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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ESYT2-CPED1 (FusionGDB2 ID:27601)

Fusion Gene Summary for ESYT2-CPED1

check button Fusion gene summary
Fusion gene informationFusion gene name: ESYT2-CPED1
Fusion gene ID: 27601
HgeneTgene
Gene symbol

ESYT2

CPED1

Gene ID

57488

79974

Gene nameextended synaptotagmin 2cadherin like and PC-esterase domain containing 1
SynonymsCHR2SYT|E-Syt2|FAM62BC7orf58
Cytomap

7q36.3

7q31.31

Type of geneprotein-codingprotein-coding
Descriptionextended synaptotagmin-2chr2 synaptotagminextended synaptotagmin like protein 2extended synaptotagmin protein 2family with sequence similarity 62 (C2 domain containing), member Bcadherin-like and PC-esterase domain-containing protein 1
Modification date2020031320200313
UniProtAcc

A0FGR8

A4D0V7

Ensembl transtripts involved in fusion geneENST00000251527, ENST00000435514, 
ENST00000497111, 		ENST00000423795, 
ENST00000340646, ENST00000495036, 
ENST00000310396, ENST00000450913, 
Fusion gene scores* DoF score13 X 11 X 10=14309 X 8 X 5=360
# samples 169
** MAII scorelog2(16/1430*10)=-3.15987133677839
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/360*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ESYT2 [Title/Abstract] AND CPED1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointESYT2(158552177)-CPED1(120704292), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ESYT2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CPED1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AQ-A04L-01BESYT2chr7

158552177

-CPED1chr7

120704292

+


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Fusion Gene ORF analysis for ESYT2-CPED1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000251527ENST00000423795ESYT2chr7

158552177

-CPED1chr7

120704292

+
5CDS-intronENST00000251527ENST00000340646ESYT2chr7

158552177

-CPED1chr7

120704292

+
5CDS-intronENST00000251527ENST00000495036ESYT2chr7

158552177

-CPED1chr7

120704292

+
In-frameENST00000251527ENST00000310396ESYT2chr7

158552177

-CPED1chr7

120704292

+
In-frameENST00000251527ENST00000450913ESYT2chr7

158552177

-CPED1chr7

120704292

+
intron-3CDSENST00000435514ENST00000310396ESYT2chr7

158552177

-CPED1chr7

120704292

+
intron-3CDSENST00000435514ENST00000450913ESYT2chr7

158552177

-CPED1chr7

120704292

+
intron-3CDSENST00000497111ENST00000310396ESYT2chr7

158552177

-CPED1chr7

120704292

+
intron-3CDSENST00000497111ENST00000450913ESYT2chr7

158552177

-CPED1chr7

120704292

+
intron-5UTRENST00000435514ENST00000423795ESYT2chr7

158552177

-CPED1chr7

120704292

+
intron-5UTRENST00000497111ENST00000423795ESYT2chr7

158552177

-CPED1chr7

120704292

+
intron-intronENST00000435514ENST00000340646ESYT2chr7

158552177

-CPED1chr7

120704292

+
intron-intronENST00000435514ENST00000495036ESYT2chr7

158552177

-CPED1chr7

120704292

+
intron-intronENST00000497111ENST00000340646ESYT2chr7

158552177

-CPED1chr7

120704292

+
intron-intronENST00000497111ENST00000495036ESYT2chr7

158552177

-CPED1chr7

120704292

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000251527ESYT2chr7158552177-ENST00000310396CPED1chr7120704292+596216296641691367
ENST00000251527ESYT2chr7158552177-ENST00000450913CPED1chr7120704292+356716296634401124

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000251527ENST00000310396ESYT2chr7158552177-CPED1chr7120704292+9.45E-050.99990547
ENST00000251527ENST00000450913ESYT2chr7158552177-CPED1chr7120704292+0.0002522720.9997477

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Fusion Genomic Features for ESYT2-CPED1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ESYT2chr7158552176-CPED1chr7120704291+0.00103050.99896955
ESYT2chr7158552176-CPED1chr7120704291+0.00103050.99896955

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ESYT2-CPED1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:158552177/chr7:120704292)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ESYT2

A0FGR8

CPED1

A4D0V7

FUNCTION: Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport. Plays a role in FGF signaling via its role in the rapid internalization of FGFR1 that has been activated by FGF1 binding; this occurs most likely via the AP-2 complex. Promotes the localization of SACM1L at endoplasmic reticulum-plasma membrane contact sites (EPCS) (PubMed:27044890). {ECO:0000269|PubMed:17360437, ECO:0000269|PubMed:20833364, ECO:0000269|PubMed:23791178, ECO:0000269|PubMed:24847877, ECO:0000269|PubMed:27044890}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneESYT2chr7:158552177chr7:120704292ENST00000251527-1322191_370521894.0DomainSMP-LTD
HgeneESYT2chr7:158552177chr7:120704292ENST00000251527-1322369_489521894.0DomainC2 1
HgeneESYT2chr7:158552177chr7:120704292ENST00000251527-1322125_127521894.0Topological domainLumenal
HgeneESYT2chr7:158552177chr7:120704292ENST00000251527-13221_103521894.0Topological domainCytoplasmic
HgeneESYT2chr7:158552177chr7:120704292ENST00000251527-1322104_124521894.0TransmembraneHelical
HgeneESYT2chr7:158552177chr7:120704292ENST00000251527-1322128_148521894.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneESYT2chr7:158552177chr7:120704292ENST00000251527-1322736_739521894.0Compositional biasNote=Poly-Ser
HgeneESYT2chr7:158552177chr7:120704292ENST00000251527-1322514_639521894.0DomainC2 2
HgeneESYT2chr7:158552177chr7:120704292ENST00000251527-1322786_908521894.0DomainC2 3
HgeneESYT2chr7:158552177chr7:120704292ENST00000251527-1322149_921521894.0Topological domainCytoplasmic


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Fusion Gene Sequence for ESYT2-CPED1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>27601_27601_1_ESYT2-CPED1_ESYT2_chr7_158552177_ENST00000251527_CPED1_chr7_120704292_ENST00000310396_length(transcript)=5962nt_BP=1629nt
AGTATCCACCCCGCCCGCTCCCGGTGACGTGCCAGCCCCAGGCCCACGCCGCTCCCGCCCCGCGTGATGACGCCACCGTCCCGGGCGGAG
GCGGGCGTGCGGCGGAGCCGCGTCCCCTCAGAGGGGCGCTGGCGCGGGGCTGAGCCGCCCGGGATCAGCGCGAGCACCCAGCCCGCCTCG
GCCGGGAGGGCAGCGCGGCACTGCGGGGCGATGAGCGGCGCCCGGGGCGAGGGCCCGGAGGCGGGCGCCGGCGGGGCTGGGGGCCGCGCG
GCGCCTGAGAACCCCGGGGGCGTGCTGAGCGTGGAGCTGCCCGGGCTGCTGGCGCAGCTGGCGCGGAGCTTCGCGCTGCTGCTGCCCGTG
TACGCGCTGGGCTACCTGGGGCTCAGCTTCAGCTGGGTTCTCCTCGCGCTCGCGCTGCTCGCCTGGTGTCGCCGCAGCCGCGGCCTCAAG
GCCCTGCGCCTGTGCCGCGCGCTGGCGCTGCTGGAAGACGAGGAGCGCGTCGTGCGCCTGGGGGTGCGCGCCTGCGACCTGCCCGCCTGG
GTTCATTTTCCAGACACTGAAAGAGCAGAATGGCTAAATAAGACTGTAAAACACATGTGGCCTTTCATTTGCCAATTTATAGAGAAGTTG
TTTCGAGAAACTATAGAACCAGCCGTGCGGGGAGCAAACACCCACCTTAGCACCTTTAGTTTCACGAAGGTCGACGTGGGCCAGCAGCCC
CTCAGGATCAATGGTGTTAAGGTATACACTGAAAATGTAGACAAAAGGCAAATTATTTTGGACCTTCAGATTAGTTTTGTAGGAAATTGT
GAGATTGATTTGGAGATCAAACGATATTTTTGTAGAGCTGGTGTGAAAAGTATCCAGATTCATGGTACCATGCGGGTGATCCTGGAACCG
TTGATTGGAGATATGCCCTTAGTTGGAGCTTTGTCTATCTTCTTCCTTAGGAAACCACTTTTAGAAATTAACTGGACAGGACTGACGAAT
CTTCTGGATGTCCCTGGATTGAATGGTTTATCAGATACTATCATTTTGGATATAATATCAAACTATCTGGTGCTTCCCAATCGAATCACC
GTTCCACTTGTCAGTGAAGTTCAAATAGCTCAGTTGCGGTTTCCTGTACCAAAGGGTGTTCTAAGGATACATTTTATTGAAGCTCAGGAT
CTTCAGGGGAAAGACACTTACCTTAAGGGACTTGTCAAGGGAAAGTCAGACCCCTATGGAATCATTAGAGTTGGCAACCAAATCTTCCAA
AGCAGAGTCATCAAGGAGAACCTCAGTCCAAAGTGGAATGAAGTCTATGAGGCTTTAGTGTATGAACATCCTGGACAAGAATTAGAGATT
GAGCTCTTTGATGAAGACCCAGACAAGGATGACTTTTTAGGAAGTCTTATGATTGACCTCATTGAAGTTGAAAAGGAGCGCCTTTTAGAT
GAATGGTTCACTCTGGACGAGGTTCCCAAGGGGAAGCTACACTTGAGACTGGAGTGGCTCACGTTAATGCCAAATGCGTCAAACCTCGAC
AAGGTGCTAACAGACATCAAAGCTGACAAAGACCAAGCCAACGATGGTCTTTCCTCTGCATTGCTGATCTTGTACTTGGATTCAGCAAGG
AACCTTCCGGCAAACAGATTACCAGAAATACAGCAGCCACTTTGCAGAAAGGAAGGATTATGTCAAATAGTTAGAAGATTCCCAGAACTG
CAACTTCCAGTGAGTCCCTCTGTGTGTCTGGATCAGGGAATGCAATTAAAGCCGAGTACTTCGAGTCACCTTTTAAAAACAGTGAAGCCA
CGTGTGTGGAAACCAGGGGACTGGAGTCGTGAACAGCTGAATGAAACGACAGTCCTTGCTCCACATGAAACAATCTTTCGAGCCGAAGAT
CTATCTGTGATTCTTAAAGCGTATGTGTTGGTGACGTCCTTAACCCCTTTGCGTGCATTCATTCATTCGACGGGCACAGTTTGGAATCCA
CCAAAGAAAAAACGCTTCACTGTCAAGCTGCAAACATTTTTTGAGACATTCCTGAGAGCCAGTTCACCTCAACAGGCTTTTGACATTATG
AAGGAAGCAATTGGCAAACTACTGCTAGCGGCTGAAGTATTCAGTGAAACATCTACTCTGGGACCAAAGACCTTCCATAGATGCAGATTC
TGCTTTCAACTTCTAACTTTTGATATTGGTTATGGCAGTTTCATGTACCCTGTAGTGCTCCAGGTACACGAGCATTTAAATTTTCAAGAT
TATGATAATATGGATTTTGAGGACCAAAATACAGAAGAATTCCTTTTAAATGACACTTTCAATTTTCTCTTCCCTAATGAATCATCACTT
TCCATATTTTCTGAGATATTTCAGAGACTTTATAGATCAGATGTTTTCAAGGGTGAAAACTATCAAAAGGAACTAAATCAGTGTCTGTCC
TTAGAAGAAATTAACTCAATTATGACTTTCATAAAGGAACTTGGAAGTCTGGGACAATTCCAACTGCTCTTCCCATCTACTACTCCTGGG
ATTCAGTCACTGATGCATGAATTTTATGATGTGGCAAATCCTGTGGGAAATCCTGGCTCAGTCCTGACCCAATACTGGTCTCTTTTAAAT
GTATTTGAACAATTTCAGTTCATGAATAAAAAGACACAGCCACATCCACTGGAATGGAATTCTTTCACAGAAGATAAGAACATTGAAAAA
CCACAAGTGCCATTTGATGCAATAGAAAATAAAAAAGCTGCAGTTCCACAAATTAAAAATGAAAATAAAGAAATACATTGCAGTGATGAT
GAAAACACACCATGTCATATCAAGCAGATCTTCACACATCCACATTTGGAACTAAATCCTGACTTTCATCCAAAGATCAAAGATTATTAC
TGTGAAGTCCCATTTGATGTGGTAACAGTGACAATTGGAGTGGAAACTCCTAAGTGTCTGTGCAAGGTGCACCTGTACGAGCAGGCAGGG
CCAAGCTTTGCCAGCTACCCTCTGGGCTTAGGAATGAACAAAATCTCAATATTTGTTGTGGATGAATCTCCAGCACACGGTGAGACTCTG
ATCACGTACAAACTCACCATCTATAGAGAAGACCGCCCAAGTCTGCCCTTGTTTGAGGCCTTCACAGCATGTGGTTTTGTGCAGGATTGT
GGTTTGCTGATTCATCCAGAGGAAACCTGTGGGTTACAGCCTATTTCTTCTGACTACATTGAAGCCATTTTACAGTCTGAACTAAAAAGA
TGTCCATCTGGGGACATGAAAGGCCAGTGGATTGTGCCTTGCCTTAGTTGTTCGGACAACAGGACGTGTGACTGGAGAGAAATAACCTGG
CAGCCCCACAACTGCCAATATGGTGTCCTAACTAAGCCTCAACTCCAGCAGTGCCTGGGAGGAAGGAAGATTCTGTTCATTGGAGATTCA
ACCAACAGAGGGATCATGTACTATCTTATTGAAAGGCTGAATGAAACGTTGCAGGAATGGCAGAAAGTACATGGCACTAAATTCTATCAC
AACGTCAATGGTGGGAAGACTTTGATCAGTTATTCCTACTATCCCCAGTTCTGGATAAGCCCTTCATTGAGACCAACATTTGAAAATGCA
CTTGAACACCTCTTGCAAAGATCACGTCCCCTAGAGAATACTGGCCAGACTGTATTGGTTGTTGGTGGTGTTCAGTGGCTTAATTCCAAT
CACCTGCAAATTATTCACAAAGTTTTGAAGAGGGAAAATTTACTCAATATCCTAGTGATCATCAAAACTTTGGGAATTGGATTTCATCTG
CCAGTGGATGGAGTACATTTCTTAACACAGAGTGAAGTACAGAACTTATGGAAAGAAAATTTGATTATTCTGGATACTGCAAAAAAACAT
GGCTATGAAGTAGTTGACACATTCACTATAACAATGGGGCGTTACAAAGAGTTTCTACAGGGGAAGTGTGGATGTCATTTCCATGAGGTA
GTGAAATCAAAGTTATCCAAAGAATATAACTTTATTAAAATGAAAAGATCAAGAAATCATATCATGGGAAGATATTTCAGCAATCAAAGC
AAACTACAACAAGGCACTGTAACAAATTTTCGATCGCCATATCATGTCAGAGGTCCAATAAATCAGGTTTGTTCTGAAATCCTTCTCAGC
AGGATGTGTGCAAATAAAAGGACTATGTAGGCTCCCTGCAGGAGAGCTGAATCTGGAGCTGGAGACGAGCTAGTCACCCGGACAATGGTC
TAGGAGCCAAGCGCTGCACATCGCACACATTTGGGATCGACCACACACACTTGTGCACACCAGCACATGCATGCACACCAGTACACACAC
AGTTAAATAATGATAACACTTCTTACAGCTTTATGAATTCAAGATGTGACCTTGAACACCAGTCCATTTCACAGTGAAAGATATACCTAG
AGAAACGTTACTTGAAGCATAATTATTAACCAGAACCACTGTGGGCCAGGTATGGCATTGTGATAATAAAGAGAAATATAGACACTTAAA
ATTATGTGAAAAAAAGGATAATGCTCTTTCATGTTGTCTTACCATATCTATAGGTACATCAATATTGAAAAGGAGAAAAACCAATGACAT
TCCACTGGCAAGTAGAAGTTGTCCTTTCATTCTTTACCAGGAGAAAATGTGATGTTTATGATGGCTTAGGCTTTGTGAATCTAATGCTTA
TGAAAAACATTTCTTCCTATACTTTTTAAATTTTATTACTGAAAGGAAAAGAACAGGAATGTTCCACAAGGGAATTTGAAGAGATTCTGT
GAGAGAGATATGAAATATTTTATAGTTAAAACACCAATATATTCAACTTTACACTTCTTGTGTTTTTCATAAACATTCCCTCTTGTCTTA
TCTGTGTACTTCGATGGGTAACTGCAGTCTGAATTAATGAAATATGTAATTTTAAAGTAAGTAACAAAATGTAGTTCCTCATGTATTACT
GTACTATGTTTCATTGATGATATTACTTAAATCTTGTGTTTGCCATTACAGCCCTATGTAACTTAAAATTACAATTATATTTTATGTAAA
TATTTTGCAAAGGACTATGCATTCTGAAATGCATAGGTGCTTTTTCCCACCAAGCATTTGCATATGTCCACAAATAGTATTATGTTACTA
GTATCTATATTTTGATTTTCCTGAGCAACTGTATCAAATCCAAATTTAGATTAGACAAAAAATTATTATTTTAATTAAACTGTGGCATAC
ATATAATACATACCTAATTATAGTAGTGAGAACTATTTCTTTTATCTCTTTAGGTTCAAAATGGTGAATTTCTTTATTATATGAATGCTT
TGTTGTGAGATAACATCACACTGTTACAATGGATTTTAGAGGTTTGTCTTTTTTGGGTGGGGTGGGAAGCTGAGAGGGTTAATTCAATAC
ATGGCTGAAATTACCAAATGTATAAATACCTCATTTTCACTACCATACAAGAAAAAAACACCTATTTTGATTGATCAGTTCTTTTGTATG
AATATCCACCTCCTTTAAATACTCTATTTTTATATATATTTTTATATGAAGATAAACATGAATTTATATTTAACTGTCTTAAATTATATT
TACATAAATGCAAATATCACTTGATATAAACAATACAAATCTGCATCTTACAGATGATAATTTTTTTAGAAGAATGATACAGAATTAACT
TTAAAAATAAAACTTTTCTAATATACACTTAAATGCAAACATCATTTTTAAATTTTCAGTGATTTTTTTAATGACATAAAACGTTACCAA
TGTGTGCAGCCTCTCCATCATGTTTTAACATACTGTATACTCTATAGCAGTATTACAGTCAGTATTTCATATAATTTTCTTTAGACCTAA
CTGTTACCATCTGACTGAGGTTACTCTGGTATTTATCTCTTCGCTGCTGAAATAATAATGGATTTTAGAAACAATTGTAATAATATCATT

>27601_27601_1_ESYT2-CPED1_ESYT2_chr7_158552177_ENST00000251527_CPED1_chr7_120704292_ENST00000310396_length(amino acids)=1367AA_BP=521
MTPPSRAEAGVRRSRVPSEGRWRGAEPPGISASTQPASAGRAARHCGAMSGARGEGPEAGAGGAGGRAAPENPGGVLSVELPGLLAQLAR
SFALLLPVYALGYLGLSFSWVLLALALLAWCRRSRGLKALRLCRALALLEDEERVVRLGVRACDLPAWVHFPDTERAEWLNKTVKHMWPF
ICQFIEKLFRETIEPAVRGANTHLSTFSFTKVDVGQQPLRINGVKVYTENVDKRQIILDLQISFVGNCEIDLEIKRYFCRAGVKSIQIHG
TMRVILEPLIGDMPLVGALSIFFLRKPLLEINWTGLTNLLDVPGLNGLSDTIILDIISNYLVLPNRITVPLVSEVQIAQLRFPVPKGVLR
IHFIEAQDLQGKDTYLKGLVKGKSDPYGIIRVGNQIFQSRVIKENLSPKWNEVYEALVYEHPGQELEIELFDEDPDKDDFLGSLMIDLIE
VEKERLLDEWFTLDEVPKGKLHLRLEWLTLMPNASNLDKVLTDIKADKDQANDGLSSALLILYLDSARNLPANRLPEIQQPLCRKEGLCQ
IVRRFPELQLPVSPSVCLDQGMQLKPSTSSHLLKTVKPRVWKPGDWSREQLNETTVLAPHETIFRAEDLSVILKAYVLVTSLTPLRAFIH
STGTVWNPPKKKRFTVKLQTFFETFLRASSPQQAFDIMKEAIGKLLLAAEVFSETSTLGPKTFHRCRFCFQLLTFDIGYGSFMYPVVLQV
HEHLNFQDYDNMDFEDQNTEEFLLNDTFNFLFPNESSLSIFSEIFQRLYRSDVFKGENYQKELNQCLSLEEINSIMTFIKELGSLGQFQL
LFPSTTPGIQSLMHEFYDVANPVGNPGSVLTQYWSLLNVFEQFQFMNKKTQPHPLEWNSFTEDKNIEKPQVPFDAIENKKAAVPQIKNEN
KEIHCSDDENTPCHIKQIFTHPHLELNPDFHPKIKDYYCEVPFDVVTVTIGVETPKCLCKVHLYEQAGPSFASYPLGLGMNKISIFVVDE
SPAHGETLITYKLTIYREDRPSLPLFEAFTACGFVQDCGLLIHPEETCGLQPISSDYIEAILQSELKRCPSGDMKGQWIVPCLSCSDNRT
CDWREITWQPHNCQYGVLTKPQLQQCLGGRKILFIGDSTNRGIMYYLIERLNETLQEWQKVHGTKFYHNVNGGKTLISYSYYPQFWISPS
LRPTFENALEHLLQRSRPLENTGQTVLVVGGVQWLNSNHLQIIHKVLKRENLLNILVIIKTLGIGFHLPVDGVHFLTQSEVQNLWKENLI
ILDTAKKHGYEVVDTFTITMGRYKEFLQGKCGCHFHEVVKSKLSKEYNFIKMKRSRNHIMGRYFSNQSKLQQGTVTNFRSPYHVRGPINQ

--------------------------------------------------------------
>27601_27601_2_ESYT2-CPED1_ESYT2_chr7_158552177_ENST00000251527_CPED1_chr7_120704292_ENST00000450913_length(transcript)=3567nt_BP=1629nt
AGTATCCACCCCGCCCGCTCCCGGTGACGTGCCAGCCCCAGGCCCACGCCGCTCCCGCCCCGCGTGATGACGCCACCGTCCCGGGCGGAG
GCGGGCGTGCGGCGGAGCCGCGTCCCCTCAGAGGGGCGCTGGCGCGGGGCTGAGCCGCCCGGGATCAGCGCGAGCACCCAGCCCGCCTCG
GCCGGGAGGGCAGCGCGGCACTGCGGGGCGATGAGCGGCGCCCGGGGCGAGGGCCCGGAGGCGGGCGCCGGCGGGGCTGGGGGCCGCGCG
GCGCCTGAGAACCCCGGGGGCGTGCTGAGCGTGGAGCTGCCCGGGCTGCTGGCGCAGCTGGCGCGGAGCTTCGCGCTGCTGCTGCCCGTG
TACGCGCTGGGCTACCTGGGGCTCAGCTTCAGCTGGGTTCTCCTCGCGCTCGCGCTGCTCGCCTGGTGTCGCCGCAGCCGCGGCCTCAAG
GCCCTGCGCCTGTGCCGCGCGCTGGCGCTGCTGGAAGACGAGGAGCGCGTCGTGCGCCTGGGGGTGCGCGCCTGCGACCTGCCCGCCTGG
GTTCATTTTCCAGACACTGAAAGAGCAGAATGGCTAAATAAGACTGTAAAACACATGTGGCCTTTCATTTGCCAATTTATAGAGAAGTTG
TTTCGAGAAACTATAGAACCAGCCGTGCGGGGAGCAAACACCCACCTTAGCACCTTTAGTTTCACGAAGGTCGACGTGGGCCAGCAGCCC
CTCAGGATCAATGGTGTTAAGGTATACACTGAAAATGTAGACAAAAGGCAAATTATTTTGGACCTTCAGATTAGTTTTGTAGGAAATTGT
GAGATTGATTTGGAGATCAAACGATATTTTTGTAGAGCTGGTGTGAAAAGTATCCAGATTCATGGTACCATGCGGGTGATCCTGGAACCG
TTGATTGGAGATATGCCCTTAGTTGGAGCTTTGTCTATCTTCTTCCTTAGGAAACCACTTTTAGAAATTAACTGGACAGGACTGACGAAT
CTTCTGGATGTCCCTGGATTGAATGGTTTATCAGATACTATCATTTTGGATATAATATCAAACTATCTGGTGCTTCCCAATCGAATCACC
GTTCCACTTGTCAGTGAAGTTCAAATAGCTCAGTTGCGGTTTCCTGTACCAAAGGGTGTTCTAAGGATACATTTTATTGAAGCTCAGGAT
CTTCAGGGGAAAGACACTTACCTTAAGGGACTTGTCAAGGGAAAGTCAGACCCCTATGGAATCATTAGAGTTGGCAACCAAATCTTCCAA
AGCAGAGTCATCAAGGAGAACCTCAGTCCAAAGTGGAATGAAGTCTATGAGGCTTTAGTGTATGAACATCCTGGACAAGAATTAGAGATT
GAGCTCTTTGATGAAGACCCAGACAAGGATGACTTTTTAGGAAGTCTTATGATTGACCTCATTGAAGTTGAAAAGGAGCGCCTTTTAGAT
GAATGGTTCACTCTGGACGAGGTTCCCAAGGGGAAGCTACACTTGAGACTGGAGTGGCTCACGTTAATGCCAAATGCGTCAAACCTCGAC
AAGGTGCTAACAGACATCAAAGCTGACAAAGACCAAGCCAACGATGGTCTTTCCTCTGCATTGCTGATCTTGTACTTGGATTCAGCAAGG
AACCTTCCGGCAAACAGATTACCAGAAATACAGCAGCCACTTTGCAGAAAGGAAGGATTATGTCAAATAGTTAGAAGATTCCCAGAACTG
CAACTTCCAGTGAGTCCCTCTGTGTGTCTGGATCAGGGAATGCAATTAAAGCCGAGTACTTCGAGTCACCTTTTAAAAACAGTGAAGCCA
CGTGTGTGGAAACCAGGGGACTGGAGTCGTGAACAGCTGAATGAAACGACAGTCCTTGCTCCACATGAAACAATCTTTCGAGCCGAAGAT
CTATCTGTGATTCTTAAAGCGTATGTGTTGGTGACGTCCTTAACCCCTTTGCGTGCATTCATTCATTCGACGGGCACAGTTTGGAATCCA
CCAAAGAAAAAACGCTTCACTGTCAAGCTGCAAACATTTTTTGAGACATTCCTGAGAGCCAGTTCACCTCAACAGGCTTTTGACATTATG
AAGGAAGCAATTGGCAAACTACTGCTAGCGGCTGAAGTATTCAGTGAAACATCTACTCTGGGACCAAAGACCTTCCATAGATGCAGATTC
TGCTTTCAACTTCTAACTTTTGATATTGGTTATGGCAGTTTCATGTACCCTGTAGTGCTCCAGGTACACGAGCATTTAAATTTTCAAGAT
TATGATAATATGGATTTTGAGGACCAAAATACAGAAGAATTCCTTTTAAATGACACTTTCAATTTTCTCTTCCCTAATGAATCATCACTT
TCCATATTTTCTGAGATATTTCAGAGACTTTATAGATCAGATGTTTTCAAGGGTGAAAACTATCAAAAGGAACTAAATCAGTGTCTGTCC
TTAGAAGAAATTAACTCAATTATGACTTTCATAAAGGAACTTGGAAGTCTGGGACAATTCCAACTGCTCTTCCCATCTACTACTCCTGGG
ATTCAGTCACTGATGCATGAATTTTATGATGTGGCAAATCCTGTGGGAAATCCTGGCTCAGTCCTGACCCAATACTGGTCTCTTTTAAAT
GTATTTGAACAATTTCAGTTCATGAATAAAAAGACACAGCCACATCCACTGGAATGGAATTCTTTCACAGAAGATAAGAACATTGAAAAA
CCACAAGTGCCATTTGATGCAATAGAAAATAAAAAAGCTGCAGTTCCACAAATTAAAAATGAAAATAAAGAAATACATTGCAGTGATGAT
GAAAACACACCATGTCATATCAAGCAGATCTTCACACATCCACATTTGGAACTAAATCCTGACTTTCATCCAAAGATCAAAGATTATTAC
TGTGAAGTCCCATTTGATGTGGTAACAGTGACAATTGGAGTGGAAACTCCTAAGTGTCTGTGCAAGGTGCACCTGTACGAGCAGGCAGGG
CCAAGCTTTGCCAGCTACCCTCTGGGCTTAGGAATGAACAAAATCTCAATATTTGTTGTGGATGAATCTCCAGCACACGGTGAGACTCTG
ATCACGTACAAACTCACCATCTATAGAGAAGACCGCCCAAGTCTGCCCTTGTTTGAGGCCTTCACAGCATGTGGTTTTGTGCAGGATTGT
GGTTTGCTGATTCATCCAGAGGAAACCTGTGGGTTACAGCCTATTTCTTCTGACTACATTGAAGCCATTTTACAGTCTGAACTAAAAAGA
TGTCCATCTGGGGACATGAAAGGCCAGTGGATTGTGCCTTGCCTTAGTTGTTCGGACAACAGGACGTGTGACTGGAGAGAAATAACCTGG
CAGCCCCACAACTGCCAATATGGTGTCCTAACTAAGCCTCAACTCCAGCAGTGCCTGGGAGGAAGGAAGTTGGGTGTCGATGTCCAGAGA
GTTCCTAGAAGCCGTAATTGAAGACACAATCCAGTCATCCTGGGACCCTAAATGACCTCCCTGCCCCACCCCTGCACATAAACCTGACTT

>27601_27601_2_ESYT2-CPED1_ESYT2_chr7_158552177_ENST00000251527_CPED1_chr7_120704292_ENST00000450913_length(amino acids)=1124AA_BP=521
MTPPSRAEAGVRRSRVPSEGRWRGAEPPGISASTQPASAGRAARHCGAMSGARGEGPEAGAGGAGGRAAPENPGGVLSVELPGLLAQLAR
SFALLLPVYALGYLGLSFSWVLLALALLAWCRRSRGLKALRLCRALALLEDEERVVRLGVRACDLPAWVHFPDTERAEWLNKTVKHMWPF
ICQFIEKLFRETIEPAVRGANTHLSTFSFTKVDVGQQPLRINGVKVYTENVDKRQIILDLQISFVGNCEIDLEIKRYFCRAGVKSIQIHG
TMRVILEPLIGDMPLVGALSIFFLRKPLLEINWTGLTNLLDVPGLNGLSDTIILDIISNYLVLPNRITVPLVSEVQIAQLRFPVPKGVLR
IHFIEAQDLQGKDTYLKGLVKGKSDPYGIIRVGNQIFQSRVIKENLSPKWNEVYEALVYEHPGQELEIELFDEDPDKDDFLGSLMIDLIE
VEKERLLDEWFTLDEVPKGKLHLRLEWLTLMPNASNLDKVLTDIKADKDQANDGLSSALLILYLDSARNLPANRLPEIQQPLCRKEGLCQ
IVRRFPELQLPVSPSVCLDQGMQLKPSTSSHLLKTVKPRVWKPGDWSREQLNETTVLAPHETIFRAEDLSVILKAYVLVTSLTPLRAFIH
STGTVWNPPKKKRFTVKLQTFFETFLRASSPQQAFDIMKEAIGKLLLAAEVFSETSTLGPKTFHRCRFCFQLLTFDIGYGSFMYPVVLQV
HEHLNFQDYDNMDFEDQNTEEFLLNDTFNFLFPNESSLSIFSEIFQRLYRSDVFKGENYQKELNQCLSLEEINSIMTFIKELGSLGQFQL
LFPSTTPGIQSLMHEFYDVANPVGNPGSVLTQYWSLLNVFEQFQFMNKKTQPHPLEWNSFTEDKNIEKPQVPFDAIENKKAAVPQIKNEN
KEIHCSDDENTPCHIKQIFTHPHLELNPDFHPKIKDYYCEVPFDVVTVTIGVETPKCLCKVHLYEQAGPSFASYPLGLGMNKISIFVVDE
SPAHGETLITYKLTIYREDRPSLPLFEAFTACGFVQDCGLLIHPEETCGLQPISSDYIEAILQSELKRCPSGDMKGQWIVPCLSCSDNRT

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Fusion Gene PPI Analysis for ESYT2-CPED1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ESYT2-CPED1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ESYT2-CPED1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource