Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ESR2-SCARB1 (FusionGDB2 ID:27558)

Fusion Gene Summary for ESR2-SCARB1

Fusion gene summary

Fusion gene information	Fusion gene name: ESR2-SCARB1
	Fusion gene ID: 27558
		Hgene	Tgene
	Gene symbol	ESR2	SCARB1
	Gene ID	2100	949
	Gene name	estrogen receptor 2	scavenger receptor class B member 1
	Synonyms	ER-BETA\|ESR-BETA\|ESRB\|ESTRB\|Erb\|NR3A2\|ODG8	CD36L1\|CLA-1\|CLA1\|HDLQTL6\|SR-BI\|SRB1
	Cytomap	14q23.2-q23.3	12q24.31
	Type of gene	protein-coding	protein-coding
	Description	estrogen receptor betaestrogen receptor beta 4estrogen receptor beta splice variant, ERbeta2delta7estrogen receptor beta splice variant, ERbeta4delta7estrogen receptor beta splice variant, ERbeta6estrogen receptor beta splice variant, ERbeta6delta7e	scavenger receptor class B member 1CD36 and LIMPII analogous 1CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 1scavenger receptor class B type III
	Modification date	20200322	20200313
	UniProtAcc	Q92731	.
	Ensembl transtripts involved in fusion gene	ENST00000267525, ENST00000341099, ENST00000353772, ENST00000357782, ENST00000358599, ENST00000542956, ENST00000553796, ENST00000554572, ENST00000555278, ENST00000555483, ENST00000557772,	ENST00000261693, ENST00000339570, ENST00000376788, ENST00000415380, ENST00000535005, ENST00000540495, ENST00000541205, ENST00000544327, ENST00000546215,
Fusion gene scores	* DoF score	1 X 1 X 1=1	6 X 11 X 10=660
	# samples	1	18
	** MAII score	log2(1/1*10)=3.32192809488736	log2(18/660*10)=-1.87446911791614 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ESR2 [Title/Abstract] AND SCARB1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ESR2(64694132)-SCARB1(125308400), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ESR2	GO:0000122	negative regulation of transcription by RNA polymerase II	15345745
Hgene	ESR2	GO:0045893	positive regulation of transcription, DNA-templated	20074560
Hgene	ESR2	GO:0051091	positive regulation of DNA-binding transcription factor activity	10681512
Tgene	SCARB1	GO:0010886	positive regulation of cholesterol storage	9211901
Tgene	SCARB1	GO:0015920	lipopolysaccharide transport	12651854
Tgene	SCARB1	GO:0032497	detection of lipopolysaccharide	12651854
Tgene	SCARB1	GO:0034384	high-density lipoprotein particle clearance	9211901
Tgene	SCARB1	GO:0043654	recognition of apoptotic cell	9211901
Tgene	SCARB1	GO:0051000	positive regulation of nitric-oxide synthase activity	11792700

Fusion gene breakpoints across ESR2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SCARB1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	AF051428	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+

Top

Fusion Gene ORF analysis for ESR2-SCARB1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000267525	ENST00000261693	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000267525	ENST00000339570	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000267525	ENST00000376788	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000267525	ENST00000415380	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000267525	ENST00000535005	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000267525	ENST00000540495	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000267525	ENST00000541205	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000267525	ENST00000544327	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000267525	ENST00000546215	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000341099	ENST00000261693	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000341099	ENST00000339570	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000341099	ENST00000376788	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000341099	ENST00000415380	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000341099	ENST00000535005	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000341099	ENST00000540495	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000341099	ENST00000541205	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000341099	ENST00000544327	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000341099	ENST00000546215	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000353772	ENST00000261693	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000353772	ENST00000339570	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000353772	ENST00000376788	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000353772	ENST00000415380	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000353772	ENST00000535005	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000353772	ENST00000540495	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000353772	ENST00000541205	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000353772	ENST00000544327	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000353772	ENST00000546215	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000357782	ENST00000261693	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000357782	ENST00000339570	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000357782	ENST00000376788	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000357782	ENST00000415380	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000357782	ENST00000535005	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000357782	ENST00000540495	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000357782	ENST00000541205	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000357782	ENST00000544327	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000357782	ENST00000546215	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000358599	ENST00000261693	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000358599	ENST00000339570	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000358599	ENST00000376788	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000358599	ENST00000415380	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000358599	ENST00000535005	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000358599	ENST00000540495	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000358599	ENST00000541205	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000358599	ENST00000544327	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000358599	ENST00000546215	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000542956	ENST00000261693	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000542956	ENST00000339570	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000542956	ENST00000376788	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000542956	ENST00000415380	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000542956	ENST00000535005	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000542956	ENST00000540495	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000542956	ENST00000541205	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000542956	ENST00000544327	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000542956	ENST00000546215	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000553796	ENST00000261693	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000553796	ENST00000339570	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000553796	ENST00000376788	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000553796	ENST00000415380	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000553796	ENST00000535005	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000553796	ENST00000540495	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000553796	ENST00000541205	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000553796	ENST00000544327	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000553796	ENST00000546215	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000554572	ENST00000261693	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000554572	ENST00000339570	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000554572	ENST00000376788	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000554572	ENST00000415380	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000554572	ENST00000535005	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000554572	ENST00000540495	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000554572	ENST00000541205	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000554572	ENST00000544327	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000554572	ENST00000546215	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000555278	ENST00000261693	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000555278	ENST00000339570	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000555278	ENST00000376788	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000555278	ENST00000415380	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000555278	ENST00000535005	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000555278	ENST00000540495	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000555278	ENST00000541205	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000555278	ENST00000544327	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000555278	ENST00000546215	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000555483	ENST00000261693	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000555483	ENST00000339570	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000555483	ENST00000376788	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000555483	ENST00000415380	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000555483	ENST00000535005	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000555483	ENST00000540495	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000555483	ENST00000541205	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000555483	ENST00000544327	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000555483	ENST00000546215	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000557772	ENST00000261693	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000557772	ENST00000339570	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000557772	ENST00000376788	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000557772	ENST00000415380	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000557772	ENST00000535005	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000557772	ENST00000540495	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000557772	ENST00000541205	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000557772	ENST00000544327	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+
intron-intron	ENST00000557772	ENST00000546215	ESR2	chr14	64694132	-	SCARB1	chr12	125308400	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

Top

Fusion Genomic Features for ESR2-SCARB1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for ESR2-SCARB1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:64694132/:125308400)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ESR2 Q92731	.
FUNCTION: Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner (PubMed:20074560). Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual. {ECO:0000269\|PubMed:20074560, ECO:0000269\|PubMed:29261182, ECO:0000269\|PubMed:30113650}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Top

Fusion Gene Sequence for ESR2-SCARB1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for ESR2-SCARB1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for ESR2-SCARB1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for ESR2-SCARB1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source