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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ETV6-ANO2 (FusionGDB2 ID:27702)

Fusion Gene Summary for ETV6-ANO2

check button Fusion gene summary
Fusion gene informationFusion gene name: ETV6-ANO2
Fusion gene ID: 27702
HgeneTgene
Gene symbol

ETV6

ANO2

Gene ID

2120

57101

Gene nameETS variant transcription factor 6anoctamin 2
SynonymsTEL|TEL/ABL|THC5C12orf3|TMEM16B
Cytomap

12p13.2

12p13.31

Type of geneprotein-codingprotein-coding
Descriptiontranscription factor ETV6ETS translocation variant 6ETS variant 6ETS-related protein Tel1TEL1 oncogeneets variant gene 6 (TEL oncogene)anoctamin-2anoctamin 2, calcium activated chloride channeltransmembrane protein 16B (eight membrane-spanning domains)
Modification date2020031320200329
UniProtAcc

P41212

Q9NQ90

Ensembl transtripts involved in fusion geneENST00000544715, ENST00000396373, 
ENST00000327087, ENST00000356134, 
ENST00000546188, ENST00000538154, 
Fusion gene scores* DoF score59 X 37 X 25=5457512 X 11 X 8=1056
# samples 5815
** MAII scorelog2(58/54575*10)=-6.55604351475058
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/1056*10)=-2.81557542886257
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ETV6 [Title/Abstract] AND ANO2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointETV6(11803094)-ANO2(5941769), # samples:1
Anticipated loss of major functional domain due to fusion event.ETV6-ANO2 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
ETV6-ANO2 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
ETV6-ANO2 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneETV6

GO:0000122

negative regulation of transcription by RNA polymerase II

10514502


check buttonFusion gene breakpoints across ETV6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ANO2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-HU-A4GY-01AETV6chr12

11803094

+ANO2chr12

5941769

-


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Fusion Gene ORF analysis for ETV6-ANO2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000544715ENST00000327087ETV6chr12

11803094

+ANO2chr12

5941769

-
3UTR-3CDSENST00000544715ENST00000356134ETV6chr12

11803094

+ANO2chr12

5941769

-
3UTR-3CDSENST00000544715ENST00000546188ETV6chr12

11803094

+ANO2chr12

5941769

-
3UTR-intronENST00000544715ENST00000538154ETV6chr12

11803094

+ANO2chr12

5941769

-
5CDS-intronENST00000396373ENST00000538154ETV6chr12

11803094

+ANO2chr12

5941769

-
Frame-shiftENST00000396373ENST00000546188ETV6chr12

11803094

+ANO2chr12

5941769

-
In-frameENST00000396373ENST00000327087ETV6chr12

11803094

+ANO2chr12

5941769

-
In-frameENST00000396373ENST00000356134ETV6chr12

11803094

+ANO2chr12

5941769

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000396373ETV6chr1211803094+ENST00000327087ANO2chr125941769-33313072742682802
ENST00000396373ETV6chr1211803094+ENST00000356134ANO2chr125941769-33283072742682802

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000396373ENST00000327087ETV6chr1211803094+ANO2chr125941769-0.0011740210.99882597
ENST00000396373ENST00000356134ETV6chr1211803094+ANO2chr125941769-0.0011804410.99881953

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Fusion Genomic Features for ETV6-ANO2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ETV6-ANO2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:11803094/chr12:5941769)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ETV6

P41212

ANO2

Q9NQ90

FUNCTION: Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. Plays a role in hematopoiesis and malignant transformation. {ECO:0000269|PubMed:25581430}.FUNCTION: Calcium-activated chloride channel (CaCC) which may play a role in olfactory signal transduction. Odorant molecules bind to odor-sensing receptors (OSRs), leading to an increase in calcium entry that activates CaCC current which amplifies the depolarization of the OSR cells, ANO2 seems to be the underlying chloride channel involved in this process. May mediate light perception amplification in retina. {ECO:0000269|PubMed:19474308, ECO:0000269|PubMed:20056604, ECO:0000269|PubMed:21890523, ECO:0000269|PubMed:21984732}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneANO2chr12:11803094chr12:5941769ENST000003270873261001_1003207999.0MotifNote=DLG4 binding (PDZ)
TgeneANO2chr12:11803094chr12:5941769ENST000003561344271001_10032081000.0MotifNote=DLG4 binding (PDZ)
TgeneANO2chr12:11803094chr12:5941769ENST00000327087326387_434207999.0Topological domainExtracellular
TgeneANO2chr12:11803094chr12:5941769ENST00000327087326456_538207999.0Topological domainCytoplasmic
TgeneANO2chr12:11803094chr12:5941769ENST00000327087326560_582207999.0Topological domainExtracellular
TgeneANO2chr12:11803094chr12:5941769ENST00000327087326604_623207999.0Topological domainCytoplasmic
TgeneANO2chr12:11803094chr12:5941769ENST00000327087326645_748207999.0Topological domainExtracellular
TgeneANO2chr12:11803094chr12:5941769ENST00000327087326770_801207999.0Topological domainCytoplasmic
TgeneANO2chr12:11803094chr12:5941769ENST00000327087326823_907207999.0Topological domainExtracellular
TgeneANO2chr12:11803094chr12:5941769ENST00000327087326929_1003207999.0Topological domainCytoplasmic
TgeneANO2chr12:11803094chr12:5941769ENST00000356134427387_4342081000.0Topological domainExtracellular
TgeneANO2chr12:11803094chr12:5941769ENST00000356134427456_5382081000.0Topological domainCytoplasmic
TgeneANO2chr12:11803094chr12:5941769ENST00000356134427560_5822081000.0Topological domainExtracellular
TgeneANO2chr12:11803094chr12:5941769ENST00000356134427604_6232081000.0Topological domainCytoplasmic
TgeneANO2chr12:11803094chr12:5941769ENST00000356134427645_7482081000.0Topological domainExtracellular
TgeneANO2chr12:11803094chr12:5941769ENST00000356134427770_8012081000.0Topological domainCytoplasmic
TgeneANO2chr12:11803094chr12:5941769ENST00000356134427823_9072081000.0Topological domainExtracellular
TgeneANO2chr12:11803094chr12:5941769ENST00000356134427929_10032081000.0Topological domainCytoplasmic
TgeneANO2chr12:11803094chr12:5941769ENST00000327087326366_386207999.0TransmembraneHelical
TgeneANO2chr12:11803094chr12:5941769ENST00000327087326435_455207999.0TransmembraneHelical
TgeneANO2chr12:11803094chr12:5941769ENST00000327087326539_559207999.0TransmembraneHelical
TgeneANO2chr12:11803094chr12:5941769ENST00000327087326583_603207999.0TransmembraneHelical
TgeneANO2chr12:11803094chr12:5941769ENST00000327087326624_644207999.0TransmembraneHelical
TgeneANO2chr12:11803094chr12:5941769ENST00000327087326749_769207999.0TransmembraneHelical
TgeneANO2chr12:11803094chr12:5941769ENST00000327087326802_822207999.0TransmembraneHelical
TgeneANO2chr12:11803094chr12:5941769ENST00000327087326908_928207999.0TransmembraneHelical
TgeneANO2chr12:11803094chr12:5941769ENST00000356134427366_3862081000.0TransmembraneHelical
TgeneANO2chr12:11803094chr12:5941769ENST00000356134427435_4552081000.0TransmembraneHelical
TgeneANO2chr12:11803094chr12:5941769ENST00000356134427539_5592081000.0TransmembraneHelical
TgeneANO2chr12:11803094chr12:5941769ENST00000356134427583_6032081000.0TransmembraneHelical
TgeneANO2chr12:11803094chr12:5941769ENST00000356134427624_6442081000.0TransmembraneHelical
TgeneANO2chr12:11803094chr12:5941769ENST00000356134427749_7692081000.0TransmembraneHelical
TgeneANO2chr12:11803094chr12:5941769ENST00000356134427802_8222081000.0TransmembraneHelical
TgeneANO2chr12:11803094chr12:5941769ENST00000356134427908_9282081000.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneETV6chr12:11803094chr12:5941769ENST00000396373+18339_42011453.0DNA bindingETS
HgeneETV6chr12:11803094chr12:5941769ENST00000396373+1840_12411453.0DomainPNT
TgeneANO2chr12:11803094chr12:5941769ENST000003270873261_365207999.0Topological domainCytoplasmic
TgeneANO2chr12:11803094chr12:5941769ENST000003561344271_3652081000.0Topological domainCytoplasmic


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Fusion Gene Sequence for ETV6-ANO2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>27702_27702_1_ETV6-ANO2_ETV6_chr12_11803094_ENST00000396373_ANO2_chr12_5941769_ENST00000327087_length(transcript)=3331nt_BP=307nt
GCGTCCCGGGTCCCCGCGCCGCGCCGCGACCTGCAGACCCCGCCGCCGCGCTCGGGCCCGTCTCCCACGCCCCCGCCGCCCCGCGCGCCC
AACTCCGCCGGCCGCCCCGCCCCGCCCCGCGCGCTCCAGACCCCCGGGGCGGCTGCCGGGAGAGATGCTGGAAGAAACTTCTTAAATGAC
CGCGTCTGGCTGGCCGTGGAGCCTTTCTGGGTTGGGGAGAGGAAAGGAAAGTGGAAAAAACCTGAGAACTTCCTGATCTCTCTCGCTGTG
AGACATGTCTGAGACTCCTGCTCAGTGTAGCATTAAGATGTACGAGATCAAAGCAGGAGGCAGCATTGCAAAGAAGTTCAGCGCGGCTCT
GCAGAAGCTGAGCTCGCACCTGCAGCCCCGAGTTCCAGAACACAGCAACAACAAGATGAAAAACCTCTCCTACCCATTCTCCAGGGAGAA
GATGTACCTGTACAACATCCAGGAAAAGGACACCTTCTTTGATAATGCCACCCGCAGCCGCATTGTGCACGAGATCCTGAAGCGCACAGC
CTGCTCCCGAGCCAACAACACGATGGGTATTAACTCTCTGATCGCAAACAATATCTATGAGGCTGCCTACCCTCTTCATGACGGTGAATA
CGATAGTCCAGAGGACGATATGAATGACAGGAAGCTGCTATATCAAGAATGGGCGCGCTATGGAGTGTTCTATAAGTTCCAACCTATTGA
CCTCATCAGAAAGTATTTTGGAGAAAAAATTGGACTGTATTTTGCCTGGCTGGGATTATATACATCATTCCTCATCCCATCTTCTGTAAT
TGGAGTGATTGTGTTTCTTTATGGATGTGCAACAATTGAAGAAGATATTCCCAGCAGAGAGATGTGTGACCAGCAGAATGCCTTCACCAT
GTGTCCCCTGTGTGACAAGTCCTGTGATTACTGGAACCTCAGCTCAGCCTGTGGGACCGCGCAGGCCAGCCACCTGTTTGACAACCCTGC
CACCGTCTTCTTCTCTATCTTCATGGCTCTGTGGGCTACCATGTTCCTGGAAAACTGGAAGAGGCTACAGATGCGACTGGGCTACTTTTG
GGACCTGACTGGCATAGAAGAGGAAGAAGAACGTGCCCAGGAACATTCCAGGCCTGAGTATGAAACCAAAGTTCGAGAGAAAATGCTAAA
GGAGAGCAACCAGTCTGCTGTCCAGAAATTGGAAACAAACACGACGGAGTGTGGCGATGAGGATGATGAAGATAAACTGACCTGGAAGGA
TCGTTTCCCAGGTTACCTGATGAACTTTGCCTCCATCTTATTCATGATTGCCCTGACATTCTCAATCGTCTTTGGGGTGATAGTGTATCG
AATAACAACTGCAGCCGCTCTGTCTCTCAATAAGGCTACACGCTCCAATGTCCGGGTGACAGTGACAGCAACAGCAGTCATCATCAACCT
CGTGGTCATCCTCATCCTGGACGAGATCTACGGCGCTGTGGCCAAGTGGCTCACCAAAATTGAGGTTCCGAAAACAGAACAGACTTTTGA
AGAGCGCCTGATCCTCAAAGCTTTCTTGCTCAAGTTTGTCAATGCCTACTCCCCCATCTTCTATGTGGCCTTTTTCAAAGGGAGGTTTGT
GGGCAGGCCTGGAAGCTACGTCTATGTATTCGATGGTTACCGCATGGAAGAGTGTGCTCCAGGGGGCTGTCTCATGGAGCTCTGCATTCA
GCTCAGCATCATCATGTTGGGGAAGCAGTTGATCCAGAACAACATCTTTGAGATTGGAGTCCCGAAGCTAAAGAAACTATTTCGAAAGCT
GAAAGATGAGACCGAAGCTGGAGAAACTGACTCTGCCCATTCGAAACATCCAGAGCAGTGGGACCTAGACTACAGCTTGGAACCATACAC
AGGACTGACTCCGGAGTACATGGAAATGATCATCCAGTTTGGTTTTGTCACCCTCTTCGTGGCCTCCTTTCCCCTGGCACCTGTGTTTGC
CCTCCTCAACAACGTCATTGAAGTGCGGCTCGATGCAAAGAAGTTTGTTACAGAGCTGAGACGGCCGGATGCTGTAAGAACCAAAGATAT
CGGAATCTGGTTTGACATTCTCTCTGGAATTGGCAAGTTCTCTGTTATCAGCAACGCTTTTGTCATTGCGATCACCTCCGACTTTATCCC
CCGCCTGGTGTACCAGTACTCCTACAGTCACAATGGGACTCTGCACGGCTTTGTCAACCACACCCTCTCCTTTTTCAACGTCAGCCAGCT
GAAGGAGGGGACGCAGCCAGAAAACTCACAGTTTGACCAGGAGGTTCAGTTCTGCAGGTTTAAGGATTACCGAGAGCCGCCATGGGCCCC
GAACCCTTATGAGTTTTCGAAACAGTACTGGTTTATTCTGTCCGCCCGTCTGGCTTTTGTCATAATCTTCCAGAACCTCGTGATGTTCCT
GAGCGTCCTCGTGGACTGGATGATTCCAGACATCCCCACGGACATCAGCGACCAGATCAAGAAAGAGAAGAGCTTATTAGTGGATTTCTT
CCTGAAAGAGGAGCATGAGAAGCTCAAGCTGATGGATGAGCCGGCTCTGAGGAGCCCAGGAGGTGGGGATCGAAGCAGGAGCCGGGCAGC
CAGCTCAGCACCTTCAGGCCAAAGCCAGCTGGGCAGCATGATGTCGTCAGGCTCTCAGCACACCAATGTGTGAGCAGTTCAGCCTGCAGC
AGAGGAGGGCACGGCAGCAGAGACACGCACATGCACGTAAGCATGTTCCTACACCCACATGGCGTGCTGTCTGTCTGCAGGGGCCTGGCT
TGATGGGGTCTTGAAGAGGGGGCAGTGTGTAAAAAGAAAGAGCCTGACAGAATGAGTGTAGGAAGGAAGAGAAATGATGCTACATCTCAG
AAACTTCAAGCTTAAGTTTCTTTTAGGTCCCCTTTTAAGCTGCATCCTTTTGAGGGATTGGAACCCCACTGGGGTCTCTCCACCCCAGAG
TCTCAGGCACCGCGAGCATTCCCATGTACCCTGGGGCACCCTCTTGTACTTCACCATCATTTCTGACTTTGACCAGCTGTAAGAGAAATG
CAGTCAGGAGCACAGCATCCCCTACTTACTATCACTACAAGAAAACTGAGTCACTTGCAGTGGGGCTGCCACAGTCTCAGCAGATGCAAA
TTAAGTTACAAGGCTGAATGGTGCAGCCGCTGGACCTGATAGTAAGGTGCAAAGGTCCAAACCTGGGCTTGTCTCCACTTCACGTCACAA
AAACGTTTGGAGCTAAATGCAGATAACCATCATTTTATGAAAGTTCAGATTTAAAATAATAAAATAAATGGACACATTCTTTATAAAGAT

>27702_27702_1_ETV6-ANO2_ETV6_chr12_11803094_ENST00000396373_ANO2_chr12_5941769_ENST00000327087_length(amino acids)=802AA_BP=11
MSETPAQCSIKMYEIKAGGSIAKKFSAALQKLSSHLQPRVPEHSNNKMKNLSYPFSREKMYLYNIQEKDTFFDNATRSRIVHEILKRTAC
SRANNTMGINSLIANNIYEAAYPLHDGEYDSPEDDMNDRKLLYQEWARYGVFYKFQPIDLIRKYFGEKIGLYFAWLGLYTSFLIPSSVIG
VIVFLYGCATIEEDIPSREMCDQQNAFTMCPLCDKSCDYWNLSSACGTAQASHLFDNPATVFFSIFMALWATMFLENWKRLQMRLGYFWD
LTGIEEEEERAQEHSRPEYETKVREKMLKESNQSAVQKLETNTTECGDEDDEDKLTWKDRFPGYLMNFASILFMIALTFSIVFGVIVYRI
TTAAALSLNKATRSNVRVTVTATAVIINLVVILILDEIYGAVAKWLTKIEVPKTEQTFEERLILKAFLLKFVNAYSPIFYVAFFKGRFVG
RPGSYVYVFDGYRMEECAPGGCLMELCIQLSIIMLGKQLIQNNIFEIGVPKLKKLFRKLKDETEAGETDSAHSKHPEQWDLDYSLEPYTG
LTPEYMEMIIQFGFVTLFVASFPLAPVFALLNNVIEVRLDAKKFVTELRRPDAVRTKDIGIWFDILSGIGKFSVISNAFVIAITSDFIPR
LVYQYSYSHNGTLHGFVNHTLSFFNVSQLKEGTQPENSQFDQEVQFCRFKDYREPPWAPNPYEFSKQYWFILSARLAFVIIFQNLVMFLS

--------------------------------------------------------------
>27702_27702_2_ETV6-ANO2_ETV6_chr12_11803094_ENST00000396373_ANO2_chr12_5941769_ENST00000356134_length(transcript)=3328nt_BP=307nt
GCGTCCCGGGTCCCCGCGCCGCGCCGCGACCTGCAGACCCCGCCGCCGCGCTCGGGCCCGTCTCCCACGCCCCCGCCGCCCCGCGCGCCC
AACTCCGCCGGCCGCCCCGCCCCGCCCCGCGCGCTCCAGACCCCCGGGGCGGCTGCCGGGAGAGATGCTGGAAGAAACTTCTTAAATGAC
CGCGTCTGGCTGGCCGTGGAGCCTTTCTGGGTTGGGGAGAGGAAAGGAAAGTGGAAAAAACCTGAGAACTTCCTGATCTCTCTCGCTGTG
AGACATGTCTGAGACTCCTGCTCAGTGTAGCATTAAGATGTACGAGATCAAAGCAGGAGGCAGCATTGCAAAGAAGTTCAGCGCGGCTCT
GCAGAAGCTGAGCTCGCACCTGCAGCCCCGAGTTCCAGAACACAGCAACAACAAGATGAAAAACCTCTCCTACCCATTCTCCAGGGAGAA
GATGTACCTGTACAACATCCAGGAAAAGGACACCTTCTTTGATAATGCCACCCGCAGCCGCATTGTGCACGAGATCCTGAAGCGCACAGC
CTGCTCCCGAGCCAACAACACGATGGGTATTAACTCTCTGATCGCAAACAATATCTATGAGGCTGCCTACCCTCTTCATGACGGTGAATA
CGATAGTCCAGAGGACGATATGAATGACAGGAAGCTGCTATATCAAGAATGGGCGCGCTATGGAGTGTTCTATAAGTTCCAACCTATTGA
CCTCATCAGAAAGTATTTTGGAGAAAAAATTGGACTGTATTTTGCCTGGCTGGGATTATATACATCATTCCTCATCCCATCTTCTGTAAT
TGGAGTGATTGTGTTTCTTTATGGATGTGCAACAATTGAAGAAGATATTCCCAGCAGAGAGATGTGTGACCAGCAGAATGCCTTCACCAT
GTGTCCCCTGTGTGACAAGTCCTGTGATTACTGGAACCTCAGCTCAGCCTGTGGGACCGCGCAGGCCAGCCACCTGTTTGACAACCCTGC
CACCGTCTTCTTCTCTATCTTCATGGCTCTGTGGGCTACCATGTTCCTGGAAAACTGGAAGAGGCTACAGATGCGACTGGGCTACTTTTG
GGACCTGACTGGCATAGAAGAGGAAGAAGAACGTGCCCAGGAACATTCCAGGCCTGAGTATGAAACCAAAGTTCGAGAGAAAATGCTAAA
GGAGAGCAACCAGTCTGCTGTCCAGAAATTGGAAACAAACACGACGGAGTGTGGCGATGAGGATGATGAAGATAAACTGACCTGGAAGGA
TCGTTTCCCAGGTTACCTGATGAACTTTGCCTCCATCTTATTCATGATTGCCCTGACATTCTCAATCGTCTTTGGGGTGATAGTGTATCG
AATAACAACTGCAGCCGCTCTGTCTCTCAATAAGGCTACACGCTCCAATGTCCGGGTGACAGTGACAGCAACAGCAGTCATCATCAACCT
CGTGGTCATCCTCATCCTGGACGAGATCTACGGCGCTGTGGCCAAGTGGCTCACCAAAATTGAGGTTCCGAAAACAGAACAGACTTTTGA
AGAGCGCCTGATCCTCAAAGCTTTCTTGCTCAAGTTTGTCAATGCCTACTCCCCCATCTTCTATGTGGCCTTTTTCAAAGGGAGGTTTGT
GGGCAGGCCTGGAAGCTACGTCTATGTATTCGATGGTTACCGCATGGAAGAGTGTGCTCCAGGGGGCTGTCTCATGGAGCTCTGCATTCA
GCTCAGCATCATCATGTTGGGGAAGCAGTTGATCCAGAACAACATCTTTGAGATTGGAGTCCCGAAGCTAAAGAAACTATTTCGAAAGCT
GAAAGATGAGACCGAAGCTGGAGAAACTGACTCTGCCCATTCGAAACATCCAGAGCAGTGGGACCTAGACTACAGCTTGGAACCATACAC
AGGACTGACTCCGGAGTACATGGAAATGATCATCCAGTTTGGTTTTGTCACCCTCTTCGTGGCCTCCTTTCCCCTGGCACCTGTGTTTGC
CCTCCTCAACAACGTCATTGAAGTGCGGCTCGATGCAAAGAAGTTTGTTACAGAGCTGAGACGGCCGGATGCTGTAAGAACCAAAGATAT
CGGAATCTGGTTTGACATTCTCTCTGGAATTGGCAAGTTCTCTGTTATCAGCAACGCTTTTGTCATTGCGATCACCTCCGACTTTATCCC
CCGCCTGGTGTACCAGTACTCCTACAGTCACAATGGGACTCTGCACGGCTTTGTCAACCACACCCTCTCCTTTTTCAACGTCAGCCAGCT
GAAGGAGGGGACGCAGCCAGAAAACTCACAGTTTGACCAGGAGGTTCAGTTCTGCAGGTTTAAGGATTACCGAGAGCCGCCATGGGCCCC
GAACCCTTATGAGTTTTCGAAACAGTACTGGTTTATTCTGTCCGCCCGTCTGGCTTTTGTCATAATCTTCCAGAACCTCGTGATGTTCCT
GAGCGTCCTCGTGGACTGGATGATTCCAGACATCCCCACGGACATCAGCGACCAGATCAAGAAAGAGAAGAGCTTATTAGTGGATTTCTT
CCTGAAAGAGGAGCATGAGAAGCTCAAGCTGATGGATGAGCCGGCTCTGAGGAGCCCAGGAGGTGGGGATCGAAGCAGGAGCCGGGCAGC
CAGCTCAGCACCTTCAGGCCAAAGCCAGCTGGGCAGCATGATGTCGTCAGGCTCTCAGCACACCAATGTGTGAGCAGTTCAGCCTGCAGC
AGAGGAGGGCACGGCAGCAGAGACACGCACATGCACGTAAGCATGTTCCTACACCCACATGGCGTGCTGTCTGTCTGCAGGGGCCTGGCT
TGATGGGGTCTTGAAGAGGGGGCAGTGTGTAAAAAGAAAGAGCCTGACAGAATGAGTGTAGGAAGGAAGAGAAATGATGCTACATCTCAG
AAACTTCAAGCTTAAGTTTCTTTTAGGTCCCCTTTTAAGCTGCATCCTTTTGAGGGATTGGAACCCCACTGGGGTCTCTCCACCCCAGAG
TCTCAGGCACCGCGAGCATTCCCATGTACCCTGGGGCACCCTCTTGTACTTCACCATCATTTCTGACTTTGACCAGCTGTAAGAGAAATG
CAGTCAGGAGCACAGCATCCCCTACTTACTATCACTACAAGAAAACTGAGTCACTTGCAGTGGGGCTGCCACAGTCTCAGCAGATGCAAA
TTAAGTTACAAGGCTGAATGGTGCAGCCGCTGGACCTGATAGTAAGGTGCAAAGGTCCAAACCTGGGCTTGTCTCCACTTCACGTCACAA

>27702_27702_2_ETV6-ANO2_ETV6_chr12_11803094_ENST00000396373_ANO2_chr12_5941769_ENST00000356134_length(amino acids)=802AA_BP=11
MSETPAQCSIKMYEIKAGGSIAKKFSAALQKLSSHLQPRVPEHSNNKMKNLSYPFSREKMYLYNIQEKDTFFDNATRSRIVHEILKRTAC
SRANNTMGINSLIANNIYEAAYPLHDGEYDSPEDDMNDRKLLYQEWARYGVFYKFQPIDLIRKYFGEKIGLYFAWLGLYTSFLIPSSVIG
VIVFLYGCATIEEDIPSREMCDQQNAFTMCPLCDKSCDYWNLSSACGTAQASHLFDNPATVFFSIFMALWATMFLENWKRLQMRLGYFWD
LTGIEEEEERAQEHSRPEYETKVREKMLKESNQSAVQKLETNTTECGDEDDEDKLTWKDRFPGYLMNFASILFMIALTFSIVFGVIVYRI
TTAAALSLNKATRSNVRVTVTATAVIINLVVILILDEIYGAVAKWLTKIEVPKTEQTFEERLILKAFLLKFVNAYSPIFYVAFFKGRFVG
RPGSYVYVFDGYRMEECAPGGCLMELCIQLSIIMLGKQLIQNNIFEIGVPKLKKLFRKLKDETEAGETDSAHSKHPEQWDLDYSLEPYTG
LTPEYMEMIIQFGFVTLFVASFPLAPVFALLNNVIEVRLDAKKFVTELRRPDAVRTKDIGIWFDILSGIGKFSVISNAFVIAITSDFIPR
LVYQYSYSHNGTLHGFVNHTLSFFNVSQLKEGTQPENSQFDQEVQFCRFKDYREPPWAPNPYEFSKQYWFILSARLAFVIIFQNLVMFLS

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Fusion Gene PPI Analysis for ETV6-ANO2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ETV6-ANO2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ETV6-ANO2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource