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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ESYT2-CNTNAP2 (FusionGDB2 ID:27600)

Fusion Gene Summary for ESYT2-CNTNAP2

Fusion gene summary

Fusion gene information	Fusion gene name: ESYT2-CNTNAP2
	Fusion gene ID: 27600
		Hgene	Tgene
	Gene symbol	ESYT2	CNTNAP2
	Gene ID	57488	26047
	Gene name	extended synaptotagmin 2	contactin associated protein 2
	Synonyms	CHR2SYT\|E-Syt2\|FAM62B	AUTS15\|CASPR2\|CDFE\|NRXN4\|PTHSL1
	Cytomap	7q36.3	7q35-q36.1
	Type of gene	protein-coding	protein-coding
	Description	extended synaptotagmin-2chr2 synaptotagminextended synaptotagmin like protein 2extended synaptotagmin protein 2family with sequence similarity 62 (C2 domain containing), member B	contactin-associated protein-like 2cell recognition molecule Caspr2contactin associated protein like 2homolog of Drosophila neurexin IV
	Modification date	20200313	20200313
	UniProtAcc	A0FGR8	Q9UHC6
	Ensembl transtripts involved in fusion gene	ENST00000251527, ENST00000435514, ENST00000497111,	ENST00000463592, ENST00000538075, ENST00000361727,
Fusion gene scores	* DoF score	13 X 11 X 10=1430	30 X 34 X 9=9180
	# samples	16	36
	** MAII score	log2(16/1430*10)=-3.15987133677839 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(36/9180*10)=-4.6724253419715 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ESYT2 [Title/Abstract] AND CNTNAP2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ESYT2(158540885)-CNTNAP2(146740999), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across ESYT2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CNTNAP2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	HNSC	TCGA-CV-5444-01A	ESYT2	chr7	158540885	-	CNTNAP2	chr7	146740999	+

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Fusion Gene ORF analysis for ESYT2-CNTNAP2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000251527	ENST00000463592	ESYT2	chr7	158540885	-	CNTNAP2	chr7	146740999	+
5CDS-intron	ENST00000251527	ENST00000538075	ESYT2	chr7	158540885	-	CNTNAP2	chr7	146740999	+
In-frame	ENST00000251527	ENST00000361727	ESYT2	chr7	158540885	-	CNTNAP2	chr7	146740999	+
intron-3CDS	ENST00000435514	ENST00000361727	ESYT2	chr7	158540885	-	CNTNAP2	chr7	146740999	+
intron-3CDS	ENST00000497111	ENST00000361727	ESYT2	chr7	158540885	-	CNTNAP2	chr7	146740999	+
intron-intron	ENST00000435514	ENST00000463592	ESYT2	chr7	158540885	-	CNTNAP2	chr7	146740999	+
intron-intron	ENST00000435514	ENST00000538075	ESYT2	chr7	158540885	-	CNTNAP2	chr7	146740999	+
intron-intron	ENST00000497111	ENST00000463592	ESYT2	chr7	158540885	-	CNTNAP2	chr7	146740999	+
intron-intron	ENST00000497111	ENST00000538075	ESYT2	chr7	158540885	-	CNTNAP2	chr7	146740999	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000251527

ESYT2

chr7

158540885

ENST00000361727

CNTNAP2

chr7

146740999

10767

1791

5384

1772

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000251527	ENST00000361727	ESYT2	chr7	158540885	-	CNTNAP2	chr7	146740999	+	0.000230822	0.99976915

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Fusion Genomic Features for ESYT2-CNTNAP2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
ESYT2	chr7	158540884	-	CNTNAP2	chr7	146740998	+	2.30E-07	0.99999976
ESYT2	chr7	158540884	-	CNTNAP2	chr7	146740998	+	2.30E-07	0.99999976

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ESYT2-CNTNAP2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:158540885/chr7:146740999)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ESYT2 A0FGR8	CNTNAP2 Q9UHC6
FUNCTION: Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport. Plays a role in FGF signaling via its role in the rapid internalization of FGFR1 that has been activated by FGF1 binding; this occurs most likely via the AP-2 complex. Promotes the localization of SACM1L at endoplasmic reticulum-plasma membrane contact sites (EPCS) (PubMed:27044890). {ECO:0000269\|PubMed:17360437, ECO:0000269\|PubMed:20833364, ECO:0000269\|PubMed:23791178, ECO:0000269\|PubMed:24847877, ECO:0000269\|PubMed:27044890}.	FUNCTION: Required for gap junction formation (Probable). Required, with CNTNAP1, for radial and longitudinal organization of myelinated axons. Plays a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Demarcates the juxtaparanodal region of the axo-glial junction. {ECO:0000250\|UniProtKB:Q9CPW0, ECO:0000305\|PubMed:33238150}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ESYT2

chr7:158540885

chr7:146740999

ENST00000251527

191_370

575

894.0

Domain

SMP-LTD

Hgene

ESYT2

chr7:158540885

chr7:146740999

ENST00000251527

369_489

575

894.0

Domain

C2 1

Hgene

ESYT2

chr7:158540885

chr7:146740999

ENST00000251527

125_127

575

894.0

Topological domain

Lumenal

Hgene

ESYT2

chr7:158540885

chr7:146740999

ENST00000251527

1_103

575

894.0

Topological domain

Cytoplasmic

Hgene

ESYT2

chr7:158540885

chr7:146740999

ENST00000251527

104_124

575

894.0

Transmembrane

Helical

Hgene

ESYT2

chr7:158540885

chr7:146740999

ENST00000251527

128_148

575

894.0

Transmembrane

Helical

Tgene

CNTNAP2

chr7:158540885

chr7:146740999

ENST00000361727

1055_1214

134

1332.0

Domain

Laminin G-like 4

Tgene

CNTNAP2

chr7:158540885

chr7:146740999

ENST00000361727

216_368

134

1332.0

Domain

Laminin G-like 1

Tgene

CNTNAP2

chr7:158540885

chr7:146740999

ENST00000361727

401_552

134

1332.0

Domain

Laminin G-like 2

Tgene

CNTNAP2

chr7:158540885

chr7:146740999

ENST00000361727

554_591

134

1332.0

Domain

EGF-like 1

Tgene

CNTNAP2

chr7:158540885

chr7:146740999

ENST00000361727

592_798

134

1332.0

Domain

Fibrinogen C-terminal

Tgene

CNTNAP2

chr7:158540885

chr7:146740999

ENST00000361727

799_963

134

1332.0

Domain

Laminin G-like 3

Tgene

CNTNAP2

chr7:158540885

chr7:146740999

ENST00000361727

963_1002

134

1332.0

Domain

EGF-like 2

Tgene

CNTNAP2

chr7:158540885

chr7:146740999

ENST00000361727

1284_1331

134

1332.0

Topological domain

Cytoplasmic

Tgene

CNTNAP2

chr7:158540885

chr7:146740999

ENST00000361727

1263_1283

134

1332.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ESYT2

chr7:158540885

chr7:146740999

ENST00000251527

736_739

575

894.0

Compositional bias

Note=Poly-Ser

Hgene

ESYT2

chr7:158540885

chr7:146740999

ENST00000251527

514_639

575

894.0

Domain

C2 2

Hgene

ESYT2

chr7:158540885

chr7:146740999

ENST00000251527

786_908

575

894.0

Domain

C2 3

Hgene

ESYT2

chr7:158540885

chr7:146740999

ENST00000251527

149_921

575

894.0

Topological domain

Cytoplasmic

Tgene

CNTNAP2

chr7:158540885

chr7:146740999

ENST00000361727

28_1262

134

1332.0

Topological domain

Extracellular

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Fusion Gene Sequence for ESYT2-CNTNAP2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>27600_27600_1_ESYT2-CNTNAP2_ESYT2_chr7_158540885_ENST00000251527_CNTNAP2_chr7_146740999_ENST00000361727_length(transcript)=10767nt_BP=1791nt
AGTATCCACCCCGCCCGCTCCCGGTGACGTGCCAGCCCCAGGCCCACGCCGCTCCCGCCCCGCGTGATGACGCCACCGTCCCGGGCGGAG
GCGGGCGTGCGGCGGAGCCGCGTCCCCTCAGAGGGGCGCTGGCGCGGGGCTGAGCCGCCCGGGATCAGCGCGAGCACCCAGCCCGCCTCG
GCCGGGAGGGCAGCGCGGCACTGCGGGGCGATGAGCGGCGCCCGGGGCGAGGGCCCGGAGGCGGGCGCCGGCGGGGCTGGGGGCCGCGCG
GCGCCTGAGAACCCCGGGGGCGTGCTGAGCGTGGAGCTGCCCGGGCTGCTGGCGCAGCTGGCGCGGAGCTTCGCGCTGCTGCTGCCCGTG
TACGCGCTGGGCTACCTGGGGCTCAGCTTCAGCTGGGTTCTCCTCGCGCTCGCGCTGCTCGCCTGGTGTCGCCGCAGCCGCGGCCTCAAG
GCCCTGCGCCTGTGCCGCGCGCTGGCGCTGCTGGAAGACGAGGAGCGCGTCGTGCGCCTGGGGGTGCGCGCCTGCGACCTGCCCGCCTGG
GTTCATTTTCCAGACACTGAAAGAGCAGAATGGCTAAATAAGACTGTAAAACACATGTGGCCTTTCATTTGCCAATTTATAGAGAAGTTG
TTTCGAGAAACTATAGAACCAGCCGTGCGGGGAGCAAACACCCACCTTAGCACCTTTAGTTTCACGAAGGTCGACGTGGGCCAGCAGCCC
CTCAGGATCAATGGTGTTAAGGTATACACTGAAAATGTAGACAAAAGGCAAATTATTTTGGACCTTCAGATTAGTTTTGTAGGAAATTGT
GAGATTGATTTGGAGATCAAACGATATTTTTGTAGAGCTGGTGTGAAAAGTATCCAGATTCATGGTACCATGCGGGTGATCCTGGAACCG
TTGATTGGAGATATGCCCTTAGTTGGAGCTTTGTCTATCTTCTTCCTTAGGAAACCACTTTTAGAAATTAACTGGACAGGACTGACGAAT
CTTCTGGATGTCCCTGGATTGAATGGTTTATCAGATACTATCATTTTGGATATAATATCAAACTATCTGGTGCTTCCCAATCGAATCACC
GTTCCACTTGTCAGTGAAGTTCAAATAGCTCAGTTGCGGTTTCCTGTACCAAAGGGTGTTCTAAGGATACATTTTATTGAAGCTCAGGAT
CTTCAGGGGAAAGACACTTACCTTAAGGGACTTGTCAAGGGAAAGTCAGACCCCTATGGAATCATTAGAGTTGGCAACCAAATCTTCCAA
AGCAGAGTCATCAAGGAGAACCTCAGTCCAAAGTGGAATGAAGTCTATGAGGCTTTAGTGTATGAACATCCTGGACAAGAATTAGAGATT
GAGCTCTTTGATGAAGACCCAGACAAGGATGACTTTTTAGGAAGTCTTATGATTGACCTCATTGAAGTTGAAAAGGAGCGCCTTTTAGAT
GAATGGTTCACTCTGGACGAGGTTCCCAAGGGGAAGCTACACTTGAGACTGGAGTGGCTCACGTTAATGCCAAATGCGTCAAACCTCGAC
AAGGTGCTAACAGACATCAAAGCTGACAAAGACCAAGCCAACGATGGTCTTTCCTCTGCATTGCTGATCTTGTACTTGGATTCAGCAAGG
AACCTTCCGTCAGGGAAGAAAATAAGCAGCAACCCAAATCCTGTTGTCCAGATGTCAGTTGGGCACAAGGCCCAGGAGAGCAAGATTCGA
TACAAAACCAATGAACCTGTGTGGGAGGAAAACTTCACTTTCTTCATTCACAATCCCAAGCGCCAGGACCTTGAAGTTGAGGCATTTCCC
GGAAACATTAACTCTGACGGTGTGGTCCGGCACGAATTACAGCATCCGATTATTGCCCGCTATGTGCGCATAGTGCCTCTGGATTGGAAT
GGAGAAGGTCGCATTGGACTCAGAATTGAAGTTTATGGCTGTTCTTACTGGGCTGATGTTATCAACTTTGATGGCCATGTTGTATTACCA
TATAGATTCAGAAACAAGAAGATGAAAACACTGAAAGATGTCATTGCCTTGAACTTTAAGACGTCTGAAAGTGAAGGAGTAATCCTGCAC
GGAGAAGGACAGCAAGGAGATTACATTACCTTGGAACTGAAAAAAGCCAAGCTGGTCCTCAGTTTAAACTTAGGAAGCAACCAGCTTGGC
CCCATATATGGCCACACATCAGTGATGACAGGAAGTTTGCTGGATGACCACCACTGGCACTCTGTGGTCATTGAGCGCCAGGGGCGGAGC
ATTAACCTCACTCTGGACAGGAGCATGCAGCACTTCCGTACCAATGGAGAGTTTGACTACCTGGACTTGGACTATGAGATAACCTTTGGA
GGCATCCCTTTCTCTGGCAAGCCCAGCTCCAGCAGTAGAAAGAATTTCAAAGGCTGCATGGAAAGCATCAACTACAATGGCGTCAACATT
ACTGATCTTGCCAGAAGGAAGAAATTAGAGCCCTCAAATGTGGGAAATTTGAGCTTTTCTTGTGTGGAACCCTATACGGTGCCTGTCTTT
TTCAACGCTACAAGTTACCTGGAGGTGCCCGGACGGCTTAACCAGGACCTGTTCTCAGTCAGTTTCCAGTTTAGGACATGGAACCCCAAT
GGTCTCCTGGTCTTCAGTCACTTTGCGGATAATTTGGGCAATGTGGAGATTGACCTCACTGAAAGCAAAGTGGGTGTTCACATCAACATC
ACACAGACCAAGATGAGCCAAATCGATATTTCCTCAGGTTCTGGGTTGAATGATGGACAGTGGCACGAGGTTCGCTTCCTAGCCAAGGAA
AATTTTGCTATTCTCACCATCGATGGAGATGAAGCATCAGCAGTTCGAACTAATAGTCCCCTTCAAGTTAAAACTGGCGAGAAGTACTTT
TTTGGAGGTTTTCTGAACCAGATGAATAACTCAAGTCACTCTGTCCTTCAGCCTTCATTCCAAGGATGCATGCAGCTCATTCAAGTGGAC
GATCAACTTGTAAATTTATACGAAGTGGCACAAAGGAAGCCGGGAAGTTTCGCGAATGTCAGCATTGACATGTGTGCGATCATAGACAGA
TGTGTGCCCAATCACTGTGAGCATGGTGGAAAGTGCTCGCAAACATGGGACAGCTTCAAATGCACTTGTGATGAGACAGGATACAGTGGG
GCCACCTGCCACAACTCTATCTACGAGCCTTCCTGTGAAGCCTACAAACACCTAGGACAGACATCAAATTATTACTGGATAGATCCTGAT
GGCAGCGGACCTCTGGGGCCTCTGAAAGTTTACTGCAACATGACAGAGGACAAAGTGTGGACCATAGTGTCTCATGACTTGCAGATGCAG
ACGCCTGTGGTCGGCTACAACCCAGAAAAATACTCAGTGACACAGCTCGTTTACAGCGCCTCCATGGACCAGATAAGTGCCATCACTGAC
AGTGCCGAGTACTGCGAGCAGTATGTCTCCTATTTCTGCAAGATGTCAAGATTGTTGAACACCCCAGATGGAAGCCCTTACACTTGGTGG
GTTGGCAAAGCCAACGAGAAGCACTACTACTGGGGAGGCTCTGGGCCTGGAATCCAGAAATGTGCCTGCGGCATCGAACGCAACTGCACA
GATCCCAAGTACTACTGTAACTGCGACGCGGACTACAAGCAATGGAGGAAGGATGCTGGTTTCTTATCATACAAAGATCACCTGCCAGTG
AGCCAAGTGGTGGTTGGAGATACTGACCGTCAAGGCTCAGAAGCCAAATTGAGCGTAGGTCCTCTGCGCTGCCAAGGAGACAGGAATTAT
TGGAATGCCGCCTCTTTCCCAAACCCATCCTCCTACCTGCACTTCTCTACTTTCCAAGGGGAAACTAGCGCTGACATTTCTTTCTACTTC
AAAACATTAACCCCCTGGGGAGTGTTTCTTGAAAATATGGGAAAGGAAGATTTCATCAAGCTGGAGCTGAAGTCTGCCACAGAAGTGTCC
TTTTCATTTGATGTGGGAAATGGGCCAGTAGAGATTGTAGTGAGGTCACCAACCCCTCTCAACGATGACCAGTGGCACCGGGTCACTGCA
GAGAGGAATGTCAAGCAGGCCAGCCTACAGGTGGACCGGCTACCGCAGCAGATCCGCAAGGCCCCAACAGAAGGCCACACCCGCCTGGAG
CTCTACAGCCAGTTATTTGTGGGTGGTGCTGGGGGCCAGCAGGGCTTCCTGGGCTGCATCCGCTCCTTGAGGATGAATGGGGTGACACTT
GACCTGGAGGAAAGAGCAAAGGTCACATCTGGGTTCATATCCGGATGCTCGGGCCATTGCACCAGCTATGGAACAAACTGTGAAAATGGA
GGCAAATGCCTAGAGAGATACCACGGTTACTCCTGCGATTGCTCTAATACTGCATATGATGGAACATTTTGCAACAAAGATGTTGGTGCA
TTTTTTGAAGAAGGGATGTGGCTACGATATAACTTTCAGGCACCAGCAACAAATGCCAGAGACTCCAGCAGCAGAGTAGACAACGCTCCC
GACCAGCAGAACTCCCACCCGGACCTGGCACAGGAGGAGATCCGCTTCAGCTTCAGCACCACCAAGGCGCCCTGCATTCTCCTCTACATC
AGCTCCTTCACCACAGACTTCTTGGCAGTCCTCGTCAAACCCACTGGAAGCTTACAGATTCGATACAACCTGGGTGGCACCCGAGAGCCA
TACAATATTGACGTAGACCACAGGAACATGGCCAATGGACAGCCCCACAGTGTCAACATCACCCGCCACGAGAAGACCATCTTTCTCAAG
CTCGATCATTATCCTTCTGTGAGTTACCATCTGCCAAGTTCATCCGACACCCTCTTCAATTCTCCCAAGTCGCTCTTTCTGGGAAAAGTT
ATAGAAACAGGGAAAATTGACCAAGAGATTCACAAATACAACACCCCAGGATTCACTGGTTGCCTCTCCAGAGTCCAGTTCAACCAGATC
GCCCCTCTCAAGGCCGCCTTGAGGCAGACAAACGCCTCGGCTCACGTCCACATCCAGGGCGAGCTGGTGGAGTCCAACTGCGGGGCCTCG
CCGCTGACCCTCTCCCCCATGTCGTCCGCCACCGACCCCTGGCACCTGGATCACCTGGATTCAGCCAGTGCGGATTTTCCATATAATCCA
GGACAAGGCCAAGCTATAAGAAATGGAGTCAACAGAAACTCGGCTATCATTGGAGGCGTCATTGCTGTGGTGATTTTCACCATCCTGTGC
ACCCTGGTCTTCCTGATCCGGTACATGTTCCGCCACAAGGGCACCTACCATACCAACGAAGCAAAGGGGGCGGAGTCGGCAGAGAGCGCG
GACGCCGCCATCATGAACAACGACCCCAACTTCACAGAGACCATTGATGAAAGCAAAAAGGAATGGCTCATTTGAGGGGTGGCTACTTGG
CTATGGGATAGGGAGGAGGGAATTACTAGGGAGGAGAGAAAGGGACAAAAGCACCCTGCTTCATACTCTTGAGCACATCCTTAAAATATC
AGCACAAGTTGGGGGAGGCAGGCAATGGAATATAATGGAATATTCTTGAGACTGATCACAAAAAAAAAAACCTTTTTAATATTTCTTTAT
AGCTGAGTTTTCCCTTCTGTATCAAAACAAAATAATACAAAAAATGCTTTTAGAGTTTAAGCAATGGTTGAAATTTGTAGGTACTATCTG
TCTTATTTTGTGTGTGTTTAGAGGTGTTCTAAAGACCCGTGGTAACAGGGCAAGTTTTCTACGTTTTTAAGAGCCCTTAGAACGTGGGTA
TTTTTTTTCTTGAGAAAAGCTAATGCACCTACAGATGGCCCCCAACATTCTCTTCCTTTTGCTTCTAGTCAACCTTAATGGGCTGTTACA
GAAACTAGTTCGTGTTTATATACTATTTCCTTTGATGTCCTATAAGTCGGAAAAGAAAGGGGCAAAGAGAACCTATTATTTGCCAGTTTT
TAAGCAGAGCTCAATCTATGCCAGCTCTCTGGCATCTGGGGTTCCTGACTGATACCAGCAGTTGAAGGAAGAGAGTGCATGGCACCTGGT
GTGTAACGACACAATCAGCACAACTGGAGAGAGGCATTAAAGAACCAGGGAAGGTAGTTTGATTTTTCATTGAATTCTACAAGCTAATAT
TGTTCCACGTATGTAGTCTTAGACCAATAGCTGTAACTATCAGCTGCAATACCATGGTGACCAGCTGTTACAAAAGATTTTTTCCTGTTT
TATCTGAAACATACTGGATTTATATATGTATAAGCGCCTCAATGGGGAATTAGAGCCAGATGTTATGATTTGTTTGCTCTTTTTCTTTTA
TAGTTTAGTTATAGCAAAAATATGGATAATTTCTAGTGAATGCATAAATTAGGTTGCGTTTCTTATTTTGCTTTAAATCTCTGGTAGTTT
TTCCACCCCTGTGACACAATCCTAATAGACAGTGTCCTGTAAATGGACACAACACAATAAAGTCAAGTTATTATTGCTGTTACTCTGGAT
GATATGGAAAACACTGCCATATTTTAAATCAACTACTCCACGTGTTTTTCCATCCAATCACACTGCTGTGATTCAGGGATCTTTCTTCTA
AGACGGACACATTTGAACCTCAGGTTCATCACAAACCTGGTACCTGTTGCTTCCCAGAGGATGGAGAAGTGTAGTTAATCACACCTCTTA
GTTTAATCTGAAATCTTGACCCAGTTATTTAACAAATAAATACCTCATTGATTATATTTAAAAGTAATACACTTCCTGTAAACAAATGGG
GACAATGCATCCAAAAAATCTTTTTAAACAGATTACACAAAAATTATTTCCAGAAAGGCTACCATTTATCATCATTATATTTCAAGCCTC
TTATACTTAATAAGCACTTTCTAAAAAGTCTTGAGATCCCACCATTCTGAGGAATTCAATATGATCACTTTTTCCTTCTTTGCCTGGGAG
AGGTTAAGAGGAGGTTTCGAAGGTATAGATGCTATTGTTCTGATGGCCCGGCTGAATAAAATGGAAATTCTAGTTTGTTAGAATTATGCA
TTCTTTTTCAAGATTCTCAGTGTGCCTAACTTATTGGAGCACATCAGTTTCTTGGGTAATGGAAAACATTACCTAGAGTTGCCAGTGGCA
CATTACACCAGTACAGAGCACATTCCAAAGGAGACATTGGACCAGTTAATTCCCATACAAGTCAAGGTAACAGAACAAAAGGGAATCCTG
ATGCCCTTTTACCATTGCTGGTTGAGCTCAGGCACTGTCATGGACACCCTTAATTTTAAAAGGTTTTAATCATTCTTCTATAAAATACAT
TTAAAATGGAAAAATACTTAATATCACTAAATATCAGAACAATGTAACATTTACAAATGACATATTGAAAGCAAAGGCTGTTTTATTTAG
CCAAGATGATTACCATTAGGAGTTACTTTATGTATTGTTGAAAGCAAATTTTAAACATGATGTTTTAGAAGTGTTTCTGATTTTTAAACC
TGGTTTACAGGTATTACTTCTGCACTTACCAAATAATGCCAGATGGAAATTTATTATTTCTTGCAATTCCCATGATAGCTCTGTTCTTTA
TGCATTGTCTCAACACTTTCCCTTTTTTCCCAAAATGAGTAGAGAATTAAAGCCACCCAAAACAGCTTCTGCTACTAAAATGTTCTCATC
CTTTCTCCTCCCTCTCCTTTTCCTGCCACAAAAGGTGAAAAATGAGATCCAATCCTCTCACCAAAATTTCAAACCTAGGACACTGGAATG
ACTGCAGGGATCAGTGGTTCTCCCATATCACCATCAATTAAGACATATAGGACACTGTCTTCCTTCAAGAGGGTTACAATGTGGCCATCA
GACAGGAAACCAAACGGTGGATAAAGTATTAAGTAACTAAGTGCCAAATAAATGCTGGAAATCTTGACCTCTCCTTGGGATTATGGGTGT
AACAAAAATCCCTACATCTGTTTATGAAGGCCATATTCAGTACATTTTAAATGGTAAATAATCTGTTTATGTGAAGAAAAAGAATTAAGT
CTTTCTTCCAACTCTCTCCTTGGATAGCCTAGCACAGTGCAGCCTCCATAACCATGACATTCCCGCCCAAGCTCTCAGTGCCTAATCCTG
CTTTGTCATTCACATCTCACAAAATCTTGACATCTTACATTCCAATACATTATCAAGCAAGCACAAGTATGCTGGTAGTAGCCTCTTTAA
ATAATATGTATAGACAACAACAACGACAAAAAATAGACTGTTTTAAAGTTTCAGGGAAAGTTGGTGGCTGATTTAAAGTTGTGCAGGAAA
CATCTTCTGTGTATGAAGCAAATGTCGATGTTTTGAAAAAAGCTAGGAGATGACTTTGAATGAATGCAAGGTTAGTGAGATCCTAAGCTC
TCAAAATAGCATATTCCCTAGAGCTCAAGAAAGCTGGTCCAGGAGGTTGAAAAAGCTATTTTGTTGTTAAATTATTTTCTGGCCCTTCTT
AATATTTAAAAATGTATTTCCCCTTGTGGCTTTCAACCACCTGCTCAAAAAAAGAGACTTGTTACATGAAAGTTTTCATTAAAGAGCTGA
AAACAAGAATTTAGAGAGCCATTCCTAGAAAATGTCCTACTGCCCTGCATTTGACAAACAAGCATCCTTTACTAACAAGAGCAGGAATTC
AGAGGCACAAGAAAAAGCATTGGCATGAGCCAAAGAGTCTGTCTTAATGTTACTTTTGAAAATCTGCTGAGCGGCCACCATATGCAGGCT
GAGAGCTGGGCACAGGCGAAGCCATTGGAAGCACTTCAGGAACAAGCACACAGCTGTGGGACTTGAACATGCAAGTGTTCAGGTTGTGTC
AAGAAGCTTTTCTTTCCTTCTATGATGGAATCTGTTCTTTTCTATCCTACTTTTTTCTCTCTTCCTCTCCTCACCACATTATACCCTGCT
CTTACGCAGTAAACGTTTTAATGGCCCGTTTATGTCTCATGCCTCCAAACAACACTGAATTTGAAACCCCCCATTTTTTCTTTTCACCAC
CCTGTTGAGCAATTTTCCCAAAAAAAGGGCAGCAATTATTAAATTGAATTCAAGTAAGCCAGCCAAAGATAGGTCCTAAATTGCTAGTCC
CAGTAGAACCACCTGATCCTAAACCAGTGCGAAACAAACAGTAACAATGTCCCCAGCTGACTTCAGCTAAGAACCAATGGCTCCTACCCC
CGCCCCGCTTTTTTTTGTTGTTTTTTGTTTTGTTTTGAGACGGAGTCTTGCTCTGTCCCCCAGGCTGGAGTGCACTGGCGCAATCTCGGG
CTCACTGCAACCTCCTCCTCCTCCCACATTGAGGCGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGCACCCGCCATCACA
CCCAGCTAATTTTTTTTTTTTTTTGTATTATTAGTAGAAGCCAGGTTTCACCATGTTGGCCAGGGTGGTCTCGAACTCCTGACCTCAAGT
GATCCGTCCACCTCGGCCTTGCAAATTGCTGGGATTACAGGTGTGAGCCACCGTGCCGAGCCAGCCCCATTTTTTAAATGATGTTTTGGT
TAAGAGTGGACCATGAGAATTAGCTGACAGCATCCCCTTTCTCTCTCCCTGCCTTGGTGGGACCCTCCCTGTGTGACCTTGGTCAAGTCC
TCGAACTTTTGTCCCGTATTTAAGATGGAGCTGTTTTACCTACTTCATAAGACAGTTGCGAGGTGCCATTGATTCTTGACTGCAAAATAC
CTTGAAACCCTTATATAAAGACTGAAGTCAACGGAGCCTAGTGAAAGACTTACTTTGTGGCTTGTGGTTGAAAGTCACATCAAAAGACAA
ATGTGGCCACGTTCAGGAATTGGAGACTTACTGGCATGGCTCTACAGCTGCTCAGTTATTAATCATGCAGACTAACCTGTCAACACTGGG
AGATGCAACATAGCAAAAGGACAGAGAAATTAGAATTTTTTGTGCAGAAAGCCCTAAATTCCCACCTGAATGTAACTTACAGCTCCCTTA
CCTACTCTCACACATGCCCTCAAACATGCTAGATTGGCTTATACATAGGCCAACACAAAATACAAACGTGACGTGTTCATGTAGCCTAGT
GGCTATATGCCTATTCTCCATGTACCCTGCATGGTAGTGCTGCAAACTTTAAAGTACATTTCTTTCACAGCAGTATTTTTTTTCATAAGT
GGCATATAAATGTCATTCAATGAAATGGGGAAATCACGTTGAGAAGTTGGTCTGTCATCTCCCATTGAGCAAAGACTGGCAGGAGATAAT
AAAAATAAATATGGGCACACATGTATTAATATACAGCACGCATTTACAAGTTTATTTTCCAGATAAAATTGTGCTATAAGAACAGCTCTA
CCAAGACAGTCTGCACCATTTCCAAGTCTCAGTTAATTTACAGCAACTGCTGCTTTCGGAGATGGCTGTGAAAATATGGAAGTTCCTCTC
AAGTAGGCCAAGAAACAGTTCTAGATTTTACTAAGTTTTATTTTGTCAGGTTTTTTAAATTTTTTCAGTGAGCGTGGTGACTGCAGAGGT
TAGTGCTGTGAAAAGCTGGGCTAAATATTCTTTCTGTAAAGTCAAACAGGATTCCATCCCCTGTGAAATAACACAAAATTTCACTCTCTA
AAAGCAACAGCATGTAAACTAGAATGAAAGAAGGAAATTATGTACGTATGCCTAATATTCTTTGTGAATGTCTTTCATTTAACTAAAATT

>27600_27600_1_ESYT2-CNTNAP2_ESYT2_chr7_158540885_ENST00000251527_CNTNAP2_chr7_146740999_ENST00000361727_length(amino acids)=1772AA_BP=575
MTPPSRAEAGVRRSRVPSEGRWRGAEPPGISASTQPASAGRAARHCGAMSGARGEGPEAGAGGAGGRAAPENPGGVLSVELPGLLAQLAR
SFALLLPVYALGYLGLSFSWVLLALALLAWCRRSRGLKALRLCRALALLEDEERVVRLGVRACDLPAWVHFPDTERAEWLNKTVKHMWPF
ICQFIEKLFRETIEPAVRGANTHLSTFSFTKVDVGQQPLRINGVKVYTENVDKRQIILDLQISFVGNCEIDLEIKRYFCRAGVKSIQIHG
TMRVILEPLIGDMPLVGALSIFFLRKPLLEINWTGLTNLLDVPGLNGLSDTIILDIISNYLVLPNRITVPLVSEVQIAQLRFPVPKGVLR
IHFIEAQDLQGKDTYLKGLVKGKSDPYGIIRVGNQIFQSRVIKENLSPKWNEVYEALVYEHPGQELEIELFDEDPDKDDFLGSLMIDLIE
VEKERLLDEWFTLDEVPKGKLHLRLEWLTLMPNASNLDKVLTDIKADKDQANDGLSSALLILYLDSARNLPSGKKISSNPNPVVQMSVGH
KAQESKIRYKTNEPVWEENFTFFIHNPKRQDLEVEAFPGNINSDGVVRHELQHPIIARYVRIVPLDWNGEGRIGLRIEVYGCSYWADVIN
FDGHVVLPYRFRNKKMKTLKDVIALNFKTSESEGVILHGEGQQGDYITLELKKAKLVLSLNLGSNQLGPIYGHTSVMTGSLLDDHHWHSV
VIERQGRSINLTLDRSMQHFRTNGEFDYLDLDYEITFGGIPFSGKPSSSSRKNFKGCMESINYNGVNITDLARRKKLEPSNVGNLSFSCV
EPYTVPVFFNATSYLEVPGRLNQDLFSVSFQFRTWNPNGLLVFSHFADNLGNVEIDLTESKVGVHINITQTKMSQIDISSGSGLNDGQWH
EVRFLAKENFAILTIDGDEASAVRTNSPLQVKTGEKYFFGGFLNQMNNSSHSVLQPSFQGCMQLIQVDDQLVNLYEVAQRKPGSFANVSI
DMCAIIDRCVPNHCEHGGKCSQTWDSFKCTCDETGYSGATCHNSIYEPSCEAYKHLGQTSNYYWIDPDGSGPLGPLKVYCNMTEDKVWTI
VSHDLQMQTPVVGYNPEKYSVTQLVYSASMDQISAITDSAEYCEQYVSYFCKMSRLLNTPDGSPYTWWVGKANEKHYYWGGSGPGIQKCA
CGIERNCTDPKYYCNCDADYKQWRKDAGFLSYKDHLPVSQVVVGDTDRQGSEAKLSVGPLRCQGDRNYWNAASFPNPSSYLHFSTFQGET
SADISFYFKTLTPWGVFLENMGKEDFIKLELKSATEVSFSFDVGNGPVEIVVRSPTPLNDDQWHRVTAERNVKQASLQVDRLPQQIRKAP
TEGHTRLELYSQLFVGGAGGQQGFLGCIRSLRMNGVTLDLEERAKVTSGFISGCSGHCTSYGTNCENGGKCLERYHGYSCDCSNTAYDGT
FCNKDVGAFFEEGMWLRYNFQAPATNARDSSSRVDNAPDQQNSHPDLAQEEIRFSFSTTKAPCILLYISSFTTDFLAVLVKPTGSLQIRY
NLGGTREPYNIDVDHRNMANGQPHSVNITRHEKTIFLKLDHYPSVSYHLPSSSDTLFNSPKSLFLGKVIETGKIDQEIHKYNTPGFTGCL
SRVQFNQIAPLKAALRQTNASAHVHIQGELVESNCGASPLTLSPMSSATDPWHLDHLDSASADFPYNPGQGQAIRNGVNRNSAIIGGVIA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ESYT2-CNTNAP2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for ESYT2-CNTNAP2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for ESYT2-CNTNAP2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source