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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ESCO2-EPHX2 (FusionGDB2 ID:27516)

Fusion Gene Summary for ESCO2-EPHX2

check button Fusion gene summary
Fusion gene informationFusion gene name: ESCO2-EPHX2
Fusion gene ID: 27516
HgeneTgene
Gene symbol

ESCO2

EPHX2

Gene ID

157570

2053

Gene nameestablishment of sister chromatid cohesion N-acetyltransferase 2epoxide hydrolase 2
Synonyms2410004I17Rik|EFO2|EFO2p|RBS|hEFO2ABHD20|CEH|SEH
Cytomap

8p21.1

8p21.2-p21.1

Type of geneprotein-codingprotein-coding
DescriptionN-acetyltransferase ESCO2ECO1 homolog 2establishment factor-like protein 2bifunctional epoxide hydrolase 2epoxide hydrataseepoxide hydrolase 2, cytoplasmicepoxide hydrolase 2, cytosolicepoxide hydrolase, soluble
Modification date2020032820200327
UniProtAcc.

P34913

Ensembl transtripts involved in fusion geneENST00000305188, ENST00000397418, 
ENST00000523910, 		ENST00000520666, 
ENST00000380476, ENST00000517536, 
ENST00000518379, ENST00000521400, 
ENST00000521780, 
Fusion gene scores* DoF score3 X 3 X 3=274 X 4 X 3=48
# samples 34
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ESCO2 [Title/Abstract] AND EPHX2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointESCO2(27646495)-EPHX2(27394301), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneEPHX2

GO:0010628

positive regulation of gene expression

18974052

TgeneEPHX2

GO:0016311

dephosphorylation

12574508

TgeneEPHX2

GO:0042632

cholesterol homeostasis

18974052

TgeneEPHX2

GO:0046272

stilbene catabolic process

8342951

TgeneEPHX2

GO:0046839

phospholipid dephosphorylation

12574510

TgeneEPHX2

GO:0097176

epoxide metabolic process

22798687


check buttonFusion gene breakpoints across ESCO2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across EPHX2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-23-1027-01AESCO2chr8

27646495

-EPHX2chr8

27394301

+


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Fusion Gene ORF analysis for ESCO2-EPHX2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000305188ENST00000520666ESCO2chr8

27646495

-EPHX2chr8

27394301

+
5CDS-intronENST00000397418ENST00000520666ESCO2chr8

27646495

-EPHX2chr8

27394301

+
In-frameENST00000305188ENST00000380476ESCO2chr8

27646495

-EPHX2chr8

27394301

+
In-frameENST00000305188ENST00000517536ESCO2chr8

27646495

-EPHX2chr8

27394301

+
In-frameENST00000305188ENST00000518379ESCO2chr8

27646495

-EPHX2chr8

27394301

+
In-frameENST00000305188ENST00000521400ESCO2chr8

27646495

-EPHX2chr8

27394301

+
In-frameENST00000305188ENST00000521780ESCO2chr8

27646495

-EPHX2chr8

27394301

+
In-frameENST00000397418ENST00000380476ESCO2chr8

27646495

-EPHX2chr8

27394301

+
In-frameENST00000397418ENST00000517536ESCO2chr8

27646495

-EPHX2chr8

27394301

+
In-frameENST00000397418ENST00000518379ESCO2chr8

27646495

-EPHX2chr8

27394301

+
In-frameENST00000397418ENST00000521400ESCO2chr8

27646495

-EPHX2chr8

27394301

+
In-frameENST00000397418ENST00000521780ESCO2chr8

27646495

-EPHX2chr8

27394301

+
intron-3CDSENST00000523910ENST00000380476ESCO2chr8

27646495

-EPHX2chr8

27394301

+
intron-3CDSENST00000523910ENST00000517536ESCO2chr8

27646495

-EPHX2chr8

27394301

+
intron-3CDSENST00000523910ENST00000518379ESCO2chr8

27646495

-EPHX2chr8

27394301

+
intron-3CDSENST00000523910ENST00000521400ESCO2chr8

27646495

-EPHX2chr8

27394301

+
intron-3CDSENST00000523910ENST00000521780ESCO2chr8

27646495

-EPHX2chr8

27394301

+
intron-intronENST00000523910ENST00000520666ESCO2chr8

27646495

-EPHX2chr8

27394301

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000305188ESCO2chr827646495-ENST00000521400EPHX2chr827394301+30411501311998655
ENST00000305188ESCO2chr827646495-ENST00000517536EPHX2chr827394301+23961501311998655
ENST00000305188ESCO2chr827646495-ENST00000521780EPHX2chr827394301+23961501311998655
ENST00000305188ESCO2chr827646495-ENST00000380476EPHX2chr827394301+23901501311998655
ENST00000305188ESCO2chr827646495-ENST00000518379EPHX2chr827394301+23691501311998655
ENST00000397418ESCO2chr827646495-ENST00000521400EPHX2chr827394301+2721118113942309
ENST00000397418ESCO2chr827646495-ENST00000517536EPHX2chr827394301+2076118113942309
ENST00000397418ESCO2chr827646495-ENST00000521780EPHX2chr827394301+2076118113942309
ENST00000397418ESCO2chr827646495-ENST00000380476EPHX2chr827394301+2070118113942309
ENST00000397418ESCO2chr827646495-ENST00000518379EPHX2chr827394301+2049118113942309

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000305188ENST00000521400ESCO2chr827646495-EPHX2chr827394301+0.0023568470.9976432
ENST00000305188ENST00000517536ESCO2chr827646495-EPHX2chr827394301+0.0018086810.9981913
ENST00000305188ENST00000521780ESCO2chr827646495-EPHX2chr827394301+0.0018086810.9981913
ENST00000305188ENST00000380476ESCO2chr827646495-EPHX2chr827394301+0.0018056760.9981943
ENST00000305188ENST00000518379ESCO2chr827646495-EPHX2chr827394301+0.0018717960.99812824
ENST00000397418ENST00000521400ESCO2chr827646495-EPHX2chr827394301+0.0069647680.9930353
ENST00000397418ENST00000517536ESCO2chr827646495-EPHX2chr827394301+0.0065717630.9934282
ENST00000397418ENST00000521780ESCO2chr827646495-EPHX2chr827394301+0.0065717630.9934282
ENST00000397418ENST00000380476ESCO2chr827646495-EPHX2chr827394301+0.0067974090.99320257
ENST00000397418ENST00000518379ESCO2chr827646495-EPHX2chr827394301+0.0069027330.99309725

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Fusion Genomic Features for ESCO2-EPHX2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ESCO2-EPHX2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:27646495/chr8:27394301)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.EPHX2

P34913

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Bifunctional enzyme (PubMed:12574510). The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides (PubMed:12869654, PubMed:12574510, PubMed:22798687). Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides (By similarity). Also determines steady-state levels of physiological mediators (PubMed:12869654, PubMed:12574510, PubMed:22798687, PubMed:21217101). {ECO:0000250|UniProtKB:P80299, ECO:0000269|PubMed:12574508, ECO:0000269|PubMed:12574510, ECO:0000269|PubMed:12869654, ECO:0000269|PubMed:21217101, ECO:0000269|PubMed:22798687}.; FUNCTION: Bifunctional enzyme (PubMed:12574510). The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo-9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by erythro-9,10-phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy-octadec-9Z-enoic acid and 12-phosphonooxy-octadec-9E-enoic acid (PubMed:12574510). Has phosphatase activity toward lyso-glycerophospholipids with also some lower activity toward lysolipids of sphingolipid and isoprenoid phosphates (PubMed:22217705, PubMed:22387545). {ECO:0000269|PubMed:12574510, ECO:0000269|PubMed:22217705, ECO:0000269|PubMed:22387545}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneESCO2chr8:27646495chr8:27394301ENST00000305188-711387_411421602.0Zinc fingerNote=CCHH-type
TgeneEPHX2chr8:27646495chr8:27394301ENST000003804761119553_555337503.0MotifMicrobody targeting signal
TgeneEPHX2chr8:27646495chr8:27394301ENST000005214001119553_555390556.0MotifMicrobody targeting signal
TgeneEPHX2chr8:27646495chr8:27394301ENST000005217801018553_555324490.0MotifMicrobody targeting signal

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneEPHX2chr8:27646495chr8:27394301ENST000003804761119259_531337503.0DomainAB hydrolase-1
TgeneEPHX2chr8:27646495chr8:27394301ENST000005214001119259_531390556.0DomainAB hydrolase-1
TgeneEPHX2chr8:27646495chr8:27394301ENST000005217801018259_531324490.0DomainAB hydrolase-1
TgeneEPHX2chr8:27646495chr8:27394301ENST000003804761119123_124337503.0RegionPhosphate binding
TgeneEPHX2chr8:27646495chr8:27394301ENST0000038047611191_224337503.0RegionNote=Phosphatase
TgeneEPHX2chr8:27646495chr8:27394301ENST000003804761119235_555337503.0RegionNote=Epoxide hydrolase
TgeneEPHX2chr8:27646495chr8:27394301ENST000005214001119123_124390556.0RegionPhosphate binding
TgeneEPHX2chr8:27646495chr8:27394301ENST0000052140011191_224390556.0RegionNote=Phosphatase
TgeneEPHX2chr8:27646495chr8:27394301ENST000005214001119235_555390556.0RegionNote=Epoxide hydrolase
TgeneEPHX2chr8:27646495chr8:27394301ENST000005217801018123_124324490.0RegionPhosphate binding
TgeneEPHX2chr8:27646495chr8:27394301ENST0000052178010181_224324490.0RegionNote=Phosphatase
TgeneEPHX2chr8:27646495chr8:27394301ENST000005217801018235_555324490.0RegionNote=Epoxide hydrolase


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Fusion Gene Sequence for ESCO2-EPHX2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>27516_27516_1_ESCO2-EPHX2_ESCO2_chr8_27646495_ENST00000305188_EPHX2_chr8_27394301_ENST00000380476_length(transcript)=2390nt_BP=1501nt
AGATTTTTCACCTCACCAGGGCGCGAGAATCTTGGAAACAGCCACCAGGGTGGGCGGGGCAAGGGCTGGTGCTCCACCAATCACCGAGCC
AGCCCCTGGAAGCGCTGAGCCGTGGCCAATCGGAACGCAGCGGCTTCCTCCTAGCCTGGCGCGCGATTATTTGAAGACGCTCACGGAGCG
GCTGGCTAGGCTGAGGAGAGCTCGCCGGGCTCTGAGGCGCAGGAATTCAATAAAGAAAATGGCAGCTCTTACTCCAAGGAAGAGGAAGCA
GGATTCTTTGAAGTGTGACAGCCTTTTACACTTCACTGAAAATCTGTTTCCATCACCTAATAAAAAGCACTGTTTTTATCAAAACAGTGA
TAAAAATGAAGAAAACCTGCATTGCTCTCAACAAGAGCATTTTGTTTTAAGTGCGCTCAAAACAACTGAAATAAATAGACTGCCATCAGC
AAATCAAGGCTCACCATTTAAATCTGCGCTCTCCACTGTATCTTTTTACAACCAAAATAAGTGGTACCTCAATCCACTGGAGAGAAAGCT
GATAAAAGAGAGTAGATCTACTTGTCTAAAAACTAATGATGAAGATAAATCTTTTCCCATTGTGACAGAAAAAATGCAAGGAAAACCAGT
CTGCTCCAAGAAGAACAACAAAAAACCACAGAAGAGTTTAACTGCTAAGTATCAACCAAAGTATAGACACATCAAGCCTGTATCAAGGAA
TTCTAGAAATTCCAAGCAAAATCGAGTGATCTATAAGCCAATTGTGGAGAAGGAAAATAATTGTCATTCAGCTGAAAATAATTCCAATGC
TCCTCGGGTTCTGAGCCAAAAAATAAAACCACAAGTTACACTCCAGGGTGGAGCAGCATTTTTTGTTAGAAAAAAATCTTCTCTTAGAAA
ATCGTCCCTGGAAAATGAGCCGTCACTGGGACGCACCCAAAAGAGTAAATCAGAAGTCATTGAAGATTCTGATGTAGAGACTGTCAGTGA
AAAAAAAACTTTTGCGACAAGGCAAGTGCCAAAGTGCTTGGTCCTAGAAGAGAAATTGAAAATTGGACTACTGAGTGCAAGCAGTAAAAA
TAAAGAGAAATTAATAAAGGATTCATCAGATGACAGAGTTTCTTCAAAGGAACATAAAGTTGATAAAAATGAGGCTTTTTCTTCAGAGGA
TTCTCTTGGTGAGAATAAGACAATTTCTCCTAAGTCCACTGTCTATCCAATCTTCAGTGCATCTTCAGTCAATTCAAAAAGATCTTTAGG
TGAAGAACAGTTTTCTGTGGGATCTGTCAACTTCATGAAACAGACCAATATCCAGAAAAATACTAATACCAGAGATACAAGTAAAAAAAC
AAAAGACCAGCTCATCATCGACGCTGGTCAGAAACATTTTGGGGCTACTGTGTGCAAGTCTTGTGGTATGATATATACTGCTTCCAACCC
TGAAGATGAAATGCAGCATGTACAGCATCACCACAGGTTTCTGGAAGGAATCAAATATGTGGGAGTGGCTGAGGCTGAACTGGAACAGAA
CCTGAGTCGGACTTTCAAAAGCCTCTTCAGAGCAAGCGATGAGAGTGTTTTATCCATGCATAAAGTCTGTGAAGCGGGAGGACTTTTTGT
AAATAGCCCAGAAGAGCCCAGCCTCAGCAGGATGGTCACTGAGGAGGAAATCCAGTTCTATGTGCAGCAGTTCAAGAAGTCTGGTTTCAG
AGGTCCTCTAAACTGGTACCGAAACATGGAAAGGAACTGGAAGTGGGCTTGCAAAAGCTTGGGACGGAAGATCCTGATTCCGGCCCTGAT
GGTCACGGCGGAGAAGGACTTCGTGCTCGTTCCTCAGATGTCCCAGCACATGGAGGACTGGATTCCCCACCTGAAAAGGGGACACATTGA
GGACTGTGGGCACTGGACACAGATGGACAAGCCAACCGAGGTGAATCAGATCCTCATTAAGTGGCTGGATTCTGATGCCCGGAACCCACC
GGTGGTCTCAAAGATGTAGAACGCAGCGTGTGCCCACGCTCAGCAGGTGTGCCATCCTTCCACCTGCTGGGGCACCATTCTTAGTATACA
GAGGTGGCCTTACACACATCTTGCATGGATGGCAGCATTGTTCTGAAGGGGTTTGCAGAAAAAAAAGATTTTCTTTACATAAAGTGAATC
AAATTTGACATTATTTTAGATCCCAGAGAAATCAGGTGTGATTAGTTCTCCAGGCATGAATGCATCGTCCCTTTATCTGTAAGAACCCTT
AGTGTCCTGTAGGGGGACAGAATGGGGTGGCCAGGTGGTGATTTCTCTTTGACCAATGCATAGTTTGGCAGAAAAATCAGCCGTTCATTT

>27516_27516_1_ESCO2-EPHX2_ESCO2_chr8_27646495_ENST00000305188_EPHX2_chr8_27394301_ENST00000380476_length(amino acids)=655AA_BP=490
METATRVGGARAGAPPITEPAPGSAEPWPIGTQRLPPSLARDYLKTLTERLARLRRARRALRRRNSIKKMAALTPRKRKQDSLKCDSLLH
FTENLFPSPNKKHCFYQNSDKNEENLHCSQQEHFVLSALKTTEINRLPSANQGSPFKSALSTVSFYNQNKWYLNPLERKLIKESRSTCLK
TNDEDKSFPIVTEKMQGKPVCSKKNNKKPQKSLTAKYQPKYRHIKPVSRNSRNSKQNRVIYKPIVEKENNCHSAENNSNAPRVLSQKIKP
QVTLQGGAAFFVRKKSSLRKSSLENEPSLGRTQKSKSEVIEDSDVETVSEKKTFATRQVPKCLVLEEKLKIGLLSASSKNKEKLIKDSSD
DRVSSKEHKVDKNEAFSSEDSLGENKTISPKSTVYPIFSASSVNSKRSLGEEQFSVGSVNFMKQTNIQKNTNTRDTSKKTKDQLIIDAGQ
KHFGATVCKSCGMIYTASNPEDEMQHVQHHHRFLEGIKYVGVAEAELEQNLSRTFKSLFRASDESVLSMHKVCEAGGLFVNSPEEPSLSR
MVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDK

--------------------------------------------------------------
>27516_27516_2_ESCO2-EPHX2_ESCO2_chr8_27646495_ENST00000305188_EPHX2_chr8_27394301_ENST00000517536_length(transcript)=2396nt_BP=1501nt
AGATTTTTCACCTCACCAGGGCGCGAGAATCTTGGAAACAGCCACCAGGGTGGGCGGGGCAAGGGCTGGTGCTCCACCAATCACCGAGCC
AGCCCCTGGAAGCGCTGAGCCGTGGCCAATCGGAACGCAGCGGCTTCCTCCTAGCCTGGCGCGCGATTATTTGAAGACGCTCACGGAGCG
GCTGGCTAGGCTGAGGAGAGCTCGCCGGGCTCTGAGGCGCAGGAATTCAATAAAGAAAATGGCAGCTCTTACTCCAAGGAAGAGGAAGCA
GGATTCTTTGAAGTGTGACAGCCTTTTACACTTCACTGAAAATCTGTTTCCATCACCTAATAAAAAGCACTGTTTTTATCAAAACAGTGA
TAAAAATGAAGAAAACCTGCATTGCTCTCAACAAGAGCATTTTGTTTTAAGTGCGCTCAAAACAACTGAAATAAATAGACTGCCATCAGC
AAATCAAGGCTCACCATTTAAATCTGCGCTCTCCACTGTATCTTTTTACAACCAAAATAAGTGGTACCTCAATCCACTGGAGAGAAAGCT
GATAAAAGAGAGTAGATCTACTTGTCTAAAAACTAATGATGAAGATAAATCTTTTCCCATTGTGACAGAAAAAATGCAAGGAAAACCAGT
CTGCTCCAAGAAGAACAACAAAAAACCACAGAAGAGTTTAACTGCTAAGTATCAACCAAAGTATAGACACATCAAGCCTGTATCAAGGAA
TTCTAGAAATTCCAAGCAAAATCGAGTGATCTATAAGCCAATTGTGGAGAAGGAAAATAATTGTCATTCAGCTGAAAATAATTCCAATGC
TCCTCGGGTTCTGAGCCAAAAAATAAAACCACAAGTTACACTCCAGGGTGGAGCAGCATTTTTTGTTAGAAAAAAATCTTCTCTTAGAAA
ATCGTCCCTGGAAAATGAGCCGTCACTGGGACGCACCCAAAAGAGTAAATCAGAAGTCATTGAAGATTCTGATGTAGAGACTGTCAGTGA
AAAAAAAACTTTTGCGACAAGGCAAGTGCCAAAGTGCTTGGTCCTAGAAGAGAAATTGAAAATTGGACTACTGAGTGCAAGCAGTAAAAA
TAAAGAGAAATTAATAAAGGATTCATCAGATGACAGAGTTTCTTCAAAGGAACATAAAGTTGATAAAAATGAGGCTTTTTCTTCAGAGGA
TTCTCTTGGTGAGAATAAGACAATTTCTCCTAAGTCCACTGTCTATCCAATCTTCAGTGCATCTTCAGTCAATTCAAAAAGATCTTTAGG
TGAAGAACAGTTTTCTGTGGGATCTGTCAACTTCATGAAACAGACCAATATCCAGAAAAATACTAATACCAGAGATACAAGTAAAAAAAC
AAAAGACCAGCTCATCATCGACGCTGGTCAGAAACATTTTGGGGCTACTGTGTGCAAGTCTTGTGGTATGATATATACTGCTTCCAACCC
TGAAGATGAAATGCAGCATGTACAGCATCACCACAGGTTTCTGGAAGGAATCAAATATGTGGGAGTGGCTGAGGCTGAACTGGAACAGAA
CCTGAGTCGGACTTTCAAAAGCCTCTTCAGAGCAAGCGATGAGAGTGTTTTATCCATGCATAAAGTCTGTGAAGCGGGAGGACTTTTTGT
AAATAGCCCAGAAGAGCCCAGCCTCAGCAGGATGGTCACTGAGGAGGAAATCCAGTTCTATGTGCAGCAGTTCAAGAAGTCTGGTTTCAG
AGGTCCTCTAAACTGGTACCGAAACATGGAAAGGAACTGGAAGTGGGCTTGCAAAAGCTTGGGACGGAAGATCCTGATTCCGGCCCTGAT
GGTCACGGCGGAGAAGGACTTCGTGCTCGTTCCTCAGATGTCCCAGCACATGGAGGACTGGATTCCCCACCTGAAAAGGGGACACATTGA
GGACTGTGGGCACTGGACACAGATGGACAAGCCAACCGAGGTGAATCAGATCCTCATTAAGTGGCTGGATTCTGATGCCCGGAACCCACC
GGTGGTCTCAAAGATGTAGAACGCAGCGTGTGCCCACGCTCAGCAGGTGTGCCATCCTTCCACCTGCTGGGGCACCATTCTTAGTATACA
GAGGTGGCCTTACACACATCTTGCATGGATGGCAGCATTGTTCTGAAGGGGTTTGCAGAAAAAAAAGATTTTCTTTACATAAAGTGAATC
AAATTTGACATTATTTTAGATCCCAGAGAAATCAGGTGTGATTAGTTCTCCAGGCATGAATGCATCGTCCCTTTATCTGTAAGAACCCTT
AGTGTCCTGTAGGGGGACAGAATGGGGTGGCCAGGTGGTGATTTCTCTTTGACCAATGCATAGTTTGGCAGAAAAATCAGCCGTTCATTT

>27516_27516_2_ESCO2-EPHX2_ESCO2_chr8_27646495_ENST00000305188_EPHX2_chr8_27394301_ENST00000517536_length(amino acids)=655AA_BP=490
METATRVGGARAGAPPITEPAPGSAEPWPIGTQRLPPSLARDYLKTLTERLARLRRARRALRRRNSIKKMAALTPRKRKQDSLKCDSLLH
FTENLFPSPNKKHCFYQNSDKNEENLHCSQQEHFVLSALKTTEINRLPSANQGSPFKSALSTVSFYNQNKWYLNPLERKLIKESRSTCLK
TNDEDKSFPIVTEKMQGKPVCSKKNNKKPQKSLTAKYQPKYRHIKPVSRNSRNSKQNRVIYKPIVEKENNCHSAENNSNAPRVLSQKIKP
QVTLQGGAAFFVRKKSSLRKSSLENEPSLGRTQKSKSEVIEDSDVETVSEKKTFATRQVPKCLVLEEKLKIGLLSASSKNKEKLIKDSSD
DRVSSKEHKVDKNEAFSSEDSLGENKTISPKSTVYPIFSASSVNSKRSLGEEQFSVGSVNFMKQTNIQKNTNTRDTSKKTKDQLIIDAGQ
KHFGATVCKSCGMIYTASNPEDEMQHVQHHHRFLEGIKYVGVAEAELEQNLSRTFKSLFRASDESVLSMHKVCEAGGLFVNSPEEPSLSR
MVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDK

--------------------------------------------------------------
>27516_27516_3_ESCO2-EPHX2_ESCO2_chr8_27646495_ENST00000305188_EPHX2_chr8_27394301_ENST00000518379_length(transcript)=2369nt_BP=1501nt
AGATTTTTCACCTCACCAGGGCGCGAGAATCTTGGAAACAGCCACCAGGGTGGGCGGGGCAAGGGCTGGTGCTCCACCAATCACCGAGCC
AGCCCCTGGAAGCGCTGAGCCGTGGCCAATCGGAACGCAGCGGCTTCCTCCTAGCCTGGCGCGCGATTATTTGAAGACGCTCACGGAGCG
GCTGGCTAGGCTGAGGAGAGCTCGCCGGGCTCTGAGGCGCAGGAATTCAATAAAGAAAATGGCAGCTCTTACTCCAAGGAAGAGGAAGCA
GGATTCTTTGAAGTGTGACAGCCTTTTACACTTCACTGAAAATCTGTTTCCATCACCTAATAAAAAGCACTGTTTTTATCAAAACAGTGA
TAAAAATGAAGAAAACCTGCATTGCTCTCAACAAGAGCATTTTGTTTTAAGTGCGCTCAAAACAACTGAAATAAATAGACTGCCATCAGC
AAATCAAGGCTCACCATTTAAATCTGCGCTCTCCACTGTATCTTTTTACAACCAAAATAAGTGGTACCTCAATCCACTGGAGAGAAAGCT
GATAAAAGAGAGTAGATCTACTTGTCTAAAAACTAATGATGAAGATAAATCTTTTCCCATTGTGACAGAAAAAATGCAAGGAAAACCAGT
CTGCTCCAAGAAGAACAACAAAAAACCACAGAAGAGTTTAACTGCTAAGTATCAACCAAAGTATAGACACATCAAGCCTGTATCAAGGAA
TTCTAGAAATTCCAAGCAAAATCGAGTGATCTATAAGCCAATTGTGGAGAAGGAAAATAATTGTCATTCAGCTGAAAATAATTCCAATGC
TCCTCGGGTTCTGAGCCAAAAAATAAAACCACAAGTTACACTCCAGGGTGGAGCAGCATTTTTTGTTAGAAAAAAATCTTCTCTTAGAAA
ATCGTCCCTGGAAAATGAGCCGTCACTGGGACGCACCCAAAAGAGTAAATCAGAAGTCATTGAAGATTCTGATGTAGAGACTGTCAGTGA
AAAAAAAACTTTTGCGACAAGGCAAGTGCCAAAGTGCTTGGTCCTAGAAGAGAAATTGAAAATTGGACTACTGAGTGCAAGCAGTAAAAA
TAAAGAGAAATTAATAAAGGATTCATCAGATGACAGAGTTTCTTCAAAGGAACATAAAGTTGATAAAAATGAGGCTTTTTCTTCAGAGGA
TTCTCTTGGTGAGAATAAGACAATTTCTCCTAAGTCCACTGTCTATCCAATCTTCAGTGCATCTTCAGTCAATTCAAAAAGATCTTTAGG
TGAAGAACAGTTTTCTGTGGGATCTGTCAACTTCATGAAACAGACCAATATCCAGAAAAATACTAATACCAGAGATACAAGTAAAAAAAC
AAAAGACCAGCTCATCATCGACGCTGGTCAGAAACATTTTGGGGCTACTGTGTGCAAGTCTTGTGGTATGATATATACTGCTTCCAACCC
TGAAGATGAAATGCAGCATGTACAGCATCACCACAGGTTTCTGGAAGGAATCAAATATGTGGGAGTGGCTGAGGCTGAACTGGAACAGAA
CCTGAGTCGGACTTTCAAAAGCCTCTTCAGAGCAAGCGATGAGAGTGTTTTATCCATGCATAAAGTCTGTGAAGCGGGAGGACTTTTTGT
AAATAGCCCAGAAGAGCCCAGCCTCAGCAGGATGGTCACTGAGGAGGAAATCCAGTTCTATGTGCAGCAGTTCAAGAAGTCTGGTTTCAG
AGGTCCTCTAAACTGGTACCGAAACATGGAAAGGAACTGGAAGTGGGCTTGCAAAAGCTTGGGACGGAAGATCCTGATTCCGGCCCTGAT
GGTCACGGCGGAGAAGGACTTCGTGCTCGTTCCTCAGATGTCCCAGCACATGGAGGACTGGATTCCCCACCTGAAAAGGGGACACATTGA
GGACTGTGGGCACTGGACACAGATGGACAAGCCAACCGAGGTGAATCAGATCCTCATTAAGTGGCTGGATTCTGATGCCCGGAACCCACC
GGTGGTCTCAAAGATGTAGAACGCAGCGTGTGCCCACGCTCAGCAGGTGTGCCATCCTTCCACCTGCTGGGGCACCATTCTTAGTATACA
GAGGTGGCCTTACACACATCTTGCATGGATGGCAGCATTGTTCTGAAGGGGTTTGCAGAAAAAAAAGATTTTCTTTACATAAAGTGAATC
AAATTTGACATTATTTTAGATCCCAGAGAAATCAGGTGTGATTAGTTCTCCAGGCATGAATGCATCGTCCCTTTATCTGTAAGAACCCTT
AGTGTCCTGTAGGGGGACAGAATGGGGTGGCCAGGTGGTGATTTCTCTTTGACCAATGCATAGTTTGGCAGAAAAATCAGCCGTTCATTT

>27516_27516_3_ESCO2-EPHX2_ESCO2_chr8_27646495_ENST00000305188_EPHX2_chr8_27394301_ENST00000518379_length(amino acids)=655AA_BP=490
METATRVGGARAGAPPITEPAPGSAEPWPIGTQRLPPSLARDYLKTLTERLARLRRARRALRRRNSIKKMAALTPRKRKQDSLKCDSLLH
FTENLFPSPNKKHCFYQNSDKNEENLHCSQQEHFVLSALKTTEINRLPSANQGSPFKSALSTVSFYNQNKWYLNPLERKLIKESRSTCLK
TNDEDKSFPIVTEKMQGKPVCSKKNNKKPQKSLTAKYQPKYRHIKPVSRNSRNSKQNRVIYKPIVEKENNCHSAENNSNAPRVLSQKIKP
QVTLQGGAAFFVRKKSSLRKSSLENEPSLGRTQKSKSEVIEDSDVETVSEKKTFATRQVPKCLVLEEKLKIGLLSASSKNKEKLIKDSSD
DRVSSKEHKVDKNEAFSSEDSLGENKTISPKSTVYPIFSASSVNSKRSLGEEQFSVGSVNFMKQTNIQKNTNTRDTSKKTKDQLIIDAGQ
KHFGATVCKSCGMIYTASNPEDEMQHVQHHHRFLEGIKYVGVAEAELEQNLSRTFKSLFRASDESVLSMHKVCEAGGLFVNSPEEPSLSR
MVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDK

--------------------------------------------------------------
>27516_27516_4_ESCO2-EPHX2_ESCO2_chr8_27646495_ENST00000305188_EPHX2_chr8_27394301_ENST00000521400_length(transcript)=3041nt_BP=1501nt
AGATTTTTCACCTCACCAGGGCGCGAGAATCTTGGAAACAGCCACCAGGGTGGGCGGGGCAAGGGCTGGTGCTCCACCAATCACCGAGCC
AGCCCCTGGAAGCGCTGAGCCGTGGCCAATCGGAACGCAGCGGCTTCCTCCTAGCCTGGCGCGCGATTATTTGAAGACGCTCACGGAGCG
GCTGGCTAGGCTGAGGAGAGCTCGCCGGGCTCTGAGGCGCAGGAATTCAATAAAGAAAATGGCAGCTCTTACTCCAAGGAAGAGGAAGCA
GGATTCTTTGAAGTGTGACAGCCTTTTACACTTCACTGAAAATCTGTTTCCATCACCTAATAAAAAGCACTGTTTTTATCAAAACAGTGA
TAAAAATGAAGAAAACCTGCATTGCTCTCAACAAGAGCATTTTGTTTTAAGTGCGCTCAAAACAACTGAAATAAATAGACTGCCATCAGC
AAATCAAGGCTCACCATTTAAATCTGCGCTCTCCACTGTATCTTTTTACAACCAAAATAAGTGGTACCTCAATCCACTGGAGAGAAAGCT
GATAAAAGAGAGTAGATCTACTTGTCTAAAAACTAATGATGAAGATAAATCTTTTCCCATTGTGACAGAAAAAATGCAAGGAAAACCAGT
CTGCTCCAAGAAGAACAACAAAAAACCACAGAAGAGTTTAACTGCTAAGTATCAACCAAAGTATAGACACATCAAGCCTGTATCAAGGAA
TTCTAGAAATTCCAAGCAAAATCGAGTGATCTATAAGCCAATTGTGGAGAAGGAAAATAATTGTCATTCAGCTGAAAATAATTCCAATGC
TCCTCGGGTTCTGAGCCAAAAAATAAAACCACAAGTTACACTCCAGGGTGGAGCAGCATTTTTTGTTAGAAAAAAATCTTCTCTTAGAAA
ATCGTCCCTGGAAAATGAGCCGTCACTGGGACGCACCCAAAAGAGTAAATCAGAAGTCATTGAAGATTCTGATGTAGAGACTGTCAGTGA
AAAAAAAACTTTTGCGACAAGGCAAGTGCCAAAGTGCTTGGTCCTAGAAGAGAAATTGAAAATTGGACTACTGAGTGCAAGCAGTAAAAA
TAAAGAGAAATTAATAAAGGATTCATCAGATGACAGAGTTTCTTCAAAGGAACATAAAGTTGATAAAAATGAGGCTTTTTCTTCAGAGGA
TTCTCTTGGTGAGAATAAGACAATTTCTCCTAAGTCCACTGTCTATCCAATCTTCAGTGCATCTTCAGTCAATTCAAAAAGATCTTTAGG
TGAAGAACAGTTTTCTGTGGGATCTGTCAACTTCATGAAACAGACCAATATCCAGAAAAATACTAATACCAGAGATACAAGTAAAAAAAC
AAAAGACCAGCTCATCATCGACGCTGGTCAGAAACATTTTGGGGCTACTGTGTGCAAGTCTTGTGGTATGATATATACTGCTTCCAACCC
TGAAGATGAAATGCAGCATGTACAGCATCACCACAGGTTTCTGGAAGGAATCAAATATGTGGGAGTGGCTGAGGCTGAACTGGAACAGAA
CCTGAGTCGGACTTTCAAAAGCCTCTTCAGAGCAAGCGATGAGAGTGTTTTATCCATGCATAAAGTCTGTGAAGCGGGAGGACTTTTTGT
AAATAGCCCAGAAGAGCCCAGCCTCAGCAGGATGGTCACTGAGGAGGAAATCCAGTTCTATGTGCAGCAGTTCAAGAAGTCTGGTTTCAG
AGGTCCTCTAAACTGGTACCGAAACATGGAAAGGAACTGGAAGTGGGCTTGCAAAAGCTTGGGACGGAAGATCCTGATTCCGGCCCTGAT
GGTCACGGCGGAGAAGGACTTCGTGCTCGTTCCTCAGATGTCCCAGCACATGGAGGACTGGATTCCCCACCTGAAAAGGGGACACATTGA
GGACTGTGGGCACTGGACACAGATGGACAAGCCAACCGAGGTGAATCAGATCCTCATTAAGTGGCTGGATTCTGATGCCCGGAACCCACC
GGTGGTCTCAAAGATGTAGAACGCAGCGTGTGCCCACGCTCAGCAGGTGTGCCATCCTTCCACCTGCTGGGGCACCATTCTTAGTATACA
GAGGTGGCCTTACACACATCTTGCATGGATGGCAGCATTGTTCTGAAGGGGTTTGCAGAAAAAAAAGATTTTCTTTACATAAAGTGAATC
AAATTTGACATTATTTTAGATCCCAGAGAAATCAGGTGTGATTAGTTCTCCAGGCATGAATGCATCGTCCCTTTATCTGTAAGAACCCTT
AGTGTCCTGTAGGGGGACAGAATGGGGTGGCCAGGTGGTGATTTCTCTTTGACCAATGCATAGTTTGGCAGAAAAATCAGCCGTTCATTT
AGAAGAATCTTAGCAGAGATTGGGATGCCTTACTCAATAAAGCTAAGATGACTATGCTGCTGGCTGTCTTTGTTCTTGGAGAGGTGGAGT
GACTGTTCACGGAGAATGCACGGCATGGGGATGAACCCTTTCCCTCTGCTTTTGAGCCCTGTTCTGGGCTCCAAGGTGCTGTATGATCTA
GGCCGTGCTGGCCAGGAGACAATCCTATGGGGATGGCAGTGGTGTCTTGTGCTCTGTCCCCTAGAGCAGTCACTGGCCACAGGTAGCCAC
CTGCCTTTCTCCCGGCTTCCCTAGCAGAGTTTGCTCAGGCACAAATGTGCACCTGGAGCATTTGAAATGTGCTAGTGAGGCTGAGGAAGA
GAATTTTAAATTTCATTGAATTGTAATCAGTTTAAAGTTAAATAGCAGCAGCTGCCATGAGGCTCAGGCAGATCCAGCTCATCTTCCCCT
CTGCCCCCTCCTCCCTATCTTCCCCTCTACCCTCTCCTGCCTCCTGTCACATCCGGTTAGGCTCCCATCTCACTGATGTGTCTCCTGCAG
TGGTCTCTCCCCTGCCCTGCTTCCAGCCCCAGAGTCCTGGAGCAGCAGCCTCCTCACGGGTCTTGCCGCCCACATGGTTGGATCCTGAAA

>27516_27516_4_ESCO2-EPHX2_ESCO2_chr8_27646495_ENST00000305188_EPHX2_chr8_27394301_ENST00000521400_length(amino acids)=655AA_BP=490
METATRVGGARAGAPPITEPAPGSAEPWPIGTQRLPPSLARDYLKTLTERLARLRRARRALRRRNSIKKMAALTPRKRKQDSLKCDSLLH
FTENLFPSPNKKHCFYQNSDKNEENLHCSQQEHFVLSALKTTEINRLPSANQGSPFKSALSTVSFYNQNKWYLNPLERKLIKESRSTCLK
TNDEDKSFPIVTEKMQGKPVCSKKNNKKPQKSLTAKYQPKYRHIKPVSRNSRNSKQNRVIYKPIVEKENNCHSAENNSNAPRVLSQKIKP
QVTLQGGAAFFVRKKSSLRKSSLENEPSLGRTQKSKSEVIEDSDVETVSEKKTFATRQVPKCLVLEEKLKIGLLSASSKNKEKLIKDSSD
DRVSSKEHKVDKNEAFSSEDSLGENKTISPKSTVYPIFSASSVNSKRSLGEEQFSVGSVNFMKQTNIQKNTNTRDTSKKTKDQLIIDAGQ
KHFGATVCKSCGMIYTASNPEDEMQHVQHHHRFLEGIKYVGVAEAELEQNLSRTFKSLFRASDESVLSMHKVCEAGGLFVNSPEEPSLSR
MVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDK

--------------------------------------------------------------
>27516_27516_5_ESCO2-EPHX2_ESCO2_chr8_27646495_ENST00000305188_EPHX2_chr8_27394301_ENST00000521780_length(transcript)=2396nt_BP=1501nt
AGATTTTTCACCTCACCAGGGCGCGAGAATCTTGGAAACAGCCACCAGGGTGGGCGGGGCAAGGGCTGGTGCTCCACCAATCACCGAGCC
AGCCCCTGGAAGCGCTGAGCCGTGGCCAATCGGAACGCAGCGGCTTCCTCCTAGCCTGGCGCGCGATTATTTGAAGACGCTCACGGAGCG
GCTGGCTAGGCTGAGGAGAGCTCGCCGGGCTCTGAGGCGCAGGAATTCAATAAAGAAAATGGCAGCTCTTACTCCAAGGAAGAGGAAGCA
GGATTCTTTGAAGTGTGACAGCCTTTTACACTTCACTGAAAATCTGTTTCCATCACCTAATAAAAAGCACTGTTTTTATCAAAACAGTGA
TAAAAATGAAGAAAACCTGCATTGCTCTCAACAAGAGCATTTTGTTTTAAGTGCGCTCAAAACAACTGAAATAAATAGACTGCCATCAGC
AAATCAAGGCTCACCATTTAAATCTGCGCTCTCCACTGTATCTTTTTACAACCAAAATAAGTGGTACCTCAATCCACTGGAGAGAAAGCT
GATAAAAGAGAGTAGATCTACTTGTCTAAAAACTAATGATGAAGATAAATCTTTTCCCATTGTGACAGAAAAAATGCAAGGAAAACCAGT
CTGCTCCAAGAAGAACAACAAAAAACCACAGAAGAGTTTAACTGCTAAGTATCAACCAAAGTATAGACACATCAAGCCTGTATCAAGGAA
TTCTAGAAATTCCAAGCAAAATCGAGTGATCTATAAGCCAATTGTGGAGAAGGAAAATAATTGTCATTCAGCTGAAAATAATTCCAATGC
TCCTCGGGTTCTGAGCCAAAAAATAAAACCACAAGTTACACTCCAGGGTGGAGCAGCATTTTTTGTTAGAAAAAAATCTTCTCTTAGAAA
ATCGTCCCTGGAAAATGAGCCGTCACTGGGACGCACCCAAAAGAGTAAATCAGAAGTCATTGAAGATTCTGATGTAGAGACTGTCAGTGA
AAAAAAAACTTTTGCGACAAGGCAAGTGCCAAAGTGCTTGGTCCTAGAAGAGAAATTGAAAATTGGACTACTGAGTGCAAGCAGTAAAAA
TAAAGAGAAATTAATAAAGGATTCATCAGATGACAGAGTTTCTTCAAAGGAACATAAAGTTGATAAAAATGAGGCTTTTTCTTCAGAGGA
TTCTCTTGGTGAGAATAAGACAATTTCTCCTAAGTCCACTGTCTATCCAATCTTCAGTGCATCTTCAGTCAATTCAAAAAGATCTTTAGG
TGAAGAACAGTTTTCTGTGGGATCTGTCAACTTCATGAAACAGACCAATATCCAGAAAAATACTAATACCAGAGATACAAGTAAAAAAAC
AAAAGACCAGCTCATCATCGACGCTGGTCAGAAACATTTTGGGGCTACTGTGTGCAAGTCTTGTGGTATGATATATACTGCTTCCAACCC
TGAAGATGAAATGCAGCATGTACAGCATCACCACAGGTTTCTGGAAGGAATCAAATATGTGGGAGTGGCTGAGGCTGAACTGGAACAGAA
CCTGAGTCGGACTTTCAAAAGCCTCTTCAGAGCAAGCGATGAGAGTGTTTTATCCATGCATAAAGTCTGTGAAGCGGGAGGACTTTTTGT
AAATAGCCCAGAAGAGCCCAGCCTCAGCAGGATGGTCACTGAGGAGGAAATCCAGTTCTATGTGCAGCAGTTCAAGAAGTCTGGTTTCAG
AGGTCCTCTAAACTGGTACCGAAACATGGAAAGGAACTGGAAGTGGGCTTGCAAAAGCTTGGGACGGAAGATCCTGATTCCGGCCCTGAT
GGTCACGGCGGAGAAGGACTTCGTGCTCGTTCCTCAGATGTCCCAGCACATGGAGGACTGGATTCCCCACCTGAAAAGGGGACACATTGA
GGACTGTGGGCACTGGACACAGATGGACAAGCCAACCGAGGTGAATCAGATCCTCATTAAGTGGCTGGATTCTGATGCCCGGAACCCACC
GGTGGTCTCAAAGATGTAGAACGCAGCGTGTGCCCACGCTCAGCAGGTGTGCCATCCTTCCACCTGCTGGGGCACCATTCTTAGTATACA
GAGGTGGCCTTACACACATCTTGCATGGATGGCAGCATTGTTCTGAAGGGGTTTGCAGAAAAAAAAGATTTTCTTTACATAAAGTGAATC
AAATTTGACATTATTTTAGATCCCAGAGAAATCAGGTGTGATTAGTTCTCCAGGCATGAATGCATCGTCCCTTTATCTGTAAGAACCCTT
AGTGTCCTGTAGGGGGACAGAATGGGGTGGCCAGGTGGTGATTTCTCTTTGACCAATGCATAGTTTGGCAGAAAAATCAGCCGTTCATTT

>27516_27516_5_ESCO2-EPHX2_ESCO2_chr8_27646495_ENST00000305188_EPHX2_chr8_27394301_ENST00000521780_length(amino acids)=655AA_BP=490
METATRVGGARAGAPPITEPAPGSAEPWPIGTQRLPPSLARDYLKTLTERLARLRRARRALRRRNSIKKMAALTPRKRKQDSLKCDSLLH
FTENLFPSPNKKHCFYQNSDKNEENLHCSQQEHFVLSALKTTEINRLPSANQGSPFKSALSTVSFYNQNKWYLNPLERKLIKESRSTCLK
TNDEDKSFPIVTEKMQGKPVCSKKNNKKPQKSLTAKYQPKYRHIKPVSRNSRNSKQNRVIYKPIVEKENNCHSAENNSNAPRVLSQKIKP
QVTLQGGAAFFVRKKSSLRKSSLENEPSLGRTQKSKSEVIEDSDVETVSEKKTFATRQVPKCLVLEEKLKIGLLSASSKNKEKLIKDSSD
DRVSSKEHKVDKNEAFSSEDSLGENKTISPKSTVYPIFSASSVNSKRSLGEEQFSVGSVNFMKQTNIQKNTNTRDTSKKTKDQLIIDAGQ
KHFGATVCKSCGMIYTASNPEDEMQHVQHHHRFLEGIKYVGVAEAELEQNLSRTFKSLFRASDESVLSMHKVCEAGGLFVNSPEEPSLSR
MVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDK

--------------------------------------------------------------
>27516_27516_6_ESCO2-EPHX2_ESCO2_chr8_27646495_ENST00000397418_EPHX2_chr8_27394301_ENST00000380476_length(transcript)=2070nt_BP=1181nt
GCTCACGGAGCGGCTGGCTAGGCTGAGGAGAGCTCGCCGGGCTCTGAGGCGCAGGAATTCAATAAAGAAAATGGCAGCTCTTACTCCAAG
GAAGAGGAAGCAGGATTCTTTGAAGTGTGACAGCCTTTTACACTTCACTGAAAATCTGTTTCCATCACCTAATAAAAAGCACTGTTTTTA
TCAAAACAGTGATAAAAATGAAGAAAACCTGCATTGCTCTCAACAAGAGCATTTTGTTTTAAGTGCGCTCAAAACAACTGAAATAAATAG
ACTGCCATCAGCAAATCAAGGCTCACCATTTAAATCTGCGCTCTCCACTGTATCTTTTTACAACCAAAATAAGTGGTACCTCAATCCACT
GGAGAGAAAGCTGATAAAAGAGAGTAGATCTACTTGTCTAAAAACTAATGATGAAGATAAATCTTTTCCCATTGTGACAGAAAAAATGCA
AGGAAAACCAGTCTGCTCCAAGAAGAACAACAAAAAACCACAGAAGAGTTTAACTGCTAAGTATCAACCAAAGTATAGACACATCAAGCC
TGTATCAAGGAATTCTAGAAATTCCAAGCAAAATCGAGTGATCTATAAGCCAATTGTGGAGAAGGAAAATAATTGTCATTCAGCTGAAAA
TAATTCCAATGCTCCTCGGGTTCTGAGCCAAAAAATAAAACCACAAGTTACACTCCAGGGTGGAGCAGCATTTTTTGTTAGAAAAAAATC
TTCTCTTAGAAAATCGTCCCTGGAAAATGAGCCGTCACTGGGACGCACCCAAAAGAGTAAATCAGAAGTCATTGAAGATTCTGATGTAGA
GACTGTCAGTGAAAAAAAAACTTTTGCGACAAGGCAAGTGCCAAAGTGCTTGGTCCTAGAAGAGAAATTGAAAATTGGACTACTGAGTGC
AAGCAGTAAAAATAAAGAGAAATTAATAAAGATCTTTAGGTGAAGAACAGTTTTCTGTGGGATCTGTCAACTTCATGAAACAGACCAATA
TCCAGAAAAATACTAATACCAGAGATACAAGTAAAAAAACAAAAGACCAGCTCATCATCGACGCTGGTCAGAAACATTTTGGGGCTACTG
TGTGCAAGTCTTGTGGTATGATATATACTGCTTCCAACCCTGAAGATGAAATGCAGCATGTACAGCATCACCACAGGTTTCTGGAAGGAA
TCAAATATGTGGGAGTGGCTGAGGCTGAACTGGAACAGAACCTGAGTCGGACTTTCAAAAGCCTCTTCAGAGCAAGCGATGAGAGTGTTT
TATCCATGCATAAAGTCTGTGAAGCGGGAGGACTTTTTGTAAATAGCCCAGAAGAGCCCAGCCTCAGCAGGATGGTCACTGAGGAGGAAA
TCCAGTTCTATGTGCAGCAGTTCAAGAAGTCTGGTTTCAGAGGTCCTCTAAACTGGTACCGAAACATGGAAAGGAACTGGAAGTGGGCTT
GCAAAAGCTTGGGACGGAAGATCCTGATTCCGGCCCTGATGGTCACGGCGGAGAAGGACTTCGTGCTCGTTCCTCAGATGTCCCAGCACA
TGGAGGACTGGATTCCCCACCTGAAAAGGGGACACATTGAGGACTGTGGGCACTGGACACAGATGGACAAGCCAACCGAGGTGAATCAGA
TCCTCATTAAGTGGCTGGATTCTGATGCCCGGAACCCACCGGTGGTCTCAAAGATGTAGAACGCAGCGTGTGCCCACGCTCAGCAGGTGT
GCCATCCTTCCACCTGCTGGGGCACCATTCTTAGTATACAGAGGTGGCCTTACACACATCTTGCATGGATGGCAGCATTGTTCTGAAGGG
GTTTGCAGAAAAAAAAGATTTTCTTTACATAAAGTGAATCAAATTTGACATTATTTTAGATCCCAGAGAAATCAGGTGTGATTAGTTCTC
CAGGCATGAATGCATCGTCCCTTTATCTGTAAGAACCCTTAGTGTCCTGTAGGGGGACAGAATGGGGTGGCCAGGTGGTGATTTCTCTTT
GACCAATGCATAGTTTGGCAGAAAAATCAGCCGTTCATTTAGAAGAATCTTAGCAGAGATTGGGATGCCTTACTCAATAAAGCTAAGATG

>27516_27516_6_ESCO2-EPHX2_ESCO2_chr8_27646495_ENST00000397418_EPHX2_chr8_27394301_ENST00000380476_length(amino acids)=309AA_BP=
MARLRRARRALRRRNSIKKMAALTPRKRKQDSLKCDSLLHFTENLFPSPNKKHCFYQNSDKNEENLHCSQQEHFVLSALKTTEINRLPSA
NQGSPFKSALSTVSFYNQNKWYLNPLERKLIKESRSTCLKTNDEDKSFPIVTEKMQGKPVCSKKNNKKPQKSLTAKYQPKYRHIKPVSRN
SRNSKQNRVIYKPIVEKENNCHSAENNSNAPRVLSQKIKPQVTLQGGAAFFVRKKSSLRKSSLENEPSLGRTQKSKSEVIEDSDVETVSE

--------------------------------------------------------------
>27516_27516_7_ESCO2-EPHX2_ESCO2_chr8_27646495_ENST00000397418_EPHX2_chr8_27394301_ENST00000517536_length(transcript)=2076nt_BP=1181nt
GCTCACGGAGCGGCTGGCTAGGCTGAGGAGAGCTCGCCGGGCTCTGAGGCGCAGGAATTCAATAAAGAAAATGGCAGCTCTTACTCCAAG
GAAGAGGAAGCAGGATTCTTTGAAGTGTGACAGCCTTTTACACTTCACTGAAAATCTGTTTCCATCACCTAATAAAAAGCACTGTTTTTA
TCAAAACAGTGATAAAAATGAAGAAAACCTGCATTGCTCTCAACAAGAGCATTTTGTTTTAAGTGCGCTCAAAACAACTGAAATAAATAG
ACTGCCATCAGCAAATCAAGGCTCACCATTTAAATCTGCGCTCTCCACTGTATCTTTTTACAACCAAAATAAGTGGTACCTCAATCCACT
GGAGAGAAAGCTGATAAAAGAGAGTAGATCTACTTGTCTAAAAACTAATGATGAAGATAAATCTTTTCCCATTGTGACAGAAAAAATGCA
AGGAAAACCAGTCTGCTCCAAGAAGAACAACAAAAAACCACAGAAGAGTTTAACTGCTAAGTATCAACCAAAGTATAGACACATCAAGCC
TGTATCAAGGAATTCTAGAAATTCCAAGCAAAATCGAGTGATCTATAAGCCAATTGTGGAGAAGGAAAATAATTGTCATTCAGCTGAAAA
TAATTCCAATGCTCCTCGGGTTCTGAGCCAAAAAATAAAACCACAAGTTACACTCCAGGGTGGAGCAGCATTTTTTGTTAGAAAAAAATC
TTCTCTTAGAAAATCGTCCCTGGAAAATGAGCCGTCACTGGGACGCACCCAAAAGAGTAAATCAGAAGTCATTGAAGATTCTGATGTAGA
GACTGTCAGTGAAAAAAAAACTTTTGCGACAAGGCAAGTGCCAAAGTGCTTGGTCCTAGAAGAGAAATTGAAAATTGGACTACTGAGTGC
AAGCAGTAAAAATAAAGAGAAATTAATAAAGATCTTTAGGTGAAGAACAGTTTTCTGTGGGATCTGTCAACTTCATGAAACAGACCAATA
TCCAGAAAAATACTAATACCAGAGATACAAGTAAAAAAACAAAAGACCAGCTCATCATCGACGCTGGTCAGAAACATTTTGGGGCTACTG
TGTGCAAGTCTTGTGGTATGATATATACTGCTTCCAACCCTGAAGATGAAATGCAGCATGTACAGCATCACCACAGGTTTCTGGAAGGAA
TCAAATATGTGGGAGTGGCTGAGGCTGAACTGGAACAGAACCTGAGTCGGACTTTCAAAAGCCTCTTCAGAGCAAGCGATGAGAGTGTTT
TATCCATGCATAAAGTCTGTGAAGCGGGAGGACTTTTTGTAAATAGCCCAGAAGAGCCCAGCCTCAGCAGGATGGTCACTGAGGAGGAAA
TCCAGTTCTATGTGCAGCAGTTCAAGAAGTCTGGTTTCAGAGGTCCTCTAAACTGGTACCGAAACATGGAAAGGAACTGGAAGTGGGCTT
GCAAAAGCTTGGGACGGAAGATCCTGATTCCGGCCCTGATGGTCACGGCGGAGAAGGACTTCGTGCTCGTTCCTCAGATGTCCCAGCACA
TGGAGGACTGGATTCCCCACCTGAAAAGGGGACACATTGAGGACTGTGGGCACTGGACACAGATGGACAAGCCAACCGAGGTGAATCAGA
TCCTCATTAAGTGGCTGGATTCTGATGCCCGGAACCCACCGGTGGTCTCAAAGATGTAGAACGCAGCGTGTGCCCACGCTCAGCAGGTGT
GCCATCCTTCCACCTGCTGGGGCACCATTCTTAGTATACAGAGGTGGCCTTACACACATCTTGCATGGATGGCAGCATTGTTCTGAAGGG
GTTTGCAGAAAAAAAAGATTTTCTTTACATAAAGTGAATCAAATTTGACATTATTTTAGATCCCAGAGAAATCAGGTGTGATTAGTTCTC
CAGGCATGAATGCATCGTCCCTTTATCTGTAAGAACCCTTAGTGTCCTGTAGGGGGACAGAATGGGGTGGCCAGGTGGTGATTTCTCTTT
GACCAATGCATAGTTTGGCAGAAAAATCAGCCGTTCATTTAGAAGAATCTTAGCAGAGATTGGGATGCCTTACTCAATAAAGCTAAGATG

>27516_27516_7_ESCO2-EPHX2_ESCO2_chr8_27646495_ENST00000397418_EPHX2_chr8_27394301_ENST00000517536_length(amino acids)=309AA_BP=
MARLRRARRALRRRNSIKKMAALTPRKRKQDSLKCDSLLHFTENLFPSPNKKHCFYQNSDKNEENLHCSQQEHFVLSALKTTEINRLPSA
NQGSPFKSALSTVSFYNQNKWYLNPLERKLIKESRSTCLKTNDEDKSFPIVTEKMQGKPVCSKKNNKKPQKSLTAKYQPKYRHIKPVSRN
SRNSKQNRVIYKPIVEKENNCHSAENNSNAPRVLSQKIKPQVTLQGGAAFFVRKKSSLRKSSLENEPSLGRTQKSKSEVIEDSDVETVSE

--------------------------------------------------------------
>27516_27516_8_ESCO2-EPHX2_ESCO2_chr8_27646495_ENST00000397418_EPHX2_chr8_27394301_ENST00000518379_length(transcript)=2049nt_BP=1181nt
GCTCACGGAGCGGCTGGCTAGGCTGAGGAGAGCTCGCCGGGCTCTGAGGCGCAGGAATTCAATAAAGAAAATGGCAGCTCTTACTCCAAG
GAAGAGGAAGCAGGATTCTTTGAAGTGTGACAGCCTTTTACACTTCACTGAAAATCTGTTTCCATCACCTAATAAAAAGCACTGTTTTTA
TCAAAACAGTGATAAAAATGAAGAAAACCTGCATTGCTCTCAACAAGAGCATTTTGTTTTAAGTGCGCTCAAAACAACTGAAATAAATAG
ACTGCCATCAGCAAATCAAGGCTCACCATTTAAATCTGCGCTCTCCACTGTATCTTTTTACAACCAAAATAAGTGGTACCTCAATCCACT
GGAGAGAAAGCTGATAAAAGAGAGTAGATCTACTTGTCTAAAAACTAATGATGAAGATAAATCTTTTCCCATTGTGACAGAAAAAATGCA
AGGAAAACCAGTCTGCTCCAAGAAGAACAACAAAAAACCACAGAAGAGTTTAACTGCTAAGTATCAACCAAAGTATAGACACATCAAGCC
TGTATCAAGGAATTCTAGAAATTCCAAGCAAAATCGAGTGATCTATAAGCCAATTGTGGAGAAGGAAAATAATTGTCATTCAGCTGAAAA
TAATTCCAATGCTCCTCGGGTTCTGAGCCAAAAAATAAAACCACAAGTTACACTCCAGGGTGGAGCAGCATTTTTTGTTAGAAAAAAATC
TTCTCTTAGAAAATCGTCCCTGGAAAATGAGCCGTCACTGGGACGCACCCAAAAGAGTAAATCAGAAGTCATTGAAGATTCTGATGTAGA
GACTGTCAGTGAAAAAAAAACTTTTGCGACAAGGCAAGTGCCAAAGTGCTTGGTCCTAGAAGAGAAATTGAAAATTGGACTACTGAGTGC
AAGCAGTAAAAATAAAGAGAAATTAATAAAGATCTTTAGGTGAAGAACAGTTTTCTGTGGGATCTGTCAACTTCATGAAACAGACCAATA
TCCAGAAAAATACTAATACCAGAGATACAAGTAAAAAAACAAAAGACCAGCTCATCATCGACGCTGGTCAGAAACATTTTGGGGCTACTG
TGTGCAAGTCTTGTGGTATGATATATACTGCTTCCAACCCTGAAGATGAAATGCAGCATGTACAGCATCACCACAGGTTTCTGGAAGGAA
TCAAATATGTGGGAGTGGCTGAGGCTGAACTGGAACAGAACCTGAGTCGGACTTTCAAAAGCCTCTTCAGAGCAAGCGATGAGAGTGTTT
TATCCATGCATAAAGTCTGTGAAGCGGGAGGACTTTTTGTAAATAGCCCAGAAGAGCCCAGCCTCAGCAGGATGGTCACTGAGGAGGAAA
TCCAGTTCTATGTGCAGCAGTTCAAGAAGTCTGGTTTCAGAGGTCCTCTAAACTGGTACCGAAACATGGAAAGGAACTGGAAGTGGGCTT
GCAAAAGCTTGGGACGGAAGATCCTGATTCCGGCCCTGATGGTCACGGCGGAGAAGGACTTCGTGCTCGTTCCTCAGATGTCCCAGCACA
TGGAGGACTGGATTCCCCACCTGAAAAGGGGACACATTGAGGACTGTGGGCACTGGACACAGATGGACAAGCCAACCGAGGTGAATCAGA
TCCTCATTAAGTGGCTGGATTCTGATGCCCGGAACCCACCGGTGGTCTCAAAGATGTAGAACGCAGCGTGTGCCCACGCTCAGCAGGTGT
GCCATCCTTCCACCTGCTGGGGCACCATTCTTAGTATACAGAGGTGGCCTTACACACATCTTGCATGGATGGCAGCATTGTTCTGAAGGG
GTTTGCAGAAAAAAAAGATTTTCTTTACATAAAGTGAATCAAATTTGACATTATTTTAGATCCCAGAGAAATCAGGTGTGATTAGTTCTC
CAGGCATGAATGCATCGTCCCTTTATCTGTAAGAACCCTTAGTGTCCTGTAGGGGGACAGAATGGGGTGGCCAGGTGGTGATTTCTCTTT

>27516_27516_8_ESCO2-EPHX2_ESCO2_chr8_27646495_ENST00000397418_EPHX2_chr8_27394301_ENST00000518379_length(amino acids)=309AA_BP=
MARLRRARRALRRRNSIKKMAALTPRKRKQDSLKCDSLLHFTENLFPSPNKKHCFYQNSDKNEENLHCSQQEHFVLSALKTTEINRLPSA
NQGSPFKSALSTVSFYNQNKWYLNPLERKLIKESRSTCLKTNDEDKSFPIVTEKMQGKPVCSKKNNKKPQKSLTAKYQPKYRHIKPVSRN
SRNSKQNRVIYKPIVEKENNCHSAENNSNAPRVLSQKIKPQVTLQGGAAFFVRKKSSLRKSSLENEPSLGRTQKSKSEVIEDSDVETVSE

--------------------------------------------------------------
>27516_27516_9_ESCO2-EPHX2_ESCO2_chr8_27646495_ENST00000397418_EPHX2_chr8_27394301_ENST00000521400_length(transcript)=2721nt_BP=1181nt
GCTCACGGAGCGGCTGGCTAGGCTGAGGAGAGCTCGCCGGGCTCTGAGGCGCAGGAATTCAATAAAGAAAATGGCAGCTCTTACTCCAAG
GAAGAGGAAGCAGGATTCTTTGAAGTGTGACAGCCTTTTACACTTCACTGAAAATCTGTTTCCATCACCTAATAAAAAGCACTGTTTTTA
TCAAAACAGTGATAAAAATGAAGAAAACCTGCATTGCTCTCAACAAGAGCATTTTGTTTTAAGTGCGCTCAAAACAACTGAAATAAATAG
ACTGCCATCAGCAAATCAAGGCTCACCATTTAAATCTGCGCTCTCCACTGTATCTTTTTACAACCAAAATAAGTGGTACCTCAATCCACT
GGAGAGAAAGCTGATAAAAGAGAGTAGATCTACTTGTCTAAAAACTAATGATGAAGATAAATCTTTTCCCATTGTGACAGAAAAAATGCA
AGGAAAACCAGTCTGCTCCAAGAAGAACAACAAAAAACCACAGAAGAGTTTAACTGCTAAGTATCAACCAAAGTATAGACACATCAAGCC
TGTATCAAGGAATTCTAGAAATTCCAAGCAAAATCGAGTGATCTATAAGCCAATTGTGGAGAAGGAAAATAATTGTCATTCAGCTGAAAA
TAATTCCAATGCTCCTCGGGTTCTGAGCCAAAAAATAAAACCACAAGTTACACTCCAGGGTGGAGCAGCATTTTTTGTTAGAAAAAAATC
TTCTCTTAGAAAATCGTCCCTGGAAAATGAGCCGTCACTGGGACGCACCCAAAAGAGTAAATCAGAAGTCATTGAAGATTCTGATGTAGA
GACTGTCAGTGAAAAAAAAACTTTTGCGACAAGGCAAGTGCCAAAGTGCTTGGTCCTAGAAGAGAAATTGAAAATTGGACTACTGAGTGC
AAGCAGTAAAAATAAAGAGAAATTAATAAAGATCTTTAGGTGAAGAACAGTTTTCTGTGGGATCTGTCAACTTCATGAAACAGACCAATA
TCCAGAAAAATACTAATACCAGAGATACAAGTAAAAAAACAAAAGACCAGCTCATCATCGACGCTGGTCAGAAACATTTTGGGGCTACTG
TGTGCAAGTCTTGTGGTATGATATATACTGCTTCCAACCCTGAAGATGAAATGCAGCATGTACAGCATCACCACAGGTTTCTGGAAGGAA
TCAAATATGTGGGAGTGGCTGAGGCTGAACTGGAACAGAACCTGAGTCGGACTTTCAAAAGCCTCTTCAGAGCAAGCGATGAGAGTGTTT
TATCCATGCATAAAGTCTGTGAAGCGGGAGGACTTTTTGTAAATAGCCCAGAAGAGCCCAGCCTCAGCAGGATGGTCACTGAGGAGGAAA
TCCAGTTCTATGTGCAGCAGTTCAAGAAGTCTGGTTTCAGAGGTCCTCTAAACTGGTACCGAAACATGGAAAGGAACTGGAAGTGGGCTT
GCAAAAGCTTGGGACGGAAGATCCTGATTCCGGCCCTGATGGTCACGGCGGAGAAGGACTTCGTGCTCGTTCCTCAGATGTCCCAGCACA
TGGAGGACTGGATTCCCCACCTGAAAAGGGGACACATTGAGGACTGTGGGCACTGGACACAGATGGACAAGCCAACCGAGGTGAATCAGA
TCCTCATTAAGTGGCTGGATTCTGATGCCCGGAACCCACCGGTGGTCTCAAAGATGTAGAACGCAGCGTGTGCCCACGCTCAGCAGGTGT
GCCATCCTTCCACCTGCTGGGGCACCATTCTTAGTATACAGAGGTGGCCTTACACACATCTTGCATGGATGGCAGCATTGTTCTGAAGGG
GTTTGCAGAAAAAAAAGATTTTCTTTACATAAAGTGAATCAAATTTGACATTATTTTAGATCCCAGAGAAATCAGGTGTGATTAGTTCTC
CAGGCATGAATGCATCGTCCCTTTATCTGTAAGAACCCTTAGTGTCCTGTAGGGGGACAGAATGGGGTGGCCAGGTGGTGATTTCTCTTT
GACCAATGCATAGTTTGGCAGAAAAATCAGCCGTTCATTTAGAAGAATCTTAGCAGAGATTGGGATGCCTTACTCAATAAAGCTAAGATG
ACTATGCTGCTGGCTGTCTTTGTTCTTGGAGAGGTGGAGTGACTGTTCACGGAGAATGCACGGCATGGGGATGAACCCTTTCCCTCTGCT
TTTGAGCCCTGTTCTGGGCTCCAAGGTGCTGTATGATCTAGGCCGTGCTGGCCAGGAGACAATCCTATGGGGATGGCAGTGGTGTCTTGT
GCTCTGTCCCCTAGAGCAGTCACTGGCCACAGGTAGCCACCTGCCTTTCTCCCGGCTTCCCTAGCAGAGTTTGCTCAGGCACAAATGTGC
ACCTGGAGCATTTGAAATGTGCTAGTGAGGCTGAGGAAGAGAATTTTAAATTTCATTGAATTGTAATCAGTTTAAAGTTAAATAGCAGCA
GCTGCCATGAGGCTCAGGCAGATCCAGCTCATCTTCCCCTCTGCCCCCTCCTCCCTATCTTCCCCTCTACCCTCTCCTGCCTCCTGTCAC
ATCCGGTTAGGCTCCCATCTCACTGATGTGTCTCCTGCAGTGGTCTCTCCCCTGCCCTGCTTCCAGCCCCAGAGTCCTGGAGCAGCAGCC
TCCTCACGGGTCTTGCCGCCCACATGGTTGGATCCTGAAACTCGCAGGGCCTCCCCCAACTGCCCCTGCCCACCCCCAGCCCGGCCCCAT

>27516_27516_9_ESCO2-EPHX2_ESCO2_chr8_27646495_ENST00000397418_EPHX2_chr8_27394301_ENST00000521400_length(amino acids)=309AA_BP=
MARLRRARRALRRRNSIKKMAALTPRKRKQDSLKCDSLLHFTENLFPSPNKKHCFYQNSDKNEENLHCSQQEHFVLSALKTTEINRLPSA
NQGSPFKSALSTVSFYNQNKWYLNPLERKLIKESRSTCLKTNDEDKSFPIVTEKMQGKPVCSKKNNKKPQKSLTAKYQPKYRHIKPVSRN
SRNSKQNRVIYKPIVEKENNCHSAENNSNAPRVLSQKIKPQVTLQGGAAFFVRKKSSLRKSSLENEPSLGRTQKSKSEVIEDSDVETVSE

--------------------------------------------------------------
>27516_27516_10_ESCO2-EPHX2_ESCO2_chr8_27646495_ENST00000397418_EPHX2_chr8_27394301_ENST00000521780_length(transcript)=2076nt_BP=1181nt
GCTCACGGAGCGGCTGGCTAGGCTGAGGAGAGCTCGCCGGGCTCTGAGGCGCAGGAATTCAATAAAGAAAATGGCAGCTCTTACTCCAAG
GAAGAGGAAGCAGGATTCTTTGAAGTGTGACAGCCTTTTACACTTCACTGAAAATCTGTTTCCATCACCTAATAAAAAGCACTGTTTTTA
TCAAAACAGTGATAAAAATGAAGAAAACCTGCATTGCTCTCAACAAGAGCATTTTGTTTTAAGTGCGCTCAAAACAACTGAAATAAATAG
ACTGCCATCAGCAAATCAAGGCTCACCATTTAAATCTGCGCTCTCCACTGTATCTTTTTACAACCAAAATAAGTGGTACCTCAATCCACT
GGAGAGAAAGCTGATAAAAGAGAGTAGATCTACTTGTCTAAAAACTAATGATGAAGATAAATCTTTTCCCATTGTGACAGAAAAAATGCA
AGGAAAACCAGTCTGCTCCAAGAAGAACAACAAAAAACCACAGAAGAGTTTAACTGCTAAGTATCAACCAAAGTATAGACACATCAAGCC
TGTATCAAGGAATTCTAGAAATTCCAAGCAAAATCGAGTGATCTATAAGCCAATTGTGGAGAAGGAAAATAATTGTCATTCAGCTGAAAA
TAATTCCAATGCTCCTCGGGTTCTGAGCCAAAAAATAAAACCACAAGTTACACTCCAGGGTGGAGCAGCATTTTTTGTTAGAAAAAAATC
TTCTCTTAGAAAATCGTCCCTGGAAAATGAGCCGTCACTGGGACGCACCCAAAAGAGTAAATCAGAAGTCATTGAAGATTCTGATGTAGA
GACTGTCAGTGAAAAAAAAACTTTTGCGACAAGGCAAGTGCCAAAGTGCTTGGTCCTAGAAGAGAAATTGAAAATTGGACTACTGAGTGC
AAGCAGTAAAAATAAAGAGAAATTAATAAAGATCTTTAGGTGAAGAACAGTTTTCTGTGGGATCTGTCAACTTCATGAAACAGACCAATA
TCCAGAAAAATACTAATACCAGAGATACAAGTAAAAAAACAAAAGACCAGCTCATCATCGACGCTGGTCAGAAACATTTTGGGGCTACTG
TGTGCAAGTCTTGTGGTATGATATATACTGCTTCCAACCCTGAAGATGAAATGCAGCATGTACAGCATCACCACAGGTTTCTGGAAGGAA
TCAAATATGTGGGAGTGGCTGAGGCTGAACTGGAACAGAACCTGAGTCGGACTTTCAAAAGCCTCTTCAGAGCAAGCGATGAGAGTGTTT
TATCCATGCATAAAGTCTGTGAAGCGGGAGGACTTTTTGTAAATAGCCCAGAAGAGCCCAGCCTCAGCAGGATGGTCACTGAGGAGGAAA
TCCAGTTCTATGTGCAGCAGTTCAAGAAGTCTGGTTTCAGAGGTCCTCTAAACTGGTACCGAAACATGGAAAGGAACTGGAAGTGGGCTT
GCAAAAGCTTGGGACGGAAGATCCTGATTCCGGCCCTGATGGTCACGGCGGAGAAGGACTTCGTGCTCGTTCCTCAGATGTCCCAGCACA
TGGAGGACTGGATTCCCCACCTGAAAAGGGGACACATTGAGGACTGTGGGCACTGGACACAGATGGACAAGCCAACCGAGGTGAATCAGA
TCCTCATTAAGTGGCTGGATTCTGATGCCCGGAACCCACCGGTGGTCTCAAAGATGTAGAACGCAGCGTGTGCCCACGCTCAGCAGGTGT
GCCATCCTTCCACCTGCTGGGGCACCATTCTTAGTATACAGAGGTGGCCTTACACACATCTTGCATGGATGGCAGCATTGTTCTGAAGGG
GTTTGCAGAAAAAAAAGATTTTCTTTACATAAAGTGAATCAAATTTGACATTATTTTAGATCCCAGAGAAATCAGGTGTGATTAGTTCTC
CAGGCATGAATGCATCGTCCCTTTATCTGTAAGAACCCTTAGTGTCCTGTAGGGGGACAGAATGGGGTGGCCAGGTGGTGATTTCTCTTT
GACCAATGCATAGTTTGGCAGAAAAATCAGCCGTTCATTTAGAAGAATCTTAGCAGAGATTGGGATGCCTTACTCAATAAAGCTAAGATG

>27516_27516_10_ESCO2-EPHX2_ESCO2_chr8_27646495_ENST00000397418_EPHX2_chr8_27394301_ENST00000521780_length(amino acids)=309AA_BP=
MARLRRARRALRRRNSIKKMAALTPRKRKQDSLKCDSLLHFTENLFPSPNKKHCFYQNSDKNEENLHCSQQEHFVLSALKTTEINRLPSA
NQGSPFKSALSTVSFYNQNKWYLNPLERKLIKESRSTCLKTNDEDKSFPIVTEKMQGKPVCSKKNNKKPQKSLTAKYQPKYRHIKPVSRN
SRNSKQNRVIYKPIVEKENNCHSAENNSNAPRVLSQKIKPQVTLQGGAAFFVRKKSSLRKSSLENEPSLGRTQKSKSEVIEDSDVETVSE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ESCO2-EPHX2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ESCO2-EPHX2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ESCO2-EPHX2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource