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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:EXOC4-LRGUK (FusionGDB2 ID:27905) |
Fusion Gene Summary for EXOC4-LRGUK |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: EXOC4-LRGUK | Fusion gene ID: 27905 | Hgene | Tgene | Gene symbol | EXOC4 | LRGUK | Gene ID | 60412 | 136332 |
| Gene name | exocyst complex component 4 | leucine rich repeats and guanylate kinase domain containing | |
| Synonyms | SEC8|SEC8L1|Sec8p | CFAP246 | |
| Cytomap | 7q33 | 7q33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | exocyst complex component 4SEC8-like 1exocyst complex component Sec8 | leucine-rich repeat and guanylate kinase domain-containing protein | |
| Modification date | 20200320 | 20200322 | |
| UniProtAcc | Q96A65 | Q96M69 | |
| Ensembl transtripts involved in fusion gene | ENST00000460346, ENST00000253861, ENST00000539845, ENST00000545148, ENST00000393161, ENST00000541309, | ENST00000285928, ENST00000473068, | |
| Fusion gene scores | * DoF score | 29 X 25 X 11=7975 | 3 X 6 X 3=54 |
| # samples | 30 | 5 | |
| ** MAII score | log2(30/7975*10)=-4.73245011304371 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/54*10)=-0.111031312388744 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: EXOC4 [Title/Abstract] AND LRGUK [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | EXOC4(133314894)-LRGUK(133868486), # samples:1 EXOC4(133502297)-LRGUK(133932308), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene breakpoints across EXOC4 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across LRGUK (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | BRCA | TCGA-E2-A1LL-01A | EXOC4 | chr7 | 133314894 | + | LRGUK | chr7 | 133868486 | + |
| ChimerDB4 | OV | TCGA-25-1321-01A | EXOC4 | chr7 | 133502297 | + | LRGUK | chr7 | 133932308 | + |
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Fusion Gene ORF analysis for EXOC4-LRGUK |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3CDS | ENST00000460346 | ENST00000285928 | EXOC4 | chr7 | 133314894 | + | LRGUK | chr7 | 133868486 | + |
| 3UTR-3CDS | ENST00000460346 | ENST00000285928 | EXOC4 | chr7 | 133502297 | + | LRGUK | chr7 | 133932308 | + |
| 3UTR-intron | ENST00000460346 | ENST00000473068 | EXOC4 | chr7 | 133314894 | + | LRGUK | chr7 | 133868486 | + |
| 3UTR-intron | ENST00000460346 | ENST00000473068 | EXOC4 | chr7 | 133502297 | + | LRGUK | chr7 | 133932308 | + |
| 5CDS-intron | ENST00000253861 | ENST00000473068 | EXOC4 | chr7 | 133314894 | + | LRGUK | chr7 | 133868486 | + |
| 5CDS-intron | ENST00000253861 | ENST00000473068 | EXOC4 | chr7 | 133502297 | + | LRGUK | chr7 | 133932308 | + |
| 5CDS-intron | ENST00000539845 | ENST00000473068 | EXOC4 | chr7 | 133314894 | + | LRGUK | chr7 | 133868486 | + |
| 5CDS-intron | ENST00000539845 | ENST00000473068 | EXOC4 | chr7 | 133502297 | + | LRGUK | chr7 | 133932308 | + |
| 5CDS-intron | ENST00000545148 | ENST00000473068 | EXOC4 | chr7 | 133314894 | + | LRGUK | chr7 | 133868486 | + |
| 5CDS-intron | ENST00000545148 | ENST00000473068 | EXOC4 | chr7 | 133502297 | + | LRGUK | chr7 | 133932308 | + |
| In-frame | ENST00000253861 | ENST00000285928 | EXOC4 | chr7 | 133314894 | + | LRGUK | chr7 | 133868486 | + |
| In-frame | ENST00000253861 | ENST00000285928 | EXOC4 | chr7 | 133502297 | + | LRGUK | chr7 | 133932308 | + |
| In-frame | ENST00000539845 | ENST00000285928 | EXOC4 | chr7 | 133314894 | + | LRGUK | chr7 | 133868486 | + |
| In-frame | ENST00000539845 | ENST00000285928 | EXOC4 | chr7 | 133502297 | + | LRGUK | chr7 | 133932308 | + |
| In-frame | ENST00000545148 | ENST00000285928 | EXOC4 | chr7 | 133314894 | + | LRGUK | chr7 | 133868486 | + |
| In-frame | ENST00000545148 | ENST00000285928 | EXOC4 | chr7 | 133502297 | + | LRGUK | chr7 | 133932308 | + |
| intron-3CDS | ENST00000393161 | ENST00000285928 | EXOC4 | chr7 | 133314894 | + | LRGUK | chr7 | 133868486 | + |
| intron-3CDS | ENST00000393161 | ENST00000285928 | EXOC4 | chr7 | 133502297 | + | LRGUK | chr7 | 133932308 | + |
| intron-3CDS | ENST00000541309 | ENST00000285928 | EXOC4 | chr7 | 133314894 | + | LRGUK | chr7 | 133868486 | + |
| intron-3CDS | ENST00000541309 | ENST00000285928 | EXOC4 | chr7 | 133502297 | + | LRGUK | chr7 | 133932308 | + |
| intron-intron | ENST00000393161 | ENST00000473068 | EXOC4 | chr7 | 133314894 | + | LRGUK | chr7 | 133868486 | + |
| intron-intron | ENST00000393161 | ENST00000473068 | EXOC4 | chr7 | 133502297 | + | LRGUK | chr7 | 133932308 | + |
| intron-intron | ENST00000541309 | ENST00000473068 | EXOC4 | chr7 | 133314894 | + | LRGUK | chr7 | 133868486 | + |
| intron-intron | ENST00000541309 | ENST00000473068 | EXOC4 | chr7 | 133502297 | + | LRGUK | chr7 | 133932308 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000253861 | EXOC4 | chr7 | 133314894 | + | ENST00000285928 | LRGUK | chr7 | 133868486 | + | 3423 | 1543 | 29 | 2806 | 925 |
| ENST00000539845 | EXOC4 | chr7 | 133314894 | + | ENST00000285928 | LRGUK | chr7 | 133868486 | + | 3430 | 1550 | 126 | 2813 | 895 |
| ENST00000545148 | EXOC4 | chr7 | 133314894 | + | ENST00000285928 | LRGUK | chr7 | 133868486 | + | 2277 | 397 | 14 | 1660 | 548 |
| ENST00000253861 | EXOC4 | chr7 | 133502297 | + | ENST00000285928 | LRGUK | chr7 | 133932308 | + | 2874 | 1763 | 29 | 2257 | 742 |
| ENST00000539845 | EXOC4 | chr7 | 133502297 | + | ENST00000285928 | LRGUK | chr7 | 133932308 | + | 2881 | 1770 | 126 | 2264 | 712 |
| ENST00000545148 | EXOC4 | chr7 | 133502297 | + | ENST00000285928 | LRGUK | chr7 | 133932308 | + | 1728 | 617 | 14 | 1111 | 365 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000253861 | ENST00000285928 | EXOC4 | chr7 | 133314894 | + | LRGUK | chr7 | 133868486 | + | 0.000879453 | 0.99912053 |
| ENST00000539845 | ENST00000285928 | EXOC4 | chr7 | 133314894 | + | LRGUK | chr7 | 133868486 | + | 0.002999542 | 0.9970004 |
| ENST00000545148 | ENST00000285928 | EXOC4 | chr7 | 133314894 | + | LRGUK | chr7 | 133868486 | + | 0.00063149 | 0.9993685 |
| ENST00000253861 | ENST00000285928 | EXOC4 | chr7 | 133502297 | + | LRGUK | chr7 | 133932308 | + | 0.001693051 | 0.998307 |
| ENST00000539845 | ENST00000285928 | EXOC4 | chr7 | 133502297 | + | LRGUK | chr7 | 133932308 | + | 0.004731023 | 0.995269 |
| ENST00000545148 | ENST00000285928 | EXOC4 | chr7 | 133502297 | + | LRGUK | chr7 | 133932308 | + | 0.004378583 | 0.9956214 |
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Fusion Genomic Features for EXOC4-LRGUK |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| EXOC4 | chr7 | 133502297 | + | LRGUK | chr7 | 133932307 | + | 3.07E-05 | 0.99996936 |
| EXOC4 | chr7 | 133314894 | + | LRGUK | chr7 | 133868485 | + | 6.23E-07 | 0.9999994 |
| EXOC4 | chr7 | 133502297 | + | LRGUK | chr7 | 133932307 | + | 3.07E-05 | 0.99996936 |
| EXOC4 | chr7 | 133314894 | + | LRGUK | chr7 | 133868485 | + | 6.23E-07 | 0.9999994 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for EXOC4-LRGUK |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:133314894/chr7:133868486) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| EXOC4 | LRGUK |
| FUNCTION: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. {ECO:0000250}. | FUNCTION: Involved in multiple aspects of sperm assembly including acrosome attachment, shaping of the sperm head and in the early aspects of axoneme development. Not essential for primary cilium biogenesis. {ECO:0000250|UniProtKB:Q9D5S7}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | EXOC4 | chr7:133314894 | chr7:133868486 | ENST00000253861 | + | 10 | 18 | 32_114 | 504 | 975.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | EXOC4 | chr7:133502297 | chr7:133932308 | ENST00000253861 | + | 11 | 18 | 32_114 | 578 | 975.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | LRGUK | chr7:133314894 | chr7:133868486 | ENST00000285928 | 9 | 20 | 414_597 | 404 | 826.0 | Domain | Guanylate kinase-like | |
| Tgene | LRGUK | chr7:133314894 | chr7:133868486 | ENST00000285928 | 9 | 20 | 421_428 | 404 | 826.0 | Nucleotide binding | ATP |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | EXOC4 | chr7:133314894 | chr7:133868486 | ENST00000393161 | + | 1 | 10 | 32_114 | 0 | 474.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | EXOC4 | chr7:133502297 | chr7:133932308 | ENST00000393161 | + | 1 | 10 | 32_114 | 0 | 474.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | LRGUK | chr7:133314894 | chr7:133868486 | ENST00000285928 | 9 | 20 | 337_375 | 404 | 826.0 | Domain | Note=LRRCT | |
| Tgene | LRGUK | chr7:133502297 | chr7:133932308 | ENST00000285928 | 15 | 20 | 337_375 | 661 | 826.0 | Domain | Note=LRRCT | |
| Tgene | LRGUK | chr7:133502297 | chr7:133932308 | ENST00000285928 | 15 | 20 | 414_597 | 661 | 826.0 | Domain | Guanylate kinase-like | |
| Tgene | LRGUK | chr7:133502297 | chr7:133932308 | ENST00000285928 | 15 | 20 | 421_428 | 661 | 826.0 | Nucleotide binding | ATP | |
| Tgene | LRGUK | chr7:133314894 | chr7:133868486 | ENST00000285928 | 9 | 20 | 129_149 | 404 | 826.0 | Repeat | Note=LRR 1 | |
| Tgene | LRGUK | chr7:133314894 | chr7:133868486 | ENST00000285928 | 9 | 20 | 150_171 | 404 | 826.0 | Repeat | Note=LRR 2 | |
| Tgene | LRGUK | chr7:133314894 | chr7:133868486 | ENST00000285928 | 9 | 20 | 172_193 | 404 | 826.0 | Repeat | Note=LRR 3 | |
| Tgene | LRGUK | chr7:133314894 | chr7:133868486 | ENST00000285928 | 9 | 20 | 194_215 | 404 | 826.0 | Repeat | Note=LRR 4 | |
| Tgene | LRGUK | chr7:133314894 | chr7:133868486 | ENST00000285928 | 9 | 20 | 216_237 | 404 | 826.0 | Repeat | Note=LRR 5 | |
| Tgene | LRGUK | chr7:133314894 | chr7:133868486 | ENST00000285928 | 9 | 20 | 238_259 | 404 | 826.0 | Repeat | Note=LRR 6 | |
| Tgene | LRGUK | chr7:133314894 | chr7:133868486 | ENST00000285928 | 9 | 20 | 260_280 | 404 | 826.0 | Repeat | Note=LRR 7 | |
| Tgene | LRGUK | chr7:133314894 | chr7:133868486 | ENST00000285928 | 9 | 20 | 281_302 | 404 | 826.0 | Repeat | Note=LRR 8 | |
| Tgene | LRGUK | chr7:133314894 | chr7:133868486 | ENST00000285928 | 9 | 20 | 303_324 | 404 | 826.0 | Repeat | Note=LRR 9 | |
| Tgene | LRGUK | chr7:133502297 | chr7:133932308 | ENST00000285928 | 15 | 20 | 129_149 | 661 | 826.0 | Repeat | Note=LRR 1 | |
| Tgene | LRGUK | chr7:133502297 | chr7:133932308 | ENST00000285928 | 15 | 20 | 150_171 | 661 | 826.0 | Repeat | Note=LRR 2 | |
| Tgene | LRGUK | chr7:133502297 | chr7:133932308 | ENST00000285928 | 15 | 20 | 172_193 | 661 | 826.0 | Repeat | Note=LRR 3 | |
| Tgene | LRGUK | chr7:133502297 | chr7:133932308 | ENST00000285928 | 15 | 20 | 194_215 | 661 | 826.0 | Repeat | Note=LRR 4 | |
| Tgene | LRGUK | chr7:133502297 | chr7:133932308 | ENST00000285928 | 15 | 20 | 216_237 | 661 | 826.0 | Repeat | Note=LRR 5 | |
| Tgene | LRGUK | chr7:133502297 | chr7:133932308 | ENST00000285928 | 15 | 20 | 238_259 | 661 | 826.0 | Repeat | Note=LRR 6 | |
| Tgene | LRGUK | chr7:133502297 | chr7:133932308 | ENST00000285928 | 15 | 20 | 260_280 | 661 | 826.0 | Repeat | Note=LRR 7 | |
| Tgene | LRGUK | chr7:133502297 | chr7:133932308 | ENST00000285928 | 15 | 20 | 281_302 | 661 | 826.0 | Repeat | Note=LRR 8 | |
| Tgene | LRGUK | chr7:133502297 | chr7:133932308 | ENST00000285928 | 15 | 20 | 303_324 | 661 | 826.0 | Repeat | Note=LRR 9 |
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Fusion Gene Sequence for EXOC4-LRGUK |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >27905_27905_1_EXOC4-LRGUK_EXOC4_chr7_133314894_ENST00000253861_LRGUK_chr7_133868486_ENST00000285928_length(transcript)=3423nt_BP=1543nt GGAGCCTAGCGGCTCTCCCCGCGTCCAAGATGGCGGCAGAAGCAGCTGGTGGGAAATACAGAAGCACAGTCAGCAAAAGCAAAGACCCCT CGGGGCTGCTCATCTCTGTGATCAGGACTCTGTCTACTAGTGACGATGTCGAAGACAGGGAAAATGAAAAGGGTCGCCTTGAAGAAGCCT ACGAGAAATGTGACCGTGACCTGGATGAATTGATTGTACAGCACTACACAGAATTGACGACAGCCATTCGCACATACCAGAGCATCACAG AGCGCATCACTAACTCCCGAAATAAAATAAAGCAGGTAAAAGAGAACCTGCTTTCATGCAAGATGCTGCTGCACTGCAAACGGGATGAGC TTCGGAAACTGTGGATTGAAGGAATTGAGCATAAGCATGTCCTGAACTTGTTGGATGAAATTGAGAATATCAAGCAAGTGCCTCAAAAGC TGGAACAGTGCATGGCCAGCAAGCACTATCTCAGTGCCACTGACATGTTGGTGTCAGCAGTTGAGTCTTTGGAGGGCCCCCTGCTCCAGG TGGAAGGACTGAGTGACCTTCGACTAGAGCTTCACAGCAAGAAGATGAACCTTCACTTGGTTCTCATAGATGAACTACACCGGCACCTGT ACATCAAATCGACTAGCCGAGTTGTGCAGCGTAACAAGGAAAAAGGGAAAATCAGCTCCCTCGTGAAAGATGCTTCTGTTCCTCTGATTG ATGTTACAAACCTCCCTACTCCTCGAAAATTCCTTGATACCTCTCACTATTCTACTGCTGGAAGCTCAAGTGTGAGGGAGATAAATCTGC AGGACATCAAGGAAGATTTAGAATTGGATCCAGAGGAAAACAGCACCCTGTTTATGGGTATCCTCATTAAGGGCTTGGCGAAACTGAAGA AGATCCCAGAAACAGTTAAGGCAATCATAGAGCGCTTGGAGCAGGAGTTGAAGCAAATTGTGAAGAGGTCTACAACCCAGGTGGCAGACA GTGGCTATCAGCGGGGGGAGAACGTTACTGTGGAGAACCAACCAAGGTTGCTTCTAGAACTGCTGGAGTTACTGTTTGACAAGTTTAATG CTGTAGCCGCTGCACACTCTGTGGTCCTGGGATACCTGCAGGACACTGTAGTGACTCCACTGACTCAGCAGGAAGATATCAAACTGTATG ATATGGCAGATGTATGGGTGAAGATCCAAGATGTTCTACAGATGCTATTAACTGAGTACTTGGATATGAAAAATACTCGTACGGCCTCTG AACCATCAGCTCAACTAAGCTATGCCAGCACTGGACGAGAGTTTGCAGCCTTTTTTGCCAAGAAGAAACCTCAAAGGCCAAAAAATTCTC TTTTCAAGTTCGAATCGTCCTCCCATGCCATCAGTATGAGCGCCTATCTGCGAGAACAGAGAAGGGAGCTCTATAGTCGGAGTGGAGAAC TGCAAGGGGGTCCTGATGACAACTTAATTGAAGGTGGAGGAACAAAATTTGTCTGCAAACCTGGAGCCAGAAACATTACCGTCATATTCC ACCCATTACTAAGCACTCTTCCCAGCCTGGATGCCCCTTATCCCATGCTGATACTAGCTGGTCCTGAAGCTTGTGGGAAACGAGAGCTTG CCCATCGCCTCTGCAGACAGTTTAGCACTTACTTCAGATATGGGGCCTGTCATACCACAAGACCACCTTACTTTGGAGAAGGGGATCGAG TTGATTATCATTTTATCTCTCAAGACGTTTTTGATGAAATGGTGAACATGGGGAAATTCATTCTAACATTTAGTTATGGTAATCACAAGT ATGGATTAAATAGGGACACCGTAGAAGGTATCGCAAGAGATGGTTTGGCAAGCTGTATTCATATGGAAATAGAAGGTGTAAGAAGTTTGA AATATTCCTATTTTGAGCCTCGTTATATCCTGGTGGTGCCCATGAACAAGGAAAAATATGAGGGATATTTGCGGAGAAAAGGATTATTCA GTCGTGCAGAAATTGAATTTGCTGTCTCCAGAGTGGACCTTTATATTAAAATTAATCAGAATTTTCCGGGATATTTTGATGAGGTAATCA ATGCAGATGATCTGGATGTTGCCTACCAAAAACTGAGTCAGCTCATTAGAGAATACCTTGGATTGACTGAGGAACCTGCCAAGAGTTTGG CTACAACTGCAGATGTTAAGACATCCCACCTGAAACCTGAAGCGCATCCTACAAAGTATATTTCTTCGAATATGGGTGATTTCCTGCATT CTACAGACAGAAACTACCTCATTAAATTTTGGGCCAAACTTTCAGCCAAAAAAACACCAGCGGAAAGAGATTCTATACACAGACAGCACG AGGCAGCCCGGCAAGCTCTAATGGGAAGGATACGCCCTGATCACACACTCCTATTTCAAAGGGGTCCAGTACCAGCACCTCTCACCAGTG GTCTACACTATTATACAACTTTAGAAGAACTCTGGAAAAGTTTTGATCTTTGTGAAGACTATTTTAAACCTCCATTTGGACCATATCCTG AAAAGAGTGGGAAGGATTCCTTGGTTTCCATGAAATGTTCATTGTTTCGGTTCTGTCCGTGGTCAAAAGAATTGCCTTTCCAGCCTCCGG AGGGGAGCATTTCTTCACACCTAGGATCAGGAGCCAGTGACAGTGAGACCGAAGAGACCCGGAAAGCACTACCTATACAATCATTTTCAC ATGAAAAAGAGTCTCACCAACACAGACAACACTCGGTCCCAGTCATCAGTCGCCCAGGTTCCAACGTCAAACCCACCCTCCCTCCAATCC CTCAGGGCCGCAGGTAGACTAGCACTTGATGTCTGATCCTAACATGGAAAACCTGCTCTGCTGATGTCGAATTCCTTGCCTTACCTGGCC ATGGGTCCAGCTGTTTCTCACTCAACCCATTACCCACGGAAGAATGTTCTACCTGCCTTAATTCTATCAGCCAGTTTCTCTTGTGATTCT TTGGCTGGTGTCTTTTAGTTTTTTAATTAAAAAATTGTTTCTTAAATGATTTTTAAAGATGTGAGTTTTTTTAATGTGAGTTATTCTTAG CTTTTAAAAATGTCATTTCATTTTTTTTTCTATAGCTATAAATAATTTTTTCCACCTGCTCCCTGCTCGGAAATATCAGATGGAAAAATC TCCCAAGATCTCTGCACCGTGATATGCAGAGTGGCTTTCTGATATATCCAACTGGGATTGTGCTCTTAAAATTTCAATATGTCCATTTAC AACATTCCTGTATGCTCTAGAGGATTGATTTATTTTGCTCTGATTATGAAAGGATTGCAGAGTTCCATTTAACTTGTCGCCAACATGATA TCGACTGCATCTCTCAAAAGGAATTAATGTAATTTTGGGGGGTTCTTGACTTACTTTAGCAACACGAAAGAATAAAGAGCAACAGTTGAT >27905_27905_1_EXOC4-LRGUK_EXOC4_chr7_133314894_ENST00000253861_LRGUK_chr7_133868486_ENST00000285928_length(amino acids)=925AA_BP=0 MAAEAAGGKYRSTVSKSKDPSGLLISVIRTLSTSDDVEDRENEKGRLEEAYEKCDRDLDELIVQHYTELTTAIRTYQSITERITNSRNKI KQVKENLLSCKMLLHCKRDELRKLWIEGIEHKHVLNLLDEIENIKQVPQKLEQCMASKHYLSATDMLVSAVESLEGPLLQVEGLSDLRLE LHSKKMNLHLVLIDELHRHLYIKSTSRVVQRNKEKGKISSLVKDASVPLIDVTNLPTPRKFLDTSHYSTAGSSSVREINLQDIKEDLELD PEENSTLFMGILIKGLAKLKKIPETVKAIIERLEQELKQIVKRSTTQVADSGYQRGENVTVENQPRLLLELLELLFDKFNAVAAAHSVVL GYLQDTVVTPLTQQEDIKLYDMADVWVKIQDVLQMLLTEYLDMKNTRTASEPSAQLSYASTGREFAAFFAKKKPQRPKNSLFKFESSSHA ISMSAYLREQRRELYSRSGELQGGPDDNLIEGGGTKFVCKPGARNITVIFHPLLSTLPSLDAPYPMLILAGPEACGKRELAHRLCRQFST YFRYGACHTTRPPYFGEGDRVDYHFISQDVFDEMVNMGKFILTFSYGNHKYGLNRDTVEGIARDGLASCIHMEIEGVRSLKYSYFEPRYI LVVPMNKEKYEGYLRRKGLFSRAEIEFAVSRVDLYIKINQNFPGYFDEVINADDLDVAYQKLSQLIREYLGLTEEPAKSLATTADVKTSH LKPEAHPTKYISSNMGDFLHSTDRNYLIKFWAKLSAKKTPAERDSIHRQHEAARQALMGRIRPDHTLLFQRGPVPAPLTSGLHYYTTLEE LWKSFDLCEDYFKPPFGPYPEKSGKDSLVSMKCSLFRFCPWSKELPFQPPEGSISSHLGSGASDSETEETRKALPIQSFSHEKESHQHRQ -------------------------------------------------------------- >27905_27905_2_EXOC4-LRGUK_EXOC4_chr7_133314894_ENST00000539845_LRGUK_chr7_133868486_ENST00000285928_length(transcript)=3430nt_BP=1550nt GGGGTTAGCTATAGAGAGAGGAGCCCCGCCTCAGTCTTTTCTTTAGGGGCAGCACCTTCTATTACAGTCTCGGGACCCCAAAGCACGCTA TTTGGGTTTGGTAGAGAAAACCAGGTGTAAAGGACTCTGTCTACTAGTGACGATGTCGAAGACAGGGAAAATGAAAAGGGTCGCCTTGAA GAAGCCTACGAGAAATGTGACCGTGACCTGGATGAATTGATTGTACAGCACTACACAGAATTGACGACAGCCATTCGCACATACCAGAGC ATCACAGAGCGCATCACTAACTCCCGAAATAAAATAAAGCAGGTAAAAGAGAACCTGCTTTCATGCAAGATGCTGCTGCACTGCAAACGG GATGAGCTTCGGAAACTGTGGATTGAAGGAATTGAGCATAAGCATGTCCTGAACTTGTTGGATGAAATTGAGAATATCAAGCAAGTGCCT CAAAAGCTGGAACAGTGCATGGCCAGCAAGCACTATCTCAGTGCCACTGACATGTTGGTGTCAGCAGTTGAGTCTTTGGAGGGCCCCCTG CTCCAGGTGGAAGGACTGAGTGACCTTCGACTAGAGCTTCACAGCAAGAAGATGAACCTTCACTTGGTTCTCATAGATGAACTACACCGG CACCTGTACATCAAATCGACTAGCCGAGTTGTGCAGCGTAACAAGGAAAAAGGGAAAATCAGCTCCCTCGTGAAAGATGCTTCTGTTCCT CTGATTGATGTTACAAACCTCCCTACTCCTCGAAAATTCCTTGATACCTCTCACTATTCTACTGCTGGAAGCTCAAGTGTGAGGGAGATA AATCTGCAGGACATCAAGGAAGATTTAGAATTGGATCCAGAGGAAAACAGCACCCTGTTTATGGGTATCCTCATTAAGGGCTTGGCGAAA CTGAAGAAGATCCCAGAAACAGTTAAGGCAATCATAGAGCGCTTGGAGCAGGAGTTGAAGCAAATTGTGAAGAGGTCTACAACCCAGGTG GCAGACAGTGGCTATCAGCGGGGGGAGAACGTTACTGTGGAGAACCAACCAAGGTTGCTTCTAGAACTGCTGGAGTTACTGTTTGACAAG TTTAATGCTGTAGCCGCTGCACACTCTGTGGTCCTGGGATACCTGCAGGACACTGTAGTGACTCCACTGACTCAGCAGGAAGATATCAAA CTGTATGATATGGCAGATGTATGGGTGAAGATCCAAGATGTTCTACAGATGCTATTAACTGAGTACTTGGATATGAAAAATACTCGTACG GCCTCTGAACCATCAGCTCAACTAAGCTATGCCAGCACTGGACGAGAGTTTGCAGCCTTTTTTGCCAAGAAGAAACCTCAAAGGCCAAAA AATTCTCTTTTCAAGTTCGAATCGTCCTCCCATGCCATCAGTATGAGCGCCTATCTGCGAGAACAGAGAAGGGAGCTCTATAGTCGGAGT GGAGAACTGCAAGGGGGTCCTGATGACAACTTAATTGAAGGTGGAGGAACAAAATTTGTCTGCAAACCTGGAGCCAGAAACATTACCGTC ATATTCCACCCATTACTAAGCACTCTTCCCAGCCTGGATGCCCCTTATCCCATGCTGATACTAGCTGGTCCTGAAGCTTGTGGGAAACGA GAGCTTGCCCATCGCCTCTGCAGACAGTTTAGCACTTACTTCAGATATGGGGCCTGTCATACCACAAGACCACCTTACTTTGGAGAAGGG GATCGAGTTGATTATCATTTTATCTCTCAAGACGTTTTTGATGAAATGGTGAACATGGGGAAATTCATTCTAACATTTAGTTATGGTAAT CACAAGTATGGATTAAATAGGGACACCGTAGAAGGTATCGCAAGAGATGGTTTGGCAAGCTGTATTCATATGGAAATAGAAGGTGTAAGA AGTTTGAAATATTCCTATTTTGAGCCTCGTTATATCCTGGTGGTGCCCATGAACAAGGAAAAATATGAGGGATATTTGCGGAGAAAAGGA TTATTCAGTCGTGCAGAAATTGAATTTGCTGTCTCCAGAGTGGACCTTTATATTAAAATTAATCAGAATTTTCCGGGATATTTTGATGAG GTAATCAATGCAGATGATCTGGATGTTGCCTACCAAAAACTGAGTCAGCTCATTAGAGAATACCTTGGATTGACTGAGGAACCTGCCAAG AGTTTGGCTACAACTGCAGATGTTAAGACATCCCACCTGAAACCTGAAGCGCATCCTACAAAGTATATTTCTTCGAATATGGGTGATTTC CTGCATTCTACAGACAGAAACTACCTCATTAAATTTTGGGCCAAACTTTCAGCCAAAAAAACACCAGCGGAAAGAGATTCTATACACAGA CAGCACGAGGCAGCCCGGCAAGCTCTAATGGGAAGGATACGCCCTGATCACACACTCCTATTTCAAAGGGGTCCAGTACCAGCACCTCTC ACCAGTGGTCTACACTATTATACAACTTTAGAAGAACTCTGGAAAAGTTTTGATCTTTGTGAAGACTATTTTAAACCTCCATTTGGACCA TATCCTGAAAAGAGTGGGAAGGATTCCTTGGTTTCCATGAAATGTTCATTGTTTCGGTTCTGTCCGTGGTCAAAAGAATTGCCTTTCCAG CCTCCGGAGGGGAGCATTTCTTCACACCTAGGATCAGGAGCCAGTGACAGTGAGACCGAAGAGACCCGGAAAGCACTACCTATACAATCA TTTTCACATGAAAAAGAGTCTCACCAACACAGACAACACTCGGTCCCAGTCATCAGTCGCCCAGGTTCCAACGTCAAACCCACCCTCCCT CCAATCCCTCAGGGCCGCAGGTAGACTAGCACTTGATGTCTGATCCTAACATGGAAAACCTGCTCTGCTGATGTCGAATTCCTTGCCTTA CCTGGCCATGGGTCCAGCTGTTTCTCACTCAACCCATTACCCACGGAAGAATGTTCTACCTGCCTTAATTCTATCAGCCAGTTTCTCTTG TGATTCTTTGGCTGGTGTCTTTTAGTTTTTTAATTAAAAAATTGTTTCTTAAATGATTTTTAAAGATGTGAGTTTTTTTAATGTGAGTTA TTCTTAGCTTTTAAAAATGTCATTTCATTTTTTTTTCTATAGCTATAAATAATTTTTTCCACCTGCTCCCTGCTCGGAAATATCAGATGG AAAAATCTCCCAAGATCTCTGCACCGTGATATGCAGAGTGGCTTTCTGATATATCCAACTGGGATTGTGCTCTTAAAATTTCAATATGTC CATTTACAACATTCCTGTATGCTCTAGAGGATTGATTTATTTTGCTCTGATTATGAAAGGATTGCAGAGTTCCATTTAACTTGTCGCCAA CATGATATCGACTGCATCTCTCAAAAGGAATTAATGTAATTTTGGGGGGTTCTTGACTTACTTTAGCAACACGAAAGAATAAAGAGCAAC >27905_27905_2_EXOC4-LRGUK_EXOC4_chr7_133314894_ENST00000539845_LRGUK_chr7_133868486_ENST00000285928_length(amino acids)=895AA_BP=1 MSTSDDVEDRENEKGRLEEAYEKCDRDLDELIVQHYTELTTAIRTYQSITERITNSRNKIKQVKENLLSCKMLLHCKRDELRKLWIEGIE HKHVLNLLDEIENIKQVPQKLEQCMASKHYLSATDMLVSAVESLEGPLLQVEGLSDLRLELHSKKMNLHLVLIDELHRHLYIKSTSRVVQ RNKEKGKISSLVKDASVPLIDVTNLPTPRKFLDTSHYSTAGSSSVREINLQDIKEDLELDPEENSTLFMGILIKGLAKLKKIPETVKAII ERLEQELKQIVKRSTTQVADSGYQRGENVTVENQPRLLLELLELLFDKFNAVAAAHSVVLGYLQDTVVTPLTQQEDIKLYDMADVWVKIQ DVLQMLLTEYLDMKNTRTASEPSAQLSYASTGREFAAFFAKKKPQRPKNSLFKFESSSHAISMSAYLREQRRELYSRSGELQGGPDDNLI EGGGTKFVCKPGARNITVIFHPLLSTLPSLDAPYPMLILAGPEACGKRELAHRLCRQFSTYFRYGACHTTRPPYFGEGDRVDYHFISQDV FDEMVNMGKFILTFSYGNHKYGLNRDTVEGIARDGLASCIHMEIEGVRSLKYSYFEPRYILVVPMNKEKYEGYLRRKGLFSRAEIEFAVS RVDLYIKINQNFPGYFDEVINADDLDVAYQKLSQLIREYLGLTEEPAKSLATTADVKTSHLKPEAHPTKYISSNMGDFLHSTDRNYLIKF WAKLSAKKTPAERDSIHRQHEAARQALMGRIRPDHTLLFQRGPVPAPLTSGLHYYTTLEELWKSFDLCEDYFKPPFGPYPEKSGKDSLVS -------------------------------------------------------------- >27905_27905_3_EXOC4-LRGUK_EXOC4_chr7_133314894_ENST00000545148_LRGUK_chr7_133868486_ENST00000285928_length(transcript)=2277nt_BP=397nt TTTATAGAGGGCATCTGTCGGTTGCATTTGATTTATTTAAAACGTTTTCTTACATGGCCAATTTAGTAACAGCAAGCAAAACCAAAATGA GCAAAGGAGAGGATCCCAATAATCCCAGATCTATAAAGCGGATTTCTCAAGGGGGTAGAGATAACCACCTAGCTATTGCTAAATGTGATC TCACTCAGTTGAAAAAGAAACAATCAGAAGTGAGCAATGGGAGCCGTGAAACCATCTCAATGAAGACTTGTTGCCAACATGGAGATAGAG GATATTGGTCTACAGGGTACTATTGGAGAGGGGGTCCTGATGACAACTTAATTGAAGGTGGAGGAACAAAATTTGTCTGCAAACCTGGAG CCAGAAACATTACCGTCATATTCCACCCATTACTAAGCACTCTTCCCAGCCTGGATGCCCCTTATCCCATGCTGATACTAGCTGGTCCTG AAGCTTGTGGGAAACGAGAGCTTGCCCATCGCCTCTGCAGACAGTTTAGCACTTACTTCAGATATGGGGCCTGTCATACCACAAGACCAC CTTACTTTGGAGAAGGGGATCGAGTTGATTATCATTTTATCTCTCAAGACGTTTTTGATGAAATGGTGAACATGGGGAAATTCATTCTAA CATTTAGTTATGGTAATCACAAGTATGGATTAAATAGGGACACCGTAGAAGGTATCGCAAGAGATGGTTTGGCAAGCTGTATTCATATGG AAATAGAAGGTGTAAGAAGTTTGAAATATTCCTATTTTGAGCCTCGTTATATCCTGGTGGTGCCCATGAACAAGGAAAAATATGAGGGAT ATTTGCGGAGAAAAGGATTATTCAGTCGTGCAGAAATTGAATTTGCTGTCTCCAGAGTGGACCTTTATATTAAAATTAATCAGAATTTTC CGGGATATTTTGATGAGGTAATCAATGCAGATGATCTGGATGTTGCCTACCAAAAACTGAGTCAGCTCATTAGAGAATACCTTGGATTGA CTGAGGAACCTGCCAAGAGTTTGGCTACAACTGCAGATGTTAAGACATCCCACCTGAAACCTGAAGCGCATCCTACAAAGTATATTTCTT CGAATATGGGTGATTTCCTGCATTCTACAGACAGAAACTACCTCATTAAATTTTGGGCCAAACTTTCAGCCAAAAAAACACCAGCGGAAA GAGATTCTATACACAGACAGCACGAGGCAGCCCGGCAAGCTCTAATGGGAAGGATACGCCCTGATCACACACTCCTATTTCAAAGGGGTC CAGTACCAGCACCTCTCACCAGTGGTCTACACTATTATACAACTTTAGAAGAACTCTGGAAAAGTTTTGATCTTTGTGAAGACTATTTTA AACCTCCATTTGGACCATATCCTGAAAAGAGTGGGAAGGATTCCTTGGTTTCCATGAAATGTTCATTGTTTCGGTTCTGTCCGTGGTCAA AAGAATTGCCTTTCCAGCCTCCGGAGGGGAGCATTTCTTCACACCTAGGATCAGGAGCCAGTGACAGTGAGACCGAAGAGACCCGGAAAG CACTACCTATACAATCATTTTCACATGAAAAAGAGTCTCACCAACACAGACAACACTCGGTCCCAGTCATCAGTCGCCCAGGTTCCAACG TCAAACCCACCCTCCCTCCAATCCCTCAGGGCCGCAGGTAGACTAGCACTTGATGTCTGATCCTAACATGGAAAACCTGCTCTGCTGATG TCGAATTCCTTGCCTTACCTGGCCATGGGTCCAGCTGTTTCTCACTCAACCCATTACCCACGGAAGAATGTTCTACCTGCCTTAATTCTA TCAGCCAGTTTCTCTTGTGATTCTTTGGCTGGTGTCTTTTAGTTTTTTAATTAAAAAATTGTTTCTTAAATGATTTTTAAAGATGTGAGT TTTTTTAATGTGAGTTATTCTTAGCTTTTAAAAATGTCATTTCATTTTTTTTTCTATAGCTATAAATAATTTTTTCCACCTGCTCCCTGC TCGGAAATATCAGATGGAAAAATCTCCCAAGATCTCTGCACCGTGATATGCAGAGTGGCTTTCTGATATATCCAACTGGGATTGTGCTCT TAAAATTTCAATATGTCCATTTACAACATTCCTGTATGCTCTAGAGGATTGATTTATTTTGCTCTGATTATGAAAGGATTGCAGAGTTCC ATTTAACTTGTCGCCAACATGATATCGACTGCATCTCTCAAAAGGAATTAATGTAATTTTGGGGGGTTCTTGACTTACTTTAGCAACACG >27905_27905_3_EXOC4-LRGUK_EXOC4_chr7_133314894_ENST00000545148_LRGUK_chr7_133868486_ENST00000285928_length(amino acids)=548AA_BP=1 MSVAFDLFKTFSYMANLVTASKTKMSKGEDPNNPRSIKRISQGGRDNHLAIAKCDLTQLKKKQSEVSNGSRETISMKTCCQHGDRGYWST GYYWRGGPDDNLIEGGGTKFVCKPGARNITVIFHPLLSTLPSLDAPYPMLILAGPEACGKRELAHRLCRQFSTYFRYGACHTTRPPYFGE GDRVDYHFISQDVFDEMVNMGKFILTFSYGNHKYGLNRDTVEGIARDGLASCIHMEIEGVRSLKYSYFEPRYILVVPMNKEKYEGYLRRK GLFSRAEIEFAVSRVDLYIKINQNFPGYFDEVINADDLDVAYQKLSQLIREYLGLTEEPAKSLATTADVKTSHLKPEAHPTKYISSNMGD FLHSTDRNYLIKFWAKLSAKKTPAERDSIHRQHEAARQALMGRIRPDHTLLFQRGPVPAPLTSGLHYYTTLEELWKSFDLCEDYFKPPFG PYPEKSGKDSLVSMKCSLFRFCPWSKELPFQPPEGSISSHLGSGASDSETEETRKALPIQSFSHEKESHQHRQHSVPVISRPGSNVKPTL -------------------------------------------------------------- >27905_27905_4_EXOC4-LRGUK_EXOC4_chr7_133502297_ENST00000253861_LRGUK_chr7_133932308_ENST00000285928_length(transcript)=2874nt_BP=1763nt GGAGCCTAGCGGCTCTCCCCGCGTCCAAGATGGCGGCAGAAGCAGCTGGTGGGAAATACAGAAGCACAGTCAGCAAAAGCAAAGACCCCT CGGGGCTGCTCATCTCTGTGATCAGGACTCTGTCTACTAGTGACGATGTCGAAGACAGGGAAAATGAAAAGGGTCGCCTTGAAGAAGCCT ACGAGAAATGTGACCGTGACCTGGATGAATTGATTGTACAGCACTACACAGAATTGACGACAGCCATTCGCACATACCAGAGCATCACAG AGCGCATCACTAACTCCCGAAATAAAATAAAGCAGGTAAAAGAGAACCTGCTTTCATGCAAGATGCTGCTGCACTGCAAACGGGATGAGC TTCGGAAACTGTGGATTGAAGGAATTGAGCATAAGCATGTCCTGAACTTGTTGGATGAAATTGAGAATATCAAGCAAGTGCCTCAAAAGC TGGAACAGTGCATGGCCAGCAAGCACTATCTCAGTGCCACTGACATGTTGGTGTCAGCAGTTGAGTCTTTGGAGGGCCCCCTGCTCCAGG TGGAAGGACTGAGTGACCTTCGACTAGAGCTTCACAGCAAGAAGATGAACCTTCACTTGGTTCTCATAGATGAACTACACCGGCACCTGT ACATCAAATCGACTAGCCGAGTTGTGCAGCGTAACAAGGAAAAAGGGAAAATCAGCTCCCTCGTGAAAGATGCTTCTGTTCCTCTGATTG ATGTTACAAACCTCCCTACTCCTCGAAAATTCCTTGATACCTCTCACTATTCTACTGCTGGAAGCTCAAGTGTGAGGGAGATAAATCTGC AGGACATCAAGGAAGATTTAGAATTGGATCCAGAGGAAAACAGCACCCTGTTTATGGGTATCCTCATTAAGGGCTTGGCGAAACTGAAGA AGATCCCAGAAACAGTTAAGGCAATCATAGAGCGCTTGGAGCAGGAGTTGAAGCAAATTGTGAAGAGGTCTACAACCCAGGTGGCAGACA GTGGCTATCAGCGGGGGGAGAACGTTACTGTGGAGAACCAACCAAGGTTGCTTCTAGAACTGCTGGAGTTACTGTTTGACAAGTTTAATG CTGTAGCCGCTGCACACTCTGTGGTCCTGGGATACCTGCAGGACACTGTAGTGACTCCACTGACTCAGCAGGAAGATATCAAACTGTATG ATATGGCAGATGTATGGGTGAAGATCCAAGATGTTCTACAGATGCTATTAACTGAGTACTTGGATATGAAAAATACTCGTACGGCCTCTG AACCATCAGCTCAACTAAGCTATGCCAGCACTGGACGAGAGTTTGCAGCCTTTTTTGCCAAGAAGAAACCTCAAAGGCCAAAAAATTCTC TTTTCAAGTTCGAATCGTCCTCCCATGCCATCAGTATGAGCGCCTATCTGCGAGAACAGAGAAGGGAGCTCTATAGTCGGAGTGGAGAAC TGCAAGGGGGTCCTGATGACAACTTAATTGAAGGTGGAGGAACAAAATTTGTCTGCAAACCTGGAGCCAGAAACATTACCGTCATATTCC ACCCATTACTAAGATTTATTCAGGAGATTGAGCATGCTCTGGGTCTTGGCCCAGCCAAACAGTGTCCTCTTCGAGAGTTTCTCACCGTGT ACATCAAAAACATCTTTCTCAATCAAGTCTTGGCTGAGATCAACAAGGAGATTGAAGGAGTCACTAAAACATCTGACCCTTTGAAGATTC TGGCCAACGCAGACACCATGAAGGTGCTGGGAGTGCAGCGGCCTCTCCTACAGGAAAGAGATTCTATACACAGACAGCACGAGGCAGCCC GGCAAGCTCTAATGGGAAGGATACGCCCTGATCACACACTCCTATTTCAAAGGGGTCCAGTACCAGCACCTCTCACCAGTGGTCTACACT ATTATACAACTTTAGAAGAACTCTGGAAAAGTTTTGATCTTTGTGAAGACTATTTTAAACCTCCATTTGGACCATATCCTGAAAAGAGTG GGAAGGATTCCTTGGTTTCCATGAAATGTTCATTGTTTCGGTTCTGTCCGTGGTCAAAAGAATTGCCTTTCCAGCCTCCGGAGGGGAGCA TTTCTTCACACCTAGGATCAGGAGCCAGTGACAGTGAGACCGAAGAGACCCGGAAAGCACTACCTATACAATCATTTTCACATGAAAAAG AGTCTCACCAACACAGACAACACTCGGTCCCAGTCATCAGTCGCCCAGGTTCCAACGTCAAACCCACCCTCCCTCCAATCCCTCAGGGCC GCAGGTAGACTAGCACTTGATGTCTGATCCTAACATGGAAAACCTGCTCTGCTGATGTCGAATTCCTTGCCTTACCTGGCCATGGGTCCA GCTGTTTCTCACTCAACCCATTACCCACGGAAGAATGTTCTACCTGCCTTAATTCTATCAGCCAGTTTCTCTTGTGATTCTTTGGCTGGT GTCTTTTAGTTTTTTAATTAAAAAATTGTTTCTTAAATGATTTTTAAAGATGTGAGTTTTTTTAATGTGAGTTATTCTTAGCTTTTAAAA ATGTCATTTCATTTTTTTTTCTATAGCTATAAATAATTTTTTCCACCTGCTCCCTGCTCGGAAATATCAGATGGAAAAATCTCCCAAGAT CTCTGCACCGTGATATGCAGAGTGGCTTTCTGATATATCCAACTGGGATTGTGCTCTTAAAATTTCAATATGTCCATTTACAACATTCCT GTATGCTCTAGAGGATTGATTTATTTTGCTCTGATTATGAAAGGATTGCAGAGTTCCATTTAACTTGTCGCCAACATGATATCGACTGCA >27905_27905_4_EXOC4-LRGUK_EXOC4_chr7_133502297_ENST00000253861_LRGUK_chr7_133932308_ENST00000285928_length(amino acids)=742AA_BP=0 MAAEAAGGKYRSTVSKSKDPSGLLISVIRTLSTSDDVEDRENEKGRLEEAYEKCDRDLDELIVQHYTELTTAIRTYQSITERITNSRNKI KQVKENLLSCKMLLHCKRDELRKLWIEGIEHKHVLNLLDEIENIKQVPQKLEQCMASKHYLSATDMLVSAVESLEGPLLQVEGLSDLRLE LHSKKMNLHLVLIDELHRHLYIKSTSRVVQRNKEKGKISSLVKDASVPLIDVTNLPTPRKFLDTSHYSTAGSSSVREINLQDIKEDLELD PEENSTLFMGILIKGLAKLKKIPETVKAIIERLEQELKQIVKRSTTQVADSGYQRGENVTVENQPRLLLELLELLFDKFNAVAAAHSVVL GYLQDTVVTPLTQQEDIKLYDMADVWVKIQDVLQMLLTEYLDMKNTRTASEPSAQLSYASTGREFAAFFAKKKPQRPKNSLFKFESSSHA ISMSAYLREQRRELYSRSGELQGGPDDNLIEGGGTKFVCKPGARNITVIFHPLLRFIQEIEHALGLGPAKQCPLREFLTVYIKNIFLNQV LAEINKEIEGVTKTSDPLKILANADTMKVLGVQRPLLQERDSIHRQHEAARQALMGRIRPDHTLLFQRGPVPAPLTSGLHYYTTLEELWK SFDLCEDYFKPPFGPYPEKSGKDSLVSMKCSLFRFCPWSKELPFQPPEGSISSHLGSGASDSETEETRKALPIQSFSHEKESHQHRQHSV -------------------------------------------------------------- >27905_27905_5_EXOC4-LRGUK_EXOC4_chr7_133502297_ENST00000539845_LRGUK_chr7_133932308_ENST00000285928_length(transcript)=2881nt_BP=1770nt GGGGTTAGCTATAGAGAGAGGAGCCCCGCCTCAGTCTTTTCTTTAGGGGCAGCACCTTCTATTACAGTCTCGGGACCCCAAAGCACGCTA TTTGGGTTTGGTAGAGAAAACCAGGTGTAAAGGACTCTGTCTACTAGTGACGATGTCGAAGACAGGGAAAATGAAAAGGGTCGCCTTGAA GAAGCCTACGAGAAATGTGACCGTGACCTGGATGAATTGATTGTACAGCACTACACAGAATTGACGACAGCCATTCGCACATACCAGAGC ATCACAGAGCGCATCACTAACTCCCGAAATAAAATAAAGCAGGTAAAAGAGAACCTGCTTTCATGCAAGATGCTGCTGCACTGCAAACGG GATGAGCTTCGGAAACTGTGGATTGAAGGAATTGAGCATAAGCATGTCCTGAACTTGTTGGATGAAATTGAGAATATCAAGCAAGTGCCT CAAAAGCTGGAACAGTGCATGGCCAGCAAGCACTATCTCAGTGCCACTGACATGTTGGTGTCAGCAGTTGAGTCTTTGGAGGGCCCCCTG CTCCAGGTGGAAGGACTGAGTGACCTTCGACTAGAGCTTCACAGCAAGAAGATGAACCTTCACTTGGTTCTCATAGATGAACTACACCGG CACCTGTACATCAAATCGACTAGCCGAGTTGTGCAGCGTAACAAGGAAAAAGGGAAAATCAGCTCCCTCGTGAAAGATGCTTCTGTTCCT CTGATTGATGTTACAAACCTCCCTACTCCTCGAAAATTCCTTGATACCTCTCACTATTCTACTGCTGGAAGCTCAAGTGTGAGGGAGATA AATCTGCAGGACATCAAGGAAGATTTAGAATTGGATCCAGAGGAAAACAGCACCCTGTTTATGGGTATCCTCATTAAGGGCTTGGCGAAA CTGAAGAAGATCCCAGAAACAGTTAAGGCAATCATAGAGCGCTTGGAGCAGGAGTTGAAGCAAATTGTGAAGAGGTCTACAACCCAGGTG GCAGACAGTGGCTATCAGCGGGGGGAGAACGTTACTGTGGAGAACCAACCAAGGTTGCTTCTAGAACTGCTGGAGTTACTGTTTGACAAG TTTAATGCTGTAGCCGCTGCACACTCTGTGGTCCTGGGATACCTGCAGGACACTGTAGTGACTCCACTGACTCAGCAGGAAGATATCAAA CTGTATGATATGGCAGATGTATGGGTGAAGATCCAAGATGTTCTACAGATGCTATTAACTGAGTACTTGGATATGAAAAATACTCGTACG GCCTCTGAACCATCAGCTCAACTAAGCTATGCCAGCACTGGACGAGAGTTTGCAGCCTTTTTTGCCAAGAAGAAACCTCAAAGGCCAAAA AATTCTCTTTTCAAGTTCGAATCGTCCTCCCATGCCATCAGTATGAGCGCCTATCTGCGAGAACAGAGAAGGGAGCTCTATAGTCGGAGT GGAGAACTGCAAGGGGGTCCTGATGACAACTTAATTGAAGGTGGAGGAACAAAATTTGTCTGCAAACCTGGAGCCAGAAACATTACCGTC ATATTCCACCCATTACTAAGATTTATTCAGGAGATTGAGCATGCTCTGGGTCTTGGCCCAGCCAAACAGTGTCCTCTTCGAGAGTTTCTC ACCGTGTACATCAAAAACATCTTTCTCAATCAAGTCTTGGCTGAGATCAACAAGGAGATTGAAGGAGTCACTAAAACATCTGACCCTTTG AAGATTCTGGCCAACGCAGACACCATGAAGGTGCTGGGAGTGCAGCGGCCTCTCCTACAGGAAAGAGATTCTATACACAGACAGCACGAG GCAGCCCGGCAAGCTCTAATGGGAAGGATACGCCCTGATCACACACTCCTATTTCAAAGGGGTCCAGTACCAGCACCTCTCACCAGTGGT CTACACTATTATACAACTTTAGAAGAACTCTGGAAAAGTTTTGATCTTTGTGAAGACTATTTTAAACCTCCATTTGGACCATATCCTGAA AAGAGTGGGAAGGATTCCTTGGTTTCCATGAAATGTTCATTGTTTCGGTTCTGTCCGTGGTCAAAAGAATTGCCTTTCCAGCCTCCGGAG GGGAGCATTTCTTCACACCTAGGATCAGGAGCCAGTGACAGTGAGACCGAAGAGACCCGGAAAGCACTACCTATACAATCATTTTCACAT GAAAAAGAGTCTCACCAACACAGACAACACTCGGTCCCAGTCATCAGTCGCCCAGGTTCCAACGTCAAACCCACCCTCCCTCCAATCCCT CAGGGCCGCAGGTAGACTAGCACTTGATGTCTGATCCTAACATGGAAAACCTGCTCTGCTGATGTCGAATTCCTTGCCTTACCTGGCCAT GGGTCCAGCTGTTTCTCACTCAACCCATTACCCACGGAAGAATGTTCTACCTGCCTTAATTCTATCAGCCAGTTTCTCTTGTGATTCTTT GGCTGGTGTCTTTTAGTTTTTTAATTAAAAAATTGTTTCTTAAATGATTTTTAAAGATGTGAGTTTTTTTAATGTGAGTTATTCTTAGCT TTTAAAAATGTCATTTCATTTTTTTTTCTATAGCTATAAATAATTTTTTCCACCTGCTCCCTGCTCGGAAATATCAGATGGAAAAATCTC CCAAGATCTCTGCACCGTGATATGCAGAGTGGCTTTCTGATATATCCAACTGGGATTGTGCTCTTAAAATTTCAATATGTCCATTTACAA CATTCCTGTATGCTCTAGAGGATTGATTTATTTTGCTCTGATTATGAAAGGATTGCAGAGTTCCATTTAACTTGTCGCCAACATGATATC GACTGCATCTCTCAAAAGGAATTAATGTAATTTTGGGGGGTTCTTGACTTACTTTAGCAACACGAAAGAATAAAGAGCAACAGTTGATTC >27905_27905_5_EXOC4-LRGUK_EXOC4_chr7_133502297_ENST00000539845_LRGUK_chr7_133932308_ENST00000285928_length(amino acids)=712AA_BP=1 MSTSDDVEDRENEKGRLEEAYEKCDRDLDELIVQHYTELTTAIRTYQSITERITNSRNKIKQVKENLLSCKMLLHCKRDELRKLWIEGIE HKHVLNLLDEIENIKQVPQKLEQCMASKHYLSATDMLVSAVESLEGPLLQVEGLSDLRLELHSKKMNLHLVLIDELHRHLYIKSTSRVVQ RNKEKGKISSLVKDASVPLIDVTNLPTPRKFLDTSHYSTAGSSSVREINLQDIKEDLELDPEENSTLFMGILIKGLAKLKKIPETVKAII ERLEQELKQIVKRSTTQVADSGYQRGENVTVENQPRLLLELLELLFDKFNAVAAAHSVVLGYLQDTVVTPLTQQEDIKLYDMADVWVKIQ DVLQMLLTEYLDMKNTRTASEPSAQLSYASTGREFAAFFAKKKPQRPKNSLFKFESSSHAISMSAYLREQRRELYSRSGELQGGPDDNLI EGGGTKFVCKPGARNITVIFHPLLRFIQEIEHALGLGPAKQCPLREFLTVYIKNIFLNQVLAEINKEIEGVTKTSDPLKILANADTMKVL GVQRPLLQERDSIHRQHEAARQALMGRIRPDHTLLFQRGPVPAPLTSGLHYYTTLEELWKSFDLCEDYFKPPFGPYPEKSGKDSLVSMKC -------------------------------------------------------------- >27905_27905_6_EXOC4-LRGUK_EXOC4_chr7_133502297_ENST00000545148_LRGUK_chr7_133932308_ENST00000285928_length(transcript)=1728nt_BP=617nt TTTATAGAGGGCATCTGTCGGTTGCATTTGATTTATTTAAAACGTTTTCTTACATGGCCAATTTAGTAACAGCAAGCAAAACCAAAATGA GCAAAGGAGAGGATCCCAATAATCCCAGATCTATAAAGCGGATTTCTCAAGGGGGTAGAGATAACCACCTAGCTATTGCTAAATGTGATC TCACTCAGTTGAAAAAGAAACAATCAGAAGTGAGCAATGGGAGCCGTGAAACCATCTCAATGAAGACTTGTTGCCAACATGGAGATAGAG GATATTGGTCTACAGGGTACTATTGGAGAGGGGGTCCTGATGACAACTTAATTGAAGGTGGAGGAACAAAATTTGTCTGCAAACCTGGAG CCAGAAACATTACCGTCATATTCCACCCATTACTAAGATTTATTCAGGAGATTGAGCATGCTCTGGGTCTTGGCCCAGCCAAACAGTGTC CTCTTCGAGAGTTTCTCACCGTGTACATCAAAAACATCTTTCTCAATCAAGTCTTGGCTGAGATCAACAAGGAGATTGAAGGAGTCACTA AAACATCTGACCCTTTGAAGATTCTGGCCAACGCAGACACCATGAAGGTGCTGGGAGTGCAGCGGCCTCTCCTACAGGAAAGAGATTCTA TACACAGACAGCACGAGGCAGCCCGGCAAGCTCTAATGGGAAGGATACGCCCTGATCACACACTCCTATTTCAAAGGGGTCCAGTACCAG CACCTCTCACCAGTGGTCTACACTATTATACAACTTTAGAAGAACTCTGGAAAAGTTTTGATCTTTGTGAAGACTATTTTAAACCTCCAT TTGGACCATATCCTGAAAAGAGTGGGAAGGATTCCTTGGTTTCCATGAAATGTTCATTGTTTCGGTTCTGTCCGTGGTCAAAAGAATTGC CTTTCCAGCCTCCGGAGGGGAGCATTTCTTCACACCTAGGATCAGGAGCCAGTGACAGTGAGACCGAAGAGACCCGGAAAGCACTACCTA TACAATCATTTTCACATGAAAAAGAGTCTCACCAACACAGACAACACTCGGTCCCAGTCATCAGTCGCCCAGGTTCCAACGTCAAACCCA CCCTCCCTCCAATCCCTCAGGGCCGCAGGTAGACTAGCACTTGATGTCTGATCCTAACATGGAAAACCTGCTCTGCTGATGTCGAATTCC TTGCCTTACCTGGCCATGGGTCCAGCTGTTTCTCACTCAACCCATTACCCACGGAAGAATGTTCTACCTGCCTTAATTCTATCAGCCAGT TTCTCTTGTGATTCTTTGGCTGGTGTCTTTTAGTTTTTTAATTAAAAAATTGTTTCTTAAATGATTTTTAAAGATGTGAGTTTTTTTAAT GTGAGTTATTCTTAGCTTTTAAAAATGTCATTTCATTTTTTTTTCTATAGCTATAAATAATTTTTTCCACCTGCTCCCTGCTCGGAAATA TCAGATGGAAAAATCTCCCAAGATCTCTGCACCGTGATATGCAGAGTGGCTTTCTGATATATCCAACTGGGATTGTGCTCTTAAAATTTC AATATGTCCATTTACAACATTCCTGTATGCTCTAGAGGATTGATTTATTTTGCTCTGATTATGAAAGGATTGCAGAGTTCCATTTAACTT GTCGCCAACATGATATCGACTGCATCTCTCAAAAGGAATTAATGTAATTTTGGGGGGTTCTTGACTTACTTTAGCAACACGAAAGAATAA >27905_27905_6_EXOC4-LRGUK_EXOC4_chr7_133502297_ENST00000545148_LRGUK_chr7_133932308_ENST00000285928_length(amino acids)=365AA_BP=1 MSVAFDLFKTFSYMANLVTASKTKMSKGEDPNNPRSIKRISQGGRDNHLAIAKCDLTQLKKKQSEVSNGSRETISMKTCCQHGDRGYWST GYYWRGGPDDNLIEGGGTKFVCKPGARNITVIFHPLLRFIQEIEHALGLGPAKQCPLREFLTVYIKNIFLNQVLAEINKEIEGVTKTSDP LKILANADTMKVLGVQRPLLQERDSIHRQHEAARQALMGRIRPDHTLLFQRGPVPAPLTSGLHYYTTLEELWKSFDLCEDYFKPPFGPYP EKSGKDSLVSMKCSLFRFCPWSKELPFQPPEGSISSHLGSGASDSETEETRKALPIQSFSHEKESHQHRQHSVPVISRPGSNVKPTLPPI -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for EXOC4-LRGUK |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for EXOC4-LRGUK |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for EXOC4-LRGUK |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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