Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:EXOSC4-NEIL2 (FusionGDB2 ID:27981)

Fusion Gene Summary for EXOSC4-NEIL2

Fusion gene summary

Fusion gene information	Fusion gene name: EXOSC4-NEIL2
	Fusion gene ID: 27981
		Hgene	Tgene
	Gene symbol	EXOSC4	NEIL2
	Gene ID	54512	252969
	Gene name	exosome component 4	nei like DNA glycosylase 2
	Synonyms	RRP41\|RRP41A\|Rrp41p\|SKI6\|Ski6p\|hRrp41p\|p12A	NEH2\|NEI2
	Cytomap	8q24.3	8p23.1
	Type of gene	protein-coding	protein-coding
	Description	exosome complex component RRP41exosome complex exonuclease RRP41exosome component Rrp41ribosomal RNA-processing protein 41	endonuclease 8-like 2DNA glycosylase/AP lyase Neil2DNA-(apurinic or apyrimidinic site) lyase Neil2nei endonuclease VIII-like 2nei homolog 2nei-like protein 2
	Modification date	20200313	20200313
	UniProtAcc	Q9NPD3	Q969S2
	Ensembl transtripts involved in fusion gene	ENST00000316052, ENST00000525936,	ENST00000403422, ENST00000284503, ENST00000528323, ENST00000436750, ENST00000455213,
Fusion gene scores	* DoF score	2 X 4 X 2=16	2 X 6 X 3=36
	# samples	3	4
	** MAII score	log2(3/16*10)=0.906890595608518 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: EXOSC4 [Title/Abstract] AND NEIL2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	EXOSC4(145133803)-NEIL2(11637108), # samples:1 EXOSC4(145133802)-NEIL2(11637106), # samples:1 EXOSC4(145133800)-NEIL2(11637105), # samples:1 EXOSC4(145133802)-NEIL2(11637107), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	EXOSC4	GO:0045006	DNA deamination	21255825

Fusion gene breakpoints across EXOSC4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across NEIL2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	MESO	TCGA-UD-AAC4-01A	EXOSC4	chr8	145133802	-	NEIL2	chr8	11637107	+
ChimerDB4	MESO	TCGA-UD-AAC4-01A	EXOSC4	chr8	145133803	+	NEIL2	chr8	11637108	+
ChimerDB4	MESO	TCGA-UD-AAC4	EXOSC4	chr8	145133800	+	NEIL2	chr8	11637105	+
ChimerDB4	MESO	TCGA-UD-AAC4	EXOSC4	chr8	145133802	+	NEIL2	chr8	11637106	+

Top

Fusion Gene ORF analysis for EXOSC4-NEIL2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000316052	ENST00000403422	EXOSC4	chr8	145133802	-	NEIL2	chr8	11637107	+
5CDS-5UTR	ENST00000316052	ENST00000403422	EXOSC4	chr8	145133803	+	NEIL2	chr8	11637108	+
5CDS-5UTR	ENST00000316052	ENST00000403422	EXOSC4	chr8	145133800	+	NEIL2	chr8	11637105	+
5CDS-5UTR	ENST00000316052	ENST00000403422	EXOSC4	chr8	145133802	+	NEIL2	chr8	11637106	+
5CDS-5UTR	ENST00000525936	ENST00000403422	EXOSC4	chr8	145133802	-	NEIL2	chr8	11637107	+
5CDS-5UTR	ENST00000525936	ENST00000403422	EXOSC4	chr8	145133803	+	NEIL2	chr8	11637108	+
5CDS-5UTR	ENST00000525936	ENST00000403422	EXOSC4	chr8	145133800	+	NEIL2	chr8	11637105	+
5CDS-5UTR	ENST00000525936	ENST00000403422	EXOSC4	chr8	145133802	+	NEIL2	chr8	11637106	+
5CDS-intron	ENST00000316052	ENST00000284503	EXOSC4	chr8	145133802	-	NEIL2	chr8	11637107	+
5CDS-intron	ENST00000316052	ENST00000284503	EXOSC4	chr8	145133803	+	NEIL2	chr8	11637108	+
5CDS-intron	ENST00000316052	ENST00000284503	EXOSC4	chr8	145133800	+	NEIL2	chr8	11637105	+
5CDS-intron	ENST00000316052	ENST00000284503	EXOSC4	chr8	145133802	+	NEIL2	chr8	11637106	+
5CDS-intron	ENST00000316052	ENST00000528323	EXOSC4	chr8	145133802	-	NEIL2	chr8	11637107	+
5CDS-intron	ENST00000316052	ENST00000528323	EXOSC4	chr8	145133803	+	NEIL2	chr8	11637108	+
5CDS-intron	ENST00000316052	ENST00000528323	EXOSC4	chr8	145133800	+	NEIL2	chr8	11637105	+
5CDS-intron	ENST00000316052	ENST00000528323	EXOSC4	chr8	145133802	+	NEIL2	chr8	11637106	+
5CDS-intron	ENST00000525936	ENST00000284503	EXOSC4	chr8	145133802	-	NEIL2	chr8	11637107	+
5CDS-intron	ENST00000525936	ENST00000284503	EXOSC4	chr8	145133803	+	NEIL2	chr8	11637108	+
5CDS-intron	ENST00000525936	ENST00000284503	EXOSC4	chr8	145133800	+	NEIL2	chr8	11637105	+
5CDS-intron	ENST00000525936	ENST00000284503	EXOSC4	chr8	145133802	+	NEIL2	chr8	11637106	+
5CDS-intron	ENST00000525936	ENST00000528323	EXOSC4	chr8	145133802	-	NEIL2	chr8	11637107	+
5CDS-intron	ENST00000525936	ENST00000528323	EXOSC4	chr8	145133803	+	NEIL2	chr8	11637108	+
5CDS-intron	ENST00000525936	ENST00000528323	EXOSC4	chr8	145133800	+	NEIL2	chr8	11637105	+
5CDS-intron	ENST00000525936	ENST00000528323	EXOSC4	chr8	145133802	+	NEIL2	chr8	11637106	+
In-frame	ENST00000316052	ENST00000436750	EXOSC4	chr8	145133802	-	NEIL2	chr8	11637107	+
In-frame	ENST00000316052	ENST00000436750	EXOSC4	chr8	145133803	+	NEIL2	chr8	11637108	+
In-frame	ENST00000316052	ENST00000436750	EXOSC4	chr8	145133800	+	NEIL2	chr8	11637105	+
In-frame	ENST00000316052	ENST00000436750	EXOSC4	chr8	145133802	+	NEIL2	chr8	11637106	+
In-frame	ENST00000316052	ENST00000455213	EXOSC4	chr8	145133802	-	NEIL2	chr8	11637107	+
In-frame	ENST00000316052	ENST00000455213	EXOSC4	chr8	145133803	+	NEIL2	chr8	11637108	+
In-frame	ENST00000316052	ENST00000455213	EXOSC4	chr8	145133800	+	NEIL2	chr8	11637105	+
In-frame	ENST00000316052	ENST00000455213	EXOSC4	chr8	145133802	+	NEIL2	chr8	11637106	+
In-frame	ENST00000525936	ENST00000436750	EXOSC4	chr8	145133802	-	NEIL2	chr8	11637107	+
In-frame	ENST00000525936	ENST00000436750	EXOSC4	chr8	145133803	+	NEIL2	chr8	11637108	+
In-frame	ENST00000525936	ENST00000436750	EXOSC4	chr8	145133800	+	NEIL2	chr8	11637105	+
In-frame	ENST00000525936	ENST00000436750	EXOSC4	chr8	145133802	+	NEIL2	chr8	11637106	+
In-frame	ENST00000525936	ENST00000455213	EXOSC4	chr8	145133802	-	NEIL2	chr8	11637107	+
In-frame	ENST00000525936	ENST00000455213	EXOSC4	chr8	145133803	+	NEIL2	chr8	11637108	+
In-frame	ENST00000525936	ENST00000455213	EXOSC4	chr8	145133800	+	NEIL2	chr8	11637105	+
In-frame	ENST00000525936	ENST00000455213	EXOSC4	chr8	145133802	+	NEIL2	chr8	11637106	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000316052	EXOSC4	chr8	145133803	+	ENST00000436750	NEIL2	chr8	11637108	+	2207	274	103	1134	343
ENST00000316052	EXOSC4	chr8	145133803	+	ENST00000455213	NEIL2	chr8	11637108	+	2202	274	103	1134	343
ENST00000525936	EXOSC4	chr8	145133803	+	ENST00000436750	NEIL2	chr8	11637108	+	2185	252	81	1112	343
ENST00000525936	EXOSC4	chr8	145133803	+	ENST00000455213	NEIL2	chr8	11637108	+	2180	252	81	1112	343
ENST00000316052	EXOSC4	chr8	145133802	+	ENST00000436750	NEIL2	chr8	11637106	+	2207	274	103	1134	343
ENST00000316052	EXOSC4	chr8	145133802	+	ENST00000455213	NEIL2	chr8	11637106	+	2202	274	103	1134	343
ENST00000525936	EXOSC4	chr8	145133802	+	ENST00000436750	NEIL2	chr8	11637106	+	2185	252	81	1112	343
ENST00000525936	EXOSC4	chr8	145133802	+	ENST00000455213	NEIL2	chr8	11637106	+	2180	252	81	1112	343
ENST00000316052	EXOSC4	chr8	145133800	+	ENST00000436750	NEIL2	chr8	11637105	+	2207	274	103	1134	343
ENST00000316052	EXOSC4	chr8	145133800	+	ENST00000455213	NEIL2	chr8	11637105	+	2202	274	103	1134	343
ENST00000525936	EXOSC4	chr8	145133800	+	ENST00000436750	NEIL2	chr8	11637105	+	2185	252	81	1112	343
ENST00000525936	EXOSC4	chr8	145133800	+	ENST00000455213	NEIL2	chr8	11637105	+	2180	252	81	1112	343
ENST00000316052	EXOSC4	chr8	145133802	-	ENST00000436750	NEIL2	chr8	11637107	+	2207	274	103	1134	343
ENST00000316052	EXOSC4	chr8	145133802	-	ENST00000455213	NEIL2	chr8	11637107	+	2202	274	103	1134	343
ENST00000525936	EXOSC4	chr8	145133802	-	ENST00000436750	NEIL2	chr8	11637107	+	2185	252	81	1112	343
ENST00000525936	EXOSC4	chr8	145133802	-	ENST00000455213	NEIL2	chr8	11637107	+	2180	252	81	1112	343

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000316052	ENST00000436750	EXOSC4	chr8	145133803	+	NEIL2	chr8	11637108	+	0.006514239	0.99348575
ENST00000316052	ENST00000455213	EXOSC4	chr8	145133803	+	NEIL2	chr8	11637108	+	0.006525775	0.9934742
ENST00000525936	ENST00000436750	EXOSC4	chr8	145133803	+	NEIL2	chr8	11637108	+	0.006518771	0.9934813
ENST00000525936	ENST00000455213	EXOSC4	chr8	145133803	+	NEIL2	chr8	11637108	+	0.006491744	0.9935082
ENST00000316052	ENST00000436750	EXOSC4	chr8	145133802	+	NEIL2	chr8	11637106	+	0.006514239	0.99348575
ENST00000316052	ENST00000455213	EXOSC4	chr8	145133802	+	NEIL2	chr8	11637106	+	0.006525775	0.9934742
ENST00000525936	ENST00000436750	EXOSC4	chr8	145133802	+	NEIL2	chr8	11637106	+	0.006518771	0.9934813
ENST00000525936	ENST00000455213	EXOSC4	chr8	145133802	+	NEIL2	chr8	11637106	+	0.006491744	0.9935082
ENST00000316052	ENST00000436750	EXOSC4	chr8	145133800	+	NEIL2	chr8	11637105	+	0.006514239	0.99348575
ENST00000316052	ENST00000455213	EXOSC4	chr8	145133800	+	NEIL2	chr8	11637105	+	0.006525775	0.9934742
ENST00000525936	ENST00000436750	EXOSC4	chr8	145133800	+	NEIL2	chr8	11637105	+	0.006518771	0.9934813
ENST00000525936	ENST00000455213	EXOSC4	chr8	145133800	+	NEIL2	chr8	11637105	+	0.006491744	0.9935082
ENST00000316052	ENST00000436750	EXOSC4	chr8	145133802	-	NEIL2	chr8	11637107	+	0.006514239	0.99348575
ENST00000316052	ENST00000455213	EXOSC4	chr8	145133802	-	NEIL2	chr8	11637107	+	0.006525775	0.9934742
ENST00000525936	ENST00000436750	EXOSC4	chr8	145133802	-	NEIL2	chr8	11637107	+	0.006518771	0.9934813
ENST00000525936	ENST00000455213	EXOSC4	chr8	145133802	-	NEIL2	chr8	11637107	+	0.006491744	0.9935082

Top

Fusion Genomic Features for EXOSC4-NEIL2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
EXOSC4	chr8	145133802	+	NEIL2	chr8	11637106	+	1.61E-05	0.9999839
EXOSC4	chr8	145133802	+	NEIL2	chr8	11637106	+	1.61E-05	0.9999839
EXOSC4	chr8	145133802	+	NEIL2	chr8	11637106	+	1.61E-05	0.9999839
EXOSC4	chr8	145133802	+	NEIL2	chr8	11637106	+	1.61E-05	0.9999839

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for EXOSC4-NEIL2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:145133803/chr8:11637108)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
EXOSC4 Q9NPD3	NEIL2 Q969S2
FUNCTION: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC4 binds to ARE-containing RNAs. {ECO:0000269\|PubMed:16912217, ECO:0000269\|PubMed:17545563, ECO:0000269\|PubMed:18172165, ECO:0000269\|PubMed:20368444, ECO:0000269\|PubMed:21255825}.	FUNCTION: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Has DNA glycosylase activity towards 5-hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double-stranded DNA (DNA bubbles). Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. {ECO:0000269\|PubMed:12097317, ECO:0000269\|PubMed:14522990, ECO:0000269\|PubMed:15175427, ECO:0000269\|PubMed:15339932}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

NEIL2

chr8:145133800

chr8:11637105

ENST00000284503

284_320

333.0

Zinc finger

FPG-type

Tgene

NEIL2

chr8:145133800

chr8:11637105

ENST00000403422

284_320

272.0

Zinc finger

FPG-type

Tgene

NEIL2

chr8:145133800

chr8:11637105

ENST00000436750

284_320

333.0

Zinc finger

FPG-type

Tgene

NEIL2

chr8:145133800

chr8:11637105

ENST00000455213

284_320

333.0

Zinc finger

FPG-type

Tgene

NEIL2

chr8:145133800

chr8:11637105

ENST00000528323

284_320

217.0

Zinc finger

FPG-type

Tgene

NEIL2

chr8:145133802

chr8:11637106

ENST00000284503

284_320

333.0

Zinc finger

FPG-type

Tgene

NEIL2

chr8:145133802

chr8:11637106

ENST00000403422

284_320

272.0

Zinc finger

FPG-type

Tgene

NEIL2

chr8:145133802

chr8:11637106

ENST00000436750

284_320

333.0

Zinc finger

FPG-type

Tgene

NEIL2

chr8:145133802

chr8:11637106

ENST00000455213

284_320

333.0

Zinc finger

FPG-type

Tgene

NEIL2

chr8:145133802

chr8:11637106

ENST00000528323

284_320

217.0

Zinc finger

FPG-type

Tgene

NEIL2

chr8:145133802

chr8:11637107

ENST00000284503

284_320

333.0

Zinc finger

FPG-type

Tgene

NEIL2

chr8:145133802

chr8:11637107

ENST00000403422

284_320

272.0

Zinc finger

FPG-type

Tgene

NEIL2

chr8:145133802

chr8:11637107

ENST00000436750

284_320

333.0

Zinc finger

FPG-type

Tgene

NEIL2

chr8:145133802

chr8:11637107

ENST00000455213

284_320

333.0

Zinc finger

FPG-type

Tgene

NEIL2

chr8:145133802

chr8:11637107

ENST00000528323

284_320

217.0

Zinc finger

FPG-type

Tgene

NEIL2

chr8:145133803

chr8:11637108

ENST00000284503

284_320

333.0

Zinc finger

FPG-type

Tgene

NEIL2

chr8:145133803

chr8:11637108

ENST00000403422

284_320

272.0

Zinc finger

FPG-type

Tgene

NEIL2

chr8:145133803

chr8:11637108

ENST00000436750

284_320

333.0

Zinc finger

FPG-type

Tgene

NEIL2

chr8:145133803

chr8:11637108

ENST00000455213

284_320

333.0

Zinc finger

FPG-type

Tgene

NEIL2

chr8:145133803

chr8:11637108

ENST00000528323

284_320

217.0

Zinc finger

FPG-type

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Top

Fusion Gene Sequence for EXOSC4-NEIL2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>27981_27981_1_EXOSC4-NEIL2_EXOSC4_chr8_145133800_ENST00000316052_NEIL2_chr8_11637105_ENST00000436750_length(transcript)=2207nt_BP=274nt
ACCTCCGGAAACCGTAGATTCCGGGCGGTCGGAGCCGCCGGGAGCTGTAGTTCTCCCGCGGCTCAGAGAAGTAGGCAGAGAGCGGACCTG
GCGGCCGGGCAGCATGGCGGGGCTGGAGCTCTTGTCGGACCAGGGCTACCGGGTGGACGGGCGGCGCGCCGGGGAGCTGCGCAAGATCCA
GGCGCGGATGGGCGTGTTCGCGCAGGCTGACGGCTCGGCCTACATTGAGCAGGGCAACACCAAGGCACTGGCTGTGGTCTACGGCCCGCA
CGAGGTCCATGGAAAGAAATTATTCCTTAGATTTGATCTAGATGAAGAAATGGGGCCCCCTGGCAGCAGCCCAACACCAGAGCCTCCACA
AAAAGAAGTGCAGAAGGAAGGGGCTGCGGACCCAAAGCAGGTCGGGGAGCCCAGCGGGCAGAAGACCCTTGATGGATCCTCACGGTCTGC
AGAGCTCGTCCCCCAGGGCGAGGATGATTCTGAGTATTTGGAGAGAGACGCCCCTGCAGGAGATGCTGGGAGGTGGCTGCGTGTCAGCTT
TGGTTTGTTTGGCAGCGTTTGGGTGAACGATTTCTCCAGAGCCAAGAAAGCCAACAAGAGGGGGGACTGGAGGGACCCTTCCCCGAGGTT
GGTCCTGCACTTTGGTGGTGGTGGCTTCCTGGCATTTTATAATTGTCAGTTGTCTTGGAGCTCTTCCCCAGTGGTCACACCCACCTGTGA
CATCCTGTCTGAGAAGTTCCATCGAGGACAAGCCTTAGAAGCTCTAGGCCAGGCTCAGCCTGTCTGCTATACACTGCTGGACCAGAGATA
CTTCTCAGGGCTAGGGAACATCATTAAGAATGAAGCCTTGTACAGAGCTGGGATCCATCCCCTTTCTCTCGGTTCAGTCCTGAGTGCCTC
GCGTCGGGAGGTCCTGGTGGATCACGTGGTGGAGTTCAGTACAGCCTGGCTGCAGGGCAAGTTCCAAGGCAGACCGCAGCACACACAGGT
CTACCAGAAAGAACAGTGCCCTGCTGGCCACCAGGTCATGAAGGAGGCGTTTGGGCCCGAAGATGGGTTACAGAGGCTCACCTGGTGGTG
CCCGCAGTGCCAGCCCCAGTTGTCAGAGGAGCCAGAGCAGTGCCAGTTCTCCTAAGGAGCTGGTGGTGCTCCTCACGGAACCTTGCCGCT
TGGGGAACCTGACGTCTAAGTGTCCAGAAAGGAGGATGTGGGCAGGGACGGGGTACAGAGGATAGTGTGGGTCAGAGGTGCCAGTAGTAT
AATATTCGTCTCCCTGGAGTTATGTTGAAGGCAGAGTTTTCATAGGGTTAGATTTTTTTTATCCTTTTCTAGTTCAGTTAATTCATCCTG
TTGAATTGCACCATCGTGAAAGATGGGAAAAATCGTGATGATGGGTAAGGGGAAAACTTCCCGGAAGGCAATGGGGCAAGGAAAAAGAAA
GCCTATGGGAAATGGCTGTGCTCCCAACATAGCTTTGCAGATGATGTGGGTTTTTTTTTTTTTTTTGGTTGTTTGTTTTGAGAGAGAGTC
TTGCTCTGTCTCCCTGGCTAGGGTGTGGTGGTGTGATCTTGGCTCACGGCAGCCTTGCCCTCCCTGGCTCAAGCAGTCTTCATCTCAGCC
TCCAGAGTAGCTGGGACTACAGGCATGTGATATGATGCTCGGCTGATTTTTGTTTACTTTTTAGAGAGATGGGGTCTTGCCATATTTGCC
AGGCTGGTTTGAACTCCTACAACTCAAGCATTCCTCCCACCTTGGTCTCCCAAAATGTTGGGACCACGGGTGTGAGCCACCGCGCCCAGC
TAGCTCCTGTGTTTTGTTTTTGTTTTGTAACTTTGGTTGATGTTAAGGCCCTCCATTTTGGAAAGCAGGAAAACAGGATTTTTTTTTTTT
TATCTTGTTCCCTGGAGGATCCAGGGATGAGGATAGAGTGGCCTGAGAGCAGTGCTTGGATTCAGCCTCCTGCTGGGTCCTTCTGCTGGA
TACAGGCACCAAGAGGCGGTCGTGGAGCAGGGAGCTGCGCCTTCCTGGGGTGCCCGGTGGTGTGTAGAGAAAAGCTGCTTGTTTACTCCT
TAAGTCAATGTATTGGTGACTGTTGATTTGTTGAACAATTCAGGAATCAAGGGCTGTGGAGAAACTCCCTCATGTTGTTGGCAACAGGTG

>27981_27981_1_EXOSC4-NEIL2_EXOSC4_chr8_145133800_ENST00000316052_NEIL2_chr8_11637105_ENST00000436750_length(amino acids)=343AA_BP=57
MAGLELLSDQGYRVDGRRAGELRKIQARMGVFAQADGSAYIEQGNTKALAVVYGPHEVHGKKLFLRFDLDEEMGPPGSSPTPEPPQKEVQ
KEGAADPKQVGEPSGQKTLDGSSRSAELVPQGEDDSEYLERDAPAGDAGRWLRVSFGLFGSVWVNDFSRAKKANKRGDWRDPSPRLVLHF
GGGGFLAFYNCQLSWSSSPVVTPTCDILSEKFHRGQALEALGQAQPVCYTLLDQRYFSGLGNIIKNEALYRAGIHPLSLGSVLSASRREV

--------------------------------------------------------------
>27981_27981_2_EXOSC4-NEIL2_EXOSC4_chr8_145133800_ENST00000316052_NEIL2_chr8_11637105_ENST00000455213_length(transcript)=2202nt_BP=274nt
ACCTCCGGAAACCGTAGATTCCGGGCGGTCGGAGCCGCCGGGAGCTGTAGTTCTCCCGCGGCTCAGAGAAGTAGGCAGAGAGCGGACCTG
GCGGCCGGGCAGCATGGCGGGGCTGGAGCTCTTGTCGGACCAGGGCTACCGGGTGGACGGGCGGCGCGCCGGGGAGCTGCGCAAGATCCA
GGCGCGGATGGGCGTGTTCGCGCAGGCTGACGGCTCGGCCTACATTGAGCAGGGCAACACCAAGGCACTGGCTGTGGTCTACGGCCCGCA
CGAGGTCCATGGAAAGAAATTATTCCTTAGATTTGATCTAGATGAAGAAATGGGGCCCCCTGGCAGCAGCCCAACACCAGAGCCTCCACA
AAAAGAAGTGCAGAAGGAAGGGGCTGCGGACCCAAAGCAGGTCGGGGAGCCCAGCGGGCAGAAGACCCTTGATGGATCCTCACGGTCTGC
AGAGCTCGTCCCCCAGGGCGAGGATGATTCTGAGTATTTGGAGAGAGACGCCCCTGCAGGAGATGCTGGGAGGTGGCTGCGTGTCAGCTT
TGGTTTGTTTGGCAGCGTTTGGGTGAACGATTTCTCCAGAGCCAAGAAAGCCAACAAGAGGGGGGACTGGAGGGACCCTTCCCCGAGGTT
GGTCCTGCACTTTGGTGGTGGTGGCTTCCTGGCATTTTATAATTGTCAGTTGTCTTGGAGCTCTTCCCCAGTGGTCACACCCACCTGTGA
CATCCTGTCTGAGAAGTTCCATCGAGGACAAGCCTTAGAAGCTCTAGGCCAGGCTCAGCCTGTCTGCTATACACTGCTGGACCAGAGATA
CTTCTCAGGGCTAGGGAACATCATTAAGAATGAAGCCTTGTACAGAGCTGGGATCCATCCCCTTTCTCTCGGTTCAGTCCTGAGTGCCTC
GCGTCGGGAGGTCCTGGTGGATCACGTGGTGGAGTTCAGTACAGCCTGGCTGCAGGGCAAGTTCCAAGGCAGACCGCAGCACACACAGGT
CTACCAGAAAGAACAGTGCCCTGCTGGCCACCAGGTCATGAAGGAGGCGTTTGGGCCCGAAGATGGGTTACAGAGGCTCACCTGGTGGTG
CCCGCAGTGCCAGCCCCAGTTGTCAGAGGAGCCAGAGCAGTGCCAGTTCTCCTAAGGAGCTGGTGGTGCTCCTCACGGAACCTTGCCGCT
TGGGGAACCTGACGTCTAAGTGTCCAGAAAGGAGGATGTGGGCAGGGACGGGGTACAGAGGATAGTGTGGGTCAGAGGTGCCAGTAGTAT
AATATTCGTCTCCCTGGAGTTATGTTGAAGGCAGAGTTTTCATAGGGTTAGATTTTTTTTATCCTTTTCTAGTTCAGTTAATTCATCCTG
TTGAATTGCACCATCGTGAAAGATGGGAAAAATCGTGATGATGGGTAAGGGGAAAACTTCCCGGAAGGCAATGGGGCAAGGAAAAAGAAA
GCCTATGGGAAATGGCTGTGCTCCCAACATAGCTTTGCAGATGATGTGGGTTTTTTTTTTTTTTTTGGTTGTTTGTTTTGAGAGAGAGTC
TTGCTCTGTCTCCCTGGCTAGGGTGTGGTGGTGTGATCTTGGCTCACGGCAGCCTTGCCCTCCCTGGCTCAAGCAGTCTTCATCTCAGCC
TCCAGAGTAGCTGGGACTACAGGCATGTGATATGATGCTCGGCTGATTTTTGTTTACTTTTTAGAGAGATGGGGTCTTGCCATATTTGCC
AGGCTGGTTTGAACTCCTACAACTCAAGCATTCCTCCCACCTTGGTCTCCCAAAATGTTGGGACCACGGGTGTGAGCCACCGCGCCCAGC
TAGCTCCTGTGTTTTGTTTTTGTTTTGTAACTTTGGTTGATGTTAAGGCCCTCCATTTTGGAAAGCAGGAAAACAGGATTTTTTTTTTTT
TATCTTGTTCCCTGGAGGATCCAGGGATGAGGATAGAGTGGCCTGAGAGCAGTGCTTGGATTCAGCCTCCTGCTGGGTCCTTCTGCTGGA
TACAGGCACCAAGAGGCGGTCGTGGAGCAGGGAGCTGCGCCTTCCTGGGGTGCCCGGTGGTGTGTAGAGAAAAGCTGCTTGTTTACTCCT
TAAGTCAATGTATTGGTGACTGTTGATTTGTTGAACAATTCAGGAATCAAGGGCTGTGGAGAAACTCCCTCATGTTGTTGGCAACAGGTG

>27981_27981_2_EXOSC4-NEIL2_EXOSC4_chr8_145133800_ENST00000316052_NEIL2_chr8_11637105_ENST00000455213_length(amino acids)=343AA_BP=57
MAGLELLSDQGYRVDGRRAGELRKIQARMGVFAQADGSAYIEQGNTKALAVVYGPHEVHGKKLFLRFDLDEEMGPPGSSPTPEPPQKEVQ
KEGAADPKQVGEPSGQKTLDGSSRSAELVPQGEDDSEYLERDAPAGDAGRWLRVSFGLFGSVWVNDFSRAKKANKRGDWRDPSPRLVLHF
GGGGFLAFYNCQLSWSSSPVVTPTCDILSEKFHRGQALEALGQAQPVCYTLLDQRYFSGLGNIIKNEALYRAGIHPLSLGSVLSASRREV

--------------------------------------------------------------
>27981_27981_3_EXOSC4-NEIL2_EXOSC4_chr8_145133800_ENST00000525936_NEIL2_chr8_11637105_ENST00000436750_length(transcript)=2185nt_BP=252nt
GGGCGGTCGGAGCCGCCGGGAGCTGTAGTTCTCCCGCGGCTCAGAGAAGTAGGCAGAGAGCGGACCTGGCGGCCGGGCAGCATGGCGGGG
CTGGAGCTCTTGTCGGACCAGGGCTACCGGGTGGACGGGCGGCGCGCCGGGGAGCTGCGCAAGATCCAGGCGCGGATGGGCGTGTTCGCG
CAGGCTGACGGCTCGGCCTACATTGAGCAGGGCAACACCAAGGCACTGGCTGTGGTCTACGGCCCGCACGAGGTCCATGGAAAGAAATTA
TTCCTTAGATTTGATCTAGATGAAGAAATGGGGCCCCCTGGCAGCAGCCCAACACCAGAGCCTCCACAAAAAGAAGTGCAGAAGGAAGGG
GCTGCGGACCCAAAGCAGGTCGGGGAGCCCAGCGGGCAGAAGACCCTTGATGGATCCTCACGGTCTGCAGAGCTCGTCCCCCAGGGCGAG
GATGATTCTGAGTATTTGGAGAGAGACGCCCCTGCAGGAGATGCTGGGAGGTGGCTGCGTGTCAGCTTTGGTTTGTTTGGCAGCGTTTGG
GTGAACGATTTCTCCAGAGCCAAGAAAGCCAACAAGAGGGGGGACTGGAGGGACCCTTCCCCGAGGTTGGTCCTGCACTTTGGTGGTGGT
GGCTTCCTGGCATTTTATAATTGTCAGTTGTCTTGGAGCTCTTCCCCAGTGGTCACACCCACCTGTGACATCCTGTCTGAGAAGTTCCAT
CGAGGACAAGCCTTAGAAGCTCTAGGCCAGGCTCAGCCTGTCTGCTATACACTGCTGGACCAGAGATACTTCTCAGGGCTAGGGAACATC
ATTAAGAATGAAGCCTTGTACAGAGCTGGGATCCATCCCCTTTCTCTCGGTTCAGTCCTGAGTGCCTCGCGTCGGGAGGTCCTGGTGGAT
CACGTGGTGGAGTTCAGTACAGCCTGGCTGCAGGGCAAGTTCCAAGGCAGACCGCAGCACACACAGGTCTACCAGAAAGAACAGTGCCCT
GCTGGCCACCAGGTCATGAAGGAGGCGTTTGGGCCCGAAGATGGGTTACAGAGGCTCACCTGGTGGTGCCCGCAGTGCCAGCCCCAGTTG
TCAGAGGAGCCAGAGCAGTGCCAGTTCTCCTAAGGAGCTGGTGGTGCTCCTCACGGAACCTTGCCGCTTGGGGAACCTGACGTCTAAGTG
TCCAGAAAGGAGGATGTGGGCAGGGACGGGGTACAGAGGATAGTGTGGGTCAGAGGTGCCAGTAGTATAATATTCGTCTCCCTGGAGTTA
TGTTGAAGGCAGAGTTTTCATAGGGTTAGATTTTTTTTATCCTTTTCTAGTTCAGTTAATTCATCCTGTTGAATTGCACCATCGTGAAAG
ATGGGAAAAATCGTGATGATGGGTAAGGGGAAAACTTCCCGGAAGGCAATGGGGCAAGGAAAAAGAAAGCCTATGGGAAATGGCTGTGCT
CCCAACATAGCTTTGCAGATGATGTGGGTTTTTTTTTTTTTTTTGGTTGTTTGTTTTGAGAGAGAGTCTTGCTCTGTCTCCCTGGCTAGG
GTGTGGTGGTGTGATCTTGGCTCACGGCAGCCTTGCCCTCCCTGGCTCAAGCAGTCTTCATCTCAGCCTCCAGAGTAGCTGGGACTACAG
GCATGTGATATGATGCTCGGCTGATTTTTGTTTACTTTTTAGAGAGATGGGGTCTTGCCATATTTGCCAGGCTGGTTTGAACTCCTACAA
CTCAAGCATTCCTCCCACCTTGGTCTCCCAAAATGTTGGGACCACGGGTGTGAGCCACCGCGCCCAGCTAGCTCCTGTGTTTTGTTTTTG
TTTTGTAACTTTGGTTGATGTTAAGGCCCTCCATTTTGGAAAGCAGGAAAACAGGATTTTTTTTTTTTTATCTTGTTCCCTGGAGGATCC
AGGGATGAGGATAGAGTGGCCTGAGAGCAGTGCTTGGATTCAGCCTCCTGCTGGGTCCTTCTGCTGGATACAGGCACCAAGAGGCGGTCG
TGGAGCAGGGAGCTGCGCCTTCCTGGGGTGCCCGGTGGTGTGTAGAGAAAAGCTGCTTGTTTACTCCTTAAGTCAATGTATTGGTGACTG
TTGATTTGTTGAACAATTCAGGAATCAAGGGCTGTGGAGAAACTCCCTCATGTTGTTGGCAACAGGTGAATGAACCTAGAGCGGTGACAT

>27981_27981_3_EXOSC4-NEIL2_EXOSC4_chr8_145133800_ENST00000525936_NEIL2_chr8_11637105_ENST00000436750_length(amino acids)=343AA_BP=57
MAGLELLSDQGYRVDGRRAGELRKIQARMGVFAQADGSAYIEQGNTKALAVVYGPHEVHGKKLFLRFDLDEEMGPPGSSPTPEPPQKEVQ
KEGAADPKQVGEPSGQKTLDGSSRSAELVPQGEDDSEYLERDAPAGDAGRWLRVSFGLFGSVWVNDFSRAKKANKRGDWRDPSPRLVLHF
GGGGFLAFYNCQLSWSSSPVVTPTCDILSEKFHRGQALEALGQAQPVCYTLLDQRYFSGLGNIIKNEALYRAGIHPLSLGSVLSASRREV

--------------------------------------------------------------
>27981_27981_4_EXOSC4-NEIL2_EXOSC4_chr8_145133800_ENST00000525936_NEIL2_chr8_11637105_ENST00000455213_length(transcript)=2180nt_BP=252nt
GGGCGGTCGGAGCCGCCGGGAGCTGTAGTTCTCCCGCGGCTCAGAGAAGTAGGCAGAGAGCGGACCTGGCGGCCGGGCAGCATGGCGGGG
CTGGAGCTCTTGTCGGACCAGGGCTACCGGGTGGACGGGCGGCGCGCCGGGGAGCTGCGCAAGATCCAGGCGCGGATGGGCGTGTTCGCG
CAGGCTGACGGCTCGGCCTACATTGAGCAGGGCAACACCAAGGCACTGGCTGTGGTCTACGGCCCGCACGAGGTCCATGGAAAGAAATTA
TTCCTTAGATTTGATCTAGATGAAGAAATGGGGCCCCCTGGCAGCAGCCCAACACCAGAGCCTCCACAAAAAGAAGTGCAGAAGGAAGGG
GCTGCGGACCCAAAGCAGGTCGGGGAGCCCAGCGGGCAGAAGACCCTTGATGGATCCTCACGGTCTGCAGAGCTCGTCCCCCAGGGCGAG
GATGATTCTGAGTATTTGGAGAGAGACGCCCCTGCAGGAGATGCTGGGAGGTGGCTGCGTGTCAGCTTTGGTTTGTTTGGCAGCGTTTGG
GTGAACGATTTCTCCAGAGCCAAGAAAGCCAACAAGAGGGGGGACTGGAGGGACCCTTCCCCGAGGTTGGTCCTGCACTTTGGTGGTGGT
GGCTTCCTGGCATTTTATAATTGTCAGTTGTCTTGGAGCTCTTCCCCAGTGGTCACACCCACCTGTGACATCCTGTCTGAGAAGTTCCAT
CGAGGACAAGCCTTAGAAGCTCTAGGCCAGGCTCAGCCTGTCTGCTATACACTGCTGGACCAGAGATACTTCTCAGGGCTAGGGAACATC
ATTAAGAATGAAGCCTTGTACAGAGCTGGGATCCATCCCCTTTCTCTCGGTTCAGTCCTGAGTGCCTCGCGTCGGGAGGTCCTGGTGGAT
CACGTGGTGGAGTTCAGTACAGCCTGGCTGCAGGGCAAGTTCCAAGGCAGACCGCAGCACACACAGGTCTACCAGAAAGAACAGTGCCCT
GCTGGCCACCAGGTCATGAAGGAGGCGTTTGGGCCCGAAGATGGGTTACAGAGGCTCACCTGGTGGTGCCCGCAGTGCCAGCCCCAGTTG
TCAGAGGAGCCAGAGCAGTGCCAGTTCTCCTAAGGAGCTGGTGGTGCTCCTCACGGAACCTTGCCGCTTGGGGAACCTGACGTCTAAGTG
TCCAGAAAGGAGGATGTGGGCAGGGACGGGGTACAGAGGATAGTGTGGGTCAGAGGTGCCAGTAGTATAATATTCGTCTCCCTGGAGTTA
TGTTGAAGGCAGAGTTTTCATAGGGTTAGATTTTTTTTATCCTTTTCTAGTTCAGTTAATTCATCCTGTTGAATTGCACCATCGTGAAAG
ATGGGAAAAATCGTGATGATGGGTAAGGGGAAAACTTCCCGGAAGGCAATGGGGCAAGGAAAAAGAAAGCCTATGGGAAATGGCTGTGCT
CCCAACATAGCTTTGCAGATGATGTGGGTTTTTTTTTTTTTTTTGGTTGTTTGTTTTGAGAGAGAGTCTTGCTCTGTCTCCCTGGCTAGG
GTGTGGTGGTGTGATCTTGGCTCACGGCAGCCTTGCCCTCCCTGGCTCAAGCAGTCTTCATCTCAGCCTCCAGAGTAGCTGGGACTACAG
GCATGTGATATGATGCTCGGCTGATTTTTGTTTACTTTTTAGAGAGATGGGGTCTTGCCATATTTGCCAGGCTGGTTTGAACTCCTACAA
CTCAAGCATTCCTCCCACCTTGGTCTCCCAAAATGTTGGGACCACGGGTGTGAGCCACCGCGCCCAGCTAGCTCCTGTGTTTTGTTTTTG
TTTTGTAACTTTGGTTGATGTTAAGGCCCTCCATTTTGGAAAGCAGGAAAACAGGATTTTTTTTTTTTTATCTTGTTCCCTGGAGGATCC
AGGGATGAGGATAGAGTGGCCTGAGAGCAGTGCTTGGATTCAGCCTCCTGCTGGGTCCTTCTGCTGGATACAGGCACCAAGAGGCGGTCG
TGGAGCAGGGAGCTGCGCCTTCCTGGGGTGCCCGGTGGTGTGTAGAGAAAAGCTGCTTGTTTACTCCTTAAGTCAATGTATTGGTGACTG
TTGATTTGTTGAACAATTCAGGAATCAAGGGCTGTGGAGAAACTCCCTCATGTTGTTGGCAACAGGTGAATGAACCTAGAGCGGTGACAT

>27981_27981_4_EXOSC4-NEIL2_EXOSC4_chr8_145133800_ENST00000525936_NEIL2_chr8_11637105_ENST00000455213_length(amino acids)=343AA_BP=57
MAGLELLSDQGYRVDGRRAGELRKIQARMGVFAQADGSAYIEQGNTKALAVVYGPHEVHGKKLFLRFDLDEEMGPPGSSPTPEPPQKEVQ
KEGAADPKQVGEPSGQKTLDGSSRSAELVPQGEDDSEYLERDAPAGDAGRWLRVSFGLFGSVWVNDFSRAKKANKRGDWRDPSPRLVLHF
GGGGFLAFYNCQLSWSSSPVVTPTCDILSEKFHRGQALEALGQAQPVCYTLLDQRYFSGLGNIIKNEALYRAGIHPLSLGSVLSASRREV

--------------------------------------------------------------
>27981_27981_5_EXOSC4-NEIL2_EXOSC4_chr8_145133802_ENST00000316052_NEIL2_chr8_11637106_ENST00000436750_length(transcript)=2207nt_BP=274nt
ACCTCCGGAAACCGTAGATTCCGGGCGGTCGGAGCCGCCGGGAGCTGTAGTTCTCCCGCGGCTCAGAGAAGTAGGCAGAGAGCGGACCTG
GCGGCCGGGCAGCATGGCGGGGCTGGAGCTCTTGTCGGACCAGGGCTACCGGGTGGACGGGCGGCGCGCCGGGGAGCTGCGCAAGATCCA
GGCGCGGATGGGCGTGTTCGCGCAGGCTGACGGCTCGGCCTACATTGAGCAGGGCAACACCAAGGCACTGGCTGTGGTCTACGGCCCGCA
CGAGGTCCATGGAAAGAAATTATTCCTTAGATTTGATCTAGATGAAGAAATGGGGCCCCCTGGCAGCAGCCCAACACCAGAGCCTCCACA
AAAAGAAGTGCAGAAGGAAGGGGCTGCGGACCCAAAGCAGGTCGGGGAGCCCAGCGGGCAGAAGACCCTTGATGGATCCTCACGGTCTGC
AGAGCTCGTCCCCCAGGGCGAGGATGATTCTGAGTATTTGGAGAGAGACGCCCCTGCAGGAGATGCTGGGAGGTGGCTGCGTGTCAGCTT
TGGTTTGTTTGGCAGCGTTTGGGTGAACGATTTCTCCAGAGCCAAGAAAGCCAACAAGAGGGGGGACTGGAGGGACCCTTCCCCGAGGTT
GGTCCTGCACTTTGGTGGTGGTGGCTTCCTGGCATTTTATAATTGTCAGTTGTCTTGGAGCTCTTCCCCAGTGGTCACACCCACCTGTGA
CATCCTGTCTGAGAAGTTCCATCGAGGACAAGCCTTAGAAGCTCTAGGCCAGGCTCAGCCTGTCTGCTATACACTGCTGGACCAGAGATA
CTTCTCAGGGCTAGGGAACATCATTAAGAATGAAGCCTTGTACAGAGCTGGGATCCATCCCCTTTCTCTCGGTTCAGTCCTGAGTGCCTC
GCGTCGGGAGGTCCTGGTGGATCACGTGGTGGAGTTCAGTACAGCCTGGCTGCAGGGCAAGTTCCAAGGCAGACCGCAGCACACACAGGT
CTACCAGAAAGAACAGTGCCCTGCTGGCCACCAGGTCATGAAGGAGGCGTTTGGGCCCGAAGATGGGTTACAGAGGCTCACCTGGTGGTG
CCCGCAGTGCCAGCCCCAGTTGTCAGAGGAGCCAGAGCAGTGCCAGTTCTCCTAAGGAGCTGGTGGTGCTCCTCACGGAACCTTGCCGCT
TGGGGAACCTGACGTCTAAGTGTCCAGAAAGGAGGATGTGGGCAGGGACGGGGTACAGAGGATAGTGTGGGTCAGAGGTGCCAGTAGTAT
AATATTCGTCTCCCTGGAGTTATGTTGAAGGCAGAGTTTTCATAGGGTTAGATTTTTTTTATCCTTTTCTAGTTCAGTTAATTCATCCTG
TTGAATTGCACCATCGTGAAAGATGGGAAAAATCGTGATGATGGGTAAGGGGAAAACTTCCCGGAAGGCAATGGGGCAAGGAAAAAGAAA
GCCTATGGGAAATGGCTGTGCTCCCAACATAGCTTTGCAGATGATGTGGGTTTTTTTTTTTTTTTTGGTTGTTTGTTTTGAGAGAGAGTC
TTGCTCTGTCTCCCTGGCTAGGGTGTGGTGGTGTGATCTTGGCTCACGGCAGCCTTGCCCTCCCTGGCTCAAGCAGTCTTCATCTCAGCC
TCCAGAGTAGCTGGGACTACAGGCATGTGATATGATGCTCGGCTGATTTTTGTTTACTTTTTAGAGAGATGGGGTCTTGCCATATTTGCC
AGGCTGGTTTGAACTCCTACAACTCAAGCATTCCTCCCACCTTGGTCTCCCAAAATGTTGGGACCACGGGTGTGAGCCACCGCGCCCAGC
TAGCTCCTGTGTTTTGTTTTTGTTTTGTAACTTTGGTTGATGTTAAGGCCCTCCATTTTGGAAAGCAGGAAAACAGGATTTTTTTTTTTT
TATCTTGTTCCCTGGAGGATCCAGGGATGAGGATAGAGTGGCCTGAGAGCAGTGCTTGGATTCAGCCTCCTGCTGGGTCCTTCTGCTGGA
TACAGGCACCAAGAGGCGGTCGTGGAGCAGGGAGCTGCGCCTTCCTGGGGTGCCCGGTGGTGTGTAGAGAAAAGCTGCTTGTTTACTCCT
TAAGTCAATGTATTGGTGACTGTTGATTTGTTGAACAATTCAGGAATCAAGGGCTGTGGAGAAACTCCCTCATGTTGTTGGCAACAGGTG

>27981_27981_5_EXOSC4-NEIL2_EXOSC4_chr8_145133802_ENST00000316052_NEIL2_chr8_11637106_ENST00000436750_length(amino acids)=343AA_BP=57
MAGLELLSDQGYRVDGRRAGELRKIQARMGVFAQADGSAYIEQGNTKALAVVYGPHEVHGKKLFLRFDLDEEMGPPGSSPTPEPPQKEVQ
KEGAADPKQVGEPSGQKTLDGSSRSAELVPQGEDDSEYLERDAPAGDAGRWLRVSFGLFGSVWVNDFSRAKKANKRGDWRDPSPRLVLHF
GGGGFLAFYNCQLSWSSSPVVTPTCDILSEKFHRGQALEALGQAQPVCYTLLDQRYFSGLGNIIKNEALYRAGIHPLSLGSVLSASRREV

--------------------------------------------------------------
>27981_27981_6_EXOSC4-NEIL2_EXOSC4_chr8_145133802_ENST00000316052_NEIL2_chr8_11637106_ENST00000455213_length(transcript)=2202nt_BP=274nt
ACCTCCGGAAACCGTAGATTCCGGGCGGTCGGAGCCGCCGGGAGCTGTAGTTCTCCCGCGGCTCAGAGAAGTAGGCAGAGAGCGGACCTG
GCGGCCGGGCAGCATGGCGGGGCTGGAGCTCTTGTCGGACCAGGGCTACCGGGTGGACGGGCGGCGCGCCGGGGAGCTGCGCAAGATCCA
GGCGCGGATGGGCGTGTTCGCGCAGGCTGACGGCTCGGCCTACATTGAGCAGGGCAACACCAAGGCACTGGCTGTGGTCTACGGCCCGCA
CGAGGTCCATGGAAAGAAATTATTCCTTAGATTTGATCTAGATGAAGAAATGGGGCCCCCTGGCAGCAGCCCAACACCAGAGCCTCCACA
AAAAGAAGTGCAGAAGGAAGGGGCTGCGGACCCAAAGCAGGTCGGGGAGCCCAGCGGGCAGAAGACCCTTGATGGATCCTCACGGTCTGC
AGAGCTCGTCCCCCAGGGCGAGGATGATTCTGAGTATTTGGAGAGAGACGCCCCTGCAGGAGATGCTGGGAGGTGGCTGCGTGTCAGCTT
TGGTTTGTTTGGCAGCGTTTGGGTGAACGATTTCTCCAGAGCCAAGAAAGCCAACAAGAGGGGGGACTGGAGGGACCCTTCCCCGAGGTT
GGTCCTGCACTTTGGTGGTGGTGGCTTCCTGGCATTTTATAATTGTCAGTTGTCTTGGAGCTCTTCCCCAGTGGTCACACCCACCTGTGA
CATCCTGTCTGAGAAGTTCCATCGAGGACAAGCCTTAGAAGCTCTAGGCCAGGCTCAGCCTGTCTGCTATACACTGCTGGACCAGAGATA
CTTCTCAGGGCTAGGGAACATCATTAAGAATGAAGCCTTGTACAGAGCTGGGATCCATCCCCTTTCTCTCGGTTCAGTCCTGAGTGCCTC
GCGTCGGGAGGTCCTGGTGGATCACGTGGTGGAGTTCAGTACAGCCTGGCTGCAGGGCAAGTTCCAAGGCAGACCGCAGCACACACAGGT
CTACCAGAAAGAACAGTGCCCTGCTGGCCACCAGGTCATGAAGGAGGCGTTTGGGCCCGAAGATGGGTTACAGAGGCTCACCTGGTGGTG
CCCGCAGTGCCAGCCCCAGTTGTCAGAGGAGCCAGAGCAGTGCCAGTTCTCCTAAGGAGCTGGTGGTGCTCCTCACGGAACCTTGCCGCT
TGGGGAACCTGACGTCTAAGTGTCCAGAAAGGAGGATGTGGGCAGGGACGGGGTACAGAGGATAGTGTGGGTCAGAGGTGCCAGTAGTAT
AATATTCGTCTCCCTGGAGTTATGTTGAAGGCAGAGTTTTCATAGGGTTAGATTTTTTTTATCCTTTTCTAGTTCAGTTAATTCATCCTG
TTGAATTGCACCATCGTGAAAGATGGGAAAAATCGTGATGATGGGTAAGGGGAAAACTTCCCGGAAGGCAATGGGGCAAGGAAAAAGAAA
GCCTATGGGAAATGGCTGTGCTCCCAACATAGCTTTGCAGATGATGTGGGTTTTTTTTTTTTTTTTGGTTGTTTGTTTTGAGAGAGAGTC
TTGCTCTGTCTCCCTGGCTAGGGTGTGGTGGTGTGATCTTGGCTCACGGCAGCCTTGCCCTCCCTGGCTCAAGCAGTCTTCATCTCAGCC
TCCAGAGTAGCTGGGACTACAGGCATGTGATATGATGCTCGGCTGATTTTTGTTTACTTTTTAGAGAGATGGGGTCTTGCCATATTTGCC
AGGCTGGTTTGAACTCCTACAACTCAAGCATTCCTCCCACCTTGGTCTCCCAAAATGTTGGGACCACGGGTGTGAGCCACCGCGCCCAGC
TAGCTCCTGTGTTTTGTTTTTGTTTTGTAACTTTGGTTGATGTTAAGGCCCTCCATTTTGGAAAGCAGGAAAACAGGATTTTTTTTTTTT
TATCTTGTTCCCTGGAGGATCCAGGGATGAGGATAGAGTGGCCTGAGAGCAGTGCTTGGATTCAGCCTCCTGCTGGGTCCTTCTGCTGGA
TACAGGCACCAAGAGGCGGTCGTGGAGCAGGGAGCTGCGCCTTCCTGGGGTGCCCGGTGGTGTGTAGAGAAAAGCTGCTTGTTTACTCCT
TAAGTCAATGTATTGGTGACTGTTGATTTGTTGAACAATTCAGGAATCAAGGGCTGTGGAGAAACTCCCTCATGTTGTTGGCAACAGGTG

>27981_27981_6_EXOSC4-NEIL2_EXOSC4_chr8_145133802_ENST00000316052_NEIL2_chr8_11637106_ENST00000455213_length(amino acids)=343AA_BP=57
MAGLELLSDQGYRVDGRRAGELRKIQARMGVFAQADGSAYIEQGNTKALAVVYGPHEVHGKKLFLRFDLDEEMGPPGSSPTPEPPQKEVQ
KEGAADPKQVGEPSGQKTLDGSSRSAELVPQGEDDSEYLERDAPAGDAGRWLRVSFGLFGSVWVNDFSRAKKANKRGDWRDPSPRLVLHF
GGGGFLAFYNCQLSWSSSPVVTPTCDILSEKFHRGQALEALGQAQPVCYTLLDQRYFSGLGNIIKNEALYRAGIHPLSLGSVLSASRREV

--------------------------------------------------------------
>27981_27981_7_EXOSC4-NEIL2_EXOSC4_chr8_145133802_ENST00000316052_NEIL2_chr8_11637107_ENST00000436750_length(transcript)=2207nt_BP=274nt
ACCTCCGGAAACCGTAGATTCCGGGCGGTCGGAGCCGCCGGGAGCTGTAGTTCTCCCGCGGCTCAGAGAAGTAGGCAGAGAGCGGACCTG
GCGGCCGGGCAGCATGGCGGGGCTGGAGCTCTTGTCGGACCAGGGCTACCGGGTGGACGGGCGGCGCGCCGGGGAGCTGCGCAAGATCCA
GGCGCGGATGGGCGTGTTCGCGCAGGCTGACGGCTCGGCCTACATTGAGCAGGGCAACACCAAGGCACTGGCTGTGGTCTACGGCCCGCA
CGAGGTCCATGGAAAGAAATTATTCCTTAGATTTGATCTAGATGAAGAAATGGGGCCCCCTGGCAGCAGCCCAACACCAGAGCCTCCACA
AAAAGAAGTGCAGAAGGAAGGGGCTGCGGACCCAAAGCAGGTCGGGGAGCCCAGCGGGCAGAAGACCCTTGATGGATCCTCACGGTCTGC
AGAGCTCGTCCCCCAGGGCGAGGATGATTCTGAGTATTTGGAGAGAGACGCCCCTGCAGGAGATGCTGGGAGGTGGCTGCGTGTCAGCTT
TGGTTTGTTTGGCAGCGTTTGGGTGAACGATTTCTCCAGAGCCAAGAAAGCCAACAAGAGGGGGGACTGGAGGGACCCTTCCCCGAGGTT
GGTCCTGCACTTTGGTGGTGGTGGCTTCCTGGCATTTTATAATTGTCAGTTGTCTTGGAGCTCTTCCCCAGTGGTCACACCCACCTGTGA
CATCCTGTCTGAGAAGTTCCATCGAGGACAAGCCTTAGAAGCTCTAGGCCAGGCTCAGCCTGTCTGCTATACACTGCTGGACCAGAGATA
CTTCTCAGGGCTAGGGAACATCATTAAGAATGAAGCCTTGTACAGAGCTGGGATCCATCCCCTTTCTCTCGGTTCAGTCCTGAGTGCCTC
GCGTCGGGAGGTCCTGGTGGATCACGTGGTGGAGTTCAGTACAGCCTGGCTGCAGGGCAAGTTCCAAGGCAGACCGCAGCACACACAGGT
CTACCAGAAAGAACAGTGCCCTGCTGGCCACCAGGTCATGAAGGAGGCGTTTGGGCCCGAAGATGGGTTACAGAGGCTCACCTGGTGGTG
CCCGCAGTGCCAGCCCCAGTTGTCAGAGGAGCCAGAGCAGTGCCAGTTCTCCTAAGGAGCTGGTGGTGCTCCTCACGGAACCTTGCCGCT
TGGGGAACCTGACGTCTAAGTGTCCAGAAAGGAGGATGTGGGCAGGGACGGGGTACAGAGGATAGTGTGGGTCAGAGGTGCCAGTAGTAT
AATATTCGTCTCCCTGGAGTTATGTTGAAGGCAGAGTTTTCATAGGGTTAGATTTTTTTTATCCTTTTCTAGTTCAGTTAATTCATCCTG
TTGAATTGCACCATCGTGAAAGATGGGAAAAATCGTGATGATGGGTAAGGGGAAAACTTCCCGGAAGGCAATGGGGCAAGGAAAAAGAAA
GCCTATGGGAAATGGCTGTGCTCCCAACATAGCTTTGCAGATGATGTGGGTTTTTTTTTTTTTTTTGGTTGTTTGTTTTGAGAGAGAGTC
TTGCTCTGTCTCCCTGGCTAGGGTGTGGTGGTGTGATCTTGGCTCACGGCAGCCTTGCCCTCCCTGGCTCAAGCAGTCTTCATCTCAGCC
TCCAGAGTAGCTGGGACTACAGGCATGTGATATGATGCTCGGCTGATTTTTGTTTACTTTTTAGAGAGATGGGGTCTTGCCATATTTGCC
AGGCTGGTTTGAACTCCTACAACTCAAGCATTCCTCCCACCTTGGTCTCCCAAAATGTTGGGACCACGGGTGTGAGCCACCGCGCCCAGC
TAGCTCCTGTGTTTTGTTTTTGTTTTGTAACTTTGGTTGATGTTAAGGCCCTCCATTTTGGAAAGCAGGAAAACAGGATTTTTTTTTTTT
TATCTTGTTCCCTGGAGGATCCAGGGATGAGGATAGAGTGGCCTGAGAGCAGTGCTTGGATTCAGCCTCCTGCTGGGTCCTTCTGCTGGA
TACAGGCACCAAGAGGCGGTCGTGGAGCAGGGAGCTGCGCCTTCCTGGGGTGCCCGGTGGTGTGTAGAGAAAAGCTGCTTGTTTACTCCT
TAAGTCAATGTATTGGTGACTGTTGATTTGTTGAACAATTCAGGAATCAAGGGCTGTGGAGAAACTCCCTCATGTTGTTGGCAACAGGTG

>27981_27981_7_EXOSC4-NEIL2_EXOSC4_chr8_145133802_ENST00000316052_NEIL2_chr8_11637107_ENST00000436750_length(amino acids)=343AA_BP=57
MAGLELLSDQGYRVDGRRAGELRKIQARMGVFAQADGSAYIEQGNTKALAVVYGPHEVHGKKLFLRFDLDEEMGPPGSSPTPEPPQKEVQ
KEGAADPKQVGEPSGQKTLDGSSRSAELVPQGEDDSEYLERDAPAGDAGRWLRVSFGLFGSVWVNDFSRAKKANKRGDWRDPSPRLVLHF
GGGGFLAFYNCQLSWSSSPVVTPTCDILSEKFHRGQALEALGQAQPVCYTLLDQRYFSGLGNIIKNEALYRAGIHPLSLGSVLSASRREV

--------------------------------------------------------------
>27981_27981_8_EXOSC4-NEIL2_EXOSC4_chr8_145133802_ENST00000316052_NEIL2_chr8_11637107_ENST00000455213_length(transcript)=2202nt_BP=274nt
ACCTCCGGAAACCGTAGATTCCGGGCGGTCGGAGCCGCCGGGAGCTGTAGTTCTCCCGCGGCTCAGAGAAGTAGGCAGAGAGCGGACCTG
GCGGCCGGGCAGCATGGCGGGGCTGGAGCTCTTGTCGGACCAGGGCTACCGGGTGGACGGGCGGCGCGCCGGGGAGCTGCGCAAGATCCA
GGCGCGGATGGGCGTGTTCGCGCAGGCTGACGGCTCGGCCTACATTGAGCAGGGCAACACCAAGGCACTGGCTGTGGTCTACGGCCCGCA
CGAGGTCCATGGAAAGAAATTATTCCTTAGATTTGATCTAGATGAAGAAATGGGGCCCCCTGGCAGCAGCCCAACACCAGAGCCTCCACA
AAAAGAAGTGCAGAAGGAAGGGGCTGCGGACCCAAAGCAGGTCGGGGAGCCCAGCGGGCAGAAGACCCTTGATGGATCCTCACGGTCTGC
AGAGCTCGTCCCCCAGGGCGAGGATGATTCTGAGTATTTGGAGAGAGACGCCCCTGCAGGAGATGCTGGGAGGTGGCTGCGTGTCAGCTT
TGGTTTGTTTGGCAGCGTTTGGGTGAACGATTTCTCCAGAGCCAAGAAAGCCAACAAGAGGGGGGACTGGAGGGACCCTTCCCCGAGGTT
GGTCCTGCACTTTGGTGGTGGTGGCTTCCTGGCATTTTATAATTGTCAGTTGTCTTGGAGCTCTTCCCCAGTGGTCACACCCACCTGTGA
CATCCTGTCTGAGAAGTTCCATCGAGGACAAGCCTTAGAAGCTCTAGGCCAGGCTCAGCCTGTCTGCTATACACTGCTGGACCAGAGATA
CTTCTCAGGGCTAGGGAACATCATTAAGAATGAAGCCTTGTACAGAGCTGGGATCCATCCCCTTTCTCTCGGTTCAGTCCTGAGTGCCTC
GCGTCGGGAGGTCCTGGTGGATCACGTGGTGGAGTTCAGTACAGCCTGGCTGCAGGGCAAGTTCCAAGGCAGACCGCAGCACACACAGGT
CTACCAGAAAGAACAGTGCCCTGCTGGCCACCAGGTCATGAAGGAGGCGTTTGGGCCCGAAGATGGGTTACAGAGGCTCACCTGGTGGTG
CCCGCAGTGCCAGCCCCAGTTGTCAGAGGAGCCAGAGCAGTGCCAGTTCTCCTAAGGAGCTGGTGGTGCTCCTCACGGAACCTTGCCGCT
TGGGGAACCTGACGTCTAAGTGTCCAGAAAGGAGGATGTGGGCAGGGACGGGGTACAGAGGATAGTGTGGGTCAGAGGTGCCAGTAGTAT
AATATTCGTCTCCCTGGAGTTATGTTGAAGGCAGAGTTTTCATAGGGTTAGATTTTTTTTATCCTTTTCTAGTTCAGTTAATTCATCCTG
TTGAATTGCACCATCGTGAAAGATGGGAAAAATCGTGATGATGGGTAAGGGGAAAACTTCCCGGAAGGCAATGGGGCAAGGAAAAAGAAA
GCCTATGGGAAATGGCTGTGCTCCCAACATAGCTTTGCAGATGATGTGGGTTTTTTTTTTTTTTTTGGTTGTTTGTTTTGAGAGAGAGTC
TTGCTCTGTCTCCCTGGCTAGGGTGTGGTGGTGTGATCTTGGCTCACGGCAGCCTTGCCCTCCCTGGCTCAAGCAGTCTTCATCTCAGCC
TCCAGAGTAGCTGGGACTACAGGCATGTGATATGATGCTCGGCTGATTTTTGTTTACTTTTTAGAGAGATGGGGTCTTGCCATATTTGCC
AGGCTGGTTTGAACTCCTACAACTCAAGCATTCCTCCCACCTTGGTCTCCCAAAATGTTGGGACCACGGGTGTGAGCCACCGCGCCCAGC
TAGCTCCTGTGTTTTGTTTTTGTTTTGTAACTTTGGTTGATGTTAAGGCCCTCCATTTTGGAAAGCAGGAAAACAGGATTTTTTTTTTTT
TATCTTGTTCCCTGGAGGATCCAGGGATGAGGATAGAGTGGCCTGAGAGCAGTGCTTGGATTCAGCCTCCTGCTGGGTCCTTCTGCTGGA
TACAGGCACCAAGAGGCGGTCGTGGAGCAGGGAGCTGCGCCTTCCTGGGGTGCCCGGTGGTGTGTAGAGAAAAGCTGCTTGTTTACTCCT
TAAGTCAATGTATTGGTGACTGTTGATTTGTTGAACAATTCAGGAATCAAGGGCTGTGGAGAAACTCCCTCATGTTGTTGGCAACAGGTG

>27981_27981_8_EXOSC4-NEIL2_EXOSC4_chr8_145133802_ENST00000316052_NEIL2_chr8_11637107_ENST00000455213_length(amino acids)=343AA_BP=57
MAGLELLSDQGYRVDGRRAGELRKIQARMGVFAQADGSAYIEQGNTKALAVVYGPHEVHGKKLFLRFDLDEEMGPPGSSPTPEPPQKEVQ
KEGAADPKQVGEPSGQKTLDGSSRSAELVPQGEDDSEYLERDAPAGDAGRWLRVSFGLFGSVWVNDFSRAKKANKRGDWRDPSPRLVLHF
GGGGFLAFYNCQLSWSSSPVVTPTCDILSEKFHRGQALEALGQAQPVCYTLLDQRYFSGLGNIIKNEALYRAGIHPLSLGSVLSASRREV

--------------------------------------------------------------
>27981_27981_9_EXOSC4-NEIL2_EXOSC4_chr8_145133802_ENST00000525936_NEIL2_chr8_11637106_ENST00000436750_length(transcript)=2185nt_BP=252nt
GGGCGGTCGGAGCCGCCGGGAGCTGTAGTTCTCCCGCGGCTCAGAGAAGTAGGCAGAGAGCGGACCTGGCGGCCGGGCAGCATGGCGGGG
CTGGAGCTCTTGTCGGACCAGGGCTACCGGGTGGACGGGCGGCGCGCCGGGGAGCTGCGCAAGATCCAGGCGCGGATGGGCGTGTTCGCG
CAGGCTGACGGCTCGGCCTACATTGAGCAGGGCAACACCAAGGCACTGGCTGTGGTCTACGGCCCGCACGAGGTCCATGGAAAGAAATTA
TTCCTTAGATTTGATCTAGATGAAGAAATGGGGCCCCCTGGCAGCAGCCCAACACCAGAGCCTCCACAAAAAGAAGTGCAGAAGGAAGGG
GCTGCGGACCCAAAGCAGGTCGGGGAGCCCAGCGGGCAGAAGACCCTTGATGGATCCTCACGGTCTGCAGAGCTCGTCCCCCAGGGCGAG
GATGATTCTGAGTATTTGGAGAGAGACGCCCCTGCAGGAGATGCTGGGAGGTGGCTGCGTGTCAGCTTTGGTTTGTTTGGCAGCGTTTGG
GTGAACGATTTCTCCAGAGCCAAGAAAGCCAACAAGAGGGGGGACTGGAGGGACCCTTCCCCGAGGTTGGTCCTGCACTTTGGTGGTGGT
GGCTTCCTGGCATTTTATAATTGTCAGTTGTCTTGGAGCTCTTCCCCAGTGGTCACACCCACCTGTGACATCCTGTCTGAGAAGTTCCAT
CGAGGACAAGCCTTAGAAGCTCTAGGCCAGGCTCAGCCTGTCTGCTATACACTGCTGGACCAGAGATACTTCTCAGGGCTAGGGAACATC
ATTAAGAATGAAGCCTTGTACAGAGCTGGGATCCATCCCCTTTCTCTCGGTTCAGTCCTGAGTGCCTCGCGTCGGGAGGTCCTGGTGGAT
CACGTGGTGGAGTTCAGTACAGCCTGGCTGCAGGGCAAGTTCCAAGGCAGACCGCAGCACACACAGGTCTACCAGAAAGAACAGTGCCCT
GCTGGCCACCAGGTCATGAAGGAGGCGTTTGGGCCCGAAGATGGGTTACAGAGGCTCACCTGGTGGTGCCCGCAGTGCCAGCCCCAGTTG
TCAGAGGAGCCAGAGCAGTGCCAGTTCTCCTAAGGAGCTGGTGGTGCTCCTCACGGAACCTTGCCGCTTGGGGAACCTGACGTCTAAGTG
TCCAGAAAGGAGGATGTGGGCAGGGACGGGGTACAGAGGATAGTGTGGGTCAGAGGTGCCAGTAGTATAATATTCGTCTCCCTGGAGTTA
TGTTGAAGGCAGAGTTTTCATAGGGTTAGATTTTTTTTATCCTTTTCTAGTTCAGTTAATTCATCCTGTTGAATTGCACCATCGTGAAAG
ATGGGAAAAATCGTGATGATGGGTAAGGGGAAAACTTCCCGGAAGGCAATGGGGCAAGGAAAAAGAAAGCCTATGGGAAATGGCTGTGCT
CCCAACATAGCTTTGCAGATGATGTGGGTTTTTTTTTTTTTTTTGGTTGTTTGTTTTGAGAGAGAGTCTTGCTCTGTCTCCCTGGCTAGG
GTGTGGTGGTGTGATCTTGGCTCACGGCAGCCTTGCCCTCCCTGGCTCAAGCAGTCTTCATCTCAGCCTCCAGAGTAGCTGGGACTACAG
GCATGTGATATGATGCTCGGCTGATTTTTGTTTACTTTTTAGAGAGATGGGGTCTTGCCATATTTGCCAGGCTGGTTTGAACTCCTACAA
CTCAAGCATTCCTCCCACCTTGGTCTCCCAAAATGTTGGGACCACGGGTGTGAGCCACCGCGCCCAGCTAGCTCCTGTGTTTTGTTTTTG
TTTTGTAACTTTGGTTGATGTTAAGGCCCTCCATTTTGGAAAGCAGGAAAACAGGATTTTTTTTTTTTTATCTTGTTCCCTGGAGGATCC
AGGGATGAGGATAGAGTGGCCTGAGAGCAGTGCTTGGATTCAGCCTCCTGCTGGGTCCTTCTGCTGGATACAGGCACCAAGAGGCGGTCG
TGGAGCAGGGAGCTGCGCCTTCCTGGGGTGCCCGGTGGTGTGTAGAGAAAAGCTGCTTGTTTACTCCTTAAGTCAATGTATTGGTGACTG
TTGATTTGTTGAACAATTCAGGAATCAAGGGCTGTGGAGAAACTCCCTCATGTTGTTGGCAACAGGTGAATGAACCTAGAGCGGTGACAT

>27981_27981_9_EXOSC4-NEIL2_EXOSC4_chr8_145133802_ENST00000525936_NEIL2_chr8_11637106_ENST00000436750_length(amino acids)=343AA_BP=57
MAGLELLSDQGYRVDGRRAGELRKIQARMGVFAQADGSAYIEQGNTKALAVVYGPHEVHGKKLFLRFDLDEEMGPPGSSPTPEPPQKEVQ
KEGAADPKQVGEPSGQKTLDGSSRSAELVPQGEDDSEYLERDAPAGDAGRWLRVSFGLFGSVWVNDFSRAKKANKRGDWRDPSPRLVLHF
GGGGFLAFYNCQLSWSSSPVVTPTCDILSEKFHRGQALEALGQAQPVCYTLLDQRYFSGLGNIIKNEALYRAGIHPLSLGSVLSASRREV

--------------------------------------------------------------
>27981_27981_10_EXOSC4-NEIL2_EXOSC4_chr8_145133802_ENST00000525936_NEIL2_chr8_11637106_ENST00000455213_length(transcript)=2180nt_BP=252nt
GGGCGGTCGGAGCCGCCGGGAGCTGTAGTTCTCCCGCGGCTCAGAGAAGTAGGCAGAGAGCGGACCTGGCGGCCGGGCAGCATGGCGGGG
CTGGAGCTCTTGTCGGACCAGGGCTACCGGGTGGACGGGCGGCGCGCCGGGGAGCTGCGCAAGATCCAGGCGCGGATGGGCGTGTTCGCG
CAGGCTGACGGCTCGGCCTACATTGAGCAGGGCAACACCAAGGCACTGGCTGTGGTCTACGGCCCGCACGAGGTCCATGGAAAGAAATTA
TTCCTTAGATTTGATCTAGATGAAGAAATGGGGCCCCCTGGCAGCAGCCCAACACCAGAGCCTCCACAAAAAGAAGTGCAGAAGGAAGGG
GCTGCGGACCCAAAGCAGGTCGGGGAGCCCAGCGGGCAGAAGACCCTTGATGGATCCTCACGGTCTGCAGAGCTCGTCCCCCAGGGCGAG
GATGATTCTGAGTATTTGGAGAGAGACGCCCCTGCAGGAGATGCTGGGAGGTGGCTGCGTGTCAGCTTTGGTTTGTTTGGCAGCGTTTGG
GTGAACGATTTCTCCAGAGCCAAGAAAGCCAACAAGAGGGGGGACTGGAGGGACCCTTCCCCGAGGTTGGTCCTGCACTTTGGTGGTGGT
GGCTTCCTGGCATTTTATAATTGTCAGTTGTCTTGGAGCTCTTCCCCAGTGGTCACACCCACCTGTGACATCCTGTCTGAGAAGTTCCAT
CGAGGACAAGCCTTAGAAGCTCTAGGCCAGGCTCAGCCTGTCTGCTATACACTGCTGGACCAGAGATACTTCTCAGGGCTAGGGAACATC
ATTAAGAATGAAGCCTTGTACAGAGCTGGGATCCATCCCCTTTCTCTCGGTTCAGTCCTGAGTGCCTCGCGTCGGGAGGTCCTGGTGGAT
CACGTGGTGGAGTTCAGTACAGCCTGGCTGCAGGGCAAGTTCCAAGGCAGACCGCAGCACACACAGGTCTACCAGAAAGAACAGTGCCCT
GCTGGCCACCAGGTCATGAAGGAGGCGTTTGGGCCCGAAGATGGGTTACAGAGGCTCACCTGGTGGTGCCCGCAGTGCCAGCCCCAGTTG
TCAGAGGAGCCAGAGCAGTGCCAGTTCTCCTAAGGAGCTGGTGGTGCTCCTCACGGAACCTTGCCGCTTGGGGAACCTGACGTCTAAGTG
TCCAGAAAGGAGGATGTGGGCAGGGACGGGGTACAGAGGATAGTGTGGGTCAGAGGTGCCAGTAGTATAATATTCGTCTCCCTGGAGTTA
TGTTGAAGGCAGAGTTTTCATAGGGTTAGATTTTTTTTATCCTTTTCTAGTTCAGTTAATTCATCCTGTTGAATTGCACCATCGTGAAAG
ATGGGAAAAATCGTGATGATGGGTAAGGGGAAAACTTCCCGGAAGGCAATGGGGCAAGGAAAAAGAAAGCCTATGGGAAATGGCTGTGCT
CCCAACATAGCTTTGCAGATGATGTGGGTTTTTTTTTTTTTTTTGGTTGTTTGTTTTGAGAGAGAGTCTTGCTCTGTCTCCCTGGCTAGG
GTGTGGTGGTGTGATCTTGGCTCACGGCAGCCTTGCCCTCCCTGGCTCAAGCAGTCTTCATCTCAGCCTCCAGAGTAGCTGGGACTACAG
GCATGTGATATGATGCTCGGCTGATTTTTGTTTACTTTTTAGAGAGATGGGGTCTTGCCATATTTGCCAGGCTGGTTTGAACTCCTACAA
CTCAAGCATTCCTCCCACCTTGGTCTCCCAAAATGTTGGGACCACGGGTGTGAGCCACCGCGCCCAGCTAGCTCCTGTGTTTTGTTTTTG
TTTTGTAACTTTGGTTGATGTTAAGGCCCTCCATTTTGGAAAGCAGGAAAACAGGATTTTTTTTTTTTTATCTTGTTCCCTGGAGGATCC
AGGGATGAGGATAGAGTGGCCTGAGAGCAGTGCTTGGATTCAGCCTCCTGCTGGGTCCTTCTGCTGGATACAGGCACCAAGAGGCGGTCG
TGGAGCAGGGAGCTGCGCCTTCCTGGGGTGCCCGGTGGTGTGTAGAGAAAAGCTGCTTGTTTACTCCTTAAGTCAATGTATTGGTGACTG
TTGATTTGTTGAACAATTCAGGAATCAAGGGCTGTGGAGAAACTCCCTCATGTTGTTGGCAACAGGTGAATGAACCTAGAGCGGTGACAT

>27981_27981_10_EXOSC4-NEIL2_EXOSC4_chr8_145133802_ENST00000525936_NEIL2_chr8_11637106_ENST00000455213_length(amino acids)=343AA_BP=57
MAGLELLSDQGYRVDGRRAGELRKIQARMGVFAQADGSAYIEQGNTKALAVVYGPHEVHGKKLFLRFDLDEEMGPPGSSPTPEPPQKEVQ
KEGAADPKQVGEPSGQKTLDGSSRSAELVPQGEDDSEYLERDAPAGDAGRWLRVSFGLFGSVWVNDFSRAKKANKRGDWRDPSPRLVLHF
GGGGFLAFYNCQLSWSSSPVVTPTCDILSEKFHRGQALEALGQAQPVCYTLLDQRYFSGLGNIIKNEALYRAGIHPLSLGSVLSASRREV

--------------------------------------------------------------
>27981_27981_11_EXOSC4-NEIL2_EXOSC4_chr8_145133802_ENST00000525936_NEIL2_chr8_11637107_ENST00000436750_length(transcript)=2185nt_BP=252nt
GGGCGGTCGGAGCCGCCGGGAGCTGTAGTTCTCCCGCGGCTCAGAGAAGTAGGCAGAGAGCGGACCTGGCGGCCGGGCAGCATGGCGGGG
CTGGAGCTCTTGTCGGACCAGGGCTACCGGGTGGACGGGCGGCGCGCCGGGGAGCTGCGCAAGATCCAGGCGCGGATGGGCGTGTTCGCG
CAGGCTGACGGCTCGGCCTACATTGAGCAGGGCAACACCAAGGCACTGGCTGTGGTCTACGGCCCGCACGAGGTCCATGGAAAGAAATTA
TTCCTTAGATTTGATCTAGATGAAGAAATGGGGCCCCCTGGCAGCAGCCCAACACCAGAGCCTCCACAAAAAGAAGTGCAGAAGGAAGGG
GCTGCGGACCCAAAGCAGGTCGGGGAGCCCAGCGGGCAGAAGACCCTTGATGGATCCTCACGGTCTGCAGAGCTCGTCCCCCAGGGCGAG
GATGATTCTGAGTATTTGGAGAGAGACGCCCCTGCAGGAGATGCTGGGAGGTGGCTGCGTGTCAGCTTTGGTTTGTTTGGCAGCGTTTGG
GTGAACGATTTCTCCAGAGCCAAGAAAGCCAACAAGAGGGGGGACTGGAGGGACCCTTCCCCGAGGTTGGTCCTGCACTTTGGTGGTGGT
GGCTTCCTGGCATTTTATAATTGTCAGTTGTCTTGGAGCTCTTCCCCAGTGGTCACACCCACCTGTGACATCCTGTCTGAGAAGTTCCAT
CGAGGACAAGCCTTAGAAGCTCTAGGCCAGGCTCAGCCTGTCTGCTATACACTGCTGGACCAGAGATACTTCTCAGGGCTAGGGAACATC
ATTAAGAATGAAGCCTTGTACAGAGCTGGGATCCATCCCCTTTCTCTCGGTTCAGTCCTGAGTGCCTCGCGTCGGGAGGTCCTGGTGGAT
CACGTGGTGGAGTTCAGTACAGCCTGGCTGCAGGGCAAGTTCCAAGGCAGACCGCAGCACACACAGGTCTACCAGAAAGAACAGTGCCCT
GCTGGCCACCAGGTCATGAAGGAGGCGTTTGGGCCCGAAGATGGGTTACAGAGGCTCACCTGGTGGTGCCCGCAGTGCCAGCCCCAGTTG
TCAGAGGAGCCAGAGCAGTGCCAGTTCTCCTAAGGAGCTGGTGGTGCTCCTCACGGAACCTTGCCGCTTGGGGAACCTGACGTCTAAGTG
TCCAGAAAGGAGGATGTGGGCAGGGACGGGGTACAGAGGATAGTGTGGGTCAGAGGTGCCAGTAGTATAATATTCGTCTCCCTGGAGTTA
TGTTGAAGGCAGAGTTTTCATAGGGTTAGATTTTTTTTATCCTTTTCTAGTTCAGTTAATTCATCCTGTTGAATTGCACCATCGTGAAAG
ATGGGAAAAATCGTGATGATGGGTAAGGGGAAAACTTCCCGGAAGGCAATGGGGCAAGGAAAAAGAAAGCCTATGGGAAATGGCTGTGCT
CCCAACATAGCTTTGCAGATGATGTGGGTTTTTTTTTTTTTTTTGGTTGTTTGTTTTGAGAGAGAGTCTTGCTCTGTCTCCCTGGCTAGG
GTGTGGTGGTGTGATCTTGGCTCACGGCAGCCTTGCCCTCCCTGGCTCAAGCAGTCTTCATCTCAGCCTCCAGAGTAGCTGGGACTACAG
GCATGTGATATGATGCTCGGCTGATTTTTGTTTACTTTTTAGAGAGATGGGGTCTTGCCATATTTGCCAGGCTGGTTTGAACTCCTACAA
CTCAAGCATTCCTCCCACCTTGGTCTCCCAAAATGTTGGGACCACGGGTGTGAGCCACCGCGCCCAGCTAGCTCCTGTGTTTTGTTTTTG
TTTTGTAACTTTGGTTGATGTTAAGGCCCTCCATTTTGGAAAGCAGGAAAACAGGATTTTTTTTTTTTTATCTTGTTCCCTGGAGGATCC
AGGGATGAGGATAGAGTGGCCTGAGAGCAGTGCTTGGATTCAGCCTCCTGCTGGGTCCTTCTGCTGGATACAGGCACCAAGAGGCGGTCG
TGGAGCAGGGAGCTGCGCCTTCCTGGGGTGCCCGGTGGTGTGTAGAGAAAAGCTGCTTGTTTACTCCTTAAGTCAATGTATTGGTGACTG
TTGATTTGTTGAACAATTCAGGAATCAAGGGCTGTGGAGAAACTCCCTCATGTTGTTGGCAACAGGTGAATGAACCTAGAGCGGTGACAT

>27981_27981_11_EXOSC4-NEIL2_EXOSC4_chr8_145133802_ENST00000525936_NEIL2_chr8_11637107_ENST00000436750_length(amino acids)=343AA_BP=57
MAGLELLSDQGYRVDGRRAGELRKIQARMGVFAQADGSAYIEQGNTKALAVVYGPHEVHGKKLFLRFDLDEEMGPPGSSPTPEPPQKEVQ
KEGAADPKQVGEPSGQKTLDGSSRSAELVPQGEDDSEYLERDAPAGDAGRWLRVSFGLFGSVWVNDFSRAKKANKRGDWRDPSPRLVLHF
GGGGFLAFYNCQLSWSSSPVVTPTCDILSEKFHRGQALEALGQAQPVCYTLLDQRYFSGLGNIIKNEALYRAGIHPLSLGSVLSASRREV

--------------------------------------------------------------
>27981_27981_12_EXOSC4-NEIL2_EXOSC4_chr8_145133802_ENST00000525936_NEIL2_chr8_11637107_ENST00000455213_length(transcript)=2180nt_BP=252nt
GGGCGGTCGGAGCCGCCGGGAGCTGTAGTTCTCCCGCGGCTCAGAGAAGTAGGCAGAGAGCGGACCTGGCGGCCGGGCAGCATGGCGGGG
CTGGAGCTCTTGTCGGACCAGGGCTACCGGGTGGACGGGCGGCGCGCCGGGGAGCTGCGCAAGATCCAGGCGCGGATGGGCGTGTTCGCG
CAGGCTGACGGCTCGGCCTACATTGAGCAGGGCAACACCAAGGCACTGGCTGTGGTCTACGGCCCGCACGAGGTCCATGGAAAGAAATTA
TTCCTTAGATTTGATCTAGATGAAGAAATGGGGCCCCCTGGCAGCAGCCCAACACCAGAGCCTCCACAAAAAGAAGTGCAGAAGGAAGGG
GCTGCGGACCCAAAGCAGGTCGGGGAGCCCAGCGGGCAGAAGACCCTTGATGGATCCTCACGGTCTGCAGAGCTCGTCCCCCAGGGCGAG
GATGATTCTGAGTATTTGGAGAGAGACGCCCCTGCAGGAGATGCTGGGAGGTGGCTGCGTGTCAGCTTTGGTTTGTTTGGCAGCGTTTGG
GTGAACGATTTCTCCAGAGCCAAGAAAGCCAACAAGAGGGGGGACTGGAGGGACCCTTCCCCGAGGTTGGTCCTGCACTTTGGTGGTGGT
GGCTTCCTGGCATTTTATAATTGTCAGTTGTCTTGGAGCTCTTCCCCAGTGGTCACACCCACCTGTGACATCCTGTCTGAGAAGTTCCAT
CGAGGACAAGCCTTAGAAGCTCTAGGCCAGGCTCAGCCTGTCTGCTATACACTGCTGGACCAGAGATACTTCTCAGGGCTAGGGAACATC
ATTAAGAATGAAGCCTTGTACAGAGCTGGGATCCATCCCCTTTCTCTCGGTTCAGTCCTGAGTGCCTCGCGTCGGGAGGTCCTGGTGGAT
CACGTGGTGGAGTTCAGTACAGCCTGGCTGCAGGGCAAGTTCCAAGGCAGACCGCAGCACACACAGGTCTACCAGAAAGAACAGTGCCCT
GCTGGCCACCAGGTCATGAAGGAGGCGTTTGGGCCCGAAGATGGGTTACAGAGGCTCACCTGGTGGTGCCCGCAGTGCCAGCCCCAGTTG
TCAGAGGAGCCAGAGCAGTGCCAGTTCTCCTAAGGAGCTGGTGGTGCTCCTCACGGAACCTTGCCGCTTGGGGAACCTGACGTCTAAGTG
TCCAGAAAGGAGGATGTGGGCAGGGACGGGGTACAGAGGATAGTGTGGGTCAGAGGTGCCAGTAGTATAATATTCGTCTCCCTGGAGTTA
TGTTGAAGGCAGAGTTTTCATAGGGTTAGATTTTTTTTATCCTTTTCTAGTTCAGTTAATTCATCCTGTTGAATTGCACCATCGTGAAAG
ATGGGAAAAATCGTGATGATGGGTAAGGGGAAAACTTCCCGGAAGGCAATGGGGCAAGGAAAAAGAAAGCCTATGGGAAATGGCTGTGCT
CCCAACATAGCTTTGCAGATGATGTGGGTTTTTTTTTTTTTTTTGGTTGTTTGTTTTGAGAGAGAGTCTTGCTCTGTCTCCCTGGCTAGG
GTGTGGTGGTGTGATCTTGGCTCACGGCAGCCTTGCCCTCCCTGGCTCAAGCAGTCTTCATCTCAGCCTCCAGAGTAGCTGGGACTACAG
GCATGTGATATGATGCTCGGCTGATTTTTGTTTACTTTTTAGAGAGATGGGGTCTTGCCATATTTGCCAGGCTGGTTTGAACTCCTACAA
CTCAAGCATTCCTCCCACCTTGGTCTCCCAAAATGTTGGGACCACGGGTGTGAGCCACCGCGCCCAGCTAGCTCCTGTGTTTTGTTTTTG
TTTTGTAACTTTGGTTGATGTTAAGGCCCTCCATTTTGGAAAGCAGGAAAACAGGATTTTTTTTTTTTTATCTTGTTCCCTGGAGGATCC
AGGGATGAGGATAGAGTGGCCTGAGAGCAGTGCTTGGATTCAGCCTCCTGCTGGGTCCTTCTGCTGGATACAGGCACCAAGAGGCGGTCG
TGGAGCAGGGAGCTGCGCCTTCCTGGGGTGCCCGGTGGTGTGTAGAGAAAAGCTGCTTGTTTACTCCTTAAGTCAATGTATTGGTGACTG
TTGATTTGTTGAACAATTCAGGAATCAAGGGCTGTGGAGAAACTCCCTCATGTTGTTGGCAACAGGTGAATGAACCTAGAGCGGTGACAT

>27981_27981_12_EXOSC4-NEIL2_EXOSC4_chr8_145133802_ENST00000525936_NEIL2_chr8_11637107_ENST00000455213_length(amino acids)=343AA_BP=57
MAGLELLSDQGYRVDGRRAGELRKIQARMGVFAQADGSAYIEQGNTKALAVVYGPHEVHGKKLFLRFDLDEEMGPPGSSPTPEPPQKEVQ
KEGAADPKQVGEPSGQKTLDGSSRSAELVPQGEDDSEYLERDAPAGDAGRWLRVSFGLFGSVWVNDFSRAKKANKRGDWRDPSPRLVLHF
GGGGFLAFYNCQLSWSSSPVVTPTCDILSEKFHRGQALEALGQAQPVCYTLLDQRYFSGLGNIIKNEALYRAGIHPLSLGSVLSASRREV

--------------------------------------------------------------
>27981_27981_13_EXOSC4-NEIL2_EXOSC4_chr8_145133803_ENST00000316052_NEIL2_chr8_11637108_ENST00000436750_length(transcript)=2207nt_BP=274nt
ACCTCCGGAAACCGTAGATTCCGGGCGGTCGGAGCCGCCGGGAGCTGTAGTTCTCCCGCGGCTCAGAGAAGTAGGCAGAGAGCGGACCTG
GCGGCCGGGCAGCATGGCGGGGCTGGAGCTCTTGTCGGACCAGGGCTACCGGGTGGACGGGCGGCGCGCCGGGGAGCTGCGCAAGATCCA
GGCGCGGATGGGCGTGTTCGCGCAGGCTGACGGCTCGGCCTACATTGAGCAGGGCAACACCAAGGCACTGGCTGTGGTCTACGGCCCGCA
CGAGGTCCATGGAAAGAAATTATTCCTTAGATTTGATCTAGATGAAGAAATGGGGCCCCCTGGCAGCAGCCCAACACCAGAGCCTCCACA
AAAAGAAGTGCAGAAGGAAGGGGCTGCGGACCCAAAGCAGGTCGGGGAGCCCAGCGGGCAGAAGACCCTTGATGGATCCTCACGGTCTGC
AGAGCTCGTCCCCCAGGGCGAGGATGATTCTGAGTATTTGGAGAGAGACGCCCCTGCAGGAGATGCTGGGAGGTGGCTGCGTGTCAGCTT
TGGTTTGTTTGGCAGCGTTTGGGTGAACGATTTCTCCAGAGCCAAGAAAGCCAACAAGAGGGGGGACTGGAGGGACCCTTCCCCGAGGTT
GGTCCTGCACTTTGGTGGTGGTGGCTTCCTGGCATTTTATAATTGTCAGTTGTCTTGGAGCTCTTCCCCAGTGGTCACACCCACCTGTGA
CATCCTGTCTGAGAAGTTCCATCGAGGACAAGCCTTAGAAGCTCTAGGCCAGGCTCAGCCTGTCTGCTATACACTGCTGGACCAGAGATA
CTTCTCAGGGCTAGGGAACATCATTAAGAATGAAGCCTTGTACAGAGCTGGGATCCATCCCCTTTCTCTCGGTTCAGTCCTGAGTGCCTC
GCGTCGGGAGGTCCTGGTGGATCACGTGGTGGAGTTCAGTACAGCCTGGCTGCAGGGCAAGTTCCAAGGCAGACCGCAGCACACACAGGT
CTACCAGAAAGAACAGTGCCCTGCTGGCCACCAGGTCATGAAGGAGGCGTTTGGGCCCGAAGATGGGTTACAGAGGCTCACCTGGTGGTG
CCCGCAGTGCCAGCCCCAGTTGTCAGAGGAGCCAGAGCAGTGCCAGTTCTCCTAAGGAGCTGGTGGTGCTCCTCACGGAACCTTGCCGCT
TGGGGAACCTGACGTCTAAGTGTCCAGAAAGGAGGATGTGGGCAGGGACGGGGTACAGAGGATAGTGTGGGTCAGAGGTGCCAGTAGTAT
AATATTCGTCTCCCTGGAGTTATGTTGAAGGCAGAGTTTTCATAGGGTTAGATTTTTTTTATCCTTTTCTAGTTCAGTTAATTCATCCTG
TTGAATTGCACCATCGTGAAAGATGGGAAAAATCGTGATGATGGGTAAGGGGAAAACTTCCCGGAAGGCAATGGGGCAAGGAAAAAGAAA
GCCTATGGGAAATGGCTGTGCTCCCAACATAGCTTTGCAGATGATGTGGGTTTTTTTTTTTTTTTTGGTTGTTTGTTTTGAGAGAGAGTC
TTGCTCTGTCTCCCTGGCTAGGGTGTGGTGGTGTGATCTTGGCTCACGGCAGCCTTGCCCTCCCTGGCTCAAGCAGTCTTCATCTCAGCC
TCCAGAGTAGCTGGGACTACAGGCATGTGATATGATGCTCGGCTGATTTTTGTTTACTTTTTAGAGAGATGGGGTCTTGCCATATTTGCC
AGGCTGGTTTGAACTCCTACAACTCAAGCATTCCTCCCACCTTGGTCTCCCAAAATGTTGGGACCACGGGTGTGAGCCACCGCGCCCAGC
TAGCTCCTGTGTTTTGTTTTTGTTTTGTAACTTTGGTTGATGTTAAGGCCCTCCATTTTGGAAAGCAGGAAAACAGGATTTTTTTTTTTT
TATCTTGTTCCCTGGAGGATCCAGGGATGAGGATAGAGTGGCCTGAGAGCAGTGCTTGGATTCAGCCTCCTGCTGGGTCCTTCTGCTGGA
TACAGGCACCAAGAGGCGGTCGTGGAGCAGGGAGCTGCGCCTTCCTGGGGTGCCCGGTGGTGTGTAGAGAAAAGCTGCTTGTTTACTCCT
TAAGTCAATGTATTGGTGACTGTTGATTTGTTGAACAATTCAGGAATCAAGGGCTGTGGAGAAACTCCCTCATGTTGTTGGCAACAGGTG

>27981_27981_13_EXOSC4-NEIL2_EXOSC4_chr8_145133803_ENST00000316052_NEIL2_chr8_11637108_ENST00000436750_length(amino acids)=343AA_BP=57
MAGLELLSDQGYRVDGRRAGELRKIQARMGVFAQADGSAYIEQGNTKALAVVYGPHEVHGKKLFLRFDLDEEMGPPGSSPTPEPPQKEVQ
KEGAADPKQVGEPSGQKTLDGSSRSAELVPQGEDDSEYLERDAPAGDAGRWLRVSFGLFGSVWVNDFSRAKKANKRGDWRDPSPRLVLHF
GGGGFLAFYNCQLSWSSSPVVTPTCDILSEKFHRGQALEALGQAQPVCYTLLDQRYFSGLGNIIKNEALYRAGIHPLSLGSVLSASRREV

--------------------------------------------------------------
>27981_27981_14_EXOSC4-NEIL2_EXOSC4_chr8_145133803_ENST00000316052_NEIL2_chr8_11637108_ENST00000455213_length(transcript)=2202nt_BP=274nt
ACCTCCGGAAACCGTAGATTCCGGGCGGTCGGAGCCGCCGGGAGCTGTAGTTCTCCCGCGGCTCAGAGAAGTAGGCAGAGAGCGGACCTG
GCGGCCGGGCAGCATGGCGGGGCTGGAGCTCTTGTCGGACCAGGGCTACCGGGTGGACGGGCGGCGCGCCGGGGAGCTGCGCAAGATCCA
GGCGCGGATGGGCGTGTTCGCGCAGGCTGACGGCTCGGCCTACATTGAGCAGGGCAACACCAAGGCACTGGCTGTGGTCTACGGCCCGCA
CGAGGTCCATGGAAAGAAATTATTCCTTAGATTTGATCTAGATGAAGAAATGGGGCCCCCTGGCAGCAGCCCAACACCAGAGCCTCCACA
AAAAGAAGTGCAGAAGGAAGGGGCTGCGGACCCAAAGCAGGTCGGGGAGCCCAGCGGGCAGAAGACCCTTGATGGATCCTCACGGTCTGC
AGAGCTCGTCCCCCAGGGCGAGGATGATTCTGAGTATTTGGAGAGAGACGCCCCTGCAGGAGATGCTGGGAGGTGGCTGCGTGTCAGCTT
TGGTTTGTTTGGCAGCGTTTGGGTGAACGATTTCTCCAGAGCCAAGAAAGCCAACAAGAGGGGGGACTGGAGGGACCCTTCCCCGAGGTT
GGTCCTGCACTTTGGTGGTGGTGGCTTCCTGGCATTTTATAATTGTCAGTTGTCTTGGAGCTCTTCCCCAGTGGTCACACCCACCTGTGA
CATCCTGTCTGAGAAGTTCCATCGAGGACAAGCCTTAGAAGCTCTAGGCCAGGCTCAGCCTGTCTGCTATACACTGCTGGACCAGAGATA
CTTCTCAGGGCTAGGGAACATCATTAAGAATGAAGCCTTGTACAGAGCTGGGATCCATCCCCTTTCTCTCGGTTCAGTCCTGAGTGCCTC
GCGTCGGGAGGTCCTGGTGGATCACGTGGTGGAGTTCAGTACAGCCTGGCTGCAGGGCAAGTTCCAAGGCAGACCGCAGCACACACAGGT
CTACCAGAAAGAACAGTGCCCTGCTGGCCACCAGGTCATGAAGGAGGCGTTTGGGCCCGAAGATGGGTTACAGAGGCTCACCTGGTGGTG
CCCGCAGTGCCAGCCCCAGTTGTCAGAGGAGCCAGAGCAGTGCCAGTTCTCCTAAGGAGCTGGTGGTGCTCCTCACGGAACCTTGCCGCT
TGGGGAACCTGACGTCTAAGTGTCCAGAAAGGAGGATGTGGGCAGGGACGGGGTACAGAGGATAGTGTGGGTCAGAGGTGCCAGTAGTAT
AATATTCGTCTCCCTGGAGTTATGTTGAAGGCAGAGTTTTCATAGGGTTAGATTTTTTTTATCCTTTTCTAGTTCAGTTAATTCATCCTG
TTGAATTGCACCATCGTGAAAGATGGGAAAAATCGTGATGATGGGTAAGGGGAAAACTTCCCGGAAGGCAATGGGGCAAGGAAAAAGAAA
GCCTATGGGAAATGGCTGTGCTCCCAACATAGCTTTGCAGATGATGTGGGTTTTTTTTTTTTTTTTGGTTGTTTGTTTTGAGAGAGAGTC
TTGCTCTGTCTCCCTGGCTAGGGTGTGGTGGTGTGATCTTGGCTCACGGCAGCCTTGCCCTCCCTGGCTCAAGCAGTCTTCATCTCAGCC
TCCAGAGTAGCTGGGACTACAGGCATGTGATATGATGCTCGGCTGATTTTTGTTTACTTTTTAGAGAGATGGGGTCTTGCCATATTTGCC
AGGCTGGTTTGAACTCCTACAACTCAAGCATTCCTCCCACCTTGGTCTCCCAAAATGTTGGGACCACGGGTGTGAGCCACCGCGCCCAGC
TAGCTCCTGTGTTTTGTTTTTGTTTTGTAACTTTGGTTGATGTTAAGGCCCTCCATTTTGGAAAGCAGGAAAACAGGATTTTTTTTTTTT
TATCTTGTTCCCTGGAGGATCCAGGGATGAGGATAGAGTGGCCTGAGAGCAGTGCTTGGATTCAGCCTCCTGCTGGGTCCTTCTGCTGGA
TACAGGCACCAAGAGGCGGTCGTGGAGCAGGGAGCTGCGCCTTCCTGGGGTGCCCGGTGGTGTGTAGAGAAAAGCTGCTTGTTTACTCCT
TAAGTCAATGTATTGGTGACTGTTGATTTGTTGAACAATTCAGGAATCAAGGGCTGTGGAGAAACTCCCTCATGTTGTTGGCAACAGGTG

>27981_27981_14_EXOSC4-NEIL2_EXOSC4_chr8_145133803_ENST00000316052_NEIL2_chr8_11637108_ENST00000455213_length(amino acids)=343AA_BP=57
MAGLELLSDQGYRVDGRRAGELRKIQARMGVFAQADGSAYIEQGNTKALAVVYGPHEVHGKKLFLRFDLDEEMGPPGSSPTPEPPQKEVQ
KEGAADPKQVGEPSGQKTLDGSSRSAELVPQGEDDSEYLERDAPAGDAGRWLRVSFGLFGSVWVNDFSRAKKANKRGDWRDPSPRLVLHF
GGGGFLAFYNCQLSWSSSPVVTPTCDILSEKFHRGQALEALGQAQPVCYTLLDQRYFSGLGNIIKNEALYRAGIHPLSLGSVLSASRREV

--------------------------------------------------------------
>27981_27981_15_EXOSC4-NEIL2_EXOSC4_chr8_145133803_ENST00000525936_NEIL2_chr8_11637108_ENST00000436750_length(transcript)=2185nt_BP=252nt
GGGCGGTCGGAGCCGCCGGGAGCTGTAGTTCTCCCGCGGCTCAGAGAAGTAGGCAGAGAGCGGACCTGGCGGCCGGGCAGCATGGCGGGG
CTGGAGCTCTTGTCGGACCAGGGCTACCGGGTGGACGGGCGGCGCGCCGGGGAGCTGCGCAAGATCCAGGCGCGGATGGGCGTGTTCGCG
CAGGCTGACGGCTCGGCCTACATTGAGCAGGGCAACACCAAGGCACTGGCTGTGGTCTACGGCCCGCACGAGGTCCATGGAAAGAAATTA
TTCCTTAGATTTGATCTAGATGAAGAAATGGGGCCCCCTGGCAGCAGCCCAACACCAGAGCCTCCACAAAAAGAAGTGCAGAAGGAAGGG
GCTGCGGACCCAAAGCAGGTCGGGGAGCCCAGCGGGCAGAAGACCCTTGATGGATCCTCACGGTCTGCAGAGCTCGTCCCCCAGGGCGAG
GATGATTCTGAGTATTTGGAGAGAGACGCCCCTGCAGGAGATGCTGGGAGGTGGCTGCGTGTCAGCTTTGGTTTGTTTGGCAGCGTTTGG
GTGAACGATTTCTCCAGAGCCAAGAAAGCCAACAAGAGGGGGGACTGGAGGGACCCTTCCCCGAGGTTGGTCCTGCACTTTGGTGGTGGT
GGCTTCCTGGCATTTTATAATTGTCAGTTGTCTTGGAGCTCTTCCCCAGTGGTCACACCCACCTGTGACATCCTGTCTGAGAAGTTCCAT
CGAGGACAAGCCTTAGAAGCTCTAGGCCAGGCTCAGCCTGTCTGCTATACACTGCTGGACCAGAGATACTTCTCAGGGCTAGGGAACATC
ATTAAGAATGAAGCCTTGTACAGAGCTGGGATCCATCCCCTTTCTCTCGGTTCAGTCCTGAGTGCCTCGCGTCGGGAGGTCCTGGTGGAT
CACGTGGTGGAGTTCAGTACAGCCTGGCTGCAGGGCAAGTTCCAAGGCAGACCGCAGCACACACAGGTCTACCAGAAAGAACAGTGCCCT
GCTGGCCACCAGGTCATGAAGGAGGCGTTTGGGCCCGAAGATGGGTTACAGAGGCTCACCTGGTGGTGCCCGCAGTGCCAGCCCCAGTTG
TCAGAGGAGCCAGAGCAGTGCCAGTTCTCCTAAGGAGCTGGTGGTGCTCCTCACGGAACCTTGCCGCTTGGGGAACCTGACGTCTAAGTG
TCCAGAAAGGAGGATGTGGGCAGGGACGGGGTACAGAGGATAGTGTGGGTCAGAGGTGCCAGTAGTATAATATTCGTCTCCCTGGAGTTA
TGTTGAAGGCAGAGTTTTCATAGGGTTAGATTTTTTTTATCCTTTTCTAGTTCAGTTAATTCATCCTGTTGAATTGCACCATCGTGAAAG
ATGGGAAAAATCGTGATGATGGGTAAGGGGAAAACTTCCCGGAAGGCAATGGGGCAAGGAAAAAGAAAGCCTATGGGAAATGGCTGTGCT
CCCAACATAGCTTTGCAGATGATGTGGGTTTTTTTTTTTTTTTTGGTTGTTTGTTTTGAGAGAGAGTCTTGCTCTGTCTCCCTGGCTAGG
GTGTGGTGGTGTGATCTTGGCTCACGGCAGCCTTGCCCTCCCTGGCTCAAGCAGTCTTCATCTCAGCCTCCAGAGTAGCTGGGACTACAG
GCATGTGATATGATGCTCGGCTGATTTTTGTTTACTTTTTAGAGAGATGGGGTCTTGCCATATTTGCCAGGCTGGTTTGAACTCCTACAA
CTCAAGCATTCCTCCCACCTTGGTCTCCCAAAATGTTGGGACCACGGGTGTGAGCCACCGCGCCCAGCTAGCTCCTGTGTTTTGTTTTTG
TTTTGTAACTTTGGTTGATGTTAAGGCCCTCCATTTTGGAAAGCAGGAAAACAGGATTTTTTTTTTTTTATCTTGTTCCCTGGAGGATCC
AGGGATGAGGATAGAGTGGCCTGAGAGCAGTGCTTGGATTCAGCCTCCTGCTGGGTCCTTCTGCTGGATACAGGCACCAAGAGGCGGTCG
TGGAGCAGGGAGCTGCGCCTTCCTGGGGTGCCCGGTGGTGTGTAGAGAAAAGCTGCTTGTTTACTCCTTAAGTCAATGTATTGGTGACTG
TTGATTTGTTGAACAATTCAGGAATCAAGGGCTGTGGAGAAACTCCCTCATGTTGTTGGCAACAGGTGAATGAACCTAGAGCGGTGACAT

>27981_27981_15_EXOSC4-NEIL2_EXOSC4_chr8_145133803_ENST00000525936_NEIL2_chr8_11637108_ENST00000436750_length(amino acids)=343AA_BP=57
MAGLELLSDQGYRVDGRRAGELRKIQARMGVFAQADGSAYIEQGNTKALAVVYGPHEVHGKKLFLRFDLDEEMGPPGSSPTPEPPQKEVQ
KEGAADPKQVGEPSGQKTLDGSSRSAELVPQGEDDSEYLERDAPAGDAGRWLRVSFGLFGSVWVNDFSRAKKANKRGDWRDPSPRLVLHF
GGGGFLAFYNCQLSWSSSPVVTPTCDILSEKFHRGQALEALGQAQPVCYTLLDQRYFSGLGNIIKNEALYRAGIHPLSLGSVLSASRREV

--------------------------------------------------------------
>27981_27981_16_EXOSC4-NEIL2_EXOSC4_chr8_145133803_ENST00000525936_NEIL2_chr8_11637108_ENST00000455213_length(transcript)=2180nt_BP=252nt
GGGCGGTCGGAGCCGCCGGGAGCTGTAGTTCTCCCGCGGCTCAGAGAAGTAGGCAGAGAGCGGACCTGGCGGCCGGGCAGCATGGCGGGG
CTGGAGCTCTTGTCGGACCAGGGCTACCGGGTGGACGGGCGGCGCGCCGGGGAGCTGCGCAAGATCCAGGCGCGGATGGGCGTGTTCGCG
CAGGCTGACGGCTCGGCCTACATTGAGCAGGGCAACACCAAGGCACTGGCTGTGGTCTACGGCCCGCACGAGGTCCATGGAAAGAAATTA
TTCCTTAGATTTGATCTAGATGAAGAAATGGGGCCCCCTGGCAGCAGCCCAACACCAGAGCCTCCACAAAAAGAAGTGCAGAAGGAAGGG
GCTGCGGACCCAAAGCAGGTCGGGGAGCCCAGCGGGCAGAAGACCCTTGATGGATCCTCACGGTCTGCAGAGCTCGTCCCCCAGGGCGAG
GATGATTCTGAGTATTTGGAGAGAGACGCCCCTGCAGGAGATGCTGGGAGGTGGCTGCGTGTCAGCTTTGGTTTGTTTGGCAGCGTTTGG
GTGAACGATTTCTCCAGAGCCAAGAAAGCCAACAAGAGGGGGGACTGGAGGGACCCTTCCCCGAGGTTGGTCCTGCACTTTGGTGGTGGT
GGCTTCCTGGCATTTTATAATTGTCAGTTGTCTTGGAGCTCTTCCCCAGTGGTCACACCCACCTGTGACATCCTGTCTGAGAAGTTCCAT
CGAGGACAAGCCTTAGAAGCTCTAGGCCAGGCTCAGCCTGTCTGCTATACACTGCTGGACCAGAGATACTTCTCAGGGCTAGGGAACATC
ATTAAGAATGAAGCCTTGTACAGAGCTGGGATCCATCCCCTTTCTCTCGGTTCAGTCCTGAGTGCCTCGCGTCGGGAGGTCCTGGTGGAT
CACGTGGTGGAGTTCAGTACAGCCTGGCTGCAGGGCAAGTTCCAAGGCAGACCGCAGCACACACAGGTCTACCAGAAAGAACAGTGCCCT
GCTGGCCACCAGGTCATGAAGGAGGCGTTTGGGCCCGAAGATGGGTTACAGAGGCTCACCTGGTGGTGCCCGCAGTGCCAGCCCCAGTTG
TCAGAGGAGCCAGAGCAGTGCCAGTTCTCCTAAGGAGCTGGTGGTGCTCCTCACGGAACCTTGCCGCTTGGGGAACCTGACGTCTAAGTG
TCCAGAAAGGAGGATGTGGGCAGGGACGGGGTACAGAGGATAGTGTGGGTCAGAGGTGCCAGTAGTATAATATTCGTCTCCCTGGAGTTA
TGTTGAAGGCAGAGTTTTCATAGGGTTAGATTTTTTTTATCCTTTTCTAGTTCAGTTAATTCATCCTGTTGAATTGCACCATCGTGAAAG
ATGGGAAAAATCGTGATGATGGGTAAGGGGAAAACTTCCCGGAAGGCAATGGGGCAAGGAAAAAGAAAGCCTATGGGAAATGGCTGTGCT
CCCAACATAGCTTTGCAGATGATGTGGGTTTTTTTTTTTTTTTTGGTTGTTTGTTTTGAGAGAGAGTCTTGCTCTGTCTCCCTGGCTAGG
GTGTGGTGGTGTGATCTTGGCTCACGGCAGCCTTGCCCTCCCTGGCTCAAGCAGTCTTCATCTCAGCCTCCAGAGTAGCTGGGACTACAG
GCATGTGATATGATGCTCGGCTGATTTTTGTTTACTTTTTAGAGAGATGGGGTCTTGCCATATTTGCCAGGCTGGTTTGAACTCCTACAA
CTCAAGCATTCCTCCCACCTTGGTCTCCCAAAATGTTGGGACCACGGGTGTGAGCCACCGCGCCCAGCTAGCTCCTGTGTTTTGTTTTTG
TTTTGTAACTTTGGTTGATGTTAAGGCCCTCCATTTTGGAAAGCAGGAAAACAGGATTTTTTTTTTTTTATCTTGTTCCCTGGAGGATCC
AGGGATGAGGATAGAGTGGCCTGAGAGCAGTGCTTGGATTCAGCCTCCTGCTGGGTCCTTCTGCTGGATACAGGCACCAAGAGGCGGTCG
TGGAGCAGGGAGCTGCGCCTTCCTGGGGTGCCCGGTGGTGTGTAGAGAAAAGCTGCTTGTTTACTCCTTAAGTCAATGTATTGGTGACTG
TTGATTTGTTGAACAATTCAGGAATCAAGGGCTGTGGAGAAACTCCCTCATGTTGTTGGCAACAGGTGAATGAACCTAGAGCGGTGACAT

>27981_27981_16_EXOSC4-NEIL2_EXOSC4_chr8_145133803_ENST00000525936_NEIL2_chr8_11637108_ENST00000455213_length(amino acids)=343AA_BP=57
MAGLELLSDQGYRVDGRRAGELRKIQARMGVFAQADGSAYIEQGNTKALAVVYGPHEVHGKKLFLRFDLDEEMGPPGSSPTPEPPQKEVQ
KEGAADPKQVGEPSGQKTLDGSSRSAELVPQGEDDSEYLERDAPAGDAGRWLRVSFGLFGSVWVNDFSRAKKANKRGDWRDPSPRLVLHF
GGGGFLAFYNCQLSWSSSPVVTPTCDILSEKFHRGQALEALGQAQPVCYTLLDQRYFSGLGNIIKNEALYRAGIHPLSLGSVLSASRREV

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for EXOSC4-NEIL2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for EXOSC4-NEIL2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for EXOSC4-NEIL2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source