Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:EWSR1-NR4A3 (FusionGDB2 ID:27847)

Fusion Gene Summary for EWSR1-NR4A3

Fusion gene summary

Fusion gene information	Fusion gene name: EWSR1-NR4A3
	Fusion gene ID: 27847
		Hgene	Tgene
	Gene symbol	EWSR1	NR4A3
	Gene ID	2130	8013
	Gene name	EWS RNA binding protein 1	nuclear receptor subfamily 4 group A member 3
	Synonyms	EWS\|EWS-FLI1\|bK984G1.4	CHN\|CSMF\|MINOR\|NOR1\|TEC
	Cytomap	22q12.2	9q31.1
	Type of gene	protein-coding	protein-coding
	Description	RNA-binding protein EWSEWS RNA-binding protein variant 6Ewing sarcoma breakpoint region 1Ewings sarcoma EWS-Fli1 (type 1) oncogene	nuclear receptor subfamily 4 group A member 3chondrosarcoma, extraskeletal myxoid, fused to EWSmitogen-induced nuclear orphan receptorneuron-derived orphan receptor 1nuclear hormone receptor NOR-1translocated in extraskeletal chondrosarcoma
	Modification date	20200329	20200313
	UniProtAcc	Q01844	Q92570
	Ensembl transtripts involved in fusion gene	ENST00000331029, ENST00000332035, ENST00000332050, ENST00000333395, ENST00000397938, ENST00000406548, ENST00000414183,	ENST00000338488, ENST00000395097, ENST00000330847,
Fusion gene scores	* DoF score	44 X 91 X 16=64064	9 X 11 X 7=693
	# samples	98	11
	** MAII score	log2(98/64064*10)=-6.03058831983342 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(11/693*10)=-2.65535182861255 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: EWSR1 [Title/Abstract] AND NR4A3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	EWSR1(29688159)-NR4A3(102589010), # samples:2
Anticipated loss of major functional domain due to fusion event.	EWSR1-NR4A3 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. EWSR1-NR4A3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. EWSR1-NR4A3 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. EWSR1-NR4A3 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. EWSR1-NR4A3 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF. EWSR1-NR4A3 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF. NR4A3-EWSR1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. NR4A3-EWSR1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. NR4A3-EWSR1 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF. NR4A3-EWSR1 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF. NR4A3-EWSR1 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. NR4A3-EWSR1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	NR4A3	GO:0010828	positive regulation of glucose transmembrane transport	24022864
Tgene	NR4A3	GO:0045944	positive regulation of transcription by RNA polymerase II	20558821
Tgene	NR4A3	GO:0048008	platelet-derived growth factor receptor signaling pathway	23554459
Tgene	NR4A3	GO:0048660	regulation of smooth muscle cell proliferation	25852083

Fusion gene breakpoints across EWSR1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across NR4A3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	chomdrosarcoma	AF524261	EWSR1	chr22	29688159		NR4A3	chr9	102589010
ChimerKB3	.	.	EWSR1	chr22	29683123	+	NR4A3	chr9	102587941	+
ChimerKB3	.	.	EWSR1	chr22	29688159	+	NR4A3	chr9	102589010	+
ChimerKB3	.	.	EWSR1	chr22	29688595	+	NR4A3	chr9	102591275	+
ChimerKB3	.	.	EWSR1	chr22	29692358	+	NR4A3	chr9	102594970	+
ChimerKB4	.	.	EWSR1	chr22	29692358	+	NR4A3	chr9	102594970	+
ChiTaRS5.0	N/A	AF524261	EWSR1	chr22	29688159	+	NR4A3	chr9	102589010	+
ChiTaRS5.0	N/A	S81242	EWSR1	chr22	29683123	+	NR4A3	chr9	102587941	+

Top

Fusion Gene ORF analysis for EWSR1-NR4A3

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000331029	ENST00000338488	EWSR1	chr22	29683123	+	NR4A3	chr9	102587941	+
5CDS-5UTR	ENST00000331029	ENST00000395097	EWSR1	chr22	29683123	+	NR4A3	chr9	102587941	+
5CDS-5UTR	ENST00000332035	ENST00000338488	EWSR1	chr22	29683123	+	NR4A3	chr9	102587941	+
5CDS-5UTR	ENST00000332035	ENST00000395097	EWSR1	chr22	29683123	+	NR4A3	chr9	102587941	+
5CDS-5UTR	ENST00000332050	ENST00000338488	EWSR1	chr22	29683123	+	NR4A3	chr9	102587941	+
5CDS-5UTR	ENST00000332050	ENST00000395097	EWSR1	chr22	29683123	+	NR4A3	chr9	102587941	+
5CDS-5UTR	ENST00000333395	ENST00000338488	EWSR1	chr22	29683123	+	NR4A3	chr9	102587941	+
5CDS-5UTR	ENST00000333395	ENST00000395097	EWSR1	chr22	29683123	+	NR4A3	chr9	102587941	+
5CDS-5UTR	ENST00000397938	ENST00000338488	EWSR1	chr22	29683123	+	NR4A3	chr9	102587941	+
5CDS-5UTR	ENST00000397938	ENST00000395097	EWSR1	chr22	29683123	+	NR4A3	chr9	102587941	+
5CDS-5UTR	ENST00000406548	ENST00000338488	EWSR1	chr22	29683123	+	NR4A3	chr9	102587941	+
5CDS-5UTR	ENST00000406548	ENST00000395097	EWSR1	chr22	29683123	+	NR4A3	chr9	102587941	+
5CDS-5UTR	ENST00000414183	ENST00000338488	EWSR1	chr22	29683123	+	NR4A3	chr9	102587941	+
5CDS-5UTR	ENST00000414183	ENST00000395097	EWSR1	chr22	29683123	+	NR4A3	chr9	102587941	+
5CDS-intron	ENST00000331029	ENST00000330847	EWSR1	chr22	29683123	+	NR4A3	chr9	102587941	+
5CDS-intron	ENST00000331029	ENST00000330847	EWSR1	chr22	29688595	+	NR4A3	chr9	102591275	+
5CDS-intron	ENST00000331029	ENST00000338488	EWSR1	chr22	29688595	+	NR4A3	chr9	102591275	+
5CDS-intron	ENST00000331029	ENST00000395097	EWSR1	chr22	29688595	+	NR4A3	chr9	102591275	+
5CDS-intron	ENST00000332035	ENST00000330847	EWSR1	chr22	29688159		NR4A3	chr9	102589010
5CDS-intron	ENST00000332035	ENST00000330847	EWSR1	chr22	29683123	+	NR4A3	chr9	102587941	+
5CDS-intron	ENST00000332035	ENST00000330847	EWSR1	chr22	29688159	+	NR4A3	chr9	102589010	+
5CDS-intron	ENST00000332035	ENST00000330847	EWSR1	chr22	29688595	+	NR4A3	chr9	102591275	+
5CDS-intron	ENST00000332035	ENST00000338488	EWSR1	chr22	29688159		NR4A3	chr9	102589010
5CDS-intron	ENST00000332035	ENST00000338488	EWSR1	chr22	29688159	+	NR4A3	chr9	102589010	+
5CDS-intron	ENST00000332035	ENST00000338488	EWSR1	chr22	29688595	+	NR4A3	chr9	102591275	+
5CDS-intron	ENST00000332035	ENST00000395097	EWSR1	chr22	29688159		NR4A3	chr9	102589010
5CDS-intron	ENST00000332035	ENST00000395097	EWSR1	chr22	29688159	+	NR4A3	chr9	102589010	+
5CDS-intron	ENST00000332035	ENST00000395097	EWSR1	chr22	29688595	+	NR4A3	chr9	102591275	+
5CDS-intron	ENST00000332050	ENST00000330847	EWSR1	chr22	29688159		NR4A3	chr9	102589010
5CDS-intron	ENST00000332050	ENST00000330847	EWSR1	chr22	29683123	+	NR4A3	chr9	102587941	+
5CDS-intron	ENST00000332050	ENST00000330847	EWSR1	chr22	29688159	+	NR4A3	chr9	102589010	+
5CDS-intron	ENST00000332050	ENST00000330847	EWSR1	chr22	29688595	+	NR4A3	chr9	102591275	+
5CDS-intron	ENST00000332050	ENST00000338488	EWSR1	chr22	29688159		NR4A3	chr9	102589010
5CDS-intron	ENST00000332050	ENST00000338488	EWSR1	chr22	29688159	+	NR4A3	chr9	102589010	+
5CDS-intron	ENST00000332050	ENST00000338488	EWSR1	chr22	29688595	+	NR4A3	chr9	102591275	+
5CDS-intron	ENST00000332050	ENST00000395097	EWSR1	chr22	29688159		NR4A3	chr9	102589010
5CDS-intron	ENST00000332050	ENST00000395097	EWSR1	chr22	29688159	+	NR4A3	chr9	102589010	+
5CDS-intron	ENST00000332050	ENST00000395097	EWSR1	chr22	29688595	+	NR4A3	chr9	102591275	+
5CDS-intron	ENST00000333395	ENST00000330847	EWSR1	chr22	29683123	+	NR4A3	chr9	102587941	+
5CDS-intron	ENST00000397938	ENST00000330847	EWSR1	chr22	29688159		NR4A3	chr9	102589010
5CDS-intron	ENST00000397938	ENST00000330847	EWSR1	chr22	29683123	+	NR4A3	chr9	102587941	+
5CDS-intron	ENST00000397938	ENST00000330847	EWSR1	chr22	29688159	+	NR4A3	chr9	102589010	+
5CDS-intron	ENST00000397938	ENST00000330847	EWSR1	chr22	29688595	+	NR4A3	chr9	102591275	+
5CDS-intron	ENST00000397938	ENST00000338488	EWSR1	chr22	29688159		NR4A3	chr9	102589010
5CDS-intron	ENST00000397938	ENST00000338488	EWSR1	chr22	29688159	+	NR4A3	chr9	102589010	+
5CDS-intron	ENST00000397938	ENST00000338488	EWSR1	chr22	29688595	+	NR4A3	chr9	102591275	+
5CDS-intron	ENST00000397938	ENST00000395097	EWSR1	chr22	29688159		NR4A3	chr9	102589010
5CDS-intron	ENST00000397938	ENST00000395097	EWSR1	chr22	29688159	+	NR4A3	chr9	102589010	+
5CDS-intron	ENST00000397938	ENST00000395097	EWSR1	chr22	29688595	+	NR4A3	chr9	102591275	+
5CDS-intron	ENST00000406548	ENST00000330847	EWSR1	chr22	29688159		NR4A3	chr9	102589010
5CDS-intron	ENST00000406548	ENST00000330847	EWSR1	chr22	29683123	+	NR4A3	chr9	102587941	+
5CDS-intron	ENST00000406548	ENST00000330847	EWSR1	chr22	29688159	+	NR4A3	chr9	102589010	+
5CDS-intron	ENST00000406548	ENST00000330847	EWSR1	chr22	29688595	+	NR4A3	chr9	102591275	+
5CDS-intron	ENST00000406548	ENST00000338488	EWSR1	chr22	29688159		NR4A3	chr9	102589010
5CDS-intron	ENST00000406548	ENST00000338488	EWSR1	chr22	29688159	+	NR4A3	chr9	102589010	+
5CDS-intron	ENST00000406548	ENST00000338488	EWSR1	chr22	29688595	+	NR4A3	chr9	102591275	+
5CDS-intron	ENST00000406548	ENST00000395097	EWSR1	chr22	29688159		NR4A3	chr9	102589010
5CDS-intron	ENST00000406548	ENST00000395097	EWSR1	chr22	29688159	+	NR4A3	chr9	102589010	+
5CDS-intron	ENST00000406548	ENST00000395097	EWSR1	chr22	29688595	+	NR4A3	chr9	102591275	+
5CDS-intron	ENST00000414183	ENST00000330847	EWSR1	chr22	29688159		NR4A3	chr9	102589010
5CDS-intron	ENST00000414183	ENST00000330847	EWSR1	chr22	29683123	+	NR4A3	chr9	102587941	+
5CDS-intron	ENST00000414183	ENST00000330847	EWSR1	chr22	29688159	+	NR4A3	chr9	102589010	+
5CDS-intron	ENST00000414183	ENST00000330847	EWSR1	chr22	29688595	+	NR4A3	chr9	102591275	+
5CDS-intron	ENST00000414183	ENST00000338488	EWSR1	chr22	29688159		NR4A3	chr9	102589010
5CDS-intron	ENST00000414183	ENST00000338488	EWSR1	chr22	29688159	+	NR4A3	chr9	102589010	+
5CDS-intron	ENST00000414183	ENST00000338488	EWSR1	chr22	29688595	+	NR4A3	chr9	102591275	+
5CDS-intron	ENST00000414183	ENST00000395097	EWSR1	chr22	29688159		NR4A3	chr9	102589010
5CDS-intron	ENST00000414183	ENST00000395097	EWSR1	chr22	29688159	+	NR4A3	chr9	102589010	+
5CDS-intron	ENST00000414183	ENST00000395097	EWSR1	chr22	29688595	+	NR4A3	chr9	102591275	+
Frame-shift	ENST00000331029	ENST00000330847	EWSR1	chr22	29692358	+	NR4A3	chr9	102594970	+
Frame-shift	ENST00000331029	ENST00000338488	EWSR1	chr22	29692358	+	NR4A3	chr9	102594970	+
Frame-shift	ENST00000331029	ENST00000395097	EWSR1	chr22	29692358	+	NR4A3	chr9	102594970	+
Frame-shift	ENST00000332035	ENST00000330847	EWSR1	chr22	29692358	+	NR4A3	chr9	102594970	+
Frame-shift	ENST00000332035	ENST00000338488	EWSR1	chr22	29692358	+	NR4A3	chr9	102594970	+
Frame-shift	ENST00000332035	ENST00000395097	EWSR1	chr22	29692358	+	NR4A3	chr9	102594970	+
Frame-shift	ENST00000332050	ENST00000330847	EWSR1	chr22	29692358	+	NR4A3	chr9	102594970	+
Frame-shift	ENST00000332050	ENST00000338488	EWSR1	chr22	29692358	+	NR4A3	chr9	102594970	+
Frame-shift	ENST00000332050	ENST00000395097	EWSR1	chr22	29692358	+	NR4A3	chr9	102594970	+
Frame-shift	ENST00000397938	ENST00000330847	EWSR1	chr22	29692358	+	NR4A3	chr9	102594970	+
Frame-shift	ENST00000397938	ENST00000338488	EWSR1	chr22	29692358	+	NR4A3	chr9	102594970	+
Frame-shift	ENST00000397938	ENST00000395097	EWSR1	chr22	29692358	+	NR4A3	chr9	102594970	+
Frame-shift	ENST00000406548	ENST00000330847	EWSR1	chr22	29692358	+	NR4A3	chr9	102594970	+
Frame-shift	ENST00000406548	ENST00000338488	EWSR1	chr22	29692358	+	NR4A3	chr9	102594970	+
Frame-shift	ENST00000406548	ENST00000395097	EWSR1	chr22	29692358	+	NR4A3	chr9	102594970	+
Frame-shift	ENST00000414183	ENST00000330847	EWSR1	chr22	29692358	+	NR4A3	chr9	102594970	+
Frame-shift	ENST00000414183	ENST00000338488	EWSR1	chr22	29692358	+	NR4A3	chr9	102594970	+
Frame-shift	ENST00000414183	ENST00000395097	EWSR1	chr22	29692358	+	NR4A3	chr9	102594970	+
intron-3CDS	ENST00000333395	ENST00000330847	EWSR1	chr22	29692358	+	NR4A3	chr9	102594970	+
intron-3CDS	ENST00000333395	ENST00000338488	EWSR1	chr22	29692358	+	NR4A3	chr9	102594970	+
intron-3CDS	ENST00000333395	ENST00000395097	EWSR1	chr22	29692358	+	NR4A3	chr9	102594970	+
intron-intron	ENST00000331029	ENST00000330847	EWSR1	chr22	29688159		NR4A3	chr9	102589010
intron-intron	ENST00000331029	ENST00000330847	EWSR1	chr22	29688159	+	NR4A3	chr9	102589010	+
intron-intron	ENST00000331029	ENST00000338488	EWSR1	chr22	29688159		NR4A3	chr9	102589010
intron-intron	ENST00000331029	ENST00000338488	EWSR1	chr22	29688159	+	NR4A3	chr9	102589010	+
intron-intron	ENST00000331029	ENST00000395097	EWSR1	chr22	29688159		NR4A3	chr9	102589010
intron-intron	ENST00000331029	ENST00000395097	EWSR1	chr22	29688159	+	NR4A3	chr9	102589010	+
intron-intron	ENST00000333395	ENST00000330847	EWSR1	chr22	29688159		NR4A3	chr9	102589010
intron-intron	ENST00000333395	ENST00000330847	EWSR1	chr22	29688159	+	NR4A3	chr9	102589010	+
intron-intron	ENST00000333395	ENST00000330847	EWSR1	chr22	29688595	+	NR4A3	chr9	102591275	+
intron-intron	ENST00000333395	ENST00000338488	EWSR1	chr22	29688159		NR4A3	chr9	102589010
intron-intron	ENST00000333395	ENST00000338488	EWSR1	chr22	29688159	+	NR4A3	chr9	102589010	+
intron-intron	ENST00000333395	ENST00000338488	EWSR1	chr22	29688595	+	NR4A3	chr9	102591275	+
intron-intron	ENST00000333395	ENST00000395097	EWSR1	chr22	29688159		NR4A3	chr9	102589010
intron-intron	ENST00000333395	ENST00000395097	EWSR1	chr22	29688159	+	NR4A3	chr9	102589010	+
intron-intron	ENST00000333395	ENST00000395097	EWSR1	chr22	29688595	+	NR4A3	chr9	102591275	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

Top

Fusion Genomic Features for EWSR1-NR4A3

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
EWSR1	chr22	29688158	+	NR4A3	chr9	102589008	+	0.99972886	0.000271184
EWSR1	chr22	29683123	+	NR4A3	chr9	102587940	+	1.09E-07	0.9999999
EWSR1	chr22	29688158	+	NR4A3	chr9	102589008	+	0.99972886	0.000271184
EWSR1	chr22	29683123	+	NR4A3	chr9	102587940	+	1.09E-07	0.9999999

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for EWSR1-NR4A3

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:29688159/:102589010)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
EWSR1 Q01844	NR4A3 Q92570
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Transcriptional activator that binds to regulatory elements in promoter regions in a cell- and response element (target)-specific manner. Induces gene expression by binding as monomers to the NR4A1 response element (NBRE) 5'-AAAAGGTCA-3' site and as homodimers to the Nur response element (NurRE) site in the promoter of their regulated target genes (By similarity). Plays a role in the regulation of proliferation, survival and differentiation of many different cell types and also in metabolism and inflammation. Mediates proliferation of vascular smooth muscle, myeloid progenitor cell and type B pancreatic cells; promotes mitogen-induced vascular smooth muscle cell proliferation through transactivation of SKP2 promoter by binding a NBRE site (By similarity). Upon PDGF stimulation, stimulates vascular smooth muscle cell proliferation by regulating CCND1 and CCND2 expression. In islets, induces type B pancreatic cell proliferation through up-regulation of genes that activate cell cycle, as well as genes that cause degradation of the CDKN1A (By similarity). Negatively regulates myeloid progenitor cell proliferation by repressing RUNX1 in a NBRE site-independent manner. During inner ear, plays a role as a key mediator of the proliferative growth phase of semicircular canal development (By similarity). Mediates also survival of neuron and smooth muscle cells; mediates CREB-induced neuronal survival, and during hippocampus development, plays a critical role in pyramidal cell survival and axonal guidance. Is required for S phase entry of the cell cycle and survival of smooth muscle cells by inducing CCND1, resulting in RB1 phosphorylation. Binds to NBRE motif in CCND1 promoter, resulting in the activation of the promoter and CCND1 transcription (By similarity). Plays also a role in inflammation; upon TNF stimulation, mediates monocyte adhesion by inducing the expression of VCAM1 and ICAM1 by binding to the NBRE consensus site (By similarity) (PubMed:20558821). In mast cells activated by Fc-epsilon receptor cross-linking, promotes the synthesis and release of cytokines but impairs events leading to degranulation (By similarity). Plays also a role in metabolism; by modulating feeding behavior; and by playing a role in energy balance by inhibiting the glucocorticoid-induced orexigenic neuropeptides AGRP expression, at least in part by forming a complex with activated NR3C1 on the AGRP- glucocorticoid response element (GRE), and thus weakening the DNA binding activity of NR3C1. Upon catecholamines stimulation, regulates gene expression that controls oxidative metabolism in skeletal muscle (By similarity). Plays a role in glucose transport by regulating translocation of the SLC2A4 glucose transporter to the cell surface (PubMed:24022864). Finally, during gastrulation plays a crucial role in the formation of anterior mesoderm by controlling cell migration. Inhibits adipogenesis (By similarity). Also participates in cardiac hypertrophy by activating PARP1 (By similarity). {ECO:0000250\|UniProtKB:P51179, ECO:0000250\|UniProtKB:Q9QZB6, ECO:0000269\|PubMed:20558821, ECO:0000269\|PubMed:24022864}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Top

Fusion Gene Sequence for EWSR1-NR4A3

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for EWSR1-NR4A3

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for EWSR1-NR4A3

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for EWSR1-NR4A3

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source