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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:EWSR1-EMID1 (FusionGDB2 ID:27827)

Fusion Gene Summary for EWSR1-EMID1

Fusion gene summary

Fusion gene information	Fusion gene name: EWSR1-EMID1
	Fusion gene ID: 27827
		Hgene	Tgene
	Gene symbol	EWSR1	EMID1
	Gene ID	2130	129080
	Gene name	EWS RNA binding protein 1	EMI domain containing 1
	Synonyms	EWS\|EWS-FLI1\|bK984G1.4	EMI5\|EMU1
	Cytomap	22q12.2	22q12.2
	Type of gene	protein-coding	protein-coding
	Description	RNA-binding protein EWSEWS RNA-binding protein variant 6Ewing sarcoma breakpoint region 1Ewings sarcoma EWS-Fli1 (type 1) oncogene	EMI domain-containing protein 1emilin and multimerin domain-containing protein 1
	Modification date	20200329	20200313
	UniProtAcc	Q01844	Q96A84
	Ensembl transtripts involved in fusion gene	ENST00000331029, ENST00000332035, ENST00000332050, ENST00000333395, ENST00000397938, ENST00000406548, ENST00000414183,	ENST00000404755, ENST00000404820, ENST00000484039, ENST00000334018,
Fusion gene scores	* DoF score	44 X 91 X 16=64064	9 X 12 X 7=756
	# samples	98	12
	** MAII score	log2(98/64064*10)=-6.03058831983342 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(12/756*10)=-2.65535182861255 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: EWSR1 [Title/Abstract] AND EMID1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	EWSR1(29669853)-EMID1(29650191), # samples:1 EWSR1(29674205)-EMID1(29639433), # samples:1 EWSR1(29669853)-EMID1(29650192), # samples:1 EWSR1(29674205)-EMID1(29639434), # samples:1 EWSR1(29674205)-EMID1(29650192), # samples:1 EWSR1(29674205)-EMID1(29654806), # samples:1
Anticipated loss of major functional domain due to fusion event.	EWSR1-EMID1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. EWSR1-EMID1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across EWSR1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across EMID1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	OV	TCGA-24-0968-01A	EWSR1	chr22	29669853	+	EMID1	chr22	29650192	+
ChimerDB4	OV	TCGA-24-0968-01A	EWSR1	chr22	29674205	+	EMID1	chr22	29639434	+
ChimerDB4	OV	TCGA-24-0968-01A	EWSR1	chr22	29674205	+	EMID1	chr22	29650192	+
ChimerDB4	OV	TCGA-24-0968-01A	EWSR1	chr22	29674205	+	EMID1	chr22	29654806	+
ChimerDB4	OV	TCGA-24-0968	EWSR1	chr22	29669853	+	EMID1	chr22	29650191	+
ChimerDB4	OV	TCGA-24-0968	EWSR1	chr22	29674205	+	EMID1	chr22	29639433	+

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Fusion Gene ORF analysis for EWSR1-EMID1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000331029	ENST00000404755	EWSR1	chr22	29669853	+	EMID1	chr22	29650192	+
5CDS-intron	ENST00000331029	ENST00000404755	EWSR1	chr22	29674205	+	EMID1	chr22	29650192	+
5CDS-intron	ENST00000331029	ENST00000404755	EWSR1	chr22	29669853	+	EMID1	chr22	29650191	+
5CDS-intron	ENST00000331029	ENST00000404820	EWSR1	chr22	29669853	+	EMID1	chr22	29650192	+
5CDS-intron	ENST00000331029	ENST00000404820	EWSR1	chr22	29674205	+	EMID1	chr22	29650192	+
5CDS-intron	ENST00000331029	ENST00000404820	EWSR1	chr22	29669853	+	EMID1	chr22	29650191	+
5CDS-intron	ENST00000331029	ENST00000484039	EWSR1	chr22	29669853	+	EMID1	chr22	29650192	+
5CDS-intron	ENST00000331029	ENST00000484039	EWSR1	chr22	29674205	+	EMID1	chr22	29639434	+
5CDS-intron	ENST00000331029	ENST00000484039	EWSR1	chr22	29674205	+	EMID1	chr22	29650192	+
5CDS-intron	ENST00000331029	ENST00000484039	EWSR1	chr22	29674205	+	EMID1	chr22	29654806	+
5CDS-intron	ENST00000331029	ENST00000484039	EWSR1	chr22	29669853	+	EMID1	chr22	29650191	+
5CDS-intron	ENST00000331029	ENST00000484039	EWSR1	chr22	29674205	+	EMID1	chr22	29639433	+
5CDS-intron	ENST00000332035	ENST00000404755	EWSR1	chr22	29669853	+	EMID1	chr22	29650192	+
5CDS-intron	ENST00000332035	ENST00000404755	EWSR1	chr22	29674205	+	EMID1	chr22	29650192	+
5CDS-intron	ENST00000332035	ENST00000404755	EWSR1	chr22	29669853	+	EMID1	chr22	29650191	+
5CDS-intron	ENST00000332035	ENST00000404820	EWSR1	chr22	29669853	+	EMID1	chr22	29650192	+
5CDS-intron	ENST00000332035	ENST00000404820	EWSR1	chr22	29674205	+	EMID1	chr22	29650192	+
5CDS-intron	ENST00000332035	ENST00000404820	EWSR1	chr22	29669853	+	EMID1	chr22	29650191	+
5CDS-intron	ENST00000332035	ENST00000484039	EWSR1	chr22	29669853	+	EMID1	chr22	29650192	+
5CDS-intron	ENST00000332035	ENST00000484039	EWSR1	chr22	29674205	+	EMID1	chr22	29639434	+
5CDS-intron	ENST00000332035	ENST00000484039	EWSR1	chr22	29674205	+	EMID1	chr22	29650192	+
5CDS-intron	ENST00000332035	ENST00000484039	EWSR1	chr22	29674205	+	EMID1	chr22	29654806	+
5CDS-intron	ENST00000332035	ENST00000484039	EWSR1	chr22	29669853	+	EMID1	chr22	29650191	+
5CDS-intron	ENST00000332035	ENST00000484039	EWSR1	chr22	29674205	+	EMID1	chr22	29639433	+
5CDS-intron	ENST00000332050	ENST00000404755	EWSR1	chr22	29669853	+	EMID1	chr22	29650192	+
5CDS-intron	ENST00000332050	ENST00000404755	EWSR1	chr22	29674205	+	EMID1	chr22	29650192	+
5CDS-intron	ENST00000332050	ENST00000404755	EWSR1	chr22	29669853	+	EMID1	chr22	29650191	+
5CDS-intron	ENST00000332050	ENST00000404820	EWSR1	chr22	29669853	+	EMID1	chr22	29650192	+
5CDS-intron	ENST00000332050	ENST00000404820	EWSR1	chr22	29674205	+	EMID1	chr22	29650192	+
5CDS-intron	ENST00000332050	ENST00000404820	EWSR1	chr22	29669853	+	EMID1	chr22	29650191	+
5CDS-intron	ENST00000332050	ENST00000484039	EWSR1	chr22	29669853	+	EMID1	chr22	29650192	+
5CDS-intron	ENST00000332050	ENST00000484039	EWSR1	chr22	29674205	+	EMID1	chr22	29639434	+
5CDS-intron	ENST00000332050	ENST00000484039	EWSR1	chr22	29674205	+	EMID1	chr22	29650192	+
5CDS-intron	ENST00000332050	ENST00000484039	EWSR1	chr22	29674205	+	EMID1	chr22	29654806	+
5CDS-intron	ENST00000332050	ENST00000484039	EWSR1	chr22	29669853	+	EMID1	chr22	29650191	+
5CDS-intron	ENST00000332050	ENST00000484039	EWSR1	chr22	29674205	+	EMID1	chr22	29639433	+
5CDS-intron	ENST00000333395	ENST00000404755	EWSR1	chr22	29669853	+	EMID1	chr22	29650192	+
5CDS-intron	ENST00000333395	ENST00000404755	EWSR1	chr22	29674205	+	EMID1	chr22	29650192	+
5CDS-intron	ENST00000333395	ENST00000404755	EWSR1	chr22	29669853	+	EMID1	chr22	29650191	+
5CDS-intron	ENST00000333395	ENST00000404820	EWSR1	chr22	29669853	+	EMID1	chr22	29650192	+
5CDS-intron	ENST00000333395	ENST00000404820	EWSR1	chr22	29674205	+	EMID1	chr22	29650192	+
5CDS-intron	ENST00000333395	ENST00000404820	EWSR1	chr22	29669853	+	EMID1	chr22	29650191	+
5CDS-intron	ENST00000333395	ENST00000484039	EWSR1	chr22	29669853	+	EMID1	chr22	29650192	+
5CDS-intron	ENST00000333395	ENST00000484039	EWSR1	chr22	29674205	+	EMID1	chr22	29639434	+
5CDS-intron	ENST00000333395	ENST00000484039	EWSR1	chr22	29674205	+	EMID1	chr22	29650192	+
5CDS-intron	ENST00000333395	ENST00000484039	EWSR1	chr22	29674205	+	EMID1	chr22	29654806	+
5CDS-intron	ENST00000333395	ENST00000484039	EWSR1	chr22	29669853	+	EMID1	chr22	29650191	+
5CDS-intron	ENST00000333395	ENST00000484039	EWSR1	chr22	29674205	+	EMID1	chr22	29639433	+
5CDS-intron	ENST00000397938	ENST00000404755	EWSR1	chr22	29669853	+	EMID1	chr22	29650192	+
5CDS-intron	ENST00000397938	ENST00000404755	EWSR1	chr22	29674205	+	EMID1	chr22	29650192	+
5CDS-intron	ENST00000397938	ENST00000404755	EWSR1	chr22	29669853	+	EMID1	chr22	29650191	+
5CDS-intron	ENST00000397938	ENST00000404820	EWSR1	chr22	29669853	+	EMID1	chr22	29650192	+
5CDS-intron	ENST00000397938	ENST00000404820	EWSR1	chr22	29674205	+	EMID1	chr22	29650192	+
5CDS-intron	ENST00000397938	ENST00000404820	EWSR1	chr22	29669853	+	EMID1	chr22	29650191	+
5CDS-intron	ENST00000397938	ENST00000484039	EWSR1	chr22	29669853	+	EMID1	chr22	29650192	+
5CDS-intron	ENST00000397938	ENST00000484039	EWSR1	chr22	29674205	+	EMID1	chr22	29639434	+
5CDS-intron	ENST00000397938	ENST00000484039	EWSR1	chr22	29674205	+	EMID1	chr22	29650192	+
5CDS-intron	ENST00000397938	ENST00000484039	EWSR1	chr22	29674205	+	EMID1	chr22	29654806	+
5CDS-intron	ENST00000397938	ENST00000484039	EWSR1	chr22	29669853	+	EMID1	chr22	29650191	+
5CDS-intron	ENST00000397938	ENST00000484039	EWSR1	chr22	29674205	+	EMID1	chr22	29639433	+
5CDS-intron	ENST00000406548	ENST00000404755	EWSR1	chr22	29669853	+	EMID1	chr22	29650192	+
5CDS-intron	ENST00000406548	ENST00000404755	EWSR1	chr22	29674205	+	EMID1	chr22	29650192	+
5CDS-intron	ENST00000406548	ENST00000404755	EWSR1	chr22	29669853	+	EMID1	chr22	29650191	+
5CDS-intron	ENST00000406548	ENST00000404820	EWSR1	chr22	29669853	+	EMID1	chr22	29650192	+
5CDS-intron	ENST00000406548	ENST00000404820	EWSR1	chr22	29674205	+	EMID1	chr22	29650192	+
5CDS-intron	ENST00000406548	ENST00000404820	EWSR1	chr22	29669853	+	EMID1	chr22	29650191	+
5CDS-intron	ENST00000406548	ENST00000484039	EWSR1	chr22	29669853	+	EMID1	chr22	29650192	+
5CDS-intron	ENST00000406548	ENST00000484039	EWSR1	chr22	29674205	+	EMID1	chr22	29639434	+
5CDS-intron	ENST00000406548	ENST00000484039	EWSR1	chr22	29674205	+	EMID1	chr22	29650192	+
5CDS-intron	ENST00000406548	ENST00000484039	EWSR1	chr22	29674205	+	EMID1	chr22	29654806	+
5CDS-intron	ENST00000406548	ENST00000484039	EWSR1	chr22	29669853	+	EMID1	chr22	29650191	+
5CDS-intron	ENST00000406548	ENST00000484039	EWSR1	chr22	29674205	+	EMID1	chr22	29639433	+
5CDS-intron	ENST00000414183	ENST00000404755	EWSR1	chr22	29669853	+	EMID1	chr22	29650192	+
5CDS-intron	ENST00000414183	ENST00000404755	EWSR1	chr22	29674205	+	EMID1	chr22	29650192	+
5CDS-intron	ENST00000414183	ENST00000404755	EWSR1	chr22	29669853	+	EMID1	chr22	29650191	+
5CDS-intron	ENST00000414183	ENST00000404820	EWSR1	chr22	29669853	+	EMID1	chr22	29650192	+
5CDS-intron	ENST00000414183	ENST00000404820	EWSR1	chr22	29674205	+	EMID1	chr22	29650192	+
5CDS-intron	ENST00000414183	ENST00000404820	EWSR1	chr22	29669853	+	EMID1	chr22	29650191	+
5CDS-intron	ENST00000414183	ENST00000484039	EWSR1	chr22	29669853	+	EMID1	chr22	29650192	+
5CDS-intron	ENST00000414183	ENST00000484039	EWSR1	chr22	29674205	+	EMID1	chr22	29639434	+
5CDS-intron	ENST00000414183	ENST00000484039	EWSR1	chr22	29674205	+	EMID1	chr22	29650192	+
5CDS-intron	ENST00000414183	ENST00000484039	EWSR1	chr22	29674205	+	EMID1	chr22	29654806	+
5CDS-intron	ENST00000414183	ENST00000484039	EWSR1	chr22	29669853	+	EMID1	chr22	29650191	+
5CDS-intron	ENST00000414183	ENST00000484039	EWSR1	chr22	29674205	+	EMID1	chr22	29639433	+
Frame-shift	ENST00000331029	ENST00000334018	EWSR1	chr22	29669853	+	EMID1	chr22	29650192	+
Frame-shift	ENST00000331029	ENST00000334018	EWSR1	chr22	29674205	+	EMID1	chr22	29639434	+
Frame-shift	ENST00000331029	ENST00000334018	EWSR1	chr22	29674205	+	EMID1	chr22	29650192	+
Frame-shift	ENST00000331029	ENST00000334018	EWSR1	chr22	29674205	+	EMID1	chr22	29654806	+
Frame-shift	ENST00000331029	ENST00000334018	EWSR1	chr22	29669853	+	EMID1	chr22	29650191	+
Frame-shift	ENST00000331029	ENST00000334018	EWSR1	chr22	29674205	+	EMID1	chr22	29639433	+
Frame-shift	ENST00000331029	ENST00000404755	EWSR1	chr22	29674205	+	EMID1	chr22	29639434	+
Frame-shift	ENST00000331029	ENST00000404755	EWSR1	chr22	29674205	+	EMID1	chr22	29654806	+
Frame-shift	ENST00000331029	ENST00000404755	EWSR1	chr22	29674205	+	EMID1	chr22	29639433	+
Frame-shift	ENST00000331029	ENST00000404820	EWSR1	chr22	29674205	+	EMID1	chr22	29639434	+
Frame-shift	ENST00000331029	ENST00000404820	EWSR1	chr22	29674205	+	EMID1	chr22	29654806	+
Frame-shift	ENST00000331029	ENST00000404820	EWSR1	chr22	29674205	+	EMID1	chr22	29639433	+
Frame-shift	ENST00000332035	ENST00000334018	EWSR1	chr22	29669853	+	EMID1	chr22	29650192	+
Frame-shift	ENST00000332035	ENST00000334018	EWSR1	chr22	29674205	+	EMID1	chr22	29639434	+
Frame-shift	ENST00000332035	ENST00000334018	EWSR1	chr22	29674205	+	EMID1	chr22	29650192	+
Frame-shift	ENST00000332035	ENST00000334018	EWSR1	chr22	29674205	+	EMID1	chr22	29654806	+
Frame-shift	ENST00000332035	ENST00000334018	EWSR1	chr22	29669853	+	EMID1	chr22	29650191	+
Frame-shift	ENST00000332035	ENST00000334018	EWSR1	chr22	29674205	+	EMID1	chr22	29639433	+
Frame-shift	ENST00000332035	ENST00000404755	EWSR1	chr22	29674205	+	EMID1	chr22	29639434	+
Frame-shift	ENST00000332035	ENST00000404755	EWSR1	chr22	29674205	+	EMID1	chr22	29654806	+
Frame-shift	ENST00000332035	ENST00000404755	EWSR1	chr22	29674205	+	EMID1	chr22	29639433	+
Frame-shift	ENST00000332035	ENST00000404820	EWSR1	chr22	29674205	+	EMID1	chr22	29639434	+
Frame-shift	ENST00000332035	ENST00000404820	EWSR1	chr22	29674205	+	EMID1	chr22	29654806	+
Frame-shift	ENST00000332035	ENST00000404820	EWSR1	chr22	29674205	+	EMID1	chr22	29639433	+
Frame-shift	ENST00000332050	ENST00000334018	EWSR1	chr22	29669853	+	EMID1	chr22	29650192	+
Frame-shift	ENST00000332050	ENST00000334018	EWSR1	chr22	29674205	+	EMID1	chr22	29639434	+
Frame-shift	ENST00000332050	ENST00000334018	EWSR1	chr22	29674205	+	EMID1	chr22	29650192	+
Frame-shift	ENST00000332050	ENST00000334018	EWSR1	chr22	29674205	+	EMID1	chr22	29654806	+
Frame-shift	ENST00000332050	ENST00000334018	EWSR1	chr22	29669853	+	EMID1	chr22	29650191	+
Frame-shift	ENST00000332050	ENST00000334018	EWSR1	chr22	29674205	+	EMID1	chr22	29639433	+
Frame-shift	ENST00000332050	ENST00000404755	EWSR1	chr22	29674205	+	EMID1	chr22	29639434	+
Frame-shift	ENST00000332050	ENST00000404755	EWSR1	chr22	29674205	+	EMID1	chr22	29654806	+
Frame-shift	ENST00000332050	ENST00000404755	EWSR1	chr22	29674205	+	EMID1	chr22	29639433	+
Frame-shift	ENST00000332050	ENST00000404820	EWSR1	chr22	29674205	+	EMID1	chr22	29639434	+
Frame-shift	ENST00000332050	ENST00000404820	EWSR1	chr22	29674205	+	EMID1	chr22	29654806	+
Frame-shift	ENST00000332050	ENST00000404820	EWSR1	chr22	29674205	+	EMID1	chr22	29639433	+
Frame-shift	ENST00000333395	ENST00000334018	EWSR1	chr22	29669853	+	EMID1	chr22	29650192	+
Frame-shift	ENST00000333395	ENST00000334018	EWSR1	chr22	29674205	+	EMID1	chr22	29639434	+
Frame-shift	ENST00000333395	ENST00000334018	EWSR1	chr22	29674205	+	EMID1	chr22	29650192	+
Frame-shift	ENST00000333395	ENST00000334018	EWSR1	chr22	29674205	+	EMID1	chr22	29654806	+
Frame-shift	ENST00000333395	ENST00000334018	EWSR1	chr22	29669853	+	EMID1	chr22	29650191	+
Frame-shift	ENST00000333395	ENST00000334018	EWSR1	chr22	29674205	+	EMID1	chr22	29639433	+
Frame-shift	ENST00000333395	ENST00000404755	EWSR1	chr22	29674205	+	EMID1	chr22	29639434	+
Frame-shift	ENST00000333395	ENST00000404755	EWSR1	chr22	29674205	+	EMID1	chr22	29654806	+
Frame-shift	ENST00000333395	ENST00000404755	EWSR1	chr22	29674205	+	EMID1	chr22	29639433	+
Frame-shift	ENST00000333395	ENST00000404820	EWSR1	chr22	29674205	+	EMID1	chr22	29639434	+
Frame-shift	ENST00000333395	ENST00000404820	EWSR1	chr22	29674205	+	EMID1	chr22	29654806	+
Frame-shift	ENST00000333395	ENST00000404820	EWSR1	chr22	29674205	+	EMID1	chr22	29639433	+
Frame-shift	ENST00000397938	ENST00000334018	EWSR1	chr22	29669853	+	EMID1	chr22	29650192	+
Frame-shift	ENST00000397938	ENST00000334018	EWSR1	chr22	29674205	+	EMID1	chr22	29639434	+
Frame-shift	ENST00000397938	ENST00000334018	EWSR1	chr22	29674205	+	EMID1	chr22	29650192	+
Frame-shift	ENST00000397938	ENST00000334018	EWSR1	chr22	29674205	+	EMID1	chr22	29654806	+
Frame-shift	ENST00000397938	ENST00000334018	EWSR1	chr22	29669853	+	EMID1	chr22	29650191	+
Frame-shift	ENST00000397938	ENST00000334018	EWSR1	chr22	29674205	+	EMID1	chr22	29639433	+
Frame-shift	ENST00000397938	ENST00000404755	EWSR1	chr22	29674205	+	EMID1	chr22	29639434	+
Frame-shift	ENST00000397938	ENST00000404755	EWSR1	chr22	29674205	+	EMID1	chr22	29654806	+
Frame-shift	ENST00000397938	ENST00000404755	EWSR1	chr22	29674205	+	EMID1	chr22	29639433	+
Frame-shift	ENST00000397938	ENST00000404820	EWSR1	chr22	29674205	+	EMID1	chr22	29639434	+
Frame-shift	ENST00000397938	ENST00000404820	EWSR1	chr22	29674205	+	EMID1	chr22	29654806	+
Frame-shift	ENST00000397938	ENST00000404820	EWSR1	chr22	29674205	+	EMID1	chr22	29639433	+
Frame-shift	ENST00000406548	ENST00000334018	EWSR1	chr22	29669853	+	EMID1	chr22	29650192	+
Frame-shift	ENST00000406548	ENST00000334018	EWSR1	chr22	29674205	+	EMID1	chr22	29639434	+
Frame-shift	ENST00000406548	ENST00000334018	EWSR1	chr22	29674205	+	EMID1	chr22	29650192	+
Frame-shift	ENST00000406548	ENST00000334018	EWSR1	chr22	29674205	+	EMID1	chr22	29654806	+
Frame-shift	ENST00000406548	ENST00000334018	EWSR1	chr22	29669853	+	EMID1	chr22	29650191	+
Frame-shift	ENST00000406548	ENST00000334018	EWSR1	chr22	29674205	+	EMID1	chr22	29639433	+
Frame-shift	ENST00000406548	ENST00000404755	EWSR1	chr22	29674205	+	EMID1	chr22	29639434	+
Frame-shift	ENST00000406548	ENST00000404755	EWSR1	chr22	29674205	+	EMID1	chr22	29654806	+
Frame-shift	ENST00000406548	ENST00000404755	EWSR1	chr22	29674205	+	EMID1	chr22	29639433	+
Frame-shift	ENST00000406548	ENST00000404820	EWSR1	chr22	29674205	+	EMID1	chr22	29639434	+
Frame-shift	ENST00000406548	ENST00000404820	EWSR1	chr22	29674205	+	EMID1	chr22	29654806	+
Frame-shift	ENST00000406548	ENST00000404820	EWSR1	chr22	29674205	+	EMID1	chr22	29639433	+
Frame-shift	ENST00000414183	ENST00000334018	EWSR1	chr22	29669853	+	EMID1	chr22	29650192	+
Frame-shift	ENST00000414183	ENST00000334018	EWSR1	chr22	29674205	+	EMID1	chr22	29639434	+
Frame-shift	ENST00000414183	ENST00000334018	EWSR1	chr22	29674205	+	EMID1	chr22	29650192	+
Frame-shift	ENST00000414183	ENST00000334018	EWSR1	chr22	29674205	+	EMID1	chr22	29654806	+
Frame-shift	ENST00000414183	ENST00000334018	EWSR1	chr22	29669853	+	EMID1	chr22	29650191	+
Frame-shift	ENST00000414183	ENST00000334018	EWSR1	chr22	29674205	+	EMID1	chr22	29639433	+
Frame-shift	ENST00000414183	ENST00000404755	EWSR1	chr22	29674205	+	EMID1	chr22	29639434	+
Frame-shift	ENST00000414183	ENST00000404755	EWSR1	chr22	29674205	+	EMID1	chr22	29654806	+
Frame-shift	ENST00000414183	ENST00000404755	EWSR1	chr22	29674205	+	EMID1	chr22	29639433	+
Frame-shift	ENST00000414183	ENST00000404820	EWSR1	chr22	29674205	+	EMID1	chr22	29639434	+
Frame-shift	ENST00000414183	ENST00000404820	EWSR1	chr22	29674205	+	EMID1	chr22	29654806	+
Frame-shift	ENST00000414183	ENST00000404820	EWSR1	chr22	29674205	+	EMID1	chr22	29639433	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for EWSR1-EMID1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
EWSR1	chr22	29669853	+	EMID1	chr22	29650191	+	2.68E-05	0.9999732
EWSR1	chr22	29669853	+	EMID1	chr22	29650191	+	2.68E-05	0.9999732
EWSR1	chr22	29674205	+	EMID1	chr22	29639433	+	1.73E-09	1
EWSR1	chr22	29674205	+	EMID1	chr22	29639433	+	1.73E-09	1
EWSR1	chr22	29674205	+	EMID1	chr22	29650191	+	3.89E-10	1
EWSR1	chr22	29674205	+	EMID1	chr22	29654805	+	5.57E-09	1
EWSR1	chr22	29669853	+	EMID1	chr22	29650191	+	2.68E-05	0.9999732
EWSR1	chr22	29669853	+	EMID1	chr22	29650191	+	2.68E-05	0.9999732
EWSR1	chr22	29674205	+	EMID1	chr22	29639433	+	1.73E-09	1
EWSR1	chr22	29674205	+	EMID1	chr22	29639433	+	1.73E-09	1
EWSR1	chr22	29674205	+	EMID1	chr22	29650191	+	3.89E-10	1
EWSR1	chr22	29674205	+	EMID1	chr22	29654805	+	5.57E-09	1

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for EWSR1-EMID1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:29669853/:29650191)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
EWSR1 Q01844	EMID1 Q96A84
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for EWSR1-EMID1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for EWSR1-EMID1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for EWSR1-EMID1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for EWSR1-EMID1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source