FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:ERG-APP (FusionGDB2 ID:27334)

Fusion Gene Summary for ERG-APP

check button Fusion gene summary
Fusion gene informationFusion gene name: ERG-APP
Fusion gene ID: 27334
HgeneTgene
Gene symbol

ERG

APP

Gene ID

2078

351

Gene nameETS transcription factor ERGamyloid beta precursor protein
Synonymserg-3|p55AAA|ABETA|ABPP|AD1|APPI|CTFgamma|CVAP|PN-II|PN2|preA4
Cytomap

21q22.2

21q21.3

Type of geneprotein-codingprotein-coding
Descriptiontranscriptional regulator ERGERG, ETS transcription factorFUS/ERG fusion proteinTMPRSS2/ERG fusionerythroblast transformation-specific transcription factor ERG variant 10ets-relatedtranscriptional regulator ERG (transforming protein ERG)v-ets avianamyloid-beta precursor proteinalzheimer disease amyloid proteinamyloid beta (A4) precursor proteinamyloid beta A4 proteinamyloid precursor proteinbeta-amyloid peptidebeta-amyloid peptide(1-40)beta-amyloid peptide(1-42)beta-amyloid precursor protei
Modification date2020032020200329
UniProtAcc.

Q8NEU8

Ensembl transtripts involved in fusion geneENST00000288319, ENST00000398905, 
ENST00000398907, ENST00000429727, 
ENST00000398910, ENST00000417133, 
ENST00000442448, ENST00000453032, 
ENST00000485493, ENST00000398897, 
ENST00000398911, ENST00000398919, 
ENST00000440126, ENST00000448388, 
ENST00000474136, ENST00000348990, 
ENST00000354192, ENST00000357903, 
ENST00000358918, ENST00000359726, 
ENST00000439274, ENST00000346798, 
Fusion gene scores* DoF score19 X 16 X 5=152025 X 18 X 10=4500
# samples 3127
** MAII scorelog2(31/1520*10)=-2.29373120305671
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(27/4500*10)=-4.05889368905357
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ERG [Title/Abstract] AND APP [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointERG(39870286)-APP(27484463), # samples:1
ERG(40033582)-APP(27484463), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneERG

GO:0045944

positive regulation of transcription by RNA polymerase II

18195090|23913826

TgeneAPP

GO:0001934

positive regulation of protein phosphorylation

11404397

TgeneAPP

GO:0008285

negative regulation of cell proliferation

22944668

TgeneAPP

GO:1905606

regulation of presynapse assembly

19726636


check buttonFusion gene breakpoints across ERG (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across APP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CD-8530-01AERGchr21

40033582

-APPchr21

27484463

-
ChimerDB4STADTCGA-D7-A4Z0ERGchr21

39870286

-APPchr21

27484463

-


Top

Fusion Gene ORF analysis for ERG-APP

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000288319ENST00000440126ERGchr21

39870286

-APPchr21

27484463

-
5CDS-5UTRENST00000288319ENST00000448388ERGchr21

39870286

-APPchr21

27484463

-
5CDS-5UTRENST00000288319ENST00000474136ERGchr21

39870286

-APPchr21

27484463

-
5CDS-5UTRENST00000398905ENST00000440126ERGchr21

39870286

-APPchr21

27484463

-
5CDS-5UTRENST00000398905ENST00000448388ERGchr21

39870286

-APPchr21

27484463

-
5CDS-5UTRENST00000398905ENST00000474136ERGchr21

39870286

-APPchr21

27484463

-
5CDS-5UTRENST00000398907ENST00000440126ERGchr21

39870286

-APPchr21

27484463

-
5CDS-5UTRENST00000398907ENST00000448388ERGchr21

39870286

-APPchr21

27484463

-
5CDS-5UTRENST00000398907ENST00000474136ERGchr21

39870286

-APPchr21

27484463

-
5CDS-5UTRENST00000429727ENST00000440126ERGchr21

39870286

-APPchr21

27484463

-
5CDS-5UTRENST00000429727ENST00000448388ERGchr21

39870286

-APPchr21

27484463

-
5CDS-5UTRENST00000429727ENST00000474136ERGchr21

39870286

-APPchr21

27484463

-
5CDS-intronENST00000288319ENST00000348990ERGchr21

39870286

-APPchr21

27484463

-
5CDS-intronENST00000288319ENST00000354192ERGchr21

39870286

-APPchr21

27484463

-
5CDS-intronENST00000288319ENST00000357903ERGchr21

39870286

-APPchr21

27484463

-
5CDS-intronENST00000288319ENST00000358918ERGchr21

39870286

-APPchr21

27484463

-
5CDS-intronENST00000288319ENST00000359726ERGchr21

39870286

-APPchr21

27484463

-
5CDS-intronENST00000288319ENST00000439274ERGchr21

39870286

-APPchr21

27484463

-
5CDS-intronENST00000398905ENST00000348990ERGchr21

39870286

-APPchr21

27484463

-
5CDS-intronENST00000398905ENST00000354192ERGchr21

39870286

-APPchr21

27484463

-
5CDS-intronENST00000398905ENST00000357903ERGchr21

39870286

-APPchr21

27484463

-
5CDS-intronENST00000398905ENST00000358918ERGchr21

39870286

-APPchr21

27484463

-
5CDS-intronENST00000398905ENST00000359726ERGchr21

39870286

-APPchr21

27484463

-
5CDS-intronENST00000398905ENST00000439274ERGchr21

39870286

-APPchr21

27484463

-
5CDS-intronENST00000398907ENST00000348990ERGchr21

39870286

-APPchr21

27484463

-
5CDS-intronENST00000398907ENST00000354192ERGchr21

39870286

-APPchr21

27484463

-
5CDS-intronENST00000398907ENST00000357903ERGchr21

39870286

-APPchr21

27484463

-
5CDS-intronENST00000398907ENST00000358918ERGchr21

39870286

-APPchr21

27484463

-
5CDS-intronENST00000398907ENST00000359726ERGchr21

39870286

-APPchr21

27484463

-
5CDS-intronENST00000398907ENST00000439274ERGchr21

39870286

-APPchr21

27484463

-
5CDS-intronENST00000429727ENST00000348990ERGchr21

39870286

-APPchr21

27484463

-
5CDS-intronENST00000429727ENST00000354192ERGchr21

39870286

-APPchr21

27484463

-
5CDS-intronENST00000429727ENST00000357903ERGchr21

39870286

-APPchr21

27484463

-
5CDS-intronENST00000429727ENST00000358918ERGchr21

39870286

-APPchr21

27484463

-
5CDS-intronENST00000429727ENST00000359726ERGchr21

39870286

-APPchr21

27484463

-
5CDS-intronENST00000429727ENST00000439274ERGchr21

39870286

-APPchr21

27484463

-
5UTR-3CDSENST00000398910ENST00000346798ERGchr21

40033582

-APPchr21

27484463

-
5UTR-3CDSENST00000417133ENST00000346798ERGchr21

40033582

-APPchr21

27484463

-
5UTR-3CDSENST00000442448ENST00000346798ERGchr21

40033582

-APPchr21

27484463

-
5UTR-3CDSENST00000453032ENST00000346798ERGchr21

39870286

-APPchr21

27484463

-
5UTR-3CDSENST00000485493ENST00000346798ERGchr21

40033582

-APPchr21

27484463

-
5UTR-5UTRENST00000398910ENST00000440126ERGchr21

40033582

-APPchr21

27484463

-
5UTR-5UTRENST00000398910ENST00000448388ERGchr21

40033582

-APPchr21

27484463

-
5UTR-5UTRENST00000398910ENST00000474136ERGchr21

40033582

-APPchr21

27484463

-
5UTR-5UTRENST00000417133ENST00000440126ERGchr21

40033582

-APPchr21

27484463

-
5UTR-5UTRENST00000417133ENST00000448388ERGchr21

40033582

-APPchr21

27484463

-
5UTR-5UTRENST00000417133ENST00000474136ERGchr21

40033582

-APPchr21

27484463

-
5UTR-5UTRENST00000442448ENST00000440126ERGchr21

40033582

-APPchr21

27484463

-
5UTR-5UTRENST00000442448ENST00000448388ERGchr21

40033582

-APPchr21

27484463

-
5UTR-5UTRENST00000442448ENST00000474136ERGchr21

40033582

-APPchr21

27484463

-
5UTR-5UTRENST00000453032ENST00000440126ERGchr21

39870286

-APPchr21

27484463

-
5UTR-5UTRENST00000453032ENST00000448388ERGchr21

39870286

-APPchr21

27484463

-
5UTR-5UTRENST00000453032ENST00000474136ERGchr21

39870286

-APPchr21

27484463

-
5UTR-5UTRENST00000485493ENST00000440126ERGchr21

40033582

-APPchr21

27484463

-
5UTR-5UTRENST00000485493ENST00000448388ERGchr21

40033582

-APPchr21

27484463

-
5UTR-5UTRENST00000485493ENST00000474136ERGchr21

40033582

-APPchr21

27484463

-
5UTR-intronENST00000398910ENST00000348990ERGchr21

40033582

-APPchr21

27484463

-
5UTR-intronENST00000398910ENST00000354192ERGchr21

40033582

-APPchr21

27484463

-
5UTR-intronENST00000398910ENST00000357903ERGchr21

40033582

-APPchr21

27484463

-
5UTR-intronENST00000398910ENST00000358918ERGchr21

40033582

-APPchr21

27484463

-
5UTR-intronENST00000398910ENST00000359726ERGchr21

40033582

-APPchr21

27484463

-
5UTR-intronENST00000398910ENST00000439274ERGchr21

40033582

-APPchr21

27484463

-
5UTR-intronENST00000417133ENST00000348990ERGchr21

40033582

-APPchr21

27484463

-
5UTR-intronENST00000417133ENST00000354192ERGchr21

40033582

-APPchr21

27484463

-
5UTR-intronENST00000417133ENST00000357903ERGchr21

40033582

-APPchr21

27484463

-
5UTR-intronENST00000417133ENST00000358918ERGchr21

40033582

-APPchr21

27484463

-
5UTR-intronENST00000417133ENST00000359726ERGchr21

40033582

-APPchr21

27484463

-
5UTR-intronENST00000417133ENST00000439274ERGchr21

40033582

-APPchr21

27484463

-
5UTR-intronENST00000442448ENST00000348990ERGchr21

40033582

-APPchr21

27484463

-
5UTR-intronENST00000442448ENST00000354192ERGchr21

40033582

-APPchr21

27484463

-
5UTR-intronENST00000442448ENST00000357903ERGchr21

40033582

-APPchr21

27484463

-
5UTR-intronENST00000442448ENST00000358918ERGchr21

40033582

-APPchr21

27484463

-
5UTR-intronENST00000442448ENST00000359726ERGchr21

40033582

-APPchr21

27484463

-
5UTR-intronENST00000442448ENST00000439274ERGchr21

40033582

-APPchr21

27484463

-
5UTR-intronENST00000453032ENST00000348990ERGchr21

39870286

-APPchr21

27484463

-
5UTR-intronENST00000453032ENST00000354192ERGchr21

39870286

-APPchr21

27484463

-
5UTR-intronENST00000453032ENST00000357903ERGchr21

39870286

-APPchr21

27484463

-
5UTR-intronENST00000453032ENST00000358918ERGchr21

39870286

-APPchr21

27484463

-
5UTR-intronENST00000453032ENST00000359726ERGchr21

39870286

-APPchr21

27484463

-
5UTR-intronENST00000453032ENST00000439274ERGchr21

39870286

-APPchr21

27484463

-
5UTR-intronENST00000485493ENST00000348990ERGchr21

40033582

-APPchr21

27484463

-
5UTR-intronENST00000485493ENST00000354192ERGchr21

40033582

-APPchr21

27484463

-
5UTR-intronENST00000485493ENST00000357903ERGchr21

40033582

-APPchr21

27484463

-
5UTR-intronENST00000485493ENST00000358918ERGchr21

40033582

-APPchr21

27484463

-
5UTR-intronENST00000485493ENST00000359726ERGchr21

40033582

-APPchr21

27484463

-
5UTR-intronENST00000485493ENST00000439274ERGchr21

40033582

-APPchr21

27484463

-
In-frameENST00000288319ENST00000346798ERGchr21

39870286

-APPchr21

27484463

-
In-frameENST00000398905ENST00000346798ERGchr21

39870286

-APPchr21

27484463

-
In-frameENST00000398907ENST00000346798ERGchr21

39870286

-APPchr21

27484463

-
In-frameENST00000429727ENST00000346798ERGchr21

39870286

-APPchr21

27484463

-
intron-3CDSENST00000288319ENST00000346798ERGchr21

40033582

-APPchr21

27484463

-
intron-3CDSENST00000398897ENST00000346798ERGchr21

40033582

-APPchr21

27484463

-
intron-3CDSENST00000398897ENST00000346798ERGchr21

39870286

-APPchr21

27484463

-
intron-3CDSENST00000398905ENST00000346798ERGchr21

40033582

-APPchr21

27484463

-
intron-3CDSENST00000398907ENST00000346798ERGchr21

40033582

-APPchr21

27484463

-
intron-3CDSENST00000398910ENST00000346798ERGchr21

39870286

-APPchr21

27484463

-
intron-3CDSENST00000398911ENST00000346798ERGchr21

40033582

-APPchr21

27484463

-
intron-3CDSENST00000398911ENST00000346798ERGchr21

39870286

-APPchr21

27484463

-
intron-3CDSENST00000398919ENST00000346798ERGchr21

40033582

-APPchr21

27484463

-
intron-3CDSENST00000398919ENST00000346798ERGchr21

39870286

-APPchr21

27484463

-
intron-3CDSENST00000417133ENST00000346798ERGchr21

39870286

-APPchr21

27484463

-
intron-3CDSENST00000429727ENST00000346798ERGchr21

40033582

-APPchr21

27484463

-
intron-3CDSENST00000442448ENST00000346798ERGchr21

39870286

-APPchr21

27484463

-
intron-3CDSENST00000453032ENST00000346798ERGchr21

40033582

-APPchr21

27484463

-
intron-3CDSENST00000485493ENST00000346798ERGchr21

39870286

-APPchr21

27484463

-
intron-5UTRENST00000288319ENST00000440126ERGchr21

40033582

-APPchr21

27484463

-
intron-5UTRENST00000288319ENST00000448388ERGchr21

40033582

-APPchr21

27484463

-
intron-5UTRENST00000288319ENST00000474136ERGchr21

40033582

-APPchr21

27484463

-
intron-5UTRENST00000398897ENST00000440126ERGchr21

40033582

-APPchr21

27484463

-
intron-5UTRENST00000398897ENST00000440126ERGchr21

39870286

-APPchr21

27484463

-
intron-5UTRENST00000398897ENST00000448388ERGchr21

40033582

-APPchr21

27484463

-
intron-5UTRENST00000398897ENST00000448388ERGchr21

39870286

-APPchr21

27484463

-
intron-5UTRENST00000398897ENST00000474136ERGchr21

40033582

-APPchr21

27484463

-
intron-5UTRENST00000398897ENST00000474136ERGchr21

39870286

-APPchr21

27484463

-
intron-5UTRENST00000398905ENST00000440126ERGchr21

40033582

-APPchr21

27484463

-
intron-5UTRENST00000398905ENST00000448388ERGchr21

40033582

-APPchr21

27484463

-
intron-5UTRENST00000398905ENST00000474136ERGchr21

40033582

-APPchr21

27484463

-
intron-5UTRENST00000398907ENST00000440126ERGchr21

40033582

-APPchr21

27484463

-
intron-5UTRENST00000398907ENST00000448388ERGchr21

40033582

-APPchr21

27484463

-
intron-5UTRENST00000398907ENST00000474136ERGchr21

40033582

-APPchr21

27484463

-
intron-5UTRENST00000398910ENST00000440126ERGchr21

39870286

-APPchr21

27484463

-
intron-5UTRENST00000398910ENST00000448388ERGchr21

39870286

-APPchr21

27484463

-
intron-5UTRENST00000398910ENST00000474136ERGchr21

39870286

-APPchr21

27484463

-
intron-5UTRENST00000398911ENST00000440126ERGchr21

40033582

-APPchr21

27484463

-
intron-5UTRENST00000398911ENST00000440126ERGchr21

39870286

-APPchr21

27484463

-
intron-5UTRENST00000398911ENST00000448388ERGchr21

40033582

-APPchr21

27484463

-
intron-5UTRENST00000398911ENST00000448388ERGchr21

39870286

-APPchr21

27484463

-
intron-5UTRENST00000398911ENST00000474136ERGchr21

40033582

-APPchr21

27484463

-
intron-5UTRENST00000398911ENST00000474136ERGchr21

39870286

-APPchr21

27484463

-
intron-5UTRENST00000398919ENST00000440126ERGchr21

40033582

-APPchr21

27484463

-
intron-5UTRENST00000398919ENST00000440126ERGchr21

39870286

-APPchr21

27484463

-
intron-5UTRENST00000398919ENST00000448388ERGchr21

40033582

-APPchr21

27484463

-
intron-5UTRENST00000398919ENST00000448388ERGchr21

39870286

-APPchr21

27484463

-
intron-5UTRENST00000398919ENST00000474136ERGchr21

40033582

-APPchr21

27484463

-
intron-5UTRENST00000398919ENST00000474136ERGchr21

39870286

-APPchr21

27484463

-
intron-5UTRENST00000417133ENST00000440126ERGchr21

39870286

-APPchr21

27484463

-
intron-5UTRENST00000417133ENST00000448388ERGchr21

39870286

-APPchr21

27484463

-
intron-5UTRENST00000417133ENST00000474136ERGchr21

39870286

-APPchr21

27484463

-
intron-5UTRENST00000429727ENST00000440126ERGchr21

40033582

-APPchr21

27484463

-
intron-5UTRENST00000429727ENST00000448388ERGchr21

40033582

-APPchr21

27484463

-
intron-5UTRENST00000429727ENST00000474136ERGchr21

40033582

-APPchr21

27484463

-
intron-5UTRENST00000442448ENST00000440126ERGchr21

39870286

-APPchr21

27484463

-
intron-5UTRENST00000442448ENST00000448388ERGchr21

39870286

-APPchr21

27484463

-
intron-5UTRENST00000442448ENST00000474136ERGchr21

39870286

-APPchr21

27484463

-
intron-5UTRENST00000453032ENST00000440126ERGchr21

40033582

-APPchr21

27484463

-
intron-5UTRENST00000453032ENST00000448388ERGchr21

40033582

-APPchr21

27484463

-
intron-5UTRENST00000453032ENST00000474136ERGchr21

40033582

-APPchr21

27484463

-
intron-5UTRENST00000485493ENST00000440126ERGchr21

39870286

-APPchr21

27484463

-
intron-5UTRENST00000485493ENST00000448388ERGchr21

39870286

-APPchr21

27484463

-
intron-5UTRENST00000485493ENST00000474136ERGchr21

39870286

-APPchr21

27484463

-
intron-intronENST00000288319ENST00000348990ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000288319ENST00000354192ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000288319ENST00000357903ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000288319ENST00000358918ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000288319ENST00000359726ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000288319ENST00000439274ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000398897ENST00000348990ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000398897ENST00000348990ERGchr21

39870286

-APPchr21

27484463

-
intron-intronENST00000398897ENST00000354192ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000398897ENST00000354192ERGchr21

39870286

-APPchr21

27484463

-
intron-intronENST00000398897ENST00000357903ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000398897ENST00000357903ERGchr21

39870286

-APPchr21

27484463

-
intron-intronENST00000398897ENST00000358918ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000398897ENST00000358918ERGchr21

39870286

-APPchr21

27484463

-
intron-intronENST00000398897ENST00000359726ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000398897ENST00000359726ERGchr21

39870286

-APPchr21

27484463

-
intron-intronENST00000398897ENST00000439274ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000398897ENST00000439274ERGchr21

39870286

-APPchr21

27484463

-
intron-intronENST00000398905ENST00000348990ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000398905ENST00000354192ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000398905ENST00000357903ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000398905ENST00000358918ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000398905ENST00000359726ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000398905ENST00000439274ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000398907ENST00000348990ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000398907ENST00000354192ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000398907ENST00000357903ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000398907ENST00000358918ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000398907ENST00000359726ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000398907ENST00000439274ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000398910ENST00000348990ERGchr21

39870286

-APPchr21

27484463

-
intron-intronENST00000398910ENST00000354192ERGchr21

39870286

-APPchr21

27484463

-
intron-intronENST00000398910ENST00000357903ERGchr21

39870286

-APPchr21

27484463

-
intron-intronENST00000398910ENST00000358918ERGchr21

39870286

-APPchr21

27484463

-
intron-intronENST00000398910ENST00000359726ERGchr21

39870286

-APPchr21

27484463

-
intron-intronENST00000398910ENST00000439274ERGchr21

39870286

-APPchr21

27484463

-
intron-intronENST00000398911ENST00000348990ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000398911ENST00000348990ERGchr21

39870286

-APPchr21

27484463

-
intron-intronENST00000398911ENST00000354192ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000398911ENST00000354192ERGchr21

39870286

-APPchr21

27484463

-
intron-intronENST00000398911ENST00000357903ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000398911ENST00000357903ERGchr21

39870286

-APPchr21

27484463

-
intron-intronENST00000398911ENST00000358918ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000398911ENST00000358918ERGchr21

39870286

-APPchr21

27484463

-
intron-intronENST00000398911ENST00000359726ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000398911ENST00000359726ERGchr21

39870286

-APPchr21

27484463

-
intron-intronENST00000398911ENST00000439274ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000398911ENST00000439274ERGchr21

39870286

-APPchr21

27484463

-
intron-intronENST00000398919ENST00000348990ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000398919ENST00000348990ERGchr21

39870286

-APPchr21

27484463

-
intron-intronENST00000398919ENST00000354192ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000398919ENST00000354192ERGchr21

39870286

-APPchr21

27484463

-
intron-intronENST00000398919ENST00000357903ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000398919ENST00000357903ERGchr21

39870286

-APPchr21

27484463

-
intron-intronENST00000398919ENST00000358918ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000398919ENST00000358918ERGchr21

39870286

-APPchr21

27484463

-
intron-intronENST00000398919ENST00000359726ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000398919ENST00000359726ERGchr21

39870286

-APPchr21

27484463

-
intron-intronENST00000398919ENST00000439274ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000398919ENST00000439274ERGchr21

39870286

-APPchr21

27484463

-
intron-intronENST00000417133ENST00000348990ERGchr21

39870286

-APPchr21

27484463

-
intron-intronENST00000417133ENST00000354192ERGchr21

39870286

-APPchr21

27484463

-
intron-intronENST00000417133ENST00000357903ERGchr21

39870286

-APPchr21

27484463

-
intron-intronENST00000417133ENST00000358918ERGchr21

39870286

-APPchr21

27484463

-
intron-intronENST00000417133ENST00000359726ERGchr21

39870286

-APPchr21

27484463

-
intron-intronENST00000417133ENST00000439274ERGchr21

39870286

-APPchr21

27484463

-
intron-intronENST00000429727ENST00000348990ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000429727ENST00000354192ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000429727ENST00000357903ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000429727ENST00000358918ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000429727ENST00000359726ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000429727ENST00000439274ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000442448ENST00000348990ERGchr21

39870286

-APPchr21

27484463

-
intron-intronENST00000442448ENST00000354192ERGchr21

39870286

-APPchr21

27484463

-
intron-intronENST00000442448ENST00000357903ERGchr21

39870286

-APPchr21

27484463

-
intron-intronENST00000442448ENST00000358918ERGchr21

39870286

-APPchr21

27484463

-
intron-intronENST00000442448ENST00000359726ERGchr21

39870286

-APPchr21

27484463

-
intron-intronENST00000442448ENST00000439274ERGchr21

39870286

-APPchr21

27484463

-
intron-intronENST00000453032ENST00000348990ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000453032ENST00000354192ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000453032ENST00000357903ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000453032ENST00000358918ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000453032ENST00000359726ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000453032ENST00000439274ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000485493ENST00000348990ERGchr21

39870286

-APPchr21

27484463

-
intron-intronENST00000485493ENST00000354192ERGchr21

39870286

-APPchr21

27484463

-
intron-intronENST00000485493ENST00000357903ERGchr21

39870286

-APPchr21

27484463

-
intron-intronENST00000485493ENST00000358918ERGchr21

39870286

-APPchr21

27484463

-
intron-intronENST00000485493ENST00000359726ERGchr21

39870286

-APPchr21

27484463

-
intron-intronENST00000485493ENST00000439274ERGchr21

39870286

-APPchr21

27484463

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000398907ERGchr2139870286-ENST00000346798APPchr2127484463-345680622335757
ENST00000398905ERGchr2139870286-ENST00000346798APPchr2127484463-345680622335757
ENST00000288319ERGchr2139870286-ENST00000346798APPchr2127484463-34971211032376757
ENST00000429727ERGchr2139870286-ENST00000346798APPchr2127484463-343559412314757

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000398907ENST00000346798ERGchr2139870286-APPchr2127484463-0.0024018260.99759823
ENST00000398905ENST00000346798ERGchr2139870286-APPchr2127484463-0.0024018260.99759823
ENST00000288319ENST00000346798ERGchr2139870286-APPchr2127484463-0.0024499890.9975501
ENST00000429727ENST00000346798ERGchr2139870286-APPchr2127484463-0.0023895160.99761045

Top

Fusion Genomic Features for ERG-APP


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for ERG-APP


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr21:39870286/chr21:27484463)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.APP

Q8NEU8

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Multifunctional adapter protein that binds to various membrane receptors, nuclear factors and signaling proteins to regulate many processes, such as cell proliferation, immune response, endosomal trafficking and cell metabolism (PubMed:26583432, PubMed:15016378, PubMed:24879834). Regulates signaling pathway leading to cell proliferation through interaction with RAB5A and subunits of the NuRD/MeCP1 complex (PubMed:15016378). Plays a role in immune response by modulating phagocytosis, inflammatory and innate immune responses. In macrophages, enhances Fc-gamma receptor-mediated phagocytosis through interaction with RAB31 leading to activation of PI3K/Akt signaling. In response to LPS, modulates inflammatory responses by playing a key role on the regulation of TLR4 signaling and in the nuclear translocation of RELA/NF-kappa-B p65 and the secretion of pro- and anti-inflammatory cytokines. Also functions as a negative regulator of innate immune response via inhibition of AKT1 signaling pathway by forming a complex with APPL1 and PIK3R1 (By similarity). Plays a role in endosomal trafficking of TGFBR1 from the endosomes to the nucleus (PubMed:26583432). Plays a role in cell metabolism by regulating adiponecting ans insulin signaling pathways and adaptative thermogenesis (PubMed:24879834) (By similarity). In muscle, negatively regulates adiponectin-simulated glucose uptake and fatty acid oxidation by inhibiting adiponectin signaling pathway through APPL1 sequestration thereby antagonizing APPL1 action (By similarity). In muscles, negativeliy regulates insulin-induced plasma membrane recruitment of GLUT4 and glucose uptake through interaction with TBC1D1 (PubMed:24879834). Plays a role in cold and diet-induced adaptive thermogenesis by activating ventromedial hypothalamus (VMH) neurons throught AMPK inhibition which enhances sympathetic outflow to subcutaneous white adipose tissue (sWAT), sWAT beiging and cold tolerance (By similarity). Also plays a role in other signaling pathways namely Wnt/beta-catenin, HGF and glucocorticoid receptor signaling (PubMed:19433865) (By similarity). Positive regulator of beta-catenin/TCF-dependent transcription through direct interaction with RUVBL2/reptin resulting in the relief of RUVBL2-mediated repression of beta-catenin/TCF target genes by modulating the interactions within the beta-catenin-reptin-HDAC complex (PubMed:19433865). May affect adult neurogenesis in hippocampus and olfactory system via regulating the sensitivity of glucocorticoid receptor. Required for fibroblast migration through HGF cell signaling (By similarity). {ECO:0000250|UniProtKB:Q8K3G9, ECO:0000269|PubMed:15016378, ECO:0000269|PubMed:19433865, ECO:0000269|PubMed:24879834, ECO:0000269|PubMed:26583432}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneAPPchr21:39870286chr21:27484463ENST00000346798018230_26019771.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneAPPchr21:39870286chr21:27484463ENST00000346798018274_28019771.0Compositional biasNote=Poly-Thr
TgeneAPPchr21:39870286chr21:27484463ENST00000348990016230_26019696.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneAPPchr21:39870286chr21:27484463ENST00000348990016274_28019696.0Compositional biasNote=Poly-Thr
TgeneAPPchr21:39870286chr21:27484463ENST00000354192015230_2600640.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneAPPchr21:39870286chr21:27484463ENST00000354192015274_2800640.0Compositional biasNote=Poly-Thr
TgeneAPPchr21:39870286chr21:27484463ENST00000357903017230_26019752.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneAPPchr21:39870286chr21:27484463ENST00000357903017274_28019752.0Compositional biasNote=Poly-Thr
TgeneAPPchr21:39870286chr21:27484463ENST00000358918017230_26019753.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneAPPchr21:39870286chr21:27484463ENST00000358918017274_28019753.0Compositional biasNote=Poly-Thr
TgeneAPPchr21:39870286chr21:27484463ENST00000359726017230_26019715.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneAPPchr21:39870286chr21:27484463ENST00000359726017274_28019715.0Compositional biasNote=Poly-Thr
TgeneAPPchr21:39870286chr21:27484463ENST00000440126017230_26014747.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneAPPchr21:39870286chr21:27484463ENST00000440126017274_28014747.0Compositional biasNote=Poly-Thr
TgeneAPPchr21:39870286chr21:27484463ENST0000034679801828_18919771.0DomainE1
TgeneAPPchr21:39870286chr21:27484463ENST00000346798018374_56519771.0DomainE2
TgeneAPPchr21:39870286chr21:27484463ENST0000034899001628_18919696.0DomainE1
TgeneAPPchr21:39870286chr21:27484463ENST00000348990016374_56519696.0DomainE2
TgeneAPPchr21:39870286chr21:27484463ENST0000035419201528_1890640.0DomainE1
TgeneAPPchr21:39870286chr21:27484463ENST00000354192015374_5650640.0DomainE2
TgeneAPPchr21:39870286chr21:27484463ENST0000035790301728_18919752.0DomainE1
TgeneAPPchr21:39870286chr21:27484463ENST00000357903017374_56519752.0DomainE2
TgeneAPPchr21:39870286chr21:27484463ENST0000035891801728_18919753.0DomainE1
TgeneAPPchr21:39870286chr21:27484463ENST00000358918017374_56519753.0DomainE2
TgeneAPPchr21:39870286chr21:27484463ENST0000035972601728_18919715.0DomainE1
TgeneAPPchr21:39870286chr21:27484463ENST00000359726017374_56519715.0DomainE2
TgeneAPPchr21:39870286chr21:27484463ENST0000044012601728_18914747.0DomainE1
TgeneAPPchr21:39870286chr21:27484463ENST00000440126017374_56514747.0DomainE2
TgeneAPPchr21:39870286chr21:27484463ENST00000346798018344_36519771.0MotifOX-2
TgeneAPPchr21:39870286chr21:27484463ENST00000346798018724_73419771.0MotifNote=Basolateral sorting signal
TgeneAPPchr21:39870286chr21:27484463ENST00000348990016344_36519696.0MotifOX-2
TgeneAPPchr21:39870286chr21:27484463ENST00000348990016724_73419696.0MotifNote=Basolateral sorting signal
TgeneAPPchr21:39870286chr21:27484463ENST00000354192015344_3650640.0MotifOX-2
TgeneAPPchr21:39870286chr21:27484463ENST00000354192015724_7340640.0MotifNote=Basolateral sorting signal
TgeneAPPchr21:39870286chr21:27484463ENST00000357903017344_36519752.0MotifOX-2
TgeneAPPchr21:39870286chr21:27484463ENST00000357903017724_73419752.0MotifNote=Basolateral sorting signal
TgeneAPPchr21:39870286chr21:27484463ENST00000358918017344_36519753.0MotifOX-2
TgeneAPPchr21:39870286chr21:27484463ENST00000358918017724_73419753.0MotifNote=Basolateral sorting signal
TgeneAPPchr21:39870286chr21:27484463ENST00000359726017344_36519715.0MotifOX-2
TgeneAPPchr21:39870286chr21:27484463ENST00000359726017724_73419715.0MotifNote=Basolateral sorting signal
TgeneAPPchr21:39870286chr21:27484463ENST00000440126017344_36514747.0MotifOX-2
TgeneAPPchr21:39870286chr21:27484463ENST00000440126017724_73414747.0MotifNote=Basolateral sorting signal
TgeneAPPchr21:39870286chr21:27484463ENST00000346798018131_18919771.0RegionCuBD subdomain
TgeneAPPchr21:39870286chr21:27484463ENST00000346798018181_18819771.0RegionNote=Zinc-binding
TgeneAPPchr21:39870286chr21:27484463ENST0000034679801828_12319771.0RegionGFLD subdomain
TgeneAPPchr21:39870286chr21:27484463ENST00000346798018391_42319771.0RegionNote=Heparin-binding
TgeneAPPchr21:39870286chr21:27484463ENST00000346798018491_52219771.0RegionNote=Heparin-binding
TgeneAPPchr21:39870286chr21:27484463ENST00000346798018523_54019771.0RegionCollagen-binding
TgeneAPPchr21:39870286chr21:27484463ENST0000034679801896_11019771.0RegionHeparin-binding
TgeneAPPchr21:39870286chr21:27484463ENST00000348990016131_18919696.0RegionCuBD subdomain
TgeneAPPchr21:39870286chr21:27484463ENST00000348990016181_18819696.0RegionNote=Zinc-binding
TgeneAPPchr21:39870286chr21:27484463ENST0000034899001628_12319696.0RegionGFLD subdomain
TgeneAPPchr21:39870286chr21:27484463ENST00000348990016391_42319696.0RegionNote=Heparin-binding
TgeneAPPchr21:39870286chr21:27484463ENST00000348990016491_52219696.0RegionNote=Heparin-binding
TgeneAPPchr21:39870286chr21:27484463ENST00000348990016523_54019696.0RegionCollagen-binding
TgeneAPPchr21:39870286chr21:27484463ENST0000034899001696_11019696.0RegionHeparin-binding
TgeneAPPchr21:39870286chr21:27484463ENST00000354192015131_1890640.0RegionCuBD subdomain
TgeneAPPchr21:39870286chr21:27484463ENST00000354192015181_1880640.0RegionNote=Zinc-binding
TgeneAPPchr21:39870286chr21:27484463ENST0000035419201528_1230640.0RegionGFLD subdomain
TgeneAPPchr21:39870286chr21:27484463ENST00000354192015391_4230640.0RegionNote=Heparin-binding
TgeneAPPchr21:39870286chr21:27484463ENST00000354192015491_5220640.0RegionNote=Heparin-binding
TgeneAPPchr21:39870286chr21:27484463ENST00000354192015523_5400640.0RegionCollagen-binding
TgeneAPPchr21:39870286chr21:27484463ENST0000035419201596_1100640.0RegionHeparin-binding
TgeneAPPchr21:39870286chr21:27484463ENST00000357903017131_18919752.0RegionCuBD subdomain
TgeneAPPchr21:39870286chr21:27484463ENST00000357903017181_18819752.0RegionNote=Zinc-binding
TgeneAPPchr21:39870286chr21:27484463ENST0000035790301728_12319752.0RegionGFLD subdomain
TgeneAPPchr21:39870286chr21:27484463ENST00000357903017391_42319752.0RegionNote=Heparin-binding
TgeneAPPchr21:39870286chr21:27484463ENST00000357903017491_52219752.0RegionNote=Heparin-binding
TgeneAPPchr21:39870286chr21:27484463ENST00000357903017523_54019752.0RegionCollagen-binding
TgeneAPPchr21:39870286chr21:27484463ENST0000035790301796_11019752.0RegionHeparin-binding
TgeneAPPchr21:39870286chr21:27484463ENST00000358918017131_18919753.0RegionCuBD subdomain
TgeneAPPchr21:39870286chr21:27484463ENST00000358918017181_18819753.0RegionNote=Zinc-binding
TgeneAPPchr21:39870286chr21:27484463ENST0000035891801728_12319753.0RegionGFLD subdomain
TgeneAPPchr21:39870286chr21:27484463ENST00000358918017391_42319753.0RegionNote=Heparin-binding
TgeneAPPchr21:39870286chr21:27484463ENST00000358918017491_52219753.0RegionNote=Heparin-binding
TgeneAPPchr21:39870286chr21:27484463ENST00000358918017523_54019753.0RegionCollagen-binding
TgeneAPPchr21:39870286chr21:27484463ENST0000035891801796_11019753.0RegionHeparin-binding
TgeneAPPchr21:39870286chr21:27484463ENST00000359726017131_18919715.0RegionCuBD subdomain
TgeneAPPchr21:39870286chr21:27484463ENST00000359726017181_18819715.0RegionNote=Zinc-binding
TgeneAPPchr21:39870286chr21:27484463ENST0000035972601728_12319715.0RegionGFLD subdomain
TgeneAPPchr21:39870286chr21:27484463ENST00000359726017391_42319715.0RegionNote=Heparin-binding
TgeneAPPchr21:39870286chr21:27484463ENST00000359726017491_52219715.0RegionNote=Heparin-binding
TgeneAPPchr21:39870286chr21:27484463ENST00000359726017523_54019715.0RegionCollagen-binding
TgeneAPPchr21:39870286chr21:27484463ENST0000035972601796_11019715.0RegionHeparin-binding
TgeneAPPchr21:39870286chr21:27484463ENST00000440126017131_18914747.0RegionCuBD subdomain
TgeneAPPchr21:39870286chr21:27484463ENST00000440126017181_18814747.0RegionNote=Zinc-binding
TgeneAPPchr21:39870286chr21:27484463ENST0000044012601728_12314747.0RegionGFLD subdomain
TgeneAPPchr21:39870286chr21:27484463ENST00000440126017391_42314747.0RegionNote=Heparin-binding
TgeneAPPchr21:39870286chr21:27484463ENST00000440126017491_52214747.0RegionNote=Heparin-binding
TgeneAPPchr21:39870286chr21:27484463ENST00000440126017523_54014747.0RegionCollagen-binding
TgeneAPPchr21:39870286chr21:27484463ENST0000044012601796_11014747.0RegionHeparin-binding
TgeneAPPchr21:39870286chr21:27484463ENST0000034679801818_70119771.0Topological domainExtracellular
TgeneAPPchr21:39870286chr21:27484463ENST00000346798018723_77019771.0Topological domainCytoplasmic
TgeneAPPchr21:39870286chr21:27484463ENST0000034899001618_70119696.0Topological domainExtracellular
TgeneAPPchr21:39870286chr21:27484463ENST00000348990016723_77019696.0Topological domainCytoplasmic
TgeneAPPchr21:39870286chr21:27484463ENST0000035419201518_7010640.0Topological domainExtracellular
TgeneAPPchr21:39870286chr21:27484463ENST00000354192015723_7700640.0Topological domainCytoplasmic
TgeneAPPchr21:39870286chr21:27484463ENST0000035790301718_70119752.0Topological domainExtracellular
TgeneAPPchr21:39870286chr21:27484463ENST00000357903017723_77019752.0Topological domainCytoplasmic
TgeneAPPchr21:39870286chr21:27484463ENST0000035891801718_70119753.0Topological domainExtracellular
TgeneAPPchr21:39870286chr21:27484463ENST00000358918017723_77019753.0Topological domainCytoplasmic
TgeneAPPchr21:39870286chr21:27484463ENST0000035972601718_70119715.0Topological domainExtracellular
TgeneAPPchr21:39870286chr21:27484463ENST00000359726017723_77019715.0Topological domainCytoplasmic
TgeneAPPchr21:39870286chr21:27484463ENST0000044012601718_70114747.0Topological domainExtracellular
TgeneAPPchr21:39870286chr21:27484463ENST00000440126017723_77014747.0Topological domainCytoplasmic
TgeneAPPchr21:39870286chr21:27484463ENST00000346798018702_72219771.0TransmembraneHelical
TgeneAPPchr21:39870286chr21:27484463ENST00000348990016702_72219696.0TransmembraneHelical
TgeneAPPchr21:39870286chr21:27484463ENST00000354192015702_7220640.0TransmembraneHelical
TgeneAPPchr21:39870286chr21:27484463ENST00000357903017702_72219752.0TransmembraneHelical
TgeneAPPchr21:39870286chr21:27484463ENST00000358918017702_72219753.0TransmembraneHelical
TgeneAPPchr21:39870286chr21:27484463ENST00000359726017702_72219715.0TransmembraneHelical
TgeneAPPchr21:39870286chr21:27484463ENST00000440126017702_72214747.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneERGchr21:39870286chr21:27484463ENST00000288319-110311_3916480.0DNA bindingETS
HgeneERGchr21:39870286chr21:27484463ENST00000398897-19311_3910364.0DNA bindingETS
HgeneERGchr21:39870286chr21:27484463ENST00000398911-110311_3910463.0DNA bindingETS
HgeneERGchr21:39870286chr21:27484463ENST00000398919-112311_3910487.0DNA bindingETS
HgeneERGchr21:39870286chr21:27484463ENST00000417133-112311_3910487.0DNA bindingETS
HgeneERGchr21:39870286chr21:27484463ENST00000442448-111311_3910463.0DNA bindingETS
HgeneERGchr21:39870286chr21:27484463ENST00000453032-19311_3910388.0DNA bindingETS
HgeneERGchr21:39870286chr21:27484463ENST00000288319-110113_1996480.0DomainPNT
HgeneERGchr21:39870286chr21:27484463ENST00000398897-19113_1990364.0DomainPNT
HgeneERGchr21:39870286chr21:27484463ENST00000398911-110113_1990463.0DomainPNT
HgeneERGchr21:39870286chr21:27484463ENST00000398919-112113_1990487.0DomainPNT
HgeneERGchr21:39870286chr21:27484463ENST00000417133-112113_1990487.0DomainPNT
HgeneERGchr21:39870286chr21:27484463ENST00000442448-111113_1990463.0DomainPNT
HgeneERGchr21:39870286chr21:27484463ENST00000453032-19113_1990388.0DomainPNT


Top

Fusion Gene Sequence for ERG-APP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>27334_27334_1_ERG-APP_ERG_chr21_39870286_ENST00000288319_APP_chr21_27484463_ENST00000346798_length(transcript)=3497nt_BP=121nt
AATCTCATCCGCTCTAAACAACCTCATCAAAACTACTTTCTGGTCAGAGAGAAGCAATAATTATTATTAACATTTATTAACGATCAATAA
ACTTGATCGCATTATGGCCAGCACTATTAAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGG
CAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCAT
CCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAA
GCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGT
TCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAG
TGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACT
GGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGA
TGGGAGTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAAGAAGCCGATGATGACGAGGACGATGA
GGATGGTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGAGAGAACCACCAGCATTGCCACCACCACCACCACCAC
CACAGAGTCTGTGGAAGAGGTGGTTCGAGAGGTGTGCTCTGAACAAGCCGAGACGGGGCCGTGCCGAGCAATGATCTCCCGCTGGTACTT
TGATGTGACTGAAGGGAAGTGTGCCCCATTCTTTTACGGCGGATGTGGCGGCAACCGGAACAACTTTGACACAGAAGAGTACTGCATGGC
CGTGTGTGGCAGCGCCATGTCCCAAAGTTTACTCAAGACTACCCAGGAACCTCTTGCCCGAGATCCTGTTAAACTTCCTACAACAGCAGC
CAGTACCCCTGATGCCGTTGACAAGTATCTCGAGACACCTGGGGATGAGAATGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGA
GGCCAAGCACCGAGAGAGAATGTCCCAGGTCATGAGAGAATGGGAAGAGGCAGAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAA
GGCAGTTATCCAGCATTTCCAGGAGAAAGTGGAATCTTTGGAACAGGAAGCAGCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGC
CAGAGTGGAAGCCATGCTCAATGACCGCCGCCGCCTGGCCCTGGAGAACTACATCACCGCTCTGCAGGCTGTTCCTCCTCGGCCTCGTCA
CGTGTTCAATATGCTAAAGAAGTATGTCCGCGCAGAACAGAAGGACAGACAGCACACCCTAAAGCATTTCGAGCATGTGCGCATGGTGGA
TCCCAAGAAAGCCGCTCAGATCCGGTCCCAGGTTATGACACACCTCCGTGTGATTTATGAGCGCATGAATCAGTCTCTCTCCCTGCTCTA
CAACGTGCCTGCAGTGGCCGAGGAGATTCAGGATGAAGTTGATGAGCTGCTTCAGAAAGAGCAAAACTATTCAGATGACGTCTTGGCCAA
CATGATTAGTGAACCAAGGATCAGTTACGGAAACGATGCTCTCATGCCATCTTTGACCGAAACGAAAACCACCGTGGAGCTCCTTCCCGT
GAATGGAGAGTTCAGCCTGGACGATCTCCAGCCGTGGCATTCTTTTGGGGCTGACTCTGTGCCAGCCAACACAGAAAACGAAGTTGAGCC
TGTTGATGCCCGCCCTGCTGCCGACCGAGGACTGACCACTCGACCAGGTTCTGGGTTGACAAATATCAAGACGGAGGAGATCTCTGAAGT
GAAGATGGATGCAGAATTCCGACATGACTCAGGATATGAAGTTCATCATCAAAAATTGGTGTTCTTTGCAGAAGATGTGGGTTCAAACAA
AGGTGCAATCATTGGACTCATGGTGGGCGGTGTTGTCATAGCGACAGTGATCGTCATCACCTTGGTGATGCTGAAGAAGAAACAGTACAC
ATCCATTCATCATGGTGTGGTGGAGGTTGACGCCGCTGTCACCCCAGAGGAGCGCCACCTGTCCAAGATGCAGCAGAACGGCTACGAAAA
TCCAACCTACAAGTTCTTTGAGCAGATGCAGAACTAGACCCCCGCCACAGCAGCCTCTGAAGTTGGACAGCAAAACCATTGCTTCACTAC
CCATCGGTGTCCATTTATAGAATAATGTGGGAAGAAACAAACCCGTTTTATGATTTACTCATTATCGCCTTTTGACAGCTGTGCTGTAAC
ACAAGTAGATGCCTGAACTTGAATTAATCCACACATCAGTAATGTATTCTATCTCTCTTTACATTTTGGTCTCTATACTACATTATTAAT
GGGTTTTGTGTACTGTAAAGAATTTAGCTGTATCAAACTAGTGCATGAATAGATTCTCTCCTGATTATTTATCACATAGCCCCTTAGCCA
GTTGTATATTATTCTTGTGGTTTGTGACCCAATTAAGTCCTACTTTACATATGCTTTAAGAATCGATGGGGGATGCTTCATGTGAACGTG
GGAGTTCAGCTGCTTCTCTTGCCTAAGTATTCCTTTCCTGATCACTATGCATTTTAAAGTTAAACATTTTTAAGTATTTCAGATGCTTTA
GAGAGATTTTTTTTCCATGACTGCATTTTACTGTACAGATTGCTGCTTCTGCTATATTTGTGATATAGGAATTAAGAGGATACACACGTT
TGTTTCTTCGTGCCTGTTTTATGTGCACACATTAGGCATTGAGACTTCAAGCTTTTCTTTTTTTGTCCACGTATCTTTGGGTCTTTGATA
AAGAAAAGAATCCCTGTTCATTGTAAGCACTTTTACGGGGCGGGTGGGGAGGGGTGCTCTGCTGGTCTTCAATTACCAAGAATTCTCCAA
AACAATTTTCTGCAGGATGATTGTACAGAATCATTGCTTATGACATGATCGCTTTCTACACTGTATTACATAAATAAATTAAATAAAATA
ACCCCGGGCAAGACTTTTCTTTGAAGGATGACTACAGACATTAAATAATCGAAGTAATTTTGGGTGGGGAGAAGAGGCAGATTCAATTTT
CTTTAACCAGTCTGAAGTTTCATTTATGATACAAAAGAAGATGAAAATGGAAGTGGCAATATAAGGGGATGAGGAAGGCATGCCTGGACA

>27334_27334_1_ERG-APP_ERG_chr21_39870286_ENST00000288319_APP_chr21_27484463_ENST00000346798_length(amino acids)=757AA_BP=6
MASTIKVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRK
QCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEES
DNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESV
EEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAASTPD
AVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEA
MLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPA
VAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDAR
PAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHH

--------------------------------------------------------------
>27334_27334_2_ERG-APP_ERG_chr21_39870286_ENST00000398905_APP_chr21_27484463_ENST00000346798_length(transcript)=3456nt_BP=80nt
GGTCAGAGAGAAGCAATAATTATTATTAACATTTATTAACGATCAATAAACTTGATCGCATTATGGCCAGCACTATTAAGGTACCCACTG
ATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGG
ATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCA
CCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGA
TTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATG
TTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGC
CCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGG
AGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAG
AAGTGGCTGAGGTGGAAGAAGAAGAAGCCGATGATGACGAGGACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACG
AAGAAGCCACAGAGAGAACCACCAGCATTGCCACCACCACCACCACCACCACAGAGTCTGTGGAAGAGGTGGTTCGAGAGGTGTGCTCTG
AACAAGCCGAGACGGGGCCGTGCCGAGCAATGATCTCCCGCTGGTACTTTGATGTGACTGAAGGGAAGTGTGCCCCATTCTTTTACGGCG
GATGTGGCGGCAACCGGAACAACTTTGACACAGAAGAGTACTGCATGGCCGTGTGTGGCAGCGCCATGTCCCAAAGTTTACTCAAGACTA
CCCAGGAACCTCTTGCCCGAGATCCTGTTAAACTTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTCGAGACACCTG
GGGATGAGAATGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGTCATGAGAGAAT
GGGAAGAGGCAGAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGTGGAATCTTTGG
AACAGGAAGCAGCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCGCCGCCTGGCCC
TGGAGAACTACATCACCGCTCTGCAGGCTGTTCCTCCTCGGCCTCGTCACGTGTTCAATATGCTAAAGAAGTATGTCCGCGCAGAACAGA
AGGACAGACAGCACACCCTAAAGCATTTCGAGCATGTGCGCATGGTGGATCCCAAGAAAGCCGCTCAGATCCGGTCCCAGGTTATGACAC
ACCTCCGTGTGATTTATGAGCGCATGAATCAGTCTCTCTCCCTGCTCTACAACGTGCCTGCAGTGGCCGAGGAGATTCAGGATGAAGTTG
ATGAGCTGCTTCAGAAAGAGCAAAACTATTCAGATGACGTCTTGGCCAACATGATTAGTGAACCAAGGATCAGTTACGGAAACGATGCTC
TCATGCCATCTTTGACCGAAACGAAAACCACCGTGGAGCTCCTTCCCGTGAATGGAGAGTTCAGCCTGGACGATCTCCAGCCGTGGCATT
CTTTTGGGGCTGACTCTGTGCCAGCCAACACAGAAAACGAAGTTGAGCCTGTTGATGCCCGCCCTGCTGCCGACCGAGGACTGACCACTC
GACCAGGTTCTGGGTTGACAAATATCAAGACGGAGGAGATCTCTGAAGTGAAGATGGATGCAGAATTCCGACATGACTCAGGATATGAAG
TTCATCATCAAAAATTGGTGTTCTTTGCAGAAGATGTGGGTTCAAACAAAGGTGCAATCATTGGACTCATGGTGGGCGGTGTTGTCATAG
CGACAGTGATCGTCATCACCTTGGTGATGCTGAAGAAGAAACAGTACACATCCATTCATCATGGTGTGGTGGAGGTTGACGCCGCTGTCA
CCCCAGAGGAGCGCCACCTGTCCAAGATGCAGCAGAACGGCTACGAAAATCCAACCTACAAGTTCTTTGAGCAGATGCAGAACTAGACCC
CCGCCACAGCAGCCTCTGAAGTTGGACAGCAAAACCATTGCTTCACTACCCATCGGTGTCCATTTATAGAATAATGTGGGAAGAAACAAA
CCCGTTTTATGATTTACTCATTATCGCCTTTTGACAGCTGTGCTGTAACACAAGTAGATGCCTGAACTTGAATTAATCCACACATCAGTA
ATGTATTCTATCTCTCTTTACATTTTGGTCTCTATACTACATTATTAATGGGTTTTGTGTACTGTAAAGAATTTAGCTGTATCAAACTAG
TGCATGAATAGATTCTCTCCTGATTATTTATCACATAGCCCCTTAGCCAGTTGTATATTATTCTTGTGGTTTGTGACCCAATTAAGTCCT
ACTTTACATATGCTTTAAGAATCGATGGGGGATGCTTCATGTGAACGTGGGAGTTCAGCTGCTTCTCTTGCCTAAGTATTCCTTTCCTGA
TCACTATGCATTTTAAAGTTAAACATTTTTAAGTATTTCAGATGCTTTAGAGAGATTTTTTTTCCATGACTGCATTTTACTGTACAGATT
GCTGCTTCTGCTATATTTGTGATATAGGAATTAAGAGGATACACACGTTTGTTTCTTCGTGCCTGTTTTATGTGCACACATTAGGCATTG
AGACTTCAAGCTTTTCTTTTTTTGTCCACGTATCTTTGGGTCTTTGATAAAGAAAAGAATCCCTGTTCATTGTAAGCACTTTTACGGGGC
GGGTGGGGAGGGGTGCTCTGCTGGTCTTCAATTACCAAGAATTCTCCAAAACAATTTTCTGCAGGATGATTGTACAGAATCATTGCTTAT
GACATGATCGCTTTCTACACTGTATTACATAAATAAATTAAATAAAATAACCCCGGGCAAGACTTTTCTTTGAAGGATGACTACAGACAT
TAAATAATCGAAGTAATTTTGGGTGGGGAGAAGAGGCAGATTCAATTTTCTTTAACCAGTCTGAAGTTTCATTTATGATACAAAAGAAGA
TGAAAATGGAAGTGGCAATATAAGGGGATGAGGAAGGCATGCCTGGACAAACCCTTCTTTTAAGATGTGTCTTCAATTTGTATAAAATGG

>27334_27334_2_ERG-APP_ERG_chr21_39870286_ENST00000398905_APP_chr21_27484463_ENST00000346798_length(amino acids)=757AA_BP=6
MASTIKVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRK
QCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEES
DNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESV
EEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAASTPD
AVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEA
MLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPA
VAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDAR
PAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHH

--------------------------------------------------------------
>27334_27334_3_ERG-APP_ERG_chr21_39870286_ENST00000398907_APP_chr21_27484463_ENST00000346798_length(transcript)=3456nt_BP=80nt
GGTCAGAGAGAAGCAATAATTATTATTAACATTTATTAACGATCAATAAACTTGATCGCATTATGGCCAGCACTATTAAGGTACCCACTG
ATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGG
ATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCA
CCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGA
TTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATG
TTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGC
CCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGG
AGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAG
AAGTGGCTGAGGTGGAAGAAGAAGAAGCCGATGATGACGAGGACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACG
AAGAAGCCACAGAGAGAACCACCAGCATTGCCACCACCACCACCACCACCACAGAGTCTGTGGAAGAGGTGGTTCGAGAGGTGTGCTCTG
AACAAGCCGAGACGGGGCCGTGCCGAGCAATGATCTCCCGCTGGTACTTTGATGTGACTGAAGGGAAGTGTGCCCCATTCTTTTACGGCG
GATGTGGCGGCAACCGGAACAACTTTGACACAGAAGAGTACTGCATGGCCGTGTGTGGCAGCGCCATGTCCCAAAGTTTACTCAAGACTA
CCCAGGAACCTCTTGCCCGAGATCCTGTTAAACTTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTCGAGACACCTG
GGGATGAGAATGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGTCATGAGAGAAT
GGGAAGAGGCAGAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGTGGAATCTTTGG
AACAGGAAGCAGCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCGCCGCCTGGCCC
TGGAGAACTACATCACCGCTCTGCAGGCTGTTCCTCCTCGGCCTCGTCACGTGTTCAATATGCTAAAGAAGTATGTCCGCGCAGAACAGA
AGGACAGACAGCACACCCTAAAGCATTTCGAGCATGTGCGCATGGTGGATCCCAAGAAAGCCGCTCAGATCCGGTCCCAGGTTATGACAC
ACCTCCGTGTGATTTATGAGCGCATGAATCAGTCTCTCTCCCTGCTCTACAACGTGCCTGCAGTGGCCGAGGAGATTCAGGATGAAGTTG
ATGAGCTGCTTCAGAAAGAGCAAAACTATTCAGATGACGTCTTGGCCAACATGATTAGTGAACCAAGGATCAGTTACGGAAACGATGCTC
TCATGCCATCTTTGACCGAAACGAAAACCACCGTGGAGCTCCTTCCCGTGAATGGAGAGTTCAGCCTGGACGATCTCCAGCCGTGGCATT
CTTTTGGGGCTGACTCTGTGCCAGCCAACACAGAAAACGAAGTTGAGCCTGTTGATGCCCGCCCTGCTGCCGACCGAGGACTGACCACTC
GACCAGGTTCTGGGTTGACAAATATCAAGACGGAGGAGATCTCTGAAGTGAAGATGGATGCAGAATTCCGACATGACTCAGGATATGAAG
TTCATCATCAAAAATTGGTGTTCTTTGCAGAAGATGTGGGTTCAAACAAAGGTGCAATCATTGGACTCATGGTGGGCGGTGTTGTCATAG
CGACAGTGATCGTCATCACCTTGGTGATGCTGAAGAAGAAACAGTACACATCCATTCATCATGGTGTGGTGGAGGTTGACGCCGCTGTCA
CCCCAGAGGAGCGCCACCTGTCCAAGATGCAGCAGAACGGCTACGAAAATCCAACCTACAAGTTCTTTGAGCAGATGCAGAACTAGACCC
CCGCCACAGCAGCCTCTGAAGTTGGACAGCAAAACCATTGCTTCACTACCCATCGGTGTCCATTTATAGAATAATGTGGGAAGAAACAAA
CCCGTTTTATGATTTACTCATTATCGCCTTTTGACAGCTGTGCTGTAACACAAGTAGATGCCTGAACTTGAATTAATCCACACATCAGTA
ATGTATTCTATCTCTCTTTACATTTTGGTCTCTATACTACATTATTAATGGGTTTTGTGTACTGTAAAGAATTTAGCTGTATCAAACTAG
TGCATGAATAGATTCTCTCCTGATTATTTATCACATAGCCCCTTAGCCAGTTGTATATTATTCTTGTGGTTTGTGACCCAATTAAGTCCT
ACTTTACATATGCTTTAAGAATCGATGGGGGATGCTTCATGTGAACGTGGGAGTTCAGCTGCTTCTCTTGCCTAAGTATTCCTTTCCTGA
TCACTATGCATTTTAAAGTTAAACATTTTTAAGTATTTCAGATGCTTTAGAGAGATTTTTTTTCCATGACTGCATTTTACTGTACAGATT
GCTGCTTCTGCTATATTTGTGATATAGGAATTAAGAGGATACACACGTTTGTTTCTTCGTGCCTGTTTTATGTGCACACATTAGGCATTG
AGACTTCAAGCTTTTCTTTTTTTGTCCACGTATCTTTGGGTCTTTGATAAAGAAAAGAATCCCTGTTCATTGTAAGCACTTTTACGGGGC
GGGTGGGGAGGGGTGCTCTGCTGGTCTTCAATTACCAAGAATTCTCCAAAACAATTTTCTGCAGGATGATTGTACAGAATCATTGCTTAT
GACATGATCGCTTTCTACACTGTATTACATAAATAAATTAAATAAAATAACCCCGGGCAAGACTTTTCTTTGAAGGATGACTACAGACAT
TAAATAATCGAAGTAATTTTGGGTGGGGAGAAGAGGCAGATTCAATTTTCTTTAACCAGTCTGAAGTTTCATTTATGATACAAAAGAAGA
TGAAAATGGAAGTGGCAATATAAGGGGATGAGGAAGGCATGCCTGGACAAACCCTTCTTTTAAGATGTGTCTTCAATTTGTATAAAATGG

>27334_27334_3_ERG-APP_ERG_chr21_39870286_ENST00000398907_APP_chr21_27484463_ENST00000346798_length(amino acids)=757AA_BP=6
MASTIKVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRK
QCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEES
DNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESV
EEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAASTPD
AVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEA
MLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPA
VAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDAR
PAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHH

--------------------------------------------------------------
>27334_27334_4_ERG-APP_ERG_chr21_39870286_ENST00000429727_APP_chr21_27484463_ENST00000346798_length(transcript)=3435nt_BP=59nt
ATTATTAACATTTATTAACGATCAATAAACTTGATCGCATTATGGCCAGCACTATTAAGGTACCCACTGATGGTAATGCTGGCCTGCTGG
CTGAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCA
AAACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACC
AACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTG
GTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACT
GGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCC
GAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGT
GGGGCGGAGCAGACACAGACTATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAG
AAGAAGCCGATGATGACGAGGACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGAGAGAACCA
CCAGCATTGCCACCACCACCACCACCACCACAGAGTCTGTGGAAGAGGTGGTTCGAGAGGTGTGCTCTGAACAAGCCGAGACGGGGCCGT
GCCGAGCAATGATCTCCCGCTGGTACTTTGATGTGACTGAAGGGAAGTGTGCCCCATTCTTTTACGGCGGATGTGGCGGCAACCGGAACA
ACTTTGACACAGAAGAGTACTGCATGGCCGTGTGTGGCAGCGCCATGTCCCAAAGTTTACTCAAGACTACCCAGGAACCTCTTGCCCGAG
ATCCTGTTAAACTTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTCGAGACACCTGGGGATGAGAATGAACATGCCC
ATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGTCATGAGAGAATGGGAAGAGGCAGAACGTCAAG
CAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGTGGAATCTTTGGAACAGGAAGCAGCCAACGAGA
GACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCGCCGCCTGGCCCTGGAGAACTACATCACCGCTC
TGCAGGCTGTTCCTCCTCGGCCTCGTCACGTGTTCAATATGCTAAAGAAGTATGTCCGCGCAGAACAGAAGGACAGACAGCACACCCTAA
AGCATTTCGAGCATGTGCGCATGGTGGATCCCAAGAAAGCCGCTCAGATCCGGTCCCAGGTTATGACACACCTCCGTGTGATTTATGAGC
GCATGAATCAGTCTCTCTCCCTGCTCTACAACGTGCCTGCAGTGGCCGAGGAGATTCAGGATGAAGTTGATGAGCTGCTTCAGAAAGAGC
AAAACTATTCAGATGACGTCTTGGCCAACATGATTAGTGAACCAAGGATCAGTTACGGAAACGATGCTCTCATGCCATCTTTGACCGAAA
CGAAAACCACCGTGGAGCTCCTTCCCGTGAATGGAGAGTTCAGCCTGGACGATCTCCAGCCGTGGCATTCTTTTGGGGCTGACTCTGTGC
CAGCCAACACAGAAAACGAAGTTGAGCCTGTTGATGCCCGCCCTGCTGCCGACCGAGGACTGACCACTCGACCAGGTTCTGGGTTGACAA
ATATCAAGACGGAGGAGATCTCTGAAGTGAAGATGGATGCAGAATTCCGACATGACTCAGGATATGAAGTTCATCATCAAAAATTGGTGT
TCTTTGCAGAAGATGTGGGTTCAAACAAAGGTGCAATCATTGGACTCATGGTGGGCGGTGTTGTCATAGCGACAGTGATCGTCATCACCT
TGGTGATGCTGAAGAAGAAACAGTACACATCCATTCATCATGGTGTGGTGGAGGTTGACGCCGCTGTCACCCCAGAGGAGCGCCACCTGT
CCAAGATGCAGCAGAACGGCTACGAAAATCCAACCTACAAGTTCTTTGAGCAGATGCAGAACTAGACCCCCGCCACAGCAGCCTCTGAAG
TTGGACAGCAAAACCATTGCTTCACTACCCATCGGTGTCCATTTATAGAATAATGTGGGAAGAAACAAACCCGTTTTATGATTTACTCAT
TATCGCCTTTTGACAGCTGTGCTGTAACACAAGTAGATGCCTGAACTTGAATTAATCCACACATCAGTAATGTATTCTATCTCTCTTTAC
ATTTTGGTCTCTATACTACATTATTAATGGGTTTTGTGTACTGTAAAGAATTTAGCTGTATCAAACTAGTGCATGAATAGATTCTCTCCT
GATTATTTATCACATAGCCCCTTAGCCAGTTGTATATTATTCTTGTGGTTTGTGACCCAATTAAGTCCTACTTTACATATGCTTTAAGAA
TCGATGGGGGATGCTTCATGTGAACGTGGGAGTTCAGCTGCTTCTCTTGCCTAAGTATTCCTTTCCTGATCACTATGCATTTTAAAGTTA
AACATTTTTAAGTATTTCAGATGCTTTAGAGAGATTTTTTTTCCATGACTGCATTTTACTGTACAGATTGCTGCTTCTGCTATATTTGTG
ATATAGGAATTAAGAGGATACACACGTTTGTTTCTTCGTGCCTGTTTTATGTGCACACATTAGGCATTGAGACTTCAAGCTTTTCTTTTT
TTGTCCACGTATCTTTGGGTCTTTGATAAAGAAAAGAATCCCTGTTCATTGTAAGCACTTTTACGGGGCGGGTGGGGAGGGGTGCTCTGC
TGGTCTTCAATTACCAAGAATTCTCCAAAACAATTTTCTGCAGGATGATTGTACAGAATCATTGCTTATGACATGATCGCTTTCTACACT
GTATTACATAAATAAATTAAATAAAATAACCCCGGGCAAGACTTTTCTTTGAAGGATGACTACAGACATTAAATAATCGAAGTAATTTTG
GGTGGGGAGAAGAGGCAGATTCAATTTTCTTTAACCAGTCTGAAGTTTCATTTATGATACAAAAGAAGATGAAAATGGAAGTGGCAATAT
AAGGGGATGAGGAAGGCATGCCTGGACAAACCCTTCTTTTAAGATGTGTCTTCAATTTGTATAAAATGGTGTTTTCATGTAAATAAATAC

>27334_27334_4_ERG-APP_ERG_chr21_39870286_ENST00000429727_APP_chr21_27484463_ENST00000346798_length(amino acids)=757AA_BP=6
MASTIKVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRK
QCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEES
DNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESV
EEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAASTPD
AVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEA
MLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPA
VAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDAR
PAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHH

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for ERG-APP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneAPPchr21:39870286chr21:27484463ENST00000346798018732_75119.0771.0G(o)-alpha
TgeneAPPchr21:39870286chr21:27484463ENST00000348990016732_75119.0696.0G(o)-alpha
TgeneAPPchr21:39870286chr21:27484463ENST00000354192015732_7510640.0G(o)-alpha
TgeneAPPchr21:39870286chr21:27484463ENST00000357903017732_75119.0752.0G(o)-alpha
TgeneAPPchr21:39870286chr21:27484463ENST00000358918017732_75119.0753.0G(o)-alpha
TgeneAPPchr21:39870286chr21:27484463ENST00000359726017732_75119.0715.0G(o)-alpha
TgeneAPPchr21:39870286chr21:27484463ENST00000440126017732_75114.0747.0G(o)-alpha
TgeneAPPchr21:39870286chr21:27484463ENST00000346798018695_72219.0771.0PSEN1
TgeneAPPchr21:39870286chr21:27484463ENST00000348990016695_72219.0696.0PSEN1
TgeneAPPchr21:39870286chr21:27484463ENST00000354192015695_7220640.0PSEN1
TgeneAPPchr21:39870286chr21:27484463ENST00000357903017695_72219.0752.0PSEN1
TgeneAPPchr21:39870286chr21:27484463ENST00000358918017695_72219.0753.0PSEN1
TgeneAPPchr21:39870286chr21:27484463ENST00000359726017695_72219.0715.0PSEN1
TgeneAPPchr21:39870286chr21:27484463ENST00000440126017695_72214.0747.0PSEN1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for ERG-APP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for ERG-APP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource