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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ERG-PLEKHH1 (FusionGDB2 ID:27373)

Fusion Gene Summary for ERG-PLEKHH1

Fusion gene summary

Fusion gene information	Fusion gene name: ERG-PLEKHH1
	Fusion gene ID: 27373
		Hgene	Tgene
	Gene symbol	ERG	PLEKHH1
	Gene ID	2078	57475
	Gene name	ETS transcription factor ERG	pleckstrin homology, MyTH4 and FERM domain containing H1
	Synonyms	erg-3\|p55	-
	Cytomap	21q22.2	14q24.1
	Type of gene	protein-coding	protein-coding
	Description	transcriptional regulator ERGERG, ETS transcription factorFUS/ERG fusion proteinTMPRSS2/ERG fusionerythroblast transformation-specific transcription factor ERG variant 10ets-relatedtranscriptional regulator ERG (transforming protein ERG)v-ets avian	pleckstrin homology domain-containing family H member 1PH domain-containing family H member 1pleckstrin homology domain containing, family H (with MyTH4 domain) member 1
	Modification date	20200320	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000398910, ENST00000398911, ENST00000398919, ENST00000417133, ENST00000442448, ENST00000398897, ENST00000485493, ENST00000288319, ENST00000398905, ENST00000398907, ENST00000429727, ENST00000453032,	ENST00000417684, ENST00000559832, ENST00000329153,
Fusion gene scores	* DoF score	19 X 16 X 5=1520	7 X 8 X 5=280
	# samples	31	9
	** MAII score	log2(31/1520*10)=-2.29373120305671 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(9/280*10)=-1.63742992061529 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ERG [Title/Abstract] AND PLEKHH1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ERG(39947586)-PLEKHH1(68022542), # samples:3
Anticipated loss of major functional domain due to fusion event.	ERG-PLEKHH1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. ERG-PLEKHH1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. ERG-PLEKHH1 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF. ERG-PLEKHH1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ERG	GO:0045944	positive regulation of transcription by RNA polymerase II	18195090\|23913826

Fusion gene breakpoints across ERG (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PLEKHH1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	PRAD	TCGA-CH-5739-01A	ERG	chr21	39947586	-	PLEKHH1	chr14	68022542	+
ChimerDB4	PRAD	TCGA-CH-5739	ERG	chr21	39947586	-	PLEKHH1	chr14	68022542	+

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Fusion Gene ORF analysis for ERG-PLEKHH1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000398910	ENST00000417684	ERG	chr21	39947586	-	PLEKHH1	chr14	68022542	+
5CDS-intron	ENST00000398910	ENST00000559832	ERG	chr21	39947586	-	PLEKHH1	chr14	68022542	+
5CDS-intron	ENST00000398911	ENST00000417684	ERG	chr21	39947586	-	PLEKHH1	chr14	68022542	+
5CDS-intron	ENST00000398911	ENST00000559832	ERG	chr21	39947586	-	PLEKHH1	chr14	68022542	+
5CDS-intron	ENST00000398919	ENST00000417684	ERG	chr21	39947586	-	PLEKHH1	chr14	68022542	+
5CDS-intron	ENST00000398919	ENST00000559832	ERG	chr21	39947586	-	PLEKHH1	chr14	68022542	+
5CDS-intron	ENST00000417133	ENST00000417684	ERG	chr21	39947586	-	PLEKHH1	chr14	68022542	+
5CDS-intron	ENST00000417133	ENST00000559832	ERG	chr21	39947586	-	PLEKHH1	chr14	68022542	+
5CDS-intron	ENST00000442448	ENST00000417684	ERG	chr21	39947586	-	PLEKHH1	chr14	68022542	+
5CDS-intron	ENST00000442448	ENST00000559832	ERG	chr21	39947586	-	PLEKHH1	chr14	68022542	+
5UTR-3CDS	ENST00000398897	ENST00000329153	ERG	chr21	39947586	-	PLEKHH1	chr14	68022542	+
5UTR-3CDS	ENST00000485493	ENST00000329153	ERG	chr21	39947586	-	PLEKHH1	chr14	68022542	+
5UTR-intron	ENST00000398897	ENST00000417684	ERG	chr21	39947586	-	PLEKHH1	chr14	68022542	+
5UTR-intron	ENST00000398897	ENST00000559832	ERG	chr21	39947586	-	PLEKHH1	chr14	68022542	+
5UTR-intron	ENST00000485493	ENST00000417684	ERG	chr21	39947586	-	PLEKHH1	chr14	68022542	+
5UTR-intron	ENST00000485493	ENST00000559832	ERG	chr21	39947586	-	PLEKHH1	chr14	68022542	+
Frame-shift	ENST00000398910	ENST00000329153	ERG	chr21	39947586	-	PLEKHH1	chr14	68022542	+
Frame-shift	ENST00000417133	ENST00000329153	ERG	chr21	39947586	-	PLEKHH1	chr14	68022542	+
Frame-shift	ENST00000442448	ENST00000329153	ERG	chr21	39947586	-	PLEKHH1	chr14	68022542	+
In-frame	ENST00000398911	ENST00000329153	ERG	chr21	39947586	-	PLEKHH1	chr14	68022542	+
In-frame	ENST00000398919	ENST00000329153	ERG	chr21	39947586	-	PLEKHH1	chr14	68022542	+
intron-3CDS	ENST00000288319	ENST00000329153	ERG	chr21	39947586	-	PLEKHH1	chr14	68022542	+
intron-3CDS	ENST00000398905	ENST00000329153	ERG	chr21	39947586	-	PLEKHH1	chr14	68022542	+
intron-3CDS	ENST00000398907	ENST00000329153	ERG	chr21	39947586	-	PLEKHH1	chr14	68022542	+
intron-3CDS	ENST00000429727	ENST00000329153	ERG	chr21	39947586	-	PLEKHH1	chr14	68022542	+
intron-3CDS	ENST00000453032	ENST00000329153	ERG	chr21	39947586	-	PLEKHH1	chr14	68022542	+
intron-intron	ENST00000288319	ENST00000417684	ERG	chr21	39947586	-	PLEKHH1	chr14	68022542	+
intron-intron	ENST00000288319	ENST00000559832	ERG	chr21	39947586	-	PLEKHH1	chr14	68022542	+
intron-intron	ENST00000398905	ENST00000417684	ERG	chr21	39947586	-	PLEKHH1	chr14	68022542	+
intron-intron	ENST00000398905	ENST00000559832	ERG	chr21	39947586	-	PLEKHH1	chr14	68022542	+
intron-intron	ENST00000398907	ENST00000417684	ERG	chr21	39947586	-	PLEKHH1	chr14	68022542	+
intron-intron	ENST00000398907	ENST00000559832	ERG	chr21	39947586	-	PLEKHH1	chr14	68022542	+
intron-intron	ENST00000429727	ENST00000417684	ERG	chr21	39947586	-	PLEKHH1	chr14	68022542	+
intron-intron	ENST00000429727	ENST00000559832	ERG	chr21	39947586	-	PLEKHH1	chr14	68022542	+
intron-intron	ENST00000453032	ENST00000417684	ERG	chr21	39947586	-	PLEKHH1	chr14	68022542	+
intron-intron	ENST00000453032	ENST00000559832	ERG	chr21	39947586	-	PLEKHH1	chr14	68022542	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000398911

ERG

chr21

39947586

ENST00000329153

PLEKHH1

chr14

68022542

6534

188

140

4156

1338

ENST00000398919

ERG

chr21

39947586

ENST00000329153

PLEKHH1

chr14

68022542

6680

334

286

4302

1338

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000398911	ENST00000329153	ERG	chr21	39947586	-	PLEKHH1	chr14	68022542	+	0.001442608	0.9985574
ENST00000398919	ENST00000329153	ERG	chr21	39947586	-	PLEKHH1	chr14	68022542	+	0.001581855	0.9984181

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Fusion Genomic Features for ERG-PLEKHH1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
ERG	chr21	39947585	-	PLEKHH1	chr14	68022541	+	1.85E-08	1
ERG	chr21	39947585	-	PLEKHH1	chr14	68022541	+	1.85E-08	1
ERG	chr21	39947585	-	PLEKHH1	chr14	68022541	+	1.85E-08	1
ERG	chr21	39947585	-	PLEKHH1	chr14	68022541	+	1.85E-08	1

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ERG-PLEKHH1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr21:39947586/chr14:68022542)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

PLEKHH1

chr21:39947586

chr14:68022542

ENST00000329153

239_242

1365.0

Compositional bias

Note=Poly-Ser

Tgene

PLEKHH1

chr21:39947586

chr14:68022542

ENST00000329153

578_672

1365.0

Domain

PH 1

Tgene

PLEKHH1

chr21:39947586

chr14:68022542

ENST00000329153

687_796

1365.0

Domain

PH 2

Tgene

PLEKHH1

chr21:39947586

chr14:68022542

ENST00000329153

832_986

1365.0

Domain

MyTH4

Tgene

PLEKHH1

chr21:39947586

chr14:68022542

ENST00000329153

997_1333

1365.0

Domain

FERM

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ERG

chr21:39947586

chr14:68022542

ENST00000288319

311_391

480.0

DNA binding

ETS

Hgene

ERG

chr21:39947586

chr14:68022542

ENST00000398897

311_391

364.0

DNA binding

ETS

Hgene

ERG

chr21:39947586

chr14:68022542

ENST00000398911

311_391

463.0

DNA binding

ETS

Hgene

ERG

chr21:39947586

chr14:68022542

ENST00000398919

311_391

487.0

DNA binding

ETS

Hgene

ERG

chr21:39947586

chr14:68022542

ENST00000417133

311_391

487.0

DNA binding

ETS

Hgene

ERG

chr21:39947586

chr14:68022542

ENST00000442448

311_391

463.0

DNA binding

ETS

Hgene

ERG

chr21:39947586

chr14:68022542

ENST00000453032

311_391

388.0

DNA binding

ETS

Hgene

ERG

chr21:39947586

chr14:68022542

ENST00000288319

113_199

480.0

Domain

PNT

Hgene

ERG

chr21:39947586

chr14:68022542

ENST00000398897

113_199

364.0

Domain

PNT

Hgene

ERG

chr21:39947586

chr14:68022542

ENST00000398911

113_199

463.0

Domain

PNT

Hgene

ERG

chr21:39947586

chr14:68022542

ENST00000398919

113_199

487.0

Domain

PNT

Hgene

ERG

chr21:39947586

chr14:68022542

ENST00000417133

113_199

487.0

Domain

PNT

Hgene

ERG

chr21:39947586

chr14:68022542

ENST00000442448

113_199

463.0

Domain

PNT

Hgene

ERG

chr21:39947586

chr14:68022542

ENST00000453032

113_199

388.0

Domain

PNT

Tgene

PLEKHH1

chr21:39947586

chr14:68022542

ENST00000329153

28_169

1365.0

Coiled coil

Ontology_term=ECO:0000255

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Fusion Gene Sequence for ERG-PLEKHH1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>27373_27373_1_ERG-PLEKHH1_ERG_chr21_39947586_ENST00000398911_PLEKHH1_chr14_68022542_ENST00000329153_length(transcript)=6534nt_BP=188nt
GTTATTCCAGGATCTTTGGAGACCCGAGGAAAGCCGTGTTGACCAAAAGCAAGACAAATGACTCACAGAGAAAAAAGATGGCAGAACCAA
GGGCAACTAAAGCCGTCAGGTTCTGAACAGCTGGTAGATGGGCTGGCTTACTGAAGGACATGATTCAGACTGTCCCGGACCCAGCAGCTC
ATATCAAGATGCAGGAGCTGGAGCAGAGGCTGCTGGAGGCAGAGCAGAGAGCAGAGAACGCTGAGACCCAGGTGGGTGTCATGGAAGAGA
AGGTAAAACTATCCAATCTGAAGAATGTGGACTCTGAGGGGAGCCTGCACCGGAAATACCAAGAATTGCTGAAAGCCATAAAGGGCAAAG
ATGAGCTCATCAGCCAGCTAGAGGCTCAGCTGGAGAAGCAGAAGCAGATGAGGGCAGAGGAAGCAAAAACTGTTCAAGAAAAAGCTGCAA
AGATCAAGGAATGGGTGACACTCAAGTTGGCAAAGCTTGAGATGGAGAATCAGCATCTGAAAAGCCATAATCAGCGCCTGGTGGAGCAGG
TGGGATCCCTTCAAGATGCGCTAGAAGCTATTCAGATAGCTCCTTCACGGAAGCTGCTGGTGCCCCCCTACGGAGCTGCAGAGCAGGATT
CTGTCCCTTCAGAGCCGGGAATCCAGCCTATGGGCCAGGACAGTGGCTCCCAGGCCCAGGGTCTGAAGGCAGCTGTGCTTGCACCTTCCC
CAGGTGCCCTGCAGAGCAAGGACTCTGTTTCTGAAGCAGCAAGCCCCTTGGAGGATTCTAGTTCCAGCACGGTCCATTCTGGGGAAACAG
TAGAGGCCAAGCCCCTTCAACCTCATCTGGGAAGAGAGAGCCCTCCCCACCAGCCATGCATGAAGCTTCTTACCTTCAGATGTAGTTCAG
CTTCCTGGGGTGAGGGTCTGGTTACTGCTCAGAGAGGGATGCTCCCTGGGACAAAGACCTCTGCCAGGGAAGGTGGTCCTGGCAGCAGTC
TGACCCTACCAAAGGTGCGGGCTCCTGGCACCCCGCGGGACAGCATCCAGTTGGCCAAAAGGCACCACAGCCAGCCCCAGGTGGGCCATG
GGCACTTTGGCCGTGTGGTGAACATTGAGACTGAGGCCTTCTCAGCCCTCCACCCCTCTGGCCTTCCTGAGCTGGAGTCCCGAGCTAGGT
CCCGGGAGGAACCAGAGAAGATGGAGATGGAGGAGCCACCCCCAGCAGGGAAGAATGAGGAAAGAGAGAGCCCAAAGGCCCTTGGAGCTG
AGCTGGAGGAAGTGGAGCTGGGTAACAAGCCACCTACACCCCCGCTGCACCAGTTTTCATCCTGGGAGAGCCGGATCTATGCTGTGGCCA
CATCGGGCATGCGGCTCTCAGATATGTCTCCCAGAAGTAATACTGCATGCTGCGCTTCAAGCCCTCCTGCCCTTGTTTCCCCTGGGTCTT
TCTCTGGCCTGGTCTACAAGAATGTCACTGTGCCTGTCTACACAGCACTGAAGGGGAGAGCTACACAGATCAGCAACATGCCCTTTATGG
ACGAGTCCTCTGGGTCTGACGATGACTGCAGCTCTCAGGCGAGTTTCCGAATCTCGGTCCCCTCCTCTGAGTCCAGGAAGACCAGCGGAC
TAGGCAGCCCCCGGGCCATCAAGAGAGGCGTCTCCATGTCCTCACTGAGCTCCGAGGGTGACTACGCCATCCCCCCGGACGCCTGCTCAC
TGGACAGTGACTACTCAGAGCCTGAGCACAAACTGCAGCGCACCTCATCCTACTCCACCGACGGGCTGGGCCTGGGCGGGGAGTCACTGG
AGAAGTCGGGCTACCTGCTGAAAATGGGGAGCCAGGTGAAGACGTGGAAGAGGCGCTGGTTTGTCCTGAGACAGGGACAGATTATGTACT
ACAAGTCCCCGAGTGATGTCATCCGGAAACCTCAAGGCCAAGTGGATCTGAACTCCCGCTGCCAAATTGTTCGAGGGGAGGGTTCACAGA
CGTTTCAGCTCATCTCTGAGAAGAAAACCTACTACCTGACGGCCGATTCACCCAGCCTGCTGGAGGAGTGGATCCGAGTACTCCAGAGCC
TGCTGAAGGTGCAGGCCACCGGGCCTCCAGCTCTGCTTCGGGGTGGCACCAAGCCCACCGTGAAGGGCTGGCTGACCAAGGTAAAGCATG
GCCACTCCAAGGTGGTCTGGTGCGCTCTTGTTGGGAAAATCTTCTACTACTATCGGAGCCATGAGGACAAGCGACCCCTGGGCTGCCTGC
CTGTGCGGGATGCGCACATAGAGGAAGTAGATCGATCCTGTGACTCAGACGAGGACTATGAGGCTGGAGGAACCAGACGGTTGCTTTCCT
CCCACTGCACCCTGGTGATCCACCCCACAGAGCACAGCCCCACCTACCTCCTCATTGGCACCAAGCATGAAAAGGATACGTGGCTCTACC
ACCTCACAGTGGCTGCAGGTGGCAGCAGTGCCAAGGTGGGCACTGCCTATGAGCAGCTCATTGGAAAACTGATGGATGGTGAAGGAGATC
CAGATTCGCCGCTCTGGAGGCACCCCATGCTGTGCTACAGCAAAGACGGCCTATACGCCTCCCTCACCACCCTGCCCTCTGAGGCCTTGC
AGACGGAGGCCCTCAAGCTCTTCAAGTCCTGCCAGCTCTTCATCAACGTGCCGGTGGAAGCTGCCTCGGTGGACTACCATGTGTCCCTGG
CCCAGACCGCACTGCAGGTCTGCCTGGTTCACCCCGAGCTGCAGAGTGAGATCTACTGCCAACTCATGAAGCAGACCAGCTGCCGCCCAC
CTCAGAAGTACTCCCTCATGCAGTGCTGGCAGCTCCTCGCTCTGTGTGCTCCACTTTTCCTGCCTCAGCATCACTTCCTCTGGTATGTCA
AGCAGCAGCTCCAACGCCATGCAGATCCCAGAAGTGAAACTGGCCAGTATGCCACCTACTGCCAGCGGGCAGTGGAGCGGACCCTGCGGA
CCGGGGAGCGGGAAGCCAGGCCATCGCGCATGGAAGTGGTGTCCATCCTGCTGCGTAACCCCTTCCACCACTCCTTGCCCTTCAGCATCC
CCGTGCACTTTACCAACGGGACTTACCATGTGGTTGGTTTTGACGGCTCTTCCACGGTTGATGAGTTCCTCCAGCGGCTGAACCAGGAGA
TAGGCATGAGAAAGCCATCCCACTCTGGCTTTGCCCTCTTCACGGACGATCCCTCGGGCAGGGACCTGGAGCACTGCCTGCAGGGAAGTG
TCAAGATCTGTGATGCCATCTCCAAGTGGGAACAAGCCATGAAGGAGCTGCACCCCGGAAAGTCTGAGGGTGGGACACGCGTCGTGAAGC
TGATGTACAAGAACAGGCTGTACTTTCGCAGTCAAGTCAAAGGGGAGACGGACCGAGAACGGCTGCTCCTTGCCTCTCAAACCAGTAGAG
AGATAGTGGCAGGGAGGTTTCCTATCAACAAGGAATTGGCTCTTGAGATGGCTGCCCTGATGGCCCAGGTAGAATATGGGGACTTGGAGA
AGCCTGCCCTGCCAGGCCCTGGAGGCACATCCCCTGCCAAGGCTCAGCATCTTCTCCAGCAGGTCCTAGACAGGTTCCACCCCAGGCGCT
ATAGACATGGGGCCCCCGCTGAACAGCTGAGGCACCTGGCAGATATGTTGACCACAAAATGGGCAACATTGCAAGGATGCTCCCCTCCTG
AGTGCATCCGCATCTACCTGACCGTGGCCAGGAAATGGCCTTTCTTTGGTGCTAAACTTTTTGCTGCTCAGCCTGCCCAGCTGTCTTCCA
AGGAGAACGCTCTGGTGTGGATTGCTGTGAATGAGGATGGCGTCAGCATCCTGGACCACAACACTATGCAAGTGCACATCACTTACCCCT
ACTCTTCAGTGACAACGTTTGGTGGCTGCAGGGATGACTTCATGCTTGTGATTAGATCTATCCCAGACAAGAGCTCTGGAAAAAGCCACA
TTGAGAAGTTGATCTTCCGGATGGCTGCTCCCAAGATTGCAGAAGCTACCTTCATCATGGCCAGCTATATGAACCATTGCACTACAACTG
TGAACCCCCCCACCAACCCACCCGGAGCCTGCCAGCTGTGGGAACTGGATGGACGACAGTTCTTTTCTTCTGTTTCCTGTGCTACCAAGG
GGCCAACGTTGCTGTGAATATTTCTCCTACCCGATTCCCCAACACCACTAGTGCCTCTGGATTTAGAGATATATATCCTAGGGTATGATA
CTACTGTGACGGGTCTAACAGCCCCCGGCTACTCTTGTTCTGTGAAATGTGTATTTTAGTCTCTGTGAAGCCTTTACTCTCTAGGTGCCT
TATAATGTTTCAGGGCTCAACTTTTTAAAATCCAGACCCAGTGTTAAAACCATTTATTCCTTTTTTCATAAGAATAATGACTCCAGATGC
TACCTGATTCTAGACATAGACAGGGATGATCCACTGTTACTGAGGGCATCAGTGCTATAAGTTAAGGCTTTCTGCACTGGTACTCTCAAG
GAAGCTAATTTTCTTTCTGGGGGGGGCGGGGGACACAGTGTCACTATGTCACCCAGTCCACAGGGTTCAAGCAATTCTCCTGCCTCAGCC
TTCGGAGTGGCTGGGATTACAGGTGTGCGCCACCATGCCCGGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTGGCCAG
GCTGGTCTCGAACTCCTGACCTCAGGTGATCTGCCCACTTTGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCATCGCCCAGCCCAG
AAGCTAATTTTTTAATATTGTATATGGTCTTATTTATACTTGAAGTTTTGTGAACGTCGCTAAACAGGATAGGACTAAAATTTCCAATTC
TCCTACACTCTGTCAGAAGCCTAGAACTCACTAAACTGGGCTGCCTTTCCCAAATGGGAAAGGTGCTGACAGAGTTGGAGAAAAAAGAAT
AGACTCATTTTTCCCCATTATTGGTATGTAGGCATTGGTACAGCCCCTTCTGGGGCAGTCTTTGCAGGATAACATGCTATACCTGCTAAG
ATTCAAGCTGTTTTCCTCACACTGGACTTTAGGCCAAACCCAGTACCACGCAATGTGCAAGCAAGGGCAGGAGGTAGGTCCAATCTGACC
CCTCCCTGTCTCATTTTAATGACTGGACAGCGCTCGGTGAAGGCTGTGTTCACTGTAGTGGGCCATCATTTGTTTCCTTCTTCTTGTAAA
AGACCAAGCAAATGCACTCTGCTTTTTGCTGCTGTAAGACCACCAAAAATGAGTCAGAAACACAGAAGACTATTTCAGGCATGTGGGCCT
GGATATGCTCCTTGAGACTTCTGGCAAACTTCTGCTGGGAATTAGTTTGAGGGTGAGGGTACATATGTGACATTTGCCCTAGCCTAAGAG
TAGCAGGTAAAAAAAAGTTTCTTTCATCTTTTGCCTTACTGATAATACCATAATCCCCCTCAATTCAGACCTTCTGATTGAGTGCAGAGG
AGACTAGACAGTCTCCTCTAGACAGGTTGTAGACACACCCTCCCCTAACAAAAACAAAACGAAAGAGTTCATACTCTGATTTTCCAACAT
CTAGGAAACTGAGTTTTATTTCCTAGCTCTAAGGCAGCCTTACTATATGTCAGTAAAGTGCTGAAAACTGTATATTTAGCAGTAGCACCC
AAAACCAAGCCTTTAACCCCAACAATGTGTGTATCTTTTGCACAGCAAAAACTGCGAGGCCAGAACTAGTTTATCTGAACACCTCAGCTG
CTGTAAGCTTCTCCTCTCTCACCCCGTAAACTGACAAGCATGATGAAAAAAGAAGCACATCCAAGTTTCTGCCTCTTTTAAATGTACTTG
ACTTTGCAAGGCAAGTAGTTTTACAGCCATTTCTGTTCACACTTTTCACCCCACAACTTGGGGATCTAGCTGAGACATTTCTACCTCGAA
CAAGTCACATGTACCACAGGTTCCTGAATAATTCCTGCAGGGCTGGTGACAGACATAACAGCTCTGGTTTTATAATATCTTGGGTATCTC
TAAGGCCAATAAGGATAACATTATCTACCCAGAGAGTTTAGAAGAAAAGTAGGAGTCCAAAGGAAGAGTAAACAAGAATGGAGCTGTGTT
CACACTGAATTTGGGGTCAATCTATTTCCCCCACCCTCTCTCCTCCCCAACCCTTCAGGAACCCTTTAGTTTATTAATCTTATACAGAAG
AAACTAACTTAGAAACAAAGGATTCAATATTTGCTTATTTATTCTTTGTTAACATGAGAGTCCCATGTCTGAAAACCAAAGTCCAATTTC
TGTCTGGCCTTTTGTCTCATCCTTCTTGGCAAAAGTAGCTTTTGAACTGATATAAAAAAAAATGCTGAGTAACAGAAAAGTATTAATGTG
CTTGACACCATGACTGAAATACTATGATCTTGTTTGTCAATAAAAAGCAGCTATCTGTGAACCAGGTAACTGTGTGTTTTGGAAGATCTG

>27373_27373_1_ERG-PLEKHH1_ERG_chr21_39947586_ENST00000398911_PLEKHH1_chr14_68022542_ENST00000329153_length(amino acids)=1338AA_BP=16
MKDMIQTVPDPAAHIKMQELEQRLLEAEQRAENAETQVGVMEEKVKLSNLKNVDSEGSLHRKYQELLKAIKGKDELISQLEAQLEKQKQM
RAEEAKTVQEKAAKIKEWVTLKLAKLEMENQHLKSHNQRLVEQVGSLQDALEAIQIAPSRKLLVPPYGAAEQDSVPSEPGIQPMGQDSGS
QAQGLKAAVLAPSPGALQSKDSVSEAASPLEDSSSSTVHSGETVEAKPLQPHLGRESPPHQPCMKLLTFRCSSASWGEGLVTAQRGMLPG
TKTSAREGGPGSSLTLPKVRAPGTPRDSIQLAKRHHSQPQVGHGHFGRVVNIETEAFSALHPSGLPELESRARSREEPEKMEMEEPPPAG
KNEERESPKALGAELEEVELGNKPPTPPLHQFSSWESRIYAVATSGMRLSDMSPRSNTACCASSPPALVSPGSFSGLVYKNVTVPVYTAL
KGRATQISNMPFMDESSGSDDDCSSQASFRISVPSSESRKTSGLGSPRAIKRGVSMSSLSSEGDYAIPPDACSLDSDYSEPEHKLQRTSS
YSTDGLGLGGESLEKSGYLLKMGSQVKTWKRRWFVLRQGQIMYYKSPSDVIRKPQGQVDLNSRCQIVRGEGSQTFQLISEKKTYYLTADS
PSLLEEWIRVLQSLLKVQATGPPALLRGGTKPTVKGWLTKVKHGHSKVVWCALVGKIFYYYRSHEDKRPLGCLPVRDAHIEEVDRSCDSD
EDYEAGGTRRLLSSHCTLVIHPTEHSPTYLLIGTKHEKDTWLYHLTVAAGGSSAKVGTAYEQLIGKLMDGEGDPDSPLWRHPMLCYSKDG
LYASLTTLPSEALQTEALKLFKSCQLFINVPVEAASVDYHVSLAQTALQVCLVHPELQSEIYCQLMKQTSCRPPQKYSLMQCWQLLALCA
PLFLPQHHFLWYVKQQLQRHADPRSETGQYATYCQRAVERTLRTGEREARPSRMEVVSILLRNPFHHSLPFSIPVHFTNGTYHVVGFDGS
STVDEFLQRLNQEIGMRKPSHSGFALFTDDPSGRDLEHCLQGSVKICDAISKWEQAMKELHPGKSEGGTRVVKLMYKNRLYFRSQVKGET
DRERLLLASQTSREIVAGRFPINKELALEMAALMAQVEYGDLEKPALPGPGGTSPAKAQHLLQQVLDRFHPRRYRHGAPAEQLRHLADML
TTKWATLQGCSPPECIRIYLTVARKWPFFGAKLFAAQPAQLSSKENALVWIAVNEDGVSILDHNTMQVHITYPYSSVTTFGGCRDDFMLV

--------------------------------------------------------------
>27373_27373_2_ERG-PLEKHH1_ERG_chr21_39947586_ENST00000398919_PLEKHH1_chr14_68022542_ENST00000329153_length(transcript)=6680nt_BP=334nt
GCTGAGCCCGTCGGCGCCGAGGGAGTTAGTGCGACCCGGCTCGGCGCGCACGGCCAAGGCACGCGCGCTGGCACACGCGGGCGCGGACAC
GCGCGGACACACACGTGCGGGACACGCCCTCCCCCGACGGCGGCGCTAACCTCTCGGTTATTCCAGGATCTTTGGAGACCCGAGGAAAGC
CGTGTTGACCAAAAGCAAGACAAATGACTCACAGAGAAAAAAGATGGCAGAACCAAGGGCAACTAAAGCCGTCAGGTTCTGAACAGCTGG
TAGATGGGCTGGCTTACTGAAGGACATGATTCAGACTGTCCCGGACCCAGCAGCTCATATCAAGATGCAGGAGCTGGAGCAGAGGCTGCT
GGAGGCAGAGCAGAGAGCAGAGAACGCTGAGACCCAGGTGGGTGTCATGGAAGAGAAGGTAAAACTATCCAATCTGAAGAATGTGGACTC
TGAGGGGAGCCTGCACCGGAAATACCAAGAATTGCTGAAAGCCATAAAGGGCAAAGATGAGCTCATCAGCCAGCTAGAGGCTCAGCTGGA
GAAGCAGAAGCAGATGAGGGCAGAGGAAGCAAAAACTGTTCAAGAAAAAGCTGCAAAGATCAAGGAATGGGTGACACTCAAGTTGGCAAA
GCTTGAGATGGAGAATCAGCATCTGAAAAGCCATAATCAGCGCCTGGTGGAGCAGGTGGGATCCCTTCAAGATGCGCTAGAAGCTATTCA
GATAGCTCCTTCACGGAAGCTGCTGGTGCCCCCCTACGGAGCTGCAGAGCAGGATTCTGTCCCTTCAGAGCCGGGAATCCAGCCTATGGG
CCAGGACAGTGGCTCCCAGGCCCAGGGTCTGAAGGCAGCTGTGCTTGCACCTTCCCCAGGTGCCCTGCAGAGCAAGGACTCTGTTTCTGA
AGCAGCAAGCCCCTTGGAGGATTCTAGTTCCAGCACGGTCCATTCTGGGGAAACAGTAGAGGCCAAGCCCCTTCAACCTCATCTGGGAAG
AGAGAGCCCTCCCCACCAGCCATGCATGAAGCTTCTTACCTTCAGATGTAGTTCAGCTTCCTGGGGTGAGGGTCTGGTTACTGCTCAGAG
AGGGATGCTCCCTGGGACAAAGACCTCTGCCAGGGAAGGTGGTCCTGGCAGCAGTCTGACCCTACCAAAGGTGCGGGCTCCTGGCACCCC
GCGGGACAGCATCCAGTTGGCCAAAAGGCACCACAGCCAGCCCCAGGTGGGCCATGGGCACTTTGGCCGTGTGGTGAACATTGAGACTGA
GGCCTTCTCAGCCCTCCACCCCTCTGGCCTTCCTGAGCTGGAGTCCCGAGCTAGGTCCCGGGAGGAACCAGAGAAGATGGAGATGGAGGA
GCCACCCCCAGCAGGGAAGAATGAGGAAAGAGAGAGCCCAAAGGCCCTTGGAGCTGAGCTGGAGGAAGTGGAGCTGGGTAACAAGCCACC
TACACCCCCGCTGCACCAGTTTTCATCCTGGGAGAGCCGGATCTATGCTGTGGCCACATCGGGCATGCGGCTCTCAGATATGTCTCCCAG
AAGTAATACTGCATGCTGCGCTTCAAGCCCTCCTGCCCTTGTTTCCCCTGGGTCTTTCTCTGGCCTGGTCTACAAGAATGTCACTGTGCC
TGTCTACACAGCACTGAAGGGGAGAGCTACACAGATCAGCAACATGCCCTTTATGGACGAGTCCTCTGGGTCTGACGATGACTGCAGCTC
TCAGGCGAGTTTCCGAATCTCGGTCCCCTCCTCTGAGTCCAGGAAGACCAGCGGACTAGGCAGCCCCCGGGCCATCAAGAGAGGCGTCTC
CATGTCCTCACTGAGCTCCGAGGGTGACTACGCCATCCCCCCGGACGCCTGCTCACTGGACAGTGACTACTCAGAGCCTGAGCACAAACT
GCAGCGCACCTCATCCTACTCCACCGACGGGCTGGGCCTGGGCGGGGAGTCACTGGAGAAGTCGGGCTACCTGCTGAAAATGGGGAGCCA
GGTGAAGACGTGGAAGAGGCGCTGGTTTGTCCTGAGACAGGGACAGATTATGTACTACAAGTCCCCGAGTGATGTCATCCGGAAACCTCA
AGGCCAAGTGGATCTGAACTCCCGCTGCCAAATTGTTCGAGGGGAGGGTTCACAGACGTTTCAGCTCATCTCTGAGAAGAAAACCTACTA
CCTGACGGCCGATTCACCCAGCCTGCTGGAGGAGTGGATCCGAGTACTCCAGAGCCTGCTGAAGGTGCAGGCCACCGGGCCTCCAGCTCT
GCTTCGGGGTGGCACCAAGCCCACCGTGAAGGGCTGGCTGACCAAGGTAAAGCATGGCCACTCCAAGGTGGTCTGGTGCGCTCTTGTTGG
GAAAATCTTCTACTACTATCGGAGCCATGAGGACAAGCGACCCCTGGGCTGCCTGCCTGTGCGGGATGCGCACATAGAGGAAGTAGATCG
ATCCTGTGACTCAGACGAGGACTATGAGGCTGGAGGAACCAGACGGTTGCTTTCCTCCCACTGCACCCTGGTGATCCACCCCACAGAGCA
CAGCCCCACCTACCTCCTCATTGGCACCAAGCATGAAAAGGATACGTGGCTCTACCACCTCACAGTGGCTGCAGGTGGCAGCAGTGCCAA
GGTGGGCACTGCCTATGAGCAGCTCATTGGAAAACTGATGGATGGTGAAGGAGATCCAGATTCGCCGCTCTGGAGGCACCCCATGCTGTG
CTACAGCAAAGACGGCCTATACGCCTCCCTCACCACCCTGCCCTCTGAGGCCTTGCAGACGGAGGCCCTCAAGCTCTTCAAGTCCTGCCA
GCTCTTCATCAACGTGCCGGTGGAAGCTGCCTCGGTGGACTACCATGTGTCCCTGGCCCAGACCGCACTGCAGGTCTGCCTGGTTCACCC
CGAGCTGCAGAGTGAGATCTACTGCCAACTCATGAAGCAGACCAGCTGCCGCCCACCTCAGAAGTACTCCCTCATGCAGTGCTGGCAGCT
CCTCGCTCTGTGTGCTCCACTTTTCCTGCCTCAGCATCACTTCCTCTGGTATGTCAAGCAGCAGCTCCAACGCCATGCAGATCCCAGAAG
TGAAACTGGCCAGTATGCCACCTACTGCCAGCGGGCAGTGGAGCGGACCCTGCGGACCGGGGAGCGGGAAGCCAGGCCATCGCGCATGGA
AGTGGTGTCCATCCTGCTGCGTAACCCCTTCCACCACTCCTTGCCCTTCAGCATCCCCGTGCACTTTACCAACGGGACTTACCATGTGGT
TGGTTTTGACGGCTCTTCCACGGTTGATGAGTTCCTCCAGCGGCTGAACCAGGAGATAGGCATGAGAAAGCCATCCCACTCTGGCTTTGC
CCTCTTCACGGACGATCCCTCGGGCAGGGACCTGGAGCACTGCCTGCAGGGAAGTGTCAAGATCTGTGATGCCATCTCCAAGTGGGAACA
AGCCATGAAGGAGCTGCACCCCGGAAAGTCTGAGGGTGGGACACGCGTCGTGAAGCTGATGTACAAGAACAGGCTGTACTTTCGCAGTCA
AGTCAAAGGGGAGACGGACCGAGAACGGCTGCTCCTTGCCTCTCAAACCAGTAGAGAGATAGTGGCAGGGAGGTTTCCTATCAACAAGGA
ATTGGCTCTTGAGATGGCTGCCCTGATGGCCCAGGTAGAATATGGGGACTTGGAGAAGCCTGCCCTGCCAGGCCCTGGAGGCACATCCCC
TGCCAAGGCTCAGCATCTTCTCCAGCAGGTCCTAGACAGGTTCCACCCCAGGCGCTATAGACATGGGGCCCCCGCTGAACAGCTGAGGCA
CCTGGCAGATATGTTGACCACAAAATGGGCAACATTGCAAGGATGCTCCCCTCCTGAGTGCATCCGCATCTACCTGACCGTGGCCAGGAA
ATGGCCTTTCTTTGGTGCTAAACTTTTTGCTGCTCAGCCTGCCCAGCTGTCTTCCAAGGAGAACGCTCTGGTGTGGATTGCTGTGAATGA
GGATGGCGTCAGCATCCTGGACCACAACACTATGCAAGTGCACATCACTTACCCCTACTCTTCAGTGACAACGTTTGGTGGCTGCAGGGA
TGACTTCATGCTTGTGATTAGATCTATCCCAGACAAGAGCTCTGGAAAAAGCCACATTGAGAAGTTGATCTTCCGGATGGCTGCTCCCAA
GATTGCAGAAGCTACCTTCATCATGGCCAGCTATATGAACCATTGCACTACAACTGTGAACCCCCCCACCAACCCACCCGGAGCCTGCCA
GCTGTGGGAACTGGATGGACGACAGTTCTTTTCTTCTGTTTCCTGTGCTACCAAGGGGCCAACGTTGCTGTGAATATTTCTCCTACCCGA
TTCCCCAACACCACTAGTGCCTCTGGATTTAGAGATATATATCCTAGGGTATGATACTACTGTGACGGGTCTAACAGCCCCCGGCTACTC
TTGTTCTGTGAAATGTGTATTTTAGTCTCTGTGAAGCCTTTACTCTCTAGGTGCCTTATAATGTTTCAGGGCTCAACTTTTTAAAATCCA
GACCCAGTGTTAAAACCATTTATTCCTTTTTTCATAAGAATAATGACTCCAGATGCTACCTGATTCTAGACATAGACAGGGATGATCCAC
TGTTACTGAGGGCATCAGTGCTATAAGTTAAGGCTTTCTGCACTGGTACTCTCAAGGAAGCTAATTTTCTTTCTGGGGGGGGCGGGGGAC
ACAGTGTCACTATGTCACCCAGTCCACAGGGTTCAAGCAATTCTCCTGCCTCAGCCTTCGGAGTGGCTGGGATTACAGGTGTGCGCCACC
ATGCCCGGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCTGC
CCACTTTGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCATCGCCCAGCCCAGAAGCTAATTTTTTAATATTGTATATGGTCTTATT
TATACTTGAAGTTTTGTGAACGTCGCTAAACAGGATAGGACTAAAATTTCCAATTCTCCTACACTCTGTCAGAAGCCTAGAACTCACTAA
ACTGGGCTGCCTTTCCCAAATGGGAAAGGTGCTGACAGAGTTGGAGAAAAAAGAATAGACTCATTTTTCCCCATTATTGGTATGTAGGCA
TTGGTACAGCCCCTTCTGGGGCAGTCTTTGCAGGATAACATGCTATACCTGCTAAGATTCAAGCTGTTTTCCTCACACTGGACTTTAGGC
CAAACCCAGTACCACGCAATGTGCAAGCAAGGGCAGGAGGTAGGTCCAATCTGACCCCTCCCTGTCTCATTTTAATGACTGGACAGCGCT
CGGTGAAGGCTGTGTTCACTGTAGTGGGCCATCATTTGTTTCCTTCTTCTTGTAAAAGACCAAGCAAATGCACTCTGCTTTTTGCTGCTG
TAAGACCACCAAAAATGAGTCAGAAACACAGAAGACTATTTCAGGCATGTGGGCCTGGATATGCTCCTTGAGACTTCTGGCAAACTTCTG
CTGGGAATTAGTTTGAGGGTGAGGGTACATATGTGACATTTGCCCTAGCCTAAGAGTAGCAGGTAAAAAAAAGTTTCTTTCATCTTTTGC
CTTACTGATAATACCATAATCCCCCTCAATTCAGACCTTCTGATTGAGTGCAGAGGAGACTAGACAGTCTCCTCTAGACAGGTTGTAGAC
ACACCCTCCCCTAACAAAAACAAAACGAAAGAGTTCATACTCTGATTTTCCAACATCTAGGAAACTGAGTTTTATTTCCTAGCTCTAAGG
CAGCCTTACTATATGTCAGTAAAGTGCTGAAAACTGTATATTTAGCAGTAGCACCCAAAACCAAGCCTTTAACCCCAACAATGTGTGTAT
CTTTTGCACAGCAAAAACTGCGAGGCCAGAACTAGTTTATCTGAACACCTCAGCTGCTGTAAGCTTCTCCTCTCTCACCCCGTAAACTGA
CAAGCATGATGAAAAAAGAAGCACATCCAAGTTTCTGCCTCTTTTAAATGTACTTGACTTTGCAAGGCAAGTAGTTTTACAGCCATTTCT
GTTCACACTTTTCACCCCACAACTTGGGGATCTAGCTGAGACATTTCTACCTCGAACAAGTCACATGTACCACAGGTTCCTGAATAATTC
CTGCAGGGCTGGTGACAGACATAACAGCTCTGGTTTTATAATATCTTGGGTATCTCTAAGGCCAATAAGGATAACATTATCTACCCAGAG
AGTTTAGAAGAAAAGTAGGAGTCCAAAGGAAGAGTAAACAAGAATGGAGCTGTGTTCACACTGAATTTGGGGTCAATCTATTTCCCCCAC
CCTCTCTCCTCCCCAACCCTTCAGGAACCCTTTAGTTTATTAATCTTATACAGAAGAAACTAACTTAGAAACAAAGGATTCAATATTTGC
TTATTTATTCTTTGTTAACATGAGAGTCCCATGTCTGAAAACCAAAGTCCAATTTCTGTCTGGCCTTTTGTCTCATCCTTCTTGGCAAAA
GTAGCTTTTGAACTGATATAAAAAAAAATGCTGAGTAACAGAAAAGTATTAATGTGCTTGACACCATGACTGAAATACTATGATCTTGTT
TGTCAATAAAAAGCAGCTATCTGTGAACCAGGTAACTGTGTGTTTTGGAAGATCTGTTTATTAACAGTAAATAAATAAGCCCTGTACAGA

>27373_27373_2_ERG-PLEKHH1_ERG_chr21_39947586_ENST00000398919_PLEKHH1_chr14_68022542_ENST00000329153_length(amino acids)=1338AA_BP=16
MKDMIQTVPDPAAHIKMQELEQRLLEAEQRAENAETQVGVMEEKVKLSNLKNVDSEGSLHRKYQELLKAIKGKDELISQLEAQLEKQKQM
RAEEAKTVQEKAAKIKEWVTLKLAKLEMENQHLKSHNQRLVEQVGSLQDALEAIQIAPSRKLLVPPYGAAEQDSVPSEPGIQPMGQDSGS
QAQGLKAAVLAPSPGALQSKDSVSEAASPLEDSSSSTVHSGETVEAKPLQPHLGRESPPHQPCMKLLTFRCSSASWGEGLVTAQRGMLPG
TKTSAREGGPGSSLTLPKVRAPGTPRDSIQLAKRHHSQPQVGHGHFGRVVNIETEAFSALHPSGLPELESRARSREEPEKMEMEEPPPAG
KNEERESPKALGAELEEVELGNKPPTPPLHQFSSWESRIYAVATSGMRLSDMSPRSNTACCASSPPALVSPGSFSGLVYKNVTVPVYTAL
KGRATQISNMPFMDESSGSDDDCSSQASFRISVPSSESRKTSGLGSPRAIKRGVSMSSLSSEGDYAIPPDACSLDSDYSEPEHKLQRTSS
YSTDGLGLGGESLEKSGYLLKMGSQVKTWKRRWFVLRQGQIMYYKSPSDVIRKPQGQVDLNSRCQIVRGEGSQTFQLISEKKTYYLTADS
PSLLEEWIRVLQSLLKVQATGPPALLRGGTKPTVKGWLTKVKHGHSKVVWCALVGKIFYYYRSHEDKRPLGCLPVRDAHIEEVDRSCDSD
EDYEAGGTRRLLSSHCTLVIHPTEHSPTYLLIGTKHEKDTWLYHLTVAAGGSSAKVGTAYEQLIGKLMDGEGDPDSPLWRHPMLCYSKDG
LYASLTTLPSEALQTEALKLFKSCQLFINVPVEAASVDYHVSLAQTALQVCLVHPELQSEIYCQLMKQTSCRPPQKYSLMQCWQLLALCA
PLFLPQHHFLWYVKQQLQRHADPRSETGQYATYCQRAVERTLRTGEREARPSRMEVVSILLRNPFHHSLPFSIPVHFTNGTYHVVGFDGS
STVDEFLQRLNQEIGMRKPSHSGFALFTDDPSGRDLEHCLQGSVKICDAISKWEQAMKELHPGKSEGGTRVVKLMYKNRLYFRSQVKGET
DRERLLLASQTSREIVAGRFPINKELALEMAALMAQVEYGDLEKPALPGPGGTSPAKAQHLLQQVLDRFHPRRYRHGAPAEQLRHLADML
TTKWATLQGCSPPECIRIYLTVARKWPFFGAKLFAAQPAQLSSKENALVWIAVNEDGVSILDHNTMQVHITYPYSSVTTFGGCRDDFMLV

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for ERG-PLEKHH1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for ERG-PLEKHH1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for ERG-PLEKHH1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source