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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:EWSR1-FEV (FusionGDB2 ID:27832) |
Fusion Gene Summary for EWSR1-FEV |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: EWSR1-FEV | Fusion gene ID: 27832 | Hgene | Tgene | Gene symbol | EWSR1 | FEV | Gene ID | 2130 | 54738 |
| Gene name | EWS RNA binding protein 1 | FEV transcription factor, ETS family member | |
| Synonyms | EWS|EWS-FLI1|bK984G1.4 | HSRNAFEV|PET-1 | |
| Cytomap | 22q12.2 | 2q35 | |
| Type of gene | protein-coding | protein-coding | |
| Description | RNA-binding protein EWSEWS RNA-binding protein variant 6Ewing sarcoma breakpoint region 1Ewings sarcoma EWS-Fli1 (type 1) oncogene | protein FEVFEV (ETS oncogene family)FEV, ETS transcription factorPC12 ETS domain-containing transcription factor 1fifth Ewing variant protein | |
| Modification date | 20200329 | 20200313 | |
| UniProtAcc | Q01844 | Q99581 | |
| Ensembl transtripts involved in fusion gene | ENST00000331029, ENST00000332050, ENST00000333395, ENST00000397938, ENST00000406548, ENST00000414183, ENST00000332035, | ENST00000295727, | |
| Fusion gene scores | * DoF score | 44 X 91 X 16=64064 | 3 X 2 X 2=12 |
| # samples | 98 | 2 | |
| ** MAII score | log2(98/64064*10)=-6.03058831983342 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/12*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: EWSR1 [Title/Abstract] AND FEV [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | |||
| Anticipated loss of major functional domain due to fusion event. | EWSR1-FEV seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. EWSR1-FEV seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. EWSR1-FEV seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. EWSR1-FEV seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene breakpoints across EWSR1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across FEV (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerKB3 | . | . | EWSR1 | chr22 | 29678546 | + | FEV | chr2 | 219849027 | - |
| ChimerKB3 | . | . | EWSR1 | chr22 | 29687588 | + | FEV | chr2 | 219849027 | - |
| ChimerKB4 | . | . | EWSR1 | chr22 | 29678546 | + | FEV | chr2 | 219849027 | - |
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Fusion Gene ORF analysis for EWSR1-FEV |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000331029 | ENST00000295727 | EWSR1 | chr22 | 29678546 | + | FEV | chr2 | 219849027 | - |
| Frame-shift | ENST00000332050 | ENST00000295727 | EWSR1 | chr22 | 29678546 | + | FEV | chr2 | 219849027 | - |
| Frame-shift | ENST00000333395 | ENST00000295727 | EWSR1 | chr22 | 29678546 | + | FEV | chr2 | 219849027 | - |
| Frame-shift | ENST00000397938 | ENST00000295727 | EWSR1 | chr22 | 29678546 | + | FEV | chr2 | 219849027 | - |
| Frame-shift | ENST00000406548 | ENST00000295727 | EWSR1 | chr22 | 29678546 | + | FEV | chr2 | 219849027 | - |
| Frame-shift | ENST00000414183 | ENST00000295727 | EWSR1 | chr22 | 29678546 | + | FEV | chr2 | 219849027 | - |
| In-frame | ENST00000332035 | ENST00000295727 | EWSR1 | chr22 | 29687588 | + | FEV | chr2 | 219849027 | - |
| In-frame | ENST00000397938 | ENST00000295727 | EWSR1 | chr22 | 29687588 | + | FEV | chr2 | 219849027 | - |
| In-frame | ENST00000406548 | ENST00000295727 | EWSR1 | chr22 | 29687588 | + | FEV | chr2 | 219849027 | - |
| In-frame | ENST00000414183 | ENST00000295727 | EWSR1 | chr22 | 29687588 | + | FEV | chr2 | 219849027 | - |
| intron-3CDS | ENST00000331029 | ENST00000295727 | EWSR1 | chr22 | 29687588 | + | FEV | chr2 | 219849027 | - |
| intron-3CDS | ENST00000332035 | ENST00000295727 | EWSR1 | chr22 | 29678546 | + | FEV | chr2 | 219849027 | - |
| intron-3CDS | ENST00000332050 | ENST00000295727 | EWSR1 | chr22 | 29687588 | + | FEV | chr2 | 219849027 | - |
| intron-3CDS | ENST00000333395 | ENST00000295727 | EWSR1 | chr22 | 29687588 | + | FEV | chr2 | 219849027 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000397938 | EWSR1 | chr22 | 29687588 | + | ENST00000295727 | FEV | chr2 | 219849027 | - | 2576 | 1331 | 319 | 1995 | 558 |
| ENST00000406548 | EWSR1 | chr22 | 29687588 | + | ENST00000295727 | FEV | chr2 | 219849027 | - | 2318 | 1073 | 64 | 1737 | 557 |
| ENST00000414183 | EWSR1 | chr22 | 29687588 | + | ENST00000295727 | FEV | chr2 | 219849027 | - | 2293 | 1048 | 21 | 1712 | 563 |
| ENST00000332035 | EWSR1 | chr22 | 29687588 | + | ENST00000295727 | FEV | chr2 | 219849027 | - | 2100 | 855 | 11 | 1519 | 502 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for EWSR1-FEV |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for EWSR1-FEV |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:/chr2:) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| EWSR1 | FEV |
| FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: Functions as a transcriptional regulator. According to PubMed:12761502, it functions as a transcriptional repressor. Functions in the differentiation and the maintenance of the central serotonergic neurons. May play a role in cell growth. {ECO:0000269|PubMed:12761502}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for EWSR1-FEV |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >27832_27832_1_EWSR1-FEV_EWSR1_chr22_29687588_ENST00000332035_FEV_chr2_219849027_ENST00000295727_length(transcript)=2100nt_BP=855nt AAGGAGAGAAAATGGCGTCCACGGATTACAGTACCTATAGCCAAGCTGCAGCGCAGCAGGGCTACAGTGCTTACACCGCCCAGCCCACTC AAGGATATGCACAGACCACCCAGGCATATGGGCAACAAAGCTATGGAACCTATGGACAGCCCACTGATGTCAGCTATACCCAGGCTCAGA CCACTGCAACCTATGGGCAGACCGCCTATGCAACTTCTTATGGACAGCCTCCCACTGGTTATACTACTCCAACTGCCCCCCAGGCATACA GCCAGCCTGTCCAGGGGTATGGCACTGGTGCTTATGATACCACCACTGCTACAGTCACCACCACCCAGGCCTCCTATGCAGCTCAGTCTG CATATGGCACTCAGCCTGCTTATCCAGCCTATGGGCAGCAGCCAGCAGCCACTGCACCTACAAGCTATTCCTCTACACAGCCGACTAGTT ATGATCAGAGCAGTTACTCTCAGCAGAACACCTATGGGCAACCGAGCAGCTATGGACAGCAGAGTAGCTATGGTCAACAAAGCAGCTATG GGCAGCAGCCTCCCACTAGTTACCCACCCCAAACTGGATCCTACAGCCAAGCTCCAAGTCAATATAGCCAACAGAGCAGCAGCTACGGGC AGCAGAGTTCATTCCGACAGGACCACCCCAGTAGCATGGGTGTTTATGGGCAGGAGTCTGGAGGATTTTCCGGACCAGGAGAGAACCGGA GCATGAGTGGCCCTGATAACCGGGGCAGGGGAAGAGGGGGATTTGATCGTGGAGGCATGAGCAGAGGTGGGCGGGGAGGAGGACGCGGTG GAATGGGCAGCGCTGGAGAGCGAGGTGGCTTCAATAAGCCTGGTGATCCCGTCGGAGACGGTCTCTTCAAGGACGGGAAGAACCCGAGCT GGGGGCCGCTGAGCCCCGCGGTTCAGAAAGGCAGCGGACAGATCCAGCTGTGGCAGTTTCTGCTGGAGCTGCTGGCTGACCGCGCGAACG CCGGCTGCATCGCGTGGGAGGGCGGTCACGGCGAGTTCAAGCTCACGGACCCGGACGAGGTGGCGCGGCGGTGGGGCGAGCGCAAGAGCA AGCCCAACATGAACTACGACAAGCTGAGCCGCGCCCTGCGCTACTACTACGACAAGAACATCATGAGCAAGGTGCATGGCAAGCGCTACG CCTACCGCTTCGACTTCCAGGGCCTGGCGCAGGCCTGCCAGCCGCCGCCCGCGCACGCTCATGCCGCCGCCGCAGCTGCTGCCGCCGCCG CGGCCGCCCAGGACGGCGCGCTCTACAAGCTGCCCGCCGGCCTCGCCCCGCTGCCCTTCCCCGGCCTCTCCAAACTCAACCTCATGGCCG CCTCGGCCGGGGTCGCGCCCGCCGGCTTCTCCTACTGGCCGGGCCCGGGCCCCGCCGCCACCGCTGCCGCCGCCACCGCCGCGCTCTACC CCAGTCCCAGCTTGCAGCCCCCGCCCGGGCCCTTCGGGGCCGTGGCCGCAGCCTCGCACTTGGGGGGCCATTACCACTAGACGGGGCGGT CGGGTGCCTGCGGCCTCGCCCGCACGCCTAGAGTCTCGCCCGATCCCATCGGCATCCCGGGGAGGGCCCGGGAGCCTCCGTCAACCGTCC TCTAATCCAGAGTTTACTCCACCTGCCGCACTTAGCAGGGGGACGGGACCGAAGCTCCCTCAATCCTTGTCTGGTACTAGATTTGCTCCT GTCCCACCCCGCAGTCCCCTGAGGAGGGCGATGTGCGCCCTCTTTCACTTTTTTTCTTCTAGGTCTCCAGGTCCCGGAGGGGATTTGTGG ACCTCTCTTGTCTCCCCACCACTCCAGTGCATTTCCGCCTGGCTCCTAGAAGCCCCATTCAATATCACTACTCTTTAACGAGTGCCAAAT CTTTTCCCACTTTTGCTCTTCCCCAAGGAACTGCTCCCACCTCAGCACGTGGAGGCCTCTCACGGTCCTCCTTCCTGGGACCTGAGCAGG TTTGGTGAAAGCCACCGTCCTCCGTGACACACGGCCCCCTTCCTCCTGTCCCCACACTCCCAGGAGAAACTCCCGGTGTGTTTCTGACCC >27832_27832_1_EWSR1-FEV_EWSR1_chr22_29687588_ENST00000332035_FEV_chr2_219849027_ENST00000295727_length(amino acids)=502AA_BP=281 MASTDYSTYSQAAAQQGYSAYTAQPTQGYAQTTQAYGQQSYGTYGQPTDVSYTQAQTTATYGQTAYATSYGQPPTGYTTPTAPQAYSQPV QGYGTGAYDTTTATVTTTQASYAAQSAYGTQPAYPAYGQQPAATAPTSYSSTQPTSYDQSSYSQQNTYGQPSSYGQQSSYGQQSSYGQQP PTSYPPQTGSYSQAPSQYSQQSSSYGQQSSFRQDHPSSMGVYGQESGGFSGPGENRSMSGPDNRGRGRGGFDRGGMSRGGRGGGRGGMGS AGERGGFNKPGDPVGDGLFKDGKNPSWGPLSPAVQKGSGQIQLWQFLLELLADRANAGCIAWEGGHGEFKLTDPDEVARRWGERKSKPNM NYDKLSRALRYYYDKNIMSKVHGKRYAYRFDFQGLAQACQPPPAHAHAAAAAAAAAAAAQDGALYKLPAGLAPLPFPGLSKLNLMAASAG -------------------------------------------------------------- >27832_27832_2_EWSR1-FEV_EWSR1_chr22_29687588_ENST00000397938_FEV_chr2_219849027_ENST00000295727_length(transcript)=2576nt_BP=1331nt GGACGGAACCATTCCAAACAGCCTAGTCTCGTGCTGAGAGCCTCTCCGGTTTCACGCTGAGACCCGCTCACCCCCGCTCTGGCCCCTTAG ATGCTATTTTGGCCCGAGTGTCACGTCGGGCGCTCTTTAGAGAGGACTGGGACAAGAGTTGCGGACGCGAAGAACGAGTAAGCGGTGGTT CATCCCTCCTGACCCCACCCCCGTGGCCTGGCCCGATGGTCGCGCCCGGGGTTGCGAGATTTGCGCCTGCGCAGTGCGGCGCCTAGAGGG AAAGCGAGAGGGAGACGGACGTTGAGAGAACGAGGAGGAAGGAGAGAAAATGGCGTCCACGGATTACAGTACCTATAGCCAAGCTGCAGC GCAGCAGGGCTACAGTGCTTACACCGCCCAGCCCACTCAAGGATATGCACAGACCACCCAGGCATATGGGCAACAAAGCTATGGAACCTA TGGACAGCCCACTGATGTCAGCTATACCCAGGCTCAGACCACTGCAACCTATGGGCAGACCGCCTATGCAACTTCTTATGGACAGCCTCC CACTGGTTATACTACTCCAACTGCCCCCCAGGCATACAGCCAGCCTGTCCAGGGGTATGGCACTGGTGCTTATGATACCACCACTGCTAC AGTCACCACCACCCAGGCCTCCTATGCAGCTCAGTCTGCATATGGCACTCAGCCTGCTTATCCAGCCTATGGGCAGCAGCCAGCAGCCAC TGCACCTACAAGACCGCAGGATGGAAACAAGCCCACTGAGACTAGTCAACCTCAATCTAGCACAGGGGGTTACAACCAGCCCAGCCTAGG ATATGGACAGAGTAACTACAGTTATCCCCAGGTACCTGGGAGCTACCCCATGCAGCCAGTCACTGCACCTCCATCCTACCCTCCTACCAG CTATTCCTCTACACAGCCGACTAGTTATGATCAGAGCAGTTACTCTCAGCAGAACACCTATGGGCAACCGAGCAGCTATGGACAGCAGAG TAGCTATGGTCAACAAAGCAGCTATGGGCAGCAGCCTCCCACTAGTTACCCACCCCAAACTGGATCCTACAGCCAAGCTCCAAGTCAATA TAGCCAACAGAGCAGCAGCTACGGGCAGCAGAGTTCATTCCGACAGGACCACCCCAGTAGCATGGGTGTTTATGGGCAGGAGTCTGGAGG ATTTTCCGGACCAGGAGAGAACCGGAGCATGAGTGGCCCTGATAACCGGGGCAGGGGAAGAGGGGGATTTGATCGTGGAGGCATGAGCAG AGGTGGGCGGGGAGGAGGACGCGGTGGAATGGGCAGCGCTGGAGAGCGAGGTGGCTTCAATAAGCCTGGTGATCCCGTCGGAGACGGTCT CTTCAAGGACGGGAAGAACCCGAGCTGGGGGCCGCTGAGCCCCGCGGTTCAGAAAGGCAGCGGACAGATCCAGCTGTGGCAGTTTCTGCT GGAGCTGCTGGCTGACCGCGCGAACGCCGGCTGCATCGCGTGGGAGGGCGGTCACGGCGAGTTCAAGCTCACGGACCCGGACGAGGTGGC GCGGCGGTGGGGCGAGCGCAAGAGCAAGCCCAACATGAACTACGACAAGCTGAGCCGCGCCCTGCGCTACTACTACGACAAGAACATCAT GAGCAAGGTGCATGGCAAGCGCTACGCCTACCGCTTCGACTTCCAGGGCCTGGCGCAGGCCTGCCAGCCGCCGCCCGCGCACGCTCATGC CGCCGCCGCAGCTGCTGCCGCCGCCGCGGCCGCCCAGGACGGCGCGCTCTACAAGCTGCCCGCCGGCCTCGCCCCGCTGCCCTTCCCCGG CCTCTCCAAACTCAACCTCATGGCCGCCTCGGCCGGGGTCGCGCCCGCCGGCTTCTCCTACTGGCCGGGCCCGGGCCCCGCCGCCACCGC TGCCGCCGCCACCGCCGCGCTCTACCCCAGTCCCAGCTTGCAGCCCCCGCCCGGGCCCTTCGGGGCCGTGGCCGCAGCCTCGCACTTGGG GGGCCATTACCACTAGACGGGGCGGTCGGGTGCCTGCGGCCTCGCCCGCACGCCTAGAGTCTCGCCCGATCCCATCGGCATCCCGGGGAG GGCCCGGGAGCCTCCGTCAACCGTCCTCTAATCCAGAGTTTACTCCACCTGCCGCACTTAGCAGGGGGACGGGACCGAAGCTCCCTCAAT CCTTGTCTGGTACTAGATTTGCTCCTGTCCCACCCCGCAGTCCCCTGAGGAGGGCGATGTGCGCCCTCTTTCACTTTTTTTCTTCTAGGT CTCCAGGTCCCGGAGGGGATTTGTGGACCTCTCTTGTCTCCCCACCACTCCAGTGCATTTCCGCCTGGCTCCTAGAAGCCCCATTCAATA TCACTACTCTTTAACGAGTGCCAAATCTTTTCCCACTTTTGCTCTTCCCCAAGGAACTGCTCCCACCTCAGCACGTGGAGGCCTCTCACG GTCCTCCTTCCTGGGACCTGAGCAGGTTTGGTGAAAGCCACCGTCCTCCGTGACACACGGCCCCCTTCCTCCTGTCCCCACACTCCCAGG >27832_27832_2_EWSR1-FEV_EWSR1_chr22_29687588_ENST00000397938_FEV_chr2_219849027_ENST00000295727_length(amino acids)=558AA_BP=337 MASTDYSTYSQAAAQQGYSAYTAQPTQGYAQTTQAYGQQSYGTYGQPTDVSYTQAQTTATYGQTAYATSYGQPPTGYTTPTAPQAYSQPV QGYGTGAYDTTTATVTTTQASYAAQSAYGTQPAYPAYGQQPAATAPTRPQDGNKPTETSQPQSSTGGYNQPSLGYGQSNYSYPQVPGSYP MQPVTAPPSYPPTSYSSTQPTSYDQSSYSQQNTYGQPSSYGQQSSYGQQSSYGQQPPTSYPPQTGSYSQAPSQYSQQSSSYGQQSSFRQD HPSSMGVYGQESGGFSGPGENRSMSGPDNRGRGRGGFDRGGMSRGGRGGGRGGMGSAGERGGFNKPGDPVGDGLFKDGKNPSWGPLSPAV QKGSGQIQLWQFLLELLADRANAGCIAWEGGHGEFKLTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMSKVHGKRYAYRFDFQG LAQACQPPPAHAHAAAAAAAAAAAAQDGALYKLPAGLAPLPFPGLSKLNLMAASAGVAPAGFSYWPGPGPAATAAAATAALYPSPSLQPP -------------------------------------------------------------- >27832_27832_3_EWSR1-FEV_EWSR1_chr22_29687588_ENST00000406548_FEV_chr2_219849027_ENST00000295727_length(transcript)=2318nt_BP=1073nt GCGGCGCCTAGAGGGAAAGCGAGAGGGAGACGGACGTTGAGAGAACGAGGAGGAAGGAGAGAAAATGGCGTCCACGGATTACAGTACCTA TAGCCAAGCTGCAGCGCAGCAGGGCTACAGTGCTTACACCGCCCAGCCCACTCAAGGATATGCACAGACCACCCAGGCATATGGGCAACA AAGCTATGGAACCTATGGACAGCCCACTGATGTCAGCTATACCCAGGCTCAGACCACTGCAACCTATGGGCAGACCGCCTATGCAACTTC TTATGGACAGCCTCCCACTGGTTATACTACTCCAACTGCCCCCCAGGCATACAGCCAGCCTGTCCAGGGGTATGGCACTGGTGCTTATGA TACCACCACTGCTACAGTCACCACCACCCAGGCCTCCTATGCAGCTCAGTCTGCATATGGCACTCAGCCTGCTTATCCAGCCTATGGGCA GCAGCCAGCAGCCACTGCACCTACAAGACCGCAGGATGGAAACAAGCCCACTGAGACTAGTCAACCTCAATCTAGCACAGGGGGTTACAA CCAGCCCAGCCTAGGATATGGACAGAGTAACTACAGTTATCCCCAGGTACCTGGGAGCTACCCCATGCAGCCAGTCACTGCACCTCCATC CTACCCTCCTACCAGCTATTCCTCTACACAGCCGACTAGTTATGATCAGAGCAGTTACTCTCAGCAGAACACCTATGGGCAACCGAGCAG CTATGGACAGCAGAGTAGCTATGGTCAACAAAGCAGCTATGGGCAGCAGCCTCCCACTAGTTACCCACCCCAAACTGGATCCTACAGCCA AGCTCCAAGTCAATATAGCCAACAGAGCAGCAGCTACGGGCAGCAGAGTTCATTCCGACAGGACCACCCCAGTAGCATGGGTGTTTATGG GCAGGAGTCTGGAGGATTTTCCGGACCAGGAGAGAACCGGAGCATGAGTGGCCCTGATAACCGGGGCAGGGGAAGAGGGGGATTTGATCG TGGAGGCATGAGCAGAGGTGGGCGGGGAGGAGGACGCGGTGGAATGGGCGCTGGAGAGCGAGGTGGCTTCAATAAGCCTGGTGATCCCGT CGGAGACGGTCTCTTCAAGGACGGGAAGAACCCGAGCTGGGGGCCGCTGAGCCCCGCGGTTCAGAAAGGCAGCGGACAGATCCAGCTGTG GCAGTTTCTGCTGGAGCTGCTGGCTGACCGCGCGAACGCCGGCTGCATCGCGTGGGAGGGCGGTCACGGCGAGTTCAAGCTCACGGACCC GGACGAGGTGGCGCGGCGGTGGGGCGAGCGCAAGAGCAAGCCCAACATGAACTACGACAAGCTGAGCCGCGCCCTGCGCTACTACTACGA CAAGAACATCATGAGCAAGGTGCATGGCAAGCGCTACGCCTACCGCTTCGACTTCCAGGGCCTGGCGCAGGCCTGCCAGCCGCCGCCCGC GCACGCTCATGCCGCCGCCGCAGCTGCTGCCGCCGCCGCGGCCGCCCAGGACGGCGCGCTCTACAAGCTGCCCGCCGGCCTCGCCCCGCT GCCCTTCCCCGGCCTCTCCAAACTCAACCTCATGGCCGCCTCGGCCGGGGTCGCGCCCGCCGGCTTCTCCTACTGGCCGGGCCCGGGCCC CGCCGCCACCGCTGCCGCCGCCACCGCCGCGCTCTACCCCAGTCCCAGCTTGCAGCCCCCGCCCGGGCCCTTCGGGGCCGTGGCCGCAGC CTCGCACTTGGGGGGCCATTACCACTAGACGGGGCGGTCGGGTGCCTGCGGCCTCGCCCGCACGCCTAGAGTCTCGCCCGATCCCATCGG CATCCCGGGGAGGGCCCGGGAGCCTCCGTCAACCGTCCTCTAATCCAGAGTTTACTCCACCTGCCGCACTTAGCAGGGGGACGGGACCGA AGCTCCCTCAATCCTTGTCTGGTACTAGATTTGCTCCTGTCCCACCCCGCAGTCCCCTGAGGAGGGCGATGTGCGCCCTCTTTCACTTTT TTTCTTCTAGGTCTCCAGGTCCCGGAGGGGATTTGTGGACCTCTCTTGTCTCCCCACCACTCCAGTGCATTTCCGCCTGGCTCCTAGAAG CCCCATTCAATATCACTACTCTTTAACGAGTGCCAAATCTTTTCCCACTTTTGCTCTTCCCCAAGGAACTGCTCCCACCTCAGCACGTGG AGGCCTCTCACGGTCCTCCTTCCTGGGACCTGAGCAGGTTTGGTGAAAGCCACCGTCCTCCGTGACACACGGCCCCCTTCCTCCTGTCCC >27832_27832_3_EWSR1-FEV_EWSR1_chr22_29687588_ENST00000406548_FEV_chr2_219849027_ENST00000295727_length(amino acids)=557AA_BP=336 MASTDYSTYSQAAAQQGYSAYTAQPTQGYAQTTQAYGQQSYGTYGQPTDVSYTQAQTTATYGQTAYATSYGQPPTGYTTPTAPQAYSQPV QGYGTGAYDTTTATVTTTQASYAAQSAYGTQPAYPAYGQQPAATAPTRPQDGNKPTETSQPQSSTGGYNQPSLGYGQSNYSYPQVPGSYP MQPVTAPPSYPPTSYSSTQPTSYDQSSYSQQNTYGQPSSYGQQSSYGQQSSYGQQPPTSYPPQTGSYSQAPSQYSQQSSSYGQQSSFRQD HPSSMGVYGQESGGFSGPGENRSMSGPDNRGRGRGGFDRGGMSRGGRGGGRGGMGAGERGGFNKPGDPVGDGLFKDGKNPSWGPLSPAVQ KGSGQIQLWQFLLELLADRANAGCIAWEGGHGEFKLTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMSKVHGKRYAYRFDFQGL AQACQPPPAHAHAAAAAAAAAAAAQDGALYKLPAGLAPLPFPGLSKLNLMAASAGVAPAGFSYWPGPGPAATAAAATAALYPSPSLQPPP -------------------------------------------------------------- >27832_27832_4_EWSR1-FEV_EWSR1_chr22_29687588_ENST00000414183_FEV_chr2_219849027_ENST00000295727_length(transcript)=2293nt_BP=1048nt AACGAGGAGGAAGGAGAGAAAATGGCGTCCACGGATTACAGTACCTATAGCCAAGCTGCAGCGCAGCAGGGCTACAGTGCTTACACCGCC CAGCCCACTCAAGGATATGCACAGACCACCCAGGCATATGGGCAACAAAGCTATGGAACCTATGGACAGCCCACTGATGTCAGCTATACC CAGGCTCAGACCACTGCAACCTATGGGCAGACCGCCTATGCAACTTCTTATGGACAGCCTCCCACTGTAGAAGGGACCAGTACAGGTTAT ACTACTCCAACTGCCCCCCAGGCATACAGCCAGCCTGTCCAGGGGTATGGCACTGGTGCTTATGATACCACCACTGCTACAGTCACCACC ACCCAGGCCTCCTATGCAGCTCAGTCTGCATATGGCACTCAGCCTGCTTATCCAGCCTATGGGCAGCAGCCAGCAGCCACTGCACCTACA AGACCGCAGGATGGAAACAAGCCCACTGAGACTAGTCAACCTCAATCTAGCACAGGGGGTTACAACCAGCCCAGCCTAGGATATGGACAG AGTAACTACAGTTATCCCCAGGTACCTGGGAGCTACCCCATGCAGCCAGTCACTGCACCTCCATCCTACCCTCCTACCAGCTATTCCTCT ACACAGCCGACTAGTTATGATCAGAGCAGTTACTCTCAGCAGAACACCTATGGGCAACCGAGCAGCTATGGACAGCAGAGTAGCTATGGT CAACAAAGCAGCTATGGGCAGCAGCCTCCCACTAGTTACCCACCCCAAACTGGATCCTACAGCCAAGCTCCAAGTCAATATAGCCAACAG AGCAGCAGCTACGGGCAGCAGAGTTCATTCCGACAGGACCACCCCAGTAGCATGGGTGTTTATGGGCAGGAGTCTGGAGGATTTTCCGGA CCAGGAGAGAACCGGAGCATGAGTGGCCCTGATAACCGGGGCAGGGGAAGAGGGGGATTTGATCGTGGAGGCATGAGCAGAGGTGGGCGG GGAGGAGGACGCGGTGGAATGGGCGCTGGAGAGCGAGGTGGCTTCAATAAGCCTGGTGATCCCGTCGGAGACGGTCTCTTCAAGGACGGG AAGAACCCGAGCTGGGGGCCGCTGAGCCCCGCGGTTCAGAAAGGCAGCGGACAGATCCAGCTGTGGCAGTTTCTGCTGGAGCTGCTGGCT GACCGCGCGAACGCCGGCTGCATCGCGTGGGAGGGCGGTCACGGCGAGTTCAAGCTCACGGACCCGGACGAGGTGGCGCGGCGGTGGGGC GAGCGCAAGAGCAAGCCCAACATGAACTACGACAAGCTGAGCCGCGCCCTGCGCTACTACTACGACAAGAACATCATGAGCAAGGTGCAT GGCAAGCGCTACGCCTACCGCTTCGACTTCCAGGGCCTGGCGCAGGCCTGCCAGCCGCCGCCCGCGCACGCTCATGCCGCCGCCGCAGCT GCTGCCGCCGCCGCGGCCGCCCAGGACGGCGCGCTCTACAAGCTGCCCGCCGGCCTCGCCCCGCTGCCCTTCCCCGGCCTCTCCAAACTC AACCTCATGGCCGCCTCGGCCGGGGTCGCGCCCGCCGGCTTCTCCTACTGGCCGGGCCCGGGCCCCGCCGCCACCGCTGCCGCCGCCACC GCCGCGCTCTACCCCAGTCCCAGCTTGCAGCCCCCGCCCGGGCCCTTCGGGGCCGTGGCCGCAGCCTCGCACTTGGGGGGCCATTACCAC TAGACGGGGCGGTCGGGTGCCTGCGGCCTCGCCCGCACGCCTAGAGTCTCGCCCGATCCCATCGGCATCCCGGGGAGGGCCCGGGAGCCT CCGTCAACCGTCCTCTAATCCAGAGTTTACTCCACCTGCCGCACTTAGCAGGGGGACGGGACCGAAGCTCCCTCAATCCTTGTCTGGTAC TAGATTTGCTCCTGTCCCACCCCGCAGTCCCCTGAGGAGGGCGATGTGCGCCCTCTTTCACTTTTTTTCTTCTAGGTCTCCAGGTCCCGG AGGGGATTTGTGGACCTCTCTTGTCTCCCCACCACTCCAGTGCATTTCCGCCTGGCTCCTAGAAGCCCCATTCAATATCACTACTCTTTA ACGAGTGCCAAATCTTTTCCCACTTTTGCTCTTCCCCAAGGAACTGCTCCCACCTCAGCACGTGGAGGCCTCTCACGGTCCTCCTTCCTG GGACCTGAGCAGGTTTGGTGAAAGCCACCGTCCTCCGTGACACACGGCCCCCTTCCTCCTGTCCCCACACTCCCAGGAGAAACTCCCGGT >27832_27832_4_EWSR1-FEV_EWSR1_chr22_29687588_ENST00000414183_FEV_chr2_219849027_ENST00000295727_length(amino acids)=563AA_BP=342 MASTDYSTYSQAAAQQGYSAYTAQPTQGYAQTTQAYGQQSYGTYGQPTDVSYTQAQTTATYGQTAYATSYGQPPTVEGTSTGYTTPTAPQ AYSQPVQGYGTGAYDTTTATVTTTQASYAAQSAYGTQPAYPAYGQQPAATAPTRPQDGNKPTETSQPQSSTGGYNQPSLGYGQSNYSYPQ VPGSYPMQPVTAPPSYPPTSYSSTQPTSYDQSSYSQQNTYGQPSSYGQQSSYGQQSSYGQQPPTSYPPQTGSYSQAPSQYSQQSSSYGQQ SSFRQDHPSSMGVYGQESGGFSGPGENRSMSGPDNRGRGRGGFDRGGMSRGGRGGGRGGMGAGERGGFNKPGDPVGDGLFKDGKNPSWGP LSPAVQKGSGQIQLWQFLLELLADRANAGCIAWEGGHGEFKLTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMSKVHGKRYAYR FDFQGLAQACQPPPAHAHAAAAAAAAAAAAQDGALYKLPAGLAPLPFPGLSKLNLMAASAGVAPAGFSYWPGPGPAATAAAATAALYPSP -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for EWSR1-FEV |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for EWSR1-FEV |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for EWSR1-FEV |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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