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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:EXOC7-ALG3 (FusionGDB2 ID:27952)

Fusion Gene Summary for EXOC7-ALG3

check button Fusion gene summary
Fusion gene informationFusion gene name: EXOC7-ALG3
Fusion gene ID: 27952
HgeneTgene
Gene symbol

EXOC7

ALG3

Gene ID

23265

10195

Gene nameexocyst complex component 7ALG3 alpha-1,3- mannosyltransferase
Synonyms2-5-3p|BLOM4|EX070|EXO70|EXOC1|Exo70p|YJL085WCDG1D|CDGS4|CDGS6|D16Ertd36e|NOT56L|Not56|not
Cytomap

17q25.1

3q27.1

Type of geneprotein-codingprotein-coding
Descriptionexocyst complex component 7exocyst complex component Exo70dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferaseNot56-like proteinasparagine-linked glycosylation 3 homolog (S. cerevisiae, alpha-1,3-mannosyltransferase)asparagine-linked glycosylation 3 homolog (yeast, alpha-1,3-mannosyltransferase)asp
Modification date2020031320200322
UniProtAcc

Q9UPT5

Q92685

Ensembl transtripts involved in fusion geneENST00000332065, ENST00000335146, 
ENST00000405575, ENST00000406660, 
ENST00000411744, ENST00000467929, 
ENST00000589210, ENST00000591724, 
ENST00000607838, 		ENST00000397676, 
ENST00000418734, ENST00000445626, 
ENST00000455059, ENST00000463495, 
Fusion gene scores* DoF score13 X 14 X 5=9107 X 5 X 5=175
# samples 136
** MAII scorelog2(13/910*10)=-2.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/175*10)=-1.54432051622381
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EXOC7 [Title/Abstract] AND ALG3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointEXOC7(74077970)-ALG3(183960723), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across EXOC7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ALG3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABF916293EXOC7chr17

74077970

-ALG3chr3

183960723

+
ChiTaRS5.0N/ABF916298EXOC7chr17

74077970

-ALG3chr3

183960723

+


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Fusion Gene ORF analysis for EXOC7-ALG3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000332065ENST00000397676EXOC7chr17

74077970

-ALG3chr3

183960723

+
intron-3CDSENST00000332065ENST00000418734EXOC7chr17

74077970

-ALG3chr3

183960723

+
intron-3CDSENST00000332065ENST00000445626EXOC7chr17

74077970

-ALG3chr3

183960723

+
intron-3CDSENST00000332065ENST00000455059EXOC7chr17

74077970

-ALG3chr3

183960723

+
intron-3CDSENST00000335146ENST00000397676EXOC7chr17

74077970

-ALG3chr3

183960723

+
intron-3CDSENST00000335146ENST00000418734EXOC7chr17

74077970

-ALG3chr3

183960723

+
intron-3CDSENST00000335146ENST00000445626EXOC7chr17

74077970

-ALG3chr3

183960723

+
intron-3CDSENST00000335146ENST00000455059EXOC7chr17

74077970

-ALG3chr3

183960723

+
intron-3CDSENST00000405575ENST00000397676EXOC7chr17

74077970

-ALG3chr3

183960723

+
intron-3CDSENST00000405575ENST00000418734EXOC7chr17

74077970

-ALG3chr3

183960723

+
intron-3CDSENST00000405575ENST00000445626EXOC7chr17

74077970

-ALG3chr3

183960723

+
intron-3CDSENST00000405575ENST00000455059EXOC7chr17

74077970

-ALG3chr3

183960723

+
intron-3CDSENST00000406660ENST00000397676EXOC7chr17

74077970

-ALG3chr3

183960723

+
intron-3CDSENST00000406660ENST00000418734EXOC7chr17

74077970

-ALG3chr3

183960723

+
intron-3CDSENST00000406660ENST00000445626EXOC7chr17

74077970

-ALG3chr3

183960723

+
intron-3CDSENST00000406660ENST00000455059EXOC7chr17

74077970

-ALG3chr3

183960723

+
intron-3CDSENST00000411744ENST00000397676EXOC7chr17

74077970

-ALG3chr3

183960723

+
intron-3CDSENST00000411744ENST00000418734EXOC7chr17

74077970

-ALG3chr3

183960723

+
intron-3CDSENST00000411744ENST00000445626EXOC7chr17

74077970

-ALG3chr3

183960723

+
intron-3CDSENST00000411744ENST00000455059EXOC7chr17

74077970

-ALG3chr3

183960723

+
intron-3CDSENST00000467929ENST00000397676EXOC7chr17

74077970

-ALG3chr3

183960723

+
intron-3CDSENST00000467929ENST00000418734EXOC7chr17

74077970

-ALG3chr3

183960723

+
intron-3CDSENST00000467929ENST00000445626EXOC7chr17

74077970

-ALG3chr3

183960723

+
intron-3CDSENST00000467929ENST00000455059EXOC7chr17

74077970

-ALG3chr3

183960723

+
intron-3CDSENST00000589210ENST00000397676EXOC7chr17

74077970

-ALG3chr3

183960723

+
intron-3CDSENST00000589210ENST00000418734EXOC7chr17

74077970

-ALG3chr3

183960723

+
intron-3CDSENST00000589210ENST00000445626EXOC7chr17

74077970

-ALG3chr3

183960723

+
intron-3CDSENST00000589210ENST00000455059EXOC7chr17

74077970

-ALG3chr3

183960723

+
intron-3CDSENST00000591724ENST00000397676EXOC7chr17

74077970

-ALG3chr3

183960723

+
intron-3CDSENST00000591724ENST00000418734EXOC7chr17

74077970

-ALG3chr3

183960723

+
intron-3CDSENST00000591724ENST00000445626EXOC7chr17

74077970

-ALG3chr3

183960723

+
intron-3CDSENST00000591724ENST00000455059EXOC7chr17

74077970

-ALG3chr3

183960723

+
intron-3CDSENST00000607838ENST00000397676EXOC7chr17

74077970

-ALG3chr3

183960723

+
intron-3CDSENST00000607838ENST00000418734EXOC7chr17

74077970

-ALG3chr3

183960723

+
intron-3CDSENST00000607838ENST00000445626EXOC7chr17

74077970

-ALG3chr3

183960723

+
intron-3CDSENST00000607838ENST00000455059EXOC7chr17

74077970

-ALG3chr3

183960723

+
intron-intronENST00000332065ENST00000463495EXOC7chr17

74077970

-ALG3chr3

183960723

+
intron-intronENST00000335146ENST00000463495EXOC7chr17

74077970

-ALG3chr3

183960723

+
intron-intronENST00000405575ENST00000463495EXOC7chr17

74077970

-ALG3chr3

183960723

+
intron-intronENST00000406660ENST00000463495EXOC7chr17

74077970

-ALG3chr3

183960723

+
intron-intronENST00000411744ENST00000463495EXOC7chr17

74077970

-ALG3chr3

183960723

+
intron-intronENST00000467929ENST00000463495EXOC7chr17

74077970

-ALG3chr3

183960723

+
intron-intronENST00000589210ENST00000463495EXOC7chr17

74077970

-ALG3chr3

183960723

+
intron-intronENST00000591724ENST00000463495EXOC7chr17

74077970

-ALG3chr3

183960723

+
intron-intronENST00000607838ENST00000463495EXOC7chr17

74077970

-ALG3chr3

183960723

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for EXOC7-ALG3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for EXOC7-ALG3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:74077970/:183960723)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EXOC7

Q9UPT5

ALG3

Q92685

FUNCTION: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. In adipocytes, plays a crucial role in targeting SLC2A4 vesicle to the plasma membrane in response to insulin, perhaps directing the vesicle to the precise site of fusion (By similarity). {ECO:0000250}.FUNCTION: Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man5GlcNAc2-PP-Dol. {ECO:0000269|PubMed:10581255}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for EXOC7-ALG3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for EXOC7-ALG3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for EXOC7-ALG3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for EXOC7-ALG3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource