Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ERLIN1-DOCK1 (FusionGDB2 ID:27420)

Fusion Gene Summary for ERLIN1-DOCK1

Fusion gene summary

Fusion gene information	Fusion gene name: ERLIN1-DOCK1
	Fusion gene ID: 27420
		Hgene	Tgene
	Gene symbol	ERLIN1	DOCK1
	Gene ID	10613	1793
	Gene name	ER lipid raft associated 1	dedicator of cytokinesis 1
	Synonyms	C10orf69\|Erlin-1\|KE04\|KEO4\|SPFH1\|SPG62	DOCK180\|ced5
	Cytomap	10q24.31	10q26.2
	Type of gene	protein-coding	protein-coding
	Description	erlin-1Band_7 23-211 Keo4 (Interim) similar to C.elegans protein C42C1.9SPFH domain family, member 1SPFH domain-containing protein 1endoplasmic reticulum lipid raft-associated protein 1stomatin-prohibitin-flotillin-HflC/K domain-containing protein 1	dedicator of cytokinesis protein 1180 kDa protein downstream of CRKDOwnstream of CrK
	Modification date	20200313	20200327
	UniProtAcc	O75477	Q5JSL3
	Ensembl transtripts involved in fusion gene	ENST00000407654, ENST00000421367,	ENST00000484400, ENST00000280333,
Fusion gene scores	* DoF score	6 X 6 X 5=180	16 X 15 X 8=1920
	# samples	6	16
	** MAII score	log2(6/180*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(16/1920*10)=-3.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ERLIN1 [Title/Abstract] AND DOCK1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ERLIN1(101933965)-DOCK1(129201319), # samples:3
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ERLIN1	GO:0030433	ubiquitin-dependent ERAD pathway	19240031

Fusion gene breakpoints across ERLIN1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across DOCK1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	DLBC	TCGA-VB-A8QN-01A	ERLIN1	chr10	101933965	-	DOCK1	chr10	129201319	+
ChimerDB4	DLBC	TCGA-VB-A8QN	ERLIN1	chr10	101933965	-	DOCK1	chr10	129201319	+

Top

Fusion Gene ORF analysis for ERLIN1-DOCK1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000407654	ENST00000484400	ERLIN1	chr10	101933965	-	DOCK1	chr10	129201319	+
5CDS-intron	ENST00000421367	ENST00000484400	ERLIN1	chr10	101933965	-	DOCK1	chr10	129201319	+
In-frame	ENST00000407654	ENST00000280333	ERLIN1	chr10	101933965	-	DOCK1	chr10	129201319	+
In-frame	ENST00000421367	ENST00000280333	ERLIN1	chr10	101933965	-	DOCK1	chr10	129201319	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000421367

ERLIN1

chr10

101933965

ENST00000280333

DOCK1

chr10

129201319

6036

3212

2708

4945

745

ENST00000407654

ERLIN1

chr10

101933965

ENST00000280333

DOCK1

chr10

129201319

3411

587

2320

772

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000421367	ENST00000280333	ERLIN1	chr10	101933965	-	DOCK1	chr10	129201319	+	0.000377695	0.9996222
ENST00000407654	ENST00000280333	ERLIN1	chr10	101933965	-	DOCK1	chr10	129201319	+	0.000715491	0.99928457

Top

Fusion Genomic Features for ERLIN1-DOCK1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
ERLIN1	chr10	101933964	-	DOCK1	chr10	129201318	+	7.05E-06	0.99999297
ERLIN1	chr10	101933964	-	DOCK1	chr10	129201318	+	7.05E-06	0.99999297
ERLIN1	chr10	101933964	-	DOCK1	chr10	129201318	+	7.05E-06	0.99999297
ERLIN1	chr10	101933964	-	DOCK1	chr10	129201318	+	7.05E-06	0.99999297

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for ERLIN1-DOCK1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:101933965/chr10:129201319)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ERLIN1 O75477	DOCK1 Q5JSL3
FUNCTION: Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. Binds cholesterol and may promote ER retention of the SCAP-SREBF complex (PubMed:24217618). {ECO:0000269\|PubMed:19240031, ECO:0000269\|PubMed:24217618}.; FUNCTION: (Microbial infection) Required early in hepatitis C virus (HCV) infection to initiate RNA replication, and later in the infection to support infectious virus production. {ECO:0000269\|PubMed:31810281}.	FUNCTION: Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Required for marginal zone (MZ) B-cell development, is associated with early bone marrow B-cell development, MZ B-cell formation, MZ B-cell number and marginal metallophilic macrophages morphology. Facilitates filopodia formation through the activation of CDC42. {ECO:0000250\|UniProtKB:A2AF47}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ERLIN1

chr10:101933965

chr10:129201319

ENST00000407654

1_7

168

349.0

Topological domain

Cytoplasmic

Hgene

ERLIN1

chr10:101933965

chr10:129201319

ENST00000421367

1_7

168

349.0

Topological domain

Cytoplasmic

Hgene

ERLIN1

chr10:101933965

chr10:129201319

ENST00000407654

8_28

168

349.0

Transmembrane

Helical

Hgene

ERLIN1

chr10:101933965

chr10:129201319

ENST00000421367

8_28

168

349.0

Transmembrane

Helical

Tgene

DOCK1

chr10:101933965

chr10:129201319

ENST00000280333

1687_1695

1288

1866.0

Region

Phosphoinositide-binding

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ERLIN1

chr10:101933965

chr10:129201319

ENST00000407654

29_348

168

349.0

Topological domain

Lumenal

Hgene

ERLIN1

chr10:101933965

chr10:129201319

ENST00000421367

29_348

168

349.0

Topological domain

Lumenal

Tgene

DOCK1

chr10:101933965

chr10:129201319

ENST00000280333

1207_1617

1288

1866.0

Domain

DOCKER

Tgene

DOCK1

chr10:101933965

chr10:129201319

ENST00000280333

425_609

1288

1866.0

Domain

C2 DOCK-type

Tgene

DOCK1

chr10:101933965

chr10:129201319

ENST00000280333

9_70

1288

1866.0

Domain

SH3

Top

Fusion Gene Sequence for ERLIN1-DOCK1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>27420_27420_1_ERLIN1-DOCK1_ERLIN1_chr10_101933965_ENST00000407654_DOCK1_chr10_129201319_ENST00000280333_length(transcript)=3411nt_BP=587nt
GGCTGTTGGCGGCGGTTGGCTCGGCGCGGGAGTCGGCTGCACGTGCGGGCGGGGGCGATGCGTCACTGATCGGAGGAACGAGAATGAATA
TGACTCAAGCCCGGGTTCTGGTGGCTGCAGTGGTGGGGTTGGTGGCTGTCCTGCTCTACGCCTCCATCCACAAGATTGAGGAGGGCCATC
TGGCTGTGTACTACAGGGGAGGAGCTTTACTAACTAGCCCCAGTGGACCAGGCTATCATATCATGTTGCCTTTCATTACTACGTTCAGAT
CTGTGCAGACAACACTACAAACTGATGAAGTTAAAAATGTGCCTTGTGGAACAAGTGGTGGGGTCATGATCTATATTGACCGAATAGAAG
TGGTTAATATGTTGGCTCCTTATGCAGTGTTTGATATCGTGAGGAACTATACTGCAGATTATGACAAGACCTTAATCTTCAATAAAATCC
ACCATGAGCTGAACCAGTTCTGCAGTGCCCACACACTTCAGGAAGTTTACATTGAATTGTTTGATCAAATAGATGAAAACCTGAAGCAAG
CTCTGCAGAAAGACTTAAACCTCATGGCCCCAGGTCTCACTATACAGATGTGGGAGGAGGCCATTGCCTTGGGCAAGGAGCTAGCCGAGC
AGTATGAGAACGAAATGTTTGATTATGAGCAACTCAGCGAATTGCTGAAAAAACAGGCTCAGTTTTATGAAAACATCGTCAAAGTGATCA
GGCCCAAGCCTGACTATTTTGCTGTTGGCTACTACGGACAAGGGTTCCCCACATTCCTGCGGGGAAAAGTTTTCATTTACCGAGGGAAAG
AGTATGAGCGCCGGGAAGATTTTGAGGCTCGGCTCTTAACTCAGTTTCCAAACGCCGAGAAAATGAAGACAACATCTCCACCAGGCGACG
ATATTAAAAACTCTCCTGGCCAGTATATTCAGTGCTTCACAGTGAAGCCCAAACTCGATCTGCCTCCTAAGTTTCACAGGCCAGTGTCAG
AGCAGATTGTAAGTTTTTACAGGGTGAACGAGGTCCAGCGATTTGAATATTCTCGGCCAATCCGGAAGGGAGAGAAAAACCCAGACAATG
AATTTGCGAATATGTGGATCGAGAGAACCATATATACAACTGCATATAAATTACCTGGAATTTTAAGGTGGTTTGAGGTCAAGTCTGTTT
TCATGGTGGAAATCAGCCCCCTGGAGAATGCCATTGAGACCATGCAGCTGACGAACGACAAGATCAACAGCATGGTGCAGCAGCACCTGG
ATGACCCCAGCCTGCCCATCAACCCGCTCTCCATGCTCCTGAACGGCATCGTGGACCCAGCTGTCATGGGGGGCTTCGCAAACTACGAAA
AGGCCTTCTTTACAGACCGGTACCTGCAGGAGCACCCTGAGGCCCATGAAAAGATCGAGAAGCTCAAGGACCTGATTGCTTGGCAGATTC
CTTTTCTGGCCGAAGGGATCAGAATCCATGGAGACAAAGTCACGGAGGCACTGAGGCCGTTCCACGAGAGGATGGAGGCCTGTTTCAAAC
AGCTGAAGGAAAAGGTGGAGAAAGAGTACGGCGTCCGAATCATGCCCTCAAGTCTGGATGATAGAAGAGGCAGCCGCCCCCGGTCCATGG
TGCGGTCCTTCACGATGCCTTCCTCATCCCGCCCTCTGTCTGTGGCCTCTGTCTCTTCCCTCTCATCGGACAGCACCCCTTCCAGACCAG
GCTCCGACGGGTTTGCCCTGGAGCCTCTCCTGCCAAAGAAAATGCACTCCAGGTCCCAGGACAAGCTGGACAAGGATGACCTGGAGAAGG
AGAAGAAGGACAAGAAGAAGGAAAAAAGGAACAGCAAACATCAAGAGATATTTGAGAAAGAATTTAAACCCACCGACATTTCCCTGCAGC
AGTCTGAGGCTGTGATCCTTTCGGAAACGATAAGTCCCCTGCGGCCCCAGAGACCGAAGAGCCAGGTGATGAACGTCATTGGAAGCGAAA
GGCGCTTCTCGGTGTCCCCCTCGTCACCGTCCTCCCAGCAAACACCCCCTCCAGTTACACCAAGGGCCAAGCTCAGCTTCAGCATGCAGT
CGAGCTTGGAGCTGAACGGCATGACGGGGGCGGACGTGGCCGATGTCCCACCCCCTCTGCCTCTCAAAGGCAGCGTGGCAGATTACGGGA
ATTTGATGGAAAACCAGGACTTGCTGGGCTCGCCAACACCTCCACCTCCCCCTCCACACCAGAGGCATCTGCCACCTCCACTGCCCAGCA
AAACTCCGCCTCCTCCCCCTCCAAAGACAACTCGCAAGCAGGCATCGGTGGACTCCGGGATCGTGCAGTGACGTCGCAAGCCTCTCTGGA
AAGAGTGTGCTGCCCCTCCCCATCTCCATGCCCTCTCCTTCTGTGTCCCCTGAGTCTGCTGTTTACCTCATTGGGCCTGTGATGTTAACA
TTTCGTGCGACTGCTTTTTCTTCAAAGGAGTTCAGTTCTCACCATGGAGTGAGTGGCCTTTAGCGTCATGGAGCAAGGTGGGTCTGGGAG
GTAGATATGGGTCCGGGATGTGCTATCGTAGTTATCAGAGTTGGGGGCCTCTGAGTGTGTCTGGCTCTGAGAGAGTCTGAGTCTTGCCCA
AACATTCTTTCTTTTTGTGCCAAATGACTTGCATTTGCAAAGAGCTCAATTGCTCTGAGCTCAGCCAAGTAGGAGAGGCTAGGCCATCAC
TCTTAGGAAGCTGTGTAGTGATGATGTATAAGAATCCTCCTCACTGTCATGGGATGTTGTATCCAGCCCCTCCTTGTTCCAGCCGGTGGT
GTGACTTCGTTGGTTGAGGTGTGTCTCCAACCTACATCAGACCATGAAGTTCAACCCCTCCAGGGAAGCTCCTGATTTCCCCTGCATAAT
TGAAAATAGGATATTTCTCAGCTATTGAACAGTTACTAATTTATGGGGTGGAAACAGCATTAAGAATACTGAATCAAATGGAAAAACAAA
TGAATACAGGAAGATAAGTGTTCGTTCTTTTCTGAAAAAGAGTATGTGTACCACAAGAGCTGGTTTTAATTGGGTGAATTGTTTTTGTCC
TCATTCTGTACAGAAATTTGTATATATGATGGTTCTTAGAACTTGTTTTAATTTTTGTGGTCCTTCCGTTTATTATAATAGGCGTCCACC
AATGATTATCCATATGTGTTCTTAATTTTTAACTGCTGGAAGTGTTAAAACACACACACACACACACACACATTTTTTTTTTGAGAACTC
CAAAGTCCTGAAAATTTTGGTGGACAATGATTTTTAAAAAACTAACTTTGTATAACCTAATATTTGTATTCTCTCATCTATATTTTTTTA

>27420_27420_1_ERLIN1-DOCK1_ERLIN1_chr10_101933965_ENST00000407654_DOCK1_chr10_129201319_ENST00000280333_length(amino acids)=772AA_BP=194
LLAAVGSARESAARAGGGDASLIGGTRMNMTQARVLVAAVVGLVAVLLYASIHKIEEGHLAVYYRGGALLTSPSGPGYHIMLPFITTFRS
VQTTLQTDEVKNVPCGTSGGVMIYIDRIEVVNMLAPYAVFDIVRNYTADYDKTLIFNKIHHELNQFCSAHTLQEVYIELFDQIDENLKQA
LQKDLNLMAPGLTIQMWEEAIALGKELAEQYENEMFDYEQLSELLKKQAQFYENIVKVIRPKPDYFAVGYYGQGFPTFLRGKVFIYRGKE
YERREDFEARLLTQFPNAEKMKTTSPPGDDIKNSPGQYIQCFTVKPKLDLPPKFHRPVSEQIVSFYRVNEVQRFEYSRPIRKGEKNPDNE
FANMWIERTIYTTAYKLPGILRWFEVKSVFMVEISPLENAIETMQLTNDKINSMVQQHLDDPSLPINPLSMLLNGIVDPAVMGGFANYEK
AFFTDRYLQEHPEAHEKIEKLKDLIAWQIPFLAEGIRIHGDKVTEALRPFHERMEACFKQLKEKVEKEYGVRIMPSSLDDRRGSRPRSMV
RSFTMPSSSRPLSVASVSSLSSDSTPSRPGSDGFALEPLLPKKMHSRSQDKLDKDDLEKEKKDKKKEKRNSKHQEIFEKEFKPTDISLQQ
SEAVILSETISPLRPQRPKSQVMNVIGSERRFSVSPSSPSSQQTPPPVTPRAKLSFSMQSSLELNGMTGADVADVPPPLPLKGSVADYGN

--------------------------------------------------------------
>27420_27420_2_ERLIN1-DOCK1_ERLIN1_chr10_101933965_ENST00000421367_DOCK1_chr10_129201319_ENST00000280333_length(transcript)=6036nt_BP=3212nt
ATTATAATAAAACAGTTGAATATGGCTTAGGAAAATATGAAGGTTCCATGAAGTGGAATTAAGAGCATAGAATAACTGTACTTTCCTTAG
GAATAATAGGACTTATGGTAAAGGTAGTATTGGGCAACTTCTTTAAGAGTGTTTTCCTCTGAGATGTCCTATCACCACTATCTACATCTA
AAAAACATGCTCGATTCTTGCCCTATAAACTGATGTCACAGCCCCACCATCCCCATTTTTGCTAGTGGTATCATTTTCCTAGTCAACCAA
ATTTTTTAGTCATCACATATCACTGTTCGTCATCTATTATAATAGGCAGTCTCTCTCTTGTTTCCCTGGTTTTAGAAGATTTTAGTAATA
AACATTTATTGGGTACCTGTTACTTGGAGGGTATTAAGCTAGATGGCAAGATCTGAAACAACATAGGCAGTATAGTAAAAGTGCTTATCT
GGGAGTCTGAACATTACAAGCCATCCAAGCATTGCAATTATTGTTAAGGATTATTTTCAATGGTCATGCATTTTCTAATATTTTAATAAT
TGGTTAAAGATTTGTTATAGCGTGGGGGCCGCTGCTGGTGTGTGGCTGGGGTTATGTCAGGGCAGCCTGATCTATATAATTTGGGCAGAT
GGTGTGAGTCAGAACAGACTATTATAGTGGGATCCCCAAACTTGCTTTTGATGCATGAGTTGGACCACTATTTTTTGGTGGGTAACAACT
TTTCAGAGGGGAATGGCAGTTGTGAATTGTATACATTTCATTCTTTAAGCAATATTATGAAAAACTTCAGAGAATGTCTACAGAAAACAG
GGTATGGAGCAAGTTATTTTCCATTCTTTTTGCTTTTTGGAAGTTAAAATAGCTAAGCTCTGCAAATATCATTTATTTGGAACAGATAAG
GTCCCAGACATTCCTAGATAATAAAAATCAAATGAATGATACAGGTAAGTGTATTTATTGAAGGGTGTGGGTAGAGTGGTCTGGGAAGTC
TTGCTTTAATGAAGACGGATTGATTCTATTTACCTCTTCTTACTTCCACTACTAAGTAACCCTGGGCCTGCAGTTTCCTAACCACTTGAC
TTCCTTGCCAACAGTCTGTCTCCACTTTCAGCCGTTTTATAGATTCATTGGCCCTAAAGCACTGCTTTCCCATACTTCCCTACCCAAGAG
GGCAGGGGTCCCCAAGCCCTGGGCCGCGGACCGGAACCAGACAGTGGCCTGTTAGGAACCAAGCCGGATAGCAGGAGGTGAGCGGCGGGC
GAGTGAGCATTATCGCCTTGAGCTCTGCCTGCTGTCAGATTAGCGAGTGGCATCAGATTCTCATAGGCACGCGAACCCTATTGTGAACTG
CACATGTGAGGTTTGCCGGCTCCCTGTGAGAATCTAATGCCTGATGATCTGAAGTGGAACAGTTTCATCCCCAACCCACACACACCCCCA
CCCCGTCCGCTGGGTTAGAGGACTTTACAACCCTAGTCCACCTTGTCCAGTTATAGTTCCACCTCTAGCCTTTCAAGGCTTAAACCATTA
ATGTCCTTAATTTCTCTTGTATTCATCTATCTCCCAACTATACCTTTTTCCTTCCCTTTTTTATTTTTGGCAATATGTGCCCATGGTTTT
TTAATTTAAAACGAACAGAATATGTAGTGACGCCTACCATAGCACTCCTTCCCATCACACAAGCCTTCAAGGAAACTGAAGTACTTACTT
TGGTCTCCCTGGAGGATTCCCTCCGCCTCCCGCCCCATGTGCTTAGCAATTCTGTTCCTGTAGTCTGGATGGCCTTCATAAAGCCCTCAC
TGGACCAGCATTCTGGCACATAATAGGAACACTTAAAAAACGAGAGAATGATGCCGTTATATCTAATATCTTCCTCTTCTGAACTTTCAC
AGCACTTTATTTGCAACAAGTTTAGTTGCTCCTGAAGGGCAGGATCTCTGCCGGAAGCAAGTGCGTGCCACACAGTGGGGCTCCGCATAC
ACTGCAAAAGGACAAATAAACCGAACAGCTACCGTTTGAGAGTGAGCGAGTGGGTTCTCTGCACAAGAACAAACCAACCAGTCCCTTGTC
CGAAAGGGCGTCTCCTTTTCTCTGCTTCGCTGCTCACTCCAGACTGCGGGCTGTCCTCTTCCGAAGCAGTTAACCAGCAGTGTACAGAAA
GCGACTTGCCTCCAAAGGAGCCTGCGCGGCCCGCGGCTAGGAGAATTTTGTCCCATGCGCTCCCCGTCTCACTAGCCGCGGGCCGGGGCT
ACGCCGTGTGCGTCCCCGCGCAGCCGCAGTGCTGGGCGAGTGGGCGGGGCCGGCTGTTGGCGGCGGTTGGCTCGGCGCGGGAGTCGGCTG
CACGTGCGGGCGGGGGCGATGCGTCACTGATCGGTGAGGCGCGGCCGAGGGGTCGGCTTTCCTCGCGAGCCTGCGGCTGGGCTTCTTCTC
AGTTAGTGCCTTCCACCCGGGAGCGACCCTTGGGAGAGGGAGTTTCAGGAAGCTCACCGAGCAGGGGCGGCCCACTGGCCTCCGGGGGCG
GAGGAGTTGGCAAGGGGTCAGCGGGCTCAGCCAGAAGGGAAGAATGAGGGGACAGGGGTACTGGACTCCCCGGCTCAGCCTGCGAGAGAG
CGCCAAGTTTCCGGAGGGAGAGGGTAGAAACTGGAGGGGGTGGACCTGTCACTCACGGGACTGAGGGTCCTTTTCTCCCGCTCCCAGGAG
GAACGAGAATGAATATGACTCAAGCCCGGGTTCTGGTGGCTGCAGTGGTGGGGTTGGTGGCTGTCCTGCTCTACGCCTCCATCCACAAGA
TTGAGGAGGGCCATCTGGCTGTGTACTACAGGGGAGGAGCTTTACTAACTAGCCCCAGTGGACCAGGCTATCATATCATGTTGCCTTTCA
TTACTACGTTCAGATCTGTGCAGACAACACTACAAACTGATGAAGTTAAAAATGTGCCTTGTGGAACAAGTGGTGGGGTCATGATCTATA
TTGACCGAATAGAAGTGGTTAATATGTTGGCTCCTTATGCAGTGTTTGATATCGTGAGGAACTATACTGCAGATTATGACAAGACCTTAA
TCTTCAATAAAATCCACCATGAGCTGAACCAGTTCTGCAGTGCCCACACACTTCAGGAAGTTTACATTGAATTGTTTGATCAAATAGATG
AAAACCTGAAGCAAGCTCTGCAGAAAGACTTAAACCTCATGGCCCCAGGTCTCACTATACAGATGTGGGAGGAGGCCATTGCCTTGGGCA
AGGAGCTAGCCGAGCAGTATGAGAACGAAATGTTTGATTATGAGCAACTCAGCGAATTGCTGAAAAAACAGGCTCAGTTTTATGAAAACA
TCGTCAAAGTGATCAGGCCCAAGCCTGACTATTTTGCTGTTGGCTACTACGGACAAGGGTTCCCCACATTCCTGCGGGGAAAAGTTTTCA
TTTACCGAGGGAAAGAGTATGAGCGCCGGGAAGATTTTGAGGCTCGGCTCTTAACTCAGTTTCCAAACGCCGAGAAAATGAAGACAACAT
CTCCACCAGGCGACGATATTAAAAACTCTCCTGGCCAGTATATTCAGTGCTTCACAGTGAAGCCCAAACTCGATCTGCCTCCTAAGTTTC
ACAGGCCAGTGTCAGAGCAGATTGTAAGTTTTTACAGGGTGAACGAGGTCCAGCGATTTGAATATTCTCGGCCAATCCGGAAGGGAGAGA
AAAACCCAGACAATGAATTTGCGAATATGTGGATCGAGAGAACCATATATACAACTGCATATAAATTACCTGGAATTTTAAGGTGGTTTG
AGGTCAAGTCTGTTTTCATGGTGGAAATCAGCCCCCTGGAGAATGCCATTGAGACCATGCAGCTGACGAACGACAAGATCAACAGCATGG
TGCAGCAGCACCTGGATGACCCCAGCCTGCCCATCAACCCGCTCTCCATGCTCCTGAACGGCATCGTGGACCCAGCTGTCATGGGGGGCT
TCGCAAACTACGAAAAGGCCTTCTTTACAGACCGGTACCTGCAGGAGCACCCTGAGGCCCATGAAAAGATCGAGAAGCTCAAGGACCTGA
TTGCTTGGCAGATTCCTTTTCTGGCCGAAGGGATCAGAATCCATGGAGACAAAGTCACGGAGGCACTGAGGCCGTTCCACGAGAGGATGG
AGGCCTGTTTCAAACAGCTGAAGGAAAAGGTGGAGAAAGAGTACGGCGTCCGAATCATGCCCTCAAGTCTGGATGATAGAAGAGGCAGCC
GCCCCCGGTCCATGGTGCGGTCCTTCACGATGCCTTCCTCATCCCGCCCTCTGTCTGTGGCCTCTGTCTCTTCCCTCTCATCGGACAGCA
CCCCTTCCAGACCAGGCTCCGACGGGTTTGCCCTGGAGCCTCTCCTGCCAAAGAAAATGCACTCCAGGTCCCAGGACAAGCTGGACAAGG
ATGACCTGGAGAAGGAGAAGAAGGACAAGAAGAAGGAAAAAAGGAACAGCAAACATCAAGAGATATTTGAGAAAGAATTTAAACCCACCG
ACATTTCCCTGCAGCAGTCTGAGGCTGTGATCCTTTCGGAAACGATAAGTCCCCTGCGGCCCCAGAGACCGAAGAGCCAGGTGATGAACG
TCATTGGAAGCGAAAGGCGCTTCTCGGTGTCCCCCTCGTCACCGTCCTCCCAGCAAACACCCCCTCCAGTTACACCAAGGGCCAAGCTCA
GCTTCAGCATGCAGTCGAGCTTGGAGCTGAACGGCATGACGGGGGCGGACGTGGCCGATGTCCCACCCCCTCTGCCTCTCAAAGGCAGCG
TGGCAGATTACGGGAATTTGATGGAAAACCAGGACTTGCTGGGCTCGCCAACACCTCCACCTCCCCCTCCACACCAGAGGCATCTGCCAC
CTCCACTGCCCAGCAAAACTCCGCCTCCTCCCCCTCCAAAGACAACTCGCAAGCAGGCATCGGTGGACTCCGGGATCGTGCAGTGACGTC
GCAAGCCTCTCTGGAAAGAGTGTGCTGCCCCTCCCCATCTCCATGCCCTCTCCTTCTGTGTCCCCTGAGTCTGCTGTTTACCTCATTGGG
CCTGTGATGTTAACATTTCGTGCGACTGCTTTTTCTTCAAAGGAGTTCAGTTCTCACCATGGAGTGAGTGGCCTTTAGCGTCATGGAGCA
AGGTGGGTCTGGGAGGTAGATATGGGTCCGGGATGTGCTATCGTAGTTATCAGAGTTGGGGGCCTCTGAGTGTGTCTGGCTCTGAGAGAG
TCTGAGTCTTGCCCAAACATTCTTTCTTTTTGTGCCAAATGACTTGCATTTGCAAAGAGCTCAATTGCTCTGAGCTCAGCCAAGTAGGAG
AGGCTAGGCCATCACTCTTAGGAAGCTGTGTAGTGATGATGTATAAGAATCCTCCTCACTGTCATGGGATGTTGTATCCAGCCCCTCCTT
GTTCCAGCCGGTGGTGTGACTTCGTTGGTTGAGGTGTGTCTCCAACCTACATCAGACCATGAAGTTCAACCCCTCCAGGGAAGCTCCTGA
TTTCCCCTGCATAATTGAAAATAGGATATTTCTCAGCTATTGAACAGTTACTAATTTATGGGGTGGAAACAGCATTAAGAATACTGAATC
AAATGGAAAAACAAATGAATACAGGAAGATAAGTGTTCGTTCTTTTCTGAAAAAGAGTATGTGTACCACAAGAGCTGGTTTTAATTGGGT
GAATTGTTTTTGTCCTCATTCTGTACAGAAATTTGTATATATGATGGTTCTTAGAACTTGTTTTAATTTTTGTGGTCCTTCCGTTTATTA
TAATAGGCGTCCACCAATGATTATCCATATGTGTTCTTAATTTTTAACTGCTGGAAGTGTTAAAACACACACACACACACACACACATTT
TTTTTTTGAGAACTCCAAAGTCCTGAAAATTTTGGTGGACAATGATTTTTAAAAAACTAACTTTGTATAACCTAATATTTGTATTCTCTC
ATCTATATTTTTTTATTCACTATAATCATGATACTCTTCTAATAGACTTAAAAGTTAATCATTGACAACGAAAAATAAAATGTTATTTTA

>27420_27420_2_ERLIN1-DOCK1_ERLIN1_chr10_101933965_ENST00000421367_DOCK1_chr10_129201319_ENST00000280333_length(amino acids)=745AA_BP=167
MNMTQARVLVAAVVGLVAVLLYASIHKIEEGHLAVYYRGGALLTSPSGPGYHIMLPFITTFRSVQTTLQTDEVKNVPCGTSGGVMIYIDR
IEVVNMLAPYAVFDIVRNYTADYDKTLIFNKIHHELNQFCSAHTLQEVYIELFDQIDENLKQALQKDLNLMAPGLTIQMWEEAIALGKEL
AEQYENEMFDYEQLSELLKKQAQFYENIVKVIRPKPDYFAVGYYGQGFPTFLRGKVFIYRGKEYERREDFEARLLTQFPNAEKMKTTSPP
GDDIKNSPGQYIQCFTVKPKLDLPPKFHRPVSEQIVSFYRVNEVQRFEYSRPIRKGEKNPDNEFANMWIERTIYTTAYKLPGILRWFEVK
SVFMVEISPLENAIETMQLTNDKINSMVQQHLDDPSLPINPLSMLLNGIVDPAVMGGFANYEKAFFTDRYLQEHPEAHEKIEKLKDLIAW
QIPFLAEGIRIHGDKVTEALRPFHERMEACFKQLKEKVEKEYGVRIMPSSLDDRRGSRPRSMVRSFTMPSSSRPLSVASVSSLSSDSTPS
RPGSDGFALEPLLPKKMHSRSQDKLDKDDLEKEKKDKKKEKRNSKHQEIFEKEFKPTDISLQQSEAVILSETISPLRPQRPKSQVMNVIG
SERRFSVSPSSPSSQQTPPPVTPRAKLSFSMQSSLELNGMTGADVADVPPPLPLKGSVADYGNLMENQDLLGSPTPPPPPPHQRHLPPPL

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for ERLIN1-DOCK1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Tgene	DOCK1	chr10:101933965	chr10:129201319	ENST00000280333		37	52	1837_1852	1288.0	1866.0	NCK2 (minor)
Tgene	DOCK1	chr10:101933965	chr10:129201319	ENST00000280333		37	52	1793_1819	1288.0	1866.0	NCK2 second and third SH3 domain (minor)
Tgene	DOCK1	chr10:101933965	chr10:129201319	ENST00000280333		37	52	1820_1836	1288.0	1866.0	NCK2 third SH3 domain (major)

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for ERLIN1-DOCK1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for ERLIN1-DOCK1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source