTGAAGCATGTACTTCCTGTATTGGACAGTGACCAGTCTCTGACCTGCCTTCTCCCTCCACACC CTTCTTTGGTGGGTGTTGGCCTGGGGGTCTTCCTAGGAAGAGAATAAGGCACGGGACTTGGATCCAATCTGGAGGACTCTAACGGAAAAA AACCAATATTGTCAGGGTCATCTCCATTCAAACACGTCAAGTCTGCGAACTCGCCCTGGAGGGAGGGGTGGGAGATGGACCTAGTGCAAA CTACTGTTAAAGACCTCCCTTCCCACCCCTGCCTTTTGTGTGCATGCCTGTGTCTGCGTGGCTTTGTTTCATTGAATCGGGTGAGCCAAG TGTGTGGTGGCTCTGTCAGGCCAGTATGGCCAGGTGTAGAGTTCAGTGAGCCATAGTAGGGTCCCTTGGGCCAGAATGCTTCGTGTGGTC TGATAGGTTAGATTGGTTTGGTGGCTTCCAGCAAGCTGGCATACTTCGGTGATGTCTGATGGATCAGAATGTTTTGGTGTGCTCACCAGG GGCTCTGGAGAACTAGAATGTTCTGATGGAGTCTGACAAGCCAGGCGGCCTTGAGAGTTGGTTTAGGAGTGGCTCCCTGAGTGCTGTGGC TGTGGTCAGCTCTAAGGACCTGTTGGCAGACTGAGATTTCAGGGCCTGACAACCATGTAGACTAGGATAGCTGAGACCTCCCTCTACCCC CACCCATCTCCCTCTCTTCCTTGGAGACCACCTCCACTTTCTCCAACCCAAAGCAGGGCGCCCAGTGCCCTGGTTCCATCATCAGCATCT CTGGGGGAGGGGCGCCCCATGCCCACCCTCTCCCCCATTTGTCCGCCTCCTAGGTCTTCCAAACCCTTTTCTTCTCTATGACTTTGGGGG AAATCCAGCCTCCTTGTCTCTCTCCTAAAAAAGGAGGGAAGAAAAGCCACAGAGACAATTCCTGCCCCTAAAGCCTAGGAGATCCCTCTC CCTTGCTAGAGAGCCACCCCCAAATCAAAATGTGAAAATCCCTAGAAAGCAATAGCCTTCGAGGTACCTTGCACTGAATTTCCCACCCCA GCCCTTCCACCCGATGGGAGGCTGTAACTTGGGCACTGGGGTGACTTTTTCCATGCCCTTGTCATCTCCAGGGTGGGAGGCAGGCCCCAC TTCCCCTCCCCTATCCCCCACTTCCCATTGTTGTTGCCCCACCCCTAATCTCCAGACTGAACCCAGATGGAGATCTGAGTGCCAAAACAA TTCTTGATGTAACTTTGTACATATCTTCTACTACCGTTGGGGGCTCTTGGGGTTAGAGGTGGGGGCGGCTCTGTGGGCCATTGCTCCCCT CCACCTCTCAAAAGACCTTACAGTATTTCACAGTATCTCTACCCGCACGCGAGTATTACAGTATCTAGCTGGAATATCCCCCTACAGCCC CCCAGGACCCTATGAGGAAGGGAAGGAGCCAGGGAGAGTGAAGTAAGGTCTGGGACTGGGGAGGTGGGATCTGAATGAACTCATTTGCAT ATCATTTGCATCCTCCGCTTGGCAGCCGCTTTCTACAAACTCATTCACTGGAGTCTGGGTCCCAATCAGCCGGGTCCAGGACTCCTCTCA CACAGACACATCTCCGGAGGCTGGGCCTCCTGAAAAGTGTTTGCTTGGGGTGTCTGTGTAACAACCCCTCCCTATTCATATTTCTTGGGG ACCCCCTACCCAGCCAGCCAGGGTGATCTGAAAGGTATACTTTGCTAGCTCAGTGAGCTAGTTCACTCACCATGTTGGTGAGCAGAGAGC CACACCTTTCCCCATTTTACCTTGGGAAACTCACTCCACCATCTTTGCCATCTCTTGAAAGTCCCTTCTGCAATCTGACCTCAATCTTTT GTGCTGCAGTTTGTCCAGAGGGGACACAGATGTGGGGTCAGGGATGAGGATTATTGAAAAACCCATCATCTCTTTTTTTTTCCCCGTCTC CCTATTAGCCAATCCGATCTCAGAGTCTCTGAGTGGCCTCCTTGCACCCTTCTCTTCAGCACCCAGTAGGTGCTTAATAAGTGTTTGCTG CATTGGATTATCTCCCTATTCCTTCTCATTTGCCCTCTAGCTTCCCATACCTTCTCCAAGTGTCTTCCTCCCTTTCTTTGTCTGGCTCCC TATGACTTTCTATTTTTTTTTCCTCCGTGTGGTTCCCATTGTTTTCTGTCCTGTCTCTATCTTAGTCTTTGTCTGTCTTCCTCCTTTCCT CAAATGTCTCAACTCTCTCTCCCCAATTTCCCCATTTAAAAAAAAAAAAAAGTGCCAAACTTCCTTGGAACTGAGCCGCTCTGGGGGGAG AGGACCTTGGATAGAGGGGAGGAAATGGGACCATTTCTCTTTGAGGAGGTCCCTAAGAGGCATTGCAAAAGTGTGGACATGGAGCTAAAT TGGGTCCCCCTTCCACAGCCCTCCCACCCTGAGTTTTTCTTAGAATCTTTGTAAGAAAAAAAAAAAAAGACAGAAAAAAGCTCTCCTTTT CAACTTACCCCTATCCTTTTGGGTCCCCCCAAATTCCACCAGCCAAGGAGAATCCCACTTGCCAACTTCCTGGCAAATCTATGGAAACTG GGGAGGAGGAGACAAGCTCAACTCCTCCTCTGCTAGCCCAAGGGGCGGTACCAACTGGATTCAAGAGAAGGACCTCAAAGCTCCTATGAG AAGAGGGGGTTCGATGTGCCAAATTAACCTCCTTCATCCCCCATCTCAGGGGGCTCTGAGCCAACCTGCCCAGCCACCTTCTTCTGCCCT GTCCCAGCCACCTCTACATGGGCAAGGAGGCTTCACTGCAATAATTAGTAGGGGTGGTGATCAGAAGACAATGATTTTGCCGTTTCTATC TGCCCTAACGCCTACCCTGGACTTGTAGTTGGGAATTATGGGTATCCCAAGTGGATGTTGATAAAAGCCGACCTATAGATGGTTGGGGAC CTCTACTTGGAACACCAGGGTGTCGCTTATCTCCGAGGTGTATTTCCTCTCCCCTCTGGACCACCAAATCCTTCAATATCCCCTCATTCT GTTTCTCCTCCCTGTTCCTCCATCCCACATCCTCCTTCTTACTTTGTTTTGATTGGTGGCCAATTGTTTGGAAAATGAGAGGAGTCCCCC TGAATGGATGATTGCTGTTTCAGGACCGGGATTAGAGGCTGTGATAGACTGTGCAGTGGCAAAAGTATTAACAAGAGTGGCGATGAGGAT GGCAGTTGGGGCGTCCAGGCTGCTGACTGAGTGCCCGCCTGTCGGTACAGCCAGCCAGGCCTTCGACAAGCACCTGCCTGGAAACCGGGC TCGCTGTCCTGAAAGCCTGGACTGGATGTCACGATGGGGAGAACGGGATCGCGATACCCAAGCTGGGGCACAGGCGAGCCAGGGACACTG GTTTACTGGGGTGATAACACCCAGCCCTGCTATCGCGATCCGTTTGCACTGTGGTCAGCTGTCTCCACGCCGTGGTTGGAGAGGGCTTGT CTCCGGGCGCCACTGCTGGTGTGTATGGTCTGTCTTAGTGTCCCCTGCAAGTTGCATTGGAGATTGCTGGGTGGCAGGGAGGGAAATGGG AAGAGAATCTGTGGGGTCATGGTGGTGAAGGCTGCTGGTTTTTAATCCCTTCTCAACCAGTCCAGGACACTTGTCTCCCAGAGATAACTG GGGGGGGACTGCCTAACCCCCCCTCCCCCACCCCTTTCCCTACCCCACCTCTCCCCCCAAAACCACCAACCTCTCATCTTCTAAGTGACT CCATCACCACCGGCCACCGGGACCTGCGGCCTCATTGCTCCAGCCCGCCCCACTCGACCGTCAGACTCGCTCATCGAACTCTTTTTGATT AACCCTTTCTGTGTTCATCCCACGGAAAACTGTGTGTCCGGCAGGGGGGAGGGGGGAGGCTAGGGGCAGTTGCTACCTTTCCTCCATCTC CTCCCACCACCCATGCCTCCCCACCCGCACCCCATCCCATGCCCCACCCCCATCCCTCACCCCTAGGGTCTGCCCCACCCTGGGGATTGA CATCCTCTATAAATATCTATGCTATTTGGCTTTGTCCCTTTAAAAGGCGGGTCCAGGGGCGTGGCCTCCCTCAAATGGAGCGCTCACTCT GACCCCCTCCTTCGTGTGCCCCCCACACACTCCCCACGCCTTCATTGTAAATAGTCACTTTTGTACTGGGTTTGAGCCAGGGGACGTGGG GAGTCATTTTTCTTTTCTTTATGTTGGCATCTCAGGCCACTGGAGGCATGGCCCACATCCCGGGTCGATTTGGGAGAATTTTAAGGTATG TCCCCTCACCTGTCCCCATCGCTAAGGATTTCAAGCTATCAGTATTACTCTAGAGGGATGGGGTGCATAGATTCCCCGGCAGGGTGGTGG GAGAGGTGTGGAAAGGTGTAGTCTGGGAGGATGCCTCCGTTTTCCCCTTCTGTGAAATGGATTCATCCTCCAATTTCCCTGAGGAGCCTC AGTGAGATAATGGTGGAGTCAGAGGAGCTAGAACCTCTCTTCCCCCTTTCTCTGTTGGAGACAGGGTAGCAGAAGAATGGGGGACAGGGG AGGCTGCAGGGCCATCTTTGGAGAACCGATTGCTAAATCCTTCTTAGGACCTTAAGGTAGCCTCCTCTCCAGGCTTGTTCTCCCTCTTGG AATATGGGGAGGACTGGAGGACCTCTAAGGTCCCTTGGTTCTCCCCAGTCCTTAGATTAAAAGGCCCAGGCCCCAGGCTGGCCCCCTGCC TGCTGTCCCACTCCTTCATTCCATTTCTTGGAATGTGGCCATGCCTCCAGTGCCTCCATTCAACCCCCTCTAACTGATTCCTTCCATCCT CTGCGACCAGAGACGCCGCCCGCCTCCTGCCCACCACCTCCAGAAGCTCCTGGCTGGGGTGCACTGCCGTCTCCTCCCACTCCCCACATT GCCATGCCTGGGCCACGCCCACCCCACCCACTCACCCACCCCCAGTGTCCGTTGTGTGACCTAGTGCACCATGTATTAGCTTCCATGGCC CCCACCCCAGCCCCCACCACACCCCCTTTCCCCACCCCTTTCCCCTCGGCGACTTCACCTTTTTTTGCCGCGATAAACGCCATCTCAGCA >27309_27309_4_ERCC2-NOVA2_ERCC2_chr19_45871888_ENST00000391945_NOVA2_chr19_46444203_ENST00000263257_length(amino acids)=498AA_BP=138 MNIHEGGGSTPLHSPAGAMKLNVDGLLVYFPYDYIYPEQFSYMRELKRTLDAKGHGVLEMPSGTGKTVSLLALIMAYQRAYPLEVTKLIY CSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKNLCIHPEAKLIVPNSTAGLIIGKGGATVKAVMEQSGAWVQLSQKPEGIN LQERVVTVSGEPEQVHKAVSAIVQKVQEDPQSSSCLNISYANVAGPVANSNPTGSPYASPADVLPAAAAASAAAASGLLGPAGLAGVGAF PAALPAFSGTDLLAISTALNTLASYGYNTNSLGLGLNSAAASGVLAAVAAGANPAAAAAANLLASYAGEAGAGPAGGAAPPPPPPPGALG SFALAAAANGYLGAGAGGGAGGGGGPLVAAAAAAGAAGGFLTAEKLAAESAKELVEIAVPENLVGAILGKGGKTLVEYQELTGARIQISK -------------------------------------------------------------- >27309_27309_5_ERCC2-NOVA2_ERCC2_chr19_45871888_ENST00000485403_NOVA2_chr19_46444203_ENST00000263257_length(transcript)=7719nt_BP=507nt GAGACACTGAGGGGGCCCCGAGGCTCCTGAGGACCTGAGGGTTACCGGGGGCGCCGGGCCCGTCACCCTTCTCTGGGCTCGACGACCGGG CACTGTGGAGGCGGGAGAGGGGCTGAGGGGACGGGAACTGACCCAGCAGCCCCTGCCGCCAGGCTCAACGTGGACGGGCTCCTGGTCTAC TTCCCGTACGACTACATCTACCCCGAGCAGTTCTCCTACATGCGGGAGCTCAAACGCACGCTGGACGCCAAGGGTCATGGAGTCCTGGAG ATGCCCTCAGGCACCGGGAAGACAGTATCCCTGTTGGCCCTGATCATGGCATACCAGAGAGCATATCCGCTGGAGGTGACCAAACTCATC TACTGCTCAAGAACTGTGCCAGAGATTGAGAAGGTGATTGAAGAGCTTCGAAAGTTGCTCAACTTCTATGAGAAGCAGGAGGGCGAGAAG CTGCCGTTTCTGGGACTGGCTCTGAGCTCCCGCAAAAACTTGTGTATTCACCCTGAGGCCAAGCTGATCGTCCCCAACAGCACGGCGGGC CTGATCATCGGCAAGGGAGGCGCCACGGTGAAAGCCGTGATGGAACAGTCAGGAGCATGGGTGCAGCTGTCCCAGAAGCCGGAGGGCATC AACCTGCAGGAGCGCGTGGTGACGGTCAGCGGCGAGCCCGAGCAGGTGCACAAGGCCGTGAGCGCCATCGTGCAGAAGGTACAAGAAGAC CCCCAGAGCAGCAGCTGCCTCAACATCAGCTACGCCAACGTGGCAGGCCCCGTGGCCAACTCCAACCCCACCGGCTCTCCGTACGCCAGC CCCGCGGATGTGCTGCCAGCCGCGGCCGCAGCGTCGGCCGCCGCCGCCTCCGGCCTGCTGGGCCCCGCCGGGCTGGCTGGCGTGGGGGCC TTTCCCGCCGCGCTGCCCGCCTTCTCAGGCACCGACCTGCTGGCCATCAGCACGGCGCTTAACACGCTGGCAAGTTACGGCTACAACACC AACTCCCTGGGCCTGGGCCTCAACTCGGCCGCAGCTTCCGGCGTCCTGGCCGCCGTGGCCGCCGGGGCCAACCCAGCAGCCGCCGCCGCC GCCAACCTCCTGGCATCCTACGCGGGCGAGGCCGGGGCCGGGCCAGCCGGAGGGGCCGCCCCGCCGCCGCCCCCGCCTCCCGGAGCCCTG GGGTCCTTTGCGTTGGCCGCAGCCGCCAACGGCTACCTCGGGGCCGGGGCGGGCGGCGGGGCGGGCGGAGGGGGCGGCCCGCTGGTGGCC GCTGCAGCCGCGGCCGGGGCGGCCGGGGGCTTCCTGACGGCGGAGAAGCTGGCGGCTGAGAGTGCCAAGGAGCTGGTGGAGATTGCGGTG CCTGAGAACCTGGTGGGAGCCATCCTGGGGAAGGGGGGCAAGACGTTGGTGGAGTACCAGGAGCTGACGGGCGCTCGCATCCAGATCTCC AAGAAGGGCGAGTTCCTGCCAGGCACGCGGAACCGGCGGGTCACCATCACGGGCAGCCCCGCGGCCACGCAAGCCGCTCAATACCTCATC AGTCAGCGGGTCACCTACGAGCAGGGAGTGAGGGCCTCAAACCCCCAGAAAGTGGGATGAGGCCTGTGGTGTGTGCTCCCACCCTTTTCT CTCCTCCCATCTCCTCCTCTTCCCTCTCCTCCTCCCCCCCAACTCCTGACCTCAGCTTGGTGTAGTCCTGCTCCTCTTGGGATGGGGCTG GGGTAGGCCCGACTGCACCCTCCCCTTCTGGTAGTCATAGGCAGGATTGAGTGACGGTTGGGAAGGGGGCTCAGAAGCCCCCTCCCCAGC CCGGAACTGACCCCTCCTTCCTCCCTCCCTGTGCTTGGCTGGGCCTGACCCTTCCTGTCCCAGGGCCCAGGTCTGTGTGATATCTGTATA TATTGCATTTTGTTGATTTTAATAGAAAACAAAGCGTTATTTTCTCTTTCTTTCCCTCCTTTTTTTTTTTTTTTTTTTTTTTGGTAAGGA TTTTTTCCCCCTTTATAAGTTTTTGTTTCCATATGGGAGGAGGGGAGGGAGCCTCTGGGTCACCCAGAATGAGGGGCCTTCCCAAAACAC AACACCCCACCTCTCTGCTTTCAGTTCTAGATCTGAGGGAAGCCATGGGAGTAGAGGTAGCAGAGGCGTCTGAGCTGAAATGGGGCATTT GGAGCAAGGACCCCAGAGTTCCCAGATCTTCTCAGCTACTCTCCTCCCACTGGAGCTGTCCCTCCTAGGTGGGAATGTTCACTCTTTTGT TGTCAGGTTGTATGGGGGGGCAGGGACAGTGCTGCTGGGAAGGATGCCAGCTCTGGGATTGGGCCAGTCCTGTGGGCAAGACTTGCAAGA GGCTGGATCAACTTGGTGTGGTATCTCTGATGGCTTAGAGTAATGGCAATGAGGGTCTCTGTTGTGATGTCACTGAGTACTTTCTGGGGT GCTTCTGGGCACCCCTTATGATGTCACAGGAAGCAGTTCCTCAGAGGTTACTTCCTGTGAACATAAGGGAGCAGGTACTTCCTGTGATGT CTCAATGAGTTCTTCCTTGAAGGTCACTTTGGTGATATCATGGGAAGGTGTACTTCCGGTGATGCCTAGAGGTCACGTCCTGTGATGTCA TTAGGCTGAAGCATGTACTTCCTGTATTGGACAGTGACCAGTCTCTGACCTGCCTTCTCCCTCCACACCCTTCTTTGGTGGGTGTTGGCC TGGGGGTCTTCCTAGGAAGAGAATAAGGCACGGGACTTGGATCCAATCTGGAGGACTCTAACGGAAAAAAACCAATATTGTCAGGGTCAT CTCCATTCAAACACGTCAAGTCTGCGAACTCGCCCTGGAGGGAGGGGTGGGAGATGGACCTAGTGCAAACTACTGTTAAAGACCTCCCTT CCCACCCCTGCCTTTTGTGTGCATGCCTGTGTCTGCGTGGCTTTGTTTCATTGAATCGGGTGAGCCAAGTGTGTGGTGGCTCTGTCAGGC CAGTATGGCCAGGTGTAGAGTTCAGTGAGCCATAGTAGGGTCCCTTGGGCCAGAATGCTTCGTGTGGTCTGATAGGTTAGATTGGTTTGG TGGCTTCCAGCAAGCTGGCATACTTCGGTGATGTCTGATGGATCAGAATGTTTTGGTGTGCTCACCAGGGGCTCTGGAGAACTAGAATGT TCTGATGGAGTCTGACAAGCCAGGCGGCCTTGAGAGTTGGTTTAGGAGTGGCTCCCTGAGTGCTGTGGCTGTGGTCAGCTCTAAGGACCT GTTGGCAGACTGAGATTTCAGGGCCTGACAACCATGTAGACTAGGATAGCTGAGACCTCCCTCTACCCCCACCCATCTCCCTCTCTTCCT TGGAGACCACCTCCACTTTCTCCAACCCAAAGCAGGGCGCCCAGTGCCCTGGTTCCATCATCAGCATCTCTGGGGGAGGGGCGCCCCATG CCCACCCTCTCCCCCATTTGTCCGCCTCCTAGGTCTTCCAAACCCTTTTCTTCTCTATGACTTTGGGGGAAATCCAGCCTCCTTGTCTCT CTCCTAAAAAAGGAGGGAAGAAAAGCCACAGAGACAATTCCTGCCCCTAAAGCCTAGGAGATCCCTCTCCCTTGCTAGAGAGCCACCCCC AAATCAAAATGTGAAAATCCCTAGAAAGCAATAGCCTTCGAGGTACCTTGCACTGAATTTCCCACCCCAGCCCTTCCACCCGATGGGAGG CTGTAACTTGGGCACTGGGGTGACTTTTTCCATGCCCTTGTCATCTCCAGGGTGGGAGGCAGGCCCCACTTCCCCTCCCCTATCCCCCAC TTCCCATTGTTGTTGCCCCACCCCTAATCTCCAGACTGAACCCAGATGGAGATCTGAGTGCCAAAACAATTCTTGATGTAACTTTGTACA TATCTTCTACTACCGTTGGGGGCTCTTGGGGTTAGAGGTGGGGGCGGCTCTGTGGGCCATTGCTCCCCTCCACCTCTCAAAAGACCTTAC AGTATTTCACAGTATCTCTACCCGCACGCGAGTATTACAGTATCTAGCTGGAATATCCCCCTACAGCCCCCCAGGACCCTATGAGGAAGG GAAGGAGCCAGGGAGAGTGAAGTAAGGTCTGGGACTGGGGAGGTGGGATCTGAATGAACTCATTTGCATATCATTTGCATCCTCCGCTTG GCAGCCGCTTTCTACAAACTCATTCACTGGAGTCTGGGTCCCAATCAGCCGGGTCCAGGACTCCTCTCACACAGACACATCTCCGGAGGC TGGGCCTCCTGAAAAGTGTTTGCTTGGGGTGTCTGTGTAACAACCCCTCCCTATTCATATTTCTTGGGGACCCCCTACCCAGCCAGCCAG GGTGATCTGAAAGGTATACTTTGCTAGCTCAGTGAGCTAGTTCACTCACCATGTTGGTGAGCAGAGAGCCACACCTTTCCCCATTTTACC TTGGGAAACTCACTCCACCATCTTTGCCATCTCTTGAAAGTCCCTTCTGCAATCTGACCTCAATCTTTTGTGCTGCAGTTTGTCCAGAGG GGACACAGATGTGGGGTCAGGGATGAGGATTATTGAAAAACCCATCATCTCTTTTTTTTTCCCCGTCTCCCTATTAGCCAATCCGATCTC AGAGTCTCTGAGTGGCCTCCTTGCACCCTTCTCTTCAGCACCCAGTAGGTGCTTAATAAGTGTTTGCTGCATTGGATTATCTCCCTATTC CTTCTCATTTGCCCTCTAGCTTCCCATACCTTCTCCAAGTGTCTTCCTCCCTTTCTTTGTCTGGCTCCCTATGACTTTCTATTTTTTTTT CCTCCGTGTGGTTCCCATTGTTTTCTGTCCTGTCTCTATCTTAGTCTTTGTCTGTCTTCCTCCTTTCCTCAAATGTCTCAACTCTCTCTC CCCAATTTCCCCATTTAAAAAAAAAAAAAAGTGCCAAACTTCCTTGGAACTGAGCCGCTCTGGGGGGAGAGGACCTTGGATAGAGGGGAG GAAATGGGACCATTTCTCTTTGAGGAGGTCCCTAAGAGGCATTGCAAAAGTGTGGACATGGAGCTAAATTGGGTCCCCCTTCCACAGCCC TCCCACCCTGAGTTTTTCTTAGAATCTTTGTAAGAAAAAAAAAAAAAGACAGAAAAAAGCTCTCCTTTTCAACTTACCCCTATCCTTTTG GGTCCCCCCAAATTCCACCAGCCAAGGAGAATCCCACTTGCCAACTTCCTGGCAAATCTATGGAAACTGGGGAGGAGGAGACAAGCTCAA CTCCTCCTCTGCTAGCCCAAGGGGCGGTACCAACTGGATTCAAGAGAAGGACCTCAAAGCTCCTATGAGAAGAGGGGGTTCGATGTGCCA AATTAACCTCCTTCATCCCCCATCTCAGGGGGCTCTGAGCCAACCTGCCCAGCCACCTTCTTCTGCCCTGTCCCAGCCACCTCTACATGG GCAAGGAGGCTTCACTGCAATAATTAGTAGGGGTGGTGATCAGAAGACAATGATTTTGCCGTTTCTATCTGCCCTAACGCCTACCCTGGA CTTGTAGTTGGGAATTATGGGTATCCCAAGTGGATGTTGATAAAAGCCGACCTATAGATGGTTGGGGACCTCTACTTGGAACACCAGGGT GTCGCTTATCTCCGAGGTGTATTTCCTCTCCCCTCTGGACCACCAAATCCTTCAATATCCCCTCATTCTGTTTCTCCTCCCTGTTCCTCC ATCCCACATCCTCCTTCTTACTTTGTTTTGATTGGTGGCCAATTGTTTGGAAAATGAGAGGAGTCCCCCTGAATGGATGATTGCTGTTTC AGGACCGGGATTAGAGGCTGTGATAGACTGTGCAGTGGCAAAAGTATTAACAAGAGTGGCGATGAGGATGGCAGTTGGGGCGTCCAGGCT GCTGACTGAGTGCCCGCCTGTCGGTACAGCCAGCCAGGCCTTCGACAAGCACCTGCCTGGAAACCGGGCTCGCTGTCCTGAAAGCCTGGA CTGGATGTCACGATGGGGAGAACGGGATCGCGATACCCAAGCTGGGGCACAGGCGAGCCAGGGACACTGGTTTACTGGGGTGATAACACC CAGCCCTGCTATCGCGATCCGTTTGCACTGTGGTCAGCTGTCTCCACGCCGTGGTTGGAGAGGGCTTGTCTCCGGGCGCCACTGCTGGTG TGTATGGTCTGTCTTAGTGTCCCCTGCAAGTTGCATTGGAGATTGCTGGGTGGCAGGGAGGGAAATGGGAAGAGAATCTGTGGGGTCATG GTGGTGAAGGCTGCTGGTTTTTAATCCCTTCTCAACCAGTCCAGGACACTTGTCTCCCAGAGATAACTGGGGGGGGACTGCCTAACCCCC CCTCCCCCACCCCTTTCCCTACCCCACCTCTCCCCCCAAAACCACCAACCTCTCATCTTCTAAGTGACTCCATCACCACCGGCCACCGGG ACCTGCGGCCTCATTGCTCCAGCCCGCCCCACTCGACCGTCAGACTCGCTCATCGAACTCTTTTTGATTAACCCTTTCTGTGTTCATCCC ACGGAAAACTGTGTGTCCGGCAGGGGGGAGGGGGGAGGCTAGGGGCAGTTGCTACCTTTCCTCCATCTCCTCCCACCACCCATGCCTCCC CACCCGCACCCCATCCCATGCCCCACCCCCATCCCTCACCCCTAGGGTCTGCCCCACCCTGGGGATTGACATCCTCTATAAATATCTATG CTATTTGGCTTTGTCCCTTTAAAAGGCGGGTCCAGGGGCGTGGCCTCCCTCAAATGGAGCGCTCACTCTGACCCCCTCCTTCGTGTGCCC CCCACACACTCCCCACGCCTTCATTGTAAATAGTCACTTTTGTACTGGGTTTGAGCCAGGGGACGTGGGGAGTCATTTTTCTTTTCTTTA TGTTGGCATCTCAGGCCACTGGAGGCATGGCCCACATCCCGGGTCGATTTGGGAGAATTTTAAGGTATGTCCCCTCACCTGTCCCCATCG CTAAGGATTTCAAGCTATCAGTATTACTCTAGAGGGATGGGGTGCATAGATTCCCCGGCAGGGTGGTGGGAGAGGTGTGGAAAGGTGTAG TCTGGGAGGATGCCTCCGTTTTCCCCTTCTGTGAAATGGATTCATCCTCCAATTTCCCTGAGGAGCCTCAGTGAGATAATGGTGGAGTCA GAGGAGCTAGAACCTCTCTTCCCCCTTTCTCTGTTGGAGACAGGGTAGCAGAAGAATGGGGGACAGGGGAGGCTGCAGGGCCATCTTTGG AGAACCGATTGCTAAATCCTTCTTAGGACCTTAAGGTAGCCTCCTCTCCAGGCTTGTTCTCCCTCTTGGAATATGGGGAGGACTGGAGGA CCTCTAAGGTCCCTTGGTTCTCCCCAGTCCTTAGATTAAAAGGCCCAGGCCCCAGGCTGGCCCCCTGCCTGCTGTCCCACTCCTTCATTC CATTTCTTGGAATGTGGCCATGCCTCCAGTGCCTCCATTCAACCCCCTCTAACTGATTCCTTCCATCCTCTGCGACCAGAGACGCCGCCC GCCTCCTGCCCACCACCTCCAGAAGCTCCTGGCTGGGGTGCACTGCCGTCTCCTCCCACTCCCCACATTGCCATGCCTGGGCCACGCCCA CCCCACCCACTCACCCACCCCCAGTGTCCGTTGTGTGACCTAGTGCACCATGTATTAGCTTCCATGGCCCCCACCCCAGCCCCCACCACA >27309_27309_5_ERCC2-NOVA2_ERCC2_chr19_45871888_ENST00000485403_NOVA2_chr19_46444203_ENST00000263257_length(amino acids)=505AA_BP=145 MGSTTGHCGGGRGAEGTGTDPAAPAARLNVDGLLVYFPYDYIYPEQFSYMRELKRTLDAKGHGVLEMPSGTGKTVSLLALIMAYQRAYPL EVTKLIYCSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKNLCIHPEAKLIVPNSTAGLIIGKGGATVKAVMEQSGAWVQLS QKPEGINLQERVVTVSGEPEQVHKAVSAIVQKVQEDPQSSSCLNISYANVAGPVANSNPTGSPYASPADVLPAAAAASAAAASGLLGPAG LAGVGAFPAALPAFSGTDLLAISTALNTLASYGYNTNSLGLGLNSAAASGVLAAVAAGANPAAAAAANLLASYAGEAGAGPAGGAAPPPP PPPGALGSFALAAAANGYLGAGAGGGAGGGGGPLVAAAAAAGAAGGFLTAEKLAAESAKELVEIAVPENLVGAILGKGGKTLVEYQELTG -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for ERCC2-NOVA2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ERCC2-NOVA2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for ERCC2-NOVA2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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