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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
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Fusion gene:ETHE1-CEACAM1 (FusionGDB2 ID:27646)

Fusion Gene Summary for ETHE1-CEACAM1

Fusion gene summary

Fusion gene information	Fusion gene name: ETHE1-CEACAM1
	Fusion gene ID: 27646
		Hgene	Tgene
	Gene symbol	ETHE1	CEACAM1
	Gene ID	23474	634
	Gene name	ETHE1 persulfide dioxygenase	CEA cell adhesion molecule 1
	Synonyms	HSCO\|YF13H12	BGP\|BGP1\|BGPI
	Cytomap	19q13.31	19q13.2
	Type of gene	protein-coding	protein-coding
	Description	persulfide dioxygenase ETHE1, mitochondrialethylmalonic encephalopathy 1hepatoma subtracted clone one proteinprotein ETHE1, mitochondrialsulfur dioxygenase ETHE1	carcinoembryonic antigen-related cell adhesion molecule 1CD66a antigenantigen CD66carcinoembryonic antigen related cell adhesion molecule 1carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
	Modification date	20200313	20200313
	UniProtAcc	O95571	P13688
	Ensembl transtripts involved in fusion gene	ENST00000292147, ENST00000600651,	ENST00000308072, ENST00000403444, ENST00000403461, ENST00000599389, ENST00000358394, ENST00000488639, ENST00000351134, ENST00000161559, ENST00000352591,
Fusion gene scores	* DoF score	10 X 7 X 8=560	3 X 2 X 3=18
	# samples	11	3
	** MAII score	log2(11/560*10)=-2.34792330342031 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: ETHE1 [Title/Abstract] AND CEACAM1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ETHE1(44030353)-CEACAM1(43013380), # samples:1
Anticipated loss of major functional domain due to fusion event.	ETHE1-CEACAM1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. ETHE1-CEACAM1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. ETHE1-CEACAM1 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ETHE1	GO:0006749	glutathione metabolic process	23144459
Hgene	ETHE1	GO:0070813	hydrogen sulfide metabolic process	23144459
Tgene	CEACAM1	GO:0001915	negative regulation of T cell mediated cytotoxicity	18424730
Tgene	CEACAM1	GO:0030334	regulation of cell migration	16291724
Tgene	CEACAM1	GO:0043318	negative regulation of cytotoxic T cell degranulation	18424730
Tgene	CEACAM1	GO:0044319	wound healing, spreading of cells	16291724
Tgene	CEACAM1	GO:0050860	negative regulation of T cell receptor signaling pathway	18424730

Fusion gene breakpoints across ETHE1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CEACAM1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	Non-Cancer	TCGA-CG-5734-11A	ETHE1	chr19	44030353	-	CEACAM1	chr19	43013380	-

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Fusion Gene ORF analysis for ETHE1-CEACAM1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000292147	ENST00000308072	ETHE1	chr19	44030353	-	CEACAM1	chr19	43013380	-
5CDS-3UTR	ENST00000292147	ENST00000403444	ETHE1	chr19	44030353	-	CEACAM1	chr19	43013380	-
5CDS-3UTR	ENST00000292147	ENST00000403461	ETHE1	chr19	44030353	-	CEACAM1	chr19	43013380	-
5CDS-3UTR	ENST00000292147	ENST00000599389	ETHE1	chr19	44030353	-	CEACAM1	chr19	43013380	-
5CDS-3UTR	ENST00000600651	ENST00000308072	ETHE1	chr19	44030353	-	CEACAM1	chr19	43013380	-
5CDS-3UTR	ENST00000600651	ENST00000403444	ETHE1	chr19	44030353	-	CEACAM1	chr19	43013380	-
5CDS-3UTR	ENST00000600651	ENST00000403461	ETHE1	chr19	44030353	-	CEACAM1	chr19	43013380	-
5CDS-3UTR	ENST00000600651	ENST00000599389	ETHE1	chr19	44030353	-	CEACAM1	chr19	43013380	-
5CDS-5UTR	ENST00000292147	ENST00000358394	ETHE1	chr19	44030353	-	CEACAM1	chr19	43013380	-
5CDS-5UTR	ENST00000292147	ENST00000488639	ETHE1	chr19	44030353	-	CEACAM1	chr19	43013380	-
5CDS-5UTR	ENST00000600651	ENST00000358394	ETHE1	chr19	44030353	-	CEACAM1	chr19	43013380	-
5CDS-5UTR	ENST00000600651	ENST00000488639	ETHE1	chr19	44030353	-	CEACAM1	chr19	43013380	-
Frame-shift	ENST00000292147	ENST00000351134	ETHE1	chr19	44030353	-	CEACAM1	chr19	43013380	-
Frame-shift	ENST00000600651	ENST00000351134	ETHE1	chr19	44030353	-	CEACAM1	chr19	43013380	-
In-frame	ENST00000292147	ENST00000161559	ETHE1	chr19	44030353	-	CEACAM1	chr19	43013380	-
In-frame	ENST00000292147	ENST00000352591	ETHE1	chr19	44030353	-	CEACAM1	chr19	43013380	-
In-frame	ENST00000600651	ENST00000161559	ETHE1	chr19	44030353	-	CEACAM1	chr19	43013380	-
In-frame	ENST00000600651	ENST00000352591	ETHE1	chr19	44030353	-	CEACAM1	chr19	43013380	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000292147	ETHE1	chr19	44030353	-	ENST00000352591	CEACAM1	chr19	43013380	-	2367	442	67	561	164
ENST00000292147	ETHE1	chr19	44030353	-	ENST00000161559	CEACAM1	chr19	43013380	-	2365	442	67	561	164
ENST00000600651	ETHE1	chr19	44030353	-	ENST00000352591	CEACAM1	chr19	43013380	-	2324	399	24	518	164
ENST00000600651	ETHE1	chr19	44030353	-	ENST00000161559	CEACAM1	chr19	43013380	-	2322	399	24	518	164

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000292147	ENST00000352591	ETHE1	chr19	44030353	-	CEACAM1	chr19	43013380	-	0.02555488	0.9744451
ENST00000292147	ENST00000161559	ETHE1	chr19	44030353	-	CEACAM1	chr19	43013380	-	0.026005724	0.9739943
ENST00000600651	ENST00000352591	ETHE1	chr19	44030353	-	CEACAM1	chr19	43013380	-	0.016139222	0.98386085
ENST00000600651	ENST00000161559	ETHE1	chr19	44030353	-	CEACAM1	chr19	43013380	-	0.016488949	0.9835111

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Fusion Genomic Features for ETHE1-CEACAM1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ETHE1-CEACAM1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:44030353/chr19:43013380)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ETHE1 O95571	CEACAM1 P13688
FUNCTION: Sulfur dioxygenase that plays an essential role in hydrogen sulfide catabolism in the mitochondrial matrix. Hydrogen sulfide (H(2)S) is first oxidized by SQRDL, giving rise to cysteine persulfide residues. ETHE1 consumes molecular oxygen to catalyze the oxidation of the persulfide, once it has been transferred to a thiophilic acceptor, such as glutathione (R-SSH). Plays an important role in metabolic homeostasis in mitochondria by metabolizing hydrogen sulfide and preventing the accumulation of supraphysiological H(2)S levels that have toxic effects, due to the inhibition of cytochrome c oxidase. First described as a protein that can shuttle between the nucleus and the cytoplasm and suppress p53-induced apoptosis by sequestering the transcription factor RELA/NFKB3 in the cytoplasm and preventing its accumulation in the nucleus (PubMed:12398897). {ECO:0000269\|PubMed:12398897, ECO:0000269\|PubMed:14732903, ECO:0000269\|PubMed:19136963, ECO:0000269\|PubMed:23144459}.	FUNCTION: [Isoform 1]: Cell adhesion protein that mediates homophilic cell adhesion in a calcium-independent manner (By similarity). Plays a role as coinhibitory receptor in immune response, insulin action and functions also as an activator during angiogenesis (PubMed:18424730, PubMed:23696226, PubMed:25363763). Its coinhibitory receptor function is phosphorylation- and PTPN6 -dependent, which in turn, suppress signal transduction of associated receptors by dephosphorylation of their downstream effectors. Plays a role in immune response, of T cells, natural killer (NK) and neutrophils (PubMed:18424730, PubMed:23696226). Upon TCR/CD3 complex stimulation, inhibits TCR-mediated cytotoxicity by blocking granule exocytosis by mediating homophilic binding to adjacent cells, allowing interaction with and phosphorylation by LCK and interaction with the TCR/CD3 complex which recruits PTPN6 resulting in dephosphorylation of CD247 and ZAP70 (PubMed:18424730). Also inhibits T cell proliferation and cytokine production through inhibition of JNK cascade and plays a crucial role in regulating autoimmunity and anti-tumor immunity by inhibiting T cell through its interaction with HAVCR2 (PubMed:25363763). Upon natural killer (NK) cells activation, inhibit KLRK1-mediated cytolysis of CEACAM1-bearing tumor cells by trans-homophilic interactions with CEACAM1 on the target cell and lead to cis-interaction between CEACAM1 and KLRK1, allowing PTPN6 recruitment and then VAV1 dephosphorylation (PubMed:23696226). Upon neutrophils activation negatively regulates IL1B production by recruiting PTPN6 to a SYK-TLR4-CEACAM1 complex, that dephosphorylates SYK, reducing the production of reactive oxygen species (ROS) and lysosome disruption, which in turn, reduces the activity of the inflammasome. Downregulates neutrophil production by acting as a coinhibitory receptor for CSF3R by downregulating the CSF3R-STAT3 pathway through recruitment of PTPN6 that dephosphorylates CSF3R (By similarity). Also regulates insulin action by promoting INS clearance and regulating lipogenesis in liver through regulating insulin signaling (By similarity). Upon INS stimulation, undergoes phosphorylation by INSR leading to INS clearance by increasing receptor-mediated insulin endocytosis. This inernalization promotes interaction with FASN leading to receptor-mediated insulin degradation and to reduction of FASN activity leading to negative regulation of fatty acid synthesis. INSR-mediated phosphorylation also provokes a down-regulation of cell proliferation through SHC1 interaction resulting in decrease coupling of SHC1 to the MAPK3/ERK1-MAPK1/ERK2 and phosphatidylinositol 3-kinase pathways (By similarity). Functions as activator in angiogenesis by promoting blood vessel remodeling through endothelial cell differentiation and migration and in arteriogenesis by increasing the number of collateral arteries and collateral vessel calibers after ischemia. Also regulates vascular permeability through the VEGFR2 signaling pathway resulting in control of nitric oxide production (By similarity). Downregulates cell growth in response to EGF through its interaction with SHC1 that mediates interaction with EGFR resulting in decrease coupling of SHC1 to the MAPK3/ERK1-MAPK1/ERK2 pathway (By similarity). Negatively regulates platelet aggregation by decreasing platelet adhesion on type I collagen through the GPVI-FcRgamma complex (By similarity). Inhibits cell migration and cell scattering through interaction with FLNA; interfers with the interaction of FLNA with RALA (PubMed:16291724). Mediates bile acid transport activity in a phosphorylation dependent manner (By similarity). Negatively regulates osteoclastogenesis (By similarity). {ECO:0000250\|UniProtKB:P16573, ECO:0000250\|UniProtKB:P31809, ECO:0000269\|PubMed:16291724, ECO:0000269\|PubMed:18424730, ECO:0000269\|PubMed:23696226, ECO:0000269\|PubMed:25363763}.; FUNCTION: [Isoform 8]: Cell adhesion protein that mediates homophilic cell adhesion in a calcium-independent manner (By similarity). Promotes populations of T cells regulating IgA production and secretion associated with control of the commensal microbiota and resistance to enteropathogens (By similarity). {ECO:0000250\|UniProtKB:P16573, ECO:0000250\|UniProtKB:P31809}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

CEACAM1

chr19:44030353

chr19:43013380

ENST00000351134

237_317

213

253.0

Domain

Ig-like C2-type 2

Tgene

CEACAM1

chr19:44030353

chr19:43013380

ENST00000351134

323_413

213

253.0

Domain

Ig-like C2-type 3

Tgene

CEACAM1

chr19:44030353

chr19:43013380

ENST00000351134

453_526

213

253.0

Topological domain

Cytoplasmic

Tgene

CEACAM1

chr19:44030353

chr19:43013380

ENST00000352591

453_526

391

431.0

Topological domain

Cytoplasmic

Tgene

CEACAM1

chr19:44030353

chr19:43013380

ENST00000358394

453_526

422

462.0

Topological domain

Cytoplasmic

Tgene

CEACAM1

chr19:44030353

chr19:43013380

ENST00000403461

453_526

373

282.0

Topological domain

Cytoplasmic

Tgene

CEACAM1

chr19:44030353

chr19:43013380

ENST00000599389

453_526

404

241.0

Topological domain

Cytoplasmic

Tgene

CEACAM1

chr19:44030353

chr19:43013380

ENST00000351134

429_452

213

253.0

Transmembrane

Helical

Tgene

CEACAM1

chr19:44030353

chr19:43013380

ENST00000352591

429_452

391

431.0

Transmembrane

Helical

Tgene

CEACAM1

chr19:44030353

chr19:43013380

ENST00000358394

429_452

422

462.0

Transmembrane

Helical

Tgene

CEACAM1

chr19:44030353

chr19:43013380

ENST00000403461

429_452

373

282.0

Transmembrane

Helical

Tgene

CEACAM1

chr19:44030353

chr19:43013380

ENST00000599389

429_452

404

241.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

CEACAM1

chr19:44030353

chr19:43013380

ENST00000161559

145_232

487

527.0

Domain

Ig-like C2-type 1

Tgene

CEACAM1

chr19:44030353

chr19:43013380

ENST00000161559

237_317

487

527.0

Domain

Ig-like C2-type 2

Tgene

CEACAM1

chr19:44030353

chr19:43013380

ENST00000161559

323_413

487

527.0

Domain

Ig-like C2-type 3

Tgene

CEACAM1

chr19:44030353

chr19:43013380

ENST00000161559

35_142

487

527.0

Domain

Ig-like V-type

Tgene

CEACAM1

chr19:44030353

chr19:43013380

ENST00000351134

145_232

213

253.0

Domain

Ig-like C2-type 1

Tgene

CEACAM1

chr19:44030353

chr19:43013380

ENST00000351134

35_142

213

253.0

Domain

Ig-like V-type

Tgene

CEACAM1

chr19:44030353

chr19:43013380

ENST00000352591

145_232

391

431.0

Domain

Ig-like C2-type 1

Tgene

CEACAM1

chr19:44030353

chr19:43013380

ENST00000352591

237_317

391

431.0

Domain

Ig-like C2-type 2

Tgene

CEACAM1

chr19:44030353

chr19:43013380

ENST00000352591

323_413

391

431.0

Domain

Ig-like C2-type 3

Tgene

CEACAM1

chr19:44030353

chr19:43013380

ENST00000352591

35_142

391

431.0

Domain

Ig-like V-type

Tgene

CEACAM1

chr19:44030353

chr19:43013380

ENST00000358394

145_232

422

462.0

Domain

Ig-like C2-type 1

Tgene

CEACAM1

chr19:44030353

chr19:43013380

ENST00000358394

237_317

422

462.0

Domain

Ig-like C2-type 2

Tgene

CEACAM1

chr19:44030353

chr19:43013380

ENST00000358394

323_413

422

462.0

Domain

Ig-like C2-type 3

Tgene

CEACAM1

chr19:44030353

chr19:43013380

ENST00000358394

35_142

422

462.0

Domain

Ig-like V-type

Tgene

CEACAM1

chr19:44030353

chr19:43013380

ENST00000403444

145_232

469

938.0

Domain

Ig-like C2-type 1

Tgene

CEACAM1

chr19:44030353

chr19:43013380

ENST00000403444

237_317

469

938.0

Domain

Ig-like C2-type 2

Tgene

CEACAM1

chr19:44030353

chr19:43013380

ENST00000403444

323_413

469

938.0

Domain

Ig-like C2-type 3

Tgene

CEACAM1

chr19:44030353

chr19:43013380

ENST00000403444

35_142

469

938.0

Domain

Ig-like V-type

Tgene

CEACAM1

chr19:44030353

chr19:43013380

ENST00000403461

145_232

373

282.0

Domain

Ig-like C2-type 1

Tgene

CEACAM1

chr19:44030353

chr19:43013380

ENST00000403461

237_317

373

282.0

Domain

Ig-like C2-type 2

Tgene

CEACAM1

chr19:44030353

chr19:43013380

ENST00000403461

323_413

373

282.0

Domain

Ig-like C2-type 3

Tgene

CEACAM1

chr19:44030353

chr19:43013380

ENST00000403461

35_142

373

282.0

Domain

Ig-like V-type

Tgene

CEACAM1

chr19:44030353

chr19:43013380

ENST00000599389

145_232

404

241.0

Domain

Ig-like C2-type 1

Tgene

CEACAM1

chr19:44030353

chr19:43013380

ENST00000599389

237_317

404

241.0

Domain

Ig-like C2-type 2

Tgene

CEACAM1

chr19:44030353

chr19:43013380

ENST00000599389

323_413

404

241.0

Domain

Ig-like C2-type 3

Tgene

CEACAM1

chr19:44030353

chr19:43013380

ENST00000599389

35_142

404

241.0

Domain

Ig-like V-type

Tgene

CEACAM1

chr19:44030353

chr19:43013380

ENST00000161559

39_142

487

527.0

Region

Required for homophilic binding

Tgene

CEACAM1

chr19:44030353

chr19:43013380

ENST00000351134

39_142

213

253.0

Region

Required for homophilic binding

Tgene

CEACAM1

chr19:44030353

chr19:43013380

ENST00000352591

39_142

391

431.0

Region

Required for homophilic binding

Tgene

CEACAM1

chr19:44030353

chr19:43013380

ENST00000358394

39_142

422

462.0

Region

Required for homophilic binding

Tgene

CEACAM1

chr19:44030353

chr19:43013380

ENST00000403444

39_142

469

938.0

Region

Required for homophilic binding

Tgene

CEACAM1

chr19:44030353

chr19:43013380

ENST00000403461

39_142

373

282.0

Region

Required for homophilic binding

Tgene

CEACAM1

chr19:44030353

chr19:43013380

ENST00000599389

39_142

404

241.0

Region

Required for homophilic binding

Tgene

CEACAM1

chr19:44030353

chr19:43013380

ENST00000161559

35_428

487

527.0

Topological domain

Extracellular

Tgene

CEACAM1

chr19:44030353

chr19:43013380

ENST00000161559

453_526

487

527.0

Topological domain

Cytoplasmic

Tgene

CEACAM1

chr19:44030353

chr19:43013380

ENST00000351134

35_428

213

253.0

Topological domain

Extracellular

Tgene

CEACAM1

chr19:44030353

chr19:43013380

ENST00000352591

35_428

391

431.0

Topological domain

Extracellular

Tgene

CEACAM1

chr19:44030353

chr19:43013380

ENST00000358394

35_428

422

462.0

Topological domain

Extracellular

Tgene

CEACAM1

chr19:44030353

chr19:43013380

ENST00000403444

35_428

469

938.0

Topological domain

Extracellular

Tgene

CEACAM1

chr19:44030353

chr19:43013380

ENST00000403444

453_526

469

938.0

Topological domain

Cytoplasmic

Tgene

CEACAM1

chr19:44030353

chr19:43013380

ENST00000403461

35_428

373

282.0

Topological domain

Extracellular

Tgene

CEACAM1

chr19:44030353

chr19:43013380

ENST00000599389

35_428

404

241.0

Topological domain

Extracellular

Tgene

CEACAM1

chr19:44030353

chr19:43013380

ENST00000161559

429_452

487

527.0

Transmembrane

Helical

Tgene

CEACAM1

chr19:44030353

chr19:43013380

ENST00000403444

429_452

469

938.0

Transmembrane

Helical

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Fusion Gene Sequence for ETHE1-CEACAM1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>27646_27646_1_ETHE1-CEACAM1_ETHE1_chr19_44030353_ENST00000292147_CEACAM1_chr19_43013380_ENST00000161559_length(transcript)=2365nt_BP=442nt
AGTGCCGTAGCGCCCGGCTCCTGCAGGCGCTCGGCCTCCGCTCATTCCTGACCCCGCAGTGGGCGCGATGGCGGAGGCTGTACTGAGGGT
CGCCCGGCGGCAGCTGAGCCAGCGCGGCGGGTCTGGAGCCCCCATCCTCCTGCGGCAGATGTTCGAGCCTGTGAGCTGCACCTTCACGTA
CCTGCTGGGTGACAGAGAGTCCCGGGAGGCCGTTCTGATCGACCCAGTCCTGGAAACAGCGCCTCGGGATGCCCAGCTGATCAAGGAGCT
GGGGCTGCGGCTGCTCTATGCTGTGAATACCCACTGCCACGCGGACCACATTACAGGCTCGGGGCTGCTCCGTTCCCTCCTCCCTGGCTG
CCAGTCTGTCATCTCCCGCCTTAGTGGGGCCCAGGCTGACTTACACATTGAGGATGGAGACTCCATCCGCTTCGGGCGCTTCATGAATGA
AGTTACTTATTCTACCCTGAACTTTGAAGCCCAGCAACCCACACAACCAACTTCAGCCTCCCCATCCCTAACAGCCACAGAAATAATTTA
TTCAGAAGTAAAAAAGCAGTAATGAAACCTGTCCTGCTCACTGCAGTGCTGATGTATTTCAAGTCTCTCACCCTCATCACTAGGAGATTC
CTTTCCCCTGTAGGGGTAGAGGGGTGGGGACAGAAACAACTTTCTCCTACTCTTCCTTCCTAATAGGCATCTCCAGGCTGCCTGGTCACT
GCCCCTCTCTCAGTGTCAATAGATGAAAGTACATTGGGAGTCTGTAGGAAACCCAACCTTCTTGTCATTGAAATTTGGCAAAGCTGACTT
TGGGAAAGAGGGACCAGAACTTCCCCTCCCTTCCCCTTTTCCCAACCTGGACTTGTTTTAAACTTGCCTGTTCAGAGCACTCATTCCTTC
CCACCCCCAGTCCTGTCCTATCACTCTAATTCGGATTTGCCATAGCCTTGAGGTTATGTCCTTTTCCATTAAGTACATGTGCCAGGAAAC
AAGAGAGAGAGAAAGTAAAGGCAGTAATGCCTTCTCCTATTTCTCCAAAGCCTTGTGTGAACTCACCAAACACAAGAAAATCAAATATAT
AACCAATAGTGAAATGCCACACCTTTGTCCACTGTCAGGGTTGTCTACCTGTAGGATCAGGGTCTAAGCACCTTGGTGCTTAGCTAGAAT
ACCACCTAATCCTTCTGGCAAGCCTGTCTTCAGAGAACCCACTAGAAGCAACTAGGAAAATCACTTGCCAAAATCCAAGGCAATTCCTGA
TGGAAAATGCAAAAGCACATATATGTTTTAATATCTTTATGGGCTCTGTTCAAGGCAGTGCTGAGAGGGAGGGGTTATAGCTTCAGGAGG
GAACCAGCTTCTGATAAACACAATCTGCTAGGAACTTGGGAAAGGAATCAGAGAGCTGCCCTTCAGCGATTATTTAAATTATTGTTAAAG
AATACACAATTTGGGGTATTGGGATTTTTCTCCTTTTCTCTGAGACATTCCACCATTTTAATTTTTGTAACTGCTTATTTATGTGAAAAG
GGTTATTTTTACTTAGCTTAGCTATGTCAGCCAATCCGATTGCCTTAGGTGAAAGAAACCACCGAAATCCCTCAGGTCCCTTGGTCAGGA
GCCTCTCAAGATTTTTTTTGTCAGAGGCTCCAAATAGAAAATAAGAAAAGGTTTTCTTCATTCATGGCTAGAGCTAGATTTAACTCAGTT
TCTAGGCACCTCAGACCAATCATCAACTACCATTCTATTCCATGTTTGCACCTGTGCATTTTCTGTTTGCCCCCATTCACTTTGTCAGGA
AACCTTGGCCTCTGCTAAGGTGTATTTGGTCCTTGAGAAGTGGGAGCACCCTACAGGGACACTATCACTCATGCTGGTGGCATTGTTTAC
AGCTAGAAAGCTGCACTGGTGCTAATGCCCCTTGGGGAAATGGGGCTGTGAGGAGGAGGATTATAACTTAGGCCTAGCCTCTTTTAACAG
CCTCTGAAATTTATCTTTTCTTCTATGGGGTCTATAAATGTATCTTATAATAAAAAGGAAGGACAGGAGGAAGACAGGCAAATGTACTTC
TCACCCAGTCTTCTACACAGATGGAATCTCTTTGGGGCTAAGAGAAAGGTTTTATTCTATATTGCTTACCTGATCTCATGTTAGGCCTAA
GAGGCTTTCTCCAGGAGGATTAGCTTGGAGTTCTCTATACTCAGGTACCTCTTTCAGGGTTTTCTAACCCTGACACGGACTGTGCATACT
TTCCCTCATCCATGCTGTGCTGTGTTATTTAATTTTTCCTGGCTAAGATCATGTCTGAATTATGTATGAAAATTATTCTATGTTTTTATA

>27646_27646_1_ETHE1-CEACAM1_ETHE1_chr19_44030353_ENST00000292147_CEACAM1_chr19_43013380_ENST00000161559_length(amino acids)=164AA_BP=125
MAEAVLRVARRQLSQRGGSGAPILLRQMFEPVSCTFTYLLGDRESREAVLIDPVLETAPRDAQLIKELGLRLLYAVNTHCHADHITGSGL

--------------------------------------------------------------
>27646_27646_2_ETHE1-CEACAM1_ETHE1_chr19_44030353_ENST00000292147_CEACAM1_chr19_43013380_ENST00000352591_length(transcript)=2367nt_BP=442nt
AGTGCCGTAGCGCCCGGCTCCTGCAGGCGCTCGGCCTCCGCTCATTCCTGACCCCGCAGTGGGCGCGATGGCGGAGGCTGTACTGAGGGT
CGCCCGGCGGCAGCTGAGCCAGCGCGGCGGGTCTGGAGCCCCCATCCTCCTGCGGCAGATGTTCGAGCCTGTGAGCTGCACCTTCACGTA
CCTGCTGGGTGACAGAGAGTCCCGGGAGGCCGTTCTGATCGACCCAGTCCTGGAAACAGCGCCTCGGGATGCCCAGCTGATCAAGGAGCT
GGGGCTGCGGCTGCTCTATGCTGTGAATACCCACTGCCACGCGGACCACATTACAGGCTCGGGGCTGCTCCGTTCCCTCCTCCCTGGCTG
CCAGTCTGTCATCTCCCGCCTTAGTGGGGCCCAGGCTGACTTACACATTGAGGATGGAGACTCCATCCGCTTCGGGCGCTTCATGAATGA
AGTTACTTATTCTACCCTGAACTTTGAAGCCCAGCAACCCACACAACCAACTTCAGCCTCCCCATCCCTAACAGCCACAGAAATAATTTA
TTCAGAAGTAAAAAAGCAGTAATGAAACCTGTCCTGCTCACTGCAGTGCTGATGTATTTCAAGTCTCTCACCCTCATCACTAGGAGATTC
CTTTCCCCTGTAGGGGTAGAGGGGTGGGGACAGAAACAACTTTCTCCTACTCTTCCTTCCTAATAGGCATCTCCAGGCTGCCTGGTCACT
GCCCCTCTCTCAGTGTCAATAGATGAAAGTACATTGGGAGTCTGTAGGAAACCCAACCTTCTTGTCATTGAAATTTGGCAAAGCTGACTT
TGGGAAAGAGGGACCAGAACTTCCCCTCCCTTCCCCTTTTCCCAACCTGGACTTGTTTTAAACTTGCCTGTTCAGAGCACTCATTCCTTC
CCACCCCCAGTCCTGTCCTATCACTCTAATTCGGATTTGCCATAGCCTTGAGGTTATGTCCTTTTCCATTAAGTACATGTGCCAGGAAAC
AAGAGAGAGAGAAAGTAAAGGCAGTAATGCCTTCTCCTATTTCTCCAAAGCCTTGTGTGAACTCACCAAACACAAGAAAATCAAATATAT
AACCAATAGTGAAATGCCACACCTTTGTCCACTGTCAGGGTTGTCTACCTGTAGGATCAGGGTCTAAGCACCTTGGTGCTTAGCTAGAAT
ACCACCTAATCCTTCTGGCAAGCCTGTCTTCAGAGAACCCACTAGAAGCAACTAGGAAAATCACTTGCCAAAATCCAAGGCAATTCCTGA
TGGAAAATGCAAAAGCACATATATGTTTTAATATCTTTATGGGCTCTGTTCAAGGCAGTGCTGAGAGGGAGGGGTTATAGCTTCAGGAGG
GAACCAGCTTCTGATAAACACAATCTGCTAGGAACTTGGGAAAGGAATCAGAGAGCTGCCCTTCAGCGATTATTTAAATTATTGTTAAAG
AATACACAATTTGGGGTATTGGGATTTTTCTCCTTTTCTCTGAGACATTCCACCATTTTAATTTTTGTAACTGCTTATTTATGTGAAAAG
GGTTATTTTTACTTAGCTTAGCTATGTCAGCCAATCCGATTGCCTTAGGTGAAAGAAACCACCGAAATCCCTCAGGTCCCTTGGTCAGGA
GCCTCTCAAGATTTTTTTTGTCAGAGGCTCCAAATAGAAAATAAGAAAAGGTTTTCTTCATTCATGGCTAGAGCTAGATTTAACTCAGTT
TCTAGGCACCTCAGACCAATCATCAACTACCATTCTATTCCATGTTTGCACCTGTGCATTTTCTGTTTGCCCCCATTCACTTTGTCAGGA
AACCTTGGCCTCTGCTAAGGTGTATTTGGTCCTTGAGAAGTGGGAGCACCCTACAGGGACACTATCACTCATGCTGGTGGCATTGTTTAC
AGCTAGAAAGCTGCACTGGTGCTAATGCCCCTTGGGGAAATGGGGCTGTGAGGAGGAGGATTATAACTTAGGCCTAGCCTCTTTTAACAG
CCTCTGAAATTTATCTTTTCTTCTATGGGGTCTATAAATGTATCTTATAATAAAAAGGAAGGACAGGAGGAAGACAGGCAAATGTACTTC
TCACCCAGTCTTCTACACAGATGGAATCTCTTTGGGGCTAAGAGAAAGGTTTTATTCTATATTGCTTACCTGATCTCATGTTAGGCCTAA
GAGGCTTTCTCCAGGAGGATTAGCTTGGAGTTCTCTATACTCAGGTACCTCTTTCAGGGTTTTCTAACCCTGACACGGACTGTGCATACT
TTCCCTCATCCATGCTGTGCTGTGTTATTTAATTTTTCCTGGCTAAGATCATGTCTGAATTATGTATGAAAATTATTCTATGTTTTTATA

>27646_27646_2_ETHE1-CEACAM1_ETHE1_chr19_44030353_ENST00000292147_CEACAM1_chr19_43013380_ENST00000352591_length(amino acids)=164AA_BP=125
MAEAVLRVARRQLSQRGGSGAPILLRQMFEPVSCTFTYLLGDRESREAVLIDPVLETAPRDAQLIKELGLRLLYAVNTHCHADHITGSGL

--------------------------------------------------------------
>27646_27646_3_ETHE1-CEACAM1_ETHE1_chr19_44030353_ENST00000600651_CEACAM1_chr19_43013380_ENST00000161559_length(transcript)=2322nt_BP=399nt
ATTCCTGACCCCGCAGTGGGCGCGATGGCGGAGGCTGTACTGAGGGTCGCCCGGCGGCAGCTGAGCCAGCGCGGCGGGTCTGGAGCCCCC
ATCCTCCTGCGGCAGATGTTCGAGCCTGTGAGCTGCACCTTCACGTACCTGCTGGGTGACAGAGAGTCCCGGGAGGCCGTTCTGATCGAC
CCAGTCCTGGAAACAGCGCCTCGGGATGCCCAGCTGATCAAGGAGCTGGGGCTGCGGCTGCTCTATGCTGTGAATACCCACTGCCACGCG
GACCACATTACAGGCTCGGGGCTGCTCCGTTCCCTCCTCCCTGGCTGCCAGTCTGTCATCTCCCGCCTTAGTGGGGCCCAGGCTGACTTA
CACATTGAGGATGGAGACTCCATCCGCTTCGGGCGCTTCATGAATGAAGTTACTTATTCTACCCTGAACTTTGAAGCCCAGCAACCCACA
CAACCAACTTCAGCCTCCCCATCCCTAACAGCCACAGAAATAATTTATTCAGAAGTAAAAAAGCAGTAATGAAACCTGTCCTGCTCACTG
CAGTGCTGATGTATTTCAAGTCTCTCACCCTCATCACTAGGAGATTCCTTTCCCCTGTAGGGGTAGAGGGGTGGGGACAGAAACAACTTT
CTCCTACTCTTCCTTCCTAATAGGCATCTCCAGGCTGCCTGGTCACTGCCCCTCTCTCAGTGTCAATAGATGAAAGTACATTGGGAGTCT
GTAGGAAACCCAACCTTCTTGTCATTGAAATTTGGCAAAGCTGACTTTGGGAAAGAGGGACCAGAACTTCCCCTCCCTTCCCCTTTTCCC
AACCTGGACTTGTTTTAAACTTGCCTGTTCAGAGCACTCATTCCTTCCCACCCCCAGTCCTGTCCTATCACTCTAATTCGGATTTGCCAT
AGCCTTGAGGTTATGTCCTTTTCCATTAAGTACATGTGCCAGGAAACAAGAGAGAGAGAAAGTAAAGGCAGTAATGCCTTCTCCTATTTC
TCCAAAGCCTTGTGTGAACTCACCAAACACAAGAAAATCAAATATATAACCAATAGTGAAATGCCACACCTTTGTCCACTGTCAGGGTTG
TCTACCTGTAGGATCAGGGTCTAAGCACCTTGGTGCTTAGCTAGAATACCACCTAATCCTTCTGGCAAGCCTGTCTTCAGAGAACCCACT
AGAAGCAACTAGGAAAATCACTTGCCAAAATCCAAGGCAATTCCTGATGGAAAATGCAAAAGCACATATATGTTTTAATATCTTTATGGG
CTCTGTTCAAGGCAGTGCTGAGAGGGAGGGGTTATAGCTTCAGGAGGGAACCAGCTTCTGATAAACACAATCTGCTAGGAACTTGGGAAA
GGAATCAGAGAGCTGCCCTTCAGCGATTATTTAAATTATTGTTAAAGAATACACAATTTGGGGTATTGGGATTTTTCTCCTTTTCTCTGA
GACATTCCACCATTTTAATTTTTGTAACTGCTTATTTATGTGAAAAGGGTTATTTTTACTTAGCTTAGCTATGTCAGCCAATCCGATTGC
CTTAGGTGAAAGAAACCACCGAAATCCCTCAGGTCCCTTGGTCAGGAGCCTCTCAAGATTTTTTTTGTCAGAGGCTCCAAATAGAAAATA
AGAAAAGGTTTTCTTCATTCATGGCTAGAGCTAGATTTAACTCAGTTTCTAGGCACCTCAGACCAATCATCAACTACCATTCTATTCCAT
GTTTGCACCTGTGCATTTTCTGTTTGCCCCCATTCACTTTGTCAGGAAACCTTGGCCTCTGCTAAGGTGTATTTGGTCCTTGAGAAGTGG
GAGCACCCTACAGGGACACTATCACTCATGCTGGTGGCATTGTTTACAGCTAGAAAGCTGCACTGGTGCTAATGCCCCTTGGGGAAATGG
GGCTGTGAGGAGGAGGATTATAACTTAGGCCTAGCCTCTTTTAACAGCCTCTGAAATTTATCTTTTCTTCTATGGGGTCTATAAATGTAT
CTTATAATAAAAAGGAAGGACAGGAGGAAGACAGGCAAATGTACTTCTCACCCAGTCTTCTACACAGATGGAATCTCTTTGGGGCTAAGA
GAAAGGTTTTATTCTATATTGCTTACCTGATCTCATGTTAGGCCTAAGAGGCTTTCTCCAGGAGGATTAGCTTGGAGTTCTCTATACTCA
GGTACCTCTTTCAGGGTTTTCTAACCCTGACACGGACTGTGCATACTTTCCCTCATCCATGCTGTGCTGTGTTATTTAATTTTTCCTGGC

>27646_27646_3_ETHE1-CEACAM1_ETHE1_chr19_44030353_ENST00000600651_CEACAM1_chr19_43013380_ENST00000161559_length(amino acids)=164AA_BP=125
MAEAVLRVARRQLSQRGGSGAPILLRQMFEPVSCTFTYLLGDRESREAVLIDPVLETAPRDAQLIKELGLRLLYAVNTHCHADHITGSGL

--------------------------------------------------------------
>27646_27646_4_ETHE1-CEACAM1_ETHE1_chr19_44030353_ENST00000600651_CEACAM1_chr19_43013380_ENST00000352591_length(transcript)=2324nt_BP=399nt
ATTCCTGACCCCGCAGTGGGCGCGATGGCGGAGGCTGTACTGAGGGTCGCCCGGCGGCAGCTGAGCCAGCGCGGCGGGTCTGGAGCCCCC
ATCCTCCTGCGGCAGATGTTCGAGCCTGTGAGCTGCACCTTCACGTACCTGCTGGGTGACAGAGAGTCCCGGGAGGCCGTTCTGATCGAC
CCAGTCCTGGAAACAGCGCCTCGGGATGCCCAGCTGATCAAGGAGCTGGGGCTGCGGCTGCTCTATGCTGTGAATACCCACTGCCACGCG
GACCACATTACAGGCTCGGGGCTGCTCCGTTCCCTCCTCCCTGGCTGCCAGTCTGTCATCTCCCGCCTTAGTGGGGCCCAGGCTGACTTA
CACATTGAGGATGGAGACTCCATCCGCTTCGGGCGCTTCATGAATGAAGTTACTTATTCTACCCTGAACTTTGAAGCCCAGCAACCCACA
CAACCAACTTCAGCCTCCCCATCCCTAACAGCCACAGAAATAATTTATTCAGAAGTAAAAAAGCAGTAATGAAACCTGTCCTGCTCACTG
CAGTGCTGATGTATTTCAAGTCTCTCACCCTCATCACTAGGAGATTCCTTTCCCCTGTAGGGGTAGAGGGGTGGGGACAGAAACAACTTT
CTCCTACTCTTCCTTCCTAATAGGCATCTCCAGGCTGCCTGGTCACTGCCCCTCTCTCAGTGTCAATAGATGAAAGTACATTGGGAGTCT
GTAGGAAACCCAACCTTCTTGTCATTGAAATTTGGCAAAGCTGACTTTGGGAAAGAGGGACCAGAACTTCCCCTCCCTTCCCCTTTTCCC
AACCTGGACTTGTTTTAAACTTGCCTGTTCAGAGCACTCATTCCTTCCCACCCCCAGTCCTGTCCTATCACTCTAATTCGGATTTGCCAT
AGCCTTGAGGTTATGTCCTTTTCCATTAAGTACATGTGCCAGGAAACAAGAGAGAGAGAAAGTAAAGGCAGTAATGCCTTCTCCTATTTC
TCCAAAGCCTTGTGTGAACTCACCAAACACAAGAAAATCAAATATATAACCAATAGTGAAATGCCACACCTTTGTCCACTGTCAGGGTTG
TCTACCTGTAGGATCAGGGTCTAAGCACCTTGGTGCTTAGCTAGAATACCACCTAATCCTTCTGGCAAGCCTGTCTTCAGAGAACCCACT
AGAAGCAACTAGGAAAATCACTTGCCAAAATCCAAGGCAATTCCTGATGGAAAATGCAAAAGCACATATATGTTTTAATATCTTTATGGG
CTCTGTTCAAGGCAGTGCTGAGAGGGAGGGGTTATAGCTTCAGGAGGGAACCAGCTTCTGATAAACACAATCTGCTAGGAACTTGGGAAA
GGAATCAGAGAGCTGCCCTTCAGCGATTATTTAAATTATTGTTAAAGAATACACAATTTGGGGTATTGGGATTTTTCTCCTTTTCTCTGA
GACATTCCACCATTTTAATTTTTGTAACTGCTTATTTATGTGAAAAGGGTTATTTTTACTTAGCTTAGCTATGTCAGCCAATCCGATTGC
CTTAGGTGAAAGAAACCACCGAAATCCCTCAGGTCCCTTGGTCAGGAGCCTCTCAAGATTTTTTTTGTCAGAGGCTCCAAATAGAAAATA
AGAAAAGGTTTTCTTCATTCATGGCTAGAGCTAGATTTAACTCAGTTTCTAGGCACCTCAGACCAATCATCAACTACCATTCTATTCCAT
GTTTGCACCTGTGCATTTTCTGTTTGCCCCCATTCACTTTGTCAGGAAACCTTGGCCTCTGCTAAGGTGTATTTGGTCCTTGAGAAGTGG
GAGCACCCTACAGGGACACTATCACTCATGCTGGTGGCATTGTTTACAGCTAGAAAGCTGCACTGGTGCTAATGCCCCTTGGGGAAATGG
GGCTGTGAGGAGGAGGATTATAACTTAGGCCTAGCCTCTTTTAACAGCCTCTGAAATTTATCTTTTCTTCTATGGGGTCTATAAATGTAT
CTTATAATAAAAAGGAAGGACAGGAGGAAGACAGGCAAATGTACTTCTCACCCAGTCTTCTACACAGATGGAATCTCTTTGGGGCTAAGA
GAAAGGTTTTATTCTATATTGCTTACCTGATCTCATGTTAGGCCTAAGAGGCTTTCTCCAGGAGGATTAGCTTGGAGTTCTCTATACTCA
GGTACCTCTTTCAGGGTTTTCTAACCCTGACACGGACTGTGCATACTTTCCCTCATCCATGCTGTGCTGTGTTATTTAATTTTTCCTGGC

>27646_27646_4_ETHE1-CEACAM1_ETHE1_chr19_44030353_ENST00000600651_CEACAM1_chr19_43013380_ENST00000352591_length(amino acids)=164AA_BP=125
MAEAVLRVARRQLSQRGGSGAPILLRQMFEPVSCTFTYLLGDRESREAVLIDPVLETAPRDAQLIKELGLRLLYAVNTHCHADHITGSGL

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Fusion Gene PPI Analysis for ETHE1-CEACAM1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Tgene	CEACAM1	chr19:44030353	chr19:43013380	ENST00000351134		4	6	450_462	213.0	253.0	calmodulin
Tgene	CEACAM1	chr19:44030353	chr19:43013380	ENST00000352591		6	8	450_462	391.0	431.0	calmodulin
Tgene	CEACAM1	chr19:44030353	chr19:43013380	ENST00000358394		7	9	450_462	422.0	462.0	calmodulin
Tgene	CEACAM1	chr19:44030353	chr19:43013380	ENST00000403461		5	7	450_462	373.3333333333333	282.0	calmodulin
Tgene	CEACAM1	chr19:44030353	chr19:43013380	ENST00000599389		6	8	450_462	404.3333333333333	241.0	calmodulin
Tgene	CEACAM1	chr19:44030353	chr19:43013380	ENST00000351134		4	6	452_526	213.0	253.0	FLNA
Tgene	CEACAM1	chr19:44030353	chr19:43013380	ENST00000352591		6	8	452_526	391.0	431.0	FLNA
Tgene	CEACAM1	chr19:44030353	chr19:43013380	ENST00000358394		7	9	452_526	422.0	462.0	FLNA
Tgene	CEACAM1	chr19:44030353	chr19:43013380	ENST00000403461		5	7	452_526	373.3333333333333	282.0	FLNA
Tgene	CEACAM1	chr19:44030353	chr19:43013380	ENST00000599389		6	8	452_526	404.3333333333333	241.0	FLNA

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Tgene	CEACAM1	chr19:44030353	chr19:43013380	ENST00000161559		7	9	450_462	487.0	527.0	calmodulin
Tgene	CEACAM1	chr19:44030353	chr19:43013380	ENST00000403444		6	8	450_462	469.3333333333333	938.0	calmodulin
Tgene	CEACAM1	chr19:44030353	chr19:43013380	ENST00000161559		7	9	452_526	487.0	527.0	FLNA
Tgene	CEACAM1	chr19:44030353	chr19:43013380	ENST00000403444		6	8	452_526	469.3333333333333	938.0	FLNA

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for ETHE1-CEACAM1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for ETHE1-CEACAM1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source