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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ESR1-MTHFD1L (FusionGDB2 ID:27544)

Fusion Gene Summary for ESR1-MTHFD1L

check button Fusion gene summary
Fusion gene informationFusion gene name: ESR1-MTHFD1L
Fusion gene ID: 27544
HgeneTgene
Gene symbol

ESR1

MTHFD1L

Gene ID

2099

25902

Gene nameestrogen receptor 1methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like
SynonymsER|ESR|ESRA|ESTRR|Era|NR3A1FTHFSDC1|MTC1THFS|dJ292B18.2
Cytomap

6q25.1-q25.2

6q25.1

Type of geneprotein-codingprotein-coding
Descriptionestrogen receptorE2 receptor alphaER-alphaestradiol receptorestrogen nuclear receptor alphaestrogen receptor alpha E1-E2-1-2estrogen receptor alpha E1-N2-E2-1-2nuclear receptor subfamily 3 group A member 1oestrogen receptor alphamonofunctional C1-tetrahydrofolate synthase, mitochondrial10-formyl-THF synthetaseformyltetrahydrofolate synthetase domain containing 1
Modification date2020032920200313
UniProtAcc

P03372

Q6UB35

Ensembl transtripts involved in fusion geneENST00000482101, ENST00000206249, 
ENST00000338799, ENST00000406599, 
ENST00000427531, ENST00000440973, 
ENST00000443427, ENST00000456483, 
ENST00000367321, ENST00000478643, 
ENST00000367307, 
Fusion gene scores* DoF score21 X 18 X 8=302414 X 17 X 13=3094
# samples 3527
** MAII scorelog2(35/3024*10)=-3.11103131238874
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(27/3094*10)=-3.51844188439821
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ESR1 [Title/Abstract] AND MTHFD1L [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointESR1(152129499)-MTHFD1L(151330954), # samples:2
ESR1(152265643)-MTHFD1L(151330955), # samples:2
Anticipated loss of major functional domain due to fusion event.ESR1-MTHFD1L seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
ESR1-MTHFD1L seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
ESR1-MTHFD1L seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
ESR1-MTHFD1L seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
ESR1-MTHFD1L seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
ESR1-MTHFD1L seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneESR1

GO:0006366

transcription by RNA polymerase II

15831516

HgeneESR1

GO:0010629

negative regulation of gene expression

21695196

HgeneESR1

GO:0030520

intracellular estrogen receptor signaling pathway

9841876

HgeneESR1

GO:0032355

response to estradiol

15304487

HgeneESR1

GO:0043124

negative regulation of I-kappaB kinase/NF-kappaB signaling

7651415|16043358

HgeneESR1

GO:0043433

negative regulation of DNA-binding transcription factor activity

10816575

HgeneESR1

GO:0043627

response to estrogen

11581164

HgeneESR1

GO:0045893

positive regulation of transcription, DNA-templated

9841876|20074560

HgeneESR1

GO:0045899

positive regulation of RNA polymerase II transcriptional preinitiation complex assembly

9841876

HgeneESR1

GO:0045944

positive regulation of transcription by RNA polymerase II

11544182|12047722|15345745|15831516|18563714

HgeneESR1

GO:0051091

positive regulation of DNA-binding transcription factor activity

9328340|10681512

HgeneESR1

GO:0071392

cellular response to estradiol stimulus

15831516

TgeneMTHFD1L

GO:0006760

folic acid-containing compound metabolic process

12937168

TgeneMTHFD1L

GO:0009257

10-formyltetrahydrofolate biosynthetic process

12937168

TgeneMTHFD1L

GO:0015942

formate metabolic process

16171773


check buttonFusion gene breakpoints across ESR1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MTHFD1L (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-BH-A5J0-01AESR1chr6

152265643

-MTHFD1Lchr6

151330955

+
ChimerDB4BRCATCGA-BH-A5J0-01AESR1chr6

152265643

+MTHFD1Lchr6

151330955

+
ChimerDB4COADTCGA-AA-3850ESR1chr6

152129499

+MTHFD1Lchr6

151330954

+
ChimerDB4OVTCGA-04-1517ESR1chr6

152382259

+MTHFD1Lchr6

151330954

+
ChimerDB4OVTCGA-29-1697-01AESR1chr6

152129499

+MTHFD1Lchr6

151330955

+
ChimerDB4OVTCGA-29-1697-01AESR1chr6

152130406

+MTHFD1Lchr6

151330955

+
ChimerDB4OVTCGA-29-1697ESR1chr6

152129499

+MTHFD1Lchr6

151330954

+


Top

Fusion Gene ORF analysis for ESR1-MTHFD1L

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000482101ENST00000367321ESR1chr6

152265643

+MTHFD1Lchr6

151330955

+
3UTR-3UTRENST00000482101ENST00000478643ESR1chr6

152265643

+MTHFD1Lchr6

151330955

+
3UTR-intronENST00000482101ENST00000367307ESR1chr6

152265643

+MTHFD1Lchr6

151330955

+
5CDS-3UTRENST00000206249ENST00000478643ESR1chr6

152265643

+MTHFD1Lchr6

151330955

+
5CDS-3UTRENST00000206249ENST00000478643ESR1chr6

152129499

+MTHFD1Lchr6

151330954

+
5CDS-3UTRENST00000206249ENST00000478643ESR1chr6

152382259

+MTHFD1Lchr6

151330954

+
5CDS-3UTRENST00000206249ENST00000478643ESR1chr6

152129499

+MTHFD1Lchr6

151330955

+
5CDS-3UTRENST00000338799ENST00000478643ESR1chr6

152265643

+MTHFD1Lchr6

151330955

+
5CDS-3UTRENST00000338799ENST00000478643ESR1chr6

152129499

+MTHFD1Lchr6

151330954

+
5CDS-3UTRENST00000338799ENST00000478643ESR1chr6

152382259

+MTHFD1Lchr6

151330954

+
5CDS-3UTRENST00000338799ENST00000478643ESR1chr6

152129499

+MTHFD1Lchr6

151330955

+
5CDS-3UTRENST00000406599ENST00000478643ESR1chr6

152129499

+MTHFD1Lchr6

151330954

+
5CDS-3UTRENST00000406599ENST00000478643ESR1chr6

152382259

+MTHFD1Lchr6

151330954

+
5CDS-3UTRENST00000406599ENST00000478643ESR1chr6

152129499

+MTHFD1Lchr6

151330955

+
5CDS-3UTRENST00000427531ENST00000478643ESR1chr6

152265643

+MTHFD1Lchr6

151330955

+
5CDS-3UTRENST00000427531ENST00000478643ESR1chr6

152382259

+MTHFD1Lchr6

151330954

+
5CDS-3UTRENST00000440973ENST00000478643ESR1chr6

152265643

+MTHFD1Lchr6

151330955

+
5CDS-3UTRENST00000440973ENST00000478643ESR1chr6

152129499

+MTHFD1Lchr6

151330954

+
5CDS-3UTRENST00000440973ENST00000478643ESR1chr6

152382259

+MTHFD1Lchr6

151330954

+
5CDS-3UTRENST00000440973ENST00000478643ESR1chr6

152129499

+MTHFD1Lchr6

151330955

+
5CDS-3UTRENST00000443427ENST00000478643ESR1chr6

152265643

+MTHFD1Lchr6

151330955

+
5CDS-3UTRENST00000443427ENST00000478643ESR1chr6

152129499

+MTHFD1Lchr6

151330954

+
5CDS-3UTRENST00000443427ENST00000478643ESR1chr6

152382259

+MTHFD1Lchr6

151330954

+
5CDS-3UTRENST00000443427ENST00000478643ESR1chr6

152129499

+MTHFD1Lchr6

151330955

+
5CDS-3UTRENST00000456483ENST00000478643ESR1chr6

152129499

+MTHFD1Lchr6

151330954

+
5CDS-3UTRENST00000456483ENST00000478643ESR1chr6

152382259

+MTHFD1Lchr6

151330954

+
5CDS-3UTRENST00000456483ENST00000478643ESR1chr6

152129499

+MTHFD1Lchr6

151330955

+
5CDS-intronENST00000206249ENST00000367307ESR1chr6

152265643

+MTHFD1Lchr6

151330955

+
5CDS-intronENST00000206249ENST00000367307ESR1chr6

152129499

+MTHFD1Lchr6

151330954

+
5CDS-intronENST00000206249ENST00000367307ESR1chr6

152382259

+MTHFD1Lchr6

151330954

+
5CDS-intronENST00000206249ENST00000367307ESR1chr6

152129499

+MTHFD1Lchr6

151330955

+
5CDS-intronENST00000338799ENST00000367307ESR1chr6

152265643

+MTHFD1Lchr6

151330955

+
5CDS-intronENST00000338799ENST00000367307ESR1chr6

152129499

+MTHFD1Lchr6

151330954

+
5CDS-intronENST00000338799ENST00000367307ESR1chr6

152382259

+MTHFD1Lchr6

151330954

+
5CDS-intronENST00000338799ENST00000367307ESR1chr6

152129499

+MTHFD1Lchr6

151330955

+
5CDS-intronENST00000406599ENST00000367307ESR1chr6

152129499

+MTHFD1Lchr6

151330954

+
5CDS-intronENST00000406599ENST00000367307ESR1chr6

152382259

+MTHFD1Lchr6

151330954

+
5CDS-intronENST00000406599ENST00000367307ESR1chr6

152129499

+MTHFD1Lchr6

151330955

+
5CDS-intronENST00000427531ENST00000367307ESR1chr6

152265643

+MTHFD1Lchr6

151330955

+
5CDS-intronENST00000427531ENST00000367307ESR1chr6

152382259

+MTHFD1Lchr6

151330954

+
5CDS-intronENST00000440973ENST00000367307ESR1chr6

152265643

+MTHFD1Lchr6

151330955

+
5CDS-intronENST00000440973ENST00000367307ESR1chr6

152129499

+MTHFD1Lchr6

151330954

+
5CDS-intronENST00000440973ENST00000367307ESR1chr6

152382259

+MTHFD1Lchr6

151330954

+
5CDS-intronENST00000440973ENST00000367307ESR1chr6

152129499

+MTHFD1Lchr6

151330955

+
5CDS-intronENST00000443427ENST00000367307ESR1chr6

152265643

+MTHFD1Lchr6

151330955

+
5CDS-intronENST00000443427ENST00000367307ESR1chr6

152129499

+MTHFD1Lchr6

151330954

+
5CDS-intronENST00000443427ENST00000367307ESR1chr6

152382259

+MTHFD1Lchr6

151330954

+
5CDS-intronENST00000443427ENST00000367307ESR1chr6

152129499

+MTHFD1Lchr6

151330955

+
5CDS-intronENST00000456483ENST00000367307ESR1chr6

152129499

+MTHFD1Lchr6

151330954

+
5CDS-intronENST00000456483ENST00000367307ESR1chr6

152382259

+MTHFD1Lchr6

151330954

+
5CDS-intronENST00000456483ENST00000367307ESR1chr6

152129499

+MTHFD1Lchr6

151330955

+
5UTR-3CDSENST00000427531ENST00000367321ESR1chr6

152130406

+MTHFD1Lchr6

151330955

+
5UTR-3UTRENST00000427531ENST00000478643ESR1chr6

152130406

+MTHFD1Lchr6

151330955

+
5UTR-intronENST00000427531ENST00000367307ESR1chr6

152130406

+MTHFD1Lchr6

151330955

+
Frame-shiftENST00000206249ENST00000367321ESR1chr6

152129499

+MTHFD1Lchr6

151330954

+
Frame-shiftENST00000206249ENST00000367321ESR1chr6

152129499

+MTHFD1Lchr6

151330955

+
Frame-shiftENST00000338799ENST00000367321ESR1chr6

152129499

+MTHFD1Lchr6

151330954

+
Frame-shiftENST00000338799ENST00000367321ESR1chr6

152129499

+MTHFD1Lchr6

151330955

+
Frame-shiftENST00000406599ENST00000367321ESR1chr6

152129499

+MTHFD1Lchr6

151330954

+
Frame-shiftENST00000406599ENST00000367321ESR1chr6

152129499

+MTHFD1Lchr6

151330955

+
Frame-shiftENST00000440973ENST00000367321ESR1chr6

152129499

+MTHFD1Lchr6

151330954

+
Frame-shiftENST00000440973ENST00000367321ESR1chr6

152129499

+MTHFD1Lchr6

151330955

+
Frame-shiftENST00000443427ENST00000367321ESR1chr6

152129499

+MTHFD1Lchr6

151330954

+
Frame-shiftENST00000443427ENST00000367321ESR1chr6

152129499

+MTHFD1Lchr6

151330955

+
Frame-shiftENST00000456483ENST00000367321ESR1chr6

152129499

+MTHFD1Lchr6

151330954

+
Frame-shiftENST00000456483ENST00000367321ESR1chr6

152129499

+MTHFD1Lchr6

151330955

+
In-frameENST00000206249ENST00000367321ESR1chr6

152265643

+MTHFD1Lchr6

151330955

+
In-frameENST00000206249ENST00000367321ESR1chr6

152382259

+MTHFD1Lchr6

151330954

+
In-frameENST00000338799ENST00000367321ESR1chr6

152265643

+MTHFD1Lchr6

151330955

+
In-frameENST00000338799ENST00000367321ESR1chr6

152382259

+MTHFD1Lchr6

151330954

+
In-frameENST00000406599ENST00000367321ESR1chr6

152382259

+MTHFD1Lchr6

151330954

+
In-frameENST00000427531ENST00000367321ESR1chr6

152265643

+MTHFD1Lchr6

151330955

+
In-frameENST00000427531ENST00000367321ESR1chr6

152382259

+MTHFD1Lchr6

151330954

+
In-frameENST00000440973ENST00000367321ESR1chr6

152265643

+MTHFD1Lchr6

151330955

+
In-frameENST00000440973ENST00000367321ESR1chr6

152382259

+MTHFD1Lchr6

151330954

+
In-frameENST00000443427ENST00000367321ESR1chr6

152265643

+MTHFD1Lchr6

151330955

+
In-frameENST00000443427ENST00000367321ESR1chr6

152382259

+MTHFD1Lchr6

151330954

+
In-frameENST00000456483ENST00000367321ESR1chr6

152382259

+MTHFD1Lchr6

151330954

+
intron-3CDSENST00000206249ENST00000367321ESR1chr6

152130406

+MTHFD1Lchr6

151330955

+
intron-3CDSENST00000338799ENST00000367321ESR1chr6

152130406

+MTHFD1Lchr6

151330955

+
intron-3CDSENST00000406599ENST00000367321ESR1chr6

152265643

+MTHFD1Lchr6

151330955

+
intron-3CDSENST00000406599ENST00000367321ESR1chr6

152130406

+MTHFD1Lchr6

151330955

+
intron-3CDSENST00000427531ENST00000367321ESR1chr6

152129499

+MTHFD1Lchr6

151330954

+
intron-3CDSENST00000427531ENST00000367321ESR1chr6

152129499

+MTHFD1Lchr6

151330955

+
intron-3CDSENST00000440973ENST00000367321ESR1chr6

152130406

+MTHFD1Lchr6

151330955

+
intron-3CDSENST00000443427ENST00000367321ESR1chr6

152130406

+MTHFD1Lchr6

151330955

+
intron-3CDSENST00000456483ENST00000367321ESR1chr6

152265643

+MTHFD1Lchr6

151330955

+
intron-3CDSENST00000456483ENST00000367321ESR1chr6

152130406

+MTHFD1Lchr6

151330955

+
intron-3CDSENST00000482101ENST00000367321ESR1chr6

152129499

+MTHFD1Lchr6

151330954

+
intron-3CDSENST00000482101ENST00000367321ESR1chr6

152382259

+MTHFD1Lchr6

151330954

+
intron-3CDSENST00000482101ENST00000367321ESR1chr6

152129499

+MTHFD1Lchr6

151330955

+
intron-3CDSENST00000482101ENST00000367321ESR1chr6

152130406

+MTHFD1Lchr6

151330955

+
intron-3UTRENST00000206249ENST00000478643ESR1chr6

152130406

+MTHFD1Lchr6

151330955

+
intron-3UTRENST00000338799ENST00000478643ESR1chr6

152130406

+MTHFD1Lchr6

151330955

+
intron-3UTRENST00000406599ENST00000478643ESR1chr6

152265643

+MTHFD1Lchr6

151330955

+
intron-3UTRENST00000406599ENST00000478643ESR1chr6

152130406

+MTHFD1Lchr6

151330955

+
intron-3UTRENST00000427531ENST00000478643ESR1chr6

152129499

+MTHFD1Lchr6

151330954

+
intron-3UTRENST00000427531ENST00000478643ESR1chr6

152129499

+MTHFD1Lchr6

151330955

+
intron-3UTRENST00000440973ENST00000478643ESR1chr6

152130406

+MTHFD1Lchr6

151330955

+
intron-3UTRENST00000443427ENST00000478643ESR1chr6

152130406

+MTHFD1Lchr6

151330955

+
intron-3UTRENST00000456483ENST00000478643ESR1chr6

152265643

+MTHFD1Lchr6

151330955

+
intron-3UTRENST00000456483ENST00000478643ESR1chr6

152130406

+MTHFD1Lchr6

151330955

+
intron-3UTRENST00000482101ENST00000478643ESR1chr6

152129499

+MTHFD1Lchr6

151330954

+
intron-3UTRENST00000482101ENST00000478643ESR1chr6

152382259

+MTHFD1Lchr6

151330954

+
intron-3UTRENST00000482101ENST00000478643ESR1chr6

152129499

+MTHFD1Lchr6

151330955

+
intron-3UTRENST00000482101ENST00000478643ESR1chr6

152130406

+MTHFD1Lchr6

151330955

+
intron-intronENST00000206249ENST00000367307ESR1chr6

152130406

+MTHFD1Lchr6

151330955

+
intron-intronENST00000338799ENST00000367307ESR1chr6

152130406

+MTHFD1Lchr6

151330955

+
intron-intronENST00000406599ENST00000367307ESR1chr6

152265643

+MTHFD1Lchr6

151330955

+
intron-intronENST00000406599ENST00000367307ESR1chr6

152130406

+MTHFD1Lchr6

151330955

+
intron-intronENST00000427531ENST00000367307ESR1chr6

152129499

+MTHFD1Lchr6

151330954

+
intron-intronENST00000427531ENST00000367307ESR1chr6

152129499

+MTHFD1Lchr6

151330955

+
intron-intronENST00000440973ENST00000367307ESR1chr6

152130406

+MTHFD1Lchr6

151330955

+
intron-intronENST00000443427ENST00000367307ESR1chr6

152130406

+MTHFD1Lchr6

151330955

+
intron-intronENST00000456483ENST00000367307ESR1chr6

152265643

+MTHFD1Lchr6

151330955

+
intron-intronENST00000456483ENST00000367307ESR1chr6

152130406

+MTHFD1Lchr6

151330955

+
intron-intronENST00000482101ENST00000367307ESR1chr6

152129499

+MTHFD1Lchr6

151330954

+
intron-intronENST00000482101ENST00000367307ESR1chr6

152382259

+MTHFD1Lchr6

151330954

+
intron-intronENST00000482101ENST00000367307ESR1chr6

152129499

+MTHFD1Lchr6

151330955

+
intron-intronENST00000482101ENST00000367307ESR1chr6

152130406

+MTHFD1Lchr6

151330955

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000440973ESR1chr6152382259+ENST00000367321MTHFD1Lchr6151330954+294417393702550726
ENST00000338799ESR1chr6152382259+ENST00000367321MTHFD1Lchr6151330954+4034282914603640726
ENST00000456483ESR1chr6152382259+ENST00000367321MTHFD1Lchr6151330954+245612512182062614
ENST00000443427ESR1chr6152382259+ENST00000367321MTHFD1Lchr6151330954+283516302612441726
ENST00000206249ESR1chr6152382259+ENST00000367321MTHFD1Lchr6151330954+293617313622542726
ENST00000406599ESR1chr6152382259+ENST00000367321MTHFD1Lchr6151330954+20258202341631465
ENST00000427531ESR1chr6152382259+ENST00000367321MTHFD1Lchr6151330954+228710822051893562
ENST00000440973ESR1chr6152265643+ENST00000367321MTHFD1Lchr6151330955+267114663702277635
ENST00000338799ESR1chr6152265643+ENST00000367321MTHFD1Lchr6151330955+3761255614603367635
ENST00000443427ESR1chr6152265643+ENST00000367321MTHFD1Lchr6151330955+256213572612168635
ENST00000206249ESR1chr6152265643+ENST00000367321MTHFD1Lchr6151330955+266314583622269635
ENST00000427531ESR1chr6152265643+ENST00000367321MTHFD1Lchr6151330955+20148092051620471

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000440973ENST00000367321ESR1chr6152382259+MTHFD1Lchr6151330954+0.0025102860.9974897
ENST00000338799ENST00000367321ESR1chr6152382259+MTHFD1Lchr6151330954+0.0013212120.99867874
ENST00000456483ENST00000367321ESR1chr6152382259+MTHFD1Lchr6151330954+0.0026261130.99737394
ENST00000443427ENST00000367321ESR1chr6152382259+MTHFD1Lchr6151330954+0.0023272630.99767274
ENST00000206249ENST00000367321ESR1chr6152382259+MTHFD1Lchr6151330954+0.0020635690.9979365
ENST00000406599ENST00000367321ESR1chr6152382259+MTHFD1Lchr6151330954+0.0031695520.9968304
ENST00000427531ENST00000367321ESR1chr6152382259+MTHFD1Lchr6151330954+0.0017158330.99828416
ENST00000440973ENST00000367321ESR1chr6152265643+MTHFD1Lchr6151330955+0.0036151390.99638486
ENST00000338799ENST00000367321ESR1chr6152265643+MTHFD1Lchr6151330955+0.001826680.99817336
ENST00000443427ENST00000367321ESR1chr6152265643+MTHFD1Lchr6151330955+0.0035336940.9964663
ENST00000206249ENST00000367321ESR1chr6152265643+MTHFD1Lchr6151330955+0.0031022310.9968978
ENST00000427531ENST00000367321ESR1chr6152265643+MTHFD1Lchr6151330955+0.0024127790.9975872

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Fusion Genomic Features for ESR1-MTHFD1L


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ESR1chr6152130406+MTHFD1Lchr6151330954+0.0029406920.99705935
ESR1chr6152382259+MTHFD1Lchr6151330954+1.57E-050.99998426
ESR1chr6152265643+MTHFD1Lchr6151330954+1.79E-070.99999976
ESR1chr6152129499+MTHFD1Lchr6151330954+3.70E-091
ESR1chr6152129499+MTHFD1Lchr6151330954+3.70E-091
ESR1chr6152129499+MTHFD1Lchr6151330954+3.70E-091
ESR1chr6152130406+MTHFD1Lchr6151330954+0.0029406920.99705935
ESR1chr6152382259+MTHFD1Lchr6151330954+1.57E-050.99998426
ESR1chr6152265643+MTHFD1Lchr6151330954+1.79E-070.99999976
ESR1chr6152129499+MTHFD1Lchr6151330954+3.70E-091
ESR1chr6152129499+MTHFD1Lchr6151330954+3.70E-091
ESR1chr6152129499+MTHFD1Lchr6151330954+3.70E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ESR1-MTHFD1L


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:152129499/chr6:151330954)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ESR1

P03372

MTHFD1L

Q6UB35

FUNCTION: Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Isoform 3 is involved in activation of NOS3 and endothelial nitric oxide production. Isoforms lacking one or several functional domains are thought to modulate transcriptional activity by competitive ligand or DNA binding and/or heterodimerization with the full-length receptor. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3. Isoform 3 can bind to ERE and inhibit isoform 1. {ECO:0000269|PubMed:10681512, ECO:0000269|PubMed:10816575, ECO:0000269|PubMed:11477071, ECO:0000269|PubMed:11682626, ECO:0000269|PubMed:14764652, ECO:0000269|PubMed:15078875, ECO:0000269|PubMed:15891768, ECO:0000269|PubMed:16043358, ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:16684779, ECO:0000269|PubMed:17922032, ECO:0000269|PubMed:17932106, ECO:0000269|PubMed:18247370, ECO:0000269|PubMed:19350539, ECO:0000269|PubMed:20074560, ECO:0000269|PubMed:20705611, ECO:0000269|PubMed:21330404, ECO:0000269|PubMed:22083956, ECO:0000269|PubMed:7651415, ECO:0000269|PubMed:9328340}.FUNCTION: May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism in embryonic an transformed cells complementing thus the enzymatic activities of MTHFD2. {ECO:0000250, ECO:0000269|PubMed:16171773}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneESR1chr6:152265643chr6:151330955ENST00000206249+48185_250365596.0DNA bindingNuclear receptor
HgeneESR1chr6:152265643chr6:151330955ENST00000338799+59185_250365596.0DNA bindingNuclear receptor
HgeneESR1chr6:152265643chr6:151330955ENST00000440973+610185_250365596.0DNA bindingNuclear receptor
HgeneESR1chr6:152265643chr6:151330955ENST00000443427+59185_250365596.0DNA bindingNuclear receptor
HgeneESR1chr6:152382259chr6:151330954ENST00000206249+68185_250456596.0DNA bindingNuclear receptor
HgeneESR1chr6:152382259chr6:151330954ENST00000338799+79185_250456596.0DNA bindingNuclear receptor
HgeneESR1chr6:152382259chr6:151330954ENST00000440973+810185_250456596.0DNA bindingNuclear receptor
HgeneESR1chr6:152382259chr6:151330954ENST00000443427+79185_250456596.0DNA bindingNuclear receptor
HgeneESR1chr6:152382259chr6:151330954ENST00000456483+68185_250344484.0DNA bindingNuclear receptor
HgeneESR1chr6:152265643chr6:151330955ENST00000206249+48251_310365596.0RegionNote=Hinge
HgeneESR1chr6:152265643chr6:151330955ENST00000338799+59251_310365596.0RegionNote=Hinge
HgeneESR1chr6:152265643chr6:151330955ENST00000440973+610251_310365596.0RegionNote=Hinge
HgeneESR1chr6:152265643chr6:151330955ENST00000443427+59251_310365596.0RegionNote=Hinge
HgeneESR1chr6:152382259chr6:151330954ENST00000206249+68251_310456596.0RegionNote=Hinge
HgeneESR1chr6:152382259chr6:151330954ENST00000338799+79251_310456596.0RegionNote=Hinge
HgeneESR1chr6:152382259chr6:151330954ENST00000440973+810251_310456596.0RegionNote=Hinge
HgeneESR1chr6:152382259chr6:151330954ENST00000443427+79251_310456596.0RegionNote=Hinge
HgeneESR1chr6:152382259chr6:151330954ENST00000456483+68251_310344484.0RegionNote=Hinge
HgeneESR1chr6:152265643chr6:151330955ENST00000206249+48185_205365596.0Zinc fingerNR C4-type
HgeneESR1chr6:152265643chr6:151330955ENST00000206249+48221_245365596.0Zinc fingerNR C4-type
HgeneESR1chr6:152265643chr6:151330955ENST00000338799+59185_205365596.0Zinc fingerNR C4-type
HgeneESR1chr6:152265643chr6:151330955ENST00000338799+59221_245365596.0Zinc fingerNR C4-type
HgeneESR1chr6:152265643chr6:151330955ENST00000440973+610185_205365596.0Zinc fingerNR C4-type
HgeneESR1chr6:152265643chr6:151330955ENST00000440973+610221_245365596.0Zinc fingerNR C4-type
HgeneESR1chr6:152265643chr6:151330955ENST00000443427+59185_205365596.0Zinc fingerNR C4-type
HgeneESR1chr6:152265643chr6:151330955ENST00000443427+59221_245365596.0Zinc fingerNR C4-type
HgeneESR1chr6:152382259chr6:151330954ENST00000206249+68185_205456596.0Zinc fingerNR C4-type
HgeneESR1chr6:152382259chr6:151330954ENST00000206249+68221_245456596.0Zinc fingerNR C4-type
HgeneESR1chr6:152382259chr6:151330954ENST00000338799+79185_205456596.0Zinc fingerNR C4-type
HgeneESR1chr6:152382259chr6:151330954ENST00000338799+79221_245456596.0Zinc fingerNR C4-type
HgeneESR1chr6:152382259chr6:151330954ENST00000440973+810185_205456596.0Zinc fingerNR C4-type
HgeneESR1chr6:152382259chr6:151330954ENST00000440973+810221_245456596.0Zinc fingerNR C4-type
HgeneESR1chr6:152382259chr6:151330954ENST00000443427+79185_205456596.0Zinc fingerNR C4-type
HgeneESR1chr6:152382259chr6:151330954ENST00000443427+79221_245456596.0Zinc fingerNR C4-type
HgeneESR1chr6:152382259chr6:151330954ENST00000456483+68185_205344484.0Zinc fingerNR C4-type
HgeneESR1chr6:152382259chr6:151330954ENST00000456483+68221_245344484.0Zinc fingerNR C4-type
TgeneMTHFD1Lchr6:152265643chr6:151330955ENST000003673070834_420276.0Compositional biasNote=Poly-Gly
TgeneMTHFD1Lchr6:152382259chr6:151330954ENST000003673070834_420276.0Compositional biasNote=Poly-Gly
TgeneMTHFD1Lchr6:152265643chr6:151330955ENST0000036730708423_4300276.0Nucleotide bindingATP
TgeneMTHFD1Lchr6:152382259chr6:151330954ENST0000036730708423_4300276.0Nucleotide bindingATP
TgeneMTHFD1Lchr6:152265643chr6:151330955ENST000003673070831_3480276.0RegionNote=Methylenetetrahydrofolate dehydrogenase and cyclohydrolase
TgeneMTHFD1Lchr6:152265643chr6:151330955ENST0000036730708349_9780276.0RegionNote=Formyltetrahydrofolate synthetase
TgeneMTHFD1Lchr6:152382259chr6:151330954ENST000003673070831_3480276.0RegionNote=Methylenetetrahydrofolate dehydrogenase and cyclohydrolase
TgeneMTHFD1Lchr6:152382259chr6:151330954ENST0000036730708349_9780276.0RegionNote=Formyltetrahydrofolate synthetase

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneESR1chr6:152265643chr6:151330955ENST00000456483+18185_2500484.0DNA bindingNuclear receptor
HgeneESR1chr6:152265643chr6:151330955ENST00000206249+48311_547365596.0DomainNR LBD
HgeneESR1chr6:152265643chr6:151330955ENST00000338799+59311_547365596.0DomainNR LBD
HgeneESR1chr6:152265643chr6:151330955ENST00000440973+610311_547365596.0DomainNR LBD
HgeneESR1chr6:152265643chr6:151330955ENST00000443427+59311_547365596.0DomainNR LBD
HgeneESR1chr6:152265643chr6:151330955ENST00000456483+18311_5470484.0DomainNR LBD
HgeneESR1chr6:152382259chr6:151330954ENST00000206249+68311_547456596.0DomainNR LBD
HgeneESR1chr6:152382259chr6:151330954ENST00000338799+79311_547456596.0DomainNR LBD
HgeneESR1chr6:152382259chr6:151330954ENST00000440973+810311_547456596.0DomainNR LBD
HgeneESR1chr6:152382259chr6:151330954ENST00000443427+79311_547456596.0DomainNR LBD
HgeneESR1chr6:152382259chr6:151330954ENST00000456483+68311_547344484.0DomainNR LBD
HgeneESR1chr6:152265643chr6:151330955ENST00000206249+48264_595365596.0RegionNote=Self-association
HgeneESR1chr6:152265643chr6:151330955ENST00000206249+48311_595365596.0RegionNote=Transactivation AF-2
HgeneESR1chr6:152265643chr6:151330955ENST00000338799+59264_595365596.0RegionNote=Self-association
HgeneESR1chr6:152265643chr6:151330955ENST00000338799+59311_595365596.0RegionNote=Transactivation AF-2
HgeneESR1chr6:152265643chr6:151330955ENST00000440973+610264_595365596.0RegionNote=Self-association
HgeneESR1chr6:152265643chr6:151330955ENST00000440973+610311_595365596.0RegionNote=Transactivation AF-2
HgeneESR1chr6:152265643chr6:151330955ENST00000443427+59264_595365596.0RegionNote=Self-association
HgeneESR1chr6:152265643chr6:151330955ENST00000443427+59311_595365596.0RegionNote=Transactivation AF-2
HgeneESR1chr6:152265643chr6:151330955ENST00000456483+18251_3100484.0RegionNote=Hinge
HgeneESR1chr6:152265643chr6:151330955ENST00000456483+18264_5950484.0RegionNote=Self-association
HgeneESR1chr6:152265643chr6:151330955ENST00000456483+18311_5950484.0RegionNote=Transactivation AF-2
HgeneESR1chr6:152382259chr6:151330954ENST00000206249+68264_595456596.0RegionNote=Self-association
HgeneESR1chr6:152382259chr6:151330954ENST00000206249+68311_595456596.0RegionNote=Transactivation AF-2
HgeneESR1chr6:152382259chr6:151330954ENST00000338799+79264_595456596.0RegionNote=Self-association
HgeneESR1chr6:152382259chr6:151330954ENST00000338799+79311_595456596.0RegionNote=Transactivation AF-2
HgeneESR1chr6:152382259chr6:151330954ENST00000440973+810264_595456596.0RegionNote=Self-association
HgeneESR1chr6:152382259chr6:151330954ENST00000440973+810311_595456596.0RegionNote=Transactivation AF-2
HgeneESR1chr6:152382259chr6:151330954ENST00000443427+79264_595456596.0RegionNote=Self-association
HgeneESR1chr6:152382259chr6:151330954ENST00000443427+79311_595456596.0RegionNote=Transactivation AF-2
HgeneESR1chr6:152382259chr6:151330954ENST00000456483+68264_595344484.0RegionNote=Self-association
HgeneESR1chr6:152382259chr6:151330954ENST00000456483+68311_595344484.0RegionNote=Transactivation AF-2
HgeneESR1chr6:152265643chr6:151330955ENST00000456483+18185_2050484.0Zinc fingerNR C4-type
HgeneESR1chr6:152265643chr6:151330955ENST00000456483+18221_2450484.0Zinc fingerNR C4-type
TgeneMTHFD1Lchr6:152265643chr6:151330955ENST00000367321192834_42708932.6666666666666Compositional biasNote=Poly-Gly
TgeneMTHFD1Lchr6:152382259chr6:151330954ENST00000367321192834_42708932.6666666666666Compositional biasNote=Poly-Gly
TgeneMTHFD1Lchr6:152265643chr6:151330955ENST000003673211928423_430708932.6666666666666Nucleotide bindingATP
TgeneMTHFD1Lchr6:152382259chr6:151330954ENST000003673211928423_430708932.6666666666666Nucleotide bindingATP
TgeneMTHFD1Lchr6:152265643chr6:151330955ENST00000367321192831_348708932.6666666666666RegionNote=Methylenetetrahydrofolate dehydrogenase and cyclohydrolase
TgeneMTHFD1Lchr6:152265643chr6:151330955ENST000003673211928349_978708932.6666666666666RegionNote=Formyltetrahydrofolate synthetase
TgeneMTHFD1Lchr6:152382259chr6:151330954ENST00000367321192831_348708932.6666666666666RegionNote=Methylenetetrahydrofolate dehydrogenase and cyclohydrolase
TgeneMTHFD1Lchr6:152382259chr6:151330954ENST000003673211928349_978708932.6666666666666RegionNote=Formyltetrahydrofolate synthetase


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Fusion Gene Sequence for ESR1-MTHFD1L


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>27544_27544_1_ESR1-MTHFD1L_ESR1_chr6_152265643_ENST00000206249_MTHFD1L_chr6_151330955_ENST00000367321_length(transcript)=2663nt_BP=1458nt
GAGTTGTGCCTGGAGTGATGTTTAAGCCAATGTCAGGGCAAGGCAACAGTCCCTGGCCGTCCTCCAGCACCTTTGTAATGCATATGAGCT
CGGGAGACCAGTACTTAAAGTTGGAGGCCCGGGAGCCCAGGAGCTGGCGGAGGGCGTTCGTCCTGGGACTGCACTTGCTCCCGTCGGGTC
GCCCGGCTTCACCGGACCCGCAGGCTCCCGGGGCAGGGCCGGGGCCAGAGCTCGCGTGTCGGCGGGACATGCGCTGCGTCGCCTCTAACC
TCGGGCTGTGCTCTTTTTCCAGGTGGCCCGCCGGTTTCTGAGCCTTCTGCCCTGCGGGGACACGGTCTGCACCCTGCCCGCGGCCACGGA
CCATGACCATGACCCTCCACACCAAAGCATCTGGGATGGCCCTACTGCATCAGATCCAAGGGAACGAGCTGGAGCCCCTGAACCGTCCGC
AGCTCAAGATCCCCCTGGAGCGGCCCCTGGGCGAGGTGTACCTGGACAGCAGCAAGCCCGCCGTGTACAACTACCCCGAGGGCGCCGCCT
ACGAGTTCAACGCCGCGGCCGCCGCCAACGCGCAGGTCTACGGTCAGACCGGCCTCCCCTACGGCCCCGGGTCTGAGGCTGCGGCGTTCG
GCTCCAACGGCCTGGGGGGTTTCCCCCCACTCAACAGCGTGTCTCCGAGCCCGCTGATGCTACTGCACCCGCCGCCGCAGCTGTCGCCTT
TCCTGCAGCCCCACGGCCAGCAGGTGCCCTACTACCTGGAGAACGAGCCCAGCGGCTACACGGTGCGCGAGGCCGGCCCGCCGGCATTCT
ACAGGCCAAATTCAGATAATCGACGCCAGGGTGGCAGAGAAAGATTGGCCAGTACCAATGACAAGGGAAGTATGGCTATGGAATCTGCCA
AGGAGACTCGCTACTGTGCAGTGTGCAATGACTATGCTTCAGGCTACCATTATGGAGTCTGGTCCTGTGAGGGCTGCAAGGCCTTCTTCA
AGAGAAGTATTCAAGGACATAACGACTATATGTGTCCAGCCACCAACCAGTGCACCATTGATAAAAACAGGAGGAAGAGCTGCCAGGCCT
GCCGGCTCCGTAAATGCTACGAAGTGGGAATGATGAAAGGTGGGATACGAAAAGACCGAAGAGGAGGGAGAATGTTGAAACACAAGCGCC
AGAGAGATGATGGGGAGGGCAGGGGTGAAGTGGGGTCTGCTGGAGACATGAGAGCTGCCAACCTTTGGCCAAGCCCGCTCATGATCAAAC
GCTCTAAGAAGAACAGCCTGGCCTTGTCCCTGACGGCCGACCAGATGGTCAGTGCCTTGTTGGATGCTGAGCCCCCGATACTCTATTCCG
AGTATGATCCTACCAGACCCTTCAGTGAAGCTTCGATGATGGGCTTACTGACCAACCTGGCAGACAGGGAGCTGGTTCACATGATCAACT
GGGCGAAGAGGGTGCCAGTGACCGAAGCTGGCTTTGGTGCTGACATCGGAATGGAGAAATTCTTCAACATCAAGTGCCGAGCTTCCGGCT
TGGTGCCCAACGTGGTTGTGTTAGTGGCAACGGTGCGAGCTCTGAAGATGCATGGAGGCGGGCCAAGTGTAACGGCTGGTGTTCCTCTTA
AGAAAGAATATACAGAGGAGAACATCCAGCTGGTGGCAGACGGCTGCTGTAACCTCCAGAAGCAAATTCAGATCACTCAGCTCTTTGGGG
TTCCCGTTGTGGTGGCTCTGAATGTCTTCAAGACCGACACCCGCGCTGAGATTGACTTGGTGTGTGAGCTTGCAAAGCGGGCTGGTGCCT
TTGATGCAGTCCCCTGCTATCACTGGTCCGTTGGTGGAAAAGGATCGGTGGACTTGGCTCGGGCTGTGAGAGAGGCTGCGAGTAAAAGAA
GCCGATTCCAGTTCCTGTATGATGTTCAGGTTCCAATTGTGGACAAGATAAGGACCATTGCTCAGGCTGTCTATGGAGCCAAAGATATTG
AACTCTCTCCTGAGGCACAAGCCAAAATAGATCGTTACACTCAACAGGGTTTTGGAAATTTGCCCATCTGCATGGCAAAGACCCACCTTT
CTCTATCTCACCAACCTGACAAAAAAGGTGTGCCAAGGGACTTCATCTTACCTATCAGTGACGTCCGGGCCAGCATAGGCGCTGGGTTCA
TTTACCCTTTGGTCGGAACGATGAGCACCATGCCAGGACTGCCCACCCGGCCCTGCTTTTATGACATAGATCTTGATACCGAAACAGAAC
AAGTTAAAGGCTTGTTCTAAGTGGACAAGGCTCTCACAGGACCCGATGCAGACTCCTGAAACAGACTACTCTTTGCCTTTTTGCTGCAGT
TGGAGAAGAAACTGAATTTGAAAAATGTCTGTTATGCAATGCTGGAGACATGGTGAAATAGGCCAAAGATTTCTTCTTCGTTCAAGATGA
ATTCTGTTCACAGTGGAGTATGGTGTTCGGCAAAAGGACCTCCACCAAGACTGAAAGAAACTAATTTATTTCTGTTTCTGTGGAGTTTCC
ATTATTTCTACTGCTTACACTTTAGAATGTTTATTTTATGGGGACTAAGGGATTAGGAGTGTGAACTAAAAGGTAACATTTTCCACTCTC

>27544_27544_1_ESR1-MTHFD1L_ESR1_chr6_152265643_ENST00000206249_MTHFD1L_chr6_151330955_ENST00000367321_length(amino acids)=635AA_BP=365
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFG
SNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK
ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQ
RDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINW
AKRVPVTEAGFGADIGMEKFFNIKCRASGLVPNVVVLVATVRALKMHGGGPSVTAGVPLKKEYTEENIQLVADGCCNLQKQIQITQLFGV
PVVVALNVFKTDTRAEIDLVCELAKRAGAFDAVPCYHWSVGGKGSVDLARAVREAASKRSRFQFLYDVQVPIVDKIRTIAQAVYGAKDIE
LSPEAQAKIDRYTQQGFGNLPICMAKTHLSLSHQPDKKGVPRDFILPISDVRASIGAGFIYPLVGTMSTMPGLPTRPCFYDIDLDTETEQ

--------------------------------------------------------------
>27544_27544_2_ESR1-MTHFD1L_ESR1_chr6_152265643_ENST00000338799_MTHFD1L_chr6_151330955_ENST00000367321_length(transcript)=3761nt_BP=2556nt
CTAGAGCATGGGTGGCCATTGTTGACCTACAGGAGGCACCACTGTCACCAACAAAGGGTAACAGTCTTTCTTTTCAATATTTATTTATAT
CCAGTATTTATTTTCAATACTGACTATGGAGAGAGCTCTCCTGTGCTCAAACACTGCAATACTGGGGGTCTTTCAAAGCACAAAAACATA
TATTTGCATGATGGCATCATTAACATTTTTATGGCTTTCTATTTCTTTTTTGTACTGGTCTCAAGAGCCACTCATAAATCTCTCAGTAAC
TGCATAGTGTCCCAGGGCCAGAGACCGGCCACTCCTGGCATTGTGATTAGAGTCATTTAATATCCAAGGTGGTGACTAATGTCTGGCAAC
AAAGCCTCCATTGGGTGTCATGTGTCCTGGGACCCTGAGCGTGGGCACTCTAGGAGCACCTCAGTATTGCGTGTTAGTACTATGGCCGAG
AGAATAGTTGAGAAAGTGGTCAAGAGGTGGATCCATGTGAACGCCACTGGGAAATGAGAGACCTCGTTCCCAATCACGGTCAGTGCAACT
CGAAAGCCTAAAATCAGTTTAAAACAAAGGTATCTACCTTTATCTTATGTTCATATCCTAGGCTTTTAATAATACGTATTTTTCACATGT
TTACAGAAAGCAGTCAACTGAGCTATTCATGGAAAGGTTTGTGGGTTTGGTTAACGAAGTGGAGGAGTATTACATTTCAGCTGGAAACAC
ATCCCTAGAATGCCAAAACATTTATTCCAAAGTCTGGTTTCCTGGTGCAATCGGAGGCATGGCAATGCCTCTGTTCAGAGACTGGGGGCT
AGGGCCAGTAAGGCATTTGATCCACATGTATCCCAGAAGGCTTTTATTGTTAAATTATATTCTTTCGGAAAAACCACCCATGTCCTATTT
TGTAAACTTGATATCCATACACTTTTGACTGGCATTCTATTTTAGCCGTAAGACTATGATTCACAGCAAGCCTGTTTTTCCTCTTGCTTG
GGGTGGCAGCAGAAAGCATAGGGTACTTTCCAGCCTCCAAGGGTAGGGGCAAAGGGGCTGGGGTTTCTCCTCCCCAGTACAGCTTTCTCT
GGCTGTGCCACACTGCTCCCTGTGAGCAGACAGCAAGTCTCCCCTCACTCCCCACTGCCATTCATCCAGCGCTGTGCAGTAGCCCAGCTG
CGTGTCTGCCGGGAGGGGCTGCCAAGTGCCCTGCCTACTGGCTGCTTCCCGAATCCCTGCCATTCCACGCACAAACACATCCACACACTC
TCTCTGCCTAGTTCACACACTGAGCCACTCGCACATGCGAGCACATTCCTTCCTTCCTTCTCACTCTCTCGGCCCTTGACTTCTACAAGC
CCATGGAACATTTCTGGAAAGACGTTCTTGATCCAGCAGGGTGGCCCGCCGGTTTCTGAGCCTTCTGCCCTGCGGGGACACGGTCTGCAC
CCTGCCCGCGGCCACGGACCATGACCATGACCCTCCACACCAAAGCATCTGGGATGGCCCTACTGCATCAGATCCAAGGGAACGAGCTGG
AGCCCCTGAACCGTCCGCAGCTCAAGATCCCCCTGGAGCGGCCCCTGGGCGAGGTGTACCTGGACAGCAGCAAGCCCGCCGTGTACAACT
ACCCCGAGGGCGCCGCCTACGAGTTCAACGCCGCGGCCGCCGCCAACGCGCAGGTCTACGGTCAGACCGGCCTCCCCTACGGCCCCGGGT
CTGAGGCTGCGGCGTTCGGCTCCAACGGCCTGGGGGGTTTCCCCCCACTCAACAGCGTGTCTCCGAGCCCGCTGATGCTACTGCACCCGC
CGCCGCAGCTGTCGCCTTTCCTGCAGCCCCACGGCCAGCAGGTGCCCTACTACCTGGAGAACGAGCCCAGCGGCTACACGGTGCGCGAGG
CCGGCCCGCCGGCATTCTACAGGCCAAATTCAGATAATCGACGCCAGGGTGGCAGAGAAAGATTGGCCAGTACCAATGACAAGGGAAGTA
TGGCTATGGAATCTGCCAAGGAGACTCGCTACTGTGCAGTGTGCAATGACTATGCTTCAGGCTACCATTATGGAGTCTGGTCCTGTGAGG
GCTGCAAGGCCTTCTTCAAGAGAAGTATTCAAGGACATAACGACTATATGTGTCCAGCCACCAACCAGTGCACCATTGATAAAAACAGGA
GGAAGAGCTGCCAGGCCTGCCGGCTCCGTAAATGCTACGAAGTGGGAATGATGAAAGGTGGGATACGAAAAGACCGAAGAGGAGGGAGAA
TGTTGAAACACAAGCGCCAGAGAGATGATGGGGAGGGCAGGGGTGAAGTGGGGTCTGCTGGAGACATGAGAGCTGCCAACCTTTGGCCAA
GCCCGCTCATGATCAAACGCTCTAAGAAGAACAGCCTGGCCTTGTCCCTGACGGCCGACCAGATGGTCAGTGCCTTGTTGGATGCTGAGC
CCCCGATACTCTATTCCGAGTATGATCCTACCAGACCCTTCAGTGAAGCTTCGATGATGGGCTTACTGACCAACCTGGCAGACAGGGAGC
TGGTTCACATGATCAACTGGGCGAAGAGGGTGCCAGTGACCGAAGCTGGCTTTGGTGCTGACATCGGAATGGAGAAATTCTTCAACATCA
AGTGCCGAGCTTCCGGCTTGGTGCCCAACGTGGTTGTGTTAGTGGCAACGGTGCGAGCTCTGAAGATGCATGGAGGCGGGCCAAGTGTAA
CGGCTGGTGTTCCTCTTAAGAAAGAATATACAGAGGAGAACATCCAGCTGGTGGCAGACGGCTGCTGTAACCTCCAGAAGCAAATTCAGA
TCACTCAGCTCTTTGGGGTTCCCGTTGTGGTGGCTCTGAATGTCTTCAAGACCGACACCCGCGCTGAGATTGACTTGGTGTGTGAGCTTG
CAAAGCGGGCTGGTGCCTTTGATGCAGTCCCCTGCTATCACTGGTCCGTTGGTGGAAAAGGATCGGTGGACTTGGCTCGGGCTGTGAGAG
AGGCTGCGAGTAAAAGAAGCCGATTCCAGTTCCTGTATGATGTTCAGGTTCCAATTGTGGACAAGATAAGGACCATTGCTCAGGCTGTCT
ATGGAGCCAAAGATATTGAACTCTCTCCTGAGGCACAAGCCAAAATAGATCGTTACACTCAACAGGGTTTTGGAAATTTGCCCATCTGCA
TGGCAAAGACCCACCTTTCTCTATCTCACCAACCTGACAAAAAAGGTGTGCCAAGGGACTTCATCTTACCTATCAGTGACGTCCGGGCCA
GCATAGGCGCTGGGTTCATTTACCCTTTGGTCGGAACGATGAGCACCATGCCAGGACTGCCCACCCGGCCCTGCTTTTATGACATAGATC
TTGATACCGAAACAGAACAAGTTAAAGGCTTGTTCTAAGTGGACAAGGCTCTCACAGGACCCGATGCAGACTCCTGAAACAGACTACTCT
TTGCCTTTTTGCTGCAGTTGGAGAAGAAACTGAATTTGAAAAATGTCTGTTATGCAATGCTGGAGACATGGTGAAATAGGCCAAAGATTT
CTTCTTCGTTCAAGATGAATTCTGTTCACAGTGGAGTATGGTGTTCGGCAAAAGGACCTCCACCAAGACTGAAAGAAACTAATTTATTTC
TGTTTCTGTGGAGTTTCCATTATTTCTACTGCTTACACTTTAGAATGTTTATTTTATGGGGACTAAGGGATTAGGAGTGTGAACTAAAAG

>27544_27544_2_ESR1-MTHFD1L_ESR1_chr6_152265643_ENST00000338799_MTHFD1L_chr6_151330955_ENST00000367321_length(amino acids)=635AA_BP=365
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFG
SNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK
ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQ
RDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINW
AKRVPVTEAGFGADIGMEKFFNIKCRASGLVPNVVVLVATVRALKMHGGGPSVTAGVPLKKEYTEENIQLVADGCCNLQKQIQITQLFGV
PVVVALNVFKTDTRAEIDLVCELAKRAGAFDAVPCYHWSVGGKGSVDLARAVREAASKRSRFQFLYDVQVPIVDKIRTIAQAVYGAKDIE
LSPEAQAKIDRYTQQGFGNLPICMAKTHLSLSHQPDKKGVPRDFILPISDVRASIGAGFIYPLVGTMSTMPGLPTRPCFYDIDLDTETEQ

--------------------------------------------------------------
>27544_27544_3_ESR1-MTHFD1L_ESR1_chr6_152265643_ENST00000427531_MTHFD1L_chr6_151330955_ENST00000367321_length(transcript)=2014nt_BP=809nt
GCTTAAAAATAATCTCCTGCCAGCCCAGTGACAAGCCTGTCCCACCCGGGGAGAATGCCCCGGAGTGGCGTGCGGGTCAGCCAGGGTCTG
CGCCTCGCAGCCACTGTGGAAGGAGCGCGGCCGGTCCAGGACACAGGAGACCACTTTGTGACTTCAATGGCGAAGGCCAAATTCAGATAA
TCGACGCCAGGGTGGCAGAGAAAGATTGGCCAGTACCAATGACAAGGGAAGTATGGCTATGGAATCTGCCAAGGAGACTCGCTACTGTGC
AGTGTGCAATGACTATGCTTCAGGCTACCATTATGGAGTCTGGTCCTGTGAGGGCTGCAAGGCCTTCTTCAAGAGAAGTATTCAAGGACA
TAACGACTATATGTGTCCAGCCACCAACCAGTGCACCATTGATAAAAACAGGAGGAAGAGCTGCCAGGCCTGCCGGCTCCGTAAATGCTA
CGAAGTGGGAATGATGAAAGGTGGGATACGAAAAGACCGAAGAGGAGGGAGAATGTTGAAACACAAGCGCCAGAGAGATGATGGGGAGGG
CAGGGGTGAAGTGGGGTCTGCTGGAGACATGAGAGCTGCCAACCTTTGGCCAAGCCCGCTCATGATCAAACGCTCTAAGAAGAACAGCCT
GGCCTTGTCCCTGACGGCCGACCAGATGGTCAGTGCCTTGTTGGATGCTGAGCCCCCGATACTCTATTCCGAGTATGATCCTACCAGACC
CTTCAGTGAAGCTTCGATGATGGGCTTACTGACCAACCTGGCAGACAGGGAGCTGGTTCACATGATCAACTGGGCGAAGAGGGTGCCAGT
GACCGAAGCTGGCTTTGGTGCTGACATCGGAATGGAGAAATTCTTCAACATCAAGTGCCGAGCTTCCGGCTTGGTGCCCAACGTGGTTGT
GTTAGTGGCAACGGTGCGAGCTCTGAAGATGCATGGAGGCGGGCCAAGTGTAACGGCTGGTGTTCCTCTTAAGAAAGAATATACAGAGGA
GAACATCCAGCTGGTGGCAGACGGCTGCTGTAACCTCCAGAAGCAAATTCAGATCACTCAGCTCTTTGGGGTTCCCGTTGTGGTGGCTCT
GAATGTCTTCAAGACCGACACCCGCGCTGAGATTGACTTGGTGTGTGAGCTTGCAAAGCGGGCTGGTGCCTTTGATGCAGTCCCCTGCTA
TCACTGGTCCGTTGGTGGAAAAGGATCGGTGGACTTGGCTCGGGCTGTGAGAGAGGCTGCGAGTAAAAGAAGCCGATTCCAGTTCCTGTA
TGATGTTCAGGTTCCAATTGTGGACAAGATAAGGACCATTGCTCAGGCTGTCTATGGAGCCAAAGATATTGAACTCTCTCCTGAGGCACA
AGCCAAAATAGATCGTTACACTCAACAGGGTTTTGGAAATTTGCCCATCTGCATGGCAAAGACCCACCTTTCTCTATCTCACCAACCTGA
CAAAAAAGGTGTGCCAAGGGACTTCATCTTACCTATCAGTGACGTCCGGGCCAGCATAGGCGCTGGGTTCATTTACCCTTTGGTCGGAAC
GATGAGCACCATGCCAGGACTGCCCACCCGGCCCTGCTTTTATGACATAGATCTTGATACCGAAACAGAACAAGTTAAAGGCTTGTTCTA
AGTGGACAAGGCTCTCACAGGACCCGATGCAGACTCCTGAAACAGACTACTCTTTGCCTTTTTGCTGCAGTTGGAGAAGAAACTGAATTT
GAAAAATGTCTGTTATGCAATGCTGGAGACATGGTGAAATAGGCCAAAGATTTCTTCTTCGTTCAAGATGAATTCTGTTCACAGTGGAGT
ATGGTGTTCGGCAAAAGGACCTCCACCAAGACTGAAAGAAACTAATTTATTTCTGTTTCTGTGGAGTTTCCATTATTTCTACTGCTTACA
CTTTAGAATGTTTATTTTATGGGGACTAAGGGATTAGGAGTGTGAACTAAAAGGTAACATTTTCCACTCTCAAGTTTTCTACTTTGTCTT

>27544_27544_3_ESR1-MTHFD1L_ESR1_chr6_152265643_ENST00000427531_MTHFD1L_chr6_151330955_ENST00000367321_length(amino acids)=471AA_BP=201
MASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGG
IRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMG
LLTNLADRELVHMINWAKRVPVTEAGFGADIGMEKFFNIKCRASGLVPNVVVLVATVRALKMHGGGPSVTAGVPLKKEYTEENIQLVADG
CCNLQKQIQITQLFGVPVVVALNVFKTDTRAEIDLVCELAKRAGAFDAVPCYHWSVGGKGSVDLARAVREAASKRSRFQFLYDVQVPIVD
KIRTIAQAVYGAKDIELSPEAQAKIDRYTQQGFGNLPICMAKTHLSLSHQPDKKGVPRDFILPISDVRASIGAGFIYPLVGTMSTMPGLP

--------------------------------------------------------------
>27544_27544_4_ESR1-MTHFD1L_ESR1_chr6_152265643_ENST00000440973_MTHFD1L_chr6_151330955_ENST00000367321_length(transcript)=2671nt_BP=1466nt
ATGGTCATAACAGCCTCCTGTCTACCGACTCAGAACGGATTTTACCAAAACTGAAAATGCAGGCTCCATGCTCAGAAGCTCTTTAACAGG
CTCGAAAGGTCCATGCTCCTTTCTCCTGCCCATTCTATAGCATAAGAAGACAGTCTCTGAGTGATAATCTTCTCTTCAAGAAGAAGAAAA
CTAGGAAGGAGTAAGCACAAAGATCTCTTCACATTCTCCGGGACTGCGGTACCAAATATCAGCACAGCACTTCTTGAAAAAGGATGTAGA
TTTTAATCTGAACTTTGAACCATCACTGAGGTGGCCCGCCGGTTTCTGAGCCTTCTGCCCTGCGGGGACACGGTCTGCACCCTGCCCGCG
GCCACGGACCATGACCATGACCCTCCACACCAAAGCATCTGGGATGGCCCTACTGCATCAGATCCAAGGGAACGAGCTGGAGCCCCTGAA
CCGTCCGCAGCTCAAGATCCCCCTGGAGCGGCCCCTGGGCGAGGTGTACCTGGACAGCAGCAAGCCCGCCGTGTACAACTACCCCGAGGG
CGCCGCCTACGAGTTCAACGCCGCGGCCGCCGCCAACGCGCAGGTCTACGGTCAGACCGGCCTCCCCTACGGCCCCGGGTCTGAGGCTGC
GGCGTTCGGCTCCAACGGCCTGGGGGGTTTCCCCCCACTCAACAGCGTGTCTCCGAGCCCGCTGATGCTACTGCACCCGCCGCCGCAGCT
GTCGCCTTTCCTGCAGCCCCACGGCCAGCAGGTGCCCTACTACCTGGAGAACGAGCCCAGCGGCTACACGGTGCGCGAGGCCGGCCCGCC
GGCATTCTACAGGCCAAATTCAGATAATCGACGCCAGGGTGGCAGAGAAAGATTGGCCAGTACCAATGACAAGGGAAGTATGGCTATGGA
ATCTGCCAAGGAGACTCGCTACTGTGCAGTGTGCAATGACTATGCTTCAGGCTACCATTATGGAGTCTGGTCCTGTGAGGGCTGCAAGGC
CTTCTTCAAGAGAAGTATTCAAGGACATAACGACTATATGTGTCCAGCCACCAACCAGTGCACCATTGATAAAAACAGGAGGAAGAGCTG
CCAGGCCTGCCGGCTCCGTAAATGCTACGAAGTGGGAATGATGAAAGGTGGGATACGAAAAGACCGAAGAGGAGGGAGAATGTTGAAACA
CAAGCGCCAGAGAGATGATGGGGAGGGCAGGGGTGAAGTGGGGTCTGCTGGAGACATGAGAGCTGCCAACCTTTGGCCAAGCCCGCTCAT
GATCAAACGCTCTAAGAAGAACAGCCTGGCCTTGTCCCTGACGGCCGACCAGATGGTCAGTGCCTTGTTGGATGCTGAGCCCCCGATACT
CTATTCCGAGTATGATCCTACCAGACCCTTCAGTGAAGCTTCGATGATGGGCTTACTGACCAACCTGGCAGACAGGGAGCTGGTTCACAT
GATCAACTGGGCGAAGAGGGTGCCAGTGACCGAAGCTGGCTTTGGTGCTGACATCGGAATGGAGAAATTCTTCAACATCAAGTGCCGAGC
TTCCGGCTTGGTGCCCAACGTGGTTGTGTTAGTGGCAACGGTGCGAGCTCTGAAGATGCATGGAGGCGGGCCAAGTGTAACGGCTGGTGT
TCCTCTTAAGAAAGAATATACAGAGGAGAACATCCAGCTGGTGGCAGACGGCTGCTGTAACCTCCAGAAGCAAATTCAGATCACTCAGCT
CTTTGGGGTTCCCGTTGTGGTGGCTCTGAATGTCTTCAAGACCGACACCCGCGCTGAGATTGACTTGGTGTGTGAGCTTGCAAAGCGGGC
TGGTGCCTTTGATGCAGTCCCCTGCTATCACTGGTCCGTTGGTGGAAAAGGATCGGTGGACTTGGCTCGGGCTGTGAGAGAGGCTGCGAG
TAAAAGAAGCCGATTCCAGTTCCTGTATGATGTTCAGGTTCCAATTGTGGACAAGATAAGGACCATTGCTCAGGCTGTCTATGGAGCCAA
AGATATTGAACTCTCTCCTGAGGCACAAGCCAAAATAGATCGTTACACTCAACAGGGTTTTGGAAATTTGCCCATCTGCATGGCAAAGAC
CCACCTTTCTCTATCTCACCAACCTGACAAAAAAGGTGTGCCAAGGGACTTCATCTTACCTATCAGTGACGTCCGGGCCAGCATAGGCGC
TGGGTTCATTTACCCTTTGGTCGGAACGATGAGCACCATGCCAGGACTGCCCACCCGGCCCTGCTTTTATGACATAGATCTTGATACCGA
AACAGAACAAGTTAAAGGCTTGTTCTAAGTGGACAAGGCTCTCACAGGACCCGATGCAGACTCCTGAAACAGACTACTCTTTGCCTTTTT
GCTGCAGTTGGAGAAGAAACTGAATTTGAAAAATGTCTGTTATGCAATGCTGGAGACATGGTGAAATAGGCCAAAGATTTCTTCTTCGTT
CAAGATGAATTCTGTTCACAGTGGAGTATGGTGTTCGGCAAAAGGACCTCCACCAAGACTGAAAGAAACTAATTTATTTCTGTTTCTGTG
GAGTTTCCATTATTTCTACTGCTTACACTTTAGAATGTTTATTTTATGGGGACTAAGGGATTAGGAGTGTGAACTAAAAGGTAACATTTT

>27544_27544_4_ESR1-MTHFD1L_ESR1_chr6_152265643_ENST00000440973_MTHFD1L_chr6_151330955_ENST00000367321_length(amino acids)=635AA_BP=365
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFG
SNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK
ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQ
RDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINW
AKRVPVTEAGFGADIGMEKFFNIKCRASGLVPNVVVLVATVRALKMHGGGPSVTAGVPLKKEYTEENIQLVADGCCNLQKQIQITQLFGV
PVVVALNVFKTDTRAEIDLVCELAKRAGAFDAVPCYHWSVGGKGSVDLARAVREAASKRSRFQFLYDVQVPIVDKIRTIAQAVYGAKDIE
LSPEAQAKIDRYTQQGFGNLPICMAKTHLSLSHQPDKKGVPRDFILPISDVRASIGAGFIYPLVGTMSTMPGLPTRPCFYDIDLDTETEQ

--------------------------------------------------------------
>27544_27544_5_ESR1-MTHFD1L_ESR1_chr6_152265643_ENST00000443427_MTHFD1L_chr6_151330955_ENST00000367321_length(transcript)=2562nt_BP=1357nt
GACAAACAGAGATATATCGGAGTCTGGCACGGGGCACATAAGGCAGCACATTAGAGAAAGCCGGCCCCTGGATCCGTCTTTCGCGTTTAT
TTTAAGCCCAGTCTTCCCTGGGCCACCTTTAGCAGATCCTCGTGCGCCCCCGCCCCCTGGCCGTGAAACTCAGCCTCTATCCAGCAGCGA
CGACAAGTAAAGTGGCCCGCCGGTTTCTGAGCCTTCTGCCCTGCGGGGACACGGTCTGCACCCTGCCCGCGGCCACGGACCATGACCATG
ACCCTCCACACCAAAGCATCTGGGATGGCCCTACTGCATCAGATCCAAGGGAACGAGCTGGAGCCCCTGAACCGTCCGCAGCTCAAGATC
CCCCTGGAGCGGCCCCTGGGCGAGGTGTACCTGGACAGCAGCAAGCCCGCCGTGTACAACTACCCCGAGGGCGCCGCCTACGAGTTCAAC
GCCGCGGCCGCCGCCAACGCGCAGGTCTACGGTCAGACCGGCCTCCCCTACGGCCCCGGGTCTGAGGCTGCGGCGTTCGGCTCCAACGGC
CTGGGGGGTTTCCCCCCACTCAACAGCGTGTCTCCGAGCCCGCTGATGCTACTGCACCCGCCGCCGCAGCTGTCGCCTTTCCTGCAGCCC
CACGGCCAGCAGGTGCCCTACTACCTGGAGAACGAGCCCAGCGGCTACACGGTGCGCGAGGCCGGCCCGCCGGCATTCTACAGGCCAAAT
TCAGATAATCGACGCCAGGGTGGCAGAGAAAGATTGGCCAGTACCAATGACAAGGGAAGTATGGCTATGGAATCTGCCAAGGAGACTCGC
TACTGTGCAGTGTGCAATGACTATGCTTCAGGCTACCATTATGGAGTCTGGTCCTGTGAGGGCTGCAAGGCCTTCTTCAAGAGAAGTATT
CAAGGACATAACGACTATATGTGTCCAGCCACCAACCAGTGCACCATTGATAAAAACAGGAGGAAGAGCTGCCAGGCCTGCCGGCTCCGT
AAATGCTACGAAGTGGGAATGATGAAAGGTGGGATACGAAAAGACCGAAGAGGAGGGAGAATGTTGAAACACAAGCGCCAGAGAGATGAT
GGGGAGGGCAGGGGTGAAGTGGGGTCTGCTGGAGACATGAGAGCTGCCAACCTTTGGCCAAGCCCGCTCATGATCAAACGCTCTAAGAAG
AACAGCCTGGCCTTGTCCCTGACGGCCGACCAGATGGTCAGTGCCTTGTTGGATGCTGAGCCCCCGATACTCTATTCCGAGTATGATCCT
ACCAGACCCTTCAGTGAAGCTTCGATGATGGGCTTACTGACCAACCTGGCAGACAGGGAGCTGGTTCACATGATCAACTGGGCGAAGAGG
GTGCCAGTGACCGAAGCTGGCTTTGGTGCTGACATCGGAATGGAGAAATTCTTCAACATCAAGTGCCGAGCTTCCGGCTTGGTGCCCAAC
GTGGTTGTGTTAGTGGCAACGGTGCGAGCTCTGAAGATGCATGGAGGCGGGCCAAGTGTAACGGCTGGTGTTCCTCTTAAGAAAGAATAT
ACAGAGGAGAACATCCAGCTGGTGGCAGACGGCTGCTGTAACCTCCAGAAGCAAATTCAGATCACTCAGCTCTTTGGGGTTCCCGTTGTG
GTGGCTCTGAATGTCTTCAAGACCGACACCCGCGCTGAGATTGACTTGGTGTGTGAGCTTGCAAAGCGGGCTGGTGCCTTTGATGCAGTC
CCCTGCTATCACTGGTCCGTTGGTGGAAAAGGATCGGTGGACTTGGCTCGGGCTGTGAGAGAGGCTGCGAGTAAAAGAAGCCGATTCCAG
TTCCTGTATGATGTTCAGGTTCCAATTGTGGACAAGATAAGGACCATTGCTCAGGCTGTCTATGGAGCCAAAGATATTGAACTCTCTCCT
GAGGCACAAGCCAAAATAGATCGTTACACTCAACAGGGTTTTGGAAATTTGCCCATCTGCATGGCAAAGACCCACCTTTCTCTATCTCAC
CAACCTGACAAAAAAGGTGTGCCAAGGGACTTCATCTTACCTATCAGTGACGTCCGGGCCAGCATAGGCGCTGGGTTCATTTACCCTTTG
GTCGGAACGATGAGCACCATGCCAGGACTGCCCACCCGGCCCTGCTTTTATGACATAGATCTTGATACCGAAACAGAACAAGTTAAAGGC
TTGTTCTAAGTGGACAAGGCTCTCACAGGACCCGATGCAGACTCCTGAAACAGACTACTCTTTGCCTTTTTGCTGCAGTTGGAGAAGAAA
CTGAATTTGAAAAATGTCTGTTATGCAATGCTGGAGACATGGTGAAATAGGCCAAAGATTTCTTCTTCGTTCAAGATGAATTCTGTTCAC
AGTGGAGTATGGTGTTCGGCAAAAGGACCTCCACCAAGACTGAAAGAAACTAATTTATTTCTGTTTCTGTGGAGTTTCCATTATTTCTAC
TGCTTACACTTTAGAATGTTTATTTTATGGGGACTAAGGGATTAGGAGTGTGAACTAAAAGGTAACATTTTCCACTCTCAAGTTTTCTAC

>27544_27544_5_ESR1-MTHFD1L_ESR1_chr6_152265643_ENST00000443427_MTHFD1L_chr6_151330955_ENST00000367321_length(amino acids)=635AA_BP=365
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFG
SNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK
ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQ
RDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINW
AKRVPVTEAGFGADIGMEKFFNIKCRASGLVPNVVVLVATVRALKMHGGGPSVTAGVPLKKEYTEENIQLVADGCCNLQKQIQITQLFGV
PVVVALNVFKTDTRAEIDLVCELAKRAGAFDAVPCYHWSVGGKGSVDLARAVREAASKRSRFQFLYDVQVPIVDKIRTIAQAVYGAKDIE
LSPEAQAKIDRYTQQGFGNLPICMAKTHLSLSHQPDKKGVPRDFILPISDVRASIGAGFIYPLVGTMSTMPGLPTRPCFYDIDLDTETEQ

--------------------------------------------------------------
>27544_27544_6_ESR1-MTHFD1L_ESR1_chr6_152382259_ENST00000206249_MTHFD1L_chr6_151330954_ENST00000367321_length(transcript)=2936nt_BP=1731nt
GAGTTGTGCCTGGAGTGATGTTTAAGCCAATGTCAGGGCAAGGCAACAGTCCCTGGCCGTCCTCCAGCACCTTTGTAATGCATATGAGCT
CGGGAGACCAGTACTTAAAGTTGGAGGCCCGGGAGCCCAGGAGCTGGCGGAGGGCGTTCGTCCTGGGACTGCACTTGCTCCCGTCGGGTC
GCCCGGCTTCACCGGACCCGCAGGCTCCCGGGGCAGGGCCGGGGCCAGAGCTCGCGTGTCGGCGGGACATGCGCTGCGTCGCCTCTAACC
TCGGGCTGTGCTCTTTTTCCAGGTGGCCCGCCGGTTTCTGAGCCTTCTGCCCTGCGGGGACACGGTCTGCACCCTGCCCGCGGCCACGGA
CCATGACCATGACCCTCCACACCAAAGCATCTGGGATGGCCCTACTGCATCAGATCCAAGGGAACGAGCTGGAGCCCCTGAACCGTCCGC
AGCTCAAGATCCCCCTGGAGCGGCCCCTGGGCGAGGTGTACCTGGACAGCAGCAAGCCCGCCGTGTACAACTACCCCGAGGGCGCCGCCT
ACGAGTTCAACGCCGCGGCCGCCGCCAACGCGCAGGTCTACGGTCAGACCGGCCTCCCCTACGGCCCCGGGTCTGAGGCTGCGGCGTTCG
GCTCCAACGGCCTGGGGGGTTTCCCCCCACTCAACAGCGTGTCTCCGAGCCCGCTGATGCTACTGCACCCGCCGCCGCAGCTGTCGCCTT
TCCTGCAGCCCCACGGCCAGCAGGTGCCCTACTACCTGGAGAACGAGCCCAGCGGCTACACGGTGCGCGAGGCCGGCCCGCCGGCATTCT
ACAGGCCAAATTCAGATAATCGACGCCAGGGTGGCAGAGAAAGATTGGCCAGTACCAATGACAAGGGAAGTATGGCTATGGAATCTGCCA
AGGAGACTCGCTACTGTGCAGTGTGCAATGACTATGCTTCAGGCTACCATTATGGAGTCTGGTCCTGTGAGGGCTGCAAGGCCTTCTTCA
AGAGAAGTATTCAAGGACATAACGACTATATGTGTCCAGCCACCAACCAGTGCACCATTGATAAAAACAGGAGGAAGAGCTGCCAGGCCT
GCCGGCTCCGTAAATGCTACGAAGTGGGAATGATGAAAGGTGGGATACGAAAAGACCGAAGAGGAGGGAGAATGTTGAAACACAAGCGCC
AGAGAGATGATGGGGAGGGCAGGGGTGAAGTGGGGTCTGCTGGAGACATGAGAGCTGCCAACCTTTGGCCAAGCCCGCTCATGATCAAAC
GCTCTAAGAAGAACAGCCTGGCCTTGTCCCTGACGGCCGACCAGATGGTCAGTGCCTTGTTGGATGCTGAGCCCCCGATACTCTATTCCG
AGTATGATCCTACCAGACCCTTCAGTGAAGCTTCGATGATGGGCTTACTGACCAACCTGGCAGACAGGGAGCTGGTTCACATGATCAACT
GGGCGAAGAGGGTGCCAGGCTTTGTGGATTTGACCCTCCATGATCAGGTCCACCTTCTAGAATGTGCCTGGCTAGAGATCCTGATGATTG
GTCTCGTCTGGCGCTCCATGGAGCACCCAGGGAAGCTACTGTTTGCTCCTAACTTGCTCTTGGACAGGAACCAGGGAAAATGTGTAGAGG
GCATGGTGGAGATCTTCGACATGCTGCTGGCTACATCATCTCGGTTCCGCATGATGAATCTGCAGGGAGAGGAGTTTGTGTGCCTCAAAT
CTATTATTTTGCTTAATTCTGTGACCGAAGCTGGCTTTGGTGCTGACATCGGAATGGAGAAATTCTTCAACATCAAGTGCCGAGCTTCCG
GCTTGGTGCCCAACGTGGTTGTGTTAGTGGCAACGGTGCGAGCTCTGAAGATGCATGGAGGCGGGCCAAGTGTAACGGCTGGTGTTCCTC
TTAAGAAAGAATATACAGAGGAGAACATCCAGCTGGTGGCAGACGGCTGCTGTAACCTCCAGAAGCAAATTCAGATCACTCAGCTCTTTG
GGGTTCCCGTTGTGGTGGCTCTGAATGTCTTCAAGACCGACACCCGCGCTGAGATTGACTTGGTGTGTGAGCTTGCAAAGCGGGCTGGTG
CCTTTGATGCAGTCCCCTGCTATCACTGGTCCGTTGGTGGAAAAGGATCGGTGGACTTGGCTCGGGCTGTGAGAGAGGCTGCGAGTAAAA
GAAGCCGATTCCAGTTCCTGTATGATGTTCAGGTTCCAATTGTGGACAAGATAAGGACCATTGCTCAGGCTGTCTATGGAGCCAAAGATA
TTGAACTCTCTCCTGAGGCACAAGCCAAAATAGATCGTTACACTCAACAGGGTTTTGGAAATTTGCCCATCTGCATGGCAAAGACCCACC
TTTCTCTATCTCACCAACCTGACAAAAAAGGTGTGCCAAGGGACTTCATCTTACCTATCAGTGACGTCCGGGCCAGCATAGGCGCTGGGT
TCATTTACCCTTTGGTCGGAACGATGAGCACCATGCCAGGACTGCCCACCCGGCCCTGCTTTTATGACATAGATCTTGATACCGAAACAG
AACAAGTTAAAGGCTTGTTCTAAGTGGACAAGGCTCTCACAGGACCCGATGCAGACTCCTGAAACAGACTACTCTTTGCCTTTTTGCTGC
AGTTGGAGAAGAAACTGAATTTGAAAAATGTCTGTTATGCAATGCTGGAGACATGGTGAAATAGGCCAAAGATTTCTTCTTCGTTCAAGA
TGAATTCTGTTCACAGTGGAGTATGGTGTTCGGCAAAAGGACCTCCACCAAGACTGAAAGAAACTAATTTATTTCTGTTTCTGTGGAGTT
TCCATTATTTCTACTGCTTACACTTTAGAATGTTTATTTTATGGGGACTAAGGGATTAGGAGTGTGAACTAAAAGGTAACATTTTCCACT

>27544_27544_6_ESR1-MTHFD1L_ESR1_chr6_152382259_ENST00000206249_MTHFD1L_chr6_151330954_ENST00000367321_length(amino acids)=726AA_BP=456
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFG
SNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK
ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQ
RDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINW
AKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKS
IILLNSVTEAGFGADIGMEKFFNIKCRASGLVPNVVVLVATVRALKMHGGGPSVTAGVPLKKEYTEENIQLVADGCCNLQKQIQITQLFG
VPVVVALNVFKTDTRAEIDLVCELAKRAGAFDAVPCYHWSVGGKGSVDLARAVREAASKRSRFQFLYDVQVPIVDKIRTIAQAVYGAKDI
ELSPEAQAKIDRYTQQGFGNLPICMAKTHLSLSHQPDKKGVPRDFILPISDVRASIGAGFIYPLVGTMSTMPGLPTRPCFYDIDLDTETE

--------------------------------------------------------------
>27544_27544_7_ESR1-MTHFD1L_ESR1_chr6_152382259_ENST00000338799_MTHFD1L_chr6_151330954_ENST00000367321_length(transcript)=4034nt_BP=2829nt
CTAGAGCATGGGTGGCCATTGTTGACCTACAGGAGGCACCACTGTCACCAACAAAGGGTAACAGTCTTTCTTTTCAATATTTATTTATAT
CCAGTATTTATTTTCAATACTGACTATGGAGAGAGCTCTCCTGTGCTCAAACACTGCAATACTGGGGGTCTTTCAAAGCACAAAAACATA
TATTTGCATGATGGCATCATTAACATTTTTATGGCTTTCTATTTCTTTTTTGTACTGGTCTCAAGAGCCACTCATAAATCTCTCAGTAAC
TGCATAGTGTCCCAGGGCCAGAGACCGGCCACTCCTGGCATTGTGATTAGAGTCATTTAATATCCAAGGTGGTGACTAATGTCTGGCAAC
AAAGCCTCCATTGGGTGTCATGTGTCCTGGGACCCTGAGCGTGGGCACTCTAGGAGCACCTCAGTATTGCGTGTTAGTACTATGGCCGAG
AGAATAGTTGAGAAAGTGGTCAAGAGGTGGATCCATGTGAACGCCACTGGGAAATGAGAGACCTCGTTCCCAATCACGGTCAGTGCAACT
CGAAAGCCTAAAATCAGTTTAAAACAAAGGTATCTACCTTTATCTTATGTTCATATCCTAGGCTTTTAATAATACGTATTTTTCACATGT
TTACAGAAAGCAGTCAACTGAGCTATTCATGGAAAGGTTTGTGGGTTTGGTTAACGAAGTGGAGGAGTATTACATTTCAGCTGGAAACAC
ATCCCTAGAATGCCAAAACATTTATTCCAAAGTCTGGTTTCCTGGTGCAATCGGAGGCATGGCAATGCCTCTGTTCAGAGACTGGGGGCT
AGGGCCAGTAAGGCATTTGATCCACATGTATCCCAGAAGGCTTTTATTGTTAAATTATATTCTTTCGGAAAAACCACCCATGTCCTATTT
TGTAAACTTGATATCCATACACTTTTGACTGGCATTCTATTTTAGCCGTAAGACTATGATTCACAGCAAGCCTGTTTTTCCTCTTGCTTG
GGGTGGCAGCAGAAAGCATAGGGTACTTTCCAGCCTCCAAGGGTAGGGGCAAAGGGGCTGGGGTTTCTCCTCCCCAGTACAGCTTTCTCT
GGCTGTGCCACACTGCTCCCTGTGAGCAGACAGCAAGTCTCCCCTCACTCCCCACTGCCATTCATCCAGCGCTGTGCAGTAGCCCAGCTG
CGTGTCTGCCGGGAGGGGCTGCCAAGTGCCCTGCCTACTGGCTGCTTCCCGAATCCCTGCCATTCCACGCACAAACACATCCACACACTC
TCTCTGCCTAGTTCACACACTGAGCCACTCGCACATGCGAGCACATTCCTTCCTTCCTTCTCACTCTCTCGGCCCTTGACTTCTACAAGC
CCATGGAACATTTCTGGAAAGACGTTCTTGATCCAGCAGGGTGGCCCGCCGGTTTCTGAGCCTTCTGCCCTGCGGGGACACGGTCTGCAC
CCTGCCCGCGGCCACGGACCATGACCATGACCCTCCACACCAAAGCATCTGGGATGGCCCTACTGCATCAGATCCAAGGGAACGAGCTGG
AGCCCCTGAACCGTCCGCAGCTCAAGATCCCCCTGGAGCGGCCCCTGGGCGAGGTGTACCTGGACAGCAGCAAGCCCGCCGTGTACAACT
ACCCCGAGGGCGCCGCCTACGAGTTCAACGCCGCGGCCGCCGCCAACGCGCAGGTCTACGGTCAGACCGGCCTCCCCTACGGCCCCGGGT
CTGAGGCTGCGGCGTTCGGCTCCAACGGCCTGGGGGGTTTCCCCCCACTCAACAGCGTGTCTCCGAGCCCGCTGATGCTACTGCACCCGC
CGCCGCAGCTGTCGCCTTTCCTGCAGCCCCACGGCCAGCAGGTGCCCTACTACCTGGAGAACGAGCCCAGCGGCTACACGGTGCGCGAGG
CCGGCCCGCCGGCATTCTACAGGCCAAATTCAGATAATCGACGCCAGGGTGGCAGAGAAAGATTGGCCAGTACCAATGACAAGGGAAGTA
TGGCTATGGAATCTGCCAAGGAGACTCGCTACTGTGCAGTGTGCAATGACTATGCTTCAGGCTACCATTATGGAGTCTGGTCCTGTGAGG
GCTGCAAGGCCTTCTTCAAGAGAAGTATTCAAGGACATAACGACTATATGTGTCCAGCCACCAACCAGTGCACCATTGATAAAAACAGGA
GGAAGAGCTGCCAGGCCTGCCGGCTCCGTAAATGCTACGAAGTGGGAATGATGAAAGGTGGGATACGAAAAGACCGAAGAGGAGGGAGAA
TGTTGAAACACAAGCGCCAGAGAGATGATGGGGAGGGCAGGGGTGAAGTGGGGTCTGCTGGAGACATGAGAGCTGCCAACCTTTGGCCAA
GCCCGCTCATGATCAAACGCTCTAAGAAGAACAGCCTGGCCTTGTCCCTGACGGCCGACCAGATGGTCAGTGCCTTGTTGGATGCTGAGC
CCCCGATACTCTATTCCGAGTATGATCCTACCAGACCCTTCAGTGAAGCTTCGATGATGGGCTTACTGACCAACCTGGCAGACAGGGAGC
TGGTTCACATGATCAACTGGGCGAAGAGGGTGCCAGGCTTTGTGGATTTGACCCTCCATGATCAGGTCCACCTTCTAGAATGTGCCTGGC
TAGAGATCCTGATGATTGGTCTCGTCTGGCGCTCCATGGAGCACCCAGGGAAGCTACTGTTTGCTCCTAACTTGCTCTTGGACAGGAACC
AGGGAAAATGTGTAGAGGGCATGGTGGAGATCTTCGACATGCTGCTGGCTACATCATCTCGGTTCCGCATGATGAATCTGCAGGGAGAGG
AGTTTGTGTGCCTCAAATCTATTATTTTGCTTAATTCTGTGACCGAAGCTGGCTTTGGTGCTGACATCGGAATGGAGAAATTCTTCAACA
TCAAGTGCCGAGCTTCCGGCTTGGTGCCCAACGTGGTTGTGTTAGTGGCAACGGTGCGAGCTCTGAAGATGCATGGAGGCGGGCCAAGTG
TAACGGCTGGTGTTCCTCTTAAGAAAGAATATACAGAGGAGAACATCCAGCTGGTGGCAGACGGCTGCTGTAACCTCCAGAAGCAAATTC
AGATCACTCAGCTCTTTGGGGTTCCCGTTGTGGTGGCTCTGAATGTCTTCAAGACCGACACCCGCGCTGAGATTGACTTGGTGTGTGAGC
TTGCAAAGCGGGCTGGTGCCTTTGATGCAGTCCCCTGCTATCACTGGTCCGTTGGTGGAAAAGGATCGGTGGACTTGGCTCGGGCTGTGA
GAGAGGCTGCGAGTAAAAGAAGCCGATTCCAGTTCCTGTATGATGTTCAGGTTCCAATTGTGGACAAGATAAGGACCATTGCTCAGGCTG
TCTATGGAGCCAAAGATATTGAACTCTCTCCTGAGGCACAAGCCAAAATAGATCGTTACACTCAACAGGGTTTTGGAAATTTGCCCATCT
GCATGGCAAAGACCCACCTTTCTCTATCTCACCAACCTGACAAAAAAGGTGTGCCAAGGGACTTCATCTTACCTATCAGTGACGTCCGGG
CCAGCATAGGCGCTGGGTTCATTTACCCTTTGGTCGGAACGATGAGCACCATGCCAGGACTGCCCACCCGGCCCTGCTTTTATGACATAG
ATCTTGATACCGAAACAGAACAAGTTAAAGGCTTGTTCTAAGTGGACAAGGCTCTCACAGGACCCGATGCAGACTCCTGAAACAGACTAC
TCTTTGCCTTTTTGCTGCAGTTGGAGAAGAAACTGAATTTGAAAAATGTCTGTTATGCAATGCTGGAGACATGGTGAAATAGGCCAAAGA
TTTCTTCTTCGTTCAAGATGAATTCTGTTCACAGTGGAGTATGGTGTTCGGCAAAAGGACCTCCACCAAGACTGAAAGAAACTAATTTAT
TTCTGTTTCTGTGGAGTTTCCATTATTTCTACTGCTTACACTTTAGAATGTTTATTTTATGGGGACTAAGGGATTAGGAGTGTGAACTAA

>27544_27544_7_ESR1-MTHFD1L_ESR1_chr6_152382259_ENST00000338799_MTHFD1L_chr6_151330954_ENST00000367321_length(amino acids)=726AA_BP=456
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFG
SNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK
ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQ
RDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINW
AKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKS
IILLNSVTEAGFGADIGMEKFFNIKCRASGLVPNVVVLVATVRALKMHGGGPSVTAGVPLKKEYTEENIQLVADGCCNLQKQIQITQLFG
VPVVVALNVFKTDTRAEIDLVCELAKRAGAFDAVPCYHWSVGGKGSVDLARAVREAASKRSRFQFLYDVQVPIVDKIRTIAQAVYGAKDI
ELSPEAQAKIDRYTQQGFGNLPICMAKTHLSLSHQPDKKGVPRDFILPISDVRASIGAGFIYPLVGTMSTMPGLPTRPCFYDIDLDTETE

--------------------------------------------------------------
>27544_27544_8_ESR1-MTHFD1L_ESR1_chr6_152382259_ENST00000406599_MTHFD1L_chr6_151330954_ENST00000367321_length(transcript)=2025nt_BP=820nt
AGGAGCTGGCGGAGGGCGTTCGTCCTGGGACTGCACTTGCTCCCGTCGGGTCGCCCGGCTTCACCGGACCCGCAGGCTCCCGGGGCAGGG
CCGGGGCCAGAGCTCGCGTGTCGGCGGGACATGCGCTGCGTCGCCTCTAACCTCGGGCTGTGCTCTTTTTCCAGGTGGCCCGCCGGTTTC
TGAGCCTTCTGCCCTGCGGGGACACGGTCTGCACCCTGCCCGCGGCCACGGACCATGACCATGACCCTCCACACCAAAGCATCTGGGATG
GCCCTACTGCATCAGATCCAAGGGAACGAGCTGGAGCCCCTGAACCGTCCGCAGCTCAAGATCCCCCTGGAGCGGCCCCTGGGCGAGGTG
TACCTGGACAGCAGCAAGCCCGCCGTGTACAACTACCCCGAGGGCGCCGCCTACGAGTTCAACGCCGCGGCCGCCGCCAACGCGCAGGTC
TACGGTCAGACCGGCCTCCCCTACGGCCCCGGGTCTGAGGCTGCGGCGTTCGGCTCCAACGGCCTGGGGGGTTTCCCCCCACTCAACAGC
GTGTCTCCGAGCCCGCTGATGCTACTGCACCCGCCGCCGCAGCTGTCGCCTTTCCTGCAGCCCCACGGCCAGCAGGTGCCCTACTACCTG
GAGAACGAGCCCAGCGGCTACACGGTGCGCGAGGCCGGCCCGCCGGCATTCTACAGGAACCAGGGAAAATGTGTAGAGGGCATGGTGGAG
ATCTTCGACATGCTGCTGGCTACATCATCTCGGTTCCGCATGATGAATCTGCAGGGAGAGGAGTTTGTGTGCCTCAAATCTATTATTTTG
CTTAATTCTGTGACCGAAGCTGGCTTTGGTGCTGACATCGGAATGGAGAAATTCTTCAACATCAAGTGCCGAGCTTCCGGCTTGGTGCCC
AACGTGGTTGTGTTAGTGGCAACGGTGCGAGCTCTGAAGATGCATGGAGGCGGGCCAAGTGTAACGGCTGGTGTTCCTCTTAAGAAAGAA
TATACAGAGGAGAACATCCAGCTGGTGGCAGACGGCTGCTGTAACCTCCAGAAGCAAATTCAGATCACTCAGCTCTTTGGGGTTCCCGTT
GTGGTGGCTCTGAATGTCTTCAAGACCGACACCCGCGCTGAGATTGACTTGGTGTGTGAGCTTGCAAAGCGGGCTGGTGCCTTTGATGCA
GTCCCCTGCTATCACTGGTCCGTTGGTGGAAAAGGATCGGTGGACTTGGCTCGGGCTGTGAGAGAGGCTGCGAGTAAAAGAAGCCGATTC
CAGTTCCTGTATGATGTTCAGGTTCCAATTGTGGACAAGATAAGGACCATTGCTCAGGCTGTCTATGGAGCCAAAGATATTGAACTCTCT
CCTGAGGCACAAGCCAAAATAGATCGTTACACTCAACAGGGTTTTGGAAATTTGCCCATCTGCATGGCAAAGACCCACCTTTCTCTATCT
CACCAACCTGACAAAAAAGGTGTGCCAAGGGACTTCATCTTACCTATCAGTGACGTCCGGGCCAGCATAGGCGCTGGGTTCATTTACCCT
TTGGTCGGAACGATGAGCACCATGCCAGGACTGCCCACCCGGCCCTGCTTTTATGACATAGATCTTGATACCGAAACAGAACAAGTTAAA
GGCTTGTTCTAAGTGGACAAGGCTCTCACAGGACCCGATGCAGACTCCTGAAACAGACTACTCTTTGCCTTTTTGCTGCAGTTGGAGAAG
AAACTGAATTTGAAAAATGTCTGTTATGCAATGCTGGAGACATGGTGAAATAGGCCAAAGATTTCTTCTTCGTTCAAGATGAATTCTGTT
CACAGTGGAGTATGGTGTTCGGCAAAAGGACCTCCACCAAGACTGAAAGAAACTAATTTATTTCTGTTTCTGTGGAGTTTCCATTATTTC
TACTGCTTACACTTTAGAATGTTTATTTTATGGGGACTAAGGGATTAGGAGTGTGAACTAAAAGGTAACATTTTCCACTCTCAAGTTTTC

>27544_27544_8_ESR1-MTHFD1L_ESR1_chr6_152382259_ENST00000406599_MTHFD1L_chr6_151330954_ENST00000367321_length(amino acids)=465AA_BP=195
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFG
SNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRNQGKCVEGMVEIFDMLLATSSRFRMMNLQ
GEEFVCLKSIILLNSVTEAGFGADIGMEKFFNIKCRASGLVPNVVVLVATVRALKMHGGGPSVTAGVPLKKEYTEENIQLVADGCCNLQK
QIQITQLFGVPVVVALNVFKTDTRAEIDLVCELAKRAGAFDAVPCYHWSVGGKGSVDLARAVREAASKRSRFQFLYDVQVPIVDKIRTIA
QAVYGAKDIELSPEAQAKIDRYTQQGFGNLPICMAKTHLSLSHQPDKKGVPRDFILPISDVRASIGAGFIYPLVGTMSTMPGLPTRPCFY

--------------------------------------------------------------
>27544_27544_9_ESR1-MTHFD1L_ESR1_chr6_152382259_ENST00000427531_MTHFD1L_chr6_151330954_ENST00000367321_length(transcript)=2287nt_BP=1082nt
GCTTAAAAATAATCTCCTGCCAGCCCAGTGACAAGCCTGTCCCACCCGGGGAGAATGCCCCGGAGTGGCGTGCGGGTCAGCCAGGGTCTG
CGCCTCGCAGCCACTGTGGAAGGAGCGCGGCCGGTCCAGGACACAGGAGACCACTTTGTGACTTCAATGGCGAAGGCCAAATTCAGATAA
TCGACGCCAGGGTGGCAGAGAAAGATTGGCCAGTACCAATGACAAGGGAAGTATGGCTATGGAATCTGCCAAGGAGACTCGCTACTGTGC
AGTGTGCAATGACTATGCTTCAGGCTACCATTATGGAGTCTGGTCCTGTGAGGGCTGCAAGGCCTTCTTCAAGAGAAGTATTCAAGGACA
TAACGACTATATGTGTCCAGCCACCAACCAGTGCACCATTGATAAAAACAGGAGGAAGAGCTGCCAGGCCTGCCGGCTCCGTAAATGCTA
CGAAGTGGGAATGATGAAAGGTGGGATACGAAAAGACCGAAGAGGAGGGAGAATGTTGAAACACAAGCGCCAGAGAGATGATGGGGAGGG
CAGGGGTGAAGTGGGGTCTGCTGGAGACATGAGAGCTGCCAACCTTTGGCCAAGCCCGCTCATGATCAAACGCTCTAAGAAGAACAGCCT
GGCCTTGTCCCTGACGGCCGACCAGATGGTCAGTGCCTTGTTGGATGCTGAGCCCCCGATACTCTATTCCGAGTATGATCCTACCAGACC
CTTCAGTGAAGCTTCGATGATGGGCTTACTGACCAACCTGGCAGACAGGGAGCTGGTTCACATGATCAACTGGGCGAAGAGGGTGCCAGG
CTTTGTGGATTTGACCCTCCATGATCAGGTCCACCTTCTAGAATGTGCCTGGCTAGAGATCCTGATGATTGGTCTCGTCTGGCGCTCCAT
GGAGCACCCAGGGAAGCTACTGTTTGCTCCTAACTTGCTCTTGGACAGGAACCAGGGAAAATGTGTAGAGGGCATGGTGGAGATCTTCGA
CATGCTGCTGGCTACATCATCTCGGTTCCGCATGATGAATCTGCAGGGAGAGGAGTTTGTGTGCCTCAAATCTATTATTTTGCTTAATTC
TGTGACCGAAGCTGGCTTTGGTGCTGACATCGGAATGGAGAAATTCTTCAACATCAAGTGCCGAGCTTCCGGCTTGGTGCCCAACGTGGT
TGTGTTAGTGGCAACGGTGCGAGCTCTGAAGATGCATGGAGGCGGGCCAAGTGTAACGGCTGGTGTTCCTCTTAAGAAAGAATATACAGA
GGAGAACATCCAGCTGGTGGCAGACGGCTGCTGTAACCTCCAGAAGCAAATTCAGATCACTCAGCTCTTTGGGGTTCCCGTTGTGGTGGC
TCTGAATGTCTTCAAGACCGACACCCGCGCTGAGATTGACTTGGTGTGTGAGCTTGCAAAGCGGGCTGGTGCCTTTGATGCAGTCCCCTG
CTATCACTGGTCCGTTGGTGGAAAAGGATCGGTGGACTTGGCTCGGGCTGTGAGAGAGGCTGCGAGTAAAAGAAGCCGATTCCAGTTCCT
GTATGATGTTCAGGTTCCAATTGTGGACAAGATAAGGACCATTGCTCAGGCTGTCTATGGAGCCAAAGATATTGAACTCTCTCCTGAGGC
ACAAGCCAAAATAGATCGTTACACTCAACAGGGTTTTGGAAATTTGCCCATCTGCATGGCAAAGACCCACCTTTCTCTATCTCACCAACC
TGACAAAAAAGGTGTGCCAAGGGACTTCATCTTACCTATCAGTGACGTCCGGGCCAGCATAGGCGCTGGGTTCATTTACCCTTTGGTCGG
AACGATGAGCACCATGCCAGGACTGCCCACCCGGCCCTGCTTTTATGACATAGATCTTGATACCGAAACAGAACAAGTTAAAGGCTTGTT
CTAAGTGGACAAGGCTCTCACAGGACCCGATGCAGACTCCTGAAACAGACTACTCTTTGCCTTTTTGCTGCAGTTGGAGAAGAAACTGAA
TTTGAAAAATGTCTGTTATGCAATGCTGGAGACATGGTGAAATAGGCCAAAGATTTCTTCTTCGTTCAAGATGAATTCTGTTCACAGTGG
AGTATGGTGTTCGGCAAAAGGACCTCCACCAAGACTGAAAGAAACTAATTTATTTCTGTTTCTGTGGAGTTTCCATTATTTCTACTGCTT
ACACTTTAGAATGTTTATTTTATGGGGACTAAGGGATTAGGAGTGTGAACTAAAAGGTAACATTTTCCACTCTCAAGTTTTCTACTTTGT

>27544_27544_9_ESR1-MTHFD1L_ESR1_chr6_152382259_ENST00000427531_MTHFD1L_chr6_151330954_ENST00000367321_length(amino acids)=562AA_BP=292
MASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGG
IRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMG
LLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSR
FRMMNLQGEEFVCLKSIILLNSVTEAGFGADIGMEKFFNIKCRASGLVPNVVVLVATVRALKMHGGGPSVTAGVPLKKEYTEENIQLVAD
GCCNLQKQIQITQLFGVPVVVALNVFKTDTRAEIDLVCELAKRAGAFDAVPCYHWSVGGKGSVDLARAVREAASKRSRFQFLYDVQVPIV
DKIRTIAQAVYGAKDIELSPEAQAKIDRYTQQGFGNLPICMAKTHLSLSHQPDKKGVPRDFILPISDVRASIGAGFIYPLVGTMSTMPGL

--------------------------------------------------------------
>27544_27544_10_ESR1-MTHFD1L_ESR1_chr6_152382259_ENST00000440973_MTHFD1L_chr6_151330954_ENST00000367321_length(transcript)=2944nt_BP=1739nt
ATGGTCATAACAGCCTCCTGTCTACCGACTCAGAACGGATTTTACCAAAACTGAAAATGCAGGCTCCATGCTCAGAAGCTCTTTAACAGG
CTCGAAAGGTCCATGCTCCTTTCTCCTGCCCATTCTATAGCATAAGAAGACAGTCTCTGAGTGATAATCTTCTCTTCAAGAAGAAGAAAA
CTAGGAAGGAGTAAGCACAAAGATCTCTTCACATTCTCCGGGACTGCGGTACCAAATATCAGCACAGCACTTCTTGAAAAAGGATGTAGA
TTTTAATCTGAACTTTGAACCATCACTGAGGTGGCCCGCCGGTTTCTGAGCCTTCTGCCCTGCGGGGACACGGTCTGCACCCTGCCCGCG
GCCACGGACCATGACCATGACCCTCCACACCAAAGCATCTGGGATGGCCCTACTGCATCAGATCCAAGGGAACGAGCTGGAGCCCCTGAA
CCGTCCGCAGCTCAAGATCCCCCTGGAGCGGCCCCTGGGCGAGGTGTACCTGGACAGCAGCAAGCCCGCCGTGTACAACTACCCCGAGGG
CGCCGCCTACGAGTTCAACGCCGCGGCCGCCGCCAACGCGCAGGTCTACGGTCAGACCGGCCTCCCCTACGGCCCCGGGTCTGAGGCTGC
GGCGTTCGGCTCCAACGGCCTGGGGGGTTTCCCCCCACTCAACAGCGTGTCTCCGAGCCCGCTGATGCTACTGCACCCGCCGCCGCAGCT
GTCGCCTTTCCTGCAGCCCCACGGCCAGCAGGTGCCCTACTACCTGGAGAACGAGCCCAGCGGCTACACGGTGCGCGAGGCCGGCCCGCC
GGCATTCTACAGGCCAAATTCAGATAATCGACGCCAGGGTGGCAGAGAAAGATTGGCCAGTACCAATGACAAGGGAAGTATGGCTATGGA
ATCTGCCAAGGAGACTCGCTACTGTGCAGTGTGCAATGACTATGCTTCAGGCTACCATTATGGAGTCTGGTCCTGTGAGGGCTGCAAGGC
CTTCTTCAAGAGAAGTATTCAAGGACATAACGACTATATGTGTCCAGCCACCAACCAGTGCACCATTGATAAAAACAGGAGGAAGAGCTG
CCAGGCCTGCCGGCTCCGTAAATGCTACGAAGTGGGAATGATGAAAGGTGGGATACGAAAAGACCGAAGAGGAGGGAGAATGTTGAAACA
CAAGCGCCAGAGAGATGATGGGGAGGGCAGGGGTGAAGTGGGGTCTGCTGGAGACATGAGAGCTGCCAACCTTTGGCCAAGCCCGCTCAT
GATCAAACGCTCTAAGAAGAACAGCCTGGCCTTGTCCCTGACGGCCGACCAGATGGTCAGTGCCTTGTTGGATGCTGAGCCCCCGATACT
CTATTCCGAGTATGATCCTACCAGACCCTTCAGTGAAGCTTCGATGATGGGCTTACTGACCAACCTGGCAGACAGGGAGCTGGTTCACAT
GATCAACTGGGCGAAGAGGGTGCCAGGCTTTGTGGATTTGACCCTCCATGATCAGGTCCACCTTCTAGAATGTGCCTGGCTAGAGATCCT
GATGATTGGTCTCGTCTGGCGCTCCATGGAGCACCCAGGGAAGCTACTGTTTGCTCCTAACTTGCTCTTGGACAGGAACCAGGGAAAATG
TGTAGAGGGCATGGTGGAGATCTTCGACATGCTGCTGGCTACATCATCTCGGTTCCGCATGATGAATCTGCAGGGAGAGGAGTTTGTGTG
CCTCAAATCTATTATTTTGCTTAATTCTGTGACCGAAGCTGGCTTTGGTGCTGACATCGGAATGGAGAAATTCTTCAACATCAAGTGCCG
AGCTTCCGGCTTGGTGCCCAACGTGGTTGTGTTAGTGGCAACGGTGCGAGCTCTGAAGATGCATGGAGGCGGGCCAAGTGTAACGGCTGG
TGTTCCTCTTAAGAAAGAATATACAGAGGAGAACATCCAGCTGGTGGCAGACGGCTGCTGTAACCTCCAGAAGCAAATTCAGATCACTCA
GCTCTTTGGGGTTCCCGTTGTGGTGGCTCTGAATGTCTTCAAGACCGACACCCGCGCTGAGATTGACTTGGTGTGTGAGCTTGCAAAGCG
GGCTGGTGCCTTTGATGCAGTCCCCTGCTATCACTGGTCCGTTGGTGGAAAAGGATCGGTGGACTTGGCTCGGGCTGTGAGAGAGGCTGC
GAGTAAAAGAAGCCGATTCCAGTTCCTGTATGATGTTCAGGTTCCAATTGTGGACAAGATAAGGACCATTGCTCAGGCTGTCTATGGAGC
CAAAGATATTGAACTCTCTCCTGAGGCACAAGCCAAAATAGATCGTTACACTCAACAGGGTTTTGGAAATTTGCCCATCTGCATGGCAAA
GACCCACCTTTCTCTATCTCACCAACCTGACAAAAAAGGTGTGCCAAGGGACTTCATCTTACCTATCAGTGACGTCCGGGCCAGCATAGG
CGCTGGGTTCATTTACCCTTTGGTCGGAACGATGAGCACCATGCCAGGACTGCCCACCCGGCCCTGCTTTTATGACATAGATCTTGATAC
CGAAACAGAACAAGTTAAAGGCTTGTTCTAAGTGGACAAGGCTCTCACAGGACCCGATGCAGACTCCTGAAACAGACTACTCTTTGCCTT
TTTGCTGCAGTTGGAGAAGAAACTGAATTTGAAAAATGTCTGTTATGCAATGCTGGAGACATGGTGAAATAGGCCAAAGATTTCTTCTTC
GTTCAAGATGAATTCTGTTCACAGTGGAGTATGGTGTTCGGCAAAAGGACCTCCACCAAGACTGAAAGAAACTAATTTATTTCTGTTTCT
GTGGAGTTTCCATTATTTCTACTGCTTACACTTTAGAATGTTTATTTTATGGGGACTAAGGGATTAGGAGTGTGAACTAAAAGGTAACAT

>27544_27544_10_ESR1-MTHFD1L_ESR1_chr6_152382259_ENST00000440973_MTHFD1L_chr6_151330954_ENST00000367321_length(amino acids)=726AA_BP=456
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFG
SNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK
ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQ
RDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINW
AKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKS
IILLNSVTEAGFGADIGMEKFFNIKCRASGLVPNVVVLVATVRALKMHGGGPSVTAGVPLKKEYTEENIQLVADGCCNLQKQIQITQLFG
VPVVVALNVFKTDTRAEIDLVCELAKRAGAFDAVPCYHWSVGGKGSVDLARAVREAASKRSRFQFLYDVQVPIVDKIRTIAQAVYGAKDI
ELSPEAQAKIDRYTQQGFGNLPICMAKTHLSLSHQPDKKGVPRDFILPISDVRASIGAGFIYPLVGTMSTMPGLPTRPCFYDIDLDTETE

--------------------------------------------------------------
>27544_27544_11_ESR1-MTHFD1L_ESR1_chr6_152382259_ENST00000443427_MTHFD1L_chr6_151330954_ENST00000367321_length(transcript)=2835nt_BP=1630nt
GACAAACAGAGATATATCGGAGTCTGGCACGGGGCACATAAGGCAGCACATTAGAGAAAGCCGGCCCCTGGATCCGTCTTTCGCGTTTAT
TTTAAGCCCAGTCTTCCCTGGGCCACCTTTAGCAGATCCTCGTGCGCCCCCGCCCCCTGGCCGTGAAACTCAGCCTCTATCCAGCAGCGA
CGACAAGTAAAGTGGCCCGCCGGTTTCTGAGCCTTCTGCCCTGCGGGGACACGGTCTGCACCCTGCCCGCGGCCACGGACCATGACCATG
ACCCTCCACACCAAAGCATCTGGGATGGCCCTACTGCATCAGATCCAAGGGAACGAGCTGGAGCCCCTGAACCGTCCGCAGCTCAAGATC
CCCCTGGAGCGGCCCCTGGGCGAGGTGTACCTGGACAGCAGCAAGCCCGCCGTGTACAACTACCCCGAGGGCGCCGCCTACGAGTTCAAC
GCCGCGGCCGCCGCCAACGCGCAGGTCTACGGTCAGACCGGCCTCCCCTACGGCCCCGGGTCTGAGGCTGCGGCGTTCGGCTCCAACGGC
CTGGGGGGTTTCCCCCCACTCAACAGCGTGTCTCCGAGCCCGCTGATGCTACTGCACCCGCCGCCGCAGCTGTCGCCTTTCCTGCAGCCC
CACGGCCAGCAGGTGCCCTACTACCTGGAGAACGAGCCCAGCGGCTACACGGTGCGCGAGGCCGGCCCGCCGGCATTCTACAGGCCAAAT
TCAGATAATCGACGCCAGGGTGGCAGAGAAAGATTGGCCAGTACCAATGACAAGGGAAGTATGGCTATGGAATCTGCCAAGGAGACTCGC
TACTGTGCAGTGTGCAATGACTATGCTTCAGGCTACCATTATGGAGTCTGGTCCTGTGAGGGCTGCAAGGCCTTCTTCAAGAGAAGTATT
CAAGGACATAACGACTATATGTGTCCAGCCACCAACCAGTGCACCATTGATAAAAACAGGAGGAAGAGCTGCCAGGCCTGCCGGCTCCGT
AAATGCTACGAAGTGGGAATGATGAAAGGTGGGATACGAAAAGACCGAAGAGGAGGGAGAATGTTGAAACACAAGCGCCAGAGAGATGAT
GGGGAGGGCAGGGGTGAAGTGGGGTCTGCTGGAGACATGAGAGCTGCCAACCTTTGGCCAAGCCCGCTCATGATCAAACGCTCTAAGAAG
AACAGCCTGGCCTTGTCCCTGACGGCCGACCAGATGGTCAGTGCCTTGTTGGATGCTGAGCCCCCGATACTCTATTCCGAGTATGATCCT
ACCAGACCCTTCAGTGAAGCTTCGATGATGGGCTTACTGACCAACCTGGCAGACAGGGAGCTGGTTCACATGATCAACTGGGCGAAGAGG
GTGCCAGGCTTTGTGGATTTGACCCTCCATGATCAGGTCCACCTTCTAGAATGTGCCTGGCTAGAGATCCTGATGATTGGTCTCGTCTGG
CGCTCCATGGAGCACCCAGGGAAGCTACTGTTTGCTCCTAACTTGCTCTTGGACAGGAACCAGGGAAAATGTGTAGAGGGCATGGTGGAG
ATCTTCGACATGCTGCTGGCTACATCATCTCGGTTCCGCATGATGAATCTGCAGGGAGAGGAGTTTGTGTGCCTCAAATCTATTATTTTG
CTTAATTCTGTGACCGAAGCTGGCTTTGGTGCTGACATCGGAATGGAGAAATTCTTCAACATCAAGTGCCGAGCTTCCGGCTTGGTGCCC
AACGTGGTTGTGTTAGTGGCAACGGTGCGAGCTCTGAAGATGCATGGAGGCGGGCCAAGTGTAACGGCTGGTGTTCCTCTTAAGAAAGAA
TATACAGAGGAGAACATCCAGCTGGTGGCAGACGGCTGCTGTAACCTCCAGAAGCAAATTCAGATCACTCAGCTCTTTGGGGTTCCCGTT
GTGGTGGCTCTGAATGTCTTCAAGACCGACACCCGCGCTGAGATTGACTTGGTGTGTGAGCTTGCAAAGCGGGCTGGTGCCTTTGATGCA
GTCCCCTGCTATCACTGGTCCGTTGGTGGAAAAGGATCGGTGGACTTGGCTCGGGCTGTGAGAGAGGCTGCGAGTAAAAGAAGCCGATTC
CAGTTCCTGTATGATGTTCAGGTTCCAATTGTGGACAAGATAAGGACCATTGCTCAGGCTGTCTATGGAGCCAAAGATATTGAACTCTCT
CCTGAGGCACAAGCCAAAATAGATCGTTACACTCAACAGGGTTTTGGAAATTTGCCCATCTGCATGGCAAAGACCCACCTTTCTCTATCT
CACCAACCTGACAAAAAAGGTGTGCCAAGGGACTTCATCTTACCTATCAGTGACGTCCGGGCCAGCATAGGCGCTGGGTTCATTTACCCT
TTGGTCGGAACGATGAGCACCATGCCAGGACTGCCCACCCGGCCCTGCTTTTATGACATAGATCTTGATACCGAAACAGAACAAGTTAAA
GGCTTGTTCTAAGTGGACAAGGCTCTCACAGGACCCGATGCAGACTCCTGAAACAGACTACTCTTTGCCTTTTTGCTGCAGTTGGAGAAG
AAACTGAATTTGAAAAATGTCTGTTATGCAATGCTGGAGACATGGTGAAATAGGCCAAAGATTTCTTCTTCGTTCAAGATGAATTCTGTT
CACAGTGGAGTATGGTGTTCGGCAAAAGGACCTCCACCAAGACTGAAAGAAACTAATTTATTTCTGTTTCTGTGGAGTTTCCATTATTTC
TACTGCTTACACTTTAGAATGTTTATTTTATGGGGACTAAGGGATTAGGAGTGTGAACTAAAAGGTAACATTTTCCACTCTCAAGTTTTC

>27544_27544_11_ESR1-MTHFD1L_ESR1_chr6_152382259_ENST00000443427_MTHFD1L_chr6_151330954_ENST00000367321_length(amino acids)=726AA_BP=456
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFG
SNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK
ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQ
RDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINW
AKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKS
IILLNSVTEAGFGADIGMEKFFNIKCRASGLVPNVVVLVATVRALKMHGGGPSVTAGVPLKKEYTEENIQLVADGCCNLQKQIQITQLFG
VPVVVALNVFKTDTRAEIDLVCELAKRAGAFDAVPCYHWSVGGKGSVDLARAVREAASKRSRFQFLYDVQVPIVDKIRTIAQAVYGAKDI
ELSPEAQAKIDRYTQQGFGNLPICMAKTHLSLSHQPDKKGVPRDFILPISDVRASIGAGFIYPLVGTMSTMPGLPTRPCFYDIDLDTETE

--------------------------------------------------------------
>27544_27544_12_ESR1-MTHFD1L_ESR1_chr6_152382259_ENST00000456483_MTHFD1L_chr6_151330954_ENST00000367321_length(transcript)=2456nt_BP=1251nt
AAACACATCCACACACTCTCTCTGCCTAGTTCACACACTGAGCCACTCGCACATGCGAGCACATTCCTTCCTTCCTTCTCACTCTCTCGG
CCCTTGACTTCTACAAGCCCATGGAACATTTCTGGAAAGACGTTCTTGATCCAGCAGGGTGGCCCGCCGGTTTCTGAGCCTTCTGCCCTG
CGGGGACACGGTCTGCACCCTGCCCGCGGCCACGGACCATGACCATGACCCTCCACACCAAAGCATCTGGGATGGCCCTACTGCATCAGA
TCCAAGGGAACGAGCTGGAGCCCCTGAACCGTCCGCAGCTCAAGATCCCCCTGGAGCGGCCCCTGGGCGAGGTGTACCTGGACAGCAGCA
AGCCCGCCGTGTACAACTACCCCGAGGGCGCCGCCTACGAGTTCAACGCCGCGGCCGCCGCCAACGCGCAGGTCTACGGTCAGACCGGCC
TCCCCTACGGCCCCGGGTCTGAGGCTGCGGCGTTCGGCTCCAACGGCCTGGGGGGTTTCCCCCCACTCAACAGCGTGTCTCCGAGCCCGC
TGATGCTACTGCACCCGCCGCCGCAGCTGTCGCCTTTCCTGCAGCCCCACGGCCAGCAGGTGCCCTACTACCTGGAGAACGAGCCCAGCG
GCTACACGGTGCGCGAGGCCGGCCCGCCGGCATTCTACAGGCCAAATTCAGATAATCGACGCCAGGGTGGCAGAGAAAGATTGGCCAGTA
CCAATGACAAGGGAAGTATGGCTATGGAATCTGCCAAGGAGACTCGCTACTGTGCAGTGTGCAATGACTATGCTTCAGGCTACCATTATG
GAGTCTGGTCCTGTGAGGGCTGCAAGGCCTTCTTCAAGAGAAGTATTCAAGGACATAACGACTATATGTGTCCAGCCACCAACCAGTGCA
CCATTGATAAAAACAGGAGGAAGAGCTGCCAGGCCTGCCGGCTCCGTAAATGCTACGAAGTGGGAATGATGAAAGGTGGCTTTGTGGATT
TGACCCTCCATGATCAGGTCCACCTTCTAGAATGTGCCTGGCTAGAGATCCTGATGATTGGTCTCGTCTGGCGCTCCATGGAGCACCCAG
GGAAGCTACTGTTTGCTCCTAACTTGCTCTTGGACAGGAACCAGGGAAAATGTGTAGAGGGCATGGTGGAGATCTTCGACATGCTGCTGG
CTACATCATCTCGGTTCCGCATGATGAATCTGCAGGGAGAGGAGTTTGTGTGCCTCAAATCTATTATTTTGCTTAATTCTGTGACCGAAG
CTGGCTTTGGTGCTGACATCGGAATGGAGAAATTCTTCAACATCAAGTGCCGAGCTTCCGGCTTGGTGCCCAACGTGGTTGTGTTAGTGG
CAACGGTGCGAGCTCTGAAGATGCATGGAGGCGGGCCAAGTGTAACGGCTGGTGTTCCTCTTAAGAAAGAATATACAGAGGAGAACATCC
AGCTGGTGGCAGACGGCTGCTGTAACCTCCAGAAGCAAATTCAGATCACTCAGCTCTTTGGGGTTCCCGTTGTGGTGGCTCTGAATGTCT
TCAAGACCGACACCCGCGCTGAGATTGACTTGGTGTGTGAGCTTGCAAAGCGGGCTGGTGCCTTTGATGCAGTCCCCTGCTATCACTGGT
CCGTTGGTGGAAAAGGATCGGTGGACTTGGCTCGGGCTGTGAGAGAGGCTGCGAGTAAAAGAAGCCGATTCCAGTTCCTGTATGATGTTC
AGGTTCCAATTGTGGACAAGATAAGGACCATTGCTCAGGCTGTCTATGGAGCCAAAGATATTGAACTCTCTCCTGAGGCACAAGCCAAAA
TAGATCGTTACACTCAACAGGGTTTTGGAAATTTGCCCATCTGCATGGCAAAGACCCACCTTTCTCTATCTCACCAACCTGACAAAAAAG
GTGTGCCAAGGGACTTCATCTTACCTATCAGTGACGTCCGGGCCAGCATAGGCGCTGGGTTCATTTACCCTTTGGTCGGAACGATGAGCA
CCATGCCAGGACTGCCCACCCGGCCCTGCTTTTATGACATAGATCTTGATACCGAAACAGAACAAGTTAAAGGCTTGTTCTAAGTGGACA
AGGCTCTCACAGGACCCGATGCAGACTCCTGAAACAGACTACTCTTTGCCTTTTTGCTGCAGTTGGAGAAGAAACTGAATTTGAAAAATG
TCTGTTATGCAATGCTGGAGACATGGTGAAATAGGCCAAAGATTTCTTCTTCGTTCAAGATGAATTCTGTTCACAGTGGAGTATGGTGTT
CGGCAAAAGGACCTCCACCAAGACTGAAAGAAACTAATTTATTTCTGTTTCTGTGGAGTTTCCATTATTTCTACTGCTTACACTTTAGAA
TGTTTATTTTATGGGGACTAAGGGATTAGGAGTGTGAACTAAAAGGTAACATTTTCCACTCTCAAGTTTTCTACTTTGTCTTTGAACTGA

>27544_27544_12_ESR1-MTHFD1L_ESR1_chr6_152382259_ENST00000456483_MTHFD1L_chr6_151330954_ENST00000367321_length(amino acids)=614AA_BP=344
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFG
SNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK
ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGFVDLTLHDQVHLLECA
WLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSVTEAGFGADIGMEKFF
NIKCRASGLVPNVVVLVATVRALKMHGGGPSVTAGVPLKKEYTEENIQLVADGCCNLQKQIQITQLFGVPVVVALNVFKTDTRAEIDLVC
ELAKRAGAFDAVPCYHWSVGGKGSVDLARAVREAASKRSRFQFLYDVQVPIVDKIRTIAQAVYGAKDIELSPEAQAKIDRYTQQGFGNLP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ESR1-MTHFD1L


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneESR1chr6:152265643chr6:151330955ENST00000206249+4835_174365.3333333333333596.0DDX5%3B self-association
HgeneESR1chr6:152265643chr6:151330955ENST00000338799+5935_174365.3333333333333596.0DDX5%3B self-association
HgeneESR1chr6:152265643chr6:151330955ENST00000440973+61035_174365.3333333333333596.0DDX5%3B self-association
HgeneESR1chr6:152265643chr6:151330955ENST00000443427+5935_174365.3333333333333596.0DDX5%3B self-association
HgeneESR1chr6:152382259chr6:151330954ENST00000206249+6835_174456.3333333333333596.0DDX5%3B self-association
HgeneESR1chr6:152382259chr6:151330954ENST00000338799+7935_174456.3333333333333596.0DDX5%3B self-association
HgeneESR1chr6:152382259chr6:151330954ENST00000440973+81035_174456.3333333333333596.0DDX5%3B self-association
HgeneESR1chr6:152382259chr6:151330954ENST00000443427+7935_174456.3333333333333596.0DDX5%3B self-association
HgeneESR1chr6:152382259chr6:151330954ENST00000456483+6835_174344.3333333333333484.0DDX5%3B self-association


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneESR1chr6:152265643chr6:151330955ENST00000206249+48262_595365.3333333333333596.0AKAP13
HgeneESR1chr6:152265643chr6:151330955ENST00000338799+59262_595365.3333333333333596.0AKAP13
HgeneESR1chr6:152265643chr6:151330955ENST00000440973+610262_595365.3333333333333596.0AKAP13
HgeneESR1chr6:152265643chr6:151330955ENST00000443427+59262_595365.3333333333333596.0AKAP13
HgeneESR1chr6:152265643chr6:151330955ENST00000456483+18262_5950484.0AKAP13
HgeneESR1chr6:152382259chr6:151330954ENST00000206249+68262_595456.3333333333333596.0AKAP13
HgeneESR1chr6:152382259chr6:151330954ENST00000338799+79262_595456.3333333333333596.0AKAP13
HgeneESR1chr6:152382259chr6:151330954ENST00000440973+810262_595456.3333333333333596.0AKAP13
HgeneESR1chr6:152382259chr6:151330954ENST00000443427+79262_595456.3333333333333596.0AKAP13
HgeneESR1chr6:152382259chr6:151330954ENST00000456483+68262_595344.3333333333333484.0AKAP13
HgeneESR1chr6:152265643chr6:151330955ENST00000456483+1835_1740484.0DDX5%3B self-association


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ESR1-MTHFD1L


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ESR1-MTHFD1L


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource