FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:ETV6-LOH12CR1 (FusionGDB2 ID:27726)

Fusion Gene Summary for ETV6-LOH12CR1

check button Fusion gene summary
Fusion gene informationFusion gene name: ETV6-LOH12CR1
Fusion gene ID: 27726
HgeneTgene
Gene symbol

ETV6

LOH12CR1

Gene ID

2120

118426

Gene nameETS variant transcription factor 6BLOC-1 related complex subunit 5
SynonymsTEL|TEL/ABL|THC5LOH12CR1|LOH1CR12
Cytomap

12p13.2

12p13.2

Type of geneprotein-codingprotein-coding
Descriptiontranscription factor ETV6ETS translocation variant 6ETS variant 6ETS-related protein Tel1TEL1 oncogeneets variant gene 6 (TEL oncogene)BLOC-1-related complex subunit 5loss of heterozygosity 12 chromosomal region 1 proteinloss of heterozygosity, 12, chromosomal region 1myristoylated lysosomal proteinmyrlysin
Modification date2020031320200313
UniProtAcc

P41212

.
Ensembl transtripts involved in fusion geneENST00000544715, ENST00000396373, 
ENST00000298571, ENST00000314565, 
ENST00000542728, 
Fusion gene scores* DoF score59 X 37 X 25=545757 X 3 X 6=126
# samples 588
** MAII scorelog2(58/54575*10)=-6.55604351475058
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/126*10)=-0.655351828612554
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ETV6 [Title/Abstract] AND LOH12CR1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointETV6(11905513)-LOH12CR1(12588561), # samples:1
ETV6(11803094)-LOH12CR1(12588561), # samples:1
ETV6(11905513)-LOH12CR1(12588562), # samples:1
ETV6(11803094)-LOH12CR1(12588562), # samples:1
Anticipated loss of major functional domain due to fusion event.ETV6-LOH12CR1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
ETV6-LOH12CR1 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
ETV6-LOH12CR1 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneETV6

GO:0000122

negative regulation of transcription by RNA polymerase II

10514502


check buttonFusion gene breakpoints across ETV6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across LOH12CR1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-LL-A441-01AETV6chr12

11905513

+LOH12CR1chr12

12588562

+
ChimerDB4BRCATCGA-LL-A441ETV6chr12

11905513

+LOH12CR1chr12

12588561

+
ChimerDB4LUSCTCGA-34-A5IXETV6chr12

11803094

+LOH12CR1chr12

12588561

+
ChimerDB4LUSCTCGA-34-A5IXETV6chr12

11803094

+LOH12CR1chr12

12588562

+


Top

Fusion Gene ORF analysis for ETV6-LOH12CR1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000544715ENST00000298571ETV6chr12

11905513

+LOH12CR1chr12

12588562

+
3UTR-3CDSENST00000544715ENST00000298571ETV6chr12

11905513

+LOH12CR1chr12

12588561

+
3UTR-3CDSENST00000544715ENST00000298571ETV6chr12

11803094

+LOH12CR1chr12

12588561

+
3UTR-3CDSENST00000544715ENST00000298571ETV6chr12

11803094

+LOH12CR1chr12

12588562

+
3UTR-3CDSENST00000544715ENST00000314565ETV6chr12

11905513

+LOH12CR1chr12

12588562

+
3UTR-3CDSENST00000544715ENST00000314565ETV6chr12

11905513

+LOH12CR1chr12

12588561

+
3UTR-3CDSENST00000544715ENST00000314565ETV6chr12

11803094

+LOH12CR1chr12

12588561

+
3UTR-3CDSENST00000544715ENST00000314565ETV6chr12

11803094

+LOH12CR1chr12

12588562

+
3UTR-3CDSENST00000544715ENST00000542728ETV6chr12

11905513

+LOH12CR1chr12

12588562

+
3UTR-3CDSENST00000544715ENST00000542728ETV6chr12

11905513

+LOH12CR1chr12

12588561

+
3UTR-3CDSENST00000544715ENST00000542728ETV6chr12

11803094

+LOH12CR1chr12

12588561

+
3UTR-3CDSENST00000544715ENST00000542728ETV6chr12

11803094

+LOH12CR1chr12

12588562

+
Frame-shiftENST00000396373ENST00000298571ETV6chr12

11803094

+LOH12CR1chr12

12588561

+
Frame-shiftENST00000396373ENST00000298571ETV6chr12

11803094

+LOH12CR1chr12

12588562

+
Frame-shiftENST00000396373ENST00000314565ETV6chr12

11803094

+LOH12CR1chr12

12588561

+
Frame-shiftENST00000396373ENST00000314565ETV6chr12

11803094

+LOH12CR1chr12

12588562

+
Frame-shiftENST00000396373ENST00000542728ETV6chr12

11803094

+LOH12CR1chr12

12588561

+
Frame-shiftENST00000396373ENST00000542728ETV6chr12

11803094

+LOH12CR1chr12

12588562

+
In-frameENST00000396373ENST00000298571ETV6chr12

11905513

+LOH12CR1chr12

12588562

+
In-frameENST00000396373ENST00000298571ETV6chr12

11905513

+LOH12CR1chr12

12588561

+
In-frameENST00000396373ENST00000314565ETV6chr12

11905513

+LOH12CR1chr12

12588562

+
In-frameENST00000396373ENST00000314565ETV6chr12

11905513

+LOH12CR1chr12

12588561

+
In-frameENST00000396373ENST00000542728ETV6chr12

11905513

+LOH12CR1chr12

12588562

+
In-frameENST00000396373ENST00000542728ETV6chr12

11905513

+LOH12CR1chr12

12588561

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000396373ETV6chr1211905513+ENST00000542728LOH12CR1chr1212588561+833437274825183
ENST00000396373ETV6chr1211905513+ENST00000314565LOH12CR1chr1212588561+19564371152439237
ENST00000396373ETV6chr1211905513+ENST00000298571LOH12CR1chr1212588561+894437274825183
ENST00000396373ETV6chr1211905513+ENST00000542728LOH12CR1chr1212588562+833437274825183
ENST00000396373ETV6chr1211905513+ENST00000314565LOH12CR1chr1212588562+19564371152439237
ENST00000396373ETV6chr1211905513+ENST00000298571LOH12CR1chr1212588562+894437274825183

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000396373ENST00000542728ETV6chr1211905513+LOH12CR1chr1212588561+0.0049637810.9950362
ENST00000396373ENST00000314565ETV6chr1211905513+LOH12CR1chr1212588561+0.0088894610.99111056
ENST00000396373ENST00000298571ETV6chr1211905513+LOH12CR1chr1212588561+0.0093924570.9906075
ENST00000396373ENST00000542728ETV6chr1211905513+LOH12CR1chr1212588562+0.0049637810.9950362
ENST00000396373ENST00000314565ETV6chr1211905513+LOH12CR1chr1212588562+0.0088894610.99111056
ENST00000396373ENST00000298571ETV6chr1211905513+LOH12CR1chr1212588562+0.0093924570.9906075

Top

Fusion Genomic Features for ETV6-LOH12CR1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ETV6chr1211905513+LOH12CR1chr1212588561+8.49E-060.99999154
ETV6chr1211905513+LOH12CR1chr1212588561+8.49E-060.99999154
ETV6chr1211803094+LOH12CR1chr1212588561+2.77E-060.99999726
ETV6chr1211905513+LOH12CR1chr1212588561+8.49E-060.99999154
ETV6chr1211905513+LOH12CR1chr1212588561+8.49E-060.99999154
ETV6chr1211803094+LOH12CR1chr1212588561+2.77E-060.99999726

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for ETV6-LOH12CR1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:11905513/chr12:12588561)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ETV6

P41212

.
FUNCTION: Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. Plays a role in hematopoiesis and malignant transformation. {ECO:0000269|PubMed:25581430}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneETV6chr12:11905513chr12:12588561ENST00000396373+28339_42054453.0DNA bindingETS
HgeneETV6chr12:11905513chr12:12588562ENST00000396373+28339_42054453.0DNA bindingETS
HgeneETV6chr12:11905513chr12:12588561ENST00000396373+2840_12454453.0DomainPNT
HgeneETV6chr12:11905513chr12:12588562ENST00000396373+2840_12454453.0DomainPNT


Top

Fusion Gene Sequence for ETV6-LOH12CR1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>27726_27726_1_ETV6-LOH12CR1_ETV6_chr12_11905513_ENST00000396373_LOH12CR1_chr12_12588561_ENST00000298571_length(transcript)=894nt_BP=437nt
GCGTCCCGGGTCCCCGCGCCGCGCCGCGACCTGCAGACCCCGCCGCCGCGCTCGGGCCCGTCTCCCACGCCCCCGCCGCCCCGCGCGCCC
AACTCCGCCGGCCGCCCCGCCCCGCCCCGCGCGCTCCAGACCCCCGGGGCGGCTGCCGGGAGAGATGCTGGAAGAAACTTCTTAAATGAC
CGCGTCTGGCTGGCCGTGGAGCCTTTCTGGGTTGGGGAGAGGAAAGGAAAGTGGAAAAAACCTGAGAACTTCCTGATCTCTCTCGCTGTG
AGACATGTCTGAGACTCCTGCTCAGTGTAGCATTAAGCAGGAACGAATTTCATATACACCTCCAGAGAGCCCAGTGCCGAGTTACGCTTC
CTCGACGCCACTTCATGTTCCAGTGCCTCGAGCGCTCAGGATGGAGGAAGACTCGATCCGCCTGCCTGCGCACCTGCGGCTATTGAGTGG
CCAGACTTCCCCAACAAATGCCAAATTGGAGAAACTGGACTCTCAGCAGGTGTTGCAGCTCTGCCTCCGATATCAAGATCACCTGCATCA
GTGTGCAGAGGCCGTTGCTTTTGACCAGAATGCTTTGGTTAAACGAATCAAAGAGATGGATCTGTCTGTAGAAACTCTGTTCAGCTTCAT
GCAGGAGCGCCAGAAAAGATACGCCAAGTATGCCGAGCAGATCCAGAAAGTGAACGAGATGTCCGCCATCCTCCGCCGCATACAGATGGG
CATCGACCAGACTGTGCCCCTGCTGGACAGGCTCAACAGCATGCTGCCCGAGGGCGAGCGGCTGGAGCCCTTCAGCATGAAGCCCGACCG

>27726_27726_1_ETV6-LOH12CR1_ETV6_chr12_11905513_ENST00000396373_LOH12CR1_chr12_12588561_ENST00000298571_length(amino acids)=183AA_BP=0
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLLSGQTSPTNAKLEKLDSQQVLQLCLRYQDHLHQC
AEAVAFDQNALVKRIKEMDLSVETLFSFMQERQKRYAKYAEQIQKVNEMSAILRRIQMGIDQTVPLLDRLNSMLPEGERLEPFSMKPDRE

--------------------------------------------------------------
>27726_27726_2_ETV6-LOH12CR1_ETV6_chr12_11905513_ENST00000396373_LOH12CR1_chr12_12588561_ENST00000314565_length(transcript)=1956nt_BP=437nt
GCGTCCCGGGTCCCCGCGCCGCGCCGCGACCTGCAGACCCCGCCGCCGCGCTCGGGCCCGTCTCCCACGCCCCCGCCGCCCCGCGCGCCC
AACTCCGCCGGCCGCCCCGCCCCGCCCCGCGCGCTCCAGACCCCCGGGGCGGCTGCCGGGAGAGATGCTGGAAGAAACTTCTTAAATGAC
CGCGTCTGGCTGGCCGTGGAGCCTTTCTGGGTTGGGGAGAGGAAAGGAAAGTGGAAAAAACCTGAGAACTTCCTGATCTCTCTCGCTGTG
AGACATGTCTGAGACTCCTGCTCAGTGTAGCATTAAGCAGGAACGAATTTCATATACACCTCCAGAGAGCCCAGTGCCGAGTTACGCTTC
CTCGACGCCACTTCATGTTCCAGTGCCTCGAGCGCTCAGGATGGAGGAAGACTCGATCCGCCTGCCTGCGCACCTGCGGCTATTGAGTGG
CCAGACTTCCCCAACAAATGCCAAATTGGAGAAACTGGACTCTCAGCAGGTGTTGCAGCTCTGCCTCCGATATCAAGATCACCTGCATCA
GTGTGCAGAGGCCGTTGCTTTTGACCAGAATGCTTTGGTTAAACGAATCAAAGAGATGGATCTGTCTGTAGAAACTCTGTTCAGCTTCAT
GCAGGAGCGCCAGAAAAGATACGCCAAGTATGCCGAGCAGATCCAGAAAGTGAACGAGATGTCCGCCATCCTCCGCCGCATACAGATGGG
CATCGACCAGACTGTGCCCCTGCTGGACAGGCTCAACAGCATGCTGCCCGAGGGCGAGCGGCTGGAGCCCTTCAGCATGAAGCCCGACCG
CGAGCTCAGGCTGTAGCTGCTGCCCGGCCTGCCTGGGGCTGGGAGCCCCAGACACCGACACCCTGAGGACGTGTGGAGCTAAGGTCATAT
CATCTGACCAGGTCTGGAGGCTGGCGGGAGGCTCCCTGAAAGTGGGTGCGAAGGAGTCCGGCTGGCATGAAAATCTGACTTTGCCCAGCT
CTTTTCCTTGATGCAGTTTCCCGGTGTGGAAGGAACCTAACCAGTTCTCGGTGATAACTGAAGCTGGAACGTGTGAATTATTAGGAATTC
TTTGAAGAACTCTGCATTGAGAATTATTTTTATTTAGTTTTTTTTTTTTTTTAATTGAGAGTATATAGTCCAGTCCAGGTACCGGAATAA
AAATATGGAGACAAGGGGAAAATATTTTACGAAGCTCTGTGTTCTCAACGCCCTCATGAACTTTTCAGTAGGCTGTCTGGTTTATGTGTG
GTCAACTTGAAAAACTAATTGAATCTAGGTCTCTGTATTGTTCCTGTTTCTACCCTGACTGTTTCCGTCACACCAAGCCCTTATCTGGGG
CGCGTCTTCCTGCCCAGGTGGAACACTGGCATTTTGTTGACTGTCAGGTTAGGTGTCCCTTAGTCGTCATCAGAAGCTGAAGCCTTCCTT
TCCACACCCTCATCAGATTCATCTCCACTGATAACCGGTTTCCTTGATGCAGACATAGTTTAGCTTTCTTTGACTGCAGAGATGTCTCAT
TCCACAGACATTTCTTGAACCCATTTGATGTGTCCAATATTGTGCCAGGGATACAAATATGGCCGTATAGCCTCAGGCCTTCATTTCTGA
AAAGAAAAAAGCTCAAAAAGCTGCTGAATTTCTCTGGGAGTTTAGGAAAGGAAGTTATTTGAGTAACAACAAAAGTGCTTAGTGTCGTAC
TTTACACATCATAGGTGTTCTAATGGAAGCAAGGACTGGAGAAGCAAAGAGTGGAATGTGAGGAGCAGACCTAGGCAGACACCTTGAGAC
TAAAAGTCAGAGCTGAAGGGAGTCGCTGGGGCCAGGACGGCATGCAGGCCTGTACCCTGTTCCCTAAGTTCCTGCAAGCGTCGGGAGGTG

>27726_27726_2_ETV6-LOH12CR1_ETV6_chr12_11905513_ENST00000396373_LOH12CR1_chr12_12588561_ENST00000314565_length(amino acids)=237AA_BP=1
MDYILSIKKKKKLNKNNSQCRVLQRIPNNSHVPASVITENWLGSFHTGKLHQGKELGKVRFSCQPDSFAPTFREPPASLQTWSDDMTLAP
HVLRVSVSGAPSPRQAGQQLQPELAVGLHAEGLQPLALGQHAVEPVQQGHSLVDAHLYAAEDGGHLVHFLDLLGILGVSFLALLHEAEQS

--------------------------------------------------------------
>27726_27726_3_ETV6-LOH12CR1_ETV6_chr12_11905513_ENST00000396373_LOH12CR1_chr12_12588561_ENST00000542728_length(transcript)=833nt_BP=437nt
GCGTCCCGGGTCCCCGCGCCGCGCCGCGACCTGCAGACCCCGCCGCCGCGCTCGGGCCCGTCTCCCACGCCCCCGCCGCCCCGCGCGCCC
AACTCCGCCGGCCGCCCCGCCCCGCCCCGCGCGCTCCAGACCCCCGGGGCGGCTGCCGGGAGAGATGCTGGAAGAAACTTCTTAAATGAC
CGCGTCTGGCTGGCCGTGGAGCCTTTCTGGGTTGGGGAGAGGAAAGGAAAGTGGAAAAAACCTGAGAACTTCCTGATCTCTCTCGCTGTG
AGACATGTCTGAGACTCCTGCTCAGTGTAGCATTAAGCAGGAACGAATTTCATATACACCTCCAGAGAGCCCAGTGCCGAGTTACGCTTC
CTCGACGCCACTTCATGTTCCAGTGCCTCGAGCGCTCAGGATGGAGGAAGACTCGATCCGCCTGCCTGCGCACCTGCGGCTATTGAGTGG
CCAGACTTCCCCAACAAATGCCAAATTGGAGAAACTGGACTCTCAGCAGGTGTTGCAGCTCTGCCTCCGATATCAAGATCACCTGCATCA
GTGTGCAGAGGCCGTTGCTTTTGACCAGAATGCTTTGGTTAAACGAATCAAAGAGATGGATCTGTCTGTAGAAACTCTGTTCAGCTTCAT
GCAGGAGCGCCAGAAAAGATACGCCAAGTATGCCGAGCAGATCCAGAAAGTGAACGAGATGTCCGCCATCCTCCGCCGCATACAGATGGG
CATCGACCAGACTGTGCCCCTGCTGGACAGGCTCAACAGCATGCTGCCCGAGGGCGAGCGGCTGGAGCCCTTCAGCATGAAGCCCGACCG

>27726_27726_3_ETV6-LOH12CR1_ETV6_chr12_11905513_ENST00000396373_LOH12CR1_chr12_12588561_ENST00000542728_length(amino acids)=183AA_BP=0
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLLSGQTSPTNAKLEKLDSQQVLQLCLRYQDHLHQC
AEAVAFDQNALVKRIKEMDLSVETLFSFMQERQKRYAKYAEQIQKVNEMSAILRRIQMGIDQTVPLLDRLNSMLPEGERLEPFSMKPDRE

--------------------------------------------------------------
>27726_27726_4_ETV6-LOH12CR1_ETV6_chr12_11905513_ENST00000396373_LOH12CR1_chr12_12588562_ENST00000298571_length(transcript)=894nt_BP=437nt
GCGTCCCGGGTCCCCGCGCCGCGCCGCGACCTGCAGACCCCGCCGCCGCGCTCGGGCCCGTCTCCCACGCCCCCGCCGCCCCGCGCGCCC
AACTCCGCCGGCCGCCCCGCCCCGCCCCGCGCGCTCCAGACCCCCGGGGCGGCTGCCGGGAGAGATGCTGGAAGAAACTTCTTAAATGAC
CGCGTCTGGCTGGCCGTGGAGCCTTTCTGGGTTGGGGAGAGGAAAGGAAAGTGGAAAAAACCTGAGAACTTCCTGATCTCTCTCGCTGTG
AGACATGTCTGAGACTCCTGCTCAGTGTAGCATTAAGCAGGAACGAATTTCATATACACCTCCAGAGAGCCCAGTGCCGAGTTACGCTTC
CTCGACGCCACTTCATGTTCCAGTGCCTCGAGCGCTCAGGATGGAGGAAGACTCGATCCGCCTGCCTGCGCACCTGCGGCTATTGAGTGG
CCAGACTTCCCCAACAAATGCCAAATTGGAGAAACTGGACTCTCAGCAGGTGTTGCAGCTCTGCCTCCGATATCAAGATCACCTGCATCA
GTGTGCAGAGGCCGTTGCTTTTGACCAGAATGCTTTGGTTAAACGAATCAAAGAGATGGATCTGTCTGTAGAAACTCTGTTCAGCTTCAT
GCAGGAGCGCCAGAAAAGATACGCCAAGTATGCCGAGCAGATCCAGAAAGTGAACGAGATGTCCGCCATCCTCCGCCGCATACAGATGGG
CATCGACCAGACTGTGCCCCTGCTGGACAGGCTCAACAGCATGCTGCCCGAGGGCGAGCGGCTGGAGCCCTTCAGCATGAAGCCCGACCG

>27726_27726_4_ETV6-LOH12CR1_ETV6_chr12_11905513_ENST00000396373_LOH12CR1_chr12_12588562_ENST00000298571_length(amino acids)=183AA_BP=0
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLLSGQTSPTNAKLEKLDSQQVLQLCLRYQDHLHQC
AEAVAFDQNALVKRIKEMDLSVETLFSFMQERQKRYAKYAEQIQKVNEMSAILRRIQMGIDQTVPLLDRLNSMLPEGERLEPFSMKPDRE

--------------------------------------------------------------
>27726_27726_5_ETV6-LOH12CR1_ETV6_chr12_11905513_ENST00000396373_LOH12CR1_chr12_12588562_ENST00000314565_length(transcript)=1956nt_BP=437nt
GCGTCCCGGGTCCCCGCGCCGCGCCGCGACCTGCAGACCCCGCCGCCGCGCTCGGGCCCGTCTCCCACGCCCCCGCCGCCCCGCGCGCCC
AACTCCGCCGGCCGCCCCGCCCCGCCCCGCGCGCTCCAGACCCCCGGGGCGGCTGCCGGGAGAGATGCTGGAAGAAACTTCTTAAATGAC
CGCGTCTGGCTGGCCGTGGAGCCTTTCTGGGTTGGGGAGAGGAAAGGAAAGTGGAAAAAACCTGAGAACTTCCTGATCTCTCTCGCTGTG
AGACATGTCTGAGACTCCTGCTCAGTGTAGCATTAAGCAGGAACGAATTTCATATACACCTCCAGAGAGCCCAGTGCCGAGTTACGCTTC
CTCGACGCCACTTCATGTTCCAGTGCCTCGAGCGCTCAGGATGGAGGAAGACTCGATCCGCCTGCCTGCGCACCTGCGGCTATTGAGTGG
CCAGACTTCCCCAACAAATGCCAAATTGGAGAAACTGGACTCTCAGCAGGTGTTGCAGCTCTGCCTCCGATATCAAGATCACCTGCATCA
GTGTGCAGAGGCCGTTGCTTTTGACCAGAATGCTTTGGTTAAACGAATCAAAGAGATGGATCTGTCTGTAGAAACTCTGTTCAGCTTCAT
GCAGGAGCGCCAGAAAAGATACGCCAAGTATGCCGAGCAGATCCAGAAAGTGAACGAGATGTCCGCCATCCTCCGCCGCATACAGATGGG
CATCGACCAGACTGTGCCCCTGCTGGACAGGCTCAACAGCATGCTGCCCGAGGGCGAGCGGCTGGAGCCCTTCAGCATGAAGCCCGACCG
CGAGCTCAGGCTGTAGCTGCTGCCCGGCCTGCCTGGGGCTGGGAGCCCCAGACACCGACACCCTGAGGACGTGTGGAGCTAAGGTCATAT
CATCTGACCAGGTCTGGAGGCTGGCGGGAGGCTCCCTGAAAGTGGGTGCGAAGGAGTCCGGCTGGCATGAAAATCTGACTTTGCCCAGCT
CTTTTCCTTGATGCAGTTTCCCGGTGTGGAAGGAACCTAACCAGTTCTCGGTGATAACTGAAGCTGGAACGTGTGAATTATTAGGAATTC
TTTGAAGAACTCTGCATTGAGAATTATTTTTATTTAGTTTTTTTTTTTTTTTAATTGAGAGTATATAGTCCAGTCCAGGTACCGGAATAA
AAATATGGAGACAAGGGGAAAATATTTTACGAAGCTCTGTGTTCTCAACGCCCTCATGAACTTTTCAGTAGGCTGTCTGGTTTATGTGTG
GTCAACTTGAAAAACTAATTGAATCTAGGTCTCTGTATTGTTCCTGTTTCTACCCTGACTGTTTCCGTCACACCAAGCCCTTATCTGGGG
CGCGTCTTCCTGCCCAGGTGGAACACTGGCATTTTGTTGACTGTCAGGTTAGGTGTCCCTTAGTCGTCATCAGAAGCTGAAGCCTTCCTT
TCCACACCCTCATCAGATTCATCTCCACTGATAACCGGTTTCCTTGATGCAGACATAGTTTAGCTTTCTTTGACTGCAGAGATGTCTCAT
TCCACAGACATTTCTTGAACCCATTTGATGTGTCCAATATTGTGCCAGGGATACAAATATGGCCGTATAGCCTCAGGCCTTCATTTCTGA
AAAGAAAAAAGCTCAAAAAGCTGCTGAATTTCTCTGGGAGTTTAGGAAAGGAAGTTATTTGAGTAACAACAAAAGTGCTTAGTGTCGTAC
TTTACACATCATAGGTGTTCTAATGGAAGCAAGGACTGGAGAAGCAAAGAGTGGAATGTGAGGAGCAGACCTAGGCAGACACCTTGAGAC
TAAAAGTCAGAGCTGAAGGGAGTCGCTGGGGCCAGGACGGCATGCAGGCCTGTACCCTGTTCCCTAAGTTCCTGCAAGCGTCGGGAGGTG

>27726_27726_5_ETV6-LOH12CR1_ETV6_chr12_11905513_ENST00000396373_LOH12CR1_chr12_12588562_ENST00000314565_length(amino acids)=237AA_BP=1
MDYILSIKKKKKLNKNNSQCRVLQRIPNNSHVPASVITENWLGSFHTGKLHQGKELGKVRFSCQPDSFAPTFREPPASLQTWSDDMTLAP
HVLRVSVSGAPSPRQAGQQLQPELAVGLHAEGLQPLALGQHAVEPVQQGHSLVDAHLYAAEDGGHLVHFLDLLGILGVSFLALLHEAEQS

--------------------------------------------------------------
>27726_27726_6_ETV6-LOH12CR1_ETV6_chr12_11905513_ENST00000396373_LOH12CR1_chr12_12588562_ENST00000542728_length(transcript)=833nt_BP=437nt
GCGTCCCGGGTCCCCGCGCCGCGCCGCGACCTGCAGACCCCGCCGCCGCGCTCGGGCCCGTCTCCCACGCCCCCGCCGCCCCGCGCGCCC
AACTCCGCCGGCCGCCCCGCCCCGCCCCGCGCGCTCCAGACCCCCGGGGCGGCTGCCGGGAGAGATGCTGGAAGAAACTTCTTAAATGAC
CGCGTCTGGCTGGCCGTGGAGCCTTTCTGGGTTGGGGAGAGGAAAGGAAAGTGGAAAAAACCTGAGAACTTCCTGATCTCTCTCGCTGTG
AGACATGTCTGAGACTCCTGCTCAGTGTAGCATTAAGCAGGAACGAATTTCATATACACCTCCAGAGAGCCCAGTGCCGAGTTACGCTTC
CTCGACGCCACTTCATGTTCCAGTGCCTCGAGCGCTCAGGATGGAGGAAGACTCGATCCGCCTGCCTGCGCACCTGCGGCTATTGAGTGG
CCAGACTTCCCCAACAAATGCCAAATTGGAGAAACTGGACTCTCAGCAGGTGTTGCAGCTCTGCCTCCGATATCAAGATCACCTGCATCA
GTGTGCAGAGGCCGTTGCTTTTGACCAGAATGCTTTGGTTAAACGAATCAAAGAGATGGATCTGTCTGTAGAAACTCTGTTCAGCTTCAT
GCAGGAGCGCCAGAAAAGATACGCCAAGTATGCCGAGCAGATCCAGAAAGTGAACGAGATGTCCGCCATCCTCCGCCGCATACAGATGGG
CATCGACCAGACTGTGCCCCTGCTGGACAGGCTCAACAGCATGCTGCCCGAGGGCGAGCGGCTGGAGCCCTTCAGCATGAAGCCCGACCG

>27726_27726_6_ETV6-LOH12CR1_ETV6_chr12_11905513_ENST00000396373_LOH12CR1_chr12_12588562_ENST00000542728_length(amino acids)=183AA_BP=0
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLLSGQTSPTNAKLEKLDSQQVLQLCLRYQDHLHQC
AEAVAFDQNALVKRIKEMDLSVETLFSFMQERQKRYAKYAEQIQKVNEMSAILRRIQMGIDQTVPLLDRLNSMLPEGERLEPFSMKPDRE

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for ETV6-LOH12CR1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for ETV6-LOH12CR1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for ETV6-LOH12CR1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource