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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ERP44-CCNB1IP1 (FusionGDB2 ID:27479)

Fusion Gene Summary for ERP44-CCNB1IP1

check button Fusion gene summary
Fusion gene informationFusion gene name: ERP44-CCNB1IP1
Fusion gene ID: 27479
HgeneTgene
Gene symbol

ERP44

CCNB1IP1

Gene ID

23071

57820

Gene nameendoplasmic reticulum protein 44cyclin B1 interacting protein 1
SynonymsPDIA10|TXNDC4C14orf18|HEI10
Cytomap

9q31.1

14q11.2

Type of geneprotein-codingprotein-coding
Descriptionendoplasmic reticulum resident protein 44ER protein 44endoplasmic reticulum resident protein 44 kDaepididymis secretory sperm binding proteinprotein disulfide isomerase family A, member 10thioredoxin domain containing 4 (endoplasmic reticulum)thioreE3 ubiquitin-protein ligase CCNB1IP1RING-type E3 ubiquitin transferase CCNB1IP1cyclin B1 interacting protein 1, E3 ubiquitin protein ligaseepididymis secretory sperm binding proteinhuman enhancer of invasion 10
Modification date2020031320200313
UniProtAcc

Q9BS26

Q9NPC3

Ensembl transtripts involved in fusion geneENST00000262455, ENST00000557114, 
ENST00000353689, ENST00000358932, 
ENST00000398160, ENST00000398163, 
ENST00000398169, ENST00000437553, 
Fusion gene scores* DoF score6 X 5 X 3=906 X 5 X 6=180
# samples 76
** MAII scorelog2(7/90*10)=-0.362570079384708
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/180*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ERP44 [Title/Abstract] AND CCNB1IP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointERP44(102778604)-CCNB1IP1(20781960), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneERP44

GO:0006457

protein folding

11847130

HgeneERP44

GO:0006986

response to unfolded protein

11847130

HgeneERP44

GO:0009100

glycoprotein metabolic process

11847130

HgeneERP44

GO:0034976

response to endoplasmic reticulum stress

11847130


check buttonFusion gene breakpoints across ERP44 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CCNB1IP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CD-A4MH-01AERP44chr9

102778604

-CCNB1IP1chr14

20781960

-


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Fusion Gene ORF analysis for ERP44-CCNB1IP1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000262455ENST00000557114ERP44chr9

102778604

-CCNB1IP1chr14

20781960

-
In-frameENST00000262455ENST00000353689ERP44chr9

102778604

-CCNB1IP1chr14

20781960

-
In-frameENST00000262455ENST00000358932ERP44chr9

102778604

-CCNB1IP1chr14

20781960

-
In-frameENST00000262455ENST00000398160ERP44chr9

102778604

-CCNB1IP1chr14

20781960

-
In-frameENST00000262455ENST00000398163ERP44chr9

102778604

-CCNB1IP1chr14

20781960

-
In-frameENST00000262455ENST00000398169ERP44chr9

102778604

-CCNB1IP1chr14

20781960

-
In-frameENST00000262455ENST00000437553ERP44chr9

102778604

-CCNB1IP1chr14

20781960

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000262455ERP44chr9102778604-ENST00000398160CCNB1IP1chr1420781960-1681962501498482
ENST00000262455ERP44chr9102778604-ENST00000398169CCNB1IP1chr1420781960-1679962501498482
ENST00000262455ERP44chr9102778604-ENST00000358932CCNB1IP1chr1420781960-1679962501498482
ENST00000262455ERP44chr9102778604-ENST00000437553CCNB1IP1chr1420781960-1678962501498482
ENST00000262455ERP44chr9102778604-ENST00000353689CCNB1IP1chr1420781960-1678962501498482
ENST00000262455ERP44chr9102778604-ENST00000398163CCNB1IP1chr1420781960-1620962501498482

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000262455ENST00000398160ERP44chr9102778604-CCNB1IP1chr1420781960-0.0001758490.9998242
ENST00000262455ENST00000398169ERP44chr9102778604-CCNB1IP1chr1420781960-0.0001761840.99982387
ENST00000262455ENST00000358932ERP44chr9102778604-CCNB1IP1chr1420781960-0.0001761840.99982387
ENST00000262455ENST00000437553ERP44chr9102778604-CCNB1IP1chr1420781960-0.0001789480.9998211
ENST00000262455ENST00000353689ERP44chr9102778604-CCNB1IP1chr1420781960-0.0001789480.9998211
ENST00000262455ENST00000398163ERP44chr9102778604-CCNB1IP1chr1420781960-0.0002029860.99979705

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Fusion Genomic Features for ERP44-CCNB1IP1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ERP44-CCNB1IP1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:102778604/chr14:20781960)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ERP44

Q9BS26

CCNB1IP1

Q9NPC3

FUNCTION: Mediates thiol-dependent retention in the early secretory pathway, forming mixed disulfides with substrate proteins through its conserved CRFS motif. Inhibits the calcium channel activity of ITPR1. May have a role in the control of oxidative protein folding in the endoplasmic reticulum. Required to retain ERO1A and ERO1B in the endoplasmic reticulum. {ECO:0000269|PubMed:11847130, ECO:0000269|PubMed:14517240}.FUNCTION: Ubiquitin E3 ligase that acts as a limiting factor for crossing-over during meiosis: required during zygonema to limit the colocalization of RNF212 with MutS-gamma-associated recombination sites and thereby establish early differentiation of crossover and non-crossover sites. Later, it is directed by MutL-gamma to stably accumulate at designated crossover sites. Probably promotes the dissociation of RNF212 and MutS-gamma to allow the progression of recombination and the implementation of the final steps of crossing over (By similarity). Modulates cyclin-B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis. {ECO:0000250, ECO:0000269|PubMed:12612082, ECO:0000269|PubMed:17297447}.; FUNCTION: E3 ubiquitin-protein ligase. Modulates cyclin B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneERP44chr9:102778604chr14:20781960ENST00000262455-81230_138254407.0DomainThioredoxin
TgeneCCNB1IP1chr9:102778604chr14:20781960ENST0000035368936127_18299278.0Coiled coilOntology_term=ECO:0000255
TgeneCCNB1IP1chr9:102778604chr14:20781960ENST0000035893247127_18299278.0Coiled coilOntology_term=ECO:0000255
TgeneCCNB1IP1chr9:102778604chr14:20781960ENST0000039816047127_18299278.0Coiled coilOntology_term=ECO:0000255
TgeneCCNB1IP1chr9:102778604chr14:20781960ENST0000039816347127_18299278.0Coiled coilOntology_term=ECO:0000255
TgeneCCNB1IP1chr9:102778604chr14:20781960ENST0000039816947127_18299278.0Coiled coilOntology_term=ECO:0000255
TgeneCCNB1IP1chr9:102778604chr14:20781960ENST0000043755347127_18299278.0Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneERP44chr9:102778604chr14:20781960ENST00000262455-812403_406254407.0MotifPrevents secretion from ER
TgeneCCNB1IP1chr9:102778604chr14:20781960ENST00000353689364_5199278.0Zinc fingerNote=RING-type%3B atypical
TgeneCCNB1IP1chr9:102778604chr14:20781960ENST00000358932474_5199278.0Zinc fingerNote=RING-type%3B atypical
TgeneCCNB1IP1chr9:102778604chr14:20781960ENST00000398160474_5199278.0Zinc fingerNote=RING-type%3B atypical
TgeneCCNB1IP1chr9:102778604chr14:20781960ENST00000398163474_5199278.0Zinc fingerNote=RING-type%3B atypical
TgeneCCNB1IP1chr9:102778604chr14:20781960ENST00000398169474_5199278.0Zinc fingerNote=RING-type%3B atypical
TgeneCCNB1IP1chr9:102778604chr14:20781960ENST00000437553474_5199278.0Zinc fingerNote=RING-type%3B atypical


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Fusion Gene Sequence for ERP44-CCNB1IP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>27479_27479_1_ERP44-CCNB1IP1_ERP44_chr9_102778604_ENST00000262455_CCNB1IP1_chr14_20781960_ENST00000353689_length(transcript)=1678nt_BP=962nt
GAAGTGAGGGTGTGAGAGGCCTCTCTGGAAGTTGTCCCGGGTGTTCGCCGCTGGAGCCCGGGTCGAGAGGACGAGGTGCCGCTGCCTGGA
GAATCCTCCGCTGCCGTCGGCTCCCGGAGCCCAGCCCTTTCCTAACCCAACCCAACCTAGCCCAGTCCCAGCCGCCAGCGCCTGTCCCTG
TCACGGACCCCAGCGTTACCATGCATCCTGCCGTCTTCCTATCCTTACCCGACCTCAGATGCTCCCTTCTGCTCCTGGTAACTTGGGTTT
TTACTCCTGTAACAACTGAAATAACAAGTCTTGATACAGAGAATATAGATGAAATTTTAAACAATGCTGATGTTGCTTTAGTAAATTTTT
ATGCTGACTGGTGTCGTTTCAGTCAGATGTTGCATCCAATTTTTGAGGAAGCTTCCGATGTCATTAAGGAAGAATTTCCAAATGAAAATC
AAGTAGTGTTTGCCAGAGTTGATTGTGATCAGCACTCTGACATAGCCCAGAGATACAGGATAAGCAAATACCCAACCCTCAAATTGTTTC
GTAATGGGATGATGATGAAGAGAGAATACAGGGGTCAGCGATCAGTGAAAGCATTGGCAGATTACATCAGGCAACAAAAAAGTGACCCCA
TTCAAGAAATTCGGGACTTAGCAGAAATCACCACTCTTGATCGCAGCAAAAGAAATATCATTGGATATTTTGAGCAAAAGGACTCGGACA
ACTATAGAGTTTTTGAACGAGTAGCGAATATTTTGCATGATGACTGTGCCTTTCTTTCTGCATTTGGGGATGTTTCAAAACCGGAAAGAT
ATAGTGGCGACAACATAATCTACAAACCACCAGGGCATTCTGCTCCGGATATGGTGTACTTGGGAGCTATGACAAATTTTGATGTGACTT
ACAATTGGATTCAAGATAAATGTGTTCCTCTTGTCCGAGAAATAACATTTGAAAATGGAGAGGTACATCAGGAACGTCTCTATCAAGAAT
ACAATTTCAGCAAGGCTGAGGGCCATCTGAAACAGATGGAGAAGATATATACTCAGCAAATACAAAGCAAGGATGTAGAATTGACCTCTA
TGAAAGGGGAGGTTACCTCCATGAAGAAAGTACTAGAAGAATACAAGAAAAAGTTCAGTGACATCTCTGAGAAACTTATGGAGCGCAATC
GTCAGTATCAAAAGCTCCAAGGCCTCTATGATAGCCTTAGGCTACGAAACATCACTATTGCTAACCATGAAGGCACCCTTGAACCATCCA
TGATTGCACAGTCTGGTGTTCTTGGCTTCCCATTAGGTAACAACTCCAAGTTTCCTTTGGATAATACACCTGTTCGAAATCGGGGCGATG
GAGATGGAGATTTTCAGTTCAGACCATTTTTTGCGGGTTCTCCCACAGCACCTGAACCCAGCAACAGCTTTTTTAGTTTTGTCTCTCCAA
GTCGTGAATTAGAGCAGCAGCAAGTTTCTAGCAGGGCCTTCAAAGTAAAAAGAATTTGAGCCACGCATAGTGTCACGCACCTGTGATCCC
AGCTACTTAGGAGGTTGAGGCTGGGAGGATCACTTGAGCCCAGGAGTCTGAGGCTTTAGTGATCTAAGATCATGCCACTGCACTCCAGCC

>27479_27479_1_ERP44-CCNB1IP1_ERP44_chr9_102778604_ENST00000262455_CCNB1IP1_chr14_20781960_ENST00000353689_length(amino acids)=482AA_BP=304
MEPGSRGRGAAAWRILRCRRLPEPSPFLTQPNLAQSQPPAPVPVTDPSVTMHPAVFLSLPDLRCSLLLLVTWVFTPVTTEITSLDTENID
EILNNADVALVNFYADWCRFSQMLHPIFEEASDVIKEEFPNENQVVFARVDCDQHSDIAQRYRISKYPTLKLFRNGMMMKREYRGQRSVK
ALADYIRQQKSDPIQEIRDLAEITTLDRSKRNIIGYFEQKDSDNYRVFERVANILHDDCAFLSAFGDVSKPERYSGDNIIYKPPGHSAPD
MVYLGAMTNFDVTYNWIQDKCVPLVREITFENGEVHQERLYQEYNFSKAEGHLKQMEKIYTQQIQSKDVELTSMKGEVTSMKKVLEEYKK
KFSDISEKLMERNRQYQKLQGLYDSLRLRNITIANHEGTLEPSMIAQSGVLGFPLGNNSKFPLDNTPVRNRGDGDGDFQFRPFFAGSPTA

--------------------------------------------------------------
>27479_27479_2_ERP44-CCNB1IP1_ERP44_chr9_102778604_ENST00000262455_CCNB1IP1_chr14_20781960_ENST00000358932_length(transcript)=1679nt_BP=962nt
GAAGTGAGGGTGTGAGAGGCCTCTCTGGAAGTTGTCCCGGGTGTTCGCCGCTGGAGCCCGGGTCGAGAGGACGAGGTGCCGCTGCCTGGA
GAATCCTCCGCTGCCGTCGGCTCCCGGAGCCCAGCCCTTTCCTAACCCAACCCAACCTAGCCCAGTCCCAGCCGCCAGCGCCTGTCCCTG
TCACGGACCCCAGCGTTACCATGCATCCTGCCGTCTTCCTATCCTTACCCGACCTCAGATGCTCCCTTCTGCTCCTGGTAACTTGGGTTT
TTACTCCTGTAACAACTGAAATAACAAGTCTTGATACAGAGAATATAGATGAAATTTTAAACAATGCTGATGTTGCTTTAGTAAATTTTT
ATGCTGACTGGTGTCGTTTCAGTCAGATGTTGCATCCAATTTTTGAGGAAGCTTCCGATGTCATTAAGGAAGAATTTCCAAATGAAAATC
AAGTAGTGTTTGCCAGAGTTGATTGTGATCAGCACTCTGACATAGCCCAGAGATACAGGATAAGCAAATACCCAACCCTCAAATTGTTTC
GTAATGGGATGATGATGAAGAGAGAATACAGGGGTCAGCGATCAGTGAAAGCATTGGCAGATTACATCAGGCAACAAAAAAGTGACCCCA
TTCAAGAAATTCGGGACTTAGCAGAAATCACCACTCTTGATCGCAGCAAAAGAAATATCATTGGATATTTTGAGCAAAAGGACTCGGACA
ACTATAGAGTTTTTGAACGAGTAGCGAATATTTTGCATGATGACTGTGCCTTTCTTTCTGCATTTGGGGATGTTTCAAAACCGGAAAGAT
ATAGTGGCGACAACATAATCTACAAACCACCAGGGCATTCTGCTCCGGATATGGTGTACTTGGGAGCTATGACAAATTTTGATGTGACTT
ACAATTGGATTCAAGATAAATGTGTTCCTCTTGTCCGAGAAATAACATTTGAAAATGGAGAGGTACATCAGGAACGTCTCTATCAAGAAT
ACAATTTCAGCAAGGCTGAGGGCCATCTGAAACAGATGGAGAAGATATATACTCAGCAAATACAAAGCAAGGATGTAGAATTGACCTCTA
TGAAAGGGGAGGTTACCTCCATGAAGAAAGTACTAGAAGAATACAAGAAAAAGTTCAGTGACATCTCTGAGAAACTTATGGAGCGCAATC
GTCAGTATCAAAAGCTCCAAGGCCTCTATGATAGCCTTAGGCTACGAAACATCACTATTGCTAACCATGAAGGCACCCTTGAACCATCCA
TGATTGCACAGTCTGGTGTTCTTGGCTTCCCATTAGGTAACAACTCCAAGTTTCCTTTGGATAATACACCTGTTCGAAATCGGGGCGATG
GAGATGGAGATTTTCAGTTCAGACCATTTTTTGCGGGTTCTCCCACAGCACCTGAACCCAGCAACAGCTTTTTTAGTTTTGTCTCTCCAA
GTCGTGAATTAGAGCAGCAGCAAGTTTCTAGCAGGGCCTTCAAAGTAAAAAGAATTTGAGCCACGCATAGTGTCACGCACCTGTGATCCC
AGCTACTTAGGAGGTTGAGGCTGGGAGGATCACTTGAGCCCAGGAGTCTGAGGCTTTAGTGATCTAAGATCATGCCACTGCACTCCAGCC

>27479_27479_2_ERP44-CCNB1IP1_ERP44_chr9_102778604_ENST00000262455_CCNB1IP1_chr14_20781960_ENST00000358932_length(amino acids)=482AA_BP=304
MEPGSRGRGAAAWRILRCRRLPEPSPFLTQPNLAQSQPPAPVPVTDPSVTMHPAVFLSLPDLRCSLLLLVTWVFTPVTTEITSLDTENID
EILNNADVALVNFYADWCRFSQMLHPIFEEASDVIKEEFPNENQVVFARVDCDQHSDIAQRYRISKYPTLKLFRNGMMMKREYRGQRSVK
ALADYIRQQKSDPIQEIRDLAEITTLDRSKRNIIGYFEQKDSDNYRVFERVANILHDDCAFLSAFGDVSKPERYSGDNIIYKPPGHSAPD
MVYLGAMTNFDVTYNWIQDKCVPLVREITFENGEVHQERLYQEYNFSKAEGHLKQMEKIYTQQIQSKDVELTSMKGEVTSMKKVLEEYKK
KFSDISEKLMERNRQYQKLQGLYDSLRLRNITIANHEGTLEPSMIAQSGVLGFPLGNNSKFPLDNTPVRNRGDGDGDFQFRPFFAGSPTA

--------------------------------------------------------------
>27479_27479_3_ERP44-CCNB1IP1_ERP44_chr9_102778604_ENST00000262455_CCNB1IP1_chr14_20781960_ENST00000398160_length(transcript)=1681nt_BP=962nt
GAAGTGAGGGTGTGAGAGGCCTCTCTGGAAGTTGTCCCGGGTGTTCGCCGCTGGAGCCCGGGTCGAGAGGACGAGGTGCCGCTGCCTGGA
GAATCCTCCGCTGCCGTCGGCTCCCGGAGCCCAGCCCTTTCCTAACCCAACCCAACCTAGCCCAGTCCCAGCCGCCAGCGCCTGTCCCTG
TCACGGACCCCAGCGTTACCATGCATCCTGCCGTCTTCCTATCCTTACCCGACCTCAGATGCTCCCTTCTGCTCCTGGTAACTTGGGTTT
TTACTCCTGTAACAACTGAAATAACAAGTCTTGATACAGAGAATATAGATGAAATTTTAAACAATGCTGATGTTGCTTTAGTAAATTTTT
ATGCTGACTGGTGTCGTTTCAGTCAGATGTTGCATCCAATTTTTGAGGAAGCTTCCGATGTCATTAAGGAAGAATTTCCAAATGAAAATC
AAGTAGTGTTTGCCAGAGTTGATTGTGATCAGCACTCTGACATAGCCCAGAGATACAGGATAAGCAAATACCCAACCCTCAAATTGTTTC
GTAATGGGATGATGATGAAGAGAGAATACAGGGGTCAGCGATCAGTGAAAGCATTGGCAGATTACATCAGGCAACAAAAAAGTGACCCCA
TTCAAGAAATTCGGGACTTAGCAGAAATCACCACTCTTGATCGCAGCAAAAGAAATATCATTGGATATTTTGAGCAAAAGGACTCGGACA
ACTATAGAGTTTTTGAACGAGTAGCGAATATTTTGCATGATGACTGTGCCTTTCTTTCTGCATTTGGGGATGTTTCAAAACCGGAAAGAT
ATAGTGGCGACAACATAATCTACAAACCACCAGGGCATTCTGCTCCGGATATGGTGTACTTGGGAGCTATGACAAATTTTGATGTGACTT
ACAATTGGATTCAAGATAAATGTGTTCCTCTTGTCCGAGAAATAACATTTGAAAATGGAGAGGTACATCAGGAACGTCTCTATCAAGAAT
ACAATTTCAGCAAGGCTGAGGGCCATCTGAAACAGATGGAGAAGATATATACTCAGCAAATACAAAGCAAGGATGTAGAATTGACCTCTA
TGAAAGGGGAGGTTACCTCCATGAAGAAAGTACTAGAAGAATACAAGAAAAAGTTCAGTGACATCTCTGAGAAACTTATGGAGCGCAATC
GTCAGTATCAAAAGCTCCAAGGCCTCTATGATAGCCTTAGGCTACGAAACATCACTATTGCTAACCATGAAGGCACCCTTGAACCATCCA
TGATTGCACAGTCTGGTGTTCTTGGCTTCCCATTAGGTAACAACTCCAAGTTTCCTTTGGATAATACACCTGTTCGAAATCGGGGCGATG
GAGATGGAGATTTTCAGTTCAGACCATTTTTTGCGGGTTCTCCCACAGCACCTGAACCCAGCAACAGCTTTTTTAGTTTTGTCTCTCCAA
GTCGTGAATTAGAGCAGCAGCAAGTTTCTAGCAGGGCCTTCAAAGTAAAAAGAATTTGAGCCACGCATAGTGTCACGCACCTGTGATCCC
AGCTACTTAGGAGGTTGAGGCTGGGAGGATCACTTGAGCCCAGGAGTCTGAGGCTTTAGTGATCTAAGATCATGCCACTGCACTCCAGCC

>27479_27479_3_ERP44-CCNB1IP1_ERP44_chr9_102778604_ENST00000262455_CCNB1IP1_chr14_20781960_ENST00000398160_length(amino acids)=482AA_BP=304
MEPGSRGRGAAAWRILRCRRLPEPSPFLTQPNLAQSQPPAPVPVTDPSVTMHPAVFLSLPDLRCSLLLLVTWVFTPVTTEITSLDTENID
EILNNADVALVNFYADWCRFSQMLHPIFEEASDVIKEEFPNENQVVFARVDCDQHSDIAQRYRISKYPTLKLFRNGMMMKREYRGQRSVK
ALADYIRQQKSDPIQEIRDLAEITTLDRSKRNIIGYFEQKDSDNYRVFERVANILHDDCAFLSAFGDVSKPERYSGDNIIYKPPGHSAPD
MVYLGAMTNFDVTYNWIQDKCVPLVREITFENGEVHQERLYQEYNFSKAEGHLKQMEKIYTQQIQSKDVELTSMKGEVTSMKKVLEEYKK
KFSDISEKLMERNRQYQKLQGLYDSLRLRNITIANHEGTLEPSMIAQSGVLGFPLGNNSKFPLDNTPVRNRGDGDGDFQFRPFFAGSPTA

--------------------------------------------------------------
>27479_27479_4_ERP44-CCNB1IP1_ERP44_chr9_102778604_ENST00000262455_CCNB1IP1_chr14_20781960_ENST00000398163_length(transcript)=1620nt_BP=962nt
GAAGTGAGGGTGTGAGAGGCCTCTCTGGAAGTTGTCCCGGGTGTTCGCCGCTGGAGCCCGGGTCGAGAGGACGAGGTGCCGCTGCCTGGA
GAATCCTCCGCTGCCGTCGGCTCCCGGAGCCCAGCCCTTTCCTAACCCAACCCAACCTAGCCCAGTCCCAGCCGCCAGCGCCTGTCCCTG
TCACGGACCCCAGCGTTACCATGCATCCTGCCGTCTTCCTATCCTTACCCGACCTCAGATGCTCCCTTCTGCTCCTGGTAACTTGGGTTT
TTACTCCTGTAACAACTGAAATAACAAGTCTTGATACAGAGAATATAGATGAAATTTTAAACAATGCTGATGTTGCTTTAGTAAATTTTT
ATGCTGACTGGTGTCGTTTCAGTCAGATGTTGCATCCAATTTTTGAGGAAGCTTCCGATGTCATTAAGGAAGAATTTCCAAATGAAAATC
AAGTAGTGTTTGCCAGAGTTGATTGTGATCAGCACTCTGACATAGCCCAGAGATACAGGATAAGCAAATACCCAACCCTCAAATTGTTTC
GTAATGGGATGATGATGAAGAGAGAATACAGGGGTCAGCGATCAGTGAAAGCATTGGCAGATTACATCAGGCAACAAAAAAGTGACCCCA
TTCAAGAAATTCGGGACTTAGCAGAAATCACCACTCTTGATCGCAGCAAAAGAAATATCATTGGATATTTTGAGCAAAAGGACTCGGACA
ACTATAGAGTTTTTGAACGAGTAGCGAATATTTTGCATGATGACTGTGCCTTTCTTTCTGCATTTGGGGATGTTTCAAAACCGGAAAGAT
ATAGTGGCGACAACATAATCTACAAACCACCAGGGCATTCTGCTCCGGATATGGTGTACTTGGGAGCTATGACAAATTTTGATGTGACTT
ACAATTGGATTCAAGATAAATGTGTTCCTCTTGTCCGAGAAATAACATTTGAAAATGGAGAGGTACATCAGGAACGTCTCTATCAAGAAT
ACAATTTCAGCAAGGCTGAGGGCCATCTGAAACAGATGGAGAAGATATATACTCAGCAAATACAAAGCAAGGATGTAGAATTGACCTCTA
TGAAAGGGGAGGTTACCTCCATGAAGAAAGTACTAGAAGAATACAAGAAAAAGTTCAGTGACATCTCTGAGAAACTTATGGAGCGCAATC
GTCAGTATCAAAAGCTCCAAGGCCTCTATGATAGCCTTAGGCTACGAAACATCACTATTGCTAACCATGAAGGCACCCTTGAACCATCCA
TGATTGCACAGTCTGGTGTTCTTGGCTTCCCATTAGGTAACAACTCCAAGTTTCCTTTGGATAATACACCTGTTCGAAATCGGGGCGATG
GAGATGGAGATTTTCAGTTCAGACCATTTTTTGCGGGTTCTCCCACAGCACCTGAACCCAGCAACAGCTTTTTTAGTTTTGTCTCTCCAA
GTCGTGAATTAGAGCAGCAGCAAGTTTCTAGCAGGGCCTTCAAAGTAAAAAGAATTTGAGCCACGCATAGTGTCACGCACCTGTGATCCC
AGCTACTTAGGAGGTTGAGGCTGGGAGGATCACTTGAGCCCAGGAGTCTGAGGCTTTAGTGATCTAAGATCATGCCACTGCACTCCAGCC

>27479_27479_4_ERP44-CCNB1IP1_ERP44_chr9_102778604_ENST00000262455_CCNB1IP1_chr14_20781960_ENST00000398163_length(amino acids)=482AA_BP=304
MEPGSRGRGAAAWRILRCRRLPEPSPFLTQPNLAQSQPPAPVPVTDPSVTMHPAVFLSLPDLRCSLLLLVTWVFTPVTTEITSLDTENID
EILNNADVALVNFYADWCRFSQMLHPIFEEASDVIKEEFPNENQVVFARVDCDQHSDIAQRYRISKYPTLKLFRNGMMMKREYRGQRSVK
ALADYIRQQKSDPIQEIRDLAEITTLDRSKRNIIGYFEQKDSDNYRVFERVANILHDDCAFLSAFGDVSKPERYSGDNIIYKPPGHSAPD
MVYLGAMTNFDVTYNWIQDKCVPLVREITFENGEVHQERLYQEYNFSKAEGHLKQMEKIYTQQIQSKDVELTSMKGEVTSMKKVLEEYKK
KFSDISEKLMERNRQYQKLQGLYDSLRLRNITIANHEGTLEPSMIAQSGVLGFPLGNNSKFPLDNTPVRNRGDGDGDFQFRPFFAGSPTA

--------------------------------------------------------------
>27479_27479_5_ERP44-CCNB1IP1_ERP44_chr9_102778604_ENST00000262455_CCNB1IP1_chr14_20781960_ENST00000398169_length(transcript)=1679nt_BP=962nt
GAAGTGAGGGTGTGAGAGGCCTCTCTGGAAGTTGTCCCGGGTGTTCGCCGCTGGAGCCCGGGTCGAGAGGACGAGGTGCCGCTGCCTGGA
GAATCCTCCGCTGCCGTCGGCTCCCGGAGCCCAGCCCTTTCCTAACCCAACCCAACCTAGCCCAGTCCCAGCCGCCAGCGCCTGTCCCTG
TCACGGACCCCAGCGTTACCATGCATCCTGCCGTCTTCCTATCCTTACCCGACCTCAGATGCTCCCTTCTGCTCCTGGTAACTTGGGTTT
TTACTCCTGTAACAACTGAAATAACAAGTCTTGATACAGAGAATATAGATGAAATTTTAAACAATGCTGATGTTGCTTTAGTAAATTTTT
ATGCTGACTGGTGTCGTTTCAGTCAGATGTTGCATCCAATTTTTGAGGAAGCTTCCGATGTCATTAAGGAAGAATTTCCAAATGAAAATC
AAGTAGTGTTTGCCAGAGTTGATTGTGATCAGCACTCTGACATAGCCCAGAGATACAGGATAAGCAAATACCCAACCCTCAAATTGTTTC
GTAATGGGATGATGATGAAGAGAGAATACAGGGGTCAGCGATCAGTGAAAGCATTGGCAGATTACATCAGGCAACAAAAAAGTGACCCCA
TTCAAGAAATTCGGGACTTAGCAGAAATCACCACTCTTGATCGCAGCAAAAGAAATATCATTGGATATTTTGAGCAAAAGGACTCGGACA
ACTATAGAGTTTTTGAACGAGTAGCGAATATTTTGCATGATGACTGTGCCTTTCTTTCTGCATTTGGGGATGTTTCAAAACCGGAAAGAT
ATAGTGGCGACAACATAATCTACAAACCACCAGGGCATTCTGCTCCGGATATGGTGTACTTGGGAGCTATGACAAATTTTGATGTGACTT
ACAATTGGATTCAAGATAAATGTGTTCCTCTTGTCCGAGAAATAACATTTGAAAATGGAGAGGTACATCAGGAACGTCTCTATCAAGAAT
ACAATTTCAGCAAGGCTGAGGGCCATCTGAAACAGATGGAGAAGATATATACTCAGCAAATACAAAGCAAGGATGTAGAATTGACCTCTA
TGAAAGGGGAGGTTACCTCCATGAAGAAAGTACTAGAAGAATACAAGAAAAAGTTCAGTGACATCTCTGAGAAACTTATGGAGCGCAATC
GTCAGTATCAAAAGCTCCAAGGCCTCTATGATAGCCTTAGGCTACGAAACATCACTATTGCTAACCATGAAGGCACCCTTGAACCATCCA
TGATTGCACAGTCTGGTGTTCTTGGCTTCCCATTAGGTAACAACTCCAAGTTTCCTTTGGATAATACACCTGTTCGAAATCGGGGCGATG
GAGATGGAGATTTTCAGTTCAGACCATTTTTTGCGGGTTCTCCCACAGCACCTGAACCCAGCAACAGCTTTTTTAGTTTTGTCTCTCCAA
GTCGTGAATTAGAGCAGCAGCAAGTTTCTAGCAGGGCCTTCAAAGTAAAAAGAATTTGAGCCACGCATAGTGTCACGCACCTGTGATCCC
AGCTACTTAGGAGGTTGAGGCTGGGAGGATCACTTGAGCCCAGGAGTCTGAGGCTTTAGTGATCTAAGATCATGCCACTGCACTCCAGCC

>27479_27479_5_ERP44-CCNB1IP1_ERP44_chr9_102778604_ENST00000262455_CCNB1IP1_chr14_20781960_ENST00000398169_length(amino acids)=482AA_BP=304
MEPGSRGRGAAAWRILRCRRLPEPSPFLTQPNLAQSQPPAPVPVTDPSVTMHPAVFLSLPDLRCSLLLLVTWVFTPVTTEITSLDTENID
EILNNADVALVNFYADWCRFSQMLHPIFEEASDVIKEEFPNENQVVFARVDCDQHSDIAQRYRISKYPTLKLFRNGMMMKREYRGQRSVK
ALADYIRQQKSDPIQEIRDLAEITTLDRSKRNIIGYFEQKDSDNYRVFERVANILHDDCAFLSAFGDVSKPERYSGDNIIYKPPGHSAPD
MVYLGAMTNFDVTYNWIQDKCVPLVREITFENGEVHQERLYQEYNFSKAEGHLKQMEKIYTQQIQSKDVELTSMKGEVTSMKKVLEEYKK
KFSDISEKLMERNRQYQKLQGLYDSLRLRNITIANHEGTLEPSMIAQSGVLGFPLGNNSKFPLDNTPVRNRGDGDGDFQFRPFFAGSPTA

--------------------------------------------------------------
>27479_27479_6_ERP44-CCNB1IP1_ERP44_chr9_102778604_ENST00000262455_CCNB1IP1_chr14_20781960_ENST00000437553_length(transcript)=1678nt_BP=962nt
GAAGTGAGGGTGTGAGAGGCCTCTCTGGAAGTTGTCCCGGGTGTTCGCCGCTGGAGCCCGGGTCGAGAGGACGAGGTGCCGCTGCCTGGA
GAATCCTCCGCTGCCGTCGGCTCCCGGAGCCCAGCCCTTTCCTAACCCAACCCAACCTAGCCCAGTCCCAGCCGCCAGCGCCTGTCCCTG
TCACGGACCCCAGCGTTACCATGCATCCTGCCGTCTTCCTATCCTTACCCGACCTCAGATGCTCCCTTCTGCTCCTGGTAACTTGGGTTT
TTACTCCTGTAACAACTGAAATAACAAGTCTTGATACAGAGAATATAGATGAAATTTTAAACAATGCTGATGTTGCTTTAGTAAATTTTT
ATGCTGACTGGTGTCGTTTCAGTCAGATGTTGCATCCAATTTTTGAGGAAGCTTCCGATGTCATTAAGGAAGAATTTCCAAATGAAAATC
AAGTAGTGTTTGCCAGAGTTGATTGTGATCAGCACTCTGACATAGCCCAGAGATACAGGATAAGCAAATACCCAACCCTCAAATTGTTTC
GTAATGGGATGATGATGAAGAGAGAATACAGGGGTCAGCGATCAGTGAAAGCATTGGCAGATTACATCAGGCAACAAAAAAGTGACCCCA
TTCAAGAAATTCGGGACTTAGCAGAAATCACCACTCTTGATCGCAGCAAAAGAAATATCATTGGATATTTTGAGCAAAAGGACTCGGACA
ACTATAGAGTTTTTGAACGAGTAGCGAATATTTTGCATGATGACTGTGCCTTTCTTTCTGCATTTGGGGATGTTTCAAAACCGGAAAGAT
ATAGTGGCGACAACATAATCTACAAACCACCAGGGCATTCTGCTCCGGATATGGTGTACTTGGGAGCTATGACAAATTTTGATGTGACTT
ACAATTGGATTCAAGATAAATGTGTTCCTCTTGTCCGAGAAATAACATTTGAAAATGGAGAGGTACATCAGGAACGTCTCTATCAAGAAT
ACAATTTCAGCAAGGCTGAGGGCCATCTGAAACAGATGGAGAAGATATATACTCAGCAAATACAAAGCAAGGATGTAGAATTGACCTCTA
TGAAAGGGGAGGTTACCTCCATGAAGAAAGTACTAGAAGAATACAAGAAAAAGTTCAGTGACATCTCTGAGAAACTTATGGAGCGCAATC
GTCAGTATCAAAAGCTCCAAGGCCTCTATGATAGCCTTAGGCTACGAAACATCACTATTGCTAACCATGAAGGCACCCTTGAACCATCCA
TGATTGCACAGTCTGGTGTTCTTGGCTTCCCATTAGGTAACAACTCCAAGTTTCCTTTGGATAATACACCTGTTCGAAATCGGGGCGATG
GAGATGGAGATTTTCAGTTCAGACCATTTTTTGCGGGTTCTCCCACAGCACCTGAACCCAGCAACAGCTTTTTTAGTTTTGTCTCTCCAA
GTCGTGAATTAGAGCAGCAGCAAGTTTCTAGCAGGGCCTTCAAAGTAAAAAGAATTTGAGCCACGCATAGTGTCACGCACCTGTGATCCC
AGCTACTTAGGAGGTTGAGGCTGGGAGGATCACTTGAGCCCAGGAGTCTGAGGCTTTAGTGATCTAAGATCATGCCACTGCACTCCAGCC

>27479_27479_6_ERP44-CCNB1IP1_ERP44_chr9_102778604_ENST00000262455_CCNB1IP1_chr14_20781960_ENST00000437553_length(amino acids)=482AA_BP=304
MEPGSRGRGAAAWRILRCRRLPEPSPFLTQPNLAQSQPPAPVPVTDPSVTMHPAVFLSLPDLRCSLLLLVTWVFTPVTTEITSLDTENID
EILNNADVALVNFYADWCRFSQMLHPIFEEASDVIKEEFPNENQVVFARVDCDQHSDIAQRYRISKYPTLKLFRNGMMMKREYRGQRSVK
ALADYIRQQKSDPIQEIRDLAEITTLDRSKRNIIGYFEQKDSDNYRVFERVANILHDDCAFLSAFGDVSKPERYSGDNIIYKPPGHSAPD
MVYLGAMTNFDVTYNWIQDKCVPLVREITFENGEVHQERLYQEYNFSKAEGHLKQMEKIYTQQIQSKDVELTSMKGEVTSMKKVLEEYKK
KFSDISEKLMERNRQYQKLQGLYDSLRLRNITIANHEGTLEPSMIAQSGVLGFPLGNNSKFPLDNTPVRNRGDGDGDFQFRPFFAGSPTA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ERP44-CCNB1IP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneERP44chr9:102778604chr14:20781960ENST00000262455-812236_285254.0407.0ITPR1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ERP44-CCNB1IP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ERP44-CCNB1IP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource