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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ETFA-METTL9 (FusionGDB2 ID:27628)

Fusion Gene Summary for ETFA-METTL9

check button Fusion gene summary
Fusion gene informationFusion gene name: ETFA-METTL9
Fusion gene ID: 27628
HgeneTgene
Gene symbol

ETFA

METTL9

Gene ID

2108

51108

Gene nameelectron transfer flavoprotein subunit alphamethyltransferase like 9
SynonymsEMA|GA2|MADDCGI-81|DREV|DREV1|PAP1
Cytomap

15q24.2-q24.3

16p12.2

Type of geneprotein-codingprotein-coding
Descriptionelectron transfer flavoprotein subunit alpha, mitochondrialalpha-ETFelectron transfer flavoprotein alpha subunitelectron transfer flavoprotein, alpha polypeptideepididymis secretory sperm binding proteinglutaric aciduria IImethyltransferase-like protein 9CTB-31N19.3DORA reverse strand protein 1p53 activated protein 1
Modification date2020031320200313
UniProtAcc.

Q9H1A3

Ensembl transtripts involved in fusion geneENST00000433983, ENST00000557943, 
ENST00000559602, ENST00000560726, 
ENST00000560816, 		ENST00000563026, 
ENST00000358154, ENST00000396014, 
Fusion gene scores* DoF score12 X 8 X 5=4806 X 5 X 6=180
# samples 126
** MAII scorelog2(12/480*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/180*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ETFA [Title/Abstract] AND METTL9 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointETFA(76603691)-METTL9(21623966), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneETFA

GO:0033539

fatty acid beta-oxidation using acyl-CoA dehydrogenase

25416781


check buttonFusion gene breakpoints across ETFA (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across METTL9 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4KIRPTCGA-MH-A55Z-01AETFAchr15

76603691

-METTL9chr16

21623966

+


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Fusion Gene ORF analysis for ETFA-METTL9

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000433983ENST00000563026ETFAchr15

76603691

-METTL9chr16

21623966

+
5CDS-intronENST00000557943ENST00000563026ETFAchr15

76603691

-METTL9chr16

21623966

+
5CDS-intronENST00000559602ENST00000563026ETFAchr15

76603691

-METTL9chr16

21623966

+
5UTR-3CDSENST00000560726ENST00000358154ETFAchr15

76603691

-METTL9chr16

21623966

+
5UTR-3CDSENST00000560726ENST00000396014ETFAchr15

76603691

-METTL9chr16

21623966

+
5UTR-intronENST00000560726ENST00000563026ETFAchr15

76603691

-METTL9chr16

21623966

+
In-frameENST00000433983ENST00000358154ETFAchr15

76603691

-METTL9chr16

21623966

+
In-frameENST00000433983ENST00000396014ETFAchr15

76603691

-METTL9chr16

21623966

+
In-frameENST00000557943ENST00000358154ETFAchr15

76603691

-METTL9chr16

21623966

+
In-frameENST00000557943ENST00000396014ETFAchr15

76603691

-METTL9chr16

21623966

+
In-frameENST00000559602ENST00000358154ETFAchr15

76603691

-METTL9chr16

21623966

+
In-frameENST00000559602ENST00000396014ETFAchr15

76603691

-METTL9chr16

21623966

+
intron-3CDSENST00000560816ENST00000358154ETFAchr15

76603691

-METTL9chr16

21623966

+
intron-3CDSENST00000560816ENST00000396014ETFAchr15

76603691

-METTL9chr16

21623966

+
intron-intronENST00000560816ENST00000563026ETFAchr15

76603691

-METTL9chr16

21623966

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000557943ETFAchr1576603691-ENST00000358154METTL9chr1621623966+29531209911300
ENST00000557943ETFAchr1576603691-ENST00000396014METTL9chr1621623966+15961209908299
ENST00000433983ETFAchr1576603691-ENST00000358154METTL9chr1621623966+28885516846276
ENST00000433983ETFAchr1576603691-ENST00000396014METTL9chr1621623966+15315516843275
ENST00000559602ETFAchr1576603691-ENST00000358154METTL9chr1621623966+28986526856276
ENST00000559602ETFAchr1576603691-ENST00000396014METTL9chr1621623966+15416526853275

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000557943ENST00000358154ETFAchr1576603691-METTL9chr1621623966+0.0002649990.99973494
ENST00000557943ENST00000396014ETFAchr1576603691-METTL9chr1621623966+0.0003285260.99967146
ENST00000433983ENST00000358154ETFAchr1576603691-METTL9chr1621623966+0.0002653650.9997346
ENST00000433983ENST00000396014ETFAchr1576603691-METTL9chr1621623966+0.0003280420.99967194
ENST00000559602ENST00000358154ETFAchr1576603691-METTL9chr1621623966+0.0002675850.99973243
ENST00000559602ENST00000396014ETFAchr1576603691-METTL9chr1621623966+0.0003142880.99968576

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Fusion Genomic Features for ETFA-METTL9


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ETFAchr1576603690-METTL9chr1621623965+2.41E-050.9999759
ETFAchr1576603690-METTL9chr1621623965+2.41E-050.9999759

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ETFA-METTL9


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:76603691/chr16:21623966)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.METTL9

Q9H1A3

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneETFAchr15:76603691chr16:21623966ENST00000433983-111263_26613285.0Nucleotide bindingFAD
HgeneETFAchr15:76603691chr16:21623966ENST00000433983-111281_28613285.0Nucleotide bindingFAD
HgeneETFAchr15:76603691chr16:21623966ENST00000433983-111318_31913285.0Nucleotide bindingFAD
HgeneETFAchr15:76603691chr16:21623966ENST00000557943-112263_26613334.0Nucleotide bindingFAD
HgeneETFAchr15:76603691chr16:21623966ENST00000557943-112281_28613334.0Nucleotide bindingFAD
HgeneETFAchr15:76603691chr16:21623966ENST00000557943-112318_31913334.0Nucleotide bindingFAD
HgeneETFAchr15:76603691chr16:21623966ENST00000433983-111205_33313285.0RegionDomain II
HgeneETFAchr15:76603691chr16:21623966ENST00000433983-11120_20413285.0RegionDomain I
HgeneETFAchr15:76603691chr16:21623966ENST00000557943-112205_33313334.0RegionDomain II
HgeneETFAchr15:76603691chr16:21623966ENST00000557943-11220_20413334.0RegionDomain I
TgeneMETTL9chr15:76603691chr16:21623966ENST000003581540544_4755319.0Compositional biasNote=Poly-Ala
TgeneMETTL9chr15:76603691chr16:21623966ENST000003960140544_4755318.0Compositional biasNote=Poly-Ala


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Fusion Gene Sequence for ETFA-METTL9


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>27628_27628_1_ETFA-METTL9_ETFA_chr15_76603691_ENST00000433983_METTL9_chr16_21623966_ENST00000358154_length(transcript)=2888nt_BP=55nt
GGCGGAAGCGGAGACCATGTTCCGAGCGGCGGCTCCGGGGCAGCTCCGGCGGGCGTGGTATGTGTGCAACAGAGAGAAATTATGCGAATC
ACTCCAGGCTGTCTTTGTTCAGAGTTACCTTGATCAAGGAACACAGATCTTCTTAAACAACAGCATTGAGAAATCGGGCTGGCTATTTAT
CCAATTATATCATTCTTTTGTGTCATCTGTTTTTAGCCTGTTTATGTCTAGAACATCTATCAATGGGTTGCTAGGAAGAGGCTCAATGTT
TGTGTTTTCACCAGATCAGTTTCAGAGACTGCTTAAAATTAATCCAGACTGGAAAACCCACAGACTTCTTGATTTAGGTGCTGGAGATGG
AGAAGTCACAAAAATCATGAGCCCTCATTTTGAAGAAATCTATGCCACTGAGCTTTCTGAAACTATGATATGGCAGCTTCAGAAAAAGAA
ATACAGAGTCCTTGGTATAAATGAATGGCAGAATACGGGGTTCCAGTATGATGTCATCAGCTGCCTGAACTTGCTGGACCGCTGTGATCA
GCCCCTGACTTTGTTAAAAGATATCAGAAGTGTCTTGGAGCCAACTAGAGGCAGGGTCATCCTTGCCCTTGTCCTCCCCTTTCATCCCTA
TGTGGAAAACGTAGGTGGCAAGTGGGAGAAACCATCAGAAATTTTGGAAATCAAAGGACAGAACTGGGAAGAACAAGTGAATAGTCTGCC
TGAAGTTTTCAGAAAAGCTGGTTTTGTTATCGAAGCTTTCACCAGACTACCATACCTGTGTGAAGGCGACATGTATAATGACTACTACGT
TCTGGATGACGCTGTCTTTGTTCTCAAACCAGTATAAACACGTGGAGGTCGAAGTCTTCAGAGTCCGCACCCTCCGGGATGTGCCCTTGG
AAGAGGGTCTGTGTTCACAATTACGTGAAGGGAGGACCCTTGGGGACCGCCATTCTAAATATCATGTAGGAATTTAAAAAGCCAAAATAC
TAATTATTTCTTTGTAGTGTGTAAAGGAATGTTTTTAAAAGACAAAAACCCAACTCTTTGTGGATTTTTATCAACTCTTTACTCAGAGCC
ACTCTCCAATGCAGGTCACACTCCAATTATGATGGAAGATATTTTTTATACTTAATTGCAGTAGGGACTCATTCCCAGACAAAGCAATAG
TCACGACTTCATGGAACCAATCAATGGATTGTTTTTTGAAGACTGGCAATAAAGCTGTCCATTCAATTCCAAATACTGGTTTTAAGGTAT
AGCCACTGATATTCTTTCATGTTTAGAAATTCTTTCTGTTATTATTCAAGAAAATGTTTTTAATCATGCTAATAAACTTTTTTGGAGATG
ACTTTGGCATCATGTTTGAATTCATATAAAGCTCCCCTAGCATTTTTTATTGGTTTGGCTTCAGGAGTACCCAAATAGTAGCATTATGAG
AATGACGCAGACAATTTGAATAGGGGGGAAGGAAGGCTTCAGACTTGGGGGAAGGGGAGATTATTGCAAATTGCAGTGAACACTGAGTCA
GTAAAAAAAAAAAACAGAAACAAAAACCCAGCCTCATTCAGATACAGAACTTCAGGGACCCCTCCCCCCACCCCCCCAGTTAATGCTGCT
GTGAAAAATGCAAAATAACCTGGTTCTGACTTTGTGATCACTCATGTCCCATACACTGAACTTTGTTTTTTTCTGGACAATCTCAGGTTC
TCAGAATTGAAACATTCAGTTTTGTCTACTGACAAAATGCAACTAAAAATGTTTTAATTCAACTTCTTACTCTACACTTATATACCTCTC
TCCCAGAGCTTGGCTCTTCCCTGAAATCCTTAAAGGAGTTTATTATTTGCCAAGAATATGGTTTGATGAAGACCGTGTCAGACTCATGCA
TTCTGGAATCCGTGAGTGCCTCCAACCATAAACCCAGAAATGCTGCCATAGAGGAACCCATTAGCAAGATCAATAACCATCGTGGATATT
CCAAAGAGCAGAGCATTTAACCCAGAATCTGAAATCTCAGTAATAACAGAAATGTCAATATGAGATTGTGGTTATTAACAATATGTTATC
CTCACTACTTTATTTCTTTTTTCATCCAGGTGTTTCATTAAGTATTCTCATTTATATGCTCATAGAAGTCATCAGATCAACACATTCACT
CCAACACCTGGGTATAAAGGCGAATTAAAACCTGAAGAATTACTTTATTATTCATTAAGAACTGCATTCCCACATCCTCACACCAATATC
TTCCACTGTTACTGTGCAGTCATAATAAGAGTTGGGTTATGTGATTTATGCAAAATTGTTATTGGTGTGTTCTAATGATTTTTTTCCAGG
AATTCAAGTAAGTGAAGTACAAATACTTAGCACCATAGATTGTAAAAATAGAAAGAGGAAATGAGAAAACTTAATGTCGTTCTTGTACAG
TTGAGTTTTGCTTCTTTATAAACTGTCTGTTAAAATCAGGGGTTGCTGTTAGACTGTCAAGCAGAAGTGATGGATGTTCAAGGAGGCAGG
TTGCCCCAAAGTGTTTTCTAACTTTCAAGTAGAGAACTTTATGCTCTAATAAGAAAAATACAACTCATTCTTAACCACCCCCCCAAAACA
GAGAAAACACATACATTTATGCATTTTAAAGATAAAAAGTAGTTTCTCAAAAAAATCTGAAGTTCTCTGAAAACCAGCTTATTAAAAGTG
CTGTTTTGTGGTGAAAATTGAAACCAAATCCACTCACATTTCCTATCGGGTCTTGAAATTCTTGGTGGTGTGTCACCATTCCACTAGATG
GCAGTGTTGCTTACTGAGTGTCAATGGCTTTTTTCCCCGTAAATGGAATCATGTTTTTCTCCCCCAAAGTACAATAAAGCTGCCTTGTCT

>27628_27628_1_ETFA-METTL9_ETFA_chr15_76603691_ENST00000433983_METTL9_chr16_21623966_ENST00000358154_length(amino acids)=276AA_BP=13
MFRAAAPGQLRRAWYVCNREKLCESLQAVFVQSYLDQGTQIFLNNSIEKSGWLFIQLYHSFVSSVFSLFMSRTSINGLLGRGSMFVFSPD
QFQRLLKINPDWKTHRLLDLGAGDGEVTKIMSPHFEEIYATELSETMIWQLQKKKYRVLGINEWQNTGFQYDVISCLNLLDRCDQPLTLL
KDIRSVLEPTRGRVILALVLPFHPYVENVGGKWEKPSEILEIKGQNWEEQVNSLPEVFRKAGFVIEAFTRLPYLCEGDMYNDYYVLDDAV

--------------------------------------------------------------
>27628_27628_2_ETFA-METTL9_ETFA_chr15_76603691_ENST00000433983_METTL9_chr16_21623966_ENST00000396014_length(transcript)=1531nt_BP=55nt
GGCGGAAGCGGAGACCATGTTCCGAGCGGCGGCTCCGGGGCAGCTCCGGCGGGCGTGGTATGTGTGCAACAGAGAGAAATTATGCGAATC
ACTCCAGGCTGTCTTTGTTCAGAGTTACCTTGATCAAGGAACACAGATCTTCTTAAACAACAGCATTGAGAAATCGGGCTGGCTATTTAT
CCAATTATATCATTCTTTTGTGTCATCTGTTTTTAGCCTGTTTATGTCTAGAACATCTATCAATGGGTTGCTAGGAAGAGGCTCAATGTT
TGTGTTTTCACCAGATCAGTTTCAGAGACTGCTTAAAATTAATCCAGACTGGAAAACCCACAGACTTCTTGATTTAGGTGCTGGAGATGG
AGAAGTCACAAAAATCATGAGCCCTCATTTTGAAGAAATCTATGCCACTGAGCTTTCTGAAACTATGATATGGCAGCTTCAGAAAAAGAA
ATACAGAGTCCTTGGTATAAATGAATGGCAGAATACGGGGTTCCAGTATGATGTCATCAGCTGCCTGAACTTGCTGGACCGCTGTGATCA
GCCCCTGACTTTGTTAAAAGATATCAGAAGTGTCTTGGAGCCAACTAGAGGCAGGGTCATCCTTGCCCTTGTCCTCCCCTTTCATCCCTA
TGTGGAAAACGGTGGCAAGTGGGAGAAACCATCAGAAATTTTGGAAATCAAAGGACAGAACTGGGAAGAACAAGTGAATAGTCTGCCTGA
AGTTTTCAGAAAAGCTGGTTTTGTTATCGAAGCTTTCACCAGACTACCATACCTGTGTGAAGGCGACATGTATAATGACTACTACGTTCT
GGATGACGCTGTCTTTGTTCTCAAACCAGTATAAACACGTGGAGGTCGAAGTCTTCAGAGTCCGCACCCTCCGGGATGTGCCCTTGGAAG
AGGGTCTGTGTTCACAATTACGTGAAGGGAGGACCCTTGGGGACCGCCATTCTAAATATCATGTAGGAATTTAAAAAGCCAAAATACTAA
TTATTTCTTTGTAGTGTGTAAAGGAATGTTTTTAAAAGACAAAAACCCAACTCTTTGTGGATTTTTATCAACTCTTTACTCAGAGCCACT
CTCCAATGCAGGTCACACTCCAATTATGATGGAAGATATTTTTTATACTTAATTGCAGTAGGGACTCATTCCCAGACAAAGCAATAGTCA
CGACTTCATGGAACCAATCAATGGATTGTTTTTTGAAGACTGGCAATAAAGCTGTCCATTCAATTCCAAATACTGGTTTTAAGGTATAGC
CACTGATATTCTTTCATGTTTAGAAATTCTTTCTGTTATTATTCAAGAAAATGTTTTTAATCATGCTAATAAACTTTTTTGGAGATGACT
TTGGCATCATGTTTGAATTCATATAAAGCTCCCCTAGCATTTTTTATTGGTTTGGCTTCAGGAGTACCCAAATAGTAGCATTATGAGAAT
GACGCAGACAATTTGAATAGGGGGGAAGGAAGGCTTCAGACTTGGGGGAAGGGGAGATTATTGCAAATTGCAGTGAACACTGAGTCAGTA

>27628_27628_2_ETFA-METTL9_ETFA_chr15_76603691_ENST00000433983_METTL9_chr16_21623966_ENST00000396014_length(amino acids)=275AA_BP=13
MFRAAAPGQLRRAWYVCNREKLCESLQAVFVQSYLDQGTQIFLNNSIEKSGWLFIQLYHSFVSSVFSLFMSRTSINGLLGRGSMFVFSPD
QFQRLLKINPDWKTHRLLDLGAGDGEVTKIMSPHFEEIYATELSETMIWQLQKKKYRVLGINEWQNTGFQYDVISCLNLLDRCDQPLTLL
KDIRSVLEPTRGRVILALVLPFHPYVENGGKWEKPSEILEIKGQNWEEQVNSLPEVFRKAGFVIEAFTRLPYLCEGDMYNDYYVLDDAVF

--------------------------------------------------------------
>27628_27628_3_ETFA-METTL9_ETFA_chr15_76603691_ENST00000557943_METTL9_chr16_21623966_ENST00000358154_length(transcript)=2953nt_BP=120nt
ATTAGGTGACTGGCTGAGGCGGCGCCAGTTGGCCGGGCACGGGGCTGCTGTAAGGCCGAGGTTGCGGCGGAAGCGGAGACCATGTTCCGA
GCGGCGGCTCCGGGGCAGCTCCGGCGGGCGTGGTATGTGTGCAACAGAGAGAAATTATGCGAATCACTCCAGGCTGTCTTTGTTCAGAGT
TACCTTGATCAAGGAACACAGATCTTCTTAAACAACAGCATTGAGAAATCGGGCTGGCTATTTATCCAATTATATCATTCTTTTGTGTCA
TCTGTTTTTAGCCTGTTTATGTCTAGAACATCTATCAATGGGTTGCTAGGAAGAGGCTCAATGTTTGTGTTTTCACCAGATCAGTTTCAG
AGACTGCTTAAAATTAATCCAGACTGGAAAACCCACAGACTTCTTGATTTAGGTGCTGGAGATGGAGAAGTCACAAAAATCATGAGCCCT
CATTTTGAAGAAATCTATGCCACTGAGCTTTCTGAAACTATGATATGGCAGCTTCAGAAAAAGAAATACAGAGTCCTTGGTATAAATGAA
TGGCAGAATACGGGGTTCCAGTATGATGTCATCAGCTGCCTGAACTTGCTGGACCGCTGTGATCAGCCCCTGACTTTGTTAAAAGATATC
AGAAGTGTCTTGGAGCCAACTAGAGGCAGGGTCATCCTTGCCCTTGTCCTCCCCTTTCATCCCTATGTGGAAAACGTAGGTGGCAAGTGG
GAGAAACCATCAGAAATTTTGGAAATCAAAGGACAGAACTGGGAAGAACAAGTGAATAGTCTGCCTGAAGTTTTCAGAAAAGCTGGTTTT
GTTATCGAAGCTTTCACCAGACTACCATACCTGTGTGAAGGCGACATGTATAATGACTACTACGTTCTGGATGACGCTGTCTTTGTTCTC
AAACCAGTATAAACACGTGGAGGTCGAAGTCTTCAGAGTCCGCACCCTCCGGGATGTGCCCTTGGAAGAGGGTCTGTGTTCACAATTACG
TGAAGGGAGGACCCTTGGGGACCGCCATTCTAAATATCATGTAGGAATTTAAAAAGCCAAAATACTAATTATTTCTTTGTAGTGTGTAAA
GGAATGTTTTTAAAAGACAAAAACCCAACTCTTTGTGGATTTTTATCAACTCTTTACTCAGAGCCACTCTCCAATGCAGGTCACACTCCA
ATTATGATGGAAGATATTTTTTATACTTAATTGCAGTAGGGACTCATTCCCAGACAAAGCAATAGTCACGACTTCATGGAACCAATCAAT
GGATTGTTTTTTGAAGACTGGCAATAAAGCTGTCCATTCAATTCCAAATACTGGTTTTAAGGTATAGCCACTGATATTCTTTCATGTTTA
GAAATTCTTTCTGTTATTATTCAAGAAAATGTTTTTAATCATGCTAATAAACTTTTTTGGAGATGACTTTGGCATCATGTTTGAATTCAT
ATAAAGCTCCCCTAGCATTTTTTATTGGTTTGGCTTCAGGAGTACCCAAATAGTAGCATTATGAGAATGACGCAGACAATTTGAATAGGG
GGGAAGGAAGGCTTCAGACTTGGGGGAAGGGGAGATTATTGCAAATTGCAGTGAACACTGAGTCAGTAAAAAAAAAAAACAGAAACAAAA
ACCCAGCCTCATTCAGATACAGAACTTCAGGGACCCCTCCCCCCACCCCCCCAGTTAATGCTGCTGTGAAAAATGCAAAATAACCTGGTT
CTGACTTTGTGATCACTCATGTCCCATACACTGAACTTTGTTTTTTTCTGGACAATCTCAGGTTCTCAGAATTGAAACATTCAGTTTTGT
CTACTGACAAAATGCAACTAAAAATGTTTTAATTCAACTTCTTACTCTACACTTATATACCTCTCTCCCAGAGCTTGGCTCTTCCCTGAA
ATCCTTAAAGGAGTTTATTATTTGCCAAGAATATGGTTTGATGAAGACCGTGTCAGACTCATGCATTCTGGAATCCGTGAGTGCCTCCAA
CCATAAACCCAGAAATGCTGCCATAGAGGAACCCATTAGCAAGATCAATAACCATCGTGGATATTCCAAAGAGCAGAGCATTTAACCCAG
AATCTGAAATCTCAGTAATAACAGAAATGTCAATATGAGATTGTGGTTATTAACAATATGTTATCCTCACTACTTTATTTCTTTTTTCAT
CCAGGTGTTTCATTAAGTATTCTCATTTATATGCTCATAGAAGTCATCAGATCAACACATTCACTCCAACACCTGGGTATAAAGGCGAAT
TAAAACCTGAAGAATTACTTTATTATTCATTAAGAACTGCATTCCCACATCCTCACACCAATATCTTCCACTGTTACTGTGCAGTCATAA
TAAGAGTTGGGTTATGTGATTTATGCAAAATTGTTATTGGTGTGTTCTAATGATTTTTTTCCAGGAATTCAAGTAAGTGAAGTACAAATA
CTTAGCACCATAGATTGTAAAAATAGAAAGAGGAAATGAGAAAACTTAATGTCGTTCTTGTACAGTTGAGTTTTGCTTCTTTATAAACTG
TCTGTTAAAATCAGGGGTTGCTGTTAGACTGTCAAGCAGAAGTGATGGATGTTCAAGGAGGCAGGTTGCCCCAAAGTGTTTTCTAACTTT
CAAGTAGAGAACTTTATGCTCTAATAAGAAAAATACAACTCATTCTTAACCACCCCCCCAAAACAGAGAAAACACATACATTTATGCATT
TTAAAGATAAAAAGTAGTTTCTCAAAAAAATCTGAAGTTCTCTGAAAACCAGCTTATTAAAAGTGCTGTTTTGTGGTGAAAATTGAAACC
AAATCCACTCACATTTCCTATCGGGTCTTGAAATTCTTGGTGGTGTGTCACCATTCCACTAGATGGCAGTGTTGCTTACTGAGTGTCAAT

>27628_27628_3_ETFA-METTL9_ETFA_chr15_76603691_ENST00000557943_METTL9_chr16_21623966_ENST00000358154_length(amino acids)=300AA_BP=37
MAEAAPVGRARGCCKAEVAAEAETMFRAAAPGQLRRAWYVCNREKLCESLQAVFVQSYLDQGTQIFLNNSIEKSGWLFIQLYHSFVSSVF
SLFMSRTSINGLLGRGSMFVFSPDQFQRLLKINPDWKTHRLLDLGAGDGEVTKIMSPHFEEIYATELSETMIWQLQKKKYRVLGINEWQN
TGFQYDVISCLNLLDRCDQPLTLLKDIRSVLEPTRGRVILALVLPFHPYVENVGGKWEKPSEILEIKGQNWEEQVNSLPEVFRKAGFVIE

--------------------------------------------------------------
>27628_27628_4_ETFA-METTL9_ETFA_chr15_76603691_ENST00000557943_METTL9_chr16_21623966_ENST00000396014_length(transcript)=1596nt_BP=120nt
ATTAGGTGACTGGCTGAGGCGGCGCCAGTTGGCCGGGCACGGGGCTGCTGTAAGGCCGAGGTTGCGGCGGAAGCGGAGACCATGTTCCGA
GCGGCGGCTCCGGGGCAGCTCCGGCGGGCGTGGTATGTGTGCAACAGAGAGAAATTATGCGAATCACTCCAGGCTGTCTTTGTTCAGAGT
TACCTTGATCAAGGAACACAGATCTTCTTAAACAACAGCATTGAGAAATCGGGCTGGCTATTTATCCAATTATATCATTCTTTTGTGTCA
TCTGTTTTTAGCCTGTTTATGTCTAGAACATCTATCAATGGGTTGCTAGGAAGAGGCTCAATGTTTGTGTTTTCACCAGATCAGTTTCAG
AGACTGCTTAAAATTAATCCAGACTGGAAAACCCACAGACTTCTTGATTTAGGTGCTGGAGATGGAGAAGTCACAAAAATCATGAGCCCT
CATTTTGAAGAAATCTATGCCACTGAGCTTTCTGAAACTATGATATGGCAGCTTCAGAAAAAGAAATACAGAGTCCTTGGTATAAATGAA
TGGCAGAATACGGGGTTCCAGTATGATGTCATCAGCTGCCTGAACTTGCTGGACCGCTGTGATCAGCCCCTGACTTTGTTAAAAGATATC
AGAAGTGTCTTGGAGCCAACTAGAGGCAGGGTCATCCTTGCCCTTGTCCTCCCCTTTCATCCCTATGTGGAAAACGGTGGCAAGTGGGAG
AAACCATCAGAAATTTTGGAAATCAAAGGACAGAACTGGGAAGAACAAGTGAATAGTCTGCCTGAAGTTTTCAGAAAAGCTGGTTTTGTT
ATCGAAGCTTTCACCAGACTACCATACCTGTGTGAAGGCGACATGTATAATGACTACTACGTTCTGGATGACGCTGTCTTTGTTCTCAAA
CCAGTATAAACACGTGGAGGTCGAAGTCTTCAGAGTCCGCACCCTCCGGGATGTGCCCTTGGAAGAGGGTCTGTGTTCACAATTACGTGA
AGGGAGGACCCTTGGGGACCGCCATTCTAAATATCATGTAGGAATTTAAAAAGCCAAAATACTAATTATTTCTTTGTAGTGTGTAAAGGA
ATGTTTTTAAAAGACAAAAACCCAACTCTTTGTGGATTTTTATCAACTCTTTACTCAGAGCCACTCTCCAATGCAGGTCACACTCCAATT
ATGATGGAAGATATTTTTTATACTTAATTGCAGTAGGGACTCATTCCCAGACAAAGCAATAGTCACGACTTCATGGAACCAATCAATGGA
TTGTTTTTTGAAGACTGGCAATAAAGCTGTCCATTCAATTCCAAATACTGGTTTTAAGGTATAGCCACTGATATTCTTTCATGTTTAGAA
ATTCTTTCTGTTATTATTCAAGAAAATGTTTTTAATCATGCTAATAAACTTTTTTGGAGATGACTTTGGCATCATGTTTGAATTCATATA
AAGCTCCCCTAGCATTTTTTATTGGTTTGGCTTCAGGAGTACCCAAATAGTAGCATTATGAGAATGACGCAGACAATTTGAATAGGGGGG

>27628_27628_4_ETFA-METTL9_ETFA_chr15_76603691_ENST00000557943_METTL9_chr16_21623966_ENST00000396014_length(amino acids)=299AA_BP=37
MAEAAPVGRARGCCKAEVAAEAETMFRAAAPGQLRRAWYVCNREKLCESLQAVFVQSYLDQGTQIFLNNSIEKSGWLFIQLYHSFVSSVF
SLFMSRTSINGLLGRGSMFVFSPDQFQRLLKINPDWKTHRLLDLGAGDGEVTKIMSPHFEEIYATELSETMIWQLQKKKYRVLGINEWQN
TGFQYDVISCLNLLDRCDQPLTLLKDIRSVLEPTRGRVILALVLPFHPYVENGGKWEKPSEILEIKGQNWEEQVNSLPEVFRKAGFVIEA

--------------------------------------------------------------
>27628_27628_5_ETFA-METTL9_ETFA_chr15_76603691_ENST00000559602_METTL9_chr16_21623966_ENST00000358154_length(transcript)=2898nt_BP=65nt
CCGAGGTTGCGGCGGAAGCGGAGACCATGTTCCGAGCGGCGGCTCCGGGGCAGCTCCGGCGGGCGTGGTATGTGTGCAACAGAGAGAAAT
TATGCGAATCACTCCAGGCTGTCTTTGTTCAGAGTTACCTTGATCAAGGAACACAGATCTTCTTAAACAACAGCATTGAGAAATCGGGCT
GGCTATTTATCCAATTATATCATTCTTTTGTGTCATCTGTTTTTAGCCTGTTTATGTCTAGAACATCTATCAATGGGTTGCTAGGAAGAG
GCTCAATGTTTGTGTTTTCACCAGATCAGTTTCAGAGACTGCTTAAAATTAATCCAGACTGGAAAACCCACAGACTTCTTGATTTAGGTG
CTGGAGATGGAGAAGTCACAAAAATCATGAGCCCTCATTTTGAAGAAATCTATGCCACTGAGCTTTCTGAAACTATGATATGGCAGCTTC
AGAAAAAGAAATACAGAGTCCTTGGTATAAATGAATGGCAGAATACGGGGTTCCAGTATGATGTCATCAGCTGCCTGAACTTGCTGGACC
GCTGTGATCAGCCCCTGACTTTGTTAAAAGATATCAGAAGTGTCTTGGAGCCAACTAGAGGCAGGGTCATCCTTGCCCTTGTCCTCCCCT
TTCATCCCTATGTGGAAAACGTAGGTGGCAAGTGGGAGAAACCATCAGAAATTTTGGAAATCAAAGGACAGAACTGGGAAGAACAAGTGA
ATAGTCTGCCTGAAGTTTTCAGAAAAGCTGGTTTTGTTATCGAAGCTTTCACCAGACTACCATACCTGTGTGAAGGCGACATGTATAATG
ACTACTACGTTCTGGATGACGCTGTCTTTGTTCTCAAACCAGTATAAACACGTGGAGGTCGAAGTCTTCAGAGTCCGCACCCTCCGGGAT
GTGCCCTTGGAAGAGGGTCTGTGTTCACAATTACGTGAAGGGAGGACCCTTGGGGACCGCCATTCTAAATATCATGTAGGAATTTAAAAA
GCCAAAATACTAATTATTTCTTTGTAGTGTGTAAAGGAATGTTTTTAAAAGACAAAAACCCAACTCTTTGTGGATTTTTATCAACTCTTT
ACTCAGAGCCACTCTCCAATGCAGGTCACACTCCAATTATGATGGAAGATATTTTTTATACTTAATTGCAGTAGGGACTCATTCCCAGAC
AAAGCAATAGTCACGACTTCATGGAACCAATCAATGGATTGTTTTTTGAAGACTGGCAATAAAGCTGTCCATTCAATTCCAAATACTGGT
TTTAAGGTATAGCCACTGATATTCTTTCATGTTTAGAAATTCTTTCTGTTATTATTCAAGAAAATGTTTTTAATCATGCTAATAAACTTT
TTTGGAGATGACTTTGGCATCATGTTTGAATTCATATAAAGCTCCCCTAGCATTTTTTATTGGTTTGGCTTCAGGAGTACCCAAATAGTA
GCATTATGAGAATGACGCAGACAATTTGAATAGGGGGGAAGGAAGGCTTCAGACTTGGGGGAAGGGGAGATTATTGCAAATTGCAGTGAA
CACTGAGTCAGTAAAAAAAAAAAACAGAAACAAAAACCCAGCCTCATTCAGATACAGAACTTCAGGGACCCCTCCCCCCACCCCCCCAGT
TAATGCTGCTGTGAAAAATGCAAAATAACCTGGTTCTGACTTTGTGATCACTCATGTCCCATACACTGAACTTTGTTTTTTTCTGGACAA
TCTCAGGTTCTCAGAATTGAAACATTCAGTTTTGTCTACTGACAAAATGCAACTAAAAATGTTTTAATTCAACTTCTTACTCTACACTTA
TATACCTCTCTCCCAGAGCTTGGCTCTTCCCTGAAATCCTTAAAGGAGTTTATTATTTGCCAAGAATATGGTTTGATGAAGACCGTGTCA
GACTCATGCATTCTGGAATCCGTGAGTGCCTCCAACCATAAACCCAGAAATGCTGCCATAGAGGAACCCATTAGCAAGATCAATAACCAT
CGTGGATATTCCAAAGAGCAGAGCATTTAACCCAGAATCTGAAATCTCAGTAATAACAGAAATGTCAATATGAGATTGTGGTTATTAACA
ATATGTTATCCTCACTACTTTATTTCTTTTTTCATCCAGGTGTTTCATTAAGTATTCTCATTTATATGCTCATAGAAGTCATCAGATCAA
CACATTCACTCCAACACCTGGGTATAAAGGCGAATTAAAACCTGAAGAATTACTTTATTATTCATTAAGAACTGCATTCCCACATCCTCA
CACCAATATCTTCCACTGTTACTGTGCAGTCATAATAAGAGTTGGGTTATGTGATTTATGCAAAATTGTTATTGGTGTGTTCTAATGATT
TTTTTCCAGGAATTCAAGTAAGTGAAGTACAAATACTTAGCACCATAGATTGTAAAAATAGAAAGAGGAAATGAGAAAACTTAATGTCGT
TCTTGTACAGTTGAGTTTTGCTTCTTTATAAACTGTCTGTTAAAATCAGGGGTTGCTGTTAGACTGTCAAGCAGAAGTGATGGATGTTCA
AGGAGGCAGGTTGCCCCAAAGTGTTTTCTAACTTTCAAGTAGAGAACTTTATGCTCTAATAAGAAAAATACAACTCATTCTTAACCACCC
CCCCAAAACAGAGAAAACACATACATTTATGCATTTTAAAGATAAAAAGTAGTTTCTCAAAAAAATCTGAAGTTCTCTGAAAACCAGCTT
ATTAAAAGTGCTGTTTTGTGGTGAAAATTGAAACCAAATCCACTCACATTTCCTATCGGGTCTTGAAATTCTTGGTGGTGTGTCACCATT
CCACTAGATGGCAGTGTTGCTTACTGAGTGTCAATGGCTTTTTTCCCCGTAAATGGAATCATGTTTTTCTCCCCCAAAGTACAATAAAGC

>27628_27628_5_ETFA-METTL9_ETFA_chr15_76603691_ENST00000559602_METTL9_chr16_21623966_ENST00000358154_length(amino acids)=276AA_BP=13
MFRAAAPGQLRRAWYVCNREKLCESLQAVFVQSYLDQGTQIFLNNSIEKSGWLFIQLYHSFVSSVFSLFMSRTSINGLLGRGSMFVFSPD
QFQRLLKINPDWKTHRLLDLGAGDGEVTKIMSPHFEEIYATELSETMIWQLQKKKYRVLGINEWQNTGFQYDVISCLNLLDRCDQPLTLL
KDIRSVLEPTRGRVILALVLPFHPYVENVGGKWEKPSEILEIKGQNWEEQVNSLPEVFRKAGFVIEAFTRLPYLCEGDMYNDYYVLDDAV

--------------------------------------------------------------
>27628_27628_6_ETFA-METTL9_ETFA_chr15_76603691_ENST00000559602_METTL9_chr16_21623966_ENST00000396014_length(transcript)=1541nt_BP=65nt
CCGAGGTTGCGGCGGAAGCGGAGACCATGTTCCGAGCGGCGGCTCCGGGGCAGCTCCGGCGGGCGTGGTATGTGTGCAACAGAGAGAAAT
TATGCGAATCACTCCAGGCTGTCTTTGTTCAGAGTTACCTTGATCAAGGAACACAGATCTTCTTAAACAACAGCATTGAGAAATCGGGCT
GGCTATTTATCCAATTATATCATTCTTTTGTGTCATCTGTTTTTAGCCTGTTTATGTCTAGAACATCTATCAATGGGTTGCTAGGAAGAG
GCTCAATGTTTGTGTTTTCACCAGATCAGTTTCAGAGACTGCTTAAAATTAATCCAGACTGGAAAACCCACAGACTTCTTGATTTAGGTG
CTGGAGATGGAGAAGTCACAAAAATCATGAGCCCTCATTTTGAAGAAATCTATGCCACTGAGCTTTCTGAAACTATGATATGGCAGCTTC
AGAAAAAGAAATACAGAGTCCTTGGTATAAATGAATGGCAGAATACGGGGTTCCAGTATGATGTCATCAGCTGCCTGAACTTGCTGGACC
GCTGTGATCAGCCCCTGACTTTGTTAAAAGATATCAGAAGTGTCTTGGAGCCAACTAGAGGCAGGGTCATCCTTGCCCTTGTCCTCCCCT
TTCATCCCTATGTGGAAAACGGTGGCAAGTGGGAGAAACCATCAGAAATTTTGGAAATCAAAGGACAGAACTGGGAAGAACAAGTGAATA
GTCTGCCTGAAGTTTTCAGAAAAGCTGGTTTTGTTATCGAAGCTTTCACCAGACTACCATACCTGTGTGAAGGCGACATGTATAATGACT
ACTACGTTCTGGATGACGCTGTCTTTGTTCTCAAACCAGTATAAACACGTGGAGGTCGAAGTCTTCAGAGTCCGCACCCTCCGGGATGTG
CCCTTGGAAGAGGGTCTGTGTTCACAATTACGTGAAGGGAGGACCCTTGGGGACCGCCATTCTAAATATCATGTAGGAATTTAAAAAGCC
AAAATACTAATTATTTCTTTGTAGTGTGTAAAGGAATGTTTTTAAAAGACAAAAACCCAACTCTTTGTGGATTTTTATCAACTCTTTACT
CAGAGCCACTCTCCAATGCAGGTCACACTCCAATTATGATGGAAGATATTTTTTATACTTAATTGCAGTAGGGACTCATTCCCAGACAAA
GCAATAGTCACGACTTCATGGAACCAATCAATGGATTGTTTTTTGAAGACTGGCAATAAAGCTGTCCATTCAATTCCAAATACTGGTTTT
AAGGTATAGCCACTGATATTCTTTCATGTTTAGAAATTCTTTCTGTTATTATTCAAGAAAATGTTTTTAATCATGCTAATAAACTTTTTT
GGAGATGACTTTGGCATCATGTTTGAATTCATATAAAGCTCCCCTAGCATTTTTTATTGGTTTGGCTTCAGGAGTACCCAAATAGTAGCA
TTATGAGAATGACGCAGACAATTTGAATAGGGGGGAAGGAAGGCTTCAGACTTGGGGGAAGGGGAGATTATTGCAAATTGCAGTGAACAC

>27628_27628_6_ETFA-METTL9_ETFA_chr15_76603691_ENST00000559602_METTL9_chr16_21623966_ENST00000396014_length(amino acids)=275AA_BP=13
MFRAAAPGQLRRAWYVCNREKLCESLQAVFVQSYLDQGTQIFLNNSIEKSGWLFIQLYHSFVSSVFSLFMSRTSINGLLGRGSMFVFSPD
QFQRLLKINPDWKTHRLLDLGAGDGEVTKIMSPHFEEIYATELSETMIWQLQKKKYRVLGINEWQNTGFQYDVISCLNLLDRCDQPLTLL
KDIRSVLEPTRGRVILALVLPFHPYVENGGKWEKPSEILEIKGQNWEEQVNSLPEVFRKAGFVIEAFTRLPYLCEGDMYNDYYVLDDAVF

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ETFA-METTL9


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ETFA-METTL9


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ETFA-METTL9


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource