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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ETV6-JAK2 (FusionGDB2 ID:27724)

Fusion Gene Summary for ETV6-JAK2

Fusion gene summary

Fusion gene information	Fusion gene name: ETV6-JAK2
	Fusion gene ID: 27724
		Hgene	Tgene
	Gene symbol	ETV6	JAK2
	Gene ID	2120	3717
	Gene name	ETS variant transcription factor 6	Janus kinase 2
	Synonyms	TEL\|TEL/ABL\|THC5	JTK10\|THCYT3
	Cytomap	12p13.2	9p24.1
	Type of gene	protein-coding	protein-coding
	Description	transcription factor ETV6ETS translocation variant 6ETS variant 6ETS-related protein Tel1TEL1 oncogeneets variant gene 6 (TEL oncogene)	tyrosine-protein kinase JAK2JAK-2Janus kinase 2 (a protein tyrosine kinase)
	Modification date	20200313	20200329
	UniProtAcc	P41212	O60674
	Ensembl transtripts involved in fusion gene	ENST00000396373, ENST00000544715,	ENST00000487310, ENST00000381652, ENST00000539801, ENST00000544510,
Fusion gene scores	* DoF score	59 X 37 X 25=54575	22 X 26 X 9=5148
	# samples	58	15
	** MAII score	log2(58/54575*10)=-6.55604351475058 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(15/5148*10)=-5.10097764772482 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ETV6 [Title/Abstract] AND JAK2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint
Anticipated loss of major functional domain due to fusion event.	ETV6-JAK2 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. ETV6-JAK2 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF. ETV6-JAK2 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF. ETV6-JAK2 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. ETV6-JAK2 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF. ETV6-JAK2 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. ETV6-JAK2 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ETV6	GO:0000122	negative regulation of transcription by RNA polymerase II	10514502
Tgene	JAK2	GO:0010811	positive regulation of cell-substrate adhesion	10925297
Tgene	JAK2	GO:0019221	cytokine-mediated signaling pathway	8609418
Tgene	JAK2	GO:0033209	tumor necrosis factor-mediated signaling pathway	8609418
Tgene	JAK2	GO:0034612	response to tumor necrosis factor	8609418
Tgene	JAK2	GO:0035409	histone H3-Y41 phosphorylation	19783980
Tgene	JAK2	GO:0035722	interleukin-12-mediated signaling pathway	7528775
Tgene	JAK2	GO:0046677	response to antibiotic	16280321
Tgene	JAK2	GO:0050727	regulation of inflammatory response	10925297
Tgene	JAK2	GO:0060396	growth hormone receptor signaling pathway	10925297
Tgene	JAK2	GO:0070671	response to interleukin-12	7528775

Fusion gene breakpoints across ETV6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across JAK2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerKB3	.	.	ETV6	chr12	12006495	+	JAK2	chr9	5078305	+
ChimerKB3	.	.	ETV6	chr12	12006495	+	JAK2	chr9	5080228	+
ChimerKB3	.	.	ETV6	chr12	12022903	+	JAK2	chr9	5069021	+
ChimerKB3	.	.	ETV6	chr12	12022903	+	JAK2	chr9	5069924	+
ChimerKB3	.	.	ETV6	chr12	12022903	+	JAK2	chr9	5081724	+

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Fusion Gene ORF analysis for ETV6-JAK2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000396373	ENST00000487310	ETV6	chr12	12006495	+	JAK2	chr9	5078305	+
5CDS-intron	ENST00000396373	ENST00000487310	ETV6	chr12	12006495	+	JAK2	chr9	5080228	+
5CDS-intron	ENST00000396373	ENST00000487310	ETV6	chr12	12022903	+	JAK2	chr9	5069021	+
5CDS-intron	ENST00000396373	ENST00000487310	ETV6	chr12	12022903	+	JAK2	chr9	5069924	+
5CDS-intron	ENST00000396373	ENST00000487310	ETV6	chr12	12022903	+	JAK2	chr9	5081724	+
Frame-shift	ENST00000396373	ENST00000381652	ETV6	chr12	12006495	+	JAK2	chr9	5078305	+
Frame-shift	ENST00000396373	ENST00000381652	ETV6	chr12	12022903	+	JAK2	chr9	5069021	+
Frame-shift	ENST00000396373	ENST00000539801	ETV6	chr12	12006495	+	JAK2	chr9	5078305	+
Frame-shift	ENST00000396373	ENST00000539801	ETV6	chr12	12022903	+	JAK2	chr9	5069021	+
Frame-shift	ENST00000396373	ENST00000544510	ETV6	chr12	12006495	+	JAK2	chr9	5078305	+
Frame-shift	ENST00000396373	ENST00000544510	ETV6	chr12	12022903	+	JAK2	chr9	5069021	+
In-frame	ENST00000396373	ENST00000381652	ETV6	chr12	12006495	+	JAK2	chr9	5080228	+
In-frame	ENST00000396373	ENST00000381652	ETV6	chr12	12022903	+	JAK2	chr9	5069924	+
In-frame	ENST00000396373	ENST00000381652	ETV6	chr12	12022903	+	JAK2	chr9	5081724	+
In-frame	ENST00000396373	ENST00000539801	ETV6	chr12	12006495	+	JAK2	chr9	5080228	+
In-frame	ENST00000396373	ENST00000539801	ETV6	chr12	12022903	+	JAK2	chr9	5069924	+
In-frame	ENST00000396373	ENST00000539801	ETV6	chr12	12022903	+	JAK2	chr9	5081724	+
In-frame	ENST00000396373	ENST00000544510	ETV6	chr12	12006495	+	JAK2	chr9	5080228	+
In-frame	ENST00000396373	ENST00000544510	ETV6	chr12	12022903	+	JAK2	chr9	5069924	+
In-frame	ENST00000396373	ENST00000544510	ETV6	chr12	12022903	+	JAK2	chr9	5081724	+
intron-3CDS	ENST00000544715	ENST00000381652	ETV6	chr12	12006495	+	JAK2	chr9	5078305	+
intron-3CDS	ENST00000544715	ENST00000381652	ETV6	chr12	12006495	+	JAK2	chr9	5080228	+
intron-3CDS	ENST00000544715	ENST00000381652	ETV6	chr12	12022903	+	JAK2	chr9	5069021	+
intron-3CDS	ENST00000544715	ENST00000381652	ETV6	chr12	12022903	+	JAK2	chr9	5069924	+
intron-3CDS	ENST00000544715	ENST00000381652	ETV6	chr12	12022903	+	JAK2	chr9	5081724	+
intron-3CDS	ENST00000544715	ENST00000539801	ETV6	chr12	12006495	+	JAK2	chr9	5078305	+
intron-3CDS	ENST00000544715	ENST00000539801	ETV6	chr12	12006495	+	JAK2	chr9	5080228	+
intron-3CDS	ENST00000544715	ENST00000539801	ETV6	chr12	12022903	+	JAK2	chr9	5069021	+
intron-3CDS	ENST00000544715	ENST00000539801	ETV6	chr12	12022903	+	JAK2	chr9	5069924	+
intron-3CDS	ENST00000544715	ENST00000539801	ETV6	chr12	12022903	+	JAK2	chr9	5081724	+
intron-3CDS	ENST00000544715	ENST00000544510	ETV6	chr12	12006495	+	JAK2	chr9	5078305	+
intron-3CDS	ENST00000544715	ENST00000544510	ETV6	chr12	12006495	+	JAK2	chr9	5080228	+
intron-3CDS	ENST00000544715	ENST00000544510	ETV6	chr12	12022903	+	JAK2	chr9	5069021	+
intron-3CDS	ENST00000544715	ENST00000544510	ETV6	chr12	12022903	+	JAK2	chr9	5069924	+
intron-3CDS	ENST00000544715	ENST00000544510	ETV6	chr12	12022903	+	JAK2	chr9	5081724	+
intron-intron	ENST00000544715	ENST00000487310	ETV6	chr12	12006495	+	JAK2	chr9	5078305	+
intron-intron	ENST00000544715	ENST00000487310	ETV6	chr12	12006495	+	JAK2	chr9	5080228	+
intron-intron	ENST00000544715	ENST00000487310	ETV6	chr12	12022903	+	JAK2	chr9	5069021	+
intron-intron	ENST00000544715	ENST00000487310	ETV6	chr12	12022903	+	JAK2	chr9	5069924	+
intron-intron	ENST00000544715	ENST00000487310	ETV6	chr12	12022903	+	JAK2	chr9	5081724	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000396373	ETV6	chr12	12006495	+	ENST00000539801	JAK2	chr9	5080228	+	2028	737	274	2004	576
ENST00000396373	ETV6	chr12	12006495	+	ENST00000381652	JAK2	chr9	5080228	+	3397	737	274	2004	576
ENST00000396373	ETV6	chr12	12006495	+	ENST00000544510	JAK2	chr9	5080228	+	2063	737	274	2004	576
ENST00000396373	ETV6	chr12	12022903	+	ENST00000539801	JAK2	chr9	5069924	+	3192	1283	274	3168	964
ENST00000396373	ETV6	chr12	12022903	+	ENST00000381652	JAK2	chr9	5069924	+	4561	1283	274	3168	964
ENST00000396373	ETV6	chr12	12022903	+	ENST00000544510	JAK2	chr9	5069924	+	3227	1283	274	3168	964
ENST00000396373	ETV6	chr12	12022903	+	ENST00000539801	JAK2	chr9	5081724	+	2271	1283	274	2247	657
ENST00000396373	ETV6	chr12	12022903	+	ENST00000381652	JAK2	chr9	5081724	+	3640	1283	274	2247	657
ENST00000396373	ETV6	chr12	12022903	+	ENST00000544510	JAK2	chr9	5081724	+	2306	1283	274	2247	657

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for ETV6-JAK2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ETV6-JAK2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:/chr9:)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ETV6 P41212	JAK2 O60674
FUNCTION: Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. Plays a role in hematopoiesis and malignant transformation. {ECO:0000269\|PubMed:25581430}.	FUNCTION: Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins (PubMed:7615558). Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins (PubMed:9618263). Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain. Then, STAT5 (STAT5A or STAT5B) is recruited, phosphorylated and activated by JAK2. Once activated, dimerized STAT5 translocates into the nucleus and promotes the transcription of several essential genes involved in the modulation of erythropoiesis. Part of a signaling cascade that is activated by increased cellular retinol and that leads to the activation of STAT5 (STAT5A or STAT5B) (PubMed:21368206). In addition, JAK2 mediates angiotensin-2-induced ARHGEF1 phosphorylation (PubMed:20098430). Plays a role in cell cycle by phosphorylating CDKN1B (PubMed:21423214). Cooperates with TEC through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. In the nucleus, plays a key role in chromatin by specifically mediating phosphorylation of 'Tyr-41' of histone H3 (H3Y41ph), a specific tag that promotes exclusion of CBX5 (HP1 alpha) from chromatin (PubMed:19783980). {ECO:0000269\|PubMed:12023369, ECO:0000269\|PubMed:19783980, ECO:0000269\|PubMed:20098430, ECO:0000269\|PubMed:21368206, ECO:0000269\|PubMed:21423214, ECO:0000269\|PubMed:7615558, ECO:0000269\|PubMed:9618263}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for ETV6-JAK2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>27724_27724_1_ETV6-JAK2_ETV6_chr12_12006495_ENST00000396373_JAK2_chr9_5080228_ENST00000381652_length(transcript)=3397nt_BP=737nt
GCGTCCCGGGTCCCCGCGCCGCGCCGCGACCTGCAGACCCCGCCGCCGCGCTCGGGCCCGTCTCCCACGCCCCCGCCGCCCCGCGCGCCC
AACTCCGCCGGCCGCCCCGCCCCGCCCCGCGCGCTCCAGACCCCCGGGGCGGCTGCCGGGAGAGATGCTGGAAGAAACTTCTTAAATGAC
CGCGTCTGGCTGGCCGTGGAGCCTTTCTGGGTTGGGGAGAGGAAAGGAAAGTGGAAAAAACCTGAGAACTTCCTGATCTCTCTCGCTGTG
AGACATGTCTGAGACTCCTGCTCAGTGTAGCATTAAGCAGGAACGAATTTCATATACACCTCCAGAGAGCCCAGTGCCGAGTTACGCTTC
CTCGACGCCACTTCATGTTCCAGTGCCTCGAGCGCTCAGGATGGAGGAAGACTCGATCCGCCTGCCTGCGCACCTGCGCTTGCAGCCAAT
TTACTGGAGCAGGGATGACGTAGCCCAGTGGCTCAAGTGGGCTGAAAATGAGTTTTCTTTAAGGCCAATTGACAGCAACACGTTTGAAAT
GAATGGCAAAGCTCTCCTGCTGCTGACCAAAGAGGACTTTCGCTATCGATCTCCTCATTCAGGTGATGTGCTCTATGAACTCCTTCAGCA
TATTCTGAAGCAGAGGAAACCTCGGATTCTTTTTTCACCATTCTTCCACCCTGGAAACTCTATACACACACAGCCGGAGGTCATACTGCA
TCAGAACCATGAAGAAGTTCTTCAGGAGAGAATACCATGGGTACCACCTGAATGCATTGAAAATCCTAAAAATTTAAATTTGGCAACAGA
CAAATGGAGTTTTGGTACCACTTTGTGGGAAATCTGCAGTGGAGGAGATAAACCTCTAAGTGCTCTGGATTCTCAAAGAAAGCTACAATT
TTATGAAGATAGGCATCAGCTTCCTGCACCAAAGTGGGCAGAATTAGCAAACCTTATAAATAATTGTATGGATTATGAACCAGATTTCAG
GCCTTCTTTCAGAGCCATCATACGAGATCTTAACAGTTTGTTTACTCCAGATTATGAACTATTAACAGAAAATGACATGTTACCAAATAT
GAGGATAGGTGCCCTGGGGTTTTCTGGTGCCTTTGAAGACCGGGATCCTACACAGTTTGAAGAGAGACATTTGAAATTTCTACAGCAACT
TGGCAAGGGTAATTTTGGGAGTGTGGAGATGTGCCGGTATGACCCTCTACAGGACAACACTGGGGAGGTGGTCGCTGTAAAAAAGCTTCA
GCATAGTACTGAAGAGCACCTAAGAGACTTTGAAAGGGAAATTGAAATCCTGAAATCCCTACAGCATGACAACATTGTAAAGTACAAGGG
AGTGTGCTACAGTGCTGGTCGGCGTAATCTAAAATTAATTATGGAATATTTACCATATGGAAGTTTACGAGACTATCTTCAAAAACATAA
AGAACGGATAGATCACATAAAACTTCTGCAGTACACATCTCAGATATGCAAGGGTATGGAGTATCTTGGTACAAAAAGGTATATCCACAG
GGATCTGGCAACGAGAAATATATTGGTGGAGAACGAGAACAGAGTTAAAATTGGAGATTTTGGGTTAACCAAAGTCTTGCCACAAGACAA
AGAATACTATAAAGTAAAAGAACCTGGTGAAAGTCCCATATTCTGGTATGCTCCAGAATCACTGACAGAGAGCAAGTTTTCTGTGGCCTC
AGATGTTTGGAGCTTTGGAGTGGTTCTGTATGAACTTTTCACATACATTGAGAAGAGTAAAAGTCCACCAGCGGAATTTATGCGTATGAT
TGGCAATGACAAACAAGGACAGATGATCGTGTTCCATTTGATAGAACTTTTGAAGAATAATGGAAGATTACCAAGACCAGATGGATGCCC
AGATGAGATCTATATGATCATGACAGAATGCTGGAACAATAATGTAAATCAACGCCCCTCCTTTAGGGATCTAGCTCTTCGAGTGGATCA
AATAAGGGATAACATGGCTGGATGAAAGAAATGACCTTCATTCTGAGACCAAAGTAGATTTACAGAACAAAGTTTTATATTTCACATTGC
TGTGGACTATTATTACATATATCATTATTATATAAATCATGATGCTAGCCAGCAAAGATGTGAAAATATCTGCTCAAAACTTTCAAAGTT
TAGTAAGTTTTTCTTCATGAGGCCACCAGTAAAAGACATTAATGAGAATTCCTTAGCAAGGATTTTGTAAGAAGTTTCTTAAACATTGTC
AGTTAACATCACTCTTGTCTGGCAAAAGAAAAAAAATAGACTTTTTCAACTCAGCTTTTTGAGACCTGAAAAAATTATTATGTAAATTTT
GCAATGTTAAAGATGCACAGAATATGTATGTATAGTTTTTACCACAGTGGATGTATAATACCTTGGCATCTTGTGTGATGTTTTACACAC
ATGAGGGCTGGTGTTCATTAATACTGTTTTCTAATTTTTCCATAGTTAATCTATAATTAATTACTTCACTATACAAACAAATTAAGATGT
TCAGATAATTGAATAAGTACCTTTGTGTCCTTGTTCATTTATATCGCTGGCCAGCATTATAAGCAGGTGTATACTTTTAGCTTGTAGTTC
CATGTACTGTAAATATTTTTCACATAAAGGGAACAAATGTCTAGTTTTATTTGTATAGGAAATTTCCCTGACCCTAAATAATACATTTTG
AAATGAAACAAGCTTACAAAGATATAATCTATTTTATTATGGTTTCCCTTGTATCTATTTGTGGTGAATGTGTTTTTTAAATGGAACTAT
CTCCAAATTTTTCTAAGACTACTATGAACAGTTTTCTTTTAAAATTTTGAGATTAAGAATGCCAGGAATATTGTCATCCTTTGAGCTGCT
GACTGCCAATAACATTCTTCGATCTCTGGGATTTATGCTCATGAACTAAATTTAAGCTTAAGCCATAAAATAGATTAGATTGTTTTTTAA
AAATGGATAGCTCATTAAGAAGTGCAGCAGGTTAAGAATTTTTTCCTAAAGACTGTATATTTGAGGGGTTTCAGAATTTTGCATTGCAGT
CATAGAAGAGATTTATTTCCTTTTTAGAGGGGAAATGAGGTAAATAAGTAAAAAAGTATGCTTGTTAATTTTATTCAAGAATGCCAGTAG
AAAATTCATAACGTGTATCTTTAAGAAAAATGAGCATACATCTTAAATCTTTTCAATTAAGTATAAGGGGTTGTTCGTTGTTGTCATTTG
TTATAGTGCTACTCCACTTTAGACACCATAGCTAAAATAAAATATGGTGGGTTTTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG

>27724_27724_1_ETV6-JAK2_ETV6_chr12_12006495_ENST00000396373_JAK2_chr9_5080228_ENST00000381652_length(amino acids)=576AA_BP=154
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN
GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEVLQERIPWVPPECIENPKNLNLATDK
WSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMR
IGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGV
CYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKE
YYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPD

--------------------------------------------------------------
>27724_27724_2_ETV6-JAK2_ETV6_chr12_12006495_ENST00000396373_JAK2_chr9_5080228_ENST00000539801_length(transcript)=2028nt_BP=737nt
GCGTCCCGGGTCCCCGCGCCGCGCCGCGACCTGCAGACCCCGCCGCCGCGCTCGGGCCCGTCTCCCACGCCCCCGCCGCCCCGCGCGCCC
AACTCCGCCGGCCGCCCCGCCCCGCCCCGCGCGCTCCAGACCCCCGGGGCGGCTGCCGGGAGAGATGCTGGAAGAAACTTCTTAAATGAC
CGCGTCTGGCTGGCCGTGGAGCCTTTCTGGGTTGGGGAGAGGAAAGGAAAGTGGAAAAAACCTGAGAACTTCCTGATCTCTCTCGCTGTG
AGACATGTCTGAGACTCCTGCTCAGTGTAGCATTAAGCAGGAACGAATTTCATATACACCTCCAGAGAGCCCAGTGCCGAGTTACGCTTC
CTCGACGCCACTTCATGTTCCAGTGCCTCGAGCGCTCAGGATGGAGGAAGACTCGATCCGCCTGCCTGCGCACCTGCGCTTGCAGCCAAT
TTACTGGAGCAGGGATGACGTAGCCCAGTGGCTCAAGTGGGCTGAAAATGAGTTTTCTTTAAGGCCAATTGACAGCAACACGTTTGAAAT
GAATGGCAAAGCTCTCCTGCTGCTGACCAAAGAGGACTTTCGCTATCGATCTCCTCATTCAGGTGATGTGCTCTATGAACTCCTTCAGCA
TATTCTGAAGCAGAGGAAACCTCGGATTCTTTTTTCACCATTCTTCCACCCTGGAAACTCTATACACACACAGCCGGAGGTCATACTGCA
TCAGAACCATGAAGAAGTTCTTCAGGAGAGAATACCATGGGTACCACCTGAATGCATTGAAAATCCTAAAAATTTAAATTTGGCAACAGA
CAAATGGAGTTTTGGTACCACTTTGTGGGAAATCTGCAGTGGAGGAGATAAACCTCTAAGTGCTCTGGATTCTCAAAGAAAGCTACAATT
TTATGAAGATAGGCATCAGCTTCCTGCACCAAAGTGGGCAGAATTAGCAAACCTTATAAATAATTGTATGGATTATGAACCAGATTTCAG
GCCTTCTTTCAGAGCCATCATACGAGATCTTAACAGTTTGTTTACTCCAGATTATGAACTATTAACAGAAAATGACATGTTACCAAATAT
GAGGATAGGTGCCCTGGGGTTTTCTGGTGCCTTTGAAGACCGGGATCCTACACAGTTTGAAGAGAGACATTTGAAATTTCTACAGCAACT
TGGCAAGGGTAATTTTGGGAGTGTGGAGATGTGCCGGTATGACCCTCTACAGGACAACACTGGGGAGGTGGTCGCTGTAAAAAAGCTTCA
GCATAGTACTGAAGAGCACCTAAGAGACTTTGAAAGGGAAATTGAAATCCTGAAATCCCTACAGCATGACAACATTGTAAAGTACAAGGG
AGTGTGCTACAGTGCTGGTCGGCGTAATCTAAAATTAATTATGGAATATTTACCATATGGAAGTTTACGAGACTATCTTCAAAAACATAA
AGAACGGATAGATCACATAAAACTTCTGCAGTACACATCTCAGATATGCAAGGGTATGGAGTATCTTGGTACAAAAAGGTATATCCACAG
GGATCTGGCAACGAGAAATATATTGGTGGAGAACGAGAACAGAGTTAAAATTGGAGATTTTGGGTTAACCAAAGTCTTGCCACAAGACAA
AGAATACTATAAAGTAAAAGAACCTGGTGAAAGTCCCATATTCTGGTATGCTCCAGAATCACTGACAGAGAGCAAGTTTTCTGTGGCCTC
AGATGTTTGGAGCTTTGGAGTGGTTCTGTATGAACTTTTCACATACATTGAGAAGAGTAAAAGTCCACCAGCGGAATTTATGCGTATGAT
TGGCAATGACAAACAAGGACAGATGATCGTGTTCCATTTGATAGAACTTTTGAAGAATAATGGAAGATTACCAAGACCAGATGGATGCCC
AGATGAGATCTATATGATCATGACAGAATGCTGGAACAATAATGTAAATCAACGCCCCTCCTTTAGGGATCTAGCTCTTCGAGTGGATCA

>27724_27724_2_ETV6-JAK2_ETV6_chr12_12006495_ENST00000396373_JAK2_chr9_5080228_ENST00000539801_length(amino acids)=576AA_BP=154
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN
GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEVLQERIPWVPPECIENPKNLNLATDK
WSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMR
IGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGV
CYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKE
YYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPD

--------------------------------------------------------------
>27724_27724_3_ETV6-JAK2_ETV6_chr12_12006495_ENST00000396373_JAK2_chr9_5080228_ENST00000544510_length(transcript)=2063nt_BP=737nt
GCGTCCCGGGTCCCCGCGCCGCGCCGCGACCTGCAGACCCCGCCGCCGCGCTCGGGCCCGTCTCCCACGCCCCCGCCGCCCCGCGCGCCC
AACTCCGCCGGCCGCCCCGCCCCGCCCCGCGCGCTCCAGACCCCCGGGGCGGCTGCCGGGAGAGATGCTGGAAGAAACTTCTTAAATGAC
CGCGTCTGGCTGGCCGTGGAGCCTTTCTGGGTTGGGGAGAGGAAAGGAAAGTGGAAAAAACCTGAGAACTTCCTGATCTCTCTCGCTGTG
AGACATGTCTGAGACTCCTGCTCAGTGTAGCATTAAGCAGGAACGAATTTCATATACACCTCCAGAGAGCCCAGTGCCGAGTTACGCTTC
CTCGACGCCACTTCATGTTCCAGTGCCTCGAGCGCTCAGGATGGAGGAAGACTCGATCCGCCTGCCTGCGCACCTGCGCTTGCAGCCAAT
TTACTGGAGCAGGGATGACGTAGCCCAGTGGCTCAAGTGGGCTGAAAATGAGTTTTCTTTAAGGCCAATTGACAGCAACACGTTTGAAAT
GAATGGCAAAGCTCTCCTGCTGCTGACCAAAGAGGACTTTCGCTATCGATCTCCTCATTCAGGTGATGTGCTCTATGAACTCCTTCAGCA
TATTCTGAAGCAGAGGAAACCTCGGATTCTTTTTTCACCATTCTTCCACCCTGGAAACTCTATACACACACAGCCGGAGGTCATACTGCA
TCAGAACCATGAAGAAGTTCTTCAGGAGAGAATACCATGGGTACCACCTGAATGCATTGAAAATCCTAAAAATTTAAATTTGGCAACAGA
CAAATGGAGTTTTGGTACCACTTTGTGGGAAATCTGCAGTGGAGGAGATAAACCTCTAAGTGCTCTGGATTCTCAAAGAAAGCTACAATT
TTATGAAGATAGGCATCAGCTTCCTGCACCAAAGTGGGCAGAATTAGCAAACCTTATAAATAATTGTATGGATTATGAACCAGATTTCAG
GCCTTCTTTCAGAGCCATCATACGAGATCTTAACAGTTTGTTTACTCCAGATTATGAACTATTAACAGAAAATGACATGTTACCAAATAT
GAGGATAGGTGCCCTGGGGTTTTCTGGTGCCTTTGAAGACCGGGATCCTACACAGTTTGAAGAGAGACATTTGAAATTTCTACAGCAACT
TGGCAAGGGTAATTTTGGGAGTGTGGAGATGTGCCGGTATGACCCTCTACAGGACAACACTGGGGAGGTGGTCGCTGTAAAAAAGCTTCA
GCATAGTACTGAAGAGCACCTAAGAGACTTTGAAAGGGAAATTGAAATCCTGAAATCCCTACAGCATGACAACATTGTAAAGTACAAGGG
AGTGTGCTACAGTGCTGGTCGGCGTAATCTAAAATTAATTATGGAATATTTACCATATGGAAGTTTACGAGACTATCTTCAAAAACATAA
AGAACGGATAGATCACATAAAACTTCTGCAGTACACATCTCAGATATGCAAGGGTATGGAGTATCTTGGTACAAAAAGGTATATCCACAG
GGATCTGGCAACGAGAAATATATTGGTGGAGAACGAGAACAGAGTTAAAATTGGAGATTTTGGGTTAACCAAAGTCTTGCCACAAGACAA
AGAATACTATAAAGTAAAAGAACCTGGTGAAAGTCCCATATTCTGGTATGCTCCAGAATCACTGACAGAGAGCAAGTTTTCTGTGGCCTC
AGATGTTTGGAGCTTTGGAGTGGTTCTGTATGAACTTTTCACATACATTGAGAAGAGTAAAAGTCCACCAGCGGAATTTATGCGTATGAT
TGGCAATGACAAACAAGGACAGATGATCGTGTTCCATTTGATAGAACTTTTGAAGAATAATGGAAGATTACCAAGACCAGATGGATGCCC
AGATGAGATCTATATGATCATGACAGAATGCTGGAACAATAATGTAAATCAACGCCCCTCCTTTAGGGATCTAGCTCTTCGAGTGGATCA

>27724_27724_3_ETV6-JAK2_ETV6_chr12_12006495_ENST00000396373_JAK2_chr9_5080228_ENST00000544510_length(amino acids)=576AA_BP=154
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN
GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEVLQERIPWVPPECIENPKNLNLATDK
WSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMR
IGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGV
CYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKE
YYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPD

--------------------------------------------------------------
>27724_27724_4_ETV6-JAK2_ETV6_chr12_12022903_ENST00000396373_JAK2_chr9_5069924_ENST00000381652_length(transcript)=4561nt_BP=1283nt
GCGTCCCGGGTCCCCGCGCCGCGCCGCGACCTGCAGACCCCGCCGCCGCGCTCGGGCCCGTCTCCCACGCCCCCGCCGCCCCGCGCGCCC
AACTCCGCCGGCCGCCCCGCCCCGCCCCGCGCGCTCCAGACCCCCGGGGCGGCTGCCGGGAGAGATGCTGGAAGAAACTTCTTAAATGAC
CGCGTCTGGCTGGCCGTGGAGCCTTTCTGGGTTGGGGAGAGGAAAGGAAAGTGGAAAAAACCTGAGAACTTCCTGATCTCTCTCGCTGTG
AGACATGTCTGAGACTCCTGCTCAGTGTAGCATTAAGCAGGAACGAATTTCATATACACCTCCAGAGAGCCCAGTGCCGAGTTACGCTTC
CTCGACGCCACTTCATGTTCCAGTGCCTCGAGCGCTCAGGATGGAGGAAGACTCGATCCGCCTGCCTGCGCACCTGCGCTTGCAGCCAAT
TTACTGGAGCAGGGATGACGTAGCCCAGTGGCTCAAGTGGGCTGAAAATGAGTTTTCTTTAAGGCCAATTGACAGCAACACGTTTGAAAT
GAATGGCAAAGCTCTCCTGCTGCTGACCAAAGAGGACTTTCGCTATCGATCTCCTCATTCAGGTGATGTGCTCTATGAACTCCTTCAGCA
TATTCTGAAGCAGAGGAAACCTCGGATTCTTTTTTCACCATTCTTCCACCCTGGAAACTCTATACACACACAGCCGGAGGTCATACTGCA
TCAGAACCATGAAGAAGATAACTGTGTCCAGAGGACCCCCAGGCCATCCGTGGATAATGTGCACCATAACCCTCCCACCATTGAACTGTT
GCACCGCTCCAGGTCACCTATCACGACAAATCACCGGCCTTCTCCTGACCCCGAGCAGCGGCCCCTCCGGTCCCCCCTGGACAACATGAT
CCGCCGCCTCTCCCCGGCTGAGAGAGCTCAGGGACCCAGGCCGCACCAGGAGAACAACCACCAGGAGTCCTACCCTCTGTCAGTGTCTCC
CATGGAGAATAATCACTGCCCAGCGTCCTCCGAGTCCCACCCGAAGCCATCCAGCCCCCGGCAGGAGAGCACACGCGTGATCCAGCTGAT
GCCCAGCCCCATCATGCACCCTCTGATCCTGAACCCCCGGCACTCCGTGGATTTCAAACAGTCCAGGCTCTCCGAGGACGGGCTGCATAG
GGAAGGGAAGCCCATCAACCTCTCTCATCGGGAAGACCTGGCTTACATGAACCACATCATGGTCTCTGTCTCCCCGCCTGAAGAGCACGC
CATGCCCATTGGGAGAATAGCAGATAAATCAAACCTTCTAGTCTTCAGAACGAATGGTGTTTCTGATGTACCAACCTCACCAACATTACA
GAGGCCTACTCATATGAACCAAATGGTGTTTCACAAAATCAGAAATGAAGATTTGATATTTAATGAAAGCCTTGGCCAAGGCACTTTTAC
AAAGATTTTTAAAGGCGTACGAAGAGAAGTAGGAGACTACGGTCAACTGCATGAAACAGAAGTTCTTTTAAAAGTTCTGGATAAAGCACA
CAGAAACTATTCAGAGTCTTTCTTTGAAGCAGCAAGTATGATGAGCAAGCTTTCTCACAAGCATTTGGTTTTAAATTATGGAGTATGTGT
CTGTGGAGACGAGAATATTCTGGTTCAGGAGTTTGTAAAATTTGGATCACTAGATACATATCTGAAAAAGAATAAAAATTGTATAAATAT
ATTATGGAAACTTGAAGTTGCTAAACAGTTGGCATGGGCCATGCATTTTCTAGAAGAAAACACCCTTATTCATGGGAATGTATGTGCCAA
AAATATTCTGCTTATCAGAGAAGAAGACAGGAAGACAGGAAATCCTCCTTTCATCAAACTTAGTGATCCTGGCATTAGTATTACAGTTTT
GCCAAAGGACATTCTTCAGGAGAGAATACCATGGGTACCACCTGAATGCATTGAAAATCCTAAAAATTTAAATTTGGCAACAGACAAATG
GAGTTTTGGTACCACTTTGTGGGAAATCTGCAGTGGAGGAGATAAACCTCTAAGTGCTCTGGATTCTCAAAGAAAGCTACAATTTTATGA
AGATAGGCATCAGCTTCCTGCACCAAAGTGGGCAGAATTAGCAAACCTTATAAATAATTGTATGGATTATGAACCAGATTTCAGGCCTTC
TTTCAGAGCCATCATACGAGATCTTAACAGTTTGTTTACTCCAGATTATGAACTATTAACAGAAAATGACATGTTACCAAATATGAGGAT
AGGTGCCCTGGGGTTTTCTGGTGCCTTTGAAGACCGGGATCCTACACAGTTTGAAGAGAGACATTTGAAATTTCTACAGCAACTTGGCAA
GGGTAATTTTGGGAGTGTGGAGATGTGCCGGTATGACCCTCTACAGGACAACACTGGGGAGGTGGTCGCTGTAAAAAAGCTTCAGCATAG
TACTGAAGAGCACCTAAGAGACTTTGAAAGGGAAATTGAAATCCTGAAATCCCTACAGCATGACAACATTGTAAAGTACAAGGGAGTGTG
CTACAGTGCTGGTCGGCGTAATCTAAAATTAATTATGGAATATTTACCATATGGAAGTTTACGAGACTATCTTCAAAAACATAAAGAACG
GATAGATCACATAAAACTTCTGCAGTACACATCTCAGATATGCAAGGGTATGGAGTATCTTGGTACAAAAAGGTATATCCACAGGGATCT
GGCAACGAGAAATATATTGGTGGAGAACGAGAACAGAGTTAAAATTGGAGATTTTGGGTTAACCAAAGTCTTGCCACAAGACAAAGAATA
CTATAAAGTAAAAGAACCTGGTGAAAGTCCCATATTCTGGTATGCTCCAGAATCACTGACAGAGAGCAAGTTTTCTGTGGCCTCAGATGT
TTGGAGCTTTGGAGTGGTTCTGTATGAACTTTTCACATACATTGAGAAGAGTAAAAGTCCACCAGCGGAATTTATGCGTATGATTGGCAA
TGACAAACAAGGACAGATGATCGTGTTCCATTTGATAGAACTTTTGAAGAATAATGGAAGATTACCAAGACCAGATGGATGCCCAGATGA
GATCTATATGATCATGACAGAATGCTGGAACAATAATGTAAATCAACGCCCCTCCTTTAGGGATCTAGCTCTTCGAGTGGATCAAATAAG
GGATAACATGGCTGGATGAAAGAAATGACCTTCATTCTGAGACCAAAGTAGATTTACAGAACAAAGTTTTATATTTCACATTGCTGTGGA
CTATTATTACATATATCATTATTATATAAATCATGATGCTAGCCAGCAAAGATGTGAAAATATCTGCTCAAAACTTTCAAAGTTTAGTAA
GTTTTTCTTCATGAGGCCACCAGTAAAAGACATTAATGAGAATTCCTTAGCAAGGATTTTGTAAGAAGTTTCTTAAACATTGTCAGTTAA
CATCACTCTTGTCTGGCAAAAGAAAAAAAATAGACTTTTTCAACTCAGCTTTTTGAGACCTGAAAAAATTATTATGTAAATTTTGCAATG
TTAAAGATGCACAGAATATGTATGTATAGTTTTTACCACAGTGGATGTATAATACCTTGGCATCTTGTGTGATGTTTTACACACATGAGG
GCTGGTGTTCATTAATACTGTTTTCTAATTTTTCCATAGTTAATCTATAATTAATTACTTCACTATACAAACAAATTAAGATGTTCAGAT
AATTGAATAAGTACCTTTGTGTCCTTGTTCATTTATATCGCTGGCCAGCATTATAAGCAGGTGTATACTTTTAGCTTGTAGTTCCATGTA
CTGTAAATATTTTTCACATAAAGGGAACAAATGTCTAGTTTTATTTGTATAGGAAATTTCCCTGACCCTAAATAATACATTTTGAAATGA
AACAAGCTTACAAAGATATAATCTATTTTATTATGGTTTCCCTTGTATCTATTTGTGGTGAATGTGTTTTTTAAATGGAACTATCTCCAA
ATTTTTCTAAGACTACTATGAACAGTTTTCTTTTAAAATTTTGAGATTAAGAATGCCAGGAATATTGTCATCCTTTGAGCTGCTGACTGC
CAATAACATTCTTCGATCTCTGGGATTTATGCTCATGAACTAAATTTAAGCTTAAGCCATAAAATAGATTAGATTGTTTTTTAAAAATGG
ATAGCTCATTAAGAAGTGCAGCAGGTTAAGAATTTTTTCCTAAAGACTGTATATTTGAGGGGTTTCAGAATTTTGCATTGCAGTCATAGA
AGAGATTTATTTCCTTTTTAGAGGGGAAATGAGGTAAATAAGTAAAAAAGTATGCTTGTTAATTTTATTCAAGAATGCCAGTAGAAAATT
CATAACGTGTATCTTTAAGAAAAATGAGCATACATCTTAAATCTTTTCAATTAAGTATAAGGGGTTGTTCGTTGTTGTCATTTGTTATAG
TGCTACTCCACTTTAGACACCATAGCTAAAATAAAATATGGTGGGTTTTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTT

>27724_27724_4_ETV6-JAK2_ETV6_chr12_12022903_ENST00000396373_JAK2_chr9_5069924_ENST00000381652_length(amino acids)=964AA_BP=336
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN
GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDNCVQRTPRPSVDNVHHNPPTIELLH
RSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSESHPKPSSPRQESTRVIQLMP
SPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIADKSNLLVFRTNGVSDVPTSPTLQR
PTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVC
GDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLP
KDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSF
RAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHST
EEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLA
TRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGND

--------------------------------------------------------------
>27724_27724_5_ETV6-JAK2_ETV6_chr12_12022903_ENST00000396373_JAK2_chr9_5069924_ENST00000539801_length(transcript)=3192nt_BP=1283nt
GCGTCCCGGGTCCCCGCGCCGCGCCGCGACCTGCAGACCCCGCCGCCGCGCTCGGGCCCGTCTCCCACGCCCCCGCCGCCCCGCGCGCCC
AACTCCGCCGGCCGCCCCGCCCCGCCCCGCGCGCTCCAGACCCCCGGGGCGGCTGCCGGGAGAGATGCTGGAAGAAACTTCTTAAATGAC
CGCGTCTGGCTGGCCGTGGAGCCTTTCTGGGTTGGGGAGAGGAAAGGAAAGTGGAAAAAACCTGAGAACTTCCTGATCTCTCTCGCTGTG
AGACATGTCTGAGACTCCTGCTCAGTGTAGCATTAAGCAGGAACGAATTTCATATACACCTCCAGAGAGCCCAGTGCCGAGTTACGCTTC
CTCGACGCCACTTCATGTTCCAGTGCCTCGAGCGCTCAGGATGGAGGAAGACTCGATCCGCCTGCCTGCGCACCTGCGCTTGCAGCCAAT
TTACTGGAGCAGGGATGACGTAGCCCAGTGGCTCAAGTGGGCTGAAAATGAGTTTTCTTTAAGGCCAATTGACAGCAACACGTTTGAAAT
GAATGGCAAAGCTCTCCTGCTGCTGACCAAAGAGGACTTTCGCTATCGATCTCCTCATTCAGGTGATGTGCTCTATGAACTCCTTCAGCA
TATTCTGAAGCAGAGGAAACCTCGGATTCTTTTTTCACCATTCTTCCACCCTGGAAACTCTATACACACACAGCCGGAGGTCATACTGCA
TCAGAACCATGAAGAAGATAACTGTGTCCAGAGGACCCCCAGGCCATCCGTGGATAATGTGCACCATAACCCTCCCACCATTGAACTGTT
GCACCGCTCCAGGTCACCTATCACGACAAATCACCGGCCTTCTCCTGACCCCGAGCAGCGGCCCCTCCGGTCCCCCCTGGACAACATGAT
CCGCCGCCTCTCCCCGGCTGAGAGAGCTCAGGGACCCAGGCCGCACCAGGAGAACAACCACCAGGAGTCCTACCCTCTGTCAGTGTCTCC
CATGGAGAATAATCACTGCCCAGCGTCCTCCGAGTCCCACCCGAAGCCATCCAGCCCCCGGCAGGAGAGCACACGCGTGATCCAGCTGAT
GCCCAGCCCCATCATGCACCCTCTGATCCTGAACCCCCGGCACTCCGTGGATTTCAAACAGTCCAGGCTCTCCGAGGACGGGCTGCATAG
GGAAGGGAAGCCCATCAACCTCTCTCATCGGGAAGACCTGGCTTACATGAACCACATCATGGTCTCTGTCTCCCCGCCTGAAGAGCACGC
CATGCCCATTGGGAGAATAGCAGATAAATCAAACCTTCTAGTCTTCAGAACGAATGGTGTTTCTGATGTACCAACCTCACCAACATTACA
GAGGCCTACTCATATGAACCAAATGGTGTTTCACAAAATCAGAAATGAAGATTTGATATTTAATGAAAGCCTTGGCCAAGGCACTTTTAC
AAAGATTTTTAAAGGCGTACGAAGAGAAGTAGGAGACTACGGTCAACTGCATGAAACAGAAGTTCTTTTAAAAGTTCTGGATAAAGCACA
CAGAAACTATTCAGAGTCTTTCTTTGAAGCAGCAAGTATGATGAGCAAGCTTTCTCACAAGCATTTGGTTTTAAATTATGGAGTATGTGT
CTGTGGAGACGAGAATATTCTGGTTCAGGAGTTTGTAAAATTTGGATCACTAGATACATATCTGAAAAAGAATAAAAATTGTATAAATAT
ATTATGGAAACTTGAAGTTGCTAAACAGTTGGCATGGGCCATGCATTTTCTAGAAGAAAACACCCTTATTCATGGGAATGTATGTGCCAA
AAATATTCTGCTTATCAGAGAAGAAGACAGGAAGACAGGAAATCCTCCTTTCATCAAACTTAGTGATCCTGGCATTAGTATTACAGTTTT
GCCAAAGGACATTCTTCAGGAGAGAATACCATGGGTACCACCTGAATGCATTGAAAATCCTAAAAATTTAAATTTGGCAACAGACAAATG
GAGTTTTGGTACCACTTTGTGGGAAATCTGCAGTGGAGGAGATAAACCTCTAAGTGCTCTGGATTCTCAAAGAAAGCTACAATTTTATGA
AGATAGGCATCAGCTTCCTGCACCAAAGTGGGCAGAATTAGCAAACCTTATAAATAATTGTATGGATTATGAACCAGATTTCAGGCCTTC
TTTCAGAGCCATCATACGAGATCTTAACAGTTTGTTTACTCCAGATTATGAACTATTAACAGAAAATGACATGTTACCAAATATGAGGAT
AGGTGCCCTGGGGTTTTCTGGTGCCTTTGAAGACCGGGATCCTACACAGTTTGAAGAGAGACATTTGAAATTTCTACAGCAACTTGGCAA
GGGTAATTTTGGGAGTGTGGAGATGTGCCGGTATGACCCTCTACAGGACAACACTGGGGAGGTGGTCGCTGTAAAAAAGCTTCAGCATAG
TACTGAAGAGCACCTAAGAGACTTTGAAAGGGAAATTGAAATCCTGAAATCCCTACAGCATGACAACATTGTAAAGTACAAGGGAGTGTG
CTACAGTGCTGGTCGGCGTAATCTAAAATTAATTATGGAATATTTACCATATGGAAGTTTACGAGACTATCTTCAAAAACATAAAGAACG
GATAGATCACATAAAACTTCTGCAGTACACATCTCAGATATGCAAGGGTATGGAGTATCTTGGTACAAAAAGGTATATCCACAGGGATCT
GGCAACGAGAAATATATTGGTGGAGAACGAGAACAGAGTTAAAATTGGAGATTTTGGGTTAACCAAAGTCTTGCCACAAGACAAAGAATA
CTATAAAGTAAAAGAACCTGGTGAAAGTCCCATATTCTGGTATGCTCCAGAATCACTGACAGAGAGCAAGTTTTCTGTGGCCTCAGATGT
TTGGAGCTTTGGAGTGGTTCTGTATGAACTTTTCACATACATTGAGAAGAGTAAAAGTCCACCAGCGGAATTTATGCGTATGATTGGCAA
TGACAAACAAGGACAGATGATCGTGTTCCATTTGATAGAACTTTTGAAGAATAATGGAAGATTACCAAGACCAGATGGATGCCCAGATGA
GATCTATATGATCATGACAGAATGCTGGAACAATAATGTAAATCAACGCCCCTCCTTTAGGGATCTAGCTCTTCGAGTGGATCAAATAAG

>27724_27724_5_ETV6-JAK2_ETV6_chr12_12022903_ENST00000396373_JAK2_chr9_5069924_ENST00000539801_length(amino acids)=964AA_BP=336
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN
GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDNCVQRTPRPSVDNVHHNPPTIELLH
RSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSESHPKPSSPRQESTRVIQLMP
SPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIADKSNLLVFRTNGVSDVPTSPTLQR
PTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVC
GDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLP
KDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSF
RAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHST
EEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLA
TRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGND

--------------------------------------------------------------
>27724_27724_6_ETV6-JAK2_ETV6_chr12_12022903_ENST00000396373_JAK2_chr9_5069924_ENST00000544510_length(transcript)=3227nt_BP=1283nt
GCGTCCCGGGTCCCCGCGCCGCGCCGCGACCTGCAGACCCCGCCGCCGCGCTCGGGCCCGTCTCCCACGCCCCCGCCGCCCCGCGCGCCC
AACTCCGCCGGCCGCCCCGCCCCGCCCCGCGCGCTCCAGACCCCCGGGGCGGCTGCCGGGAGAGATGCTGGAAGAAACTTCTTAAATGAC
CGCGTCTGGCTGGCCGTGGAGCCTTTCTGGGTTGGGGAGAGGAAAGGAAAGTGGAAAAAACCTGAGAACTTCCTGATCTCTCTCGCTGTG
AGACATGTCTGAGACTCCTGCTCAGTGTAGCATTAAGCAGGAACGAATTTCATATACACCTCCAGAGAGCCCAGTGCCGAGTTACGCTTC
CTCGACGCCACTTCATGTTCCAGTGCCTCGAGCGCTCAGGATGGAGGAAGACTCGATCCGCCTGCCTGCGCACCTGCGCTTGCAGCCAAT
TTACTGGAGCAGGGATGACGTAGCCCAGTGGCTCAAGTGGGCTGAAAATGAGTTTTCTTTAAGGCCAATTGACAGCAACACGTTTGAAAT
GAATGGCAAAGCTCTCCTGCTGCTGACCAAAGAGGACTTTCGCTATCGATCTCCTCATTCAGGTGATGTGCTCTATGAACTCCTTCAGCA
TATTCTGAAGCAGAGGAAACCTCGGATTCTTTTTTCACCATTCTTCCACCCTGGAAACTCTATACACACACAGCCGGAGGTCATACTGCA
TCAGAACCATGAAGAAGATAACTGTGTCCAGAGGACCCCCAGGCCATCCGTGGATAATGTGCACCATAACCCTCCCACCATTGAACTGTT
GCACCGCTCCAGGTCACCTATCACGACAAATCACCGGCCTTCTCCTGACCCCGAGCAGCGGCCCCTCCGGTCCCCCCTGGACAACATGAT
CCGCCGCCTCTCCCCGGCTGAGAGAGCTCAGGGACCCAGGCCGCACCAGGAGAACAACCACCAGGAGTCCTACCCTCTGTCAGTGTCTCC
CATGGAGAATAATCACTGCCCAGCGTCCTCCGAGTCCCACCCGAAGCCATCCAGCCCCCGGCAGGAGAGCACACGCGTGATCCAGCTGAT
GCCCAGCCCCATCATGCACCCTCTGATCCTGAACCCCCGGCACTCCGTGGATTTCAAACAGTCCAGGCTCTCCGAGGACGGGCTGCATAG
GGAAGGGAAGCCCATCAACCTCTCTCATCGGGAAGACCTGGCTTACATGAACCACATCATGGTCTCTGTCTCCCCGCCTGAAGAGCACGC
CATGCCCATTGGGAGAATAGCAGATAAATCAAACCTTCTAGTCTTCAGAACGAATGGTGTTTCTGATGTACCAACCTCACCAACATTACA
GAGGCCTACTCATATGAACCAAATGGTGTTTCACAAAATCAGAAATGAAGATTTGATATTTAATGAAAGCCTTGGCCAAGGCACTTTTAC
AAAGATTTTTAAAGGCGTACGAAGAGAAGTAGGAGACTACGGTCAACTGCATGAAACAGAAGTTCTTTTAAAAGTTCTGGATAAAGCACA
CAGAAACTATTCAGAGTCTTTCTTTGAAGCAGCAAGTATGATGAGCAAGCTTTCTCACAAGCATTTGGTTTTAAATTATGGAGTATGTGT
CTGTGGAGACGAGAATATTCTGGTTCAGGAGTTTGTAAAATTTGGATCACTAGATACATATCTGAAAAAGAATAAAAATTGTATAAATAT
ATTATGGAAACTTGAAGTTGCTAAACAGTTGGCATGGGCCATGCATTTTCTAGAAGAAAACACCCTTATTCATGGGAATGTATGTGCCAA
AAATATTCTGCTTATCAGAGAAGAAGACAGGAAGACAGGAAATCCTCCTTTCATCAAACTTAGTGATCCTGGCATTAGTATTACAGTTTT
GCCAAAGGACATTCTTCAGGAGAGAATACCATGGGTACCACCTGAATGCATTGAAAATCCTAAAAATTTAAATTTGGCAACAGACAAATG
GAGTTTTGGTACCACTTTGTGGGAAATCTGCAGTGGAGGAGATAAACCTCTAAGTGCTCTGGATTCTCAAAGAAAGCTACAATTTTATGA
AGATAGGCATCAGCTTCCTGCACCAAAGTGGGCAGAATTAGCAAACCTTATAAATAATTGTATGGATTATGAACCAGATTTCAGGCCTTC
TTTCAGAGCCATCATACGAGATCTTAACAGTTTGTTTACTCCAGATTATGAACTATTAACAGAAAATGACATGTTACCAAATATGAGGAT
AGGTGCCCTGGGGTTTTCTGGTGCCTTTGAAGACCGGGATCCTACACAGTTTGAAGAGAGACATTTGAAATTTCTACAGCAACTTGGCAA
GGGTAATTTTGGGAGTGTGGAGATGTGCCGGTATGACCCTCTACAGGACAACACTGGGGAGGTGGTCGCTGTAAAAAAGCTTCAGCATAG
TACTGAAGAGCACCTAAGAGACTTTGAAAGGGAAATTGAAATCCTGAAATCCCTACAGCATGACAACATTGTAAAGTACAAGGGAGTGTG
CTACAGTGCTGGTCGGCGTAATCTAAAATTAATTATGGAATATTTACCATATGGAAGTTTACGAGACTATCTTCAAAAACATAAAGAACG
GATAGATCACATAAAACTTCTGCAGTACACATCTCAGATATGCAAGGGTATGGAGTATCTTGGTACAAAAAGGTATATCCACAGGGATCT
GGCAACGAGAAATATATTGGTGGAGAACGAGAACAGAGTTAAAATTGGAGATTTTGGGTTAACCAAAGTCTTGCCACAAGACAAAGAATA
CTATAAAGTAAAAGAACCTGGTGAAAGTCCCATATTCTGGTATGCTCCAGAATCACTGACAGAGAGCAAGTTTTCTGTGGCCTCAGATGT
TTGGAGCTTTGGAGTGGTTCTGTATGAACTTTTCACATACATTGAGAAGAGTAAAAGTCCACCAGCGGAATTTATGCGTATGATTGGCAA
TGACAAACAAGGACAGATGATCGTGTTCCATTTGATAGAACTTTTGAAGAATAATGGAAGATTACCAAGACCAGATGGATGCCCAGATGA
GATCTATATGATCATGACAGAATGCTGGAACAATAATGTAAATCAACGCCCCTCCTTTAGGGATCTAGCTCTTCGAGTGGATCAAATAAG

>27724_27724_6_ETV6-JAK2_ETV6_chr12_12022903_ENST00000396373_JAK2_chr9_5069924_ENST00000544510_length(amino acids)=964AA_BP=336
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN
GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDNCVQRTPRPSVDNVHHNPPTIELLH
RSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSESHPKPSSPRQESTRVIQLMP
SPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIADKSNLLVFRTNGVSDVPTSPTLQR
PTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVC
GDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLP
KDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSF
RAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHST
EEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLA
TRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGND

--------------------------------------------------------------
>27724_27724_7_ETV6-JAK2_ETV6_chr12_12022903_ENST00000396373_JAK2_chr9_5081724_ENST00000381652_length(transcript)=3640nt_BP=1283nt
GCGTCCCGGGTCCCCGCGCCGCGCCGCGACCTGCAGACCCCGCCGCCGCGCTCGGGCCCGTCTCCCACGCCCCCGCCGCCCCGCGCGCCC
AACTCCGCCGGCCGCCCCGCCCCGCCCCGCGCGCTCCAGACCCCCGGGGCGGCTGCCGGGAGAGATGCTGGAAGAAACTTCTTAAATGAC
CGCGTCTGGCTGGCCGTGGAGCCTTTCTGGGTTGGGGAGAGGAAAGGAAAGTGGAAAAAACCTGAGAACTTCCTGATCTCTCTCGCTGTG
AGACATGTCTGAGACTCCTGCTCAGTGTAGCATTAAGCAGGAACGAATTTCATATACACCTCCAGAGAGCCCAGTGCCGAGTTACGCTTC
CTCGACGCCACTTCATGTTCCAGTGCCTCGAGCGCTCAGGATGGAGGAAGACTCGATCCGCCTGCCTGCGCACCTGCGCTTGCAGCCAAT
TTACTGGAGCAGGGATGACGTAGCCCAGTGGCTCAAGTGGGCTGAAAATGAGTTTTCTTTAAGGCCAATTGACAGCAACACGTTTGAAAT
GAATGGCAAAGCTCTCCTGCTGCTGACCAAAGAGGACTTTCGCTATCGATCTCCTCATTCAGGTGATGTGCTCTATGAACTCCTTCAGCA
TATTCTGAAGCAGAGGAAACCTCGGATTCTTTTTTCACCATTCTTCCACCCTGGAAACTCTATACACACACAGCCGGAGGTCATACTGCA
TCAGAACCATGAAGAAGATAACTGTGTCCAGAGGACCCCCAGGCCATCCGTGGATAATGTGCACCATAACCCTCCCACCATTGAACTGTT
GCACCGCTCCAGGTCACCTATCACGACAAATCACCGGCCTTCTCCTGACCCCGAGCAGCGGCCCCTCCGGTCCCCCCTGGACAACATGAT
CCGCCGCCTCTCCCCGGCTGAGAGAGCTCAGGGACCCAGGCCGCACCAGGAGAACAACCACCAGGAGTCCTACCCTCTGTCAGTGTCTCC
CATGGAGAATAATCACTGCCCAGCGTCCTCCGAGTCCCACCCGAAGCCATCCAGCCCCCGGCAGGAGAGCACACGCGTGATCCAGCTGAT
GCCCAGCCCCATCATGCACCCTCTGATCCTGAACCCCCGGCACTCCGTGGATTTCAAACAGTCCAGGCTCTCCGAGGACGGGCTGCATAG
GGAAGGGAAGCCCATCAACCTCTCTCATCGGGAAGACCTGGCTTACATGAACCACATCATGGTCTCTGTCTCCCCGCCTGAAGAGCACGC
CATGCCCATTGGGAGAATAGCAGATTATGAACTATTAACAGAAAATGACATGTTACCAAATATGAGGATAGGTGCCCTGGGGTTTTCTGG
TGCCTTTGAAGACCGGGATCCTACACAGTTTGAAGAGAGACATTTGAAATTTCTACAGCAACTTGGCAAGGGTAATTTTGGGAGTGTGGA
GATGTGCCGGTATGACCCTCTACAGGACAACACTGGGGAGGTGGTCGCTGTAAAAAAGCTTCAGCATAGTACTGAAGAGCACCTAAGAGA
CTTTGAAAGGGAAATTGAAATCCTGAAATCCCTACAGCATGACAACATTGTAAAGTACAAGGGAGTGTGCTACAGTGCTGGTCGGCGTAA
TCTAAAATTAATTATGGAATATTTACCATATGGAAGTTTACGAGACTATCTTCAAAAACATAAAGAACGGATAGATCACATAAAACTTCT
GCAGTACACATCTCAGATATGCAAGGGTATGGAGTATCTTGGTACAAAAAGGTATATCCACAGGGATCTGGCAACGAGAAATATATTGGT
GGAGAACGAGAACAGAGTTAAAATTGGAGATTTTGGGTTAACCAAAGTCTTGCCACAAGACAAAGAATACTATAAAGTAAAAGAACCTGG
TGAAAGTCCCATATTCTGGTATGCTCCAGAATCACTGACAGAGAGCAAGTTTTCTGTGGCCTCAGATGTTTGGAGCTTTGGAGTGGTTCT
GTATGAACTTTTCACATACATTGAGAAGAGTAAAAGTCCACCAGCGGAATTTATGCGTATGATTGGCAATGACAAACAAGGACAGATGAT
CGTGTTCCATTTGATAGAACTTTTGAAGAATAATGGAAGATTACCAAGACCAGATGGATGCCCAGATGAGATCTATATGATCATGACAGA
ATGCTGGAACAATAATGTAAATCAACGCCCCTCCTTTAGGGATCTAGCTCTTCGAGTGGATCAAATAAGGGATAACATGGCTGGATGAAA
GAAATGACCTTCATTCTGAGACCAAAGTAGATTTACAGAACAAAGTTTTATATTTCACATTGCTGTGGACTATTATTACATATATCATTA
TTATATAAATCATGATGCTAGCCAGCAAAGATGTGAAAATATCTGCTCAAAACTTTCAAAGTTTAGTAAGTTTTTCTTCATGAGGCCACC
AGTAAAAGACATTAATGAGAATTCCTTAGCAAGGATTTTGTAAGAAGTTTCTTAAACATTGTCAGTTAACATCACTCTTGTCTGGCAAAA
GAAAAAAAATAGACTTTTTCAACTCAGCTTTTTGAGACCTGAAAAAATTATTATGTAAATTTTGCAATGTTAAAGATGCACAGAATATGT
ATGTATAGTTTTTACCACAGTGGATGTATAATACCTTGGCATCTTGTGTGATGTTTTACACACATGAGGGCTGGTGTTCATTAATACTGT
TTTCTAATTTTTCCATAGTTAATCTATAATTAATTACTTCACTATACAAACAAATTAAGATGTTCAGATAATTGAATAAGTACCTTTGTG
TCCTTGTTCATTTATATCGCTGGCCAGCATTATAAGCAGGTGTATACTTTTAGCTTGTAGTTCCATGTACTGTAAATATTTTTCACATAA
AGGGAACAAATGTCTAGTTTTATTTGTATAGGAAATTTCCCTGACCCTAAATAATACATTTTGAAATGAAACAAGCTTACAAAGATATAA
TCTATTTTATTATGGTTTCCCTTGTATCTATTTGTGGTGAATGTGTTTTTTAAATGGAACTATCTCCAAATTTTTCTAAGACTACTATGA
ACAGTTTTCTTTTAAAATTTTGAGATTAAGAATGCCAGGAATATTGTCATCCTTTGAGCTGCTGACTGCCAATAACATTCTTCGATCTCT
GGGATTTATGCTCATGAACTAAATTTAAGCTTAAGCCATAAAATAGATTAGATTGTTTTTTAAAAATGGATAGCTCATTAAGAAGTGCAG
CAGGTTAAGAATTTTTTCCTAAAGACTGTATATTTGAGGGGTTTCAGAATTTTGCATTGCAGTCATAGAAGAGATTTATTTCCTTTTTAG
AGGGGAAATGAGGTAAATAAGTAAAAAAGTATGCTTGTTAATTTTATTCAAGAATGCCAGTAGAAAATTCATAACGTGTATCTTTAAGAA
AAATGAGCATACATCTTAAATCTTTTCAATTAAGTATAAGGGGTTGTTCGTTGTTGTCATTTGTTATAGTGCTACTCCACTTTAGACACC
ATAGCTAAAATAAAATATGGTGGGTTTTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTTATTTATACAAAACTTAAAATA

>27724_27724_7_ETV6-JAK2_ETV6_chr12_12022903_ENST00000396373_JAK2_chr9_5081724_ENST00000381652_length(amino acids)=657AA_BP=336
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN
GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDNCVQRTPRPSVDNVHHNPPTIELLH
RSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSESHPKPSSPRQESTRVIQLMP
SPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIADYELLTENDMLPNMRIGALGFSGA
FEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNL
KLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGE
SPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTEC

--------------------------------------------------------------
>27724_27724_8_ETV6-JAK2_ETV6_chr12_12022903_ENST00000396373_JAK2_chr9_5081724_ENST00000539801_length(transcript)=2271nt_BP=1283nt
GCGTCCCGGGTCCCCGCGCCGCGCCGCGACCTGCAGACCCCGCCGCCGCGCTCGGGCCCGTCTCCCACGCCCCCGCCGCCCCGCGCGCCC
AACTCCGCCGGCCGCCCCGCCCCGCCCCGCGCGCTCCAGACCCCCGGGGCGGCTGCCGGGAGAGATGCTGGAAGAAACTTCTTAAATGAC
CGCGTCTGGCTGGCCGTGGAGCCTTTCTGGGTTGGGGAGAGGAAAGGAAAGTGGAAAAAACCTGAGAACTTCCTGATCTCTCTCGCTGTG
AGACATGTCTGAGACTCCTGCTCAGTGTAGCATTAAGCAGGAACGAATTTCATATACACCTCCAGAGAGCCCAGTGCCGAGTTACGCTTC
CTCGACGCCACTTCATGTTCCAGTGCCTCGAGCGCTCAGGATGGAGGAAGACTCGATCCGCCTGCCTGCGCACCTGCGCTTGCAGCCAAT
TTACTGGAGCAGGGATGACGTAGCCCAGTGGCTCAAGTGGGCTGAAAATGAGTTTTCTTTAAGGCCAATTGACAGCAACACGTTTGAAAT
GAATGGCAAAGCTCTCCTGCTGCTGACCAAAGAGGACTTTCGCTATCGATCTCCTCATTCAGGTGATGTGCTCTATGAACTCCTTCAGCA
TATTCTGAAGCAGAGGAAACCTCGGATTCTTTTTTCACCATTCTTCCACCCTGGAAACTCTATACACACACAGCCGGAGGTCATACTGCA
TCAGAACCATGAAGAAGATAACTGTGTCCAGAGGACCCCCAGGCCATCCGTGGATAATGTGCACCATAACCCTCCCACCATTGAACTGTT
GCACCGCTCCAGGTCACCTATCACGACAAATCACCGGCCTTCTCCTGACCCCGAGCAGCGGCCCCTCCGGTCCCCCCTGGACAACATGAT
CCGCCGCCTCTCCCCGGCTGAGAGAGCTCAGGGACCCAGGCCGCACCAGGAGAACAACCACCAGGAGTCCTACCCTCTGTCAGTGTCTCC
CATGGAGAATAATCACTGCCCAGCGTCCTCCGAGTCCCACCCGAAGCCATCCAGCCCCCGGCAGGAGAGCACACGCGTGATCCAGCTGAT
GCCCAGCCCCATCATGCACCCTCTGATCCTGAACCCCCGGCACTCCGTGGATTTCAAACAGTCCAGGCTCTCCGAGGACGGGCTGCATAG
GGAAGGGAAGCCCATCAACCTCTCTCATCGGGAAGACCTGGCTTACATGAACCACATCATGGTCTCTGTCTCCCCGCCTGAAGAGCACGC
CATGCCCATTGGGAGAATAGCAGATTATGAACTATTAACAGAAAATGACATGTTACCAAATATGAGGATAGGTGCCCTGGGGTTTTCTGG
TGCCTTTGAAGACCGGGATCCTACACAGTTTGAAGAGAGACATTTGAAATTTCTACAGCAACTTGGCAAGGGTAATTTTGGGAGTGTGGA
GATGTGCCGGTATGACCCTCTACAGGACAACACTGGGGAGGTGGTCGCTGTAAAAAAGCTTCAGCATAGTACTGAAGAGCACCTAAGAGA
CTTTGAAAGGGAAATTGAAATCCTGAAATCCCTACAGCATGACAACATTGTAAAGTACAAGGGAGTGTGCTACAGTGCTGGTCGGCGTAA
TCTAAAATTAATTATGGAATATTTACCATATGGAAGTTTACGAGACTATCTTCAAAAACATAAAGAACGGATAGATCACATAAAACTTCT
GCAGTACACATCTCAGATATGCAAGGGTATGGAGTATCTTGGTACAAAAAGGTATATCCACAGGGATCTGGCAACGAGAAATATATTGGT
GGAGAACGAGAACAGAGTTAAAATTGGAGATTTTGGGTTAACCAAAGTCTTGCCACAAGACAAAGAATACTATAAAGTAAAAGAACCTGG
TGAAAGTCCCATATTCTGGTATGCTCCAGAATCACTGACAGAGAGCAAGTTTTCTGTGGCCTCAGATGTTTGGAGCTTTGGAGTGGTTCT
GTATGAACTTTTCACATACATTGAGAAGAGTAAAAGTCCACCAGCGGAATTTATGCGTATGATTGGCAATGACAAACAAGGACAGATGAT
CGTGTTCCATTTGATAGAACTTTTGAAGAATAATGGAAGATTACCAAGACCAGATGGATGCCCAGATGAGATCTATATGATCATGACAGA
ATGCTGGAACAATAATGTAAATCAACGCCCCTCCTTTAGGGATCTAGCTCTTCGAGTGGATCAAATAAGGGATAACATGGCTGGATGAAA

>27724_27724_8_ETV6-JAK2_ETV6_chr12_12022903_ENST00000396373_JAK2_chr9_5081724_ENST00000539801_length(amino acids)=657AA_BP=336
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN
GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDNCVQRTPRPSVDNVHHNPPTIELLH
RSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSESHPKPSSPRQESTRVIQLMP
SPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIADYELLTENDMLPNMRIGALGFSGA
FEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNL
KLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGE
SPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTEC

--------------------------------------------------------------
>27724_27724_9_ETV6-JAK2_ETV6_chr12_12022903_ENST00000396373_JAK2_chr9_5081724_ENST00000544510_length(transcript)=2306nt_BP=1283nt
GCGTCCCGGGTCCCCGCGCCGCGCCGCGACCTGCAGACCCCGCCGCCGCGCTCGGGCCCGTCTCCCACGCCCCCGCCGCCCCGCGCGCCC
AACTCCGCCGGCCGCCCCGCCCCGCCCCGCGCGCTCCAGACCCCCGGGGCGGCTGCCGGGAGAGATGCTGGAAGAAACTTCTTAAATGAC
CGCGTCTGGCTGGCCGTGGAGCCTTTCTGGGTTGGGGAGAGGAAAGGAAAGTGGAAAAAACCTGAGAACTTCCTGATCTCTCTCGCTGTG
AGACATGTCTGAGACTCCTGCTCAGTGTAGCATTAAGCAGGAACGAATTTCATATACACCTCCAGAGAGCCCAGTGCCGAGTTACGCTTC
CTCGACGCCACTTCATGTTCCAGTGCCTCGAGCGCTCAGGATGGAGGAAGACTCGATCCGCCTGCCTGCGCACCTGCGCTTGCAGCCAAT
TTACTGGAGCAGGGATGACGTAGCCCAGTGGCTCAAGTGGGCTGAAAATGAGTTTTCTTTAAGGCCAATTGACAGCAACACGTTTGAAAT
GAATGGCAAAGCTCTCCTGCTGCTGACCAAAGAGGACTTTCGCTATCGATCTCCTCATTCAGGTGATGTGCTCTATGAACTCCTTCAGCA
TATTCTGAAGCAGAGGAAACCTCGGATTCTTTTTTCACCATTCTTCCACCCTGGAAACTCTATACACACACAGCCGGAGGTCATACTGCA
TCAGAACCATGAAGAAGATAACTGTGTCCAGAGGACCCCCAGGCCATCCGTGGATAATGTGCACCATAACCCTCCCACCATTGAACTGTT
GCACCGCTCCAGGTCACCTATCACGACAAATCACCGGCCTTCTCCTGACCCCGAGCAGCGGCCCCTCCGGTCCCCCCTGGACAACATGAT
CCGCCGCCTCTCCCCGGCTGAGAGAGCTCAGGGACCCAGGCCGCACCAGGAGAACAACCACCAGGAGTCCTACCCTCTGTCAGTGTCTCC
CATGGAGAATAATCACTGCCCAGCGTCCTCCGAGTCCCACCCGAAGCCATCCAGCCCCCGGCAGGAGAGCACACGCGTGATCCAGCTGAT
GCCCAGCCCCATCATGCACCCTCTGATCCTGAACCCCCGGCACTCCGTGGATTTCAAACAGTCCAGGCTCTCCGAGGACGGGCTGCATAG
GGAAGGGAAGCCCATCAACCTCTCTCATCGGGAAGACCTGGCTTACATGAACCACATCATGGTCTCTGTCTCCCCGCCTGAAGAGCACGC
CATGCCCATTGGGAGAATAGCAGATTATGAACTATTAACAGAAAATGACATGTTACCAAATATGAGGATAGGTGCCCTGGGGTTTTCTGG
TGCCTTTGAAGACCGGGATCCTACACAGTTTGAAGAGAGACATTTGAAATTTCTACAGCAACTTGGCAAGGGTAATTTTGGGAGTGTGGA
GATGTGCCGGTATGACCCTCTACAGGACAACACTGGGGAGGTGGTCGCTGTAAAAAAGCTTCAGCATAGTACTGAAGAGCACCTAAGAGA
CTTTGAAAGGGAAATTGAAATCCTGAAATCCCTACAGCATGACAACATTGTAAAGTACAAGGGAGTGTGCTACAGTGCTGGTCGGCGTAA
TCTAAAATTAATTATGGAATATTTACCATATGGAAGTTTACGAGACTATCTTCAAAAACATAAAGAACGGATAGATCACATAAAACTTCT
GCAGTACACATCTCAGATATGCAAGGGTATGGAGTATCTTGGTACAAAAAGGTATATCCACAGGGATCTGGCAACGAGAAATATATTGGT
GGAGAACGAGAACAGAGTTAAAATTGGAGATTTTGGGTTAACCAAAGTCTTGCCACAAGACAAAGAATACTATAAAGTAAAAGAACCTGG
TGAAAGTCCCATATTCTGGTATGCTCCAGAATCACTGACAGAGAGCAAGTTTTCTGTGGCCTCAGATGTTTGGAGCTTTGGAGTGGTTCT
GTATGAACTTTTCACATACATTGAGAAGAGTAAAAGTCCACCAGCGGAATTTATGCGTATGATTGGCAATGACAAACAAGGACAGATGAT
CGTGTTCCATTTGATAGAACTTTTGAAGAATAATGGAAGATTACCAAGACCAGATGGATGCCCAGATGAGATCTATATGATCATGACAGA
ATGCTGGAACAATAATGTAAATCAACGCCCCTCCTTTAGGGATCTAGCTCTTCGAGTGGATCAAATAAGGGATAACATGGCTGGATGAAA

>27724_27724_9_ETV6-JAK2_ETV6_chr12_12022903_ENST00000396373_JAK2_chr9_5081724_ENST00000544510_length(amino acids)=657AA_BP=336
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN
GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDNCVQRTPRPSVDNVHHNPPTIELLH
RSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSESHPKPSSPRQESTRVIQLMP
SPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIADYELLTENDMLPNMRIGALGFSGA
FEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNL
KLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGE
SPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTEC

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for ETV6-JAK2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for ETV6-JAK2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for ETV6-JAK2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source