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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:ETV6-ABL2 (FusionGDB2 ID:27698) |
Fusion Gene Summary for ETV6-ABL2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ETV6-ABL2 | Fusion gene ID: 27698 | Hgene | Tgene | Gene symbol | ETV6 | ABL2 | Gene ID | 2120 | 27 |
| Gene name | ETS variant transcription factor 6 | ABL proto-oncogene 2, non-receptor tyrosine kinase | |
| Synonyms | TEL|TEL/ABL|THC5 | ABLL|ARG | |
| Cytomap | 12p13.2 | 1q25.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | transcription factor ETV6ETS translocation variant 6ETS variant 6ETS-related protein Tel1TEL1 oncogeneets variant gene 6 (TEL oncogene) | tyrosine-protein kinase ABL2Abelson tyrosine-protein kinase 2abelson-related gene proteinc-abl oncogene 2, non-receptor tyrosine kinasetyrosine-protein kinase ARGv-abl Abelson murine leukemia viral oncogene homolog 2 | |
| Modification date | 20200313 | 20200327 | |
| UniProtAcc | P41212 | P42684 | |
| Ensembl transtripts involved in fusion gene | ENST00000396373, ENST00000544715, | ENST00000344730, ENST00000367623, ENST00000392043, ENST00000408940, ENST00000504405, ENST00000507173, ENST00000511413, ENST00000512653, ENST00000502732, | |
| Fusion gene scores | * DoF score | 59 X 37 X 25=54575 | 12 X 13 X 3=468 |
| # samples | 58 | 13 | |
| ** MAII score | log2(58/54575*10)=-6.55604351475058 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(13/468*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ETV6 [Title/Abstract] AND ABL2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | |||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ETV6 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 10514502 |
| Tgene | ABL2 | GO:0018108 | peptidyl-tyrosine phosphorylation | 15886098 |
| Tgene | ABL2 | GO:0051353 | positive regulation of oxidoreductase activity | 12893824 |
| Fusion gene breakpoints across ETV6 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across ABL2 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerKB3 | . | . | ETV6 | chr12 | 12022903 | + | ABL2 | chr1 | 179102509 | - |
| ChimerKB4 | . | . | ETV6 | chr12 | 12022903 | + | ABL2 | chr1 | 179102509 | + |
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Fusion Gene ORF analysis for ETV6-ABL2 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000396373 | ENST00000344730 | ETV6 | chr12 | 12022903 | + | ABL2 | chr1 | 179102509 | - |
| 5CDS-intron | ENST00000396373 | ENST00000344730 | ETV6 | chr12 | 12022903 | + | ABL2 | chr1 | 179102509 | + |
| 5CDS-intron | ENST00000396373 | ENST00000367623 | ETV6 | chr12 | 12022903 | + | ABL2 | chr1 | 179102509 | - |
| 5CDS-intron | ENST00000396373 | ENST00000367623 | ETV6 | chr12 | 12022903 | + | ABL2 | chr1 | 179102509 | + |
| 5CDS-intron | ENST00000396373 | ENST00000392043 | ETV6 | chr12 | 12022903 | + | ABL2 | chr1 | 179102509 | - |
| 5CDS-intron | ENST00000396373 | ENST00000392043 | ETV6 | chr12 | 12022903 | + | ABL2 | chr1 | 179102509 | + |
| 5CDS-intron | ENST00000396373 | ENST00000408940 | ETV6 | chr12 | 12022903 | + | ABL2 | chr1 | 179102509 | - |
| 5CDS-intron | ENST00000396373 | ENST00000408940 | ETV6 | chr12 | 12022903 | + | ABL2 | chr1 | 179102509 | + |
| 5CDS-intron | ENST00000396373 | ENST00000504405 | ETV6 | chr12 | 12022903 | + | ABL2 | chr1 | 179102509 | - |
| 5CDS-intron | ENST00000396373 | ENST00000504405 | ETV6 | chr12 | 12022903 | + | ABL2 | chr1 | 179102509 | + |
| 5CDS-intron | ENST00000396373 | ENST00000507173 | ETV6 | chr12 | 12022903 | + | ABL2 | chr1 | 179102509 | - |
| 5CDS-intron | ENST00000396373 | ENST00000507173 | ETV6 | chr12 | 12022903 | + | ABL2 | chr1 | 179102509 | + |
| 5CDS-intron | ENST00000396373 | ENST00000511413 | ETV6 | chr12 | 12022903 | + | ABL2 | chr1 | 179102509 | - |
| 5CDS-intron | ENST00000396373 | ENST00000511413 | ETV6 | chr12 | 12022903 | + | ABL2 | chr1 | 179102509 | + |
| 5CDS-intron | ENST00000396373 | ENST00000512653 | ETV6 | chr12 | 12022903 | + | ABL2 | chr1 | 179102509 | - |
| 5CDS-intron | ENST00000396373 | ENST00000512653 | ETV6 | chr12 | 12022903 | + | ABL2 | chr1 | 179102509 | + |
| In-frame | ENST00000396373 | ENST00000502732 | ETV6 | chr12 | 12022903 | + | ABL2 | chr1 | 179102509 | - |
| In-frame | ENST00000396373 | ENST00000502732 | ETV6 | chr12 | 12022903 | + | ABL2 | chr1 | 179102509 | + |
| intron-3CDS | ENST00000544715 | ENST00000502732 | ETV6 | chr12 | 12022903 | + | ABL2 | chr1 | 179102509 | - |
| intron-3CDS | ENST00000544715 | ENST00000502732 | ETV6 | chr12 | 12022903 | + | ABL2 | chr1 | 179102509 | + |
| intron-intron | ENST00000544715 | ENST00000344730 | ETV6 | chr12 | 12022903 | + | ABL2 | chr1 | 179102509 | - |
| intron-intron | ENST00000544715 | ENST00000344730 | ETV6 | chr12 | 12022903 | + | ABL2 | chr1 | 179102509 | + |
| intron-intron | ENST00000544715 | ENST00000367623 | ETV6 | chr12 | 12022903 | + | ABL2 | chr1 | 179102509 | - |
| intron-intron | ENST00000544715 | ENST00000367623 | ETV6 | chr12 | 12022903 | + | ABL2 | chr1 | 179102509 | + |
| intron-intron | ENST00000544715 | ENST00000392043 | ETV6 | chr12 | 12022903 | + | ABL2 | chr1 | 179102509 | - |
| intron-intron | ENST00000544715 | ENST00000392043 | ETV6 | chr12 | 12022903 | + | ABL2 | chr1 | 179102509 | + |
| intron-intron | ENST00000544715 | ENST00000408940 | ETV6 | chr12 | 12022903 | + | ABL2 | chr1 | 179102509 | - |
| intron-intron | ENST00000544715 | ENST00000408940 | ETV6 | chr12 | 12022903 | + | ABL2 | chr1 | 179102509 | + |
| intron-intron | ENST00000544715 | ENST00000504405 | ETV6 | chr12 | 12022903 | + | ABL2 | chr1 | 179102509 | - |
| intron-intron | ENST00000544715 | ENST00000504405 | ETV6 | chr12 | 12022903 | + | ABL2 | chr1 | 179102509 | + |
| intron-intron | ENST00000544715 | ENST00000507173 | ETV6 | chr12 | 12022903 | + | ABL2 | chr1 | 179102509 | - |
| intron-intron | ENST00000544715 | ENST00000507173 | ETV6 | chr12 | 12022903 | + | ABL2 | chr1 | 179102509 | + |
| intron-intron | ENST00000544715 | ENST00000511413 | ETV6 | chr12 | 12022903 | + | ABL2 | chr1 | 179102509 | - |
| intron-intron | ENST00000544715 | ENST00000511413 | ETV6 | chr12 | 12022903 | + | ABL2 | chr1 | 179102509 | + |
| intron-intron | ENST00000544715 | ENST00000512653 | ETV6 | chr12 | 12022903 | + | ABL2 | chr1 | 179102509 | - |
| intron-intron | ENST00000544715 | ENST00000512653 | ETV6 | chr12 | 12022903 | + | ABL2 | chr1 | 179102509 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000396373 | ETV6 | chr12 | 12022903 | + | ENST00000502732 | ABL2 | chr1 | 179102509 | - | 13066 | 1283 | 274 | 4674 | 1466 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for ETV6-ABL2 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for ETV6-ABL2 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:/chr1:) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ETV6 | ABL2 |
| FUNCTION: Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. Plays a role in hematopoiesis and malignant transformation. {ECO:0000269|PubMed:25581430}. | FUNCTION: Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 acts also as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. {ECO:0000269|PubMed:15735735, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:18945674}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for ETV6-ABL2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >27698_27698_1_ETV6-ABL2_ETV6_chr12_12022903_ENST00000396373_ABL2_chr1_179102509_ENST00000502732_length(transcript)=13066nt_BP=1283nt GCGTCCCGGGTCCCCGCGCCGCGCCGCGACCTGCAGACCCCGCCGCCGCGCTCGGGCCCGTCTCCCACGCCCCCGCCGCCCCGCGCGCCC AACTCCGCCGGCCGCCCCGCCCCGCCCCGCGCGCTCCAGACCCCCGGGGCGGCTGCCGGGAGAGATGCTGGAAGAAACTTCTTAAATGAC CGCGTCTGGCTGGCCGTGGAGCCTTTCTGGGTTGGGGAGAGGAAAGGAAAGTGGAAAAAACCTGAGAACTTCCTGATCTCTCTCGCTGTG AGACATGTCTGAGACTCCTGCTCAGTGTAGCATTAAGCAGGAACGAATTTCATATACACCTCCAGAGAGCCCAGTGCCGAGTTACGCTTC CTCGACGCCACTTCATGTTCCAGTGCCTCGAGCGCTCAGGATGGAGGAAGACTCGATCCGCCTGCCTGCGCACCTGCGCTTGCAGCCAAT TTACTGGAGCAGGGATGACGTAGCCCAGTGGCTCAAGTGGGCTGAAAATGAGTTTTCTTTAAGGCCAATTGACAGCAACACGTTTGAAAT GAATGGCAAAGCTCTCCTGCTGCTGACCAAAGAGGACTTTCGCTATCGATCTCCTCATTCAGGTGATGTGCTCTATGAACTCCTTCAGCA TATTCTGAAGCAGAGGAAACCTCGGATTCTTTTTTCACCATTCTTCCACCCTGGAAACTCTATACACACACAGCCGGAGGTCATACTGCA TCAGAACCATGAAGAAGATAACTGTGTCCAGAGGACCCCCAGGCCATCCGTGGATAATGTGCACCATAACCCTCCCACCATTGAACTGTT GCACCGCTCCAGGTCACCTATCACGACAAATCACCGGCCTTCTCCTGACCCCGAGCAGCGGCCCCTCCGGTCCCCCCTGGACAACATGAT CCGCCGCCTCTCCCCGGCTGAGAGAGCTCAGGGACCCAGGCCGCACCAGGAGAACAACCACCAGGAGTCCTACCCTCTGTCAGTGTCTCC CATGGAGAATAATCACTGCCCAGCGTCCTCCGAGTCCCACCCGAAGCCATCCAGCCCCCGGCAGGAGAGCACACGCGTGATCCAGCTGAT GCCCAGCCCCATCATGCACCCTCTGATCCTGAACCCCCGGCACTCCGTGGATTTCAAACAGTCCAGGCTCTCCGAGGACGGGCTGCATAG GGAAGGGAAGCCCATCAACCTCTCTCATCGGGAAGACCTGGCTTACATGAACCACATCATGGTCTCTGTCTCCCCGCCTGAAGAGCACGC CATGCCCATTGGGAGAATAGCAGATCACTTTGCCAGCTGTGTGGAGGATGGATTTGAGGGAGACAAGACTGGAGGCAGTAGTCCAGAAGC TTTGCATCGTCCCTATGGTTGTGATGTTGAACCCCAGGCACTAAATGAGGCTATCAGGTGGAGCTCCAAGGAGAACTTGCTCGGAGCCAC TGAGAGTGACCCTAATCTCTTCGTTGCACTTTATGATTTTGTAGCAAGTGGTGATAACACACTCAGCATCACTAAAGGTGAAAAGCTACG AGTCCTTGGTTACAACCAGAATGGTGAGTGGAGTGAAGTTCGCTCTAAGAATGGGCAGGGCTGGGTGCCAAGCAACTACATCACCCCAGT GAACAGCCTGGAAAAACACTCCTGGTACCATGGACCTGTGTCACGCAGTGCAGCTGAGTATCTGCTCAGCAGTCTAATCAATGGCAGCTT CCTGGTGCGAGAAAGTGAGAGTAGCCCTGGGCAGCTGTCCATCTCGCTCAGGTACGAGGGACGTGTGTATCACTACAGGATCAATACCAC TGCAGATGGCAAGGTGTATGTGACTGCTGAGAGCCGCTTCAGCACCTTGGCAGAGCTTGTACACCATCACTCCACAGTGGCTGATGGGCT GGTGACAACATTACACTACCCAGCACCCAAGTGTAATAAGCCTACAGTCTATGGTGTGTCCCCCATCCACGACAAATGGGAAATGGAGCG AACAGATATTACCATGAAGCACAAACTTGGGGGCGGTCAGTATGGAGAGGTTTACGTTGGCGTCTGGAAGAAATACAGCCTTACAGTTGC TGTGAAAACATTGAAGGAAGATACCATGGAGGTAGAAGAATTCCTGAAAGAAGCTGCAGTAATGAAGGAAATCAAGCATCCTAATCTGGT ACAACTTTTAGGTGTGTGTACTTTGGAGCCACCATTTTACATTGTGACTGAATACATGCCATACGGGAATTTGCTGGATTACCTCCGAGA ATGCAACCGAGAAGAGGTGACTGCAGTTGTGCTGCTCTACATGGCCACTCAGATTTCTTCTGCAATGGAGTACTTAGAGAAGAAGAATTT CATCCATAGAGATCTTGCAGCTCGTAACTGCCTAGTGGGAGAAAACCATGTGGTAAAAGTGGCTGACTTTGGCTTAAGTAGATTGATGAC TGGAGACACTTATACTGCTCATGCTGGAGCCAAATTTCCTATTAAGTGGACAGCACCAGAGAGTCTTGCCTACAATACCTTCTCAATTAA ATCTGACGTCTGGGCTTTTGGGGTATTGTTGTGGGAAATTGCTACCTATGGAATGTCACCATATCCAGGTATTGACCTGTCTCAGGTCTA TGACCTACTAGAAAAAGGATATCGAATGGAACAGCCTGAGGGATGCCCCCCTAAGGTTTATGAACTTATGAGAGCATGCTGGAAGTGGAG CCCTGCCGATAGGCCCTCTTTTGCTGAAACACACCAAGCTTTTGAAACCATGTTCCATGACTCCAGCATTTCTGAAGAGGTAGCTGAGGA GCTTGGGAGAGCCGCCTCCTCGTCATCTGTTGTTCCATACCTGCCCCGGCTACCTATACTTCCTTCCAAGACTCGGACACTGAAGAAACA GGTGGAGAACAAGGAGAACATTGAAGGGGCACAAGATGCCACAGAAAATTCTGCTTCCAGTTTAGCACCAGGGTTCATCAGAGGTGCACA GGCCTCTAGTGGATCCCCAGCACTGCCTCGAAAGCAAAGAGACAAGTCACCCAGCAGCCTCTTGGAAGATGCCAAAGAGACATGCTTCAC CAGGGATAGGAAGGGGGGCTTCTTCAGCTCCTTCATGAAGAAGAGAAATGCTCCTACACCCCCCAAACGCAGCAGCTCCTTCCGAGAAAT GGAGAATCAGCCCCATAAGAAATACGAACTCACGGGTAACTTCTCATCTGTTGCTTCTCTACAGCATGCTGATGGGTTCTCTTTCACTCC TGCCCAGCAAGAGGCGAATCTGGTGCCACCCAAGTGCTATGGGGGGAGCTTTGCACAGAGGAACCTCTGTAATGACGACGGTGGTGGGGG TGGGGGCAGTGGCACTGCTGGGGGTGGGTGGTCTGGCATCACAGGCTTCTTTACACCACGCTTAATCAAAAAGACACTGGGCTTACGAGC AGGTAAACCCACAGCCAGTGATGACACTTCCAAGCCTTTTCCAAGGTCAAACTCTACATCTTCCATGTCCTCAGGGCTTCCAGAGCAGGA TAGGATGGCAATGACCCTTCCCAGGAACTGCCAGAGGTCCAAACTCCAGCTGGAAAGGACAGTGTCCACCTCTTCTCAGCCAGAAGAGAA TGTGGACAGGGCCAATGACATGCTTCCAAAAAAATCAGAGGAAAGTGCTGCTCCAAGCAGGGAGAGACCAAAAGCCAAGTTATTGCCCAG AGGAGCCACAGCTCTTCCTCTCAGAACACCCTCTGGGGATCTAGCCATTACAGAGAAGGACCCTCCAGGGGTGGGAGTGGCTGGAGTGGC AGCTGCCCCCAAGGGTAAAGAGAAGAATGGTGGGGCACGACTTGGGATGGCTGGAGTTCCAGAGGATGGAGAGCAGCCGGGCTGGCCTTC TCCAGCCAAGGCTGCCCCCGTCCTCCCAACCACTCACAACCACAAAGTGCCAGTCCTTATCTCACCCACTCTGAAACACACTCCAGCTGA CGTGCAGCTCATTGGCACAGACTCTCAGGGGAATAAATTCAAGCTCTTATCTGAGCATCAGGTCACATCCTCTGGAGACAAGGACCGACC CCGACGGGTAAAACCAAAGTGTGCCCCACCCCCACCACCAGTGATGAGACTACTGCAGCATCCGTCCATCTGCTCAGACCCTACAGAAGA GCCAACTGCCCTAACTGCAGGACAGTCCACATCAGAAACACAGGAAGGAGGAAAGAAGGCAGCTCTGGGCGCAGTGCCCATCAGTGGGAA AGCTGGGAGGCCAGTGATGCCTCCACCTCAAGTGCCTCTGCCCACATCTTCCATCTCGCCAGCCAAAATGGCCAATGGCACAGCAGGTAC TAAAGTGGCTCTGAGAAAAACCAAACAGGCCGCTGAGAAAATCTCAGCAGACAAAATCAGCAAAGAGGCCCTGCTGGAATGTGCTGACCT ACTGTCCAGTGCACTCACGGAACCTGTGCCCAACAGCCAGCTGGTAGACACTGGACACCAGCTGCTTGACTACTGCTCAGGCTATGTGGA CTGCATCCCTCAAACTCGCAACAAATTTGCCTTCCGAGAGGCTGTGAGCAAACTGGAACTCAGCCTGCAGGAGCTACAGGTTTCTTCAGC AGCTGCTGGTGTGCCCGGGACAAACCCTGTCCTTAATAACTTATTGTCATGTGTACAGGAAATCAGTGATGTGGTGCAGAGGTAGCCACT GTTAGCCTGGTGGGAAAATGCACACATTTCTGAGGGGAGAGGGAAAAGGACTTGTTTTCCTGTGTTCTTGTTTTCAGAAAATGAAAGACT CATACTTGAGTGTGTTTATGTGAAGTACCTCAGATCCCTGAGTTCTCACGTTTACAGTTTCATCTCAAAAATAAGAAGCAAACCACATAA GTATAGGAGAGGTAAATTAAGTGGGGGCAAGGCAGTAGTGGACAGGGTTGGAAACTGCACTGGAAAATAGGGAACATGTGTATGTCATAA GGAAGGCAATGCAGCCCATCCCTACCTGGAATGCTGGGAAGTGCTAGGCAGGGCTGCTCTCAGCAAGACTGCAGCAGCTGCACCCAGACC TGGGGCTCTGGTAGGTACTAATGGTGATTATGCTCCAATTTACCTAATGAATTTGGTGGGACAGCAGAAAAGAAAGCTGGGAATGTACCA AGAGAAATTTTTGTTCAGGGCTGTTGGAAGTAGCTGTTAGCCTTGCTTCCACAAGGCCATTGCTGCTGTAATAAGAACTGCAAATCAGAG TGCTACAACATAAAACTGGGAAATATGGCCCTATCTGAATGCCTCTGTCCTATTTTCCGCTGGTGTATCAGTTAGTGCAGGAAGTAAAGA ATGCTGGAAAGTTGAATCAGAAATTGAAAACCTTCTAAAATCTTACACAGATTAGCAGAAGTCACTTCTCCCAGTCTGGTATATTATTTC ATAATGGACCAGGATCGGCTTCCTGCCTGTTGGTGGCTATCTGTAAACCATAAGTACAGGGGTCTCCCTAGTGGTTCTTCTCTGTCTTTT GCTGGGCAGGCTGTCTTCCTTTATTCCTGGTAGCATTCAGAGCATTAACCAGTGTTGATTTTGAAAATAGTAGTCCCTACAGGTTCTCAC AAAGGAATGAATCCTGTTCTGATACAGTTCCCCTGCATACTGACATACTGGCCAAGGACTTGAGCAGCTGTGTATTTTTCTTTATCAACT AAAATACCAGGGAGATGGTCTTTTCTTGAAACCCAGTGGCCTGTATGTGACTGAGAGGAAAAGCTGGCTTGGTCCTAATGGCTGTTTCTC TGTACCTTTCCCTTCCCTTACCACCTTAAGCCCAATCCAGGTAGAGAATAGGGAGAGGCATTCTCCTCTCTATGGATTTGAAGTGAATCA CCCCCACATTATTCTCACATGCTTTTCTTCTCTCACATATTCCTCCCTACTCCCCCACCCAATCATTGTGCTTATTTGTACAGATCTTAT TGGGAATATTCTTTATTTATTTTGTCATTTCACTTCTATTTTAAGAATGCATAATTGAAGGAGTAGTCATTTTCAGGGAGCACCAGGTAG ACCCTGGGAACCTAATGACTTAATCCTTAAATATGTTTTGCCCTTGAAAAATAGGCCTTTTCCTTCCTTCCTTAGTTATAATTGTGGAAG CTAATTAGGATGGCATGGAAGTGAATCTAATGAGTTAGGTATTATTAATGTTCTTGGTATCGGGTCTAATTCCAGTTACTGCTTCATTCT CTTTTTAAAGCTTTATGAATACTTCCCCCATCCTCCCCAAGGAGAGCTCAATACACACATATTTTTATTTTATTCTCTCAAAGGAATATT AGCTTAGGAAGATAGGAATTCAACATTGAGCACTGAGTTTTCTTCTGGCTCTGTCATTGATACACTGTCAAACCACAGCCTCATCTCTTA ATCTATTTAATTAAGGTAACAGTACATGTTCTCAAGGGTGTTGCAAGTAAGTGTGCAGCTATCCCTTGGAGAGCCTCTCTGGAAAGCTCT TTTAGTGCAGTGTTGTTATGCTGAATTGTTTTCCATTATCTTATTTGCTGAGTAGAAAATATTAATGAAATTAAGAATTGTTGAGATTAT ATGAATTGGGCTAGAATACTAAGGGGAAAACTATGTTTTGAATAGAGTTTGGCATTTTTGACCAAGAACAAAATTGAGTTTTCATTGGAA AGAAAGGAAACCTTGATTCTTACCATTGCTGCTCCAAAGGAGGCCCAGGTTAAGAGGATTAGAGGAGACACGCGGTGCTGGGCATTCCTG GCAGGTGTTGGGTGATCCCCGCAGTATGTCACCTGCAGTTGCAGCACAGGCAGCTAGTGATTGGGTTCATCTCCTCCTAGTGGTTGGAAG AGAACTCAGATGTAAAAACCAGCGGTCCTTCTCCCACCTTCTTTCCTGCCATTCTTGCTCATCATACATGTCCGTAAACTTGAAGAACTC GTTTTAGCAGCTAGCCTTTTAAGGTCGAGGATGGGAAAGCTAAAACTGTAGAATATTATTATGCTGCTTTTTAGGTTTATCCCTGTTGTT GTGGGATGCAAGTTAAGGGATTGTAATTGTTTTTCAGGGTTTTTTTGTTTTTTGTTTTTTAAGCAAGGGCTCTATTTTCCCTTGAGAGTT CTGGAACTAAGCCTTGGAGAAACACTACTGAGTGTATTTAGGCTCCCTGGTTTTCTTGCCCAACAACAATCTGAAGGGTAGGGGGTGGGG GCTGTGTCTTACTCAGGGGCAGCACCTAGCTGTCTTGCCTACAGTGGGTGCACGATATATAAATGGAATTGATTTTTGTCAACACTGTCA AGAGTGGCATTGACTATTGGAGCATACCCCGTCCACATGATGCTTGAACTATGTAACTTCAGGGGTTGAGGGCTCAAGGTTCAGGTTAAA GAGGCACTGTCAACTTACTATACAAGCATAATTTAGGTTTTTCCTTTTTCTACTTGAAAAGGACCAGCTTAAACACAAACCCTTATGTAA ATTAAAAGGTTTGAATCCAAAGCAGAGAGAACTGCTTCTGGAAAAGTGTAGTTTAATTTTAACTATTCTAAAAGCAATGAGCAAAGGCCC TTGTCCAAGGCGTTGACAGTTTTCTAAAGTGGTTATGCTGTATATCTGGATGCATGCCTTTGGGCTGCCACTGCTTGATTCCTTTCATGT ACAGATAATATTACTTCAGTTTAGATTTCCCACTTTAAAATGCAGTGATTTGTGTTGAATACATCTTGATTGTGCTTTACCTAAAGTATT TTCTTAAAAGGCTTTGTGTAAAATTTAAATGTATATATTTTCCTGTAGACTTCCATCATGATTTTCAGAGATTAGCCTTAAAAAATTTGG CCCTAAGAAATTCATTCAGTGTTTTTCTAGATGACCTCTGTACATAGAGGTCATTATAGTGGAGACCCTTTACCAGCAGCATTTTAAGAT TTAAATTAGATAGAAAGTTTCTTAGGATTCAACTGAAAATTGGCTAGTAAAATATGTCCCAGGTAATAAAGCATGCTGACTTTGCTAAGG CACTGCCCATTTTTATTTAACTAAAGTCATGGAGATTTTGAGTTTAAAGGATGCAGTATAGATAGTGGTTTAGTGTTTAGGCTCTAATGC CAGTCTAAAAGGCAAGTCATTTAACCTTGGGAGCCTCAGTTTCCTCACTGTAAAACAGGGATAATAATAGTAACTACCTCAGGGTTGTTG TAAGGATTAAATGAGATGATATTTGTAAGATACTTAGCTCAAGTGCCTGGCACACAATGAGCACACTCTATAAATGTTCTACTACTACTA TTATTAACACCTAGTCTAGGGATGCACAGCAGAATCCCCTAGGGTTAAAAAACAAAACAAAACAAACAAAAAAAACTGACGGAATAGCCC CACTCCAGATCAGAATTCCCAGTGGGCTGGGGTCTCGGCCAGTGTATTCTCCAGTAATCTCGCCAGGTGTTTGAAACACCCAGTGCTATC TGAAAACTATCAGTACCCCAACCCTTTGGTTTATAGATTAAGAAACTAGCAGAAGATGGTTAAATTACTTGCCTATTGTCTCAGAACGGT TAATTAGTGGCGGAGCCAAGGCTAGAATTCAAGTCTCTTGACTTTATGGTTGTGGGGTCTTTCCACCATACCTGCTGCCATGTGAGACAC TGCAAAAAAGTGGCTCAGACCGACAATCAGCCTGTGTGGTGCTGCACACTTTCTAAAGCACATGCTCCTGACACTTTGACCTTAAGGGGC TTGAATGTGGAGTAATGGGAACACAAGCCAAGCAAGCACTCAGTAGAATTCAGTCATTTAAAAAATTCAATGGGGTCATTCTTTTGGACA GACCTCAGCAACACAGCAATGTGCACTTTGTAGTAAAGAAATACCAACTTGAGTTTTTAAAAAACCTAGTTAGTCCTACATTCCCTTTTC TTTAAAAAAACTTTATTGTTCACATTATTTTAATGACTATGAGATAATGTATATGACAGCACTTTGAGAAAATATCAACTGTAATATAAC TATAAGGTTGTAGTATTGTCTGTTTAAAAGATAAGACAGTTGATTCAATGTGGATGGACCCTGTGGGGTACCTGAAAATGTAGATACGTA AGAATCACCTCTGTCATTTATCACATTTAGAAATATGAAACTGCTTAACAGGTATGAGCAGGTATAGCAAGTGTTTGCTAAAGTTGTAGT TCAGAGCTGAATTACTTCAGGAAACTAGGGACCAACTTTTTGGTTTAATTCCGATCTTTAAAAAGTAAGAATGTGTACTCACTCCAGAAC ACAGAAGCTCTTCCAAGGACCTTGACTCAAGAAGGATGAGGTCCTCTTACTCTTCTCCATTTATCCACTATATGCTTGGCCATTTATCCT AAATGTGGTGGGAACAGACTTGTTATCTGTTGATGTTGACAGTGTCTTTTTTAACCTATGTCCTGCATAGTTTTGTTAGGTTTACAGGGG GAGGTGGATGGCCATAAAACCAGTGCACTTTGGGAATTACTTTTCTAGGATTTCCTACCAGTTATAAATGACATTGACATTTGTCATCTT TTTTTTCTTTTTCTAAAAAGAATAGCTGAATTTAATTCACCTATTATAAAATACTCAAAAGTAAATTGCCTTGGTGGCCACTTCTGAATT ATAGCTACATTTCATTATGACCCCTTCTGCTCCCTTCCATTTTGCTACTGATGTCATTCTTGTTATCAGGCTGTGCCCCTACCAGGAGTT CATATTGGGTTGACAGGGTTATCTATATTTTTGTTCTTGATTTTTGAGTTTCATCATCTTGCATTAAATTGTTCCACCTGGATTTGGGGT TCATCTCTGTGCCCTAAGGATCTGCTATGACCAATCCTCTTTTTGTAGGTGGGTCTCTGGCTTAAGTATTGATAGGCTTCAGCGGTTTGT GTCTCTGTCTTAGCTTGTATCAAGCCAGTAGTAGCTCACTTCCTTTGTAAATTCCTGCTTCAGTCTGGGATCCGTAGGAGTATGTGAGAA CTTCTGAAACGTCTCCAACTCTTAACAGTCAAGATATCTATATCATTTGGATAGAGTTCTGGTTTTCCAACTACTAGACTTAAAGAAATT CTGGCCGGGTGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGGGGCTGAGGCGGGTGGATCACGAGGTCAGGAGATTGAGACCATCC TGGCTAACACGGTGAAACCCCACCTCTACTAAAAATACAAAAACTTAGCTGGGCGTGGTGGCGGGCGCCTGTAGTCCCAGCTACTGGGGA GGCTGAGGCAGGAGAATGGCGTGAACCCAGGAGGCGGAGCTTGCAGTGAGCCCAGATCGCGCCACTGCACTCCAGCCTGGGTGACAGTGA GACTCCGTCTCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAGAAATTCTAATGCAAAGCTTGCTTTTTTTTTCTTTTTTCCAGCA AGCCAGTAGTAATAGTTATTGTTACTTGCTCTGTTCAGCACAACTGTAGTTCACTTGAACTTCACTGTCATTCCCTACGCTCCTCTCTTA CTGAGAAGCATGGGTGGGATTCAGGGCTGTGGGACAAGCTACAGCCTACTCTGGAGCACTCACCCCCATGACTCAGTCCAGCCTGTCTCT TGGGAAGTTTATTGCAATGTGCAGACGGATGAATTTCTGCTTTTCATGCCACCTCTCTGAGGTATGTATTCTATCTTGAGTATGTACAAG ATGATACCTTTTGGCTGGGCACAGTGGCTCGTGCCTGTAATCCCAGCACTTTGGGAGACCAAGATGGGCGGATCACTTGAGGTCAGGAGT TTGAGACCAGCCTGGCCAACATGGTGAAACCCCGTCTCTACTAAAAATATAAAAATTAGCCGGGCGTAGTACATGCCTGTAATCCCAGCT ACTCCCGAGGCTGAGGCAGAATTGCTTGAACCCAGGAGGCGGAGGTTGCAGTGAGCTGAGATCGCGCCGCTGCACTCCAGCCTAAGTGAC AGAGTGAGACACGTTAAGAAGAAAAAAAAAAAAAAGGATACCTTCATTTCTGACTCAATATCCTAGATCCAAAGGACAGGAAATTAGGGA AGGCTTCACCCTGTGGGATCAAGATAAGAAGATCCCATACTTCTTCCCAGGTAAGGAGGCCTGTGGCAGGTCATGATTCAAAGCTGACTT GGAATGGCAGAAACTGCTGAGAGGCCACCCTTGGAGATTTGTGCCTTCAAAGATGGGTTTCATGAGTCTCAGAGAGGAAAAGACTTGTCA GCTGGGTTGATTTTGCATGATTATTGAACTAGAGCTGGTAGACACGAGCTTCTCAGATGGCAGTGGCCAGATCCTCCATCTGTGAGAATC CGCCACTTGAAGTGGTTTCCTGAGAGTGTTCACTTGGCAGTTGCTGCGTTTCTCAAGCCCACCTGGCGAGGTCTCGCCGGACCCTTCCCT CCAAGTGCACTTACTTCTTCATCCCCATGTACATCTCTAACTTTGAAATTGTTTACCTCTCCTACAAAAATCTTACCTTTTGACCTGAGC AGAGTAGCAAAGCCCTGTTCACTCTGAGGGAGCAGCTGGCGTGTTGAAGGGGAAAGGCCAGGCACAGCACTGTCCTCAGACCACACCATA TTTGGAGCAGAATTGTGATACATGTCATCTGTGTCTATTCTGGAAGGTTCTTTGTTCATCACTGTACTCGCATCAGCAAATTTTCAGGGT CCTACCTGTCACTCCAGGCTACTGAGCTGAACCCTCAGAAGCTGAGGTCTCCGAGCATGCTAAGTAACCTTTTAGAAAAGCTGGAGGCAA ACTGTCGAATGCTAGCAGGCTTTATGAAAGGAAACATAAGGAGTTTGTGTAGTCAGAACTTGCTTAAATTTGCTTCGGAATTAGGCACCA TAAACTTTAGTTGGAGAATGGGACTTAAATTTTCACATATATGTATACTTAATTTTCAGCAATTATGACACAATAAAAAGAATATGCAAA TTTATTGTTGTTTCAGAAGGTTTTGCAGGACTGGGAACGCTTTAGTGTCATCAACAGTAAACCTCAGATACTGTTCTGCACAGTTCAGAA GTACCATACCAGGTATTGTGAGTGGCAAGAACGCCAGGGGACAGAGATGCTTCTGGTAGATGAGGGCCAGAGAAACCAGCTCTCCTCCAT TTTGACAGCAATTTCTCACTGTGGCCATTTGGCCTCCATTATGTTTTGAGAGGAATTTCTTGAGATCTTGAGAAATCACCATGATTAGGC CAATTGTCAATCAGTATTCAGAAACTAGAAAGGAACAATGAGATACTTGTTTATGGTTCTTTAGGGCATATGTTTGAAAACCCTCTCATC TCAGATCTGTATAGCTGGTGTGTGTTTGTGTCCATAAATACACGTGCATTGCTGTCGTGCCCATTAAGAAAGGGGGAGTAAGTAAAAGAG GAATCGCTCAGATCTTTCCTTGGATGAACAGCAGTGGCGTGGTTGGTGTGTTGACTGTGAACAGGCTGACTTAGCTGTTGATGTATACTC AGAACCTCCATCTCCTCCCAGACCCTGCACTTTTCCTTCTCTGCAGTCTGATTCTCTAATGACTGTCACTGGACAAACCCCAGTTTTATG CTCGCTTAGTAAAAATAAGTTTAAACATTTCATGGTGGTTGACAGAACTTTGTCCCCAAACATGCGGATTCAATTCTTTAAAACTCGTTG AACGTTTATACCAAAGGTCCCGCCCCGCAGGTGTGTATGTGGTGCACAGAGGGTGAGGTTTGGAGCATCGGGCACTGTGTGCATTGCTAA GGGGACATAGTGAGACAATGTGGGATTTAACTAAAAACACATCAATTGTGTGTCACATTACCAGTGTTGTCAGGTATTTGTTCTTAATTG TTATTGTAATATATTTTCAGTTGTTTTTCTAATTTAATTCTCTCCGTCTGTTGTCTGACTGTGAACTGCTAACAGTGTTAAACTTGATGT AAATAAATGAGGCCCTTGAAAGGGACTGCTTTCTCTGTCTTCTCACAAGGTTTGCCAAGTTGTGTTCTGTTTTAAATAAAGGTTGCAATA >27698_27698_1_ETV6-ABL2_ETV6_chr12_12022903_ENST00000396373_ABL2_chr1_179102509_ENST00000502732_length(amino acids)=1466AA_BP=336 MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDNCVQRTPRPSVDNVHHNPPTIELLH RSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSESHPKPSSPRQESTRVIQLMP SPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIADHFASCVEDGFEGDKTGGSSPEAL HRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVN SLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLV TTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQ LLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTG DTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSP ADRPSFAETHQAFETMFHDSSISEEVAEELGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDATENSASSLAPGFIRGAQA SSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFMKKRNAPTPPKRSSSFREMENQPHKKYELTGNFSSVASLQHADGFSFTPA QQEANLVPPKCYGGSFAQRNLCNDDGGGGGGSGTAGGGWSGITGFFTPRLIKKTLGLRAGKPTASDDTSKPFPRSNSTSSMSSGLPEQDR MAMTLPRNCQRSKLQLERTVSTSSQPEENVDRANDMLPKKSEESAAPSRERPKAKLLPRGATALPLRTPSGDLAITEKDPPGVGVAGVAA APKGKEKNGGARLGMAGVPEDGEQPGWPSPAKAAPVLPTTHNHKVPVLISPTLKHTPADVQLIGTDSQGNKFKLLSEHQVTSSGDKDRPR RVKPKCAPPPPPVMRLLQHPSICSDPTEEPTALTAGQSTSETQEGGKKAALGAVPISGKAGRPVMPPPQVPLPTSSISPAKMANGTAGTK VALRKTKQAAEKISADKISKEALLECADLLSSALTEPVPNSQLVDTGHQLLDYCSGYVDCIPQTRNKFAFREAVSKLELSLQELQVSSAA -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for ETV6-ABL2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ETV6-ABL2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for ETV6-ABL2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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