|
||||||
|
 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:EVA1C-HUNK (FusionGDB2 ID:27759) |
Fusion Gene Summary for EVA1C-HUNK |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: EVA1C-HUNK | Fusion gene ID: 27759 | Hgene | Tgene | Gene symbol | EVA1C | HUNK | Gene ID | 59271 | 30811 |
| Gene name | eva-1 homolog C | hormonally up-regulated Neu-associated kinase | |
| Synonyms | B18|B19|C21orf63|C21orf64|FAM176C|PRED34|SUE21 | - | |
| Cytomap | 21q22.11 | 21q22.11 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein eva-1 homolog Cfamily with sequence similarity 176, member Cprotein FAM176C | hormonally up-regulated neu tumor-associated kinaseB19hormonally upregulated Neu-associated kinasehormonally upregulated neu tumor-associated kinaseserine/threonine protein kinase MAK-V | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | P58658 | P57058 | |
| Ensembl transtripts involved in fusion gene | ENST00000300255, ENST00000382699, ENST00000401402, ENST00000485488, | ENST00000465574, ENST00000270112, | |
| Fusion gene scores | * DoF score | 12 X 7 X 8=672 | 9 X 9 X 5=405 |
| # samples | 13 | 9 | |
| ** MAII score | log2(13/672*10)=-2.36994960975031 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/405*10)=-2.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: EVA1C [Title/Abstract] AND HUNK [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | EVA1C(33840156)-HUNK(33318348), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene breakpoints across EVA1C (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
| Fusion gene breakpoints across HUNK (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | BRCA | TCGA-E9-A22H-01A | EVA1C | chr21 | 33840156 | + | HUNK | chr21 | 33318348 | + |
Top |
Fusion Gene ORF analysis for EVA1C-HUNK |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000300255 | ENST00000465574 | EVA1C | chr21 | 33840156 | + | HUNK | chr21 | 33318348 | + |
| 5CDS-intron | ENST00000382699 | ENST00000465574 | EVA1C | chr21 | 33840156 | + | HUNK | chr21 | 33318348 | + |
| 5CDS-intron | ENST00000401402 | ENST00000465574 | EVA1C | chr21 | 33840156 | + | HUNK | chr21 | 33318348 | + |
| In-frame | ENST00000300255 | ENST00000270112 | EVA1C | chr21 | 33840156 | + | HUNK | chr21 | 33318348 | + |
| In-frame | ENST00000382699 | ENST00000270112 | EVA1C | chr21 | 33840156 | + | HUNK | chr21 | 33318348 | + |
| In-frame | ENST00000401402 | ENST00000270112 | EVA1C | chr21 | 33840156 | + | HUNK | chr21 | 33318348 | + |
| intron-3CDS | ENST00000485488 | ENST00000270112 | EVA1C | chr21 | 33840156 | + | HUNK | chr21 | 33318348 | + |
| intron-intron | ENST00000485488 | ENST00000465574 | EVA1C | chr21 | 33840156 | + | HUNK | chr21 | 33318348 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000300255 | EVA1C | chr21 | 33840156 | + | ENST00000270112 | HUNK | chr21 | 33318348 | + | 7522 | 1107 | 443 | 2641 | 732 |
| ENST00000401402 | EVA1C | chr21 | 33840156 | + | ENST00000270112 | HUNK | chr21 | 33318348 | + | 7218 | 803 | 139 | 2337 | 732 |
| ENST00000382699 | EVA1C | chr21 | 33840156 | + | ENST00000270112 | HUNK | chr21 | 33318348 | + | 7201 | 786 | 122 | 2320 | 732 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000300255 | ENST00000270112 | EVA1C | chr21 | 33840156 | + | HUNK | chr21 | 33318348 | + | 0.002447563 | 0.99755245 |
| ENST00000401402 | ENST00000270112 | EVA1C | chr21 | 33840156 | + | HUNK | chr21 | 33318348 | + | 0.002479026 | 0.997521 |
| ENST00000382699 | ENST00000270112 | EVA1C | chr21 | 33840156 | + | HUNK | chr21 | 33318348 | + | 0.002466389 | 0.99753356 |
Top |
Fusion Genomic Features for EVA1C-HUNK |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| EVA1C | chr21 | 33840156 | + | HUNK | chr21 | 33318347 | + | 7.73E-07 | 0.9999993 |
| EVA1C | chr21 | 33840156 | + | HUNK | chr21 | 33318347 | + | 7.73E-07 | 0.9999993 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
 |
Top |
Fusion Protein Features for EVA1C-HUNK |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr21:33840156/chr21:33318348) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| EVA1C | HUNK |
| FUNCTION: Binds heparin. {ECO:0000269|PubMed:19470522}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | EVA1C | chr21:33840156 | chr21:33318348 | ENST00000300255 | + | 4 | 8 | 67_159 | 211 | 442.0 | Domain | SUEL-type lectin 1 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | EVA1C | chr21:33840156 | chr21:33318348 | ENST00000300255 | + | 4 | 8 | 373_379 | 211 | 442.0 | Compositional bias | Note=Poly-Glu |
| Hgene | EVA1C | chr21:33840156 | chr21:33318348 | ENST00000300255 | + | 4 | 8 | 168_260 | 211 | 442.0 | Domain | SUEL-type lectin 2 |
| Hgene | EVA1C | chr21:33840156 | chr21:33318348 | ENST00000300255 | + | 4 | 8 | 344_441 | 211 | 442.0 | Topological domain | Cytoplasmic |
| Hgene | EVA1C | chr21:33840156 | chr21:33318348 | ENST00000300255 | + | 4 | 8 | 49_322 | 211 | 442.0 | Topological domain | Extracellular |
| Hgene | EVA1C | chr21:33840156 | chr21:33318348 | ENST00000300255 | + | 4 | 8 | 323_343 | 211 | 442.0 | Transmembrane | Helical |
| Tgene | HUNK | chr21:33840156 | chr21:33318348 | ENST00000270112 | 2 | 11 | 62_320 | 203 | 715.0 | Domain | Protein kinase | |
| Tgene | HUNK | chr21:33840156 | chr21:33318348 | ENST00000270112 | 2 | 11 | 68_76 | 203 | 715.0 | Nucleotide binding | ATP |
Top |
Fusion Gene Sequence for EVA1C-HUNK |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >27759_27759_1_EVA1C-HUNK_EVA1C_chr21_33840156_ENST00000300255_HUNK_chr21_33318348_ENST00000270112_length(transcript)=7522nt_BP=1107nt GGGCGAGGCTGGCACCCGGCCAGCGCGGGCAGGGCCACGGGTGCCCGGCTGTTTCCCGGGTGTGGAAGGCGCTCAAGGTGCGCGGCCCGG GGCGCGCTACTGGGGGCGCCCTCCGCGGTGGGCAGCGCGCCAGGGATCGGCCTGGGCAGCCGCGGGGCGCGCGAAGGCTGCGCTTTCCCT ACGGCCCCCCTCGCTTCCTCCGGCACGGCGGCAACGGAGATTTCCTCTCGGGGAAACTACGCGGATCCTTTTCGGGGATCCTCGCCCCGC CCCAGTTCTCCGCCCCCTCCCCTTTGCTGGGGCGCCTGGGCTGGCCCGCGCAGGGGAGGAGGCTCTGGCAGCCTGGGCAGGGAGGCGGCG GGGGGCCGCGGAGCCGCTGGCCATCGATTCTCCCCGCCATGTGACGCCGTCCTTAGCCCTGCGACCCCCAGCGCGTCCCGGGCCTGCGCC TCCGCCCCGCCGCGCAGCGCACGATGCTTCTGCCGGGACGCGCACGCCAACCGCCGACGCCCCAGCCCGTGCAGCATCCCGGCCTCCGCC GGCAGGTAGAGCCGCCGGGGCAGCTCCTGCGCCTCTTCTACTGCACTGTCCTGGTCTGCTCCAAAGAGATCTCAGCGCTCACCGACTTCT CTGGTTACCTAACCAAACTCCTGCAAAACCACACCACCTATGCCTGTGATGGGGACTATTTGAATCTACAGTGCCCTCGGCATTCTACGA TAAGTGTCCAATCGGCATTTTATGGGCAAGATTACCAAATGTGTAGTTCCCAGAAGCCTGCCTCCCAGAGGGAAGACAGCTTAACCTGTG TGGCAGCCACCACCTTCCAGAAGGTGCTGGACGAATGCCAGAACCAGCGGGCCTGCCACCTCCTGGTCAATAGCCGTGTTTTTGGACCTG ACCTTTGTCCAGGAAGCAGTAAATACCTCCTGGTCTCCTTTAAATGCCAACCTAATGAATTAAAAAACAAAACCGTGTGTGAAGACCAGG AGCTGAAACTGCACTGCCATGAATCCAAGTTCCTCAACATCTACTCTGCGACCTACGGCAGGAGGACCCAGGAAAGGGACATCTGCTCCT CCAAGGCAGAGCGGCTCCCCCCTTTCGACTTTGGTTTGAGCAACTGCGCAGGGATCCTGGGTTACTCGGATCCGTTCAGCACACAGTGTG GCAGCCCTGCCTACGCTGCACCTGAACTGCTCGCCAGGAAGAAATACGGCCCCAAAATCGATGTCTGGTCCATAGGTGTGAACATGTATG CCATGTTGACCGGGACGCTGCCTTTCACGGTGGAGCCTTTCAGCCTGAGGGCTTTGTACCAGAAGATGGTAGACAAAGAAATGAACCCCC TCCCCACTCAGCTCTCCACAGGTGCCATCAGTTTCCTGCGCTCTCTCCTGGAACCGGATCCTGTGAAGAGGCCAAATATTCAGCAGGCAC TGGCGAATCGCTGGCTTAATGAGAATTACACGGGCAAAGTGCCCTGTAATGTCACCTATCCCAACAGGATTTCTCTGGAAGATCTGAGCC CGAGCGTCGTGCTGCACATGACCGAGAAGCTGGGTTACAAGAACAGCGACGTGATCAACACTGTGCTCTCCAACCGCGCCTGCCACATCC TGGCCATCTACTTCCTCTTAAACAAGAAACTGGAGCGCTATTTGTCAGGGAAATCTGACATCCAGGACAGCCTCTGCTACAAGACCCGGC TCTACCAGATAGAAAAGTACAGGGCCCCCAAGGAGTCCTATGAGGCCTCTCTGGACACCTGGACACGAGATCTTGAATTCCATGCCGTGC AGGATAAAAAGCCCAAAGAACAAGAAAAAAGAGGGGATTTTCTTCATCGACCATTCTCCAAGAAGTTGGACAAGAACCTGCCCTCGCACA AACAGCCCTCAGGCTCGCTTATGACACAGATTCAGAACACCAAAGCCCTCCTGAAGGACCGGAAGGCCTCCAAGTCCAGCTTCCCCGACA AAGATTCCTTTGGCTGCCGCAATATTTTCCGCAAAACCTCAGATTCCAATTGTGTGGCTTCTTCTTCCATGGAGTTCATCCCCGTGCCAC CGCCCAGGACCCCGAGGATTGTGAAGAAACCGGAGCCCCATCAGCCAGGGCCCGGAAGCACTGGCATCCCCCACAAGGAAGACCCCCTGA TGCTGGACATGGTGCGCTCCTTCGAGTCTGTGGATCGCGACGACCACGTAGAAGTGCTGTCTCCCTCTCATCACTACAGGATTCTGAACT CCCCGGTCAGCTTGGCTCGCAGAAATTCCAGCGAGAGGACGCTGTCCCCGGGTCTGCCATCCGGAAGCATGTCGCCTCTCCATACTCCTT TGCATCCAACTCTGGTCTCTTTTGCTCACGAAGATAAGAACAGCCCCCCAAAAGAGGAGGGCCTGTGTTGCCCACCTCCGGTTCCCAGCA ATGGCCCCATGCAGCCTCTGGGGAGCCCCAATTGTGTGAAAAGCCGAGGCCGGTTCCCTATGATGGGCATCGGACAGATGTTAAGGAAGC GCCATCAGAGTCTGCAGCCATCTGCAGATAGGCCCCTGGAGGCCAGCCTGCCCCCACTGCAGCCCCTAGCCCCTGTGAACCTTGCCTTTG ACATGGCCGATGGGGTCAAGACCCAGTGCTAACTTGGGCCAGCGGGGTTTGGGGTATCTCTAGAAAACAGCAACTGAACAGAGCTCCACA CATCTGTCAGGGTGTGAGCACTCCAAGGCCTCGCGTGGAGCATCCTTAGTCCCACCTGTAGCTGAATCCACAGACCCAAAGCCTGCACAA CCCAACCTCGCTTAGGGACCCCCAGAGATGCTGGAATCGCTAGGAGGGTTGGCTCCAGGGGCAGCCAATTCCTATCATTCAGATCTTCCT TCCTCCCAAGTACTCACCAACCCCTTCCACTTCCCACTTCCCCCAGGCTTGGGGGGAAAACAGGGCATGAGCCTTCTGGGGCACTCAGAT TATGGACTGTTACCAGATCTTTCTTCACGCTGTGCTACATGTGTGCCTCTCACAGCAGTTGGCCACAGTTACAGGGAGAGAACAATATCA CAGTCATTCATCCAGGCCACGTTTCCTCTGCGGAGTGTAGCAGCCCTGCCTTTCATAGCAGGGATTACCTGAAGGCCAGCAGGAGCCGGG GGCAGGCCCAGGATCCTCAGAGGAAGATGGAGAGGAGCTTCGGACCAAGATCAAACCAAACAGTGGGGACCCCAACAGAAGAGAAAGACT GAAGGAGACACTCATTTCCCAAGCAAGATTTTGATAGATTTTTGTTGTTGTTGTTGTTGAAACATGCTAATGATTGAATTATCTTTTCCA AAGATTTTTTTTAAATGTGATGTCGGTAAATTGAAATAACATAATTTTTTAAAACTTGGATGGAGAGATGAGAAGCAATTCCACCAAACT CATGTTTTCACAGGAGGGTTCAGTGTGGAGAGCAAAAAAGCTGACTGTGGTGATTTGCTGAGTGCTGTGGCCCACAGGCAGGGCAAGTCT CGGTGGCCCTGTGTTCATCCTGTTGTTTAAGGCATAGCCCTGATCCTTCTGGAAGGCATAGAACACGGTTACAGCTGGTTCTGTAGAAAG AGGGAAAAGATGATTGTGACAATTCAGAGCATAACTCAGATGGCGAGAAGGCAGCATTATCTCTGTGCGATGCTGATTTCAAGCTGCCCA CAGAACTGGTGCGGCTCAGAGCTCGGCGAGTTTGCTGGGAGCTGGGAGCAGGCTTGCCTGGCAGAGAACCTGTTCAGATACAGGCCAGTT TCTTCTTCGAGGAAAGCCAAGCTCCTCAAACAGGGTTCAGTCCACGTTGTGTTTTCACACCTTTCTCCAAGGATCGAACCAAAGATGTGT CTCCAGTATTGTGTCTGTGCCCCTGTGTGTGTTTTGTGGACAGCCGTGTTGTCTGACTGTATCCAGCTGGCACTTGACAGGGTGCAGTCA TTGGTGAGAAGAATCAGAAAAAGAAGACCCATCAGCACAGGTTGGATAGGGGTTAGTGTAGGAGACCAGTTACAGAATGGCCTGGAGTCT TCAACTTTTGACCGGTGCAGGTGTGACCAGAGACCACCTCTGTGGCCACCTCAGATAGTCATCTCAGTCCAAGGATCCCAAAACACAAAT CTAGAATTGCAAAGCCAGCCTTTATTTCCCTGGCAGGCAGCCTTGCCAGAAGGCAGAGAGGCAGTTCTGAATCATTCTCTCATTCACCAG TGGTGACATCCTTCAGTCCCTCACATCTCTGACAGAGCGGGACAGAATGGATATTTGGCTGACCTTGGTGAGACCTGGAGCTGCCTGTTT CTTCCCTAGGGGATCACCACGGCTCTAGGGCATTCTAGGATGAGGTCAGACCCCTTGGCCATTGGTGTTATTTTTTGTATAGCTTCAGAC TGGGTTCCAGAACTTACCATTGAAAACAGAGCTTTTAGGCCAGGTGTGGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCGAGGC AGGTGGATCGCTTGAGCTCAGGAGTTCGAGAGCAGCCTGGGCAACATGGTGAAAGCCCGTCTCTACCGAAAAATACAAAAAAAAATAGCT GGGTGTGGTGGTACGTGCCTGTAGTCCCAGCTACTTCGGGGACTGAGGTGGGAGGATCACTTGAACCTAGGAGGTCGAGGCTGCAGTGAG CCAAGATCATGCTACTGCACTCCAGCTTAGGTGGCAAAGTGAGACCCTGTCTCCAAAAAAAGAAAATAGAGCTTTATAAGCAGAGAGAAG AAAATAATCATCTAAGACCATCTCTCCATTCGACATGAAGTGTACCTTTTCTAAAGACGGTTTCCAGCTGCAACGGCTCCACTTTGCAGG CTTGCAGGGTGTATACCTGCGCATTGGGAACTTGCTGGAACCCCTGATGCATTTTCCTTGAGAGCAGGGGTACTTCCGCCTTGCCGTTAG CTTGTGGAGAACGTGCTTCTTATTCCTGGCAGGCTTCAAGAACAGCTGCACATGTGCCGCTAACTGACCGCGTTGCCATTGGCGACCTGG ACTCTGAACTCAGGTTTATTCTAAACCCAGTGAGAGGTGAGGGGGAGTGATGAAAGGGGATCAGCTGTATTTGTGTGTGTGTGTGTGTGT GAGCACCTGACAAATCTATGAAACCGAGTGAAAGGAGAAATGTTAGATTCTTTATTATTTTATTATATTTATATGGAAAGCTCGACTCTC CCTTTGGTAAGTCCGAAGCATGTTGTCTGTTCGACCGTGACTGTCTTCCTCAGTCTGTGCCTGTGATTCCAGTCACCCTGTAGTTACTGA CAGAAATTGACTGGACTGTCATTGTGTGAAGTCTAGGAGGAAATGTCCATTTTAATTGTATGATTTGGTCATAAGTAAGGACTATATTTA TGTCACCATTATTAGATATATGTACTTTTGTAATGACTGTGAAATACACTTTTCCCTCACTACGACTGCTTCTTTATTTGCTGATAAATC TTAAAACAACTAAGTACGTTGCAAATAATAGTACAGGTACCATCTTTTATGTGAAGTTCTTTTTCTTTTTTTGAGACAGGGTCTTGCTCT GTCACCCAGGCTGGAGTGCAGTGGCACAATCACAGTTCACTGCAGCCTCAACCTCTCCAGATTCAAGTGATCCTCCCATCTCAGCCTCCC AAGTAGCTGGGACTACAGTTGTGCACCACAATGCCTAGCTAATTTTTTTTGTATTTTGTAGAAATGGGGTTTCGCCATGTTGCTCAGGCT GATCTCAAACTCCTGGGCTCCAACGATCTGCCCACCTTGGCCTCCCAAAGTGCTGAGATTACAGGCGTGAGCCACTGTGCCTGGCCTTAT GTAAAGCTCTTGACCTAGCATCTGACTGGAAACAAGCGGGAATTGCATTGGGGGGCATTTTCTGGGCCAGTTTCCCTGCCTTATTTTACC TGCAATAGGTGTGCCTACAAAAGTCTTTCTGACATACACACTGCAGGTGGCAGTTCAAGAAGAATCAACCTTTTTCATTTGGGGATATTA GGATCTTCCTTGGAGACTCTGAAAATGGCACACAAAGAATGGCAGTTATGAACGTGACTTCTAGATTTTGTCCTTGTAGGAGGCCTTGGT CATGGATAGGGGAAGAGGGATGATGGGATGGAATGGGAGGGTGGGATCTAGATGACCTCTTGAAATTGTCCCAGTTACTGCTTCCTTCAT AACTGTTCACAAAACGTTTTTCATATATACCACCTTGTTTCCCCTGGGAAGTGAGGGGACGAAGCCTTAGAGGGTGACATAGCTAGAAAG TGGAGAAGCTCACTGTTCACTGTGCAAAGCCCCAGTAGTCGGATTCCGGGGAAAAGAACAAGTATCTAGTTTTGATGACAATGTTTTCTT GTAAGAATCCCAACACTTTAGAATAGAAAAGGACCTAAGATTCTCTGGCTCAGCCCCAGCCTTTCTGAAGAAGGGAAAACTAGGGACCCA GATGGTTTAAGGACACCCCAGAGTCCCCAGATGAGCTGGCATTTGAGCTGGTCTGGAGCAGAGTTTCTCCCTCAAAGAACACAGAGAAAT CAGAGAGTGGCTGCCATGGTCAGAGGGGGATGTCAACAACAGATCAAGCCGTCATCACAACAGGTATTTCTGAAGTTCCTGCAGGGACTA GGTCTTGCATTTTTAAGTCCTTTTCAAAACTGTGCAGCTTCCTGAACCTTATGCTGTTTGTCCCATCCACTCTTGAAGCTGGGGAAAGAC AGCTTTCTTTGGGAACTCTGTCTTTCTCAGTTGACTTCCCAAGTAAGCAGCAAACCCCTGGATAGCCTTGTTATCTACTTTAGGTATTAA GAGGCTATTGGGTTTTACTAGATTAAATCAATAAAACATTTCCTATAGAGCCATATCATACACTGAAGCAAATTCAGAAAGAATGCAAAA CTGCTATCTTTTGGGGGAGTCTGGAAGCCTGTTGGTTAGTGTATTTATTTTCTTTGTGGGGTCTTCTGTGAGCTACAGGCACAGTAAGAA TAATTCAGAGCGGTACTGGGAGTTGGTTCAATTTCATGTCATCACTTTTCAATGAAGGGAGTGCATTTCCTGAGTAGTAAATGAGTATAT TATTTGTGGCAGCTTTTCTGTTAAGGGAGCTTTCCAGACATCTGGTTGCAAAGACAAATAGGATATATATTTGTACTTCTTCTCTGTGGA CATGTTTTTGTGACACACAGTTATCTCTAGGAGTTGACGTCTGTGGGCACTAAGGGACTGAGGTTGGGGGAGAAAGCTGAGGAGGCTTTG GAAGAGAAGGTGAGGAGCATTTCAGGATTTGCAGTCCCCCTCCACATGTATCCACATCTGAGCTGGTGGTGTTCCAATAATGAGGCATTT GGGGCAACCAATTTTGGAAGGATAGAATAGCTTTATGTGGAGCAAACTTGAGGATCAATTGGAGTTGAGTGGTTTAAAACTTAAAGATGG >27759_27759_1_EVA1C-HUNK_EVA1C_chr21_33840156_ENST00000300255_HUNK_chr21_33318348_ENST00000270112_length(amino acids)=732AA_BP=221 MRLRPAAQRTMLLPGRARQPPTPQPVQHPGLRRQVEPPGQLLRLFYCTVLVCSKEISALTDFSGYLTKLLQNHTTYACDGDYLNLQCPRH STISVQSAFYGQDYQMCSSQKPASQREDSLTCVAATTFQKVLDECQNQRACHLLVNSRVFGPDLCPGSSKYLLVSFKCQPNELKNKTVCE DQELKLHCHESKFLNIYSATYGRRTQERDICSSKAERLPPFDFGLSNCAGILGYSDPFSTQCGSPAYAAPELLARKKYGPKIDVWSIGVN MYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQLSTGAISFLRSLLEPDPVKRPNIQQALANRWLNENYTGKVPCNVTYPNRISLED LSPSVVLHMTEKLGYKNSDVINTVLSNRACHILAIYFLLNKKLERYLSGKSDIQDSLCYKTRLYQIEKYRAPKESYEASLDTWTRDLEFH AVQDKKPKEQEKRGDFLHRPFSKKLDKNLPSHKQPSGSLMTQIQNTKALLKDRKASKSSFPDKDSFGCRNIFRKTSDSNCVASSSMEFIP VPPPRTPRIVKKPEPHQPGPGSTGIPHKEDPLMLDMVRSFESVDRDDHVEVLSPSHHYRILNSPVSLARRNSSERTLSPGLPSGSMSPLH TPLHPTLVSFAHEDKNSPPKEEGLCCPPPVPSNGPMQPLGSPNCVKSRGRFPMMGIGQMLRKRHQSLQPSADRPLEASLPPLQPLAPVNL -------------------------------------------------------------- >27759_27759_2_EVA1C-HUNK_EVA1C_chr21_33840156_ENST00000382699_HUNK_chr21_33318348_ENST00000270112_length(transcript)=7201nt_BP=786nt AGGGGAGGAGGCTCTGGCAGCCTGGGCAGGGAGGCGGCGGGGGGCCGCGGAGCCGCTGGCCATCGATTCTCCCCGCCATGTGACGCCGTC CTTAGCCCTGCGACCCCCAGCGCGTCCCGGGCCTGCGCCTCCGCCCCGCCGCGCAGCGCACGATGCTTCTGCCGGGACGCGCACGCCAAC CGCCGACGCCCCAGCCCGTGCAGCATCCCGGCCTCCGCCGGCAGGTAGAGCCGCCGGGGCAGCTCCTGCGCCTCTTCTACTGCACTGTCC TGGTCTGCTCCAAAGAGATCTCAGCGCTCACCGACTTCTCTGGTTACCTAACCAAACTCCTGCAAAACCACACCACCTATGCCTGTGATG GGGACTATTTGAATCTACAGTGCCCTCGGCATTCTACGATAAGTGTCCAATCGGCATTTTATGGGCAAGATTACCAAATGTGTAGTTCCC AGAAGCCTGCCTCCCAGAGGGAAGACAGCTTAACCTGTGTGGCAGCCACCACCTTCCAGAAGGTGCTGGACGAATGCCAGAACCAGCGGG CCTGCCACCTCCTGGTCAATAGCCGTGTTTTTGGACCTGACCTTTGTCCAGGAAGCAGTAAATACCTCCTGGTCTCCTTTAAATGCCAAC CTAATGAATTAAAAAACAAAACCGTGTGTGAAGACCAGGAGCTGAAACTGCACTGCCATGAATCCAAGTTCCTCAACATCTACTCTGCGA CCTACGGCAGGAGGACCCAGGAAAGGGACATCTGCTCCTCCAAGGCAGAGCGGCTCCCCCCTTTCGACTTTGGTTTGAGCAACTGCGCAG GGATCCTGGGTTACTCGGATCCGTTCAGCACACAGTGTGGCAGCCCTGCCTACGCTGCACCTGAACTGCTCGCCAGGAAGAAATACGGCC CCAAAATCGATGTCTGGTCCATAGGTGTGAACATGTATGCCATGTTGACCGGGACGCTGCCTTTCACGGTGGAGCCTTTCAGCCTGAGGG CTTTGTACCAGAAGATGGTAGACAAAGAAATGAACCCCCTCCCCACTCAGCTCTCCACAGGTGCCATCAGTTTCCTGCGCTCTCTCCTGG AACCGGATCCTGTGAAGAGGCCAAATATTCAGCAGGCACTGGCGAATCGCTGGCTTAATGAGAATTACACGGGCAAAGTGCCCTGTAATG TCACCTATCCCAACAGGATTTCTCTGGAAGATCTGAGCCCGAGCGTCGTGCTGCACATGACCGAGAAGCTGGGTTACAAGAACAGCGACG TGATCAACACTGTGCTCTCCAACCGCGCCTGCCACATCCTGGCCATCTACTTCCTCTTAAACAAGAAACTGGAGCGCTATTTGTCAGGGA AATCTGACATCCAGGACAGCCTCTGCTACAAGACCCGGCTCTACCAGATAGAAAAGTACAGGGCCCCCAAGGAGTCCTATGAGGCCTCTC TGGACACCTGGACACGAGATCTTGAATTCCATGCCGTGCAGGATAAAAAGCCCAAAGAACAAGAAAAAAGAGGGGATTTTCTTCATCGAC CATTCTCCAAGAAGTTGGACAAGAACCTGCCCTCGCACAAACAGCCCTCAGGCTCGCTTATGACACAGATTCAGAACACCAAAGCCCTCC TGAAGGACCGGAAGGCCTCCAAGTCCAGCTTCCCCGACAAAGATTCCTTTGGCTGCCGCAATATTTTCCGCAAAACCTCAGATTCCAATT GTGTGGCTTCTTCTTCCATGGAGTTCATCCCCGTGCCACCGCCCAGGACCCCGAGGATTGTGAAGAAACCGGAGCCCCATCAGCCAGGGC CCGGAAGCACTGGCATCCCCCACAAGGAAGACCCCCTGATGCTGGACATGGTGCGCTCCTTCGAGTCTGTGGATCGCGACGACCACGTAG AAGTGCTGTCTCCCTCTCATCACTACAGGATTCTGAACTCCCCGGTCAGCTTGGCTCGCAGAAATTCCAGCGAGAGGACGCTGTCCCCGG GTCTGCCATCCGGAAGCATGTCGCCTCTCCATACTCCTTTGCATCCAACTCTGGTCTCTTTTGCTCACGAAGATAAGAACAGCCCCCCAA AAGAGGAGGGCCTGTGTTGCCCACCTCCGGTTCCCAGCAATGGCCCCATGCAGCCTCTGGGGAGCCCCAATTGTGTGAAAAGCCGAGGCC GGTTCCCTATGATGGGCATCGGACAGATGTTAAGGAAGCGCCATCAGAGTCTGCAGCCATCTGCAGATAGGCCCCTGGAGGCCAGCCTGC CCCCACTGCAGCCCCTAGCCCCTGTGAACCTTGCCTTTGACATGGCCGATGGGGTCAAGACCCAGTGCTAACTTGGGCCAGCGGGGTTTG GGGTATCTCTAGAAAACAGCAACTGAACAGAGCTCCACACATCTGTCAGGGTGTGAGCACTCCAAGGCCTCGCGTGGAGCATCCTTAGTC CCACCTGTAGCTGAATCCACAGACCCAAAGCCTGCACAACCCAACCTCGCTTAGGGACCCCCAGAGATGCTGGAATCGCTAGGAGGGTTG GCTCCAGGGGCAGCCAATTCCTATCATTCAGATCTTCCTTCCTCCCAAGTACTCACCAACCCCTTCCACTTCCCACTTCCCCCAGGCTTG GGGGGAAAACAGGGCATGAGCCTTCTGGGGCACTCAGATTATGGACTGTTACCAGATCTTTCTTCACGCTGTGCTACATGTGTGCCTCTC ACAGCAGTTGGCCACAGTTACAGGGAGAGAACAATATCACAGTCATTCATCCAGGCCACGTTTCCTCTGCGGAGTGTAGCAGCCCTGCCT TTCATAGCAGGGATTACCTGAAGGCCAGCAGGAGCCGGGGGCAGGCCCAGGATCCTCAGAGGAAGATGGAGAGGAGCTTCGGACCAAGAT CAAACCAAACAGTGGGGACCCCAACAGAAGAGAAAGACTGAAGGAGACACTCATTTCCCAAGCAAGATTTTGATAGATTTTTGTTGTTGT TGTTGTTGAAACATGCTAATGATTGAATTATCTTTTCCAAAGATTTTTTTTAAATGTGATGTCGGTAAATTGAAATAACATAATTTTTTA AAACTTGGATGGAGAGATGAGAAGCAATTCCACCAAACTCATGTTTTCACAGGAGGGTTCAGTGTGGAGAGCAAAAAAGCTGACTGTGGT GATTTGCTGAGTGCTGTGGCCCACAGGCAGGGCAAGTCTCGGTGGCCCTGTGTTCATCCTGTTGTTTAAGGCATAGCCCTGATCCTTCTG GAAGGCATAGAACACGGTTACAGCTGGTTCTGTAGAAAGAGGGAAAAGATGATTGTGACAATTCAGAGCATAACTCAGATGGCGAGAAGG CAGCATTATCTCTGTGCGATGCTGATTTCAAGCTGCCCACAGAACTGGTGCGGCTCAGAGCTCGGCGAGTTTGCTGGGAGCTGGGAGCAG GCTTGCCTGGCAGAGAACCTGTTCAGATACAGGCCAGTTTCTTCTTCGAGGAAAGCCAAGCTCCTCAAACAGGGTTCAGTCCACGTTGTG TTTTCACACCTTTCTCCAAGGATCGAACCAAAGATGTGTCTCCAGTATTGTGTCTGTGCCCCTGTGTGTGTTTTGTGGACAGCCGTGTTG TCTGACTGTATCCAGCTGGCACTTGACAGGGTGCAGTCATTGGTGAGAAGAATCAGAAAAAGAAGACCCATCAGCACAGGTTGGATAGGG GTTAGTGTAGGAGACCAGTTACAGAATGGCCTGGAGTCTTCAACTTTTGACCGGTGCAGGTGTGACCAGAGACCACCTCTGTGGCCACCT CAGATAGTCATCTCAGTCCAAGGATCCCAAAACACAAATCTAGAATTGCAAAGCCAGCCTTTATTTCCCTGGCAGGCAGCCTTGCCAGAA GGCAGAGAGGCAGTTCTGAATCATTCTCTCATTCACCAGTGGTGACATCCTTCAGTCCCTCACATCTCTGACAGAGCGGGACAGAATGGA TATTTGGCTGACCTTGGTGAGACCTGGAGCTGCCTGTTTCTTCCCTAGGGGATCACCACGGCTCTAGGGCATTCTAGGATGAGGTCAGAC CCCTTGGCCATTGGTGTTATTTTTTGTATAGCTTCAGACTGGGTTCCAGAACTTACCATTGAAAACAGAGCTTTTAGGCCAGGTGTGGTG GCTCACACCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGTGGATCGCTTGAGCTCAGGAGTTCGAGAGCAGCCTGGGCAACATGGTG AAAGCCCGTCTCTACCGAAAAATACAAAAAAAAATAGCTGGGTGTGGTGGTACGTGCCTGTAGTCCCAGCTACTTCGGGGACTGAGGTGG GAGGATCACTTGAACCTAGGAGGTCGAGGCTGCAGTGAGCCAAGATCATGCTACTGCACTCCAGCTTAGGTGGCAAAGTGAGACCCTGTC TCCAAAAAAAGAAAATAGAGCTTTATAAGCAGAGAGAAGAAAATAATCATCTAAGACCATCTCTCCATTCGACATGAAGTGTACCTTTTC TAAAGACGGTTTCCAGCTGCAACGGCTCCACTTTGCAGGCTTGCAGGGTGTATACCTGCGCATTGGGAACTTGCTGGAACCCCTGATGCA TTTTCCTTGAGAGCAGGGGTACTTCCGCCTTGCCGTTAGCTTGTGGAGAACGTGCTTCTTATTCCTGGCAGGCTTCAAGAACAGCTGCAC ATGTGCCGCTAACTGACCGCGTTGCCATTGGCGACCTGGACTCTGAACTCAGGTTTATTCTAAACCCAGTGAGAGGTGAGGGGGAGTGAT GAAAGGGGATCAGCTGTATTTGTGTGTGTGTGTGTGTGTGAGCACCTGACAAATCTATGAAACCGAGTGAAAGGAGAAATGTTAGATTCT TTATTATTTTATTATATTTATATGGAAAGCTCGACTCTCCCTTTGGTAAGTCCGAAGCATGTTGTCTGTTCGACCGTGACTGTCTTCCTC AGTCTGTGCCTGTGATTCCAGTCACCCTGTAGTTACTGACAGAAATTGACTGGACTGTCATTGTGTGAAGTCTAGGAGGAAATGTCCATT TTAATTGTATGATTTGGTCATAAGTAAGGACTATATTTATGTCACCATTATTAGATATATGTACTTTTGTAATGACTGTGAAATACACTT TTCCCTCACTACGACTGCTTCTTTATTTGCTGATAAATCTTAAAACAACTAAGTACGTTGCAAATAATAGTACAGGTACCATCTTTTATG TGAAGTTCTTTTTCTTTTTTTGAGACAGGGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGCACAATCACAGTTCACTGCAGCCTCAA CCTCTCCAGATTCAAGTGATCCTCCCATCTCAGCCTCCCAAGTAGCTGGGACTACAGTTGTGCACCACAATGCCTAGCTAATTTTTTTTG TATTTTGTAGAAATGGGGTTTCGCCATGTTGCTCAGGCTGATCTCAAACTCCTGGGCTCCAACGATCTGCCCACCTTGGCCTCCCAAAGT GCTGAGATTACAGGCGTGAGCCACTGTGCCTGGCCTTATGTAAAGCTCTTGACCTAGCATCTGACTGGAAACAAGCGGGAATTGCATTGG GGGGCATTTTCTGGGCCAGTTTCCCTGCCTTATTTTACCTGCAATAGGTGTGCCTACAAAAGTCTTTCTGACATACACACTGCAGGTGGC AGTTCAAGAAGAATCAACCTTTTTCATTTGGGGATATTAGGATCTTCCTTGGAGACTCTGAAAATGGCACACAAAGAATGGCAGTTATGA ACGTGACTTCTAGATTTTGTCCTTGTAGGAGGCCTTGGTCATGGATAGGGGAAGAGGGATGATGGGATGGAATGGGAGGGTGGGATCTAG ATGACCTCTTGAAATTGTCCCAGTTACTGCTTCCTTCATAACTGTTCACAAAACGTTTTTCATATATACCACCTTGTTTCCCCTGGGAAG TGAGGGGACGAAGCCTTAGAGGGTGACATAGCTAGAAAGTGGAGAAGCTCACTGTTCACTGTGCAAAGCCCCAGTAGTCGGATTCCGGGG AAAAGAACAAGTATCTAGTTTTGATGACAATGTTTTCTTGTAAGAATCCCAACACTTTAGAATAGAAAAGGACCTAAGATTCTCTGGCTC AGCCCCAGCCTTTCTGAAGAAGGGAAAACTAGGGACCCAGATGGTTTAAGGACACCCCAGAGTCCCCAGATGAGCTGGCATTTGAGCTGG TCTGGAGCAGAGTTTCTCCCTCAAAGAACACAGAGAAATCAGAGAGTGGCTGCCATGGTCAGAGGGGGATGTCAACAACAGATCAAGCCG TCATCACAACAGGTATTTCTGAAGTTCCTGCAGGGACTAGGTCTTGCATTTTTAAGTCCTTTTCAAAACTGTGCAGCTTCCTGAACCTTA TGCTGTTTGTCCCATCCACTCTTGAAGCTGGGGAAAGACAGCTTTCTTTGGGAACTCTGTCTTTCTCAGTTGACTTCCCAAGTAAGCAGC AAACCCCTGGATAGCCTTGTTATCTACTTTAGGTATTAAGAGGCTATTGGGTTTTACTAGATTAAATCAATAAAACATTTCCTATAGAGC CATATCATACACTGAAGCAAATTCAGAAAGAATGCAAAACTGCTATCTTTTGGGGGAGTCTGGAAGCCTGTTGGTTAGTGTATTTATTTT CTTTGTGGGGTCTTCTGTGAGCTACAGGCACAGTAAGAATAATTCAGAGCGGTACTGGGAGTTGGTTCAATTTCATGTCATCACTTTTCA ATGAAGGGAGTGCATTTCCTGAGTAGTAAATGAGTATATTATTTGTGGCAGCTTTTCTGTTAAGGGAGCTTTCCAGACATCTGGTTGCAA AGACAAATAGGATATATATTTGTACTTCTTCTCTGTGGACATGTTTTTGTGACACACAGTTATCTCTAGGAGTTGACGTCTGTGGGCACT AAGGGACTGAGGTTGGGGGAGAAAGCTGAGGAGGCTTTGGAAGAGAAGGTGAGGAGCATTTCAGGATTTGCAGTCCCCCTCCACATGTAT CCACATCTGAGCTGGTGGTGTTCCAATAATGAGGCATTTGGGGCAACCAATTTTGGAAGGATAGAATAGCTTTATGTGGAGCAAACTTGA GGATCAATTGGAGTTGAGTGGTTTAAAACTTAAAGATGGCACAGGAAGCTGTATCATTTACAGGTGAAAAAAATAAATGGGTCTGACTTC >27759_27759_2_EVA1C-HUNK_EVA1C_chr21_33840156_ENST00000382699_HUNK_chr21_33318348_ENST00000270112_length(amino acids)=732AA_BP=221 MRLRPAAQRTMLLPGRARQPPTPQPVQHPGLRRQVEPPGQLLRLFYCTVLVCSKEISALTDFSGYLTKLLQNHTTYACDGDYLNLQCPRH STISVQSAFYGQDYQMCSSQKPASQREDSLTCVAATTFQKVLDECQNQRACHLLVNSRVFGPDLCPGSSKYLLVSFKCQPNELKNKTVCE DQELKLHCHESKFLNIYSATYGRRTQERDICSSKAERLPPFDFGLSNCAGILGYSDPFSTQCGSPAYAAPELLARKKYGPKIDVWSIGVN MYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQLSTGAISFLRSLLEPDPVKRPNIQQALANRWLNENYTGKVPCNVTYPNRISLED LSPSVVLHMTEKLGYKNSDVINTVLSNRACHILAIYFLLNKKLERYLSGKSDIQDSLCYKTRLYQIEKYRAPKESYEASLDTWTRDLEFH AVQDKKPKEQEKRGDFLHRPFSKKLDKNLPSHKQPSGSLMTQIQNTKALLKDRKASKSSFPDKDSFGCRNIFRKTSDSNCVASSSMEFIP VPPPRTPRIVKKPEPHQPGPGSTGIPHKEDPLMLDMVRSFESVDRDDHVEVLSPSHHYRILNSPVSLARRNSSERTLSPGLPSGSMSPLH TPLHPTLVSFAHEDKNSPPKEEGLCCPPPVPSNGPMQPLGSPNCVKSRGRFPMMGIGQMLRKRHQSLQPSADRPLEASLPPLQPLAPVNL -------------------------------------------------------------- >27759_27759_3_EVA1C-HUNK_EVA1C_chr21_33840156_ENST00000401402_HUNK_chr21_33318348_ENST00000270112_length(transcript)=7218nt_BP=803nt CCTGGGCTGGCCCGCGCAGGGGAGGAGGCTCTGGCAGCCTGGGCAGGGAGGCGGCGGGGGGCCGCGGAGCCGCTGGCCATCGATTCTCCC CGCCATGTGACGCCGTCCTTAGCCCTGCGACCCCCAGCGCGTCCCGGGCCTGCGCCTCCGCCCCGCCGCGCAGCGCACGATGCTTCTGCC GGGACGCGCACGCCAACCGCCGACGCCCCAGCCCGTGCAGCATCCCGGCCTCCGCCGGCAGGTAGAGCCGCCGGGGCAGCTCCTGCGCCT CTTCTACTGCACTGTCCTGGTCTGCTCCAAAGAGATCTCAGCGCTCACCGACTTCTCTGGTTACCTAACCAAACTCCTGCAAAACCACAC CACCTATGCCTGTGATGGGGACTATTTGAATCTACAGTGCCCTCGGCATTCTACGATAAGTGTCCAATCGGCATTTTATGGGCAAGATTA CCAAATGTGTAGTTCCCAGAAGCCTGCCTCCCAGAGGGAAGACAGCTTAACCTGTGTGGCAGCCACCACCTTCCAGAAGGTGCTGGACGA ATGCCAGAACCAGCGGGCCTGCCACCTCCTGGTCAATAGCCGTGTTTTTGGACCTGACCTTTGTCCAGGAAGCAGTAAATACCTCCTGGT CTCCTTTAAATGCCAACCTAATGAATTAAAAAACAAAACCGTGTGTGAAGACCAGGAGCTGAAACTGCACTGCCATGAATCCAAGTTCCT CAACATCTACTCTGCGACCTACGGCAGGAGGACCCAGGAAAGGGACATCTGCTCCTCCAAGGCAGAGCGGCTCCCCCCTTTCGACTTTGG TTTGAGCAACTGCGCAGGGATCCTGGGTTACTCGGATCCGTTCAGCACACAGTGTGGCAGCCCTGCCTACGCTGCACCTGAACTGCTCGC CAGGAAGAAATACGGCCCCAAAATCGATGTCTGGTCCATAGGTGTGAACATGTATGCCATGTTGACCGGGACGCTGCCTTTCACGGTGGA GCCTTTCAGCCTGAGGGCTTTGTACCAGAAGATGGTAGACAAAGAAATGAACCCCCTCCCCACTCAGCTCTCCACAGGTGCCATCAGTTT CCTGCGCTCTCTCCTGGAACCGGATCCTGTGAAGAGGCCAAATATTCAGCAGGCACTGGCGAATCGCTGGCTTAATGAGAATTACACGGG CAAAGTGCCCTGTAATGTCACCTATCCCAACAGGATTTCTCTGGAAGATCTGAGCCCGAGCGTCGTGCTGCACATGACCGAGAAGCTGGG TTACAAGAACAGCGACGTGATCAACACTGTGCTCTCCAACCGCGCCTGCCACATCCTGGCCATCTACTTCCTCTTAAACAAGAAACTGGA GCGCTATTTGTCAGGGAAATCTGACATCCAGGACAGCCTCTGCTACAAGACCCGGCTCTACCAGATAGAAAAGTACAGGGCCCCCAAGGA GTCCTATGAGGCCTCTCTGGACACCTGGACACGAGATCTTGAATTCCATGCCGTGCAGGATAAAAAGCCCAAAGAACAAGAAAAAAGAGG GGATTTTCTTCATCGACCATTCTCCAAGAAGTTGGACAAGAACCTGCCCTCGCACAAACAGCCCTCAGGCTCGCTTATGACACAGATTCA GAACACCAAAGCCCTCCTGAAGGACCGGAAGGCCTCCAAGTCCAGCTTCCCCGACAAAGATTCCTTTGGCTGCCGCAATATTTTCCGCAA AACCTCAGATTCCAATTGTGTGGCTTCTTCTTCCATGGAGTTCATCCCCGTGCCACCGCCCAGGACCCCGAGGATTGTGAAGAAACCGGA GCCCCATCAGCCAGGGCCCGGAAGCACTGGCATCCCCCACAAGGAAGACCCCCTGATGCTGGACATGGTGCGCTCCTTCGAGTCTGTGGA TCGCGACGACCACGTAGAAGTGCTGTCTCCCTCTCATCACTACAGGATTCTGAACTCCCCGGTCAGCTTGGCTCGCAGAAATTCCAGCGA GAGGACGCTGTCCCCGGGTCTGCCATCCGGAAGCATGTCGCCTCTCCATACTCCTTTGCATCCAACTCTGGTCTCTTTTGCTCACGAAGA TAAGAACAGCCCCCCAAAAGAGGAGGGCCTGTGTTGCCCACCTCCGGTTCCCAGCAATGGCCCCATGCAGCCTCTGGGGAGCCCCAATTG TGTGAAAAGCCGAGGCCGGTTCCCTATGATGGGCATCGGACAGATGTTAAGGAAGCGCCATCAGAGTCTGCAGCCATCTGCAGATAGGCC CCTGGAGGCCAGCCTGCCCCCACTGCAGCCCCTAGCCCCTGTGAACCTTGCCTTTGACATGGCCGATGGGGTCAAGACCCAGTGCTAACT TGGGCCAGCGGGGTTTGGGGTATCTCTAGAAAACAGCAACTGAACAGAGCTCCACACATCTGTCAGGGTGTGAGCACTCCAAGGCCTCGC GTGGAGCATCCTTAGTCCCACCTGTAGCTGAATCCACAGACCCAAAGCCTGCACAACCCAACCTCGCTTAGGGACCCCCAGAGATGCTGG AATCGCTAGGAGGGTTGGCTCCAGGGGCAGCCAATTCCTATCATTCAGATCTTCCTTCCTCCCAAGTACTCACCAACCCCTTCCACTTCC CACTTCCCCCAGGCTTGGGGGGAAAACAGGGCATGAGCCTTCTGGGGCACTCAGATTATGGACTGTTACCAGATCTTTCTTCACGCTGTG CTACATGTGTGCCTCTCACAGCAGTTGGCCACAGTTACAGGGAGAGAACAATATCACAGTCATTCATCCAGGCCACGTTTCCTCTGCGGA GTGTAGCAGCCCTGCCTTTCATAGCAGGGATTACCTGAAGGCCAGCAGGAGCCGGGGGCAGGCCCAGGATCCTCAGAGGAAGATGGAGAG GAGCTTCGGACCAAGATCAAACCAAACAGTGGGGACCCCAACAGAAGAGAAAGACTGAAGGAGACACTCATTTCCCAAGCAAGATTTTGA TAGATTTTTGTTGTTGTTGTTGTTGAAACATGCTAATGATTGAATTATCTTTTCCAAAGATTTTTTTTAAATGTGATGTCGGTAAATTGA AATAACATAATTTTTTAAAACTTGGATGGAGAGATGAGAAGCAATTCCACCAAACTCATGTTTTCACAGGAGGGTTCAGTGTGGAGAGCA AAAAAGCTGACTGTGGTGATTTGCTGAGTGCTGTGGCCCACAGGCAGGGCAAGTCTCGGTGGCCCTGTGTTCATCCTGTTGTTTAAGGCA TAGCCCTGATCCTTCTGGAAGGCATAGAACACGGTTACAGCTGGTTCTGTAGAAAGAGGGAAAAGATGATTGTGACAATTCAGAGCATAA CTCAGATGGCGAGAAGGCAGCATTATCTCTGTGCGATGCTGATTTCAAGCTGCCCACAGAACTGGTGCGGCTCAGAGCTCGGCGAGTTTG CTGGGAGCTGGGAGCAGGCTTGCCTGGCAGAGAACCTGTTCAGATACAGGCCAGTTTCTTCTTCGAGGAAAGCCAAGCTCCTCAAACAGG GTTCAGTCCACGTTGTGTTTTCACACCTTTCTCCAAGGATCGAACCAAAGATGTGTCTCCAGTATTGTGTCTGTGCCCCTGTGTGTGTTT TGTGGACAGCCGTGTTGTCTGACTGTATCCAGCTGGCACTTGACAGGGTGCAGTCATTGGTGAGAAGAATCAGAAAAAGAAGACCCATCA GCACAGGTTGGATAGGGGTTAGTGTAGGAGACCAGTTACAGAATGGCCTGGAGTCTTCAACTTTTGACCGGTGCAGGTGTGACCAGAGAC CACCTCTGTGGCCACCTCAGATAGTCATCTCAGTCCAAGGATCCCAAAACACAAATCTAGAATTGCAAAGCCAGCCTTTATTTCCCTGGC AGGCAGCCTTGCCAGAAGGCAGAGAGGCAGTTCTGAATCATTCTCTCATTCACCAGTGGTGACATCCTTCAGTCCCTCACATCTCTGACA GAGCGGGACAGAATGGATATTTGGCTGACCTTGGTGAGACCTGGAGCTGCCTGTTTCTTCCCTAGGGGATCACCACGGCTCTAGGGCATT CTAGGATGAGGTCAGACCCCTTGGCCATTGGTGTTATTTTTTGTATAGCTTCAGACTGGGTTCCAGAACTTACCATTGAAAACAGAGCTT TTAGGCCAGGTGTGGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGTGGATCGCTTGAGCTCAGGAGTTCGAGAGCA GCCTGGGCAACATGGTGAAAGCCCGTCTCTACCGAAAAATACAAAAAAAAATAGCTGGGTGTGGTGGTACGTGCCTGTAGTCCCAGCTAC TTCGGGGACTGAGGTGGGAGGATCACTTGAACCTAGGAGGTCGAGGCTGCAGTGAGCCAAGATCATGCTACTGCACTCCAGCTTAGGTGG CAAAGTGAGACCCTGTCTCCAAAAAAAGAAAATAGAGCTTTATAAGCAGAGAGAAGAAAATAATCATCTAAGACCATCTCTCCATTCGAC ATGAAGTGTACCTTTTCTAAAGACGGTTTCCAGCTGCAACGGCTCCACTTTGCAGGCTTGCAGGGTGTATACCTGCGCATTGGGAACTTG CTGGAACCCCTGATGCATTTTCCTTGAGAGCAGGGGTACTTCCGCCTTGCCGTTAGCTTGTGGAGAACGTGCTTCTTATTCCTGGCAGGC TTCAAGAACAGCTGCACATGTGCCGCTAACTGACCGCGTTGCCATTGGCGACCTGGACTCTGAACTCAGGTTTATTCTAAACCCAGTGAG AGGTGAGGGGGAGTGATGAAAGGGGATCAGCTGTATTTGTGTGTGTGTGTGTGTGTGAGCACCTGACAAATCTATGAAACCGAGTGAAAG GAGAAATGTTAGATTCTTTATTATTTTATTATATTTATATGGAAAGCTCGACTCTCCCTTTGGTAAGTCCGAAGCATGTTGTCTGTTCGA CCGTGACTGTCTTCCTCAGTCTGTGCCTGTGATTCCAGTCACCCTGTAGTTACTGACAGAAATTGACTGGACTGTCATTGTGTGAAGTCT AGGAGGAAATGTCCATTTTAATTGTATGATTTGGTCATAAGTAAGGACTATATTTATGTCACCATTATTAGATATATGTACTTTTGTAAT GACTGTGAAATACACTTTTCCCTCACTACGACTGCTTCTTTATTTGCTGATAAATCTTAAAACAACTAAGTACGTTGCAAATAATAGTAC AGGTACCATCTTTTATGTGAAGTTCTTTTTCTTTTTTTGAGACAGGGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGCACAATCACA GTTCACTGCAGCCTCAACCTCTCCAGATTCAAGTGATCCTCCCATCTCAGCCTCCCAAGTAGCTGGGACTACAGTTGTGCACCACAATGC CTAGCTAATTTTTTTTGTATTTTGTAGAAATGGGGTTTCGCCATGTTGCTCAGGCTGATCTCAAACTCCTGGGCTCCAACGATCTGCCCA CCTTGGCCTCCCAAAGTGCTGAGATTACAGGCGTGAGCCACTGTGCCTGGCCTTATGTAAAGCTCTTGACCTAGCATCTGACTGGAAACA AGCGGGAATTGCATTGGGGGGCATTTTCTGGGCCAGTTTCCCTGCCTTATTTTACCTGCAATAGGTGTGCCTACAAAAGTCTTTCTGACA TACACACTGCAGGTGGCAGTTCAAGAAGAATCAACCTTTTTCATTTGGGGATATTAGGATCTTCCTTGGAGACTCTGAAAATGGCACACA AAGAATGGCAGTTATGAACGTGACTTCTAGATTTTGTCCTTGTAGGAGGCCTTGGTCATGGATAGGGGAAGAGGGATGATGGGATGGAAT GGGAGGGTGGGATCTAGATGACCTCTTGAAATTGTCCCAGTTACTGCTTCCTTCATAACTGTTCACAAAACGTTTTTCATATATACCACC TTGTTTCCCCTGGGAAGTGAGGGGACGAAGCCTTAGAGGGTGACATAGCTAGAAAGTGGAGAAGCTCACTGTTCACTGTGCAAAGCCCCA GTAGTCGGATTCCGGGGAAAAGAACAAGTATCTAGTTTTGATGACAATGTTTTCTTGTAAGAATCCCAACACTTTAGAATAGAAAAGGAC CTAAGATTCTCTGGCTCAGCCCCAGCCTTTCTGAAGAAGGGAAAACTAGGGACCCAGATGGTTTAAGGACACCCCAGAGTCCCCAGATGA GCTGGCATTTGAGCTGGTCTGGAGCAGAGTTTCTCCCTCAAAGAACACAGAGAAATCAGAGAGTGGCTGCCATGGTCAGAGGGGGATGTC AACAACAGATCAAGCCGTCATCACAACAGGTATTTCTGAAGTTCCTGCAGGGACTAGGTCTTGCATTTTTAAGTCCTTTTCAAAACTGTG CAGCTTCCTGAACCTTATGCTGTTTGTCCCATCCACTCTTGAAGCTGGGGAAAGACAGCTTTCTTTGGGAACTCTGTCTTTCTCAGTTGA CTTCCCAAGTAAGCAGCAAACCCCTGGATAGCCTTGTTATCTACTTTAGGTATTAAGAGGCTATTGGGTTTTACTAGATTAAATCAATAA AACATTTCCTATAGAGCCATATCATACACTGAAGCAAATTCAGAAAGAATGCAAAACTGCTATCTTTTGGGGGAGTCTGGAAGCCTGTTG GTTAGTGTATTTATTTTCTTTGTGGGGTCTTCTGTGAGCTACAGGCACAGTAAGAATAATTCAGAGCGGTACTGGGAGTTGGTTCAATTT CATGTCATCACTTTTCAATGAAGGGAGTGCATTTCCTGAGTAGTAAATGAGTATATTATTTGTGGCAGCTTTTCTGTTAAGGGAGCTTTC CAGACATCTGGTTGCAAAGACAAATAGGATATATATTTGTACTTCTTCTCTGTGGACATGTTTTTGTGACACACAGTTATCTCTAGGAGT TGACGTCTGTGGGCACTAAGGGACTGAGGTTGGGGGAGAAAGCTGAGGAGGCTTTGGAAGAGAAGGTGAGGAGCATTTCAGGATTTGCAG TCCCCCTCCACATGTATCCACATCTGAGCTGGTGGTGTTCCAATAATGAGGCATTTGGGGCAACCAATTTTGGAAGGATAGAATAGCTTT ATGTGGAGCAAACTTGAGGATCAATTGGAGTTGAGTGGTTTAAAACTTAAAGATGGCACAGGAAGCTGTATCATTTACAGGTGAAAAAAA >27759_27759_3_EVA1C-HUNK_EVA1C_chr21_33840156_ENST00000401402_HUNK_chr21_33318348_ENST00000270112_length(amino acids)=732AA_BP=221 MRLRPAAQRTMLLPGRARQPPTPQPVQHPGLRRQVEPPGQLLRLFYCTVLVCSKEISALTDFSGYLTKLLQNHTTYACDGDYLNLQCPRH STISVQSAFYGQDYQMCSSQKPASQREDSLTCVAATTFQKVLDECQNQRACHLLVNSRVFGPDLCPGSSKYLLVSFKCQPNELKNKTVCE DQELKLHCHESKFLNIYSATYGRRTQERDICSSKAERLPPFDFGLSNCAGILGYSDPFSTQCGSPAYAAPELLARKKYGPKIDVWSIGVN MYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQLSTGAISFLRSLLEPDPVKRPNIQQALANRWLNENYTGKVPCNVTYPNRISLED LSPSVVLHMTEKLGYKNSDVINTVLSNRACHILAIYFLLNKKLERYLSGKSDIQDSLCYKTRLYQIEKYRAPKESYEASLDTWTRDLEFH AVQDKKPKEQEKRGDFLHRPFSKKLDKNLPSHKQPSGSLMTQIQNTKALLKDRKASKSSFPDKDSFGCRNIFRKTSDSNCVASSSMEFIP VPPPRTPRIVKKPEPHQPGPGSTGIPHKEDPLMLDMVRSFESVDRDDHVEVLSPSHHYRILNSPVSLARRNSSERTLSPGLPSGSMSPLH TPLHPTLVSFAHEDKNSPPKEEGLCCPPPVPSNGPMQPLGSPNCVKSRGRFPMMGIGQMLRKRHQSLQPSADRPLEASLPPLQPLAPVNL -------------------------------------------------------------- |
Top |
Fusion Gene PPI Analysis for EVA1C-HUNK |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs for EVA1C-HUNK |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
Related Diseases for EVA1C-HUNK |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2021-Present -The University of Texas Health Science Center at Houston (UTHealth)
Web File Viewing | Emergency Information |Campus Carry|Site Policies