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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ERCC6L2-CDC14B (FusionGDB2 ID:27319)

Fusion Gene Summary for ERCC6L2-CDC14B

check button Fusion gene summary
Fusion gene informationFusion gene name: ERCC6L2-CDC14B
Fusion gene ID: 27319
HgeneTgene
Gene symbol

ERCC6L2

CDC14B

Gene ID

375748

195828

Gene nameERCC excision repair 6 like 2zinc finger protein 367
SynonymsBMFS2|C9orf102|HEBO|RAD26L|SR278AFF29|CDC14B|ZFF29
Cytomap

9q22.32

9q22.32|9q22.32

Type of geneprotein-codingprotein-coding
DescriptionDNA excision repair protein ERCC-6-like 2DNA repair and recombination protein RAD26-likeexcision repair cross-complementation group 6 like 2excision repair cross-complementing rodent repair deficiency, complementation group 6-like 2putative repair andzinc finger protein 367C2H2 zinc finger protein ZFF29C2H2 zinc finger protein ZFF29aCDC14 cell division cycle 14 homolog B
Modification date2020031320200313
UniProtAcc

Q5T890

O60729

Ensembl transtripts involved in fusion geneENST00000407474, ENST00000288985, 
ENST00000437817, ENST00000466840, 
ENST00000481149, ENST00000265659, 
ENST00000375236, ENST00000375240, 
ENST00000375241, ENST00000375242, 
ENST00000463569, 
Fusion gene scores* DoF score8 X 8 X 6=3847 X 7 X 4=196
# samples 88
** MAII scorelog2(8/384*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/196*10)=-1.29278174922785
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ERCC6L2 [Title/Abstract] AND CDC14B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointERCC6L2(98766983)-CDC14B(99304174), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCDC14B

GO:0006357

regulation of transcription by RNA polymerase II

15344908


check buttonFusion gene breakpoints across ERCC6L2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CDC14B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-3B-A9HV-01AERCC6L2chr9

98766983

+CDC14Bchr9

99304174

-


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Fusion Gene ORF analysis for ERCC6L2-CDC14B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000407474ENST00000481149ERCC6L2chr9

98766983

+CDC14Bchr9

99304174

-
In-frameENST00000407474ENST00000265659ERCC6L2chr9

98766983

+CDC14Bchr9

99304174

-
In-frameENST00000407474ENST00000375236ERCC6L2chr9

98766983

+CDC14Bchr9

99304174

-
In-frameENST00000407474ENST00000375240ERCC6L2chr9

98766983

+CDC14Bchr9

99304174

-
In-frameENST00000407474ENST00000375241ERCC6L2chr9

98766983

+CDC14Bchr9

99304174

-
In-frameENST00000407474ENST00000375242ERCC6L2chr9

98766983

+CDC14Bchr9

99304174

-
In-frameENST00000407474ENST00000463569ERCC6L2chr9

98766983

+CDC14Bchr9

99304174

-
intron-3CDSENST00000288985ENST00000265659ERCC6L2chr9

98766983

+CDC14Bchr9

99304174

-
intron-3CDSENST00000288985ENST00000375236ERCC6L2chr9

98766983

+CDC14Bchr9

99304174

-
intron-3CDSENST00000288985ENST00000375240ERCC6L2chr9

98766983

+CDC14Bchr9

99304174

-
intron-3CDSENST00000288985ENST00000375241ERCC6L2chr9

98766983

+CDC14Bchr9

99304174

-
intron-3CDSENST00000288985ENST00000375242ERCC6L2chr9

98766983

+CDC14Bchr9

99304174

-
intron-3CDSENST00000288985ENST00000463569ERCC6L2chr9

98766983

+CDC14Bchr9

99304174

-
intron-3CDSENST00000437817ENST00000265659ERCC6L2chr9

98766983

+CDC14Bchr9

99304174

-
intron-3CDSENST00000437817ENST00000375236ERCC6L2chr9

98766983

+CDC14Bchr9

99304174

-
intron-3CDSENST00000437817ENST00000375240ERCC6L2chr9

98766983

+CDC14Bchr9

99304174

-
intron-3CDSENST00000437817ENST00000375241ERCC6L2chr9

98766983

+CDC14Bchr9

99304174

-
intron-3CDSENST00000437817ENST00000375242ERCC6L2chr9

98766983

+CDC14Bchr9

99304174

-
intron-3CDSENST00000437817ENST00000463569ERCC6L2chr9

98766983

+CDC14Bchr9

99304174

-
intron-3CDSENST00000466840ENST00000265659ERCC6L2chr9

98766983

+CDC14Bchr9

99304174

-
intron-3CDSENST00000466840ENST00000375236ERCC6L2chr9

98766983

+CDC14Bchr9

99304174

-
intron-3CDSENST00000466840ENST00000375240ERCC6L2chr9

98766983

+CDC14Bchr9

99304174

-
intron-3CDSENST00000466840ENST00000375241ERCC6L2chr9

98766983

+CDC14Bchr9

99304174

-
intron-3CDSENST00000466840ENST00000375242ERCC6L2chr9

98766983

+CDC14Bchr9

99304174

-
intron-3CDSENST00000466840ENST00000463569ERCC6L2chr9

98766983

+CDC14Bchr9

99304174

-
intron-intronENST00000288985ENST00000481149ERCC6L2chr9

98766983

+CDC14Bchr9

99304174

-
intron-intronENST00000437817ENST00000481149ERCC6L2chr9

98766983

+CDC14Bchr9

99304174

-
intron-intronENST00000466840ENST00000481149ERCC6L2chr9

98766983

+CDC14Bchr9

99304174

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000407474ERCC6L2chr998766983+ENST00000265659CDC14Bchr999304174-204911302282048606
ENST00000407474ERCC6L2chr998766983+ENST00000375241CDC14Bchr999304174-577011302282129633
ENST00000407474ERCC6L2chr998766983+ENST00000375240CDC14Bchr999304174-318011302282012594
ENST00000407474ERCC6L2chr998766983+ENST00000463569CDC14Bchr999304174-234511302282090620
ENST00000407474ERCC6L2chr998766983+ENST00000375236CDC14Bchr999304174-209111302282090620
ENST00000407474ERCC6L2chr998766983+ENST00000375242CDC14Bchr999304174-327111302282129633

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000407474ENST00000265659ERCC6L2chr998766983+CDC14Bchr999304174-0.0024960430.99750394
ENST00000407474ENST00000375241ERCC6L2chr998766983+CDC14Bchr999304174-0.0004119470.9995881
ENST00000407474ENST00000375240ERCC6L2chr998766983+CDC14Bchr999304174-0.000754220.99924576
ENST00000407474ENST00000463569ERCC6L2chr998766983+CDC14Bchr999304174-0.0019707270.9980293
ENST00000407474ENST00000375236ERCC6L2chr998766983+CDC14Bchr999304174-0.0019181540.9980818
ENST00000407474ENST00000375242ERCC6L2chr998766983+CDC14Bchr999304174-0.000960960.99903905

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Fusion Genomic Features for ERCC6L2-CDC14B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ERCC6L2-CDC14B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:98766983/chr9:99304174)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ERCC6L2

Q5T890

CDC14B

O60729

FUNCTION: May be involved in early DNA damage response. {ECO:0000269|PubMed:24507776}.FUNCTION: Dual-specificity phosphatase involved in DNA damage response. Essential regulator of the G2 DNA damage checkpoint: following DNA damage, translocates to the nucleus and dephosphorylates FZR1/CDH1, a key activator of the anaphase promoting complex/cyclosome (APC/C). Dephosphorylates SIRT2 around early anaphase. Dephosphorylation of FZR1/CDH1 activates the APC/C, leading to the ubiquitination of PLK1, preventing entry into mitosis. Preferentially dephosphorylates proteins modified by proline-directed kinases. {ECO:0000269|PubMed:17488717, ECO:0000269|PubMed:18662541, ECO:0000269|PubMed:9367992}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCDC14Bchr9:98766983chr9:99304174ENST00000265659413214_374165472.0DomainTyrosine-protein phosphatase
TgeneCDC14Bchr9:98766983chr9:99304174ENST00000375236413214_374165486.0DomainTyrosine-protein phosphatase
TgeneCDC14Bchr9:98766983chr9:99304174ENST00000375240413214_374165460.0DomainTyrosine-protein phosphatase
TgeneCDC14Bchr9:98766983chr9:99304174ENST00000375241414214_374165499.0DomainTyrosine-protein phosphatase
TgeneCDC14Bchr9:98766983chr9:99304174ENST00000375242414214_374128462.0DomainTyrosine-protein phosphatase
TgeneCDC14Bchr9:98766983chr9:99304174ENST00000463569414214_374165518.0DomainTyrosine-protein phosphatase
TgeneCDC14Bchr9:98766983chr9:99304174ENST00000265659413199_212165472.0RegionNote=Linker
TgeneCDC14Bchr9:98766983chr9:99304174ENST00000265659413213_379165472.0RegionNote=B
TgeneCDC14Bchr9:98766983chr9:99304174ENST00000375236413199_212165486.0RegionNote=Linker
TgeneCDC14Bchr9:98766983chr9:99304174ENST00000375236413213_379165486.0RegionNote=B
TgeneCDC14Bchr9:98766983chr9:99304174ENST00000375240413199_212165460.0RegionNote=Linker
TgeneCDC14Bchr9:98766983chr9:99304174ENST00000375240413213_379165460.0RegionNote=B
TgeneCDC14Bchr9:98766983chr9:99304174ENST00000375241414199_212165499.0RegionNote=Linker
TgeneCDC14Bchr9:98766983chr9:99304174ENST00000375241414213_379165499.0RegionNote=B
TgeneCDC14Bchr9:98766983chr9:99304174ENST00000375242414199_212128462.0RegionNote=Linker
TgeneCDC14Bchr9:98766983chr9:99304174ENST00000375242414213_379128462.0RegionNote=B
TgeneCDC14Bchr9:98766983chr9:99304174ENST00000463569414199_212165518.0RegionNote=Linker
TgeneCDC14Bchr9:98766983chr9:99304174ENST00000463569414213_379165518.0RegionNote=B

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneERCC6L2chr9:98766983chr9:99304174ENST00000288985+114146_3320713.0DomainHelicase ATP-binding
HgeneERCC6L2chr9:98766983chr9:99304174ENST00000288985+114523_6730713.0DomainHelicase C-terminal
HgeneERCC6L2chr9:98766983chr9:99304174ENST00000437817+112146_3320524.0DomainHelicase ATP-binding
HgeneERCC6L2chr9:98766983chr9:99304174ENST00000437817+112523_6730524.0DomainHelicase C-terminal
HgeneERCC6L2chr9:98766983chr9:99304174ENST00000288985+114283_2860713.0MotifNote=DEAH box
HgeneERCC6L2chr9:98766983chr9:99304174ENST00000437817+112283_2860524.0MotifNote=DEAH box
HgeneERCC6L2chr9:98766983chr9:99304174ENST00000288985+114159_1660713.0Nucleotide bindingATP
HgeneERCC6L2chr9:98766983chr9:99304174ENST00000437817+112159_1660524.0Nucleotide bindingATP
TgeneCDC14Bchr9:98766983chr9:99304174ENST000002656594131_54165472.0MotifNucleolar localization signal
TgeneCDC14Bchr9:98766983chr9:99304174ENST000003752364131_54165486.0MotifNucleolar localization signal
TgeneCDC14Bchr9:98766983chr9:99304174ENST000003752404131_54165460.0MotifNucleolar localization signal
TgeneCDC14Bchr9:98766983chr9:99304174ENST000003752414141_54165499.0MotifNucleolar localization signal
TgeneCDC14Bchr9:98766983chr9:99304174ENST000003752424141_54128462.0MotifNucleolar localization signal
TgeneCDC14Bchr9:98766983chr9:99304174ENST000004635694141_54165518.0MotifNucleolar localization signal
TgeneCDC14Bchr9:98766983chr9:99304174ENST0000026565941344_198165472.0RegionNote=A
TgeneCDC14Bchr9:98766983chr9:99304174ENST0000037523641344_198165486.0RegionNote=A
TgeneCDC14Bchr9:98766983chr9:99304174ENST0000037524041344_198165460.0RegionNote=A
TgeneCDC14Bchr9:98766983chr9:99304174ENST0000037524141444_198165499.0RegionNote=A
TgeneCDC14Bchr9:98766983chr9:99304174ENST0000037524241444_198128462.0RegionNote=A
TgeneCDC14Bchr9:98766983chr9:99304174ENST0000046356941444_198165518.0RegionNote=A


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Fusion Gene Sequence for ERCC6L2-CDC14B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>27319_27319_1_ERCC6L2-CDC14B_ERCC6L2_chr9_98766983_ENST00000407474_CDC14B_chr9_99304174_ENST00000265659_length(transcript)=2049nt_BP=1130nt
CAGAAATTAGATAACATCCTAAATCCAAAAGAAAAGCATATTTTTTATAAAAGTGAGAAGATTTTAGAACAGAATATTTCTTCCAAGTCT
GACGAGAAAAAAATTAAAAATACAGATAAACATTGCATTTTACAGAATGTCACAGAATCAGAAGATAGTGATGTCATCTGTCCTACACAA
TACACAACTGAGAGATTCCCCGACAATAGTATAAGGTTTAAGCCACCCTTGGAAGGATCTGAGGATTCTGAAACAGAACACACTGTAAAA
ACAAGAAATAATGATAATAGTCGAAACACTGATGACAAAAGAAATGGAATAATTTCAAAAAAGTTAAGTCCTGAGAACACAACCCTGAAA
TCTATTTTGAAAAGAAAAGGCACCAGTGATATCAGTGATGAATCTGATGACATTGAAATTTCTTCCAAGTCAAGAGTAAGAAAGAGAGCT
AGTTCATTGAGGTTTAAGAGAATAAAAGAAACCAAAAAAGAACTTCACAATTCTCCCAAAACAATGAACAAAACAAACCAAGTGTATGCA
GCAAATGAGGATCATAACTCTCAGTTTATTGATGATTATTCATCCTCAGATGAGAGTTTATCCGTCAGCCACTTCAGTTTCTCTAAACAG
AGCCACAGACCAAGAACTATAAGAGACAGAACTAGTTTTTCTTCAAAATTGCCTAGCCATAATAAGAAAAATAGCACTTTTATTCCAAGA
AAACCAATGAAATGTTCAAATGAGAAAGTTGTTAATCAAGAGCAGTCGTATGAATCAATGGATAAATTTTTAGATGGCGTTCAGGAAGTG
GCTTATATTCACTCAAACCAGAATGTAATTGGATCGAGCAAAGCTGAAAATCACATGAGCCGATGGGCAGCACATGACGTATTTGAGTTG
AAGCAGTTTTCTCAGCTGCCTGCTAACATAGCTGTTTGCAGTTCTAAGACATATAAAGAAAAAGTGGATGCAGATACATTGCCACACACA
AAGAAAGGCCAGCAACCGAGTGAAGGCAGCATTTCACTTCCTCTTTACATTTCAAATCCTGTAAACCAGAAGAAGAAAAAAGTCTACCAT
ACAAACCAGACCACCTTCATAATTGGAGAAACACCAAAAGGAATCCGCAGAGATGCTGCCTATGGAAGTTGCAATTTCTACATTACACTT
CTTGACTGTTTTCATGCAGTAAAGAAGGCAATGCAGTATGGCTTCCTTAATTTCAACTCATTTAACCTTGATGAATATGAACACTATGAA
AAAGCAGAAAATGGAGATTTAAATTGGATAATACCAGACCGATTTATTGCCTTCTGTGGACCTCATTCAAGAGCCAGACTTGAAAGTGGT
TACCACCAACATTCTCCTGAGACTTATATTCAATATTTTAAGAATCACAATGTTACTACCATTATTCGTCTGAATAAAAGGATGTATGAT
GCCAAACGCTTTACGGATGCTGGCTTCGATCACCATGATCTTTTCTTTGCGGATGGCAGCACCCCTACTGATGCCATTGTCAAAGAATTC
CTAGATATCTGTGAAAATGCTGAGGGTGCCATTGCAGTACATTGCAAAGCTGGCCTTGGTCGCACGGGCACTCTGATAGCCTGCTACATC
ATGAAGCATTACAGGATGACAGCAGCCGAGACCATTGCGTGGGTCAGGATCTGCAGACCTGGCTCGGTGATTGGGCCTCAGCAGCAGTTT
TTGGTGATGAAGCAAACCAACCTCTGGCTGGAAGGGGACTATTTTCGTCAGAAGTTAAAGGGGCAGGAGAATGGACAACACAGAGCAGCC
TTCTCCAAACTTCTCTCTGGCGTTGATGACATTTCCATAAATGGGGTCGAGAATCAAGATCAGCAAGAACCCGAACCGTACAGTGATGAT
GACGAAATCAATGGAGTGACACAAGGTGATAGACTTCGGGCCTTGAAAAGCAGAAGACAATCCAAAACAAACGCTATTCCTCTCACCGAT

>27319_27319_1_ERCC6L2-CDC14B_ERCC6L2_chr9_98766983_ENST00000407474_CDC14B_chr9_99304174_ENST00000265659_length(amino acids)=606AA_BP=293
MEGSEDSETEHTVKTRNNDNSRNTDDKRNGIISKKLSPENTTLKSILKRKGTSDISDESDDIEISSKSRVRKRASSLRFKRIKETKKELH
NSPKTMNKTNQVYAANEDHNSQFIDDYSSSDESLSVSHFSFSKQSHRPRTIRDRTSFSSKLPSHNKKNSTFIPRKPMKCSNEKVVNQEQS
YESMDKFLDGVQEVAYIHSNQNVIGSSKAENHMSRWAAHDVFELKQFSQLPANIAVCSSKTYKEKVDADTLPHTKKGQQPSEGSISLPLY
ISNPVNQKKKKVYHTNQTTFIIGETPKGIRRDAAYGSCNFYITLLDCFHAVKKAMQYGFLNFNSFNLDEYEHYEKAENGDLNWIIPDRFI
AFCGPHSRARLESGYHQHSPETYIQYFKNHNVTTIIRLNKRMYDAKRFTDAGFDHHDLFFADGSTPTDAIVKEFLDICENAEGAIAVHCK
AGLGRTGTLIACYIMKHYRMTAAETIAWVRICRPGSVIGPQQQFLVMKQTNLWLEGDYFRQKLKGQENGQHRAAFSKLLSGVDDISINGV

--------------------------------------------------------------
>27319_27319_2_ERCC6L2-CDC14B_ERCC6L2_chr9_98766983_ENST00000407474_CDC14B_chr9_99304174_ENST00000375236_length(transcript)=2091nt_BP=1130nt
CAGAAATTAGATAACATCCTAAATCCAAAAGAAAAGCATATTTTTTATAAAAGTGAGAAGATTTTAGAACAGAATATTTCTTCCAAGTCT
GACGAGAAAAAAATTAAAAATACAGATAAACATTGCATTTTACAGAATGTCACAGAATCAGAAGATAGTGATGTCATCTGTCCTACACAA
TACACAACTGAGAGATTCCCCGACAATAGTATAAGGTTTAAGCCACCCTTGGAAGGATCTGAGGATTCTGAAACAGAACACACTGTAAAA
ACAAGAAATAATGATAATAGTCGAAACACTGATGACAAAAGAAATGGAATAATTTCAAAAAAGTTAAGTCCTGAGAACACAACCCTGAAA
TCTATTTTGAAAAGAAAAGGCACCAGTGATATCAGTGATGAATCTGATGACATTGAAATTTCTTCCAAGTCAAGAGTAAGAAAGAGAGCT
AGTTCATTGAGGTTTAAGAGAATAAAAGAAACCAAAAAAGAACTTCACAATTCTCCCAAAACAATGAACAAAACAAACCAAGTGTATGCA
GCAAATGAGGATCATAACTCTCAGTTTATTGATGATTATTCATCCTCAGATGAGAGTTTATCCGTCAGCCACTTCAGTTTCTCTAAACAG
AGCCACAGACCAAGAACTATAAGAGACAGAACTAGTTTTTCTTCAAAATTGCCTAGCCATAATAAGAAAAATAGCACTTTTATTCCAAGA
AAACCAATGAAATGTTCAAATGAGAAAGTTGTTAATCAAGAGCAGTCGTATGAATCAATGGATAAATTTTTAGATGGCGTTCAGGAAGTG
GCTTATATTCACTCAAACCAGAATGTAATTGGATCGAGCAAAGCTGAAAATCACATGAGCCGATGGGCAGCACATGACGTATTTGAGTTG
AAGCAGTTTTCTCAGCTGCCTGCTAACATAGCTGTTTGCAGTTCTAAGACATATAAAGAAAAAGTGGATGCAGATACATTGCCACACACA
AAGAAAGGCCAGCAACCGAGTGAAGGCAGCATTTCACTTCCTCTTTACATTTCAAATCCTGTAAACCAGAAGAAGAAAAAAGTCTACCAT
ACAAACCAGACCACCTTCATAATTGGAGAAACACCAAAAGGAATCCGCAGAGATGCTGCCTATGGAAGTTGCAATTTCTACATTACACTT
CTTGACTGTTTTCATGCAGTAAAGAAGGCAATGCAGTATGGCTTCCTTAATTTCAACTCATTTAACCTTGATGAATATGAACACTATGAA
AAAGCAGAAAATGGAGATTTAAATTGGATAATACCAGACCGATTTATTGCCTTCTGTGGACCTCATTCAAGAGCCAGACTTGAAAGTGGT
TACCACCAACATTCTCCTGAGACTTATATTCAATATTTTAAGAATCACAATGTTACTACCATTATTCGTCTGAATAAAAGGATGTATGAT
GCCAAACGCTTTACGGATGCTGGCTTCGATCACCATGATCTTTTCTTTGCGGATGGCAGCACCCCTACTGATGCCATTGTCAAAGAATTC
CTAGATATCTGTGAAAATGCTGAGGGTGCCATTGCAGTACATTGCAAAGCTGGCCTTGGTCGCACGGGCACTCTGATAGCCTGCTACATC
ATGAAGCATTACAGGATGACAGCAGCCGAGACCATTGCGTGGGTCAGGATCTGCAGACCTGGCTCGGTGATTGGGCCTCAGCAGCAGTTT
TTGGTGATGAAGCAAACCAACCTCTGGCTGGAAGGGGACTATTTTCGTCAGAAGTTAAAGGGGCAGGAGAATGGACAACACAGAGCAGCC
TTCTCCAAACTTCTCTCTGGCGTTGATGACATTTCCATAAATGGGGTCGAGAATCAAGATCAGCAAGAACCCGAACCGTACAGTGATGAT
GACGAAATCAATGGAGTGACACAAGGTGATAGACTTCGGGCCTTGAAAAGCAGAAGACAATCCAAAACAAACGCTATTCCTCTCACATGT
CCCCTAGCTGTGCTGACCTCTGCACTGTGTAGTGTTGTCATCTGGTGGATTGTTTGTGACTACATTCTTCCCATCCTGCTATTCTGTCTC

>27319_27319_2_ERCC6L2-CDC14B_ERCC6L2_chr9_98766983_ENST00000407474_CDC14B_chr9_99304174_ENST00000375236_length(amino acids)=620AA_BP=293
MEGSEDSETEHTVKTRNNDNSRNTDDKRNGIISKKLSPENTTLKSILKRKGTSDISDESDDIEISSKSRVRKRASSLRFKRIKETKKELH
NSPKTMNKTNQVYAANEDHNSQFIDDYSSSDESLSVSHFSFSKQSHRPRTIRDRTSFSSKLPSHNKKNSTFIPRKPMKCSNEKVVNQEQS
YESMDKFLDGVQEVAYIHSNQNVIGSSKAENHMSRWAAHDVFELKQFSQLPANIAVCSSKTYKEKVDADTLPHTKKGQQPSEGSISLPLY
ISNPVNQKKKKVYHTNQTTFIIGETPKGIRRDAAYGSCNFYITLLDCFHAVKKAMQYGFLNFNSFNLDEYEHYEKAENGDLNWIIPDRFI
AFCGPHSRARLESGYHQHSPETYIQYFKNHNVTTIIRLNKRMYDAKRFTDAGFDHHDLFFADGSTPTDAIVKEFLDICENAEGAIAVHCK
AGLGRTGTLIACYIMKHYRMTAAETIAWVRICRPGSVIGPQQQFLVMKQTNLWLEGDYFRQKLKGQENGQHRAAFSKLLSGVDDISINGV

--------------------------------------------------------------
>27319_27319_3_ERCC6L2-CDC14B_ERCC6L2_chr9_98766983_ENST00000407474_CDC14B_chr9_99304174_ENST00000375240_length(transcript)=3180nt_BP=1130nt
CAGAAATTAGATAACATCCTAAATCCAAAAGAAAAGCATATTTTTTATAAAAGTGAGAAGATTTTAGAACAGAATATTTCTTCCAAGTCT
GACGAGAAAAAAATTAAAAATACAGATAAACATTGCATTTTACAGAATGTCACAGAATCAGAAGATAGTGATGTCATCTGTCCTACACAA
TACACAACTGAGAGATTCCCCGACAATAGTATAAGGTTTAAGCCACCCTTGGAAGGATCTGAGGATTCTGAAACAGAACACACTGTAAAA
ACAAGAAATAATGATAATAGTCGAAACACTGATGACAAAAGAAATGGAATAATTTCAAAAAAGTTAAGTCCTGAGAACACAACCCTGAAA
TCTATTTTGAAAAGAAAAGGCACCAGTGATATCAGTGATGAATCTGATGACATTGAAATTTCTTCCAAGTCAAGAGTAAGAAAGAGAGCT
AGTTCATTGAGGTTTAAGAGAATAAAAGAAACCAAAAAAGAACTTCACAATTCTCCCAAAACAATGAACAAAACAAACCAAGTGTATGCA
GCAAATGAGGATCATAACTCTCAGTTTATTGATGATTATTCATCCTCAGATGAGAGTTTATCCGTCAGCCACTTCAGTTTCTCTAAACAG
AGCCACAGACCAAGAACTATAAGAGACAGAACTAGTTTTTCTTCAAAATTGCCTAGCCATAATAAGAAAAATAGCACTTTTATTCCAAGA
AAACCAATGAAATGTTCAAATGAGAAAGTTGTTAATCAAGAGCAGTCGTATGAATCAATGGATAAATTTTTAGATGGCGTTCAGGAAGTG
GCTTATATTCACTCAAACCAGAATGTAATTGGATCGAGCAAAGCTGAAAATCACATGAGCCGATGGGCAGCACATGACGTATTTGAGTTG
AAGCAGTTTTCTCAGCTGCCTGCTAACATAGCTGTTTGCAGTTCTAAGACATATAAAGAAAAAGTGGATGCAGATACATTGCCACACACA
AAGAAAGGCCAGCAACCGAGTGAAGGCAGCATTTCACTTCCTCTTTACATTTCAAATCCTGTAAACCAGAAGAAGAAAAAAGTCTACCAT
ACAAACCAGACCACCTTCATAATTGGAGAAACACCAAAAGGAATCCGCAGAGATGCTGCCTATGGAAGTTGCAATTTCTACATTACACTT
CTTGACTGTTTTCATGCAGTAAAGAAGGCAATGCAGTATGGCTTCCTTAATTTCAACTCATTTAACCTTGATGAATATGAACACTATGAA
AAAGCAGAAAATGGAGATTTAAATTGGATAATACCAGACCGATTTATTGCCTTCTGTGGACCTCATTCAAGAGCCAGACTTGAAAGTGGT
TACCACCAACATTCTCCTGAGACTTATATTCAATATTTTAAGAATCACAATGTTACTACCATTATTCGTCTGAATAAAAGGATGTATGAT
GCCAAACGCTTTACGGATGCTGGCTTCGATCACCATGATCTTTTCTTTGCGGATGGCAGCACCCCTACTGATGCCATTGTCAAAGAATTC
CTAGATATCTGTGAAAATGCTGAGGGTGCCATTGCAGTACATTGCAAAGCTGGCCTTGGTCGCACGGGCACTCTGATAGCCTGCTACATC
ATGAAGCATTACAGGATGACAGCAGCCGAGACCATTGCGTGGGTCAGGATCTGCAGACCTGGCTCGGTGATTGGGCCTCAGCAGCAGTTT
TTGGTGATGAAGCAAACCAACCTCTGGCTGGAAGGGGACTATTTTCGTCAGAAGTTAAAGGGGCAGGAGAATGGACAACACAGAGCAGCC
TTCTCCAAACTTCTCTCTGGCGTTGATGACATTTCCATAAATGGGGTCGAGAATCAAGATCAGCAAGAACCCGAACCGTACAGTGATGAT
GACGAAATCAATGGAGTGACACAAGGTGATAGACTTCGGGCCTTGAAAAGCAGAAGACAATCCAAAACAAACGCTATTCCTCTCACTCTC
TCCATTTCAAGGACTAAAACAGTCTTGCGTTAAGTAAAAACCTGTGACCAGAGCTGAAGGAAGACTCTAGGACTGAAAACTGCAACAGAA
ATTAGCACAATTTGAAAACAAAACAAAATTGCAAAAGCCTTAGTTGCTTTTTCCACCTAAGAAGTTGATCAATGGAGAAAATGTCCACTG
GAGTTTGAATAATGAACTTTGAGTTTGGGTGCAAGCAAATGACTCAGAGAAGGGTCCAGCTCTCAAGCTGAATGACAAACATGCTGTTGT
AAATTTAGTCTCAGGTGTAAATACCCAAGCCCTCTGGTACCCAGGGAGCTGGCTGGTCTGTGGTGCATGTGTGTCCCTGTGATGGCAATC
ATTGTAGTTGCTGGCCTTCAGAAGAATTGAGGATCTGATGGAGGTTTTTTATGTATTTATTTTCTGTTCACCTTGTGACCCTGTGTCAAA
ATTTATAAAGATACAAAAGGCATTACTGAAATGGTACTTTCTGTAATTTGATACTATTTGGCTTAATCATCTTCACTTGACTATTTGTAA
TACTGTTGTAATGTTAACTCTGTTAAGTACCCAAGCTGCTTGTCTTCCACCAAAGAGTGCTTTATTAACAAGAATCTGTGAAAATCACAT
TTAAACACTGTTGCATGTTGTAAGACCAGGTGGTACCTTAGTAACCTAAAACTTGCAAGAGAATATTAATGGTAGCTTTAGAAGACTCAG
GAGGAGAAACTGACTTCAGAGTTGGAAGATGTTGCAAGTCGTTCCTTTTTCTGTCCTTCAGGGACTGAAGAACTGGGAGGCTGCCCATTG
TTTGGTTGCCAGTCATACAAATTAAAATCATATTTCCTTCCATGAATGGAAGAAACACACTATTGGTTTTTCCCCTTGGAAACAGCAATC
CCAAATAATGTCGGCTTACAAAAAAAAAAAGTTACCACTTTTTTAGAGTCCTTCCCTGTAACATTGGATTTTTTTTTTCCCTTATGAGAT
CCACCTAAGGCCATTGACGTGGCCTGCGATCTCAGTGACAATGATCTGCTTCTGGATCTCACTGTTGCCTTTGGTTAGGGAACACAACTA
GTAACTCTGCAGAGTGCCTTCTCCCGCAGCCCTACTGGAACACAGCAGAGTCTGTGCCATGAAGCAGTTACAGAAACAGAATTGATGTGC

>27319_27319_3_ERCC6L2-CDC14B_ERCC6L2_chr9_98766983_ENST00000407474_CDC14B_chr9_99304174_ENST00000375240_length(amino acids)=594AA_BP=293
MEGSEDSETEHTVKTRNNDNSRNTDDKRNGIISKKLSPENTTLKSILKRKGTSDISDESDDIEISSKSRVRKRASSLRFKRIKETKKELH
NSPKTMNKTNQVYAANEDHNSQFIDDYSSSDESLSVSHFSFSKQSHRPRTIRDRTSFSSKLPSHNKKNSTFIPRKPMKCSNEKVVNQEQS
YESMDKFLDGVQEVAYIHSNQNVIGSSKAENHMSRWAAHDVFELKQFSQLPANIAVCSSKTYKEKVDADTLPHTKKGQQPSEGSISLPLY
ISNPVNQKKKKVYHTNQTTFIIGETPKGIRRDAAYGSCNFYITLLDCFHAVKKAMQYGFLNFNSFNLDEYEHYEKAENGDLNWIIPDRFI
AFCGPHSRARLESGYHQHSPETYIQYFKNHNVTTIIRLNKRMYDAKRFTDAGFDHHDLFFADGSTPTDAIVKEFLDICENAEGAIAVHCK
AGLGRTGTLIACYIMKHYRMTAAETIAWVRICRPGSVIGPQQQFLVMKQTNLWLEGDYFRQKLKGQENGQHRAAFSKLLSGVDDISINGV

--------------------------------------------------------------
>27319_27319_4_ERCC6L2-CDC14B_ERCC6L2_chr9_98766983_ENST00000407474_CDC14B_chr9_99304174_ENST00000375241_length(transcript)=5770nt_BP=1130nt
CAGAAATTAGATAACATCCTAAATCCAAAAGAAAAGCATATTTTTTATAAAAGTGAGAAGATTTTAGAACAGAATATTTCTTCCAAGTCT
GACGAGAAAAAAATTAAAAATACAGATAAACATTGCATTTTACAGAATGTCACAGAATCAGAAGATAGTGATGTCATCTGTCCTACACAA
TACACAACTGAGAGATTCCCCGACAATAGTATAAGGTTTAAGCCACCCTTGGAAGGATCTGAGGATTCTGAAACAGAACACACTGTAAAA
ACAAGAAATAATGATAATAGTCGAAACACTGATGACAAAAGAAATGGAATAATTTCAAAAAAGTTAAGTCCTGAGAACACAACCCTGAAA
TCTATTTTGAAAAGAAAAGGCACCAGTGATATCAGTGATGAATCTGATGACATTGAAATTTCTTCCAAGTCAAGAGTAAGAAAGAGAGCT
AGTTCATTGAGGTTTAAGAGAATAAAAGAAACCAAAAAAGAACTTCACAATTCTCCCAAAACAATGAACAAAACAAACCAAGTGTATGCA
GCAAATGAGGATCATAACTCTCAGTTTATTGATGATTATTCATCCTCAGATGAGAGTTTATCCGTCAGCCACTTCAGTTTCTCTAAACAG
AGCCACAGACCAAGAACTATAAGAGACAGAACTAGTTTTTCTTCAAAATTGCCTAGCCATAATAAGAAAAATAGCACTTTTATTCCAAGA
AAACCAATGAAATGTTCAAATGAGAAAGTTGTTAATCAAGAGCAGTCGTATGAATCAATGGATAAATTTTTAGATGGCGTTCAGGAAGTG
GCTTATATTCACTCAAACCAGAATGTAATTGGATCGAGCAAAGCTGAAAATCACATGAGCCGATGGGCAGCACATGACGTATTTGAGTTG
AAGCAGTTTTCTCAGCTGCCTGCTAACATAGCTGTTTGCAGTTCTAAGACATATAAAGAAAAAGTGGATGCAGATACATTGCCACACACA
AAGAAAGGCCAGCAACCGAGTGAAGGCAGCATTTCACTTCCTCTTTACATTTCAAATCCTGTAAACCAGAAGAAGAAAAAAGTCTACCAT
ACAAACCAGACCACCTTCATAATTGGAGAAACACCAAAAGGAATCCGCAGAGATGCTGCCTATGGAAGTTGCAATTTCTACATTACACTT
CTTGACTGTTTTCATGCAGTAAAGAAGGCAATGCAGTATGGCTTCCTTAATTTCAACTCATTTAACCTTGATGAATATGAACACTATGAA
AAAGCAGAAAATGGAGATTTAAATTGGATAATACCAGACCGATTTATTGCCTTCTGTGGACCTCATTCAAGAGCCAGACTTGAAAGTGGT
TACCACCAACATTCTCCTGAGACTTATATTCAATATTTTAAGAATCACAATGTTACTACCATTATTCGTCTGAATAAAAGGATGTATGAT
GCCAAACGCTTTACGGATGCTGGCTTCGATCACCATGATCTTTTCTTTGCGGATGGCAGCACCCCTACTGATGCCATTGTCAAAGAATTC
CTAGATATCTGTGAAAATGCTGAGGGTGCCATTGCAGTACATTGCAAAGCTGGCCTTGGTCGCACGGGCACTCTGATAGCCTGCTACATC
ATGAAGCATTACAGGATGACAGCAGCCGAGACCATTGCGTGGGTCAGGATCTGCAGACCTGGCTCGGTGATTGGGCCTCAGCAGCAGTTT
TTGGTGATGAAGCAAACCAACCTCTGGCTGGAAGGGGACTATTTTCGTCAGAAGTTAAAGGGGCAGGAGAATGGACAACACAGAGCAGCC
TTCTCCAAACTTCTCTCTGGCGTTGATGACATTTCCATAAATGGGGTCGAGAATCAAGATCAGCAAGAACCCGAACCGTACAGTGATGAT
GACGAAATCAATGGAGTGACACAAGGTGATAGACTTCGGGCCTTGAAAAGCAGAAGACAATCCAAAACAAACGCTATTCCTCTCACAGTA
ATTCTTCAATCCAGTGTTCAGAGCTGTAAAACATCTGAACCTAACATTTCTGGCAGTGCAGGCATTACTAAAAGAACCACCAGATCTGCT
TCAAGGAAAAGCAGTGTTAAAAGTCTCTCCATTTCAAGGACTAAAACAGTCTTGCGTTAAGTAAAAACCTGTGACCAGAGCTGAAGGAAG
ACTCTAGGACTGAAAACTGCAACAGAAATTAGCACAATTTGAAAACAAAACAAAATTGCAAAAGCCTTAGTTGCTTTTTCCACCTAAGAA
GTTGATCAATGGAGAAAATGTCCACTGGAGTTTGAATAATGAACTTTGAGTTTGGGTGCAAGCAAATGACTCAGAGAAGGGTCCAGCTCT
CAAGCTGAATGACAAACATGCTGTTGTAAATTTAGTCTCAGGTGTAAATACCCAAGCCCTCTGGTACCCAGGGAGCTGGCTGGTCTGTGG
TGCATGTGTGTCCCTGTGATGGCAATCATTGTAGTTGCTGGCCTTCAGAAGAATTGAGGATCTGATGGAGGTTTTTTATGTATTTATTTT
CTGTTCACCTTGTGACCCTGTGTCAAAATTTATAAAGATACAAAAGGCATTACTGAAATGGTACTTTCTGTAATTTGATACTATTTGGCT
TAATCATCTTCACTTGACTATTTGTAATACTGTTGTAATGTTAACTCTGTTAAGTACCCAAGCTGCTTGTCTTCCACCAAAGAGTGCTTT
ATTAACAAGAATCTGTGAAAATCACATTTAAACACTGTTGCATGTTGTAAGACCAGGTGGTACCTTAGTAACCTAAAACTTGCAAGAGAA
TATTAATGGTAGCTTTAGAAGACTCAGGAGGAGAAACTGACTTCAGAGTTGGAAGATGTTGCAAGTCGTTCCTTTTTCTGTCCTTCAGGG
ACTGAAGAACTGGGAGGCTGCCCATTGTTTGGTTGCCAGTCATACAAATTAAAATCATATTTCCTTCCATGAATGGAAGAAACACACTAT
TGGTTTTTCCCCTTGGAAACAGCAATCCCAAATAATGTCGGCTTACAAAAAAAAAAAGTTACCACTTTTTTAGAGTCCTTCCCTGTAACA
TTGGATTTTTTTTTTCCCTTATGAGATCCACCTAAGGCCATTGACGTGGCCTGCGATCTCAGTGACAATGATCTGCTTCTGGATCTCACT
GTTGCCTTTGGTTAGGGAACACAACTAGTAACTCTGCAGAGTGCCTTCTCCCGCAGCCCTACTGGAACACAGCAGAGTCTGTGCCATGAA
GCAGTTACAGAAACAGAATTGATGTGCTGCTAAAAAAAAAAAAAAAAATGGGGCCCGAAATAAAAGAATATATAGTACTCACCTCAGTTC
CTTCCATAAGAAGTGGGTGGTTTAATGATTGTTAAGCCATTTTTGCCTGTGCCGGGAGCATGGAGGGCTGAGATGTCGACAGGCAGTGGG
AAACAAATGCCCTCCTAAGCCACAAGGCGTGCGCCAGATTAGTAGGCAACTCCATTTTAAGAAGCTGCCTTTTTCACAAAACTGGAAGAA
ATAAAAGCGGTTGGAATAAACAAGTTAAAAGTCTTTAATGCAAAAAGTAATTGAAAGGCAGTGCCTCCATTTTGGTGTACTTTCTTGGAA
GAAAGTATAAAATTGACCGGCATCATGAGAGACGGAAGATGCCGTGTTCTCAGCCAAACAAGCAACTCTTTCCCCGCCAGGCACTGTCGG
GTGGGGTCAGGCCAGCTTTTAAACACTGGGGACTGGATCACAGAAAAACAGTGGTTTTCTGTCCCTGGAAATGAATAGGCACAAAGACCC
ACTTGGCTGTGGGCAGACTACTCTTCAATAAGATTTGGGTGGGAGGAGGAACATTCCTTTTGCTATTTTGAGCTGAGACAATATAAATAT
TCAAACTGTGCCATGCATAAAGCATTGAATTCTCAGGGCACCTCTTCTTCCCCTTACCCCTTTTAAGGCCATCCCCTCCATTAATAATAA
TCCAGGTAGTTGTGAAAATCGTGCTTCTATCTGATCCCTTCTTAGTTTGGCTTTTCATCCCATCAGAACAAGTAAACGTAGGCGCCACAG
CTCTTGTGAGTACTGTCTCCCTCACGGTGAATGAGCCTCCTGGTGTTTCGTCCAAGAAAAGAAAGGGTGTCACTGGAACCACAGCCCTTT
TTCATTTTATAAACTGCCTCTTCATGTTGCCTGCTCAAGTTTCCACCTAGAATTGCTATCACTGTGGCTCTTTCTAAAAATCTTTCTATT
TAACTGGTTCACTGAAATTAGTCATAGAAAACTTGTGATTTGGTGAAGAGGCATTCCTTGTAATAACCAAATGACTTGGGATGGTGTGCA
TAGCAAGGGCAGTGTTACACTTATGAGGACTGTCTCTAGCATCCAGGAAGTCTCTGGGTCTGAGGGATGGAAAGTTCTTCCTGCTATGAA
TGAGAGTGGACTCTTCCCCTCACCCCCAACTGAAACCACAAACAACCAGAATCTTCTGGAATTCTGACTTAGAGTCGTTGTTATAGAAGA
CCTTGTTGCTATGGAACATGAAACTGTGTGTCAGATGGAGAGATCCCCTTAACCTAAGAGCCTTAAATAGCCCTGAAAGTACACTGGGAC
GGTTTGCGATGGAATTAAAATTGGAAGTGAATATTTTTAGGTGCTCTTGAAGCTTTCTGGGGACTCAAAATTATCAAAAGTCAGGGACAG
TCCGGAGGAAGAGCGTCTGCAAAACTGGGTTCCTAGAAGTATAGACGGACTTAGCTTTTTGTAGAATTTGGTGAGGAGCAGCGCCTCGTG
AGAGCAGAATGGCCTGGCGTGGCCAGTGCTTCCCGGCAGCACGCAGCTCTGCGGCCTCCAGAATTCCCCTGTTCTGAGCTTGATGCCCCT
AGCCTGTCCCCTACCTACTTCCTCCCCTCCTCTCTAGCCCTCTCACAGGGGTGATTGCTACCTCTCTGTTTTCTTGGGCCTAGGCAAGTT
TTAGAGGAGTTCCCAAGCATTGTTATGAGGCCAGTGTGCTCGCTGGGCTGGGCGGGATGGCCTGGGCTTGTGTGTGGCCTGAGGGCTCTC
CTGGGGCCTTCTCTTTTCCCAGTCACCTTTGGAGCCACAGAAGCAGTGCACTCATTGGATGTCTGTTCTTAACACAGCTTCTCTTTCTAC
ATTAAAAAAAATCATTATTGCATTTTGGAAAGCAGTGCTCATCAAAAGCAACTTTTAAAACCTATTTTATTGTTCCTTTAAATGTTCTCT
CCCGCTGAAACTGCCCTGGAGAGGCTATCTGCTGCTCTTCCATTTACCCACATCAGGTTATTCTCCATGTCACTCAGTGGAGATGACTCC
AGATGTGTTTAAAGACTGGACAATTCACCTATACTGTGTAGGAAATTACCTCCTTAATTACCTGGTAGAATTGTCAGCAGACATGTTCAT
CCGATGATAGTACTGCAGTTTTCTATTAATAATTTGCAGACTTTTATCTAACCTGCACTCATGTACAGATTATTAAAAGTTTTAAAATGT
AACTGATCAGTATTGATCAATCATTGTCTTGATTTTTTTTTACAGCGTATATTTCTAATCATATTTTTTAAAGCCAAGAGAACTGGTTGA
ATGAATGTTTATTTTCCTGAAGGTATTTTTAAGATAAAGCTTCCTAATGGCGTGTAAACTTTGCATATGTATGTAGTTTGATACATATTG
TCACATTTGAAAATCTTGTGGGTTGTAACTGGTTTTATACAAAATATCGAATAGTGGAAATTGTATAATTACAATCATGTAATTAAAAGT

>27319_27319_4_ERCC6L2-CDC14B_ERCC6L2_chr9_98766983_ENST00000407474_CDC14B_chr9_99304174_ENST00000375241_length(amino acids)=633AA_BP=293
MEGSEDSETEHTVKTRNNDNSRNTDDKRNGIISKKLSPENTTLKSILKRKGTSDISDESDDIEISSKSRVRKRASSLRFKRIKETKKELH
NSPKTMNKTNQVYAANEDHNSQFIDDYSSSDESLSVSHFSFSKQSHRPRTIRDRTSFSSKLPSHNKKNSTFIPRKPMKCSNEKVVNQEQS
YESMDKFLDGVQEVAYIHSNQNVIGSSKAENHMSRWAAHDVFELKQFSQLPANIAVCSSKTYKEKVDADTLPHTKKGQQPSEGSISLPLY
ISNPVNQKKKKVYHTNQTTFIIGETPKGIRRDAAYGSCNFYITLLDCFHAVKKAMQYGFLNFNSFNLDEYEHYEKAENGDLNWIIPDRFI
AFCGPHSRARLESGYHQHSPETYIQYFKNHNVTTIIRLNKRMYDAKRFTDAGFDHHDLFFADGSTPTDAIVKEFLDICENAEGAIAVHCK
AGLGRTGTLIACYIMKHYRMTAAETIAWVRICRPGSVIGPQQQFLVMKQTNLWLEGDYFRQKLKGQENGQHRAAFSKLLSGVDDISINGV
ENQDQQEPEPYSDDDEINGVTQGDRLRALKSRRQSKTNAIPLTVILQSSVQSCKTSEPNISGSAGITKRTTRSASRKSSVKSLSISRTKT

--------------------------------------------------------------
>27319_27319_5_ERCC6L2-CDC14B_ERCC6L2_chr9_98766983_ENST00000407474_CDC14B_chr9_99304174_ENST00000375242_length(transcript)=3271nt_BP=1130nt
CAGAAATTAGATAACATCCTAAATCCAAAAGAAAAGCATATTTTTTATAAAAGTGAGAAGATTTTAGAACAGAATATTTCTTCCAAGTCT
GACGAGAAAAAAATTAAAAATACAGATAAACATTGCATTTTACAGAATGTCACAGAATCAGAAGATAGTGATGTCATCTGTCCTACACAA
TACACAACTGAGAGATTCCCCGACAATAGTATAAGGTTTAAGCCACCCTTGGAAGGATCTGAGGATTCTGAAACAGAACACACTGTAAAA
ACAAGAAATAATGATAATAGTCGAAACACTGATGACAAAAGAAATGGAATAATTTCAAAAAAGTTAAGTCCTGAGAACACAACCCTGAAA
TCTATTTTGAAAAGAAAAGGCACCAGTGATATCAGTGATGAATCTGATGACATTGAAATTTCTTCCAAGTCAAGAGTAAGAAAGAGAGCT
AGTTCATTGAGGTTTAAGAGAATAAAAGAAACCAAAAAAGAACTTCACAATTCTCCCAAAACAATGAACAAAACAAACCAAGTGTATGCA
GCAAATGAGGATCATAACTCTCAGTTTATTGATGATTATTCATCCTCAGATGAGAGTTTATCCGTCAGCCACTTCAGTTTCTCTAAACAG
AGCCACAGACCAAGAACTATAAGAGACAGAACTAGTTTTTCTTCAAAATTGCCTAGCCATAATAAGAAAAATAGCACTTTTATTCCAAGA
AAACCAATGAAATGTTCAAATGAGAAAGTTGTTAATCAAGAGCAGTCGTATGAATCAATGGATAAATTTTTAGATGGCGTTCAGGAAGTG
GCTTATATTCACTCAAACCAGAATGTAATTGGATCGAGCAAAGCTGAAAATCACATGAGCCGATGGGCAGCACATGACGTATTTGAGTTG
AAGCAGTTTTCTCAGCTGCCTGCTAACATAGCTGTTTGCAGTTCTAAGACATATAAAGAAAAAGTGGATGCAGATACATTGCCACACACA
AAGAAAGGCCAGCAACCGAGTGAAGGCAGCATTTCACTTCCTCTTTACATTTCAAATCCTGTAAACCAGAAGAAGAAAAAAGTCTACCAT
ACAAACCAGACCACCTTCATAATTGGAGAAACACCAAAAGGAATCCGCAGAGATGCTGCCTATGGAAGTTGCAATTTCTACATTACACTT
CTTGACTGTTTTCATGCAGTAAAGAAGGCAATGCAGTATGGCTTCCTTAATTTCAACTCATTTAACCTTGATGAATATGAACACTATGAA
AAAGCAGAAAATGGAGATTTAAATTGGATAATACCAGACCGATTTATTGCCTTCTGTGGACCTCATTCAAGAGCCAGACTTGAAAGTGGT
TACCACCAACATTCTCCTGAGACTTATATTCAATATTTTAAGAATCACAATGTTACTACCATTATTCGTCTGAATAAAAGGATGTATGAT
GCCAAACGCTTTACGGATGCTGGCTTCGATCACCATGATCTTTTCTTTGCGGATGGCAGCACCCCTACTGATGCCATTGTCAAAGAATTC
CTAGATATCTGTGAAAATGCTGAGGGTGCCATTGCAGTACATTGCAAAGCTGGCCTTGGTCGCACGGGCACTCTGATAGCCTGCTACATC
ATGAAGCATTACAGGATGACAGCAGCCGAGACCATTGCGTGGGTCAGGATCTGCAGACCTGGCTCGGTGATTGGGCCTCAGCAGCAGTTT
TTGGTGATGAAGCAAACCAACCTCTGGCTGGAAGGGGACTATTTTCGTCAGAAGTTAAAGGGGCAGGAGAATGGACAACACAGAGCAGCC
TTCTCCAAACTTCTCTCTGGCGTTGATGACATTTCCATAAATGGGGTCGAGAATCAAGATCAGCAAGAACCCGAACCGTACAGTGATGAT
GACGAAATCAATGGAGTGACACAAGGTGATAGACTTCGGGCCTTGAAAAGCAGAAGACAATCCAAAACAAACGCTATTCCTCTCACAGTA
ATTCTTCAATCCAGTGTTCAGAGCTGTAAAACATCTGAACCTAACATTTCTGGCAGTGCAGGCATTACTAAAAGAACCACCAGATCTGCT
TCAAGGAAAAGCAGTGTTAAAAGTCTCTCCATTTCAAGGACTAAAACAGTCTTGCGTTAAGTAAAAACCTGTGACCAGAGCTGAAGGAAG
ACTCTAGGACTGAAAACTGCAACAGAAATTAGCACAATTTGAAAACAAAACAAAATTGCAAAAGCCTTAGTTGCTTTTTCCACCTAAGAA
GTTGATCAATGGAGAAAATGTCCACTGGAGTTTGAATAATGAACTTTGAGTTTGGGTGCAAGCAAATGACTCAGAGAAGGGTCCAGCTCT
CAAGCTGAATGACAAACATGCTGTTGTAAATTTAGTCTCAGGTGTAAATACCCAAGCCCTCTGGTACCCAGGGAGCTGGCTGGTCTGTGG
TGCATGTGTGTCCCTGTGATGGCAATCATTGTAGTTGCTGGCCTTCAGAAGAATTGAGGATCTGATGGAGGTTTTTTATGTATTTATTTT
CTGTTCACCTTGTGACCCTGTGTCAAAATTTATAAAGATACAAAAGGCATTACTGAAATGGTACTTTCTGTAATTTGATACTATTTGGCT
TAATCATCTTCACTTGACTATTTGTAATACTGTTGTAATGTTAACTCTGTTAAGTACCCAAGCTGCTTGTCTTCCACCAAAGAGTGCTTT
ATTAACAAGAATCTGTGAAAATCACATTTAAACACTGTTGCATGTTGTAAGACCAGGTGGTACCTTAGTAACCTAAAACTTGCAAGAGAA
TATTAATGGTAGCTTTAGAAGACTCAGGAGGAGAAACTGACTTCAGAGTTGGAAGATGTTGCAAGTCGTTCCTTTTTCTGTCCTTCAGGG
ACTGAAGAACTGGGAGGCTGCCCATTGTTTGGTTGCCAGTCATACAAATTAAAATCATATTTCCTTCCATGAATGGAAGAAACACACTAT
TGGTTTTTCCCCTTGGAAACAGCAATCCCAAATAATGTCGGCTTACAAAAAAAAAAAGTTACCACTTTTTTAGAGTCCTTCCCTGTAACA
TTGGATTTTTTTTTTCCCTTATGAGATCCACCTAAGGCCATTGACGTGGCCTGCGATCTCAGTGACAATGATCTGCTTCTGGATCTCACT
GTTGCCTTTGGTTAGGGAACACAACTAGTAACTCTGCAGAGTGCCTTCTCCCGCAGCCCTACTGGAACACAGCAGAGTCTGTGCCATGAA

>27319_27319_5_ERCC6L2-CDC14B_ERCC6L2_chr9_98766983_ENST00000407474_CDC14B_chr9_99304174_ENST00000375242_length(amino acids)=633AA_BP=293
MEGSEDSETEHTVKTRNNDNSRNTDDKRNGIISKKLSPENTTLKSILKRKGTSDISDESDDIEISSKSRVRKRASSLRFKRIKETKKELH
NSPKTMNKTNQVYAANEDHNSQFIDDYSSSDESLSVSHFSFSKQSHRPRTIRDRTSFSSKLPSHNKKNSTFIPRKPMKCSNEKVVNQEQS
YESMDKFLDGVQEVAYIHSNQNVIGSSKAENHMSRWAAHDVFELKQFSQLPANIAVCSSKTYKEKVDADTLPHTKKGQQPSEGSISLPLY
ISNPVNQKKKKVYHTNQTTFIIGETPKGIRRDAAYGSCNFYITLLDCFHAVKKAMQYGFLNFNSFNLDEYEHYEKAENGDLNWIIPDRFI
AFCGPHSRARLESGYHQHSPETYIQYFKNHNVTTIIRLNKRMYDAKRFTDAGFDHHDLFFADGSTPTDAIVKEFLDICENAEGAIAVHCK
AGLGRTGTLIACYIMKHYRMTAAETIAWVRICRPGSVIGPQQQFLVMKQTNLWLEGDYFRQKLKGQENGQHRAAFSKLLSGVDDISINGV
ENQDQQEPEPYSDDDEINGVTQGDRLRALKSRRQSKTNAIPLTVILQSSVQSCKTSEPNISGSAGITKRTTRSASRKSSVKSLSISRTKT

--------------------------------------------------------------
>27319_27319_6_ERCC6L2-CDC14B_ERCC6L2_chr9_98766983_ENST00000407474_CDC14B_chr9_99304174_ENST00000463569_length(transcript)=2345nt_BP=1130nt
CAGAAATTAGATAACATCCTAAATCCAAAAGAAAAGCATATTTTTTATAAAAGTGAGAAGATTTTAGAACAGAATATTTCTTCCAAGTCT
GACGAGAAAAAAATTAAAAATACAGATAAACATTGCATTTTACAGAATGTCACAGAATCAGAAGATAGTGATGTCATCTGTCCTACACAA
TACACAACTGAGAGATTCCCCGACAATAGTATAAGGTTTAAGCCACCCTTGGAAGGATCTGAGGATTCTGAAACAGAACACACTGTAAAA
ACAAGAAATAATGATAATAGTCGAAACACTGATGACAAAAGAAATGGAATAATTTCAAAAAAGTTAAGTCCTGAGAACACAACCCTGAAA
TCTATTTTGAAAAGAAAAGGCACCAGTGATATCAGTGATGAATCTGATGACATTGAAATTTCTTCCAAGTCAAGAGTAAGAAAGAGAGCT
AGTTCATTGAGGTTTAAGAGAATAAAAGAAACCAAAAAAGAACTTCACAATTCTCCCAAAACAATGAACAAAACAAACCAAGTGTATGCA
GCAAATGAGGATCATAACTCTCAGTTTATTGATGATTATTCATCCTCAGATGAGAGTTTATCCGTCAGCCACTTCAGTTTCTCTAAACAG
AGCCACAGACCAAGAACTATAAGAGACAGAACTAGTTTTTCTTCAAAATTGCCTAGCCATAATAAGAAAAATAGCACTTTTATTCCAAGA
AAACCAATGAAATGTTCAAATGAGAAAGTTGTTAATCAAGAGCAGTCGTATGAATCAATGGATAAATTTTTAGATGGCGTTCAGGAAGTG
GCTTATATTCACTCAAACCAGAATGTAATTGGATCGAGCAAAGCTGAAAATCACATGAGCCGATGGGCAGCACATGACGTATTTGAGTTG
AAGCAGTTTTCTCAGCTGCCTGCTAACATAGCTGTTTGCAGTTCTAAGACATATAAAGAAAAAGTGGATGCAGATACATTGCCACACACA
AAGAAAGGCCAGCAACCGAGTGAAGGCAGCATTTCACTTCCTCTTTACATTTCAAATCCTGTAAACCAGAAGAAGAAAAAAGTCTACCAT
ACAAACCAGACCACCTTCATAATTGGAGAAACACCAAAAGGAATCCGCAGAGATGCTGCCTATGGAAGTTGCAATTTCTACATTACACTT
CTTGACTGTTTTCATGCAGTAAAGAAGGCAATGCAGTATGGCTTCCTTAATTTCAACTCATTTAACCTTGATGAATATGAACACTATGAA
AAAGCAGAAAATGGAGATTTAAATTGGATAATACCAGACCGATTTATTGCCTTCTGTGGACCTCATTCAAGAGCCAGACTTGAAAGTGGT
TACCACCAACATTCTCCTGAGACTTATATTCAATATTTTAAGAATCACAATGTTACTACCATTATTCGTCTGAATAAAAGGATGTATGAT
GCCAAACGCTTTACGGATGCTGGCTTCGATCACCATGATCTTTTCTTTGCGGATGGCAGCACCCCTACTGATGCCATTGTCAAAGAATTC
CTAGATATCTGTGAAAATGCTGAGGGTGCCATTGCAGTACATTGCAAAGCTGGCCTTGGTCGCACGGGCACTCTGATAGCCTGCTACATC
ATGAAGCATTACAGGATGACAGCAGCCGAGACCATTGCGTGGGTCAGGATCTGCAGACCTGGCTCGGTGATTGGGCCTCAGCAGCAGTTT
TTGGTGATGAAGCAAACCAACCTCTGGCTGGAAGGGGACTATTTTCGTCAGAAGTTAAAGGGGCAGGAGAATGGACAACACAGAGCAGCC
TTCTCCAAACTTCTCTCTGGCGTTGATGACATTTCCATAAATGGGGTCGAGAATCAAGATCAGCAAGAACCCGAACCGTACAGTGATGAT
GACGAAATCAATGGAGTGACACAAGGTGATAGACTTCGGGCCTTGAAAAGCAGAAGACAATCCAAAACAAACGCTATTCCTCTCACATGT
CCCCTAGCTGTGCTGACCTCTGCACTGTGTAGTGTTGTCATCTGGTGGATTGTTTGTGACTACATTCTTCCCATCCTGCTATTCTGTCTC
GATGGTTTCAGAACACAGTAGCCATCAGGACCCCCTGACAGATAGCTGCTTCTCTCCATTTCAAGGACTAAAACAGTCTTGCGTTAAGTA
AAAACCTGTGACCAGAGCTGAAGGAAGACTCTAGGACTGAAAACTGCAACAGAAATTAGCACAATTTGAAAACAAAACAAAATTGCAAAA
GCCTTAGTTGCTTTTTCCACCTAAGAAGTTGATCAATGGAGAAAATGTCCACTGGAGTTTGAATAATGAACTTTGAGTTTGGGTGCAAGC

>27319_27319_6_ERCC6L2-CDC14B_ERCC6L2_chr9_98766983_ENST00000407474_CDC14B_chr9_99304174_ENST00000463569_length(amino acids)=620AA_BP=293
MEGSEDSETEHTVKTRNNDNSRNTDDKRNGIISKKLSPENTTLKSILKRKGTSDISDESDDIEISSKSRVRKRASSLRFKRIKETKKELH
NSPKTMNKTNQVYAANEDHNSQFIDDYSSSDESLSVSHFSFSKQSHRPRTIRDRTSFSSKLPSHNKKNSTFIPRKPMKCSNEKVVNQEQS
YESMDKFLDGVQEVAYIHSNQNVIGSSKAENHMSRWAAHDVFELKQFSQLPANIAVCSSKTYKEKVDADTLPHTKKGQQPSEGSISLPLY
ISNPVNQKKKKVYHTNQTTFIIGETPKGIRRDAAYGSCNFYITLLDCFHAVKKAMQYGFLNFNSFNLDEYEHYEKAENGDLNWIIPDRFI
AFCGPHSRARLESGYHQHSPETYIQYFKNHNVTTIIRLNKRMYDAKRFTDAGFDHHDLFFADGSTPTDAIVKEFLDICENAEGAIAVHCK
AGLGRTGTLIACYIMKHYRMTAAETIAWVRICRPGSVIGPQQQFLVMKQTNLWLEGDYFRQKLKGQENGQHRAAFSKLLSGVDDISINGV

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Fusion Gene PPI Analysis for ERCC6L2-CDC14B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ERCC6L2-CDC14B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ERCC6L2-CDC14B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource