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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:EXOC4-TRUB2 (FusionGDB2 ID:27922)

Fusion Gene Summary for EXOC4-TRUB2

check button Fusion gene summary
Fusion gene informationFusion gene name: EXOC4-TRUB2
Fusion gene ID: 27922
HgeneTgene
Gene symbol

EXOC4

TRUB2

Gene ID

60412

26995

Gene nameexocyst complex component 4TruB pseudouridine synthase family member 2
SynonymsSEC8|SEC8L1|Sec8pCLONE24922
Cytomap

7q33

9q34.11

Type of geneprotein-codingprotein-coding
Descriptionexocyst complex component 4SEC8-like 1exocyst complex component Sec8mitochondrial mRNA pseudouridine synthase TRUB2TruB pseudouridine (psi) synthase family member 2TruB pseudouridine (psi) synthase homolog 2probable tRNA pseudouridine synthase 2
Modification date2020032020200313
UniProtAcc

Q96A65

.
Ensembl transtripts involved in fusion geneENST00000253861, ENST00000393161, 
ENST00000539845, ENST00000460346, 
ENST00000541309, ENST00000545148, 
ENST00000460320, ENST00000372890, 
ENST00000546104, 
Fusion gene scores* DoF score29 X 25 X 11=79753 X 3 X 3=27
# samples 303
** MAII scorelog2(30/7975*10)=-4.73245011304371
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: EXOC4 [Title/Abstract] AND TRUB2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointEXOC4(133164892)-TRUB2(131079505), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across EXOC4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TRUB2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-09-2045-01AEXOC4chr7

133164892

+TRUB2chr9

131079505

-
ChimerDB4OVTCGA-09-2045EXOC4chr7

133164892

+TRUB2chr9

131079505

-


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Fusion Gene ORF analysis for EXOC4-TRUB2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000253861ENST00000460320EXOC4chr7

133164892

+TRUB2chr9

131079505

-
5CDS-5UTRENST00000393161ENST00000460320EXOC4chr7

133164892

+TRUB2chr9

131079505

-
5CDS-5UTRENST00000539845ENST00000460320EXOC4chr7

133164892

+TRUB2chr9

131079505

-
In-frameENST00000253861ENST00000372890EXOC4chr7

133164892

+TRUB2chr9

131079505

-
In-frameENST00000253861ENST00000546104EXOC4chr7

133164892

+TRUB2chr9

131079505

-
In-frameENST00000393161ENST00000372890EXOC4chr7

133164892

+TRUB2chr9

131079505

-
In-frameENST00000393161ENST00000546104EXOC4chr7

133164892

+TRUB2chr9

131079505

-
In-frameENST00000539845ENST00000372890EXOC4chr7

133164892

+TRUB2chr9

131079505

-
In-frameENST00000539845ENST00000546104EXOC4chr7

133164892

+TRUB2chr9

131079505

-
intron-3CDSENST00000460346ENST00000372890EXOC4chr7

133164892

+TRUB2chr9

131079505

-
intron-3CDSENST00000460346ENST00000546104EXOC4chr7

133164892

+TRUB2chr9

131079505

-
intron-3CDSENST00000541309ENST00000372890EXOC4chr7

133164892

+TRUB2chr9

131079505

-
intron-3CDSENST00000541309ENST00000546104EXOC4chr7

133164892

+TRUB2chr9

131079505

-
intron-3CDSENST00000545148ENST00000372890EXOC4chr7

133164892

+TRUB2chr9

131079505

-
intron-3CDSENST00000545148ENST00000546104EXOC4chr7

133164892

+TRUB2chr9

131079505

-
intron-5UTRENST00000460346ENST00000460320EXOC4chr7

133164892

+TRUB2chr9

131079505

-
intron-5UTRENST00000541309ENST00000460320EXOC4chr7

133164892

+TRUB2chr9

131079505

-
intron-5UTRENST00000545148ENST00000460320EXOC4chr7

133164892

+TRUB2chr9

131079505

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000253861EXOC4chr7133164892+ENST00000372890TRUB2chr9131079505-26481446292200723
ENST00000253861EXOC4chr7133164892+ENST00000546104TRUB2chr9131079505-25571446292200723
ENST00000539845EXOC4chr7133164892+ENST00000372890TRUB2chr9131079505-265514531262207693
ENST00000539845EXOC4chr7133164892+ENST00000546104TRUB2chr9131079505-256414531262207693
ENST00000393161EXOC4chr7133164892+ENST00000372890TRUB2chr9131079505-26481446292200723
ENST00000393161EXOC4chr7133164892+ENST00000546104TRUB2chr9131079505-25571446292200723

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000253861ENST00000372890EXOC4chr7133164892+TRUB2chr9131079505-0.0098158870.9901841
ENST00000253861ENST00000546104EXOC4chr7133164892+TRUB2chr9131079505-0.0128990660.98710096
ENST00000539845ENST00000372890EXOC4chr7133164892+TRUB2chr9131079505-0.0162249670.98377496
ENST00000539845ENST00000546104EXOC4chr7133164892+TRUB2chr9131079505-0.0194672120.98053277
ENST00000393161ENST00000372890EXOC4chr7133164892+TRUB2chr9131079505-0.0098158870.9901841
ENST00000393161ENST00000546104EXOC4chr7133164892+TRUB2chr9131079505-0.0128990660.98710096

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Fusion Genomic Features for EXOC4-TRUB2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for EXOC4-TRUB2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:133164892/chr9:131079505)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EXOC4

Q96A65

.
FUNCTION: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEXOC4chr7:133164892chr9:131079505ENST00000253861+91832_114472975.0Coiled coilOntology_term=ECO:0000255
HgeneEXOC4chr7:133164892chr9:131079505ENST00000393161+91032_114472474.0Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for EXOC4-TRUB2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>27922_27922_1_EXOC4-TRUB2_EXOC4_chr7_133164892_ENST00000253861_TRUB2_chr9_131079505_ENST00000372890_length(transcript)=2648nt_BP=1446nt
GGAGCCTAGCGGCTCTCCCCGCGTCCAAGATGGCGGCAGAAGCAGCTGGTGGGAAATACAGAAGCACAGTCAGCAAAAGCAAAGACCCCT
CGGGGCTGCTCATCTCTGTGATCAGGACTCTGTCTACTAGTGACGATGTCGAAGACAGGGAAAATGAAAAGGGTCGCCTTGAAGAAGCCT
ACGAGAAATGTGACCGTGACCTGGATGAATTGATTGTACAGCACTACACAGAATTGACGACAGCCATTCGCACATACCAGAGCATCACAG
AGCGCATCACTAACTCCCGAAATAAAATAAAGCAGGTAAAAGAGAACCTGCTTTCATGCAAGATGCTGCTGCACTGCAAACGGGATGAGC
TTCGGAAACTGTGGATTGAAGGAATTGAGCATAAGCATGTCCTGAACTTGTTGGATGAAATTGAGAATATCAAGCAAGTGCCTCAAAAGC
TGGAACAGTGCATGGCCAGCAAGCACTATCTCAGTGCCACTGACATGTTGGTGTCAGCAGTTGAGTCTTTGGAGGGCCCCCTGCTCCAGG
TGGAAGGACTGAGTGACCTTCGACTAGAGCTTCACAGCAAGAAGATGAACCTTCACTTGGTTCTCATAGATGAACTACACCGGCACCTGT
ACATCAAATCGACTAGCCGAGTTGTGCAGCGTAACAAGGAAAAAGGGAAAATCAGCTCCCTCGTGAAAGATGCTTCTGTTCCTCTGATTG
ATGTTACAAACCTCCCTACTCCTCGAAAATTCCTTGATACCTCTCACTATTCTACTGCTGGAAGCTCAAGTGTGAGGGAGATAAATCTGC
AGGACATCAAGGAAGATTTAGAATTGGATCCAGAGGAAAACAGCACCCTGTTTATGGGTATCCTCATTAAGGGCTTGGCGAAACTGAAGA
AGATCCCAGAAACAGTTAAGGCAATCATAGAGCGCTTGGAGCAGGAGTTGAAGCAAATTGTGAAGAGGTCTACAACCCAGGTGGCAGACA
GTGGCTATCAGCGGGGGGAGAACGTTACTGTGGAGAACCAACCAAGGTTGCTTCTAGAACTGCTGGAGTTACTGTTTGACAAGTTTAATG
CTGTAGCCGCTGCACACTCTGTGGTCCTGGGATACCTGCAGGACACTGTAGTGACTCCACTGACTCAGCAGGAAGATATCAAACTGTATG
ATATGGCAGATGTATGGGTGAAGATCCAAGATGTTCTACAGATGCTATTAACTGAGTACTTGGATATGAAAAATACTCGTACGGCCTCTG
AACCATCAGCTCAACTAAGCTATGCCAGCACTGGACGAGAGTTTGCAGCCTTTTTTGCCAAGAAGAAACCTCAAAGGCCAAAAAATTCTC
TTTTCAAGTTCGAATCGTCCTCCCATGCCATCAGTATGAGCGCCTATCTGCGAGAACAGAGAAGGGAGCTCTATAGTCGGAGTGGAGAAC
TGCAAGTATGTGGACCAGCATTCGCCCATCTCAAGGTTGGCGTGGGACATCGGTTGGATGCCCAGGCTTCTGGAGTACTTGTGCTCGGCG
TGGGACATGGATGCAGGCTCCTCACCGATATGTACAATGCTCATCTTACCAAGGATTACACAGTGCGTGGCCTCCTGGGCAAAGCTACAG
ATGACTTCCGTGAGGACGGGAGGCTGGTAGAGAAGACAACCTATGACCACGTGACCAGAGAGAAGCTGGACCGCATTCTGGCCGTTATCC
AAGGCTCCCATCAGAAGGCCCTGGTGATGTACTCCAACCTCGACCTGAAGACCCAGGAGGCCTATGAGATGGCCGTGAGAGGCCTGATCC
GGCCCATGAACAAGTCCCCGATGCTGATAACTGGCATCCGATGCCTCTACTTTGCACCTCCGGAATTCCTCTTAGAGGTGCAGTGCATGC
ATGAGACGCAGAAAGAGCTGCGGAAGTTGGTTCATGAAATCGGCCTGGAACTAAAGACCACTGCTGTCTGCACCCAAGTGCGGCGCACGC
GCGACGGCTTCTTCACGCTAGACAGTGCCCTCCTGAGGACCCAGTGGGACCTAACCAACATCCAGGATGCTATCCGGGCTGCTACCCCTC
AGGTAGCTGCAGAGCTGGAGAAGAGCTTGAGCCCGGGGCTGGACACCAAGCAGCTCCCCAGTCCGGGATGGTCCTGGGACTCCCAGGGCC
CGAGCTCTACCTTGGGGCTGGAGAGGGGTGCGGGGCAGTGAATGCCCAGGCAGCTCCTGGGGCAGTGGATGGATAAATAGAAGAACTGCT
ATGAGCTGGACCTGATAGCTGTGCAGAAAGTGAGAGCAGGGGCACCTTTTCTACGTAAGACACAAAACTCAAGCTGTAACAGAAAGGTCA
ATGGACTTGACCCAACTGAGAAGGAAAAACTTCTGTATGGAGGAAAAGACAGTAAACATGACAGACTGATAGAAAGTATTGGCAGACCAG
GCGTGGTGGCGGGCACTTGTAATCCCAGCTACTCCCAAGGCTGAGGCAGGAGAATTGCTTGAGCCCAGGAGTTTAAGGTTGTAGTGCGCT
AGACGGCGCCTGTGAATAGCCACTGCACTCTAGTCTGGGGAACATATGAGACCCCTGCCATCTCAAAAAAAAAAAAATTCTCAATAAACT

>27922_27922_1_EXOC4-TRUB2_EXOC4_chr7_133164892_ENST00000253861_TRUB2_chr9_131079505_ENST00000372890_length(amino acids)=723AA_BP=472
MAAEAAGGKYRSTVSKSKDPSGLLISVIRTLSTSDDVEDRENEKGRLEEAYEKCDRDLDELIVQHYTELTTAIRTYQSITERITNSRNKI
KQVKENLLSCKMLLHCKRDELRKLWIEGIEHKHVLNLLDEIENIKQVPQKLEQCMASKHYLSATDMLVSAVESLEGPLLQVEGLSDLRLE
LHSKKMNLHLVLIDELHRHLYIKSTSRVVQRNKEKGKISSLVKDASVPLIDVTNLPTPRKFLDTSHYSTAGSSSVREINLQDIKEDLELD
PEENSTLFMGILIKGLAKLKKIPETVKAIIERLEQELKQIVKRSTTQVADSGYQRGENVTVENQPRLLLELLELLFDKFNAVAAAHSVVL
GYLQDTVVTPLTQQEDIKLYDMADVWVKIQDVLQMLLTEYLDMKNTRTASEPSAQLSYASTGREFAAFFAKKKPQRPKNSLFKFESSSHA
ISMSAYLREQRRELYSRSGELQVCGPAFAHLKVGVGHRLDAQASGVLVLGVGHGCRLLTDMYNAHLTKDYTVRGLLGKATDDFREDGRLV
EKTTYDHVTREKLDRILAVIQGSHQKALVMYSNLDLKTQEAYEMAVRGLIRPMNKSPMLITGIRCLYFAPPEFLLEVQCMHETQKELRKL
VHEIGLELKTTAVCTQVRRTRDGFFTLDSALLRTQWDLTNIQDAIRAATPQVAAELEKSLSPGLDTKQLPSPGWSWDSQGPSSTLGLERG

--------------------------------------------------------------
>27922_27922_2_EXOC4-TRUB2_EXOC4_chr7_133164892_ENST00000253861_TRUB2_chr9_131079505_ENST00000546104_length(transcript)=2557nt_BP=1446nt
GGAGCCTAGCGGCTCTCCCCGCGTCCAAGATGGCGGCAGAAGCAGCTGGTGGGAAATACAGAAGCACAGTCAGCAAAAGCAAAGACCCCT
CGGGGCTGCTCATCTCTGTGATCAGGACTCTGTCTACTAGTGACGATGTCGAAGACAGGGAAAATGAAAAGGGTCGCCTTGAAGAAGCCT
ACGAGAAATGTGACCGTGACCTGGATGAATTGATTGTACAGCACTACACAGAATTGACGACAGCCATTCGCACATACCAGAGCATCACAG
AGCGCATCACTAACTCCCGAAATAAAATAAAGCAGGTAAAAGAGAACCTGCTTTCATGCAAGATGCTGCTGCACTGCAAACGGGATGAGC
TTCGGAAACTGTGGATTGAAGGAATTGAGCATAAGCATGTCCTGAACTTGTTGGATGAAATTGAGAATATCAAGCAAGTGCCTCAAAAGC
TGGAACAGTGCATGGCCAGCAAGCACTATCTCAGTGCCACTGACATGTTGGTGTCAGCAGTTGAGTCTTTGGAGGGCCCCCTGCTCCAGG
TGGAAGGACTGAGTGACCTTCGACTAGAGCTTCACAGCAAGAAGATGAACCTTCACTTGGTTCTCATAGATGAACTACACCGGCACCTGT
ACATCAAATCGACTAGCCGAGTTGTGCAGCGTAACAAGGAAAAAGGGAAAATCAGCTCCCTCGTGAAAGATGCTTCTGTTCCTCTGATTG
ATGTTACAAACCTCCCTACTCCTCGAAAATTCCTTGATACCTCTCACTATTCTACTGCTGGAAGCTCAAGTGTGAGGGAGATAAATCTGC
AGGACATCAAGGAAGATTTAGAATTGGATCCAGAGGAAAACAGCACCCTGTTTATGGGTATCCTCATTAAGGGCTTGGCGAAACTGAAGA
AGATCCCAGAAACAGTTAAGGCAATCATAGAGCGCTTGGAGCAGGAGTTGAAGCAAATTGTGAAGAGGTCTACAACCCAGGTGGCAGACA
GTGGCTATCAGCGGGGGGAGAACGTTACTGTGGAGAACCAACCAAGGTTGCTTCTAGAACTGCTGGAGTTACTGTTTGACAAGTTTAATG
CTGTAGCCGCTGCACACTCTGTGGTCCTGGGATACCTGCAGGACACTGTAGTGACTCCACTGACTCAGCAGGAAGATATCAAACTGTATG
ATATGGCAGATGTATGGGTGAAGATCCAAGATGTTCTACAGATGCTATTAACTGAGTACTTGGATATGAAAAATACTCGTACGGCCTCTG
AACCATCAGCTCAACTAAGCTATGCCAGCACTGGACGAGAGTTTGCAGCCTTTTTTGCCAAGAAGAAACCTCAAAGGCCAAAAAATTCTC
TTTTCAAGTTCGAATCGTCCTCCCATGCCATCAGTATGAGCGCCTATCTGCGAGAACAGAGAAGGGAGCTCTATAGTCGGAGTGGAGAAC
TGCAAGTATGTGGACCAGCATTCGCCCATCTCAAGGTTGGCGTGGGACATCGGTTGGATGCCCAGGCTTCTGGAGTACTTGTGCTCGGCG
TGGGACATGGATGCAGGCTCCTCACCGATATGTACAATGCTCATCTTACCAAGGATTACACAGTGCGTGGCCTCCTGGGCAAAGCTACAG
ATGACTTCCGTGAGGACGGGAGGCTGGTAGAGAAGACAACCTATGACCACGTGACCAGAGAGAAGCTGGACCGCATTCTGGCCGTTATCC
AAGGCTCCCATCAGAAGGCCCTGGTGATGTACTCCAACCTCGACCTGAAGACCCAGGAGGCCTATGAGATGGCCGTGAGAGGCCTGATCC
GGCCCATGAACAAGTCCCCGATGCTGATAACTGGCATCCGATGCCTCTACTTTGCACCTCCGGAATTCCTCTTAGAGGTGCAGTGCATGC
ATGAGACGCAGAAAGAGCTGCGGAAGTTGGTTCATGAAATCGGCCTGGAACTAAAGACCACTGCTGTCTGCACCCAAGTGCGGCGCACGC
GCGACGGCTTCTTCACGCTAGACAGTGCCCTCCTGAGGACCCAGTGGGACCTAACCAACATCCAGGATGCTATCCGGGCTGCTACCCCTC
AGGTAGCTGCAGAGCTGGAGAAGAGCTTGAGCCCGGGGCTGGACACCAAGCAGCTCCCCAGTCCGGGATGGTCCTGGGACTCCCAGGGCC
CGAGCTCTACCTTGGGGCTGGAGAGGGGTGCGGGGCAGTGAATGCCCAGGCAGCTCCTGGGGCAGTGGATGGATAAATAGAAGAACTGCT
ATGAGCTGGACCTGATAGCTGTGCAGAAAGTGAGAGCAGGGGCACCTTTTCTACGTAAGACACAAAACTCAAGCTGTAACAGAAAGGTCA
ATGGACTTGACCCAACTGAGAAGGAAAAACTTCTGTATGGAGGAAAAGACAGTAAACATGACAGACTGATAGAAAGTATTGGCAGACCAG
GCGTGGTGGCGGGCACTTGTAATCCCAGCTACTCCCAAGGCTGAGGCAGGAGAATTGCTTGAGCCCAGGAGTTTAAGGTTGTAGTGCGCT

>27922_27922_2_EXOC4-TRUB2_EXOC4_chr7_133164892_ENST00000253861_TRUB2_chr9_131079505_ENST00000546104_length(amino acids)=723AA_BP=472
MAAEAAGGKYRSTVSKSKDPSGLLISVIRTLSTSDDVEDRENEKGRLEEAYEKCDRDLDELIVQHYTELTTAIRTYQSITERITNSRNKI
KQVKENLLSCKMLLHCKRDELRKLWIEGIEHKHVLNLLDEIENIKQVPQKLEQCMASKHYLSATDMLVSAVESLEGPLLQVEGLSDLRLE
LHSKKMNLHLVLIDELHRHLYIKSTSRVVQRNKEKGKISSLVKDASVPLIDVTNLPTPRKFLDTSHYSTAGSSSVREINLQDIKEDLELD
PEENSTLFMGILIKGLAKLKKIPETVKAIIERLEQELKQIVKRSTTQVADSGYQRGENVTVENQPRLLLELLELLFDKFNAVAAAHSVVL
GYLQDTVVTPLTQQEDIKLYDMADVWVKIQDVLQMLLTEYLDMKNTRTASEPSAQLSYASTGREFAAFFAKKKPQRPKNSLFKFESSSHA
ISMSAYLREQRRELYSRSGELQVCGPAFAHLKVGVGHRLDAQASGVLVLGVGHGCRLLTDMYNAHLTKDYTVRGLLGKATDDFREDGRLV
EKTTYDHVTREKLDRILAVIQGSHQKALVMYSNLDLKTQEAYEMAVRGLIRPMNKSPMLITGIRCLYFAPPEFLLEVQCMHETQKELRKL
VHEIGLELKTTAVCTQVRRTRDGFFTLDSALLRTQWDLTNIQDAIRAATPQVAAELEKSLSPGLDTKQLPSPGWSWDSQGPSSTLGLERG

--------------------------------------------------------------
>27922_27922_3_EXOC4-TRUB2_EXOC4_chr7_133164892_ENST00000393161_TRUB2_chr9_131079505_ENST00000372890_length(transcript)=2648nt_BP=1446nt
GGAGCCTAGCGGCTCTCCCCGCGTCCAAGATGGCGGCAGAAGCAGCTGGTGGGAAATACAGAAGCACAGTCAGCAAAAGCAAAGACCCCT
CGGGGCTGCTCATCTCTGTGATCAGGACTCTGTCTACTAGTGACGATGTCGAAGACAGGGAAAATGAAAAGGGTCGCCTTGAAGAAGCCT
ACGAGAAATGTGACCGTGACCTGGATGAATTGATTGTACAGCACTACACAGAATTGACGACAGCCATTCGCACATACCAGAGCATCACAG
AGCGCATCACTAACTCCCGAAATAAAATAAAGCAGGTAAAAGAGAACCTGCTTTCATGCAAGATGCTGCTGCACTGCAAACGGGATGAGC
TTCGGAAACTGTGGATTGAAGGAATTGAGCATAAGCATGTCCTGAACTTGTTGGATGAAATTGAGAATATCAAGCAAGTGCCTCAAAAGC
TGGAACAGTGCATGGCCAGCAAGCACTATCTCAGTGCCACTGACATGTTGGTGTCAGCAGTTGAGTCTTTGGAGGGCCCCCTGCTCCAGG
TGGAAGGACTGAGTGACCTTCGACTAGAGCTTCACAGCAAGAAGATGAACCTTCACTTGGTTCTCATAGATGAACTACACCGGCACCTGT
ACATCAAATCGACTAGCCGAGTTGTGCAGCGTAACAAGGAAAAAGGGAAAATCAGCTCCCTCGTGAAAGATGCTTCTGTTCCTCTGATTG
ATGTTACAAACCTCCCTACTCCTCGAAAATTCCTTGATACCTCTCACTATTCTACTGCTGGAAGCTCAAGTGTGAGGGAGATAAATCTGC
AGGACATCAAGGAAGATTTAGAATTGGATCCAGAGGAAAACAGCACCCTGTTTATGGGTATCCTCATTAAGGGCTTGGCGAAACTGAAGA
AGATCCCAGAAACAGTTAAGGCAATCATAGAGCGCTTGGAGCAGGAGTTGAAGCAAATTGTGAAGAGGTCTACAACCCAGGTGGCAGACA
GTGGCTATCAGCGGGGGGAGAACGTTACTGTGGAGAACCAACCAAGGTTGCTTCTAGAACTGCTGGAGTTACTGTTTGACAAGTTTAATG
CTGTAGCCGCTGCACACTCTGTGGTCCTGGGATACCTGCAGGACACTGTAGTGACTCCACTGACTCAGCAGGAAGATATCAAACTGTATG
ATATGGCAGATGTATGGGTGAAGATCCAAGATGTTCTACAGATGCTATTAACTGAGTACTTGGATATGAAAAATACTCGTACGGCCTCTG
AACCATCAGCTCAACTAAGCTATGCCAGCACTGGACGAGAGTTTGCAGCCTTTTTTGCCAAGAAGAAACCTCAAAGGCCAAAAAATTCTC
TTTTCAAGTTCGAATCGTCCTCCCATGCCATCAGTATGAGCGCCTATCTGCGAGAACAGAGAAGGGAGCTCTATAGTCGGAGTGGAGAAC
TGCAAGTATGTGGACCAGCATTCGCCCATCTCAAGGTTGGCGTGGGACATCGGTTGGATGCCCAGGCTTCTGGAGTACTTGTGCTCGGCG
TGGGACATGGATGCAGGCTCCTCACCGATATGTACAATGCTCATCTTACCAAGGATTACACAGTGCGTGGCCTCCTGGGCAAAGCTACAG
ATGACTTCCGTGAGGACGGGAGGCTGGTAGAGAAGACAACCTATGACCACGTGACCAGAGAGAAGCTGGACCGCATTCTGGCCGTTATCC
AAGGCTCCCATCAGAAGGCCCTGGTGATGTACTCCAACCTCGACCTGAAGACCCAGGAGGCCTATGAGATGGCCGTGAGAGGCCTGATCC
GGCCCATGAACAAGTCCCCGATGCTGATAACTGGCATCCGATGCCTCTACTTTGCACCTCCGGAATTCCTCTTAGAGGTGCAGTGCATGC
ATGAGACGCAGAAAGAGCTGCGGAAGTTGGTTCATGAAATCGGCCTGGAACTAAAGACCACTGCTGTCTGCACCCAAGTGCGGCGCACGC
GCGACGGCTTCTTCACGCTAGACAGTGCCCTCCTGAGGACCCAGTGGGACCTAACCAACATCCAGGATGCTATCCGGGCTGCTACCCCTC
AGGTAGCTGCAGAGCTGGAGAAGAGCTTGAGCCCGGGGCTGGACACCAAGCAGCTCCCCAGTCCGGGATGGTCCTGGGACTCCCAGGGCC
CGAGCTCTACCTTGGGGCTGGAGAGGGGTGCGGGGCAGTGAATGCCCAGGCAGCTCCTGGGGCAGTGGATGGATAAATAGAAGAACTGCT
ATGAGCTGGACCTGATAGCTGTGCAGAAAGTGAGAGCAGGGGCACCTTTTCTACGTAAGACACAAAACTCAAGCTGTAACAGAAAGGTCA
ATGGACTTGACCCAACTGAGAAGGAAAAACTTCTGTATGGAGGAAAAGACAGTAAACATGACAGACTGATAGAAAGTATTGGCAGACCAG
GCGTGGTGGCGGGCACTTGTAATCCCAGCTACTCCCAAGGCTGAGGCAGGAGAATTGCTTGAGCCCAGGAGTTTAAGGTTGTAGTGCGCT
AGACGGCGCCTGTGAATAGCCACTGCACTCTAGTCTGGGGAACATATGAGACCCCTGCCATCTCAAAAAAAAAAAAATTCTCAATAAACT

>27922_27922_3_EXOC4-TRUB2_EXOC4_chr7_133164892_ENST00000393161_TRUB2_chr9_131079505_ENST00000372890_length(amino acids)=723AA_BP=472
MAAEAAGGKYRSTVSKSKDPSGLLISVIRTLSTSDDVEDRENEKGRLEEAYEKCDRDLDELIVQHYTELTTAIRTYQSITERITNSRNKI
KQVKENLLSCKMLLHCKRDELRKLWIEGIEHKHVLNLLDEIENIKQVPQKLEQCMASKHYLSATDMLVSAVESLEGPLLQVEGLSDLRLE
LHSKKMNLHLVLIDELHRHLYIKSTSRVVQRNKEKGKISSLVKDASVPLIDVTNLPTPRKFLDTSHYSTAGSSSVREINLQDIKEDLELD
PEENSTLFMGILIKGLAKLKKIPETVKAIIERLEQELKQIVKRSTTQVADSGYQRGENVTVENQPRLLLELLELLFDKFNAVAAAHSVVL
GYLQDTVVTPLTQQEDIKLYDMADVWVKIQDVLQMLLTEYLDMKNTRTASEPSAQLSYASTGREFAAFFAKKKPQRPKNSLFKFESSSHA
ISMSAYLREQRRELYSRSGELQVCGPAFAHLKVGVGHRLDAQASGVLVLGVGHGCRLLTDMYNAHLTKDYTVRGLLGKATDDFREDGRLV
EKTTYDHVTREKLDRILAVIQGSHQKALVMYSNLDLKTQEAYEMAVRGLIRPMNKSPMLITGIRCLYFAPPEFLLEVQCMHETQKELRKL
VHEIGLELKTTAVCTQVRRTRDGFFTLDSALLRTQWDLTNIQDAIRAATPQVAAELEKSLSPGLDTKQLPSPGWSWDSQGPSSTLGLERG

--------------------------------------------------------------
>27922_27922_4_EXOC4-TRUB2_EXOC4_chr7_133164892_ENST00000393161_TRUB2_chr9_131079505_ENST00000546104_length(transcript)=2557nt_BP=1446nt
GGAGCCTAGCGGCTCTCCCCGCGTCCAAGATGGCGGCAGAAGCAGCTGGTGGGAAATACAGAAGCACAGTCAGCAAAAGCAAAGACCCCT
CGGGGCTGCTCATCTCTGTGATCAGGACTCTGTCTACTAGTGACGATGTCGAAGACAGGGAAAATGAAAAGGGTCGCCTTGAAGAAGCCT
ACGAGAAATGTGACCGTGACCTGGATGAATTGATTGTACAGCACTACACAGAATTGACGACAGCCATTCGCACATACCAGAGCATCACAG
AGCGCATCACTAACTCCCGAAATAAAATAAAGCAGGTAAAAGAGAACCTGCTTTCATGCAAGATGCTGCTGCACTGCAAACGGGATGAGC
TTCGGAAACTGTGGATTGAAGGAATTGAGCATAAGCATGTCCTGAACTTGTTGGATGAAATTGAGAATATCAAGCAAGTGCCTCAAAAGC
TGGAACAGTGCATGGCCAGCAAGCACTATCTCAGTGCCACTGACATGTTGGTGTCAGCAGTTGAGTCTTTGGAGGGCCCCCTGCTCCAGG
TGGAAGGACTGAGTGACCTTCGACTAGAGCTTCACAGCAAGAAGATGAACCTTCACTTGGTTCTCATAGATGAACTACACCGGCACCTGT
ACATCAAATCGACTAGCCGAGTTGTGCAGCGTAACAAGGAAAAAGGGAAAATCAGCTCCCTCGTGAAAGATGCTTCTGTTCCTCTGATTG
ATGTTACAAACCTCCCTACTCCTCGAAAATTCCTTGATACCTCTCACTATTCTACTGCTGGAAGCTCAAGTGTGAGGGAGATAAATCTGC
AGGACATCAAGGAAGATTTAGAATTGGATCCAGAGGAAAACAGCACCCTGTTTATGGGTATCCTCATTAAGGGCTTGGCGAAACTGAAGA
AGATCCCAGAAACAGTTAAGGCAATCATAGAGCGCTTGGAGCAGGAGTTGAAGCAAATTGTGAAGAGGTCTACAACCCAGGTGGCAGACA
GTGGCTATCAGCGGGGGGAGAACGTTACTGTGGAGAACCAACCAAGGTTGCTTCTAGAACTGCTGGAGTTACTGTTTGACAAGTTTAATG
CTGTAGCCGCTGCACACTCTGTGGTCCTGGGATACCTGCAGGACACTGTAGTGACTCCACTGACTCAGCAGGAAGATATCAAACTGTATG
ATATGGCAGATGTATGGGTGAAGATCCAAGATGTTCTACAGATGCTATTAACTGAGTACTTGGATATGAAAAATACTCGTACGGCCTCTG
AACCATCAGCTCAACTAAGCTATGCCAGCACTGGACGAGAGTTTGCAGCCTTTTTTGCCAAGAAGAAACCTCAAAGGCCAAAAAATTCTC
TTTTCAAGTTCGAATCGTCCTCCCATGCCATCAGTATGAGCGCCTATCTGCGAGAACAGAGAAGGGAGCTCTATAGTCGGAGTGGAGAAC
TGCAAGTATGTGGACCAGCATTCGCCCATCTCAAGGTTGGCGTGGGACATCGGTTGGATGCCCAGGCTTCTGGAGTACTTGTGCTCGGCG
TGGGACATGGATGCAGGCTCCTCACCGATATGTACAATGCTCATCTTACCAAGGATTACACAGTGCGTGGCCTCCTGGGCAAAGCTACAG
ATGACTTCCGTGAGGACGGGAGGCTGGTAGAGAAGACAACCTATGACCACGTGACCAGAGAGAAGCTGGACCGCATTCTGGCCGTTATCC
AAGGCTCCCATCAGAAGGCCCTGGTGATGTACTCCAACCTCGACCTGAAGACCCAGGAGGCCTATGAGATGGCCGTGAGAGGCCTGATCC
GGCCCATGAACAAGTCCCCGATGCTGATAACTGGCATCCGATGCCTCTACTTTGCACCTCCGGAATTCCTCTTAGAGGTGCAGTGCATGC
ATGAGACGCAGAAAGAGCTGCGGAAGTTGGTTCATGAAATCGGCCTGGAACTAAAGACCACTGCTGTCTGCACCCAAGTGCGGCGCACGC
GCGACGGCTTCTTCACGCTAGACAGTGCCCTCCTGAGGACCCAGTGGGACCTAACCAACATCCAGGATGCTATCCGGGCTGCTACCCCTC
AGGTAGCTGCAGAGCTGGAGAAGAGCTTGAGCCCGGGGCTGGACACCAAGCAGCTCCCCAGTCCGGGATGGTCCTGGGACTCCCAGGGCC
CGAGCTCTACCTTGGGGCTGGAGAGGGGTGCGGGGCAGTGAATGCCCAGGCAGCTCCTGGGGCAGTGGATGGATAAATAGAAGAACTGCT
ATGAGCTGGACCTGATAGCTGTGCAGAAAGTGAGAGCAGGGGCACCTTTTCTACGTAAGACACAAAACTCAAGCTGTAACAGAAAGGTCA
ATGGACTTGACCCAACTGAGAAGGAAAAACTTCTGTATGGAGGAAAAGACAGTAAACATGACAGACTGATAGAAAGTATTGGCAGACCAG
GCGTGGTGGCGGGCACTTGTAATCCCAGCTACTCCCAAGGCTGAGGCAGGAGAATTGCTTGAGCCCAGGAGTTTAAGGTTGTAGTGCGCT

>27922_27922_4_EXOC4-TRUB2_EXOC4_chr7_133164892_ENST00000393161_TRUB2_chr9_131079505_ENST00000546104_length(amino acids)=723AA_BP=472
MAAEAAGGKYRSTVSKSKDPSGLLISVIRTLSTSDDVEDRENEKGRLEEAYEKCDRDLDELIVQHYTELTTAIRTYQSITERITNSRNKI
KQVKENLLSCKMLLHCKRDELRKLWIEGIEHKHVLNLLDEIENIKQVPQKLEQCMASKHYLSATDMLVSAVESLEGPLLQVEGLSDLRLE
LHSKKMNLHLVLIDELHRHLYIKSTSRVVQRNKEKGKISSLVKDASVPLIDVTNLPTPRKFLDTSHYSTAGSSSVREINLQDIKEDLELD
PEENSTLFMGILIKGLAKLKKIPETVKAIIERLEQELKQIVKRSTTQVADSGYQRGENVTVENQPRLLLELLELLFDKFNAVAAAHSVVL
GYLQDTVVTPLTQQEDIKLYDMADVWVKIQDVLQMLLTEYLDMKNTRTASEPSAQLSYASTGREFAAFFAKKKPQRPKNSLFKFESSSHA
ISMSAYLREQRRELYSRSGELQVCGPAFAHLKVGVGHRLDAQASGVLVLGVGHGCRLLTDMYNAHLTKDYTVRGLLGKATDDFREDGRLV
EKTTYDHVTREKLDRILAVIQGSHQKALVMYSNLDLKTQEAYEMAVRGLIRPMNKSPMLITGIRCLYFAPPEFLLEVQCMHETQKELRKL
VHEIGLELKTTAVCTQVRRTRDGFFTLDSALLRTQWDLTNIQDAIRAATPQVAAELEKSLSPGLDTKQLPSPGWSWDSQGPSSTLGLERG

--------------------------------------------------------------
>27922_27922_5_EXOC4-TRUB2_EXOC4_chr7_133164892_ENST00000539845_TRUB2_chr9_131079505_ENST00000372890_length(transcript)=2655nt_BP=1453nt
GGGGTTAGCTATAGAGAGAGGAGCCCCGCCTCAGTCTTTTCTTTAGGGGCAGCACCTTCTATTACAGTCTCGGGACCCCAAAGCACGCTA
TTTGGGTTTGGTAGAGAAAACCAGGTGTAAAGGACTCTGTCTACTAGTGACGATGTCGAAGACAGGGAAAATGAAAAGGGTCGCCTTGAA
GAAGCCTACGAGAAATGTGACCGTGACCTGGATGAATTGATTGTACAGCACTACACAGAATTGACGACAGCCATTCGCACATACCAGAGC
ATCACAGAGCGCATCACTAACTCCCGAAATAAAATAAAGCAGGTAAAAGAGAACCTGCTTTCATGCAAGATGCTGCTGCACTGCAAACGG
GATGAGCTTCGGAAACTGTGGATTGAAGGAATTGAGCATAAGCATGTCCTGAACTTGTTGGATGAAATTGAGAATATCAAGCAAGTGCCT
CAAAAGCTGGAACAGTGCATGGCCAGCAAGCACTATCTCAGTGCCACTGACATGTTGGTGTCAGCAGTTGAGTCTTTGGAGGGCCCCCTG
CTCCAGGTGGAAGGACTGAGTGACCTTCGACTAGAGCTTCACAGCAAGAAGATGAACCTTCACTTGGTTCTCATAGATGAACTACACCGG
CACCTGTACATCAAATCGACTAGCCGAGTTGTGCAGCGTAACAAGGAAAAAGGGAAAATCAGCTCCCTCGTGAAAGATGCTTCTGTTCCT
CTGATTGATGTTACAAACCTCCCTACTCCTCGAAAATTCCTTGATACCTCTCACTATTCTACTGCTGGAAGCTCAAGTGTGAGGGAGATA
AATCTGCAGGACATCAAGGAAGATTTAGAATTGGATCCAGAGGAAAACAGCACCCTGTTTATGGGTATCCTCATTAAGGGCTTGGCGAAA
CTGAAGAAGATCCCAGAAACAGTTAAGGCAATCATAGAGCGCTTGGAGCAGGAGTTGAAGCAAATTGTGAAGAGGTCTACAACCCAGGTG
GCAGACAGTGGCTATCAGCGGGGGGAGAACGTTACTGTGGAGAACCAACCAAGGTTGCTTCTAGAACTGCTGGAGTTACTGTTTGACAAG
TTTAATGCTGTAGCCGCTGCACACTCTGTGGTCCTGGGATACCTGCAGGACACTGTAGTGACTCCACTGACTCAGCAGGAAGATATCAAA
CTGTATGATATGGCAGATGTATGGGTGAAGATCCAAGATGTTCTACAGATGCTATTAACTGAGTACTTGGATATGAAAAATACTCGTACG
GCCTCTGAACCATCAGCTCAACTAAGCTATGCCAGCACTGGACGAGAGTTTGCAGCCTTTTTTGCCAAGAAGAAACCTCAAAGGCCAAAA
AATTCTCTTTTCAAGTTCGAATCGTCCTCCCATGCCATCAGTATGAGCGCCTATCTGCGAGAACAGAGAAGGGAGCTCTATAGTCGGAGT
GGAGAACTGCAAGTATGTGGACCAGCATTCGCCCATCTCAAGGTTGGCGTGGGACATCGGTTGGATGCCCAGGCTTCTGGAGTACTTGTG
CTCGGCGTGGGACATGGATGCAGGCTCCTCACCGATATGTACAATGCTCATCTTACCAAGGATTACACAGTGCGTGGCCTCCTGGGCAAA
GCTACAGATGACTTCCGTGAGGACGGGAGGCTGGTAGAGAAGACAACCTATGACCACGTGACCAGAGAGAAGCTGGACCGCATTCTGGCC
GTTATCCAAGGCTCCCATCAGAAGGCCCTGGTGATGTACTCCAACCTCGACCTGAAGACCCAGGAGGCCTATGAGATGGCCGTGAGAGGC
CTGATCCGGCCCATGAACAAGTCCCCGATGCTGATAACTGGCATCCGATGCCTCTACTTTGCACCTCCGGAATTCCTCTTAGAGGTGCAG
TGCATGCATGAGACGCAGAAAGAGCTGCGGAAGTTGGTTCATGAAATCGGCCTGGAACTAAAGACCACTGCTGTCTGCACCCAAGTGCGG
CGCACGCGCGACGGCTTCTTCACGCTAGACAGTGCCCTCCTGAGGACCCAGTGGGACCTAACCAACATCCAGGATGCTATCCGGGCTGCT
ACCCCTCAGGTAGCTGCAGAGCTGGAGAAGAGCTTGAGCCCGGGGCTGGACACCAAGCAGCTCCCCAGTCCGGGATGGTCCTGGGACTCC
CAGGGCCCGAGCTCTACCTTGGGGCTGGAGAGGGGTGCGGGGCAGTGAATGCCCAGGCAGCTCCTGGGGCAGTGGATGGATAAATAGAAG
AACTGCTATGAGCTGGACCTGATAGCTGTGCAGAAAGTGAGAGCAGGGGCACCTTTTCTACGTAAGACACAAAACTCAAGCTGTAACAGA
AAGGTCAATGGACTTGACCCAACTGAGAAGGAAAAACTTCTGTATGGAGGAAAAGACAGTAAACATGACAGACTGATAGAAAGTATTGGC
AGACCAGGCGTGGTGGCGGGCACTTGTAATCCCAGCTACTCCCAAGGCTGAGGCAGGAGAATTGCTTGAGCCCAGGAGTTTAAGGTTGTA
GTGCGCTAGACGGCGCCTGTGAATAGCCACTGCACTCTAGTCTGGGGAACATATGAGACCCCTGCCATCTCAAAAAAAAAAAAATTCTCA

>27922_27922_5_EXOC4-TRUB2_EXOC4_chr7_133164892_ENST00000539845_TRUB2_chr9_131079505_ENST00000372890_length(amino acids)=693AA_BP=442
MSTSDDVEDRENEKGRLEEAYEKCDRDLDELIVQHYTELTTAIRTYQSITERITNSRNKIKQVKENLLSCKMLLHCKRDELRKLWIEGIE
HKHVLNLLDEIENIKQVPQKLEQCMASKHYLSATDMLVSAVESLEGPLLQVEGLSDLRLELHSKKMNLHLVLIDELHRHLYIKSTSRVVQ
RNKEKGKISSLVKDASVPLIDVTNLPTPRKFLDTSHYSTAGSSSVREINLQDIKEDLELDPEENSTLFMGILIKGLAKLKKIPETVKAII
ERLEQELKQIVKRSTTQVADSGYQRGENVTVENQPRLLLELLELLFDKFNAVAAAHSVVLGYLQDTVVTPLTQQEDIKLYDMADVWVKIQ
DVLQMLLTEYLDMKNTRTASEPSAQLSYASTGREFAAFFAKKKPQRPKNSLFKFESSSHAISMSAYLREQRRELYSRSGELQVCGPAFAH
LKVGVGHRLDAQASGVLVLGVGHGCRLLTDMYNAHLTKDYTVRGLLGKATDDFREDGRLVEKTTYDHVTREKLDRILAVIQGSHQKALVM
YSNLDLKTQEAYEMAVRGLIRPMNKSPMLITGIRCLYFAPPEFLLEVQCMHETQKELRKLVHEIGLELKTTAVCTQVRRTRDGFFTLDSA

--------------------------------------------------------------
>27922_27922_6_EXOC4-TRUB2_EXOC4_chr7_133164892_ENST00000539845_TRUB2_chr9_131079505_ENST00000546104_length(transcript)=2564nt_BP=1453nt
GGGGTTAGCTATAGAGAGAGGAGCCCCGCCTCAGTCTTTTCTTTAGGGGCAGCACCTTCTATTACAGTCTCGGGACCCCAAAGCACGCTA
TTTGGGTTTGGTAGAGAAAACCAGGTGTAAAGGACTCTGTCTACTAGTGACGATGTCGAAGACAGGGAAAATGAAAAGGGTCGCCTTGAA
GAAGCCTACGAGAAATGTGACCGTGACCTGGATGAATTGATTGTACAGCACTACACAGAATTGACGACAGCCATTCGCACATACCAGAGC
ATCACAGAGCGCATCACTAACTCCCGAAATAAAATAAAGCAGGTAAAAGAGAACCTGCTTTCATGCAAGATGCTGCTGCACTGCAAACGG
GATGAGCTTCGGAAACTGTGGATTGAAGGAATTGAGCATAAGCATGTCCTGAACTTGTTGGATGAAATTGAGAATATCAAGCAAGTGCCT
CAAAAGCTGGAACAGTGCATGGCCAGCAAGCACTATCTCAGTGCCACTGACATGTTGGTGTCAGCAGTTGAGTCTTTGGAGGGCCCCCTG
CTCCAGGTGGAAGGACTGAGTGACCTTCGACTAGAGCTTCACAGCAAGAAGATGAACCTTCACTTGGTTCTCATAGATGAACTACACCGG
CACCTGTACATCAAATCGACTAGCCGAGTTGTGCAGCGTAACAAGGAAAAAGGGAAAATCAGCTCCCTCGTGAAAGATGCTTCTGTTCCT
CTGATTGATGTTACAAACCTCCCTACTCCTCGAAAATTCCTTGATACCTCTCACTATTCTACTGCTGGAAGCTCAAGTGTGAGGGAGATA
AATCTGCAGGACATCAAGGAAGATTTAGAATTGGATCCAGAGGAAAACAGCACCCTGTTTATGGGTATCCTCATTAAGGGCTTGGCGAAA
CTGAAGAAGATCCCAGAAACAGTTAAGGCAATCATAGAGCGCTTGGAGCAGGAGTTGAAGCAAATTGTGAAGAGGTCTACAACCCAGGTG
GCAGACAGTGGCTATCAGCGGGGGGAGAACGTTACTGTGGAGAACCAACCAAGGTTGCTTCTAGAACTGCTGGAGTTACTGTTTGACAAG
TTTAATGCTGTAGCCGCTGCACACTCTGTGGTCCTGGGATACCTGCAGGACACTGTAGTGACTCCACTGACTCAGCAGGAAGATATCAAA
CTGTATGATATGGCAGATGTATGGGTGAAGATCCAAGATGTTCTACAGATGCTATTAACTGAGTACTTGGATATGAAAAATACTCGTACG
GCCTCTGAACCATCAGCTCAACTAAGCTATGCCAGCACTGGACGAGAGTTTGCAGCCTTTTTTGCCAAGAAGAAACCTCAAAGGCCAAAA
AATTCTCTTTTCAAGTTCGAATCGTCCTCCCATGCCATCAGTATGAGCGCCTATCTGCGAGAACAGAGAAGGGAGCTCTATAGTCGGAGT
GGAGAACTGCAAGTATGTGGACCAGCATTCGCCCATCTCAAGGTTGGCGTGGGACATCGGTTGGATGCCCAGGCTTCTGGAGTACTTGTG
CTCGGCGTGGGACATGGATGCAGGCTCCTCACCGATATGTACAATGCTCATCTTACCAAGGATTACACAGTGCGTGGCCTCCTGGGCAAA
GCTACAGATGACTTCCGTGAGGACGGGAGGCTGGTAGAGAAGACAACCTATGACCACGTGACCAGAGAGAAGCTGGACCGCATTCTGGCC
GTTATCCAAGGCTCCCATCAGAAGGCCCTGGTGATGTACTCCAACCTCGACCTGAAGACCCAGGAGGCCTATGAGATGGCCGTGAGAGGC
CTGATCCGGCCCATGAACAAGTCCCCGATGCTGATAACTGGCATCCGATGCCTCTACTTTGCACCTCCGGAATTCCTCTTAGAGGTGCAG
TGCATGCATGAGACGCAGAAAGAGCTGCGGAAGTTGGTTCATGAAATCGGCCTGGAACTAAAGACCACTGCTGTCTGCACCCAAGTGCGG
CGCACGCGCGACGGCTTCTTCACGCTAGACAGTGCCCTCCTGAGGACCCAGTGGGACCTAACCAACATCCAGGATGCTATCCGGGCTGCT
ACCCCTCAGGTAGCTGCAGAGCTGGAGAAGAGCTTGAGCCCGGGGCTGGACACCAAGCAGCTCCCCAGTCCGGGATGGTCCTGGGACTCC
CAGGGCCCGAGCTCTACCTTGGGGCTGGAGAGGGGTGCGGGGCAGTGAATGCCCAGGCAGCTCCTGGGGCAGTGGATGGATAAATAGAAG
AACTGCTATGAGCTGGACCTGATAGCTGTGCAGAAAGTGAGAGCAGGGGCACCTTTTCTACGTAAGACACAAAACTCAAGCTGTAACAGA
AAGGTCAATGGACTTGACCCAACTGAGAAGGAAAAACTTCTGTATGGAGGAAAAGACAGTAAACATGACAGACTGATAGAAAGTATTGGC
AGACCAGGCGTGGTGGCGGGCACTTGTAATCCCAGCTACTCCCAAGGCTGAGGCAGGAGAATTGCTTGAGCCCAGGAGTTTAAGGTTGTA

>27922_27922_6_EXOC4-TRUB2_EXOC4_chr7_133164892_ENST00000539845_TRUB2_chr9_131079505_ENST00000546104_length(amino acids)=693AA_BP=442
MSTSDDVEDRENEKGRLEEAYEKCDRDLDELIVQHYTELTTAIRTYQSITERITNSRNKIKQVKENLLSCKMLLHCKRDELRKLWIEGIE
HKHVLNLLDEIENIKQVPQKLEQCMASKHYLSATDMLVSAVESLEGPLLQVEGLSDLRLELHSKKMNLHLVLIDELHRHLYIKSTSRVVQ
RNKEKGKISSLVKDASVPLIDVTNLPTPRKFLDTSHYSTAGSSSVREINLQDIKEDLELDPEENSTLFMGILIKGLAKLKKIPETVKAII
ERLEQELKQIVKRSTTQVADSGYQRGENVTVENQPRLLLELLELLFDKFNAVAAAHSVVLGYLQDTVVTPLTQQEDIKLYDMADVWVKIQ
DVLQMLLTEYLDMKNTRTASEPSAQLSYASTGREFAAFFAKKKPQRPKNSLFKFESSSHAISMSAYLREQRRELYSRSGELQVCGPAFAH
LKVGVGHRLDAQASGVLVLGVGHGCRLLTDMYNAHLTKDYTVRGLLGKATDDFREDGRLVEKTTYDHVTREKLDRILAVIQGSHQKALVM
YSNLDLKTQEAYEMAVRGLIRPMNKSPMLITGIRCLYFAPPEFLLEVQCMHETQKELRKLVHEIGLELKTTAVCTQVRRTRDGFFTLDSA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for EXOC4-TRUB2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for EXOC4-TRUB2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for EXOC4-TRUB2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource