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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ESRRG-DLD (FusionGDB2 ID:27590)

Fusion Gene Summary for ESRRG-DLD

check button Fusion gene summary
Fusion gene informationFusion gene name: ESRRG-DLD
Fusion gene ID: 27590
HgeneTgene
Gene symbol

ESRRG

DLD

Gene ID

2104

197257

Gene nameestrogen related receptor gammalactate dehydrogenase D
SynonymsERR-gamma|ERR3|ERRg|ERRgamma|NR3B3DLACD|DLD
Cytomap

1q41

16q23.1

Type of geneprotein-codingprotein-coding
Descriptionestrogen-related receptor gammaERR gamma-2estrogen receptor-related protein 3nuclear receptor subfamily 3 group B member 3probable D-lactate dehydrogenase, mitochondrialD-lactate dehydrogenase
Modification date2020031320200313
UniProtAcc

P62508

P09622

Ensembl transtripts involved in fusion geneENST00000359162, ENST00000360012, 
ENST00000361395, ENST00000361525, 
ENST00000366937, ENST00000366938, 
ENST00000366940, ENST00000391890, 
ENST00000408911, ENST00000463665, 
ENST00000471371, ENST00000487276, 
ENST00000493603, ENST00000493748, 
ENST00000205402, ENST00000437604, 
ENST00000440410, ENST00000537148, 
ENST00000494441, 
Fusion gene scores* DoF score6 X 6 X 2=723 X 3 X 2=18
# samples 63
** MAII scorelog2(6/72*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ESRRG [Title/Abstract] AND DLD [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointESRRG(217309111)-DLD(107531641), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneESRRG

GO:0006355

regulation of transcription, DNA-templated

23836911


check buttonFusion gene breakpoints across ESRRG (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across DLD (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ACD656888ESRRGchr1

217309111

-DLDchr7

107531641

+


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Fusion Gene ORF analysis for ESRRG-DLD

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000359162ENST00000205402ESRRGchr1

217309111

-DLDchr7

107531641

+
intron-5UTRENST00000359162ENST00000437604ESRRGchr1

217309111

-DLDchr7

107531641

+
intron-5UTRENST00000359162ENST00000440410ESRRGchr1

217309111

-DLDchr7

107531641

+
intron-5UTRENST00000359162ENST00000537148ESRRGchr1

217309111

-DLDchr7

107531641

+
intron-5UTRENST00000360012ENST00000205402ESRRGchr1

217309111

-DLDchr7

107531641

+
intron-5UTRENST00000360012ENST00000437604ESRRGchr1

217309111

-DLDchr7

107531641

+
intron-5UTRENST00000360012ENST00000440410ESRRGchr1

217309111

-DLDchr7

107531641

+
intron-5UTRENST00000360012ENST00000537148ESRRGchr1

217309111

-DLDchr7

107531641

+
intron-5UTRENST00000361395ENST00000205402ESRRGchr1

217309111

-DLDchr7

107531641

+
intron-5UTRENST00000361395ENST00000437604ESRRGchr1

217309111

-DLDchr7

107531641

+
intron-5UTRENST00000361395ENST00000440410ESRRGchr1

217309111

-DLDchr7

107531641

+
intron-5UTRENST00000361395ENST00000537148ESRRGchr1

217309111

-DLDchr7

107531641

+
intron-5UTRENST00000361525ENST00000205402ESRRGchr1

217309111

-DLDchr7

107531641

+
intron-5UTRENST00000361525ENST00000437604ESRRGchr1

217309111

-DLDchr7

107531641

+
intron-5UTRENST00000361525ENST00000440410ESRRGchr1

217309111

-DLDchr7

107531641

+
intron-5UTRENST00000361525ENST00000537148ESRRGchr1

217309111

-DLDchr7

107531641

+
intron-5UTRENST00000366937ENST00000205402ESRRGchr1

217309111

-DLDchr7

107531641

+
intron-5UTRENST00000366937ENST00000437604ESRRGchr1

217309111

-DLDchr7

107531641

+
intron-5UTRENST00000366937ENST00000440410ESRRGchr1

217309111

-DLDchr7

107531641

+
intron-5UTRENST00000366937ENST00000537148ESRRGchr1

217309111

-DLDchr7

107531641

+
intron-5UTRENST00000366938ENST00000205402ESRRGchr1

217309111

-DLDchr7

107531641

+
intron-5UTRENST00000366938ENST00000437604ESRRGchr1

217309111

-DLDchr7

107531641

+
intron-5UTRENST00000366938ENST00000440410ESRRGchr1

217309111

-DLDchr7

107531641

+
intron-5UTRENST00000366938ENST00000537148ESRRGchr1

217309111

-DLDchr7

107531641

+
intron-5UTRENST00000366940ENST00000205402ESRRGchr1

217309111

-DLDchr7

107531641

+
intron-5UTRENST00000366940ENST00000437604ESRRGchr1

217309111

-DLDchr7

107531641

+
intron-5UTRENST00000366940ENST00000440410ESRRGchr1

217309111

-DLDchr7

107531641

+
intron-5UTRENST00000366940ENST00000537148ESRRGchr1

217309111

-DLDchr7

107531641

+
intron-5UTRENST00000391890ENST00000205402ESRRGchr1

217309111

-DLDchr7

107531641

+
intron-5UTRENST00000391890ENST00000437604ESRRGchr1

217309111

-DLDchr7

107531641

+
intron-5UTRENST00000391890ENST00000440410ESRRGchr1

217309111

-DLDchr7

107531641

+
intron-5UTRENST00000391890ENST00000537148ESRRGchr1

217309111

-DLDchr7

107531641

+
intron-5UTRENST00000408911ENST00000205402ESRRGchr1

217309111

-DLDchr7

107531641

+
intron-5UTRENST00000408911ENST00000437604ESRRGchr1

217309111

-DLDchr7

107531641

+
intron-5UTRENST00000408911ENST00000440410ESRRGchr1

217309111

-DLDchr7

107531641

+
intron-5UTRENST00000408911ENST00000537148ESRRGchr1

217309111

-DLDchr7

107531641

+
intron-5UTRENST00000463665ENST00000205402ESRRGchr1

217309111

-DLDchr7

107531641

+
intron-5UTRENST00000463665ENST00000437604ESRRGchr1

217309111

-DLDchr7

107531641

+
intron-5UTRENST00000463665ENST00000440410ESRRGchr1

217309111

-DLDchr7

107531641

+
intron-5UTRENST00000463665ENST00000537148ESRRGchr1

217309111

-DLDchr7

107531641

+
intron-5UTRENST00000471371ENST00000205402ESRRGchr1

217309111

-DLDchr7

107531641

+
intron-5UTRENST00000471371ENST00000437604ESRRGchr1

217309111

-DLDchr7

107531641

+
intron-5UTRENST00000471371ENST00000440410ESRRGchr1

217309111

-DLDchr7

107531641

+
intron-5UTRENST00000471371ENST00000537148ESRRGchr1

217309111

-DLDchr7

107531641

+
intron-5UTRENST00000487276ENST00000205402ESRRGchr1

217309111

-DLDchr7

107531641

+
intron-5UTRENST00000487276ENST00000437604ESRRGchr1

217309111

-DLDchr7

107531641

+
intron-5UTRENST00000487276ENST00000440410ESRRGchr1

217309111

-DLDchr7

107531641

+
intron-5UTRENST00000487276ENST00000537148ESRRGchr1

217309111

-DLDchr7

107531641

+
intron-5UTRENST00000493603ENST00000205402ESRRGchr1

217309111

-DLDchr7

107531641

+
intron-5UTRENST00000493603ENST00000437604ESRRGchr1

217309111

-DLDchr7

107531641

+
intron-5UTRENST00000493603ENST00000440410ESRRGchr1

217309111

-DLDchr7

107531641

+
intron-5UTRENST00000493603ENST00000537148ESRRGchr1

217309111

-DLDchr7

107531641

+
intron-5UTRENST00000493748ENST00000205402ESRRGchr1

217309111

-DLDchr7

107531641

+
intron-5UTRENST00000493748ENST00000437604ESRRGchr1

217309111

-DLDchr7

107531641

+
intron-5UTRENST00000493748ENST00000440410ESRRGchr1

217309111

-DLDchr7

107531641

+
intron-5UTRENST00000493748ENST00000537148ESRRGchr1

217309111

-DLDchr7

107531641

+
intron-intronENST00000359162ENST00000494441ESRRGchr1

217309111

-DLDchr7

107531641

+
intron-intronENST00000360012ENST00000494441ESRRGchr1

217309111

-DLDchr7

107531641

+
intron-intronENST00000361395ENST00000494441ESRRGchr1

217309111

-DLDchr7

107531641

+
intron-intronENST00000361525ENST00000494441ESRRGchr1

217309111

-DLDchr7

107531641

+
intron-intronENST00000366937ENST00000494441ESRRGchr1

217309111

-DLDchr7

107531641

+
intron-intronENST00000366938ENST00000494441ESRRGchr1

217309111

-DLDchr7

107531641

+
intron-intronENST00000366940ENST00000494441ESRRGchr1

217309111

-DLDchr7

107531641

+
intron-intronENST00000391890ENST00000494441ESRRGchr1

217309111

-DLDchr7

107531641

+
intron-intronENST00000408911ENST00000494441ESRRGchr1

217309111

-DLDchr7

107531641

+
intron-intronENST00000463665ENST00000494441ESRRGchr1

217309111

-DLDchr7

107531641

+
intron-intronENST00000471371ENST00000494441ESRRGchr1

217309111

-DLDchr7

107531641

+
intron-intronENST00000487276ENST00000494441ESRRGchr1

217309111

-DLDchr7

107531641

+
intron-intronENST00000493603ENST00000494441ESRRGchr1

217309111

-DLDchr7

107531641

+
intron-intronENST00000493748ENST00000494441ESRRGchr1

217309111

-DLDchr7

107531641

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ESRRG-DLD


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ESRRG-DLD


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:217309111/:107531641)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ESRRG

P62508

DLD

P09622

FUNCTION: Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements (By similarity). Induces the expression of PERM1 in the skeletal muscle. {ECO:0000250, ECO:0000269|PubMed:11864604, ECO:0000269|PubMed:18063693, ECO:0000269|PubMed:19067653, ECO:0000269|PubMed:23836911}.FUNCTION: Lipoamide dehydrogenase is a component of the glycine cleavage system as well as an E3 component of three alpha-ketoacid dehydrogenase complexes (pyruvate-, alpha-ketoglutarate-, and branched-chain amino acid-dehydrogenase complex) (PubMed:15712224, PubMed:16442803, PubMed:16770810, PubMed:17404228, PubMed:20160912, PubMed:20385101). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion (PubMed:29211711). A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A (PubMed:29211711). In monomeric form may have additional moonlighting function as serine protease (PubMed:17404228). Involved in the hyperactivation of spermatazoa during capacitation and in the spermatazoal acrosome reaction (By similarity). {ECO:0000250|UniProtKB:Q811C4, ECO:0000269|PubMed:15712224, ECO:0000269|PubMed:16442803, ECO:0000269|PubMed:16770810, ECO:0000269|PubMed:17404228, ECO:0000269|PubMed:20160912, ECO:0000269|PubMed:20385101, ECO:0000269|PubMed:29211711}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ESRRG-DLD


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ESRRG-DLD


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ESRRG-DLD


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ESRRG-DLD


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource