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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ERICH1-PTPRR (FusionGDB2 ID:27409)

Fusion Gene Summary for ERICH1-PTPRR

check button Fusion gene summary
Fusion gene informationFusion gene name: ERICH1-PTPRR
Fusion gene ID: 27409
HgeneTgene
Gene symbol

ERICH1

PTPRR

Gene ID

157697

5801

Gene nameglutamate rich 1protein tyrosine phosphatase receptor type R
SynonymsHSPC319EC-PTP|PCPTP1|PTP-SL|PTPBR7|PTPRQ
Cytomap

8p23.3

12q15

Type of geneprotein-codingprotein-coding
Descriptionglutamate-rich protein 1receptor-type tyrosine-protein phosphatase RCh-1 PTPaseNC-PTPCOM1R-PTP-Rch-1PTPaseprotein tyrosine phosphatase Cr1PTPaseprotein-tyrosine phosphatase NC-PTPCOM1protein-tyrosine phosphatase PCPTP1
Modification date2020031320200313
UniProtAcc

Q86X53

.
Ensembl transtripts involved in fusion geneENST00000262109, ENST00000518277, 
ENST00000522706, 
ENST00000342084, 
ENST00000378778, ENST00000440835, 
ENST00000537619, ENST00000549308, 
ENST00000283228, 
Fusion gene scores* DoF score8 X 6 X 6=28838 X 16 X 13=7904
# samples 842
** MAII scorelog2(8/288*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(42/7904*10)=-4.23412171391856
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ERICH1 [Title/Abstract] AND PTPRR [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointERICH1(642478)-PTPRR(71286757), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ERICH1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PTPRR (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-ER-A2NE-06AERICH1chr8

642478

-PTPRRchr12

71286757

-


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Fusion Gene ORF analysis for ERICH1-PTPRR

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000262109ENST00000342084ERICH1chr8

642478

-PTPRRchr12

71286757

-
5CDS-intronENST00000262109ENST00000378778ERICH1chr8

642478

-PTPRRchr12

71286757

-
5CDS-intronENST00000262109ENST00000440835ERICH1chr8

642478

-PTPRRchr12

71286757

-
5CDS-intronENST00000262109ENST00000537619ERICH1chr8

642478

-PTPRRchr12

71286757

-
5CDS-intronENST00000262109ENST00000549308ERICH1chr8

642478

-PTPRRchr12

71286757

-
5UTR-3CDSENST00000518277ENST00000283228ERICH1chr8

642478

-PTPRRchr12

71286757

-
5UTR-intronENST00000518277ENST00000342084ERICH1chr8

642478

-PTPRRchr12

71286757

-
5UTR-intronENST00000518277ENST00000378778ERICH1chr8

642478

-PTPRRchr12

71286757

-
5UTR-intronENST00000518277ENST00000440835ERICH1chr8

642478

-PTPRRchr12

71286757

-
5UTR-intronENST00000518277ENST00000537619ERICH1chr8

642478

-PTPRRchr12

71286757

-
5UTR-intronENST00000518277ENST00000549308ERICH1chr8

642478

-PTPRRchr12

71286757

-
In-frameENST00000262109ENST00000283228ERICH1chr8

642478

-PTPRRchr12

71286757

-
intron-3CDSENST00000522706ENST00000283228ERICH1chr8

642478

-PTPRRchr12

71286757

-
intron-intronENST00000522706ENST00000342084ERICH1chr8

642478

-PTPRRchr12

71286757

-
intron-intronENST00000522706ENST00000378778ERICH1chr8

642478

-PTPRRchr12

71286757

-
intron-intronENST00000522706ENST00000440835ERICH1chr8

642478

-PTPRRchr12

71286757

-
intron-intronENST00000522706ENST00000537619ERICH1chr8

642478

-PTPRRchr12

71286757

-
intron-intronENST00000522706ENST00000549308ERICH1chr8

642478

-PTPRRchr12

71286757

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000262109ERICH1chr8642478-ENST00000283228PTPRRchr1271286757-3400382542297747

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000262109ENST00000283228ERICH1chr8642478-PTPRRchr1271286757-0.0003290020.999671

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Fusion Genomic Features for ERICH1-PTPRR


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ERICH1-PTPRR


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:642478/chr12:71286757)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ERICH1

Q86X53

.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePTPRRchr8:642478chr12:71286757ENST00000283228014393_64719658.0DomainTyrosine-protein phosphatase
TgenePTPRRchr8:642478chr12:71286757ENST00000342084013393_6470546.0DomainTyrosine-protein phosphatase
TgenePTPRRchr8:642478chr12:71286757ENST00000378778011393_6470452.0DomainTyrosine-protein phosphatase
TgenePTPRRchr8:642478chr12:71286757ENST00000440835010393_6470413.0DomainTyrosine-protein phosphatase
TgenePTPRRchr8:642478chr12:71286757ENST00000549308011393_6470413.0DomainTyrosine-protein phosphatase
TgenePTPRRchr8:642478chr12:71286757ENST00000283228014588_59419658.0RegionSubstrate binding
TgenePTPRRchr8:642478chr12:71286757ENST00000342084013588_5940546.0RegionSubstrate binding
TgenePTPRRchr8:642478chr12:71286757ENST00000378778011588_5940452.0RegionSubstrate binding
TgenePTPRRchr8:642478chr12:71286757ENST00000440835010588_5940413.0RegionSubstrate binding
TgenePTPRRchr8:642478chr12:71286757ENST00000549308011588_5940413.0RegionSubstrate binding
TgenePTPRRchr8:642478chr12:71286757ENST0000028322801422_22719658.0Topological domainExtracellular
TgenePTPRRchr8:642478chr12:71286757ENST00000283228014249_65719658.0Topological domainCytoplasmic
TgenePTPRRchr8:642478chr12:71286757ENST0000034208401322_2270546.0Topological domainExtracellular
TgenePTPRRchr8:642478chr12:71286757ENST00000342084013249_6570546.0Topological domainCytoplasmic
TgenePTPRRchr8:642478chr12:71286757ENST0000037877801122_2270452.0Topological domainExtracellular
TgenePTPRRchr8:642478chr12:71286757ENST00000378778011249_6570452.0Topological domainCytoplasmic
TgenePTPRRchr8:642478chr12:71286757ENST0000044083501022_2270413.0Topological domainExtracellular
TgenePTPRRchr8:642478chr12:71286757ENST00000440835010249_6570413.0Topological domainCytoplasmic
TgenePTPRRchr8:642478chr12:71286757ENST0000054930801122_2270413.0Topological domainExtracellular
TgenePTPRRchr8:642478chr12:71286757ENST00000549308011249_6570413.0Topological domainCytoplasmic
TgenePTPRRchr8:642478chr12:71286757ENST00000283228014228_24819658.0TransmembraneHelical
TgenePTPRRchr8:642478chr12:71286757ENST00000342084013228_2480546.0TransmembraneHelical
TgenePTPRRchr8:642478chr12:71286757ENST00000378778011228_2480452.0TransmembraneHelical
TgenePTPRRchr8:642478chr12:71286757ENST00000440835010228_2480413.0TransmembraneHelical
TgenePTPRRchr8:642478chr12:71286757ENST00000549308011228_2480413.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneERICH1chr8:642478chr12:71286757ENST00000262109-36193_328101444.0Compositional biasNote=Glu-rich


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Fusion Gene Sequence for ERICH1-PTPRR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>27409_27409_1_ERICH1-PTPRR_ERICH1_chr8_642478_ENST00000262109_PTPRR_chr12_71286757_ENST00000283228_length(transcript)=3400nt_BP=382nt
AGGAGGGCGGAACCCGGAAGGCACGGCGCTCAGCTCAGGACCGCGCGCCGTGGTCTGAGGTCCGCGGCAGGGTCCCGCATGGCGGCGCAC
AGGAAGCACGTGTTTGTGGAGAAGGTGCTGCAGAGACTTTTTCCTCCTGTTCCAAGTGGCCAAGGAAAGAGGGAACCCCAGACGCTGGCC
GTCCAAAATCCACCAAAGAAAGTGACCTCTGAGAAAGTGAGCCAGAAACATGCTGAGCCTTTGACAGACACTGGCTCTGAGACCCCGACT
GCCCGACGGCTCTACACTGCCAGCGGGCCTCCTGAGGGCTACGTCCCCTGTTGGCCGGAGCCCAGCAGCTGTGGGAGCCCCGAGAACGCC
TCCAGCGGGGATGACACAGAAGGGTGCTTTTCAGGAAACAATGATCATTTTTTGGCAATTAATCAGAAGAAGAGTGGGAAGCCGGTATTC
ATTTATAAGCATTCACAAGACATTGAGAAGAGCCTGGATATAGCCCCACAAAAAATCTACAGACATAGCTACCATTCCTCTTCCGAAGCT
CAAGTAAGCAAACGCCACCAGATTGTCAATTCAGCATTTCCTAGACCCGCATATGACCCGTCTCTCAATCTGCTGGCCATGGATGGTCAA
GATCTTGAAGTGGAAAATCTCCCAATCCCAGCAGCAAATGTAATTGTGGTGACACTGCAAATGGATGTAAACAAGCTGAACATAACCTTG
CTTCGGATCTTCCGCCAAGGAGTGGCTGCAGCTTTAGGACTCTTACCCCAGCAAGTGCACATCAATCGCCTCATTGGAAAGAAGAACAGT
ATTGAACTGTTTGTGTCTCCCATAAACCGAAAAACAGGAATTTCTGATGCTCTGCCCTCTGAGGAAGTTCTTCGTTCACTTAATATCAAT
GTTTTGCATCAAAGTTTATCCCAGTTTGGAATTACAGAAGTCTCTCCTGAGAAAAATGTTTTACAAGGGCAGCATGAAGCGGACAAAATC
TGGAGCAAAGAAGGATTTTATGCTGTTGTCATTTTTCTCAGCATCTTTGTTATTATAGTAACGTGTTTGATGATTCTTTACAGATTAAAA
GAAAGATTTCAGCTTTCCTTAAGACAAGACAAAGAGAAAAACCAGGAGATCCACCTATCGCCCATCACATTACAGCCAGCACTGTCCGAG
GCAAAGACAGTCCACAGCATGGTCCAACCTGAGCAGGCCCCAAAGGTACTGAATGTTGTCGTGGACCCTCAAGGCCGAGGTGCTCCTGAG
ATCAAAGCTACCACCGCTACCTCTGTTTGCCCTTCTCCTTTCAAAATGAAGCCCATAGGACTTCAAGAGAGAAGAGGGTCCAACGTATCT
CTTACATTGGACATGAGTAGCTTGGGGAACATTGAACCCTTTGTGTCTATACCAACACCACGGGAGAAGGTAGCAATGGAGTATCTGCAG
TCAGCCAGCCGAATTCTCACAAGGTCTCAGCTGAGGGACGTCGTGGCAAGTTCACATTTACTCCAAAGTGAATTCATGGAAATACCAATG
AACTTTGTGGATCCCAAAGAAATTGATATTCCGCGTCATGGAACTAAAAATCGCTATAAGACCATTTTACCAAATCCCCTCAGCAGAGTG
TGTTTAAGACCAAAAAATGTAACCGATTCATTGAGCACCTACATTAATGCTAATTATATTAGGGGCTACAGTGGCAAGGAGAAAGCCTTC
ATTGCCACGCAGGGCCCCATGATCAACACCGTGGATGATTTCTGGCAGATGGTTTGGCAGGAAGACAGCCCTGTGATTGTTATGATCACA
AAACTCAAAGAAAAAAATGAGAAATGTGTGCTATACTGGCCGGAAAAGAGAGGGATATATGGAAAAGTTGAGGTTCTGGTTATCAGTGTA
AATGAATGTGATAACTACACCATTCGAAACCTTGTCTTAAAGCAAGGAAGCCACACCCAACATGTGAAGCATTACTGGTACACCTCATGG
CCTGATCACAAGACTCCAGACAGTGCCCAGCCCCTCCTACAGCTCATGCTGGATGTAGAAGAAGACAGACTTGCTTCCCAGGGCCGAGGG
CCTGTGGTTGTCCACTGCAGTGCAGGAATAGGTAGAACAGGGTGTTTTATTGCTACATCCATTGGCTGTCAACAGCTGAAAGAAGAAGGA
GTTGTGGATGCACTAAGCATTGTCTGCCAGCTTCGTATGGATAGAGGTGGAATGGTGCAAACCAGTGAGCAGTATGAATTTGTGCACCAT
GCTCTGTGCCTGTATGAGAGCAGACTTTCAGCAGAGACTGTCCAGTGAGTCATTGAAGACTTGTCAGACCATCAATCTCTTGGGGTGATT
AATCAAATTACCCACCCAAGGCTTCTAGAAGGAGCTTCCTGCAATGGAAGGAAGGAGAAGCTCTGAAGCCCATGTATGGCATGGATTGTG
GAAGACTGGGCAACATATTTAAGATTTCCAGCTCCTTGTGTATATGAATGCATTTGTAAGCATCCCCCAAATTATTCTGAAGGTTTTTTG
ATGATGGAGGTATGATAGGTTTATCACACAGCCTAAGGCAGATTTTGTTTTGTCTGTACTGACTCTATCTGCCACACAGAATGTATGTAT
GTAATATTCAGTAATAAATGTCATCAGGTGATGACTGGATGAGCTGCTGAAGACATTCGTATTATGTGTTAGATGCTTTAATGTTTGCAA
AATCTGTCTTGTGAATGGACTGTCAGCTGTTAAACTGTTCCTGTTTTGAAGTGCTATTACCTTTCTCAGTTACCAGAATCTTGCTGCTAA
AGTTGCAAGTGATTGATAATGGATTTTTAACAGAGAAGTCTTTGTTTTTGAAAAACAAAAATCAAAAACAGTAACTATTTTATATGGAAA
TGTGTCTTGATAATATTACCTATTAAATGTGTATTTATAGTCCCTCCTATCAAACAATTACAGAGCACAATGATTGTCATTGGGTATATA
TGTATTTACTCTCTATTATTGGGCATAAAGGTGGCTTCTGCTCCAGAACTCTATCCACTGTATTTCCACATCGTGAGTCATTTTACTTTA
AAAGGGAAAAACAAATTTGTAGCAACTCTGAAGTATCAAGAGTTTTAACTACTTGTCTCTCTTTTGCTAAGAAGGGATTTTTGAATATGC
TATCTACCTGGAATCTCTCTCTCAACAAAAGGTATATGCCTTCAGGAATGATATAATCTGTCCCATTTTCGAGGCTCCTTATAAGGACAT
TTCCATGTATGTCCTTACATTTCTGAAAGCTTTCAATCTTCAAGAGACAAAAAAAATTAAAATAACTACCCTCAGCAAACACTAGCTGTT

>27409_27409_1_ERICH1-PTPRR_ERICH1_chr8_642478_ENST00000262109_PTPRR_chr12_71286757_ENST00000283228_length(amino acids)=747AA_BP=109
MRSAAGSRMAAHRKHVFVEKVLQRLFPPVPSGQGKREPQTLAVQNPPKKVTSEKVSQKHAEPLTDTGSETPTARRLYTASGPPEGYVPCW
PEPSSCGSPENASSGDDTEGCFSGNNDHFLAINQKKSGKPVFIYKHSQDIEKSLDIAPQKIYRHSYHSSSEAQVSKRHQIVNSAFPRPAY
DPSLNLLAMDGQDLEVENLPIPAANVIVVTLQMDVNKLNITLLRIFRQGVAAALGLLPQQVHINRLIGKKNSIELFVSPINRKTGISDAL
PSEEVLRSLNINVLHQSLSQFGITEVSPEKNVLQGQHEADKIWSKEGFYAVVIFLSIFVIIVTCLMILYRLKERFQLSLRQDKEKNQEIH
LSPITLQPALSEAKTVHSMVQPEQAPKVLNVVVDPQGRGAPEIKATTATSVCPSPFKMKPIGLQERRGSNVSLTLDMSSLGNIEPFVSIP
TPREKVAMEYLQSASRILTRSQLRDVVASSHLLQSEFMEIPMNFVDPKEIDIPRHGTKNRYKTILPNPLSRVCLRPKNVTDSLSTYINAN
YIRGYSGKEKAFIATQGPMINTVDDFWQMVWQEDSPVIVMITKLKEKNEKCVLYWPEKRGIYGKVEVLVISVNECDNYTIRNLVLKQGSH
TQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRLASQGRGPVVVHCSAGIGRTGCFIATSIGCQQLKEEGVVDALSIVCQLRMDRGGM

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Fusion Gene PPI Analysis for ERICH1-PTPRR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ERICH1-PTPRR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ERICH1-PTPRR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource