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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:EXD3-CPSF7 (FusionGDB2 ID:27868)

Fusion Gene Summary for EXD3-CPSF7

Fusion gene summary

Fusion gene information	Fusion gene name: EXD3-CPSF7
	Fusion gene ID: 27868
		Hgene	Tgene
	Gene symbol	EXD3	CPSF7
	Gene ID	54932	79869
	Gene name	exonuclease 3'-5' domain containing 3	cleavage and polyadenylation specific factor 7
	Synonyms	Nbr\|mut-7	CFIm59
	Cytomap	9q34.3	11q12.2
	Type of gene	protein-coding	protein-coding
	Description	exonuclease mut-7 homologexonuclease 3'-5' domain-containing protein 3nibbler homologprobable exonuclease mut-7 homologtesticular tissue protein Li 125	cleavage and polyadenylation specificity factor subunit 7CPSF 59 kDa subunitcleavage and polyadenylation specificity factor 59 kDa subunitcleavage factor Im complex 59 kDa subunitpre-mRNA cleavage factor I, 59 kDa subunitpre-mRNA cleavage factor Im 5
	Modification date	20200313	20200313
	UniProtAcc	Q8N9H8	Q8N684
	Ensembl transtripts involved in fusion gene	ENST00000340951, ENST00000465160, ENST00000479452, ENST00000342129, ENST00000475006,	ENST00000394888, ENST00000439958, ENST00000448745, ENST00000541963, ENST00000494016, ENST00000340437,
Fusion gene scores	* DoF score	9 X 5 X 7=315	9 X 8 X 5=360
	# samples	10	10
	** MAII score	log2(10/315*10)=-1.65535182861255 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(10/360*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: EXD3 [Title/Abstract] AND CPSF7 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	EXD3(140289754)-CPSF7(61196762), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	CPSF7	GO:0051262	protein tetramerization	20695905
Tgene	CPSF7	GO:0051290	protein heterotetramerization	23187700
Tgene	CPSF7	GO:1990120	messenger ribonucleoprotein complex assembly	29276085

Fusion gene breakpoints across EXD3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CPSF7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	ESCA	TCGA-L5-A4OH	EXD3	chr9	140289754	-	CPSF7	chr11	61196762	-

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Fusion Gene ORF analysis for EXD3-CPSF7

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000340951	ENST00000394888	EXD3	chr9	140289754	-	CPSF7	chr11	61196762	-
5CDS-5UTR	ENST00000340951	ENST00000439958	EXD3	chr9	140289754	-	CPSF7	chr11	61196762	-
5CDS-5UTR	ENST00000340951	ENST00000448745	EXD3	chr9	140289754	-	CPSF7	chr11	61196762	-
5CDS-5UTR	ENST00000340951	ENST00000541963	EXD3	chr9	140289754	-	CPSF7	chr11	61196762	-
5CDS-5UTR	ENST00000465160	ENST00000394888	EXD3	chr9	140289754	-	CPSF7	chr11	61196762	-
5CDS-5UTR	ENST00000465160	ENST00000439958	EXD3	chr9	140289754	-	CPSF7	chr11	61196762	-
5CDS-5UTR	ENST00000465160	ENST00000448745	EXD3	chr9	140289754	-	CPSF7	chr11	61196762	-
5CDS-5UTR	ENST00000465160	ENST00000541963	EXD3	chr9	140289754	-	CPSF7	chr11	61196762	-
5CDS-5UTR	ENST00000479452	ENST00000394888	EXD3	chr9	140289754	-	CPSF7	chr11	61196762	-
5CDS-5UTR	ENST00000479452	ENST00000439958	EXD3	chr9	140289754	-	CPSF7	chr11	61196762	-
5CDS-5UTR	ENST00000479452	ENST00000448745	EXD3	chr9	140289754	-	CPSF7	chr11	61196762	-
5CDS-5UTR	ENST00000479452	ENST00000541963	EXD3	chr9	140289754	-	CPSF7	chr11	61196762	-
5CDS-intron	ENST00000340951	ENST00000494016	EXD3	chr9	140289754	-	CPSF7	chr11	61196762	-
5CDS-intron	ENST00000465160	ENST00000494016	EXD3	chr9	140289754	-	CPSF7	chr11	61196762	-
5CDS-intron	ENST00000479452	ENST00000494016	EXD3	chr9	140289754	-	CPSF7	chr11	61196762	-
5UTR-3CDS	ENST00000342129	ENST00000340437	EXD3	chr9	140289754	-	CPSF7	chr11	61196762	-
5UTR-3CDS	ENST00000475006	ENST00000340437	EXD3	chr9	140289754	-	CPSF7	chr11	61196762	-
5UTR-5UTR	ENST00000342129	ENST00000394888	EXD3	chr9	140289754	-	CPSF7	chr11	61196762	-
5UTR-5UTR	ENST00000342129	ENST00000439958	EXD3	chr9	140289754	-	CPSF7	chr11	61196762	-
5UTR-5UTR	ENST00000342129	ENST00000448745	EXD3	chr9	140289754	-	CPSF7	chr11	61196762	-
5UTR-5UTR	ENST00000342129	ENST00000541963	EXD3	chr9	140289754	-	CPSF7	chr11	61196762	-
5UTR-5UTR	ENST00000475006	ENST00000394888	EXD3	chr9	140289754	-	CPSF7	chr11	61196762	-
5UTR-5UTR	ENST00000475006	ENST00000439958	EXD3	chr9	140289754	-	CPSF7	chr11	61196762	-
5UTR-5UTR	ENST00000475006	ENST00000448745	EXD3	chr9	140289754	-	CPSF7	chr11	61196762	-
5UTR-5UTR	ENST00000475006	ENST00000541963	EXD3	chr9	140289754	-	CPSF7	chr11	61196762	-
5UTR-intron	ENST00000342129	ENST00000494016	EXD3	chr9	140289754	-	CPSF7	chr11	61196762	-
5UTR-intron	ENST00000475006	ENST00000494016	EXD3	chr9	140289754	-	CPSF7	chr11	61196762	-
In-frame	ENST00000340951	ENST00000340437	EXD3	chr9	140289754	-	CPSF7	chr11	61196762	-
In-frame	ENST00000465160	ENST00000340437	EXD3	chr9	140289754	-	CPSF7	chr11	61196762	-
In-frame	ENST00000479452	ENST00000340437	EXD3	chr9	140289754	-	CPSF7	chr11	61196762	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000340951	EXD3	chr9	140289754	-	ENST00000340437	CPSF7	chr11	61196762	-	3783	251	267	1721	484
ENST00000479452	EXD3	chr9	140289754	-	ENST00000340437	CPSF7	chr11	61196762	-	3676	144	160	1614	484
ENST00000465160	EXD3	chr9	140289754	-	ENST00000340437	CPSF7	chr11	61196762	-	3683	151	167	1621	484

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000340951	ENST00000340437	EXD3	chr9	140289754	-	CPSF7	chr11	61196762	-	0.002407378	0.9975926
ENST00000479452	ENST00000340437	EXD3	chr9	140289754	-	CPSF7	chr11	61196762	-	0.002346201	0.9976538
ENST00000465160	ENST00000340437	EXD3	chr9	140289754	-	CPSF7	chr11	61196762	-	0.002321591	0.99767846

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Fusion Genomic Features for EXD3-CPSF7

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for EXD3-CPSF7

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:140289754/chr11:61196762)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
EXD3 Q8N9H8	CPSF7 Q8N684
FUNCTION: Possesses 3'-5' exoribonuclease activity. Required for 3'-end trimming of AGO1-bound miRNAs (By similarity). {ECO:0000250}.	FUNCTION: Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs (PubMed:8626397, PubMed:17024186, PubMed:29276085). CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals) (PubMed:8626397, PubMed:17024186). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation (PubMed:23187700, PubMed:29276085). The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs (PubMed:20695905, PubMed:29276085). CPSF7 activates directly the mRNA 3'-processing machinery (PubMed:29276085). Binds to pA signals in RNA substrates (PubMed:8626397, PubMed:17024186). {ECO:0000269\|PubMed:17024186, ECO:0000269\|PubMed:20695905, ECO:0000269\|PubMed:23187700, ECO:0000269\|PubMed:29276085, ECO:0000269\|PubMed:8626397}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

CPSF7

chr9:140289754

chr11:61196762

ENST00000340437

218_329

1168.3333333333333

Compositional bias

Note=Pro-rich

Tgene

CPSF7

chr9:140289754

chr11:61196762

ENST00000340437

418_469

1168.3333333333333

Compositional bias

Note=Arg-rich

Tgene

CPSF7

chr9:140289754

chr11:61196762

ENST00000340437

51_54

1168.3333333333333

Compositional bias

Note=Poly-Pro

Tgene

CPSF7

chr9:140289754

chr11:61196762

ENST00000394888

218_329

1137.6666666666667

Compositional bias

Note=Pro-rich

Tgene

CPSF7

chr9:140289754

chr11:61196762

ENST00000394888

418_469

1137.6666666666667

Compositional bias

Note=Arg-rich

Tgene

CPSF7

chr9:140289754

chr11:61196762

ENST00000394888

51_54

1137.6666666666667

Compositional bias

Note=Poly-Pro

Tgene

CPSF7

chr9:140289754

chr11:61196762

ENST00000439958

218_329

1107.0

Compositional bias

Note=Pro-rich

Tgene

CPSF7

chr9:140289754

chr11:61196762

ENST00000439958

418_469

1107.0

Compositional bias

Note=Arg-rich

Tgene

CPSF7

chr9:140289754

chr11:61196762

ENST00000439958

51_54

1107.0

Compositional bias

Note=Poly-Pro

Tgene

CPSF7

chr9:140289754

chr11:61196762

ENST00000448745

218_329

500.3333333333333

Compositional bias

Note=Pro-rich

Tgene

CPSF7

chr9:140289754

chr11:61196762

ENST00000448745

418_469

500.3333333333333

Compositional bias

Note=Arg-rich

Tgene

CPSF7

chr9:140289754

chr11:61196762

ENST00000448745

51_54

500.3333333333333

Compositional bias

Note=Poly-Pro

Tgene

CPSF7

chr9:140289754

chr11:61196762

ENST00000340437

82_162

1168.3333333333333

Domain

RRM

Tgene

CPSF7

chr9:140289754

chr11:61196762

ENST00000394888

82_162

1137.6666666666667

Domain

RRM

Tgene

CPSF7

chr9:140289754

chr11:61196762

ENST00000439958

82_162

1107.0

Domain

RRM

Tgene

CPSF7

chr9:140289754

chr11:61196762

ENST00000448745

82_162

500.3333333333333

Domain

RRM

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

EXD3

chr9:140289754

chr11:61196762

ENST00000340951

517_571

877.0

Domain

Note=3'-5' exonuclease

Hgene

EXD3

chr9:140289754

chr11:61196762

ENST00000342129

517_571

515.0

Domain

Note=3'-5' exonuclease

Hgene

EXD3

chr9:140289754

chr11:61196762

ENST00000479452

517_571

247.0

Domain

Note=3'-5' exonuclease

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Fusion Gene Sequence for EXD3-CPSF7

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>27868_27868_1_EXD3-CPSF7_EXD3_chr9_140289754_ENST00000340951_CPSF7_chr11_61196762_ENST00000340437_length(transcript)=3783nt_BP=251nt
ACTTCCGCCGGGAGCTTTGTGCGCCCGGCTTCCTCGCCCCGCCCGCGCTGGCCTTGGTGCGCCGGATAAAGCCCTCCGGGCCAGCGGCTG
CGGTCGGGCCAAGGTTCCGCGCCGGGCGTGGACGGTGTGGGGCGGTCCCGGCCCCGCAGATCCTCGTTCCTAGCTGCCTGCCAGCGTCCT
CGGCCCGGCCCTGAGGATGGACCCAGGAGATCCCGCTGGTGACCCTGCCGCTGGCGAGCGCCACCGCATGGTGGCATCTTCCTTACTTTG
TCCATCCTCCGGACTCGCGATCTTCCTTCCGGAGCCATGTCAGAAGGAGTGGACTTGATTGATATATATGCTGACGAGGAGTTCAACCAG
GACCCAGAGTTCAACAATACAGATCAGATTGACCTGTATGATGATGTGCTGACAGCCACCTCACAGCCCTCAGATGACAGAAGCAGCAGC
ACTGAACCACCTCCTCCTGTTCGCCAGGAGCCATCTCCCAAGCCCAACAACAAGACCCCTGCAATTCTGTATACCTACAGTGGCCTGCGT
AATAGACGAGCTGCCGTTTATGTGGGCAGCTTCTCCTGGTGGACCACAGACCAGCAGCTGATCCAGGTTATTCGCTCTATAGGAGTCTAT
GATGTGGTGGAGTTGAAATTTGCAGAGAATCGAGCAAATGGCCAGTCCAAAGGGTATGCTGAGGTGGTGGTAGCCTCTGAAAACTCTGTC
CACAAATTGTTGGAACTCCTACCAGGGAAAGTTCTTAATGGAGAAAAAGTGGACGTGAGGCCGGCCACCCGGCAGAACCTGTCACAGTTT
GAGGCACAGGCTCGGAAACGTGAGTGTGTCCGAGTCCCAAGAGGGGGAATACCTCCACGGGCCCATTCCCGAGATTCTAGTGATTCTGCT
GATGGACGGGCCACACCCTCTGAGAACCTTGTACCCTCATCTGCTCGTGTGGATAAGCCCCCCAGTGTGCTGCCCTACTTCAATCGTCCT
CCTTCGGCCCTTCCCCTGATGGGTCTGCCCCCACCACCAATTCCACCCCCACCACCTCTCTCCTCAAGCTTTGGGGTCCCTCCTCCTCCT
CCTGGTATCCACTACCAGCATCTCATGCCCCCACCTCCTCGATTACCTCCTCATCTTGCTGTACCTCCCCCTGGGGCCATCCCACCTGCC
CTTCACCTCAATCCAGCCTTCTTCCCCCCACCAAACGCTACAGTGGGGCCTCCACCAGATACTTACATGAAGGCCTCTGCCCCCTATAAC
CACCATGGCAGCCGAGATTCGGGCCCTCCACCCTCTACAGTGAGTGAAGCCGAATTTGAAGATATCATGAAGCGAAACAGAGCAATTTCC
AGCAGTGCCATTTCCAAAGCAGTATCTGGAGCCAGTGCAGGGGATTACAGTGACGCAATTGAGACGCTGCTCACAGCCATTGCGGTTATC
AAACAGTCCCGGGTTGCCAATGATGAGCGTTGCCGTGTCCTCATCTCCTCTCTTAAGGACTGTCTTCATGGCATCGAAGCCAAGTCCTAC
AGTGTGGGTGCCAGTGGGAGCTCTTCCAGGAAAAGACATCGCTCCCGGGAAAGGTCACCTAGCCGGTCCCGGGAGAGCAGCAGGAGGCAC
CGGGATCTGCTTCATAATGAAGATCGGCATGATGATTATTTCCAAGAAAGGAACCGGGAGCATGAGAGACACCGGGATAGAGAACGGGAC
CGGCACCACTGAGAAAGGAGTCTGGTTGGAAGCAAATGTTTTTTTAATGGACTTGCATCTCCTCACCTTGATCAGGACTAAAGGACGGAG
GCCGCCCCACCCCCTTCCCTTTCCTCCAAACCCCTAACTCCCTCCAGACACCCAGGGAATACCCTCTGCCCCACAGGATTGAAGACTGCT
TGGCAGTCCTCCCAATCCCACACCTCCTGTTTGCCAGGGGAAAGAACCTAAAGACTTCGTGTGATTGGGAGGGGTGGCAGACAGGAAGAA
AACATGTCCAGGCCCCTGGTCTCCATAGAGAATGGTGCTTTGTCCAAGAAAACGTATGAGTTTCTGATTCTCCGGGAGCCGTTCAATGGT
GAGGTTGATGGGAAGACTTCCTTCCCAAAGAAAATAGATCCTCCATGCAGGATCTAGGAGAGTGACTGGGTGTGCCAAAATATGCCCAGG
GTCCTGCCCTCAGCACTAGATTTAATGGGGCCAAGAGGGTCCAAACCCCTTGCTAACATACCACTTCTTTGTTTAACTCCTTTACCTTTC
CAGCCCTTTGAGGAGGGACCATGAGAACAGAAATTACCTTATGAAAAGCTACTTCTGTTCCTGCTTTCCCTCTCACGTATTGACGGTTTA
TTTCTTTGACCTCCCAGAGGGCTGAACTCTTTCAACTCTGCGCTGCCCAGCCTTCTCAGTGGACTTGCCCCTCCTAAGCAGAGAAGGCCT
ATGAGGTTGCTTGCTGCTGGGAAGCCTGGCAGAGCCAATTACCACCCTCTGCTGCTTAGTGCTTGGGTACCTCTTGCAATAACCAGCTCT
TAGTTGTTCCCTTTCCCTGGGGCTTTTCCATTTAACACATGGAGCCCTTCCCCCAGAAGGCTACTTCCTTGTTTTAGAGGAAGGTACTGC
CCATTGGGAGATGGGGACATTGGGACCTCAGCAATGAAGAACCCTTGTGAAGTAACCAGGAGGAATGGGGAAAGAAGCAAGTTGGGCAGG
ATATGGCCTACTTCCATAGGCTTTTCTTTTTTCAGGTTTGATGTAAGCATGGGCTTACATCCCCCAGGTACATACTTTTACTTATTGTGG
GATAACCTGGCACTAGTAGGCAGGTAAAGTCACAAATTTGGTGTCTTTTCACCTTTTGACTGTTGACTTAATAGCTCCTCTCACTCTGCC
TGGAGATACTTCCTGCCTCAGATGAGGAGCCAGAAGAAACAGAGCCCGACTTGAATGAACTCAGCTCAGAGTTCTAAGGACCAGCATTCT
GGGGGCCATTTTCTCTACAGGCAAATGGAATTGCTTTTCCATAACATCCAAATTGTAATGTGGTTGCTGCTGAAGGAGGAGGCAGCAGCG
AGGTCCTGCGGTACCCATGGGGTGATGCTACTTCTGCATGCATCTACAGGGCATCTGACACCTAACATGAGACGTGGCATGTGAGATGAG
ACTTGGCATGTGAGACATAGGGTCACTAGAGACCCTTCTGGGTCAGAGGAGAGAGACTGAATTGGACTAAACCCGTCCTCTGTTCCCAGC
ACGTTTCTCATATAGCCCTCAGTCACTGAGGGAGTCCCCCGCAGGATTGGAGAGGCACATTCCCTTGGGACAGAGGCTACAGGTTGGAGC
TTTTTTTCCCCTGTCCCCCAACCCCATCCCCACCTCCACTTCAGAACATGGCACCCCACCCAACTGGCCAAGTGTTAAGTGATGTGCTTA
TTGAGAGCAACTCCGGGTGTCTTTTAAAATGTAGAGAAAAGGTGACAGTTTAAGGAAAAATATATATAGAATACCAGAAATGCCGTTTAC
CCGGAGAATTTTTTTCTCCCCATTTGTTTTGTTTTTACTCAATGACACCATTTTTAGTTTTATTTCCTGATAGCAAAAGGAAAAAAAACA
CCCATCCCTCAAAAAGGCCAAGGTCCCGTCCCCCTGTTGTCGGTGATTTGTTTGTCTTTCTGATAGGTTGAAAATTGTGTAATAAACTTG
ATGACGCTGTCAATCTTTTATACTGCATTGTATTTTTTTCCTTTTGTAACAAAATATTTTTAAATAATAAATGGGGTGTGAGCTGTTTTA

>27868_27868_1_EXD3-CPSF7_EXD3_chr9_140289754_ENST00000340951_CPSF7_chr11_61196762_ENST00000340437_length(amino acids)=484AA_BP=
MSILRTRDLPSGAMSEGVDLIDIYADEEFNQDPEFNNTDQIDLYDDVLTATSQPSDDRSSSTEPPPPVRQEPSPKPNNKTPAILYTYSGL
RNRRAAVYVGSFSWWTTDQQLIQVIRSIGVYDVVELKFAENRANGQSKGYAEVVVASENSVHKLLELLPGKVLNGEKVDVRPATRQNLSQ
FEAQARKRECVRVPRGGIPPRAHSRDSSDSADGRATPSENLVPSSARVDKPPSVLPYFNRPPSALPLMGLPPPPIPPPPPLSSSFGVPPP
PPGIHYQHLMPPPPRLPPHLAVPPPGAIPPALHLNPAFFPPPNATVGPPPDTYMKASAPYNHHGSRDSGPPPSTVSEAEFEDIMKRNRAI
SSSAISKAVSGASAGDYSDAIETLLTAIAVIKQSRVANDERCRVLISSLKDCLHGIEAKSYSVGASGSSSRKRHRSRERSPSRSRESSRR

--------------------------------------------------------------
>27868_27868_2_EXD3-CPSF7_EXD3_chr9_140289754_ENST00000465160_CPSF7_chr11_61196762_ENST00000340437_length(transcript)=3683nt_BP=151nt
AAGGTTCCGCGCCGGGCGTGGACGGTGTGGGGCGGTCCCGGCCCCGCAGATCCTCGTTCCTAGCTGCCTGCCAGCGTCCTCGGCCCGGCC
CTGAGGATGGACCCAGGAGATCCCGCTGGTGACCCTGCCGCTGGCGAGCGCCACCGCATGGTGGCATCTTCCTTACTTTGTCCATCCTCC
GGACTCGCGATCTTCCTTCCGGAGCCATGTCAGAAGGAGTGGACTTGATTGATATATATGCTGACGAGGAGTTCAACCAGGACCCAGAGT
TCAACAATACAGATCAGATTGACCTGTATGATGATGTGCTGACAGCCACCTCACAGCCCTCAGATGACAGAAGCAGCAGCACTGAACCAC
CTCCTCCTGTTCGCCAGGAGCCATCTCCCAAGCCCAACAACAAGACCCCTGCAATTCTGTATACCTACAGTGGCCTGCGTAATAGACGAG
CTGCCGTTTATGTGGGCAGCTTCTCCTGGTGGACCACAGACCAGCAGCTGATCCAGGTTATTCGCTCTATAGGAGTCTATGATGTGGTGG
AGTTGAAATTTGCAGAGAATCGAGCAAATGGCCAGTCCAAAGGGTATGCTGAGGTGGTGGTAGCCTCTGAAAACTCTGTCCACAAATTGT
TGGAACTCCTACCAGGGAAAGTTCTTAATGGAGAAAAAGTGGACGTGAGGCCGGCCACCCGGCAGAACCTGTCACAGTTTGAGGCACAGG
CTCGGAAACGTGAGTGTGTCCGAGTCCCAAGAGGGGGAATACCTCCACGGGCCCATTCCCGAGATTCTAGTGATTCTGCTGATGGACGGG
CCACACCCTCTGAGAACCTTGTACCCTCATCTGCTCGTGTGGATAAGCCCCCCAGTGTGCTGCCCTACTTCAATCGTCCTCCTTCGGCCC
TTCCCCTGATGGGTCTGCCCCCACCACCAATTCCACCCCCACCACCTCTCTCCTCAAGCTTTGGGGTCCCTCCTCCTCCTCCTGGTATCC
ACTACCAGCATCTCATGCCCCCACCTCCTCGATTACCTCCTCATCTTGCTGTACCTCCCCCTGGGGCCATCCCACCTGCCCTTCACCTCA
ATCCAGCCTTCTTCCCCCCACCAAACGCTACAGTGGGGCCTCCACCAGATACTTACATGAAGGCCTCTGCCCCCTATAACCACCATGGCA
GCCGAGATTCGGGCCCTCCACCCTCTACAGTGAGTGAAGCCGAATTTGAAGATATCATGAAGCGAAACAGAGCAATTTCCAGCAGTGCCA
TTTCCAAAGCAGTATCTGGAGCCAGTGCAGGGGATTACAGTGACGCAATTGAGACGCTGCTCACAGCCATTGCGGTTATCAAACAGTCCC
GGGTTGCCAATGATGAGCGTTGCCGTGTCCTCATCTCCTCTCTTAAGGACTGTCTTCATGGCATCGAAGCCAAGTCCTACAGTGTGGGTG
CCAGTGGGAGCTCTTCCAGGAAAAGACATCGCTCCCGGGAAAGGTCACCTAGCCGGTCCCGGGAGAGCAGCAGGAGGCACCGGGATCTGC
TTCATAATGAAGATCGGCATGATGATTATTTCCAAGAAAGGAACCGGGAGCATGAGAGACACCGGGATAGAGAACGGGACCGGCACCACT
GAGAAAGGAGTCTGGTTGGAAGCAAATGTTTTTTTAATGGACTTGCATCTCCTCACCTTGATCAGGACTAAAGGACGGAGGCCGCCCCAC
CCCCTTCCCTTTCCTCCAAACCCCTAACTCCCTCCAGACACCCAGGGAATACCCTCTGCCCCACAGGATTGAAGACTGCTTGGCAGTCCT
CCCAATCCCACACCTCCTGTTTGCCAGGGGAAAGAACCTAAAGACTTCGTGTGATTGGGAGGGGTGGCAGACAGGAAGAAAACATGTCCA
GGCCCCTGGTCTCCATAGAGAATGGTGCTTTGTCCAAGAAAACGTATGAGTTTCTGATTCTCCGGGAGCCGTTCAATGGTGAGGTTGATG
GGAAGACTTCCTTCCCAAAGAAAATAGATCCTCCATGCAGGATCTAGGAGAGTGACTGGGTGTGCCAAAATATGCCCAGGGTCCTGCCCT
CAGCACTAGATTTAATGGGGCCAAGAGGGTCCAAACCCCTTGCTAACATACCACTTCTTTGTTTAACTCCTTTACCTTTCCAGCCCTTTG
AGGAGGGACCATGAGAACAGAAATTACCTTATGAAAAGCTACTTCTGTTCCTGCTTTCCCTCTCACGTATTGACGGTTTATTTCTTTGAC
CTCCCAGAGGGCTGAACTCTTTCAACTCTGCGCTGCCCAGCCTTCTCAGTGGACTTGCCCCTCCTAAGCAGAGAAGGCCTATGAGGTTGC
TTGCTGCTGGGAAGCCTGGCAGAGCCAATTACCACCCTCTGCTGCTTAGTGCTTGGGTACCTCTTGCAATAACCAGCTCTTAGTTGTTCC
CTTTCCCTGGGGCTTTTCCATTTAACACATGGAGCCCTTCCCCCAGAAGGCTACTTCCTTGTTTTAGAGGAAGGTACTGCCCATTGGGAG
ATGGGGACATTGGGACCTCAGCAATGAAGAACCCTTGTGAAGTAACCAGGAGGAATGGGGAAAGAAGCAAGTTGGGCAGGATATGGCCTA
CTTCCATAGGCTTTTCTTTTTTCAGGTTTGATGTAAGCATGGGCTTACATCCCCCAGGTACATACTTTTACTTATTGTGGGATAACCTGG
CACTAGTAGGCAGGTAAAGTCACAAATTTGGTGTCTTTTCACCTTTTGACTGTTGACTTAATAGCTCCTCTCACTCTGCCTGGAGATACT
TCCTGCCTCAGATGAGGAGCCAGAAGAAACAGAGCCCGACTTGAATGAACTCAGCTCAGAGTTCTAAGGACCAGCATTCTGGGGGCCATT
TTCTCTACAGGCAAATGGAATTGCTTTTCCATAACATCCAAATTGTAATGTGGTTGCTGCTGAAGGAGGAGGCAGCAGCGAGGTCCTGCG
GTACCCATGGGGTGATGCTACTTCTGCATGCATCTACAGGGCATCTGACACCTAACATGAGACGTGGCATGTGAGATGAGACTTGGCATG
TGAGACATAGGGTCACTAGAGACCCTTCTGGGTCAGAGGAGAGAGACTGAATTGGACTAAACCCGTCCTCTGTTCCCAGCACGTTTCTCA
TATAGCCCTCAGTCACTGAGGGAGTCCCCCGCAGGATTGGAGAGGCACATTCCCTTGGGACAGAGGCTACAGGTTGGAGCTTTTTTTCCC
CTGTCCCCCAACCCCATCCCCACCTCCACTTCAGAACATGGCACCCCACCCAACTGGCCAAGTGTTAAGTGATGTGCTTATTGAGAGCAA
CTCCGGGTGTCTTTTAAAATGTAGAGAAAAGGTGACAGTTTAAGGAAAAATATATATAGAATACCAGAAATGCCGTTTACCCGGAGAATT
TTTTTCTCCCCATTTGTTTTGTTTTTACTCAATGACACCATTTTTAGTTTTATTTCCTGATAGCAAAAGGAAAAAAAACACCCATCCCTC
AAAAAGGCCAAGGTCCCGTCCCCCTGTTGTCGGTGATTTGTTTGTCTTTCTGATAGGTTGAAAATTGTGTAATAAACTTGATGACGCTGT

>27868_27868_2_EXD3-CPSF7_EXD3_chr9_140289754_ENST00000465160_CPSF7_chr11_61196762_ENST00000340437_length(amino acids)=484AA_BP=
MSILRTRDLPSGAMSEGVDLIDIYADEEFNQDPEFNNTDQIDLYDDVLTATSQPSDDRSSSTEPPPPVRQEPSPKPNNKTPAILYTYSGL
RNRRAAVYVGSFSWWTTDQQLIQVIRSIGVYDVVELKFAENRANGQSKGYAEVVVASENSVHKLLELLPGKVLNGEKVDVRPATRQNLSQ
FEAQARKRECVRVPRGGIPPRAHSRDSSDSADGRATPSENLVPSSARVDKPPSVLPYFNRPPSALPLMGLPPPPIPPPPPLSSSFGVPPP
PPGIHYQHLMPPPPRLPPHLAVPPPGAIPPALHLNPAFFPPPNATVGPPPDTYMKASAPYNHHGSRDSGPPPSTVSEAEFEDIMKRNRAI
SSSAISKAVSGASAGDYSDAIETLLTAIAVIKQSRVANDERCRVLISSLKDCLHGIEAKSYSVGASGSSSRKRHRSRERSPSRSRESSRR

--------------------------------------------------------------
>27868_27868_3_EXD3-CPSF7_EXD3_chr9_140289754_ENST00000479452_CPSF7_chr11_61196762_ENST00000340437_length(transcript)=3676nt_BP=144nt
CGCGCCGGGCGTGGACGGTGTGGGGCGGTCCCGGCCCCGCAGATCCTCGTTCCTAGCTGCCTGCCAGCGTCCTCGGCCCGGCCCTGAGGA
TGGACCCAGGAGATCCCGCTGGTGACCCTGCCGCTGGCGAGCGCCACCGCATGGTGGCATCTTCCTTACTTTGTCCATCCTCCGGACTCG
CGATCTTCCTTCCGGAGCCATGTCAGAAGGAGTGGACTTGATTGATATATATGCTGACGAGGAGTTCAACCAGGACCCAGAGTTCAACAA
TACAGATCAGATTGACCTGTATGATGATGTGCTGACAGCCACCTCACAGCCCTCAGATGACAGAAGCAGCAGCACTGAACCACCTCCTCC
TGTTCGCCAGGAGCCATCTCCCAAGCCCAACAACAAGACCCCTGCAATTCTGTATACCTACAGTGGCCTGCGTAATAGACGAGCTGCCGT
TTATGTGGGCAGCTTCTCCTGGTGGACCACAGACCAGCAGCTGATCCAGGTTATTCGCTCTATAGGAGTCTATGATGTGGTGGAGTTGAA
ATTTGCAGAGAATCGAGCAAATGGCCAGTCCAAAGGGTATGCTGAGGTGGTGGTAGCCTCTGAAAACTCTGTCCACAAATTGTTGGAACT
CCTACCAGGGAAAGTTCTTAATGGAGAAAAAGTGGACGTGAGGCCGGCCACCCGGCAGAACCTGTCACAGTTTGAGGCACAGGCTCGGAA
ACGTGAGTGTGTCCGAGTCCCAAGAGGGGGAATACCTCCACGGGCCCATTCCCGAGATTCTAGTGATTCTGCTGATGGACGGGCCACACC
CTCTGAGAACCTTGTACCCTCATCTGCTCGTGTGGATAAGCCCCCCAGTGTGCTGCCCTACTTCAATCGTCCTCCTTCGGCCCTTCCCCT
GATGGGTCTGCCCCCACCACCAATTCCACCCCCACCACCTCTCTCCTCAAGCTTTGGGGTCCCTCCTCCTCCTCCTGGTATCCACTACCA
GCATCTCATGCCCCCACCTCCTCGATTACCTCCTCATCTTGCTGTACCTCCCCCTGGGGCCATCCCACCTGCCCTTCACCTCAATCCAGC
CTTCTTCCCCCCACCAAACGCTACAGTGGGGCCTCCACCAGATACTTACATGAAGGCCTCTGCCCCCTATAACCACCATGGCAGCCGAGA
TTCGGGCCCTCCACCCTCTACAGTGAGTGAAGCCGAATTTGAAGATATCATGAAGCGAAACAGAGCAATTTCCAGCAGTGCCATTTCCAA
AGCAGTATCTGGAGCCAGTGCAGGGGATTACAGTGACGCAATTGAGACGCTGCTCACAGCCATTGCGGTTATCAAACAGTCCCGGGTTGC
CAATGATGAGCGTTGCCGTGTCCTCATCTCCTCTCTTAAGGACTGTCTTCATGGCATCGAAGCCAAGTCCTACAGTGTGGGTGCCAGTGG
GAGCTCTTCCAGGAAAAGACATCGCTCCCGGGAAAGGTCACCTAGCCGGTCCCGGGAGAGCAGCAGGAGGCACCGGGATCTGCTTCATAA
TGAAGATCGGCATGATGATTATTTCCAAGAAAGGAACCGGGAGCATGAGAGACACCGGGATAGAGAACGGGACCGGCACCACTGAGAAAG
GAGTCTGGTTGGAAGCAAATGTTTTTTTAATGGACTTGCATCTCCTCACCTTGATCAGGACTAAAGGACGGAGGCCGCCCCACCCCCTTC
CCTTTCCTCCAAACCCCTAACTCCCTCCAGACACCCAGGGAATACCCTCTGCCCCACAGGATTGAAGACTGCTTGGCAGTCCTCCCAATC
CCACACCTCCTGTTTGCCAGGGGAAAGAACCTAAAGACTTCGTGTGATTGGGAGGGGTGGCAGACAGGAAGAAAACATGTCCAGGCCCCT
GGTCTCCATAGAGAATGGTGCTTTGTCCAAGAAAACGTATGAGTTTCTGATTCTCCGGGAGCCGTTCAATGGTGAGGTTGATGGGAAGAC
TTCCTTCCCAAAGAAAATAGATCCTCCATGCAGGATCTAGGAGAGTGACTGGGTGTGCCAAAATATGCCCAGGGTCCTGCCCTCAGCACT
AGATTTAATGGGGCCAAGAGGGTCCAAACCCCTTGCTAACATACCACTTCTTTGTTTAACTCCTTTACCTTTCCAGCCCTTTGAGGAGGG
ACCATGAGAACAGAAATTACCTTATGAAAAGCTACTTCTGTTCCTGCTTTCCCTCTCACGTATTGACGGTTTATTTCTTTGACCTCCCAG
AGGGCTGAACTCTTTCAACTCTGCGCTGCCCAGCCTTCTCAGTGGACTTGCCCCTCCTAAGCAGAGAAGGCCTATGAGGTTGCTTGCTGC
TGGGAAGCCTGGCAGAGCCAATTACCACCCTCTGCTGCTTAGTGCTTGGGTACCTCTTGCAATAACCAGCTCTTAGTTGTTCCCTTTCCC
TGGGGCTTTTCCATTTAACACATGGAGCCCTTCCCCCAGAAGGCTACTTCCTTGTTTTAGAGGAAGGTACTGCCCATTGGGAGATGGGGA
CATTGGGACCTCAGCAATGAAGAACCCTTGTGAAGTAACCAGGAGGAATGGGGAAAGAAGCAAGTTGGGCAGGATATGGCCTACTTCCAT
AGGCTTTTCTTTTTTCAGGTTTGATGTAAGCATGGGCTTACATCCCCCAGGTACATACTTTTACTTATTGTGGGATAACCTGGCACTAGT
AGGCAGGTAAAGTCACAAATTTGGTGTCTTTTCACCTTTTGACTGTTGACTTAATAGCTCCTCTCACTCTGCCTGGAGATACTTCCTGCC
TCAGATGAGGAGCCAGAAGAAACAGAGCCCGACTTGAATGAACTCAGCTCAGAGTTCTAAGGACCAGCATTCTGGGGGCCATTTTCTCTA
CAGGCAAATGGAATTGCTTTTCCATAACATCCAAATTGTAATGTGGTTGCTGCTGAAGGAGGAGGCAGCAGCGAGGTCCTGCGGTACCCA
TGGGGTGATGCTACTTCTGCATGCATCTACAGGGCATCTGACACCTAACATGAGACGTGGCATGTGAGATGAGACTTGGCATGTGAGACA
TAGGGTCACTAGAGACCCTTCTGGGTCAGAGGAGAGAGACTGAATTGGACTAAACCCGTCCTCTGTTCCCAGCACGTTTCTCATATAGCC
CTCAGTCACTGAGGGAGTCCCCCGCAGGATTGGAGAGGCACATTCCCTTGGGACAGAGGCTACAGGTTGGAGCTTTTTTTCCCCTGTCCC
CCAACCCCATCCCCACCTCCACTTCAGAACATGGCACCCCACCCAACTGGCCAAGTGTTAAGTGATGTGCTTATTGAGAGCAACTCCGGG
TGTCTTTTAAAATGTAGAGAAAAGGTGACAGTTTAAGGAAAAATATATATAGAATACCAGAAATGCCGTTTACCCGGAGAATTTTTTTCT
CCCCATTTGTTTTGTTTTTACTCAATGACACCATTTTTAGTTTTATTTCCTGATAGCAAAAGGAAAAAAAACACCCATCCCTCAAAAAGG
CCAAGGTCCCGTCCCCCTGTTGTCGGTGATTTGTTTGTCTTTCTGATAGGTTGAAAATTGTGTAATAAACTTGATGACGCTGTCAATCTT

>27868_27868_3_EXD3-CPSF7_EXD3_chr9_140289754_ENST00000479452_CPSF7_chr11_61196762_ENST00000340437_length(amino acids)=484AA_BP=
MSILRTRDLPSGAMSEGVDLIDIYADEEFNQDPEFNNTDQIDLYDDVLTATSQPSDDRSSSTEPPPPVRQEPSPKPNNKTPAILYTYSGL
RNRRAAVYVGSFSWWTTDQQLIQVIRSIGVYDVVELKFAENRANGQSKGYAEVVVASENSVHKLLELLPGKVLNGEKVDVRPATRQNLSQ
FEAQARKRECVRVPRGGIPPRAHSRDSSDSADGRATPSENLVPSSARVDKPPSVLPYFNRPPSALPLMGLPPPPIPPPPPLSSSFGVPPP
PPGIHYQHLMPPPPRLPPHLAVPPPGAIPPALHLNPAFFPPPNATVGPPPDTYMKASAPYNHHGSRDSGPPPSTVSEAEFEDIMKRNRAI
SSSAISKAVSGASAGDYSDAIETLLTAIAVIKQSRVANDERCRVLISSLKDCLHGIEAKSYSVGASGSSSRKRHRSRERSPSRSRESSRR

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for EXD3-CPSF7

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for EXD3-CPSF7

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for EXD3-CPSF7

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source