Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ERICH1-DPYD (FusionGDB2 ID:27403)

Fusion Gene Summary for ERICH1-DPYD

Fusion gene summary

Fusion gene information	Fusion gene name: ERICH1-DPYD
	Fusion gene ID: 27403
		Hgene	Tgene
	Gene symbol	ERICH1	DPYD
	Gene ID	157697	1806
	Gene name	glutamate rich 1	dihydropyrimidine dehydrogenase
	Synonyms	HSPC319	DHP\|DHPDHASE\|DPD
	Cytomap	8p23.3	1p21.3
	Type of gene	protein-coding	protein-coding
	Description	glutamate-rich protein 1	dihydropyrimidine dehydrogenase [NADP(+)]dihydrothymine dehydrogenasedihydrouracil dehydrogenase
	Modification date	20200313	20200313
	UniProtAcc	Q86X53	Q12882
	Ensembl transtripts involved in fusion gene	ENST00000262109, ENST00000522706, ENST00000518277,	ENST00000306031, ENST00000423006, ENST00000474241, ENST00000370192,
Fusion gene scores	* DoF score	8 X 6 X 6=288	12 X 12 X 7=1008
	# samples	8	13
	** MAII score	log2(8/288*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(13/1008*10)=-2.95491211047146 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ERICH1 [Title/Abstract] AND DPYD [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ERICH1(618598)-DPYD(97700550), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	DPYD	GO:0006210	thymine catabolic process	10410956
Tgene	DPYD	GO:0006212	uracil catabolic process	1512248\|18075467
Tgene	DPYD	GO:0006214	thymidine catabolic process	1512248

Fusion gene breakpoints across ERICH1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across DPYD (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	Non-Cancer	TCGA-BH-A0DL-11A	ERICH1	chr8	618598	-	DPYD	chr1	97700550	-

Top

Fusion Gene ORF analysis for ERICH1-DPYD

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000262109	ENST00000306031	ERICH1	chr8	618598	-	DPYD	chr1	97700550	-
5CDS-intron	ENST00000262109	ENST00000423006	ERICH1	chr8	618598	-	DPYD	chr1	97700550	-
5CDS-intron	ENST00000262109	ENST00000474241	ERICH1	chr8	618598	-	DPYD	chr1	97700550	-
5CDS-intron	ENST00000522706	ENST00000306031	ERICH1	chr8	618598	-	DPYD	chr1	97700550	-
5CDS-intron	ENST00000522706	ENST00000423006	ERICH1	chr8	618598	-	DPYD	chr1	97700550	-
5CDS-intron	ENST00000522706	ENST00000474241	ERICH1	chr8	618598	-	DPYD	chr1	97700550	-
In-frame	ENST00000262109	ENST00000370192	ERICH1	chr8	618598	-	DPYD	chr1	97700550	-
In-frame	ENST00000522706	ENST00000370192	ERICH1	chr8	618598	-	DPYD	chr1	97700550	-
intron-3CDS	ENST00000518277	ENST00000370192	ERICH1	chr8	618598	-	DPYD	chr1	97700550	-
intron-intron	ENST00000518277	ENST00000306031	ERICH1	chr8	618598	-	DPYD	chr1	97700550	-
intron-intron	ENST00000518277	ENST00000423006	ERICH1	chr8	618598	-	DPYD	chr1	97700550	-
intron-intron	ENST00000518277	ENST00000474241	ERICH1	chr8	618598	-	DPYD	chr1	97700550	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000522706	ERICH1	chr8	618598	-	ENST00000370192	DPYD	chr1	97700550	-	3024	1012	12	1790	592
ENST00000262109	ERICH1	chr8	618598	-	ENST00000370192	DPYD	chr1	97700550	-	3348	1336	54	2114	686

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000522706	ENST00000370192	ERICH1	chr8	618598	-	DPYD	chr1	97700550	-	0.00094205	0.99905795
ENST00000262109	ENST00000370192	ERICH1	chr8	618598	-	DPYD	chr1	97700550	-	0.000825409	0.99917454

Top

Fusion Genomic Features for ERICH1-DPYD

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for ERICH1-DPYD

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:618598/chr1:97700550)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ERICH1 Q86X53	DPYD Q12882
	FUNCTION: Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ERICH1

chr8:618598

chr1:97700550

ENST00000262109

193_328

419

444.0

Compositional bias

Note=Glu-rich

Tgene

DPYD

chr8:618598

chr1:97700550

ENST00000370192

944_976

766

1026.0

Domain

4Fe-4S ferredoxin-type 2

Tgene

DPYD

chr8:618598

chr1:97700550

ENST00000370192

978_1007

766

1026.0

Domain

4Fe-4S ferredoxin-type 3

Tgene

DPYD

chr8:618598

chr1:97700550

ENST00000370192

793_795

766

1026.0

Nucleotide binding

FMN

Tgene

DPYD

chr8:618598

chr1:97700550

ENST00000370192

816_817

766

1026.0

Nucleotide binding

FMN

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

DPYD

chr8:618598

chr1:97700550

ENST00000370192

69_100

766

1026.0

Domain

4Fe-4S ferredoxin-type 1

Tgene

DPYD

chr8:618598

chr1:97700550

ENST00000370192

194_198

766

1026.0

Nucleotide binding

FAD

Tgene

DPYD

chr8:618598

chr1:97700550

ENST00000370192

218_226

766

1026.0

Nucleotide binding

FAD

Tgene

DPYD

chr8:618598

chr1:97700550

ENST00000370192

340_343

766

1026.0

Nucleotide binding

NADP

Tgene

DPYD

chr8:618598

chr1:97700550

ENST00000370192

364_365

766

1026.0

Nucleotide binding

NADP

Tgene

DPYD

chr8:618598

chr1:97700550

ENST00000370192

437_439

766

1026.0

Nucleotide binding

NADP

Tgene

DPYD

chr8:618598

chr1:97700550

ENST00000370192

480_489

766

1026.0

Nucleotide binding

FAD

Tgene

DPYD

chr8:618598

chr1:97700550

ENST00000370192

481_487

766

1026.0

Nucleotide binding

NADP

Tgene

DPYD

chr8:618598

chr1:97700550

ENST00000370192

574_575

766

1026.0

Nucleotide binding

FMN

Tgene

DPYD

chr8:618598

chr1:97700550

ENST00000370192

668_670

766

1026.0

Region

Substrate binding

Tgene

DPYD

chr8:618598

chr1:97700550

ENST00000370192

736_737

766

1026.0

Region

Substrate binding

Top

Fusion Gene Sequence for ERICH1-DPYD

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>27403_27403_1_ERICH1-DPYD_ERICH1_chr8_618598_ENST00000262109_DPYD_chr1_97700550_ENST00000370192_length(transcript)=3348nt_BP=1336nt
AGGAGGGCGGAACCCGGAAGGCACGGCGCTCAGCTCAGGACCGCGCGCCGTGGTCTGAGGTCCGCGGCAGGGTCCCGCATGGCGGCGCAC
AGGAAGCACGTGTTTGTGGAGAAGGTGCTGCAGAGACTTTTTCCTCCTGTTCCAAGTGGCCAAGGAAAGAGGGAACCCCAGACGCTGGCC
GTCCAAAATCCACCAAAGAAAGTGACCTCTGAGAAAGTGAGCCAGAAACATGCTGAGCCTTTGACAGACACTGGCTCTGAGACCCCGACT
GCCCGACGGCTCTACACTGCCAGCGGGCCTCCTGAGGGCTACGTCCCCTGTTGGCCGGAGCCCAGCAGCTGTGGGAGCCCCGAGAACGCC
TCCAGCGGGGATGACACAGAAGATCAGGATCCTCATGACCAGCCAAAGAGAAGAAGAATTAGGAAGCATAAATCAAAGAAAAAATTTAAA
AATCCCAATAATGTTCTTATAGAACAAGCAGAATTAGAGAAACAGCAGAGTCTGTTACAGGAGAAATCTCAGCGACAGCACACAGATGGC
ACCACAATAAGCAAAAATAAAAAAAGGAAACTGAAAAAGAAACAGCAAATTAAAAGGAAGAAAGCAGCCGGCTTGGCAGCAAAGGCTGCT
GGTGTCAGTTTCATGTACCAGCCCGAGGACAGCAGCAATGAAGGGGAAGGCGTGGGAGAGGCTTGTGAGGAGGATGGTGTGGACACCAGC
GAGGAAGACCCGACACTGGCCGGGGAGGAAGACGTTAAAGATACCAGGGAGGAAGATGGTGCGGACGCTAGCGAGGAAGACCTGACACGG
GCCAGGCAGGAAGAGGGTGCGGACGCCAGTGAGGAAGATCCGACACCGGCCGGGGAGGAAGACGTTAAAGACGCCAGGGAGGAGGACGGT
GTGGACACCATTGAGGAAGACCTGACACGGGCCGGGGAGGAAGACGGTAAAGACACCAGGGAGGAGGACGGTGCGGACGCCAGCGAGGAA
GACCCGACATGGGCTGGGGAGGAAGAGGGTGCAGACTCCGGGGAGGAGGACGGTGCAGACGCCAGCGAGGAAGATGATACAATTACCAAT
GAAAAGGCACACAGTATTCTAAATTTTTTGAAGTCAACACAGGAAATGTATTTTTATGACGGTGTCTCCAGAGATGCAGCTTCAGCTGCC
CTCGCAGATGCCGCTGAGGAGCTGCTGGACCGCCTTGCGTCACACAGCATGCTGCCCTCAGACGTGTCCATCCTGTACCACATGAAAACG
CTGCTGCTCCTGCAAGATACTGAGAGATTGAAGCATGCTCTGGAAATGTTCCCAGAACATTGCACGATGCCTCCTGGGACAGCAATCAGA
CCTATTGCTTTGAGAGCTGTGACCTCCATTGCTCGTGCTCTGCCTGGATTTCCCATTTTGGCTACTGGTGGAATTGACTCTGCTGAAAGT
GGTCTTCAGTTTCTCCATAGTGGTGCTTCCGTCCTCCAGGTATGCAGTGCCATTCAGAATCAGGATTTCACTGTGATCGAAGACTACTGC
ACTGGCCTCAAAGCCCTGCTTTATCTGAAAAGCATTGAAGAACTACAAGACTGGGATGGACAGAGTCCAGCTACTGTGAGTCACCAGAAA
GGGAAACCAGTTCCACGTATAGCTGAACTCATGGACAAGAAACTGCCAAGTTTTGGACCTTATCTGGAACAGCGCAAGAAAATCATAGCA
GAAAACAAGATTAGACTGAAAGAACAAAATGTAGCTTTTTCACCACTTAAGAGAAACTGTTTTATCCCCAAAAGGCCTATTCCTACCATC
AAGGATGTAATAGGAAAAGCACTGCAGTACCTTGGAACATTTGGTGAATTGAGCAACGTAGAGCAAGTTGTGGCTATGATTGATGAAGAA
ATGTGTATCAACTGTGGTAAATGCTACATGACCTGTAATGATTCTGGCTACCAGGCTATACAGTTTGATCCAGAAACCCACCTGCCCACC
ATAACCGACACTTGTACAGGCTGTACTCTGTGTCTCAGTGTTTGCCCTATTGTCGACTGCATCAAAATGGTTTCCAGGACAACACCTTAT
GAACCAAAGAGAGGCGTACCCTTATCTGTGAATCCGGTGTGTTAAGGTGATTTGTGAAACAGTTGCTGTGAACTTTCATGTCACCTACAT
ATGCTGATCTTTTAAAATCATGATCCTTGTGTTCAGCTCTTTCCAAATTAAAACAAATATACATTTTCTAAATAAAAATATGTAATTTCA
AAATACATTTGTAAGTGTAAAAAATGTCTCATGTCAATGACCATTCAATTAGTGGTCATAAAATAGAATAATTCTTTTCTGAGGATAGTA
GTTAAATAACTGTGTGGCAGTTAATTGGATGTTCACTGCCAGTTGTCTTATGTGAAAAATTAACTTTTTTGTGGCAATTAGTGTGACAGT
TTCCAAATTGCCCTATGCTGTGCTCCATATTTGATTTCTAATTGTAAGTGAAATTAAGCATTTTGAAACAAAGTACTCTTTAACATACAA
GAAAATGTATCCAAGGAAACATTTTATCATTAAAAATTACCTTTAATTTTAATGCTGTTTCTAAGAAAATGTAGTTAGCTCCATAAAGTA
CAAATGAAGAAAGTCAAAAAATTATTTGCTATGGCAGGATAAGAAAGCCTAAAATTGAGTTTGTAGAACTTTATTAAGTAAAATCCCCTT
CGCTGAAATTGCTTATTTTTGGTGTTGGATAGAGGATAGGGAGAATATTTACTAACTAAATACCATTCACTACTCATGCGTGAGATGGGT
GTACAAACTCATCCTCTTTTAATGGCATTTCTCTTTAAACTATGTTCCTAACAAAATGAGATGATAGGATAGATCCTGGTTACCACTCTT
TTGCTGTGCACATACGGGCTCTGACTGGTTTTAATAGTCACCTTCATGATTATAGCAACTAATGTTTGAACAAAGCTCAAAGTATGCAAT
GCTTCATTATTCAAGAATGAAAAATATAATGTTGATAATATATATTAAGTGTGCCAAATCAGTTTGACTACTCTCTGTTTTAGTGTTTAT
GTTTAAAAGAAATATATTTTTTGTTATTATTAGATAATATTTTTGTATTTCTCTATTTTCATAATCAGTAAATAGTGTCATATAAACTCA
TTTATCTCCTCTTCATGGCATCTTCAATATGAATCTATAAGTAGTAAATCAGAAAGTAACAATCTATGGCTTATTTCTATGACAAATTCA
AGAGCTAGAAAAATAAAATGTTTCATTATGCACTTTTAGAAATGCATATTTGCCACAAAACCTGTATTACTGAATAATATCAAATAAAAT

>27403_27403_1_ERICH1-DPYD_ERICH1_chr8_618598_ENST00000262109_DPYD_chr1_97700550_ENST00000370192_length(amino acids)=686AA_BP=427
MRSAAGSRMAAHRKHVFVEKVLQRLFPPVPSGQGKREPQTLAVQNPPKKVTSEKVSQKHAEPLTDTGSETPTARRLYTASGPPEGYVPCW
PEPSSCGSPENASSGDDTEDQDPHDQPKRRRIRKHKSKKKFKNPNNVLIEQAELEKQQSLLQEKSQRQHTDGTTISKNKKRKLKKKQQIK
RKKAAGLAAKAAGVSFMYQPEDSSNEGEGVGEACEEDGVDTSEEDPTLAGEEDVKDTREEDGADASEEDLTRARQEEGADASEEDPTPAG
EEDVKDAREEDGVDTIEEDLTRAGEEDGKDTREEDGADASEEDPTWAGEEEGADSGEEDGADASEEDDTITNEKAHSILNFLKSTQEMYF
YDGVSRDAASAALADAAEELLDRLASHSMLPSDVSILYHMKTLLLLQDTERLKHALEMFPEHCTMPPGTAIRPIALRAVTSIARALPGFP
ILATGGIDSAESGLQFLHSGASVLQVCSAIQNQDFTVIEDYCTGLKALLYLKSIEELQDWDGQSPATVSHQKGKPVPRIAELMDKKLPSF
GPYLEQRKKIIAENKIRLKEQNVAFSPLKRNCFIPKRPIPTIKDVIGKALQYLGTFGELSNVEQVVAMIDEEMCINCGKCYMTCNDSGYQ

--------------------------------------------------------------
>27403_27403_2_ERICH1-DPYD_ERICH1_chr8_618598_ENST00000522706_DPYD_chr1_97700550_ENST00000370192_length(transcript)=3024nt_BP=1012nt
GCGCGCCGTGGTCTGAGGTCCGCGGCAGGGTCCCGCATGGCGGCGCACAGGAAGCACGATCAGGATCCTCATGACCAGCCAAAGAGAAGA
AGAATTAGGAAGCATAAATCAAAGAAAAAATTTAAAAATCCCAATAATGTTCTTATAGAACAAGCAGAATTAGAGAAACAGCAGAGTCTG
TTACAGGAGAAATCTCAGCGACAGCACACAGATGGCACCACAATAAGCAAAAATAAAAAAAGGAAACTGAAAAAGAAACAGCAAATTAAA
AGGAAGAAAGCAGCCGGCTTGGCAGCAAAGGCTGCTGGTGTCAGTTTCATGTACCAGCCCGAGGACAGCAGCAATGAAGGGGAAGGCGTG
GGAGAGGCTTGTGAGGAGGATGGTGTGGACACCAGCGAGGAAGACCCGACACTGGCCGGGGAGGAAGACGTTAAAGATACCAGGGAGGAA
GATGGTGCGGACGCTAGCGAGGAAGACCTGACACGGGCCAGGCAGGAAGAGGGTGCGGACGCCAGTGAGGAAGATCCGACACCGGCCGGG
GAGGAAGACGTTAAAGACGCCAGGGAGGAGGACGGTGTGGACACCATTGAGGAAGACCTGACACGGGCCGGGGAGGAAGACGGTAAAGAC
ACCAGGGAGGAGGACGGTGCGGACGCCAGCGAGGAAGACCCGACATGGGCTGGGGAGGAAGAGGGTGCAGACTCCGGGGAGGAGGACGGT
GCAGACGCCAGCGAGGAAGATGATACAATTACCAATGAAAAGGCACACAGTATTCTAAATTTTTTGAAGTCAACACAGGAAATGTATTTT
TATGACGGTGTCTCCAGAGATGCAGCTTCAGCTGCCCTCGCAGATGCCGCTGAGGAGCTGCTGGACCGCCTTGCGTCACACAGCATGCTG
CCCTCAGACGTGTCCATCCTGTACCACATGAAAACGCTGCTGCTCCTGCAAGATACTGAGAGATTGAAGCATGCTCTGGAAATGTTCCCA
GAACATTGCACGATGCCTCCTGGGACAGCAATCAGACCTATTGCTTTGAGAGCTGTGACCTCCATTGCTCGTGCTCTGCCTGGATTTCCC
ATTTTGGCTACTGGTGGAATTGACTCTGCTGAAAGTGGTCTTCAGTTTCTCCATAGTGGTGCTTCCGTCCTCCAGGTATGCAGTGCCATT
CAGAATCAGGATTTCACTGTGATCGAAGACTACTGCACTGGCCTCAAAGCCCTGCTTTATCTGAAAAGCATTGAAGAACTACAAGACTGG
GATGGACAGAGTCCAGCTACTGTGAGTCACCAGAAAGGGAAACCAGTTCCACGTATAGCTGAACTCATGGACAAGAAACTGCCAAGTTTT
GGACCTTATCTGGAACAGCGCAAGAAAATCATAGCAGAAAACAAGATTAGACTGAAAGAACAAAATGTAGCTTTTTCACCACTTAAGAGA
AACTGTTTTATCCCCAAAAGGCCTATTCCTACCATCAAGGATGTAATAGGAAAAGCACTGCAGTACCTTGGAACATTTGGTGAATTGAGC
AACGTAGAGCAAGTTGTGGCTATGATTGATGAAGAAATGTGTATCAACTGTGGTAAATGCTACATGACCTGTAATGATTCTGGCTACCAG
GCTATACAGTTTGATCCAGAAACCCACCTGCCCACCATAACCGACACTTGTACAGGCTGTACTCTGTGTCTCAGTGTTTGCCCTATTGTC
GACTGCATCAAAATGGTTTCCAGGACAACACCTTATGAACCAAAGAGAGGCGTACCCTTATCTGTGAATCCGGTGTGTTAAGGTGATTTG
TGAAACAGTTGCTGTGAACTTTCATGTCACCTACATATGCTGATCTTTTAAAATCATGATCCTTGTGTTCAGCTCTTTCCAAATTAAAAC
AAATATACATTTTCTAAATAAAAATATGTAATTTCAAAATACATTTGTAAGTGTAAAAAATGTCTCATGTCAATGACCATTCAATTAGTG
GTCATAAAATAGAATAATTCTTTTCTGAGGATAGTAGTTAAATAACTGTGTGGCAGTTAATTGGATGTTCACTGCCAGTTGTCTTATGTG
AAAAATTAACTTTTTTGTGGCAATTAGTGTGACAGTTTCCAAATTGCCCTATGCTGTGCTCCATATTTGATTTCTAATTGTAAGTGAAAT
TAAGCATTTTGAAACAAAGTACTCTTTAACATACAAGAAAATGTATCCAAGGAAACATTTTATCATTAAAAATTACCTTTAATTTTAATG
CTGTTTCTAAGAAAATGTAGTTAGCTCCATAAAGTACAAATGAAGAAAGTCAAAAAATTATTTGCTATGGCAGGATAAGAAAGCCTAAAA
TTGAGTTTGTAGAACTTTATTAAGTAAAATCCCCTTCGCTGAAATTGCTTATTTTTGGTGTTGGATAGAGGATAGGGAGAATATTTACTA
ACTAAATACCATTCACTACTCATGCGTGAGATGGGTGTACAAACTCATCCTCTTTTAATGGCATTTCTCTTTAAACTATGTTCCTAACAA
AATGAGATGATAGGATAGATCCTGGTTACCACTCTTTTGCTGTGCACATACGGGCTCTGACTGGTTTTAATAGTCACCTTCATGATTATA
GCAACTAATGTTTGAACAAAGCTCAAAGTATGCAATGCTTCATTATTCAAGAATGAAAAATATAATGTTGATAATATATATTAAGTGTGC
CAAATCAGTTTGACTACTCTCTGTTTTAGTGTTTATGTTTAAAAGAAATATATTTTTTGTTATTATTAGATAATATTTTTGTATTTCTCT
ATTTTCATAATCAGTAAATAGTGTCATATAAACTCATTTATCTCCTCTTCATGGCATCTTCAATATGAATCTATAAGTAGTAAATCAGAA
AGTAACAATCTATGGCTTATTTCTATGACAAATTCAAGAGCTAGAAAAATAAAATGTTTCATTATGCACTTTTAGAAATGCATATTTGCC

>27403_27403_2_ERICH1-DPYD_ERICH1_chr8_618598_ENST00000522706_DPYD_chr1_97700550_ENST00000370192_length(amino acids)=592AA_BP=333
MRSAAGSRMAAHRKHDQDPHDQPKRRRIRKHKSKKKFKNPNNVLIEQAELEKQQSLLQEKSQRQHTDGTTISKNKKRKLKKKQQIKRKKA
AGLAAKAAGVSFMYQPEDSSNEGEGVGEACEEDGVDTSEEDPTLAGEEDVKDTREEDGADASEEDLTRARQEEGADASEEDPTPAGEEDV
KDAREEDGVDTIEEDLTRAGEEDGKDTREEDGADASEEDPTWAGEEEGADSGEEDGADASEEDDTITNEKAHSILNFLKSTQEMYFYDGV
SRDAASAALADAAEELLDRLASHSMLPSDVSILYHMKTLLLLQDTERLKHALEMFPEHCTMPPGTAIRPIALRAVTSIARALPGFPILAT
GGIDSAESGLQFLHSGASVLQVCSAIQNQDFTVIEDYCTGLKALLYLKSIEELQDWDGQSPATVSHQKGKPVPRIAELMDKKLPSFGPYL
EQRKKIIAENKIRLKEQNVAFSPLKRNCFIPKRPIPTIKDVIGKALQYLGTFGELSNVEQVVAMIDEEMCINCGKCYMTCNDSGYQAIQF

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for ERICH1-DPYD

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for ERICH1-DPYD

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for ERICH1-DPYD

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source