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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:EYA2-SLC2A10 (FusionGDB2 ID:28052)

Fusion Gene Summary for EYA2-SLC2A10

check button Fusion gene summary
Fusion gene informationFusion gene name: EYA2-SLC2A10
Fusion gene ID: 28052
HgeneTgene
Gene symbol

EYA2

SLC2A10

Gene ID

2139

81031

Gene nameEYA transcriptional coactivator and phosphatase 2solute carrier family 2 member 10
SynonymsEAB1ATORS|ATS|GLUT10
Cytomap

20q13.12

20q13.12

Type of geneprotein-codingprotein-coding
Descriptioneyes absent homolog 2solute carrier family 2, facilitated glucose transporter member 10GLUT-10glucose transporter type 10solute carrier family 2 (facilitated glucose transporter), member 10
Modification date2020031320200313
UniProtAcc

O00167

.
Ensembl transtripts involved in fusion geneENST00000317304, ENST00000327619, 
ENST00000357410, ENST00000497428, 
ENST00000486000, ENST00000359271, 
Fusion gene scores* DoF score7 X 5 X 6=2104 X 5 X 3=60
# samples 106
** MAII scorelog2(10/210*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/60*10)=0
Context

PubMed: EYA2 [Title/Abstract] AND SLC2A10 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointEYA2(45644936)-SLC2A10(45353680), # samples:4
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneEYA2

GO:0016576

histone dephosphorylation

19351884


check buttonFusion gene breakpoints across EYA2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SLC2A10 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-5B-A90C-01AEYA2chr20

45633723

+SLC2A10chr20

45353680

+
ChimerDB4UCECTCGA-5B-A90C-01AEYA2chr20

45644936

-SLC2A10chr20

45353680

+
ChimerDB4UCECTCGA-5B-A90C-01AEYA2chr20

45644936

+SLC2A10chr20

45353680

+
ChimerDB4UCECTCGA-5B-A90CEYA2chr20

45633723

+SLC2A10chr20

45353680

+
ChimerDB4UCECTCGA-5B-A90CEYA2chr20

45644936

+SLC2A10chr20

45353680

+
ChimerDB4UCECTCGA-D1-A169-01AEYA2chr20

45523626

+SLC2A10chr20

45353680

+
ChimerDB4UCECTCGA-EY-A212-01AEYA2chr20

45633723

+SLC2A10chr20

45353680

+


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Fusion Gene ORF analysis for EYA2-SLC2A10

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000317304ENST00000486000EYA2chr20

45644936

+SLC2A10chr20

45353680

+
5CDS-intronENST00000317304ENST00000486000EYA2chr20

45633723

+SLC2A10chr20

45353680

+
5CDS-intronENST00000327619ENST00000486000EYA2chr20

45644936

+SLC2A10chr20

45353680

+
5CDS-intronENST00000327619ENST00000486000EYA2chr20

45633723

+SLC2A10chr20

45353680

+
5CDS-intronENST00000357410ENST00000486000EYA2chr20

45644936

+SLC2A10chr20

45353680

+
5CDS-intronENST00000357410ENST00000486000EYA2chr20

45633723

+SLC2A10chr20

45353680

+
5UTR-3CDSENST00000327619ENST00000359271EYA2chr20

45523626

+SLC2A10chr20

45353680

+
5UTR-3CDSENST00000357410ENST00000359271EYA2chr20

45523626

+SLC2A10chr20

45353680

+
5UTR-intronENST00000327619ENST00000486000EYA2chr20

45523626

+SLC2A10chr20

45353680

+
5UTR-intronENST00000357410ENST00000486000EYA2chr20

45523626

+SLC2A10chr20

45353680

+
In-frameENST00000317304ENST00000359271EYA2chr20

45644936

+SLC2A10chr20

45353680

+
In-frameENST00000317304ENST00000359271EYA2chr20

45633723

+SLC2A10chr20

45353680

+
In-frameENST00000327619ENST00000359271EYA2chr20

45644936

+SLC2A10chr20

45353680

+
In-frameENST00000327619ENST00000359271EYA2chr20

45633723

+SLC2A10chr20

45353680

+
In-frameENST00000357410ENST00000359271EYA2chr20

45644936

+SLC2A10chr20

45353680

+
In-frameENST00000357410ENST00000359271EYA2chr20

45633723

+SLC2A10chr20

45353680

+
intron-3CDSENST00000317304ENST00000359271EYA2chr20

45523626

+SLC2A10chr20

45353680

+
intron-3CDSENST00000497428ENST00000359271EYA2chr20

45644936

+SLC2A10chr20

45353680

+
intron-3CDSENST00000497428ENST00000359271EYA2chr20

45633723

+SLC2A10chr20

45353680

+
intron-3CDSENST00000497428ENST00000359271EYA2chr20

45523626

+SLC2A10chr20

45353680

+
intron-intronENST00000317304ENST00000486000EYA2chr20

45523626

+SLC2A10chr20

45353680

+
intron-intronENST00000497428ENST00000486000EYA2chr20

45644936

+SLC2A10chr20

45353680

+
intron-intronENST00000497428ENST00000486000EYA2chr20

45633723

+SLC2A10chr20

45353680

+
intron-intronENST00000497428ENST00000486000EYA2chr20

45523626

+SLC2A10chr20

45353680

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000357410EYA2chr2045644936+ENST00000359271SLC2A10chr2045353680+4903789682410780
ENST00000327619EYA2chr2045644936+ENST00000359271SLC2A10chr2045353680+4903789682410780
ENST00000317304EYA2chr2045644936+ENST00000359271SLC2A10chr2045353680+4539425102046678
ENST00000357410EYA2chr2045633723+ENST00000359271SLC2A10chr2045353680+4786672682293741
ENST00000327619EYA2chr2045633723+ENST00000359271SLC2A10chr2045353680+4786672682293741
ENST00000317304EYA2chr2045633723+ENST00000359271SLC2A10chr2045353680+4422308101929639

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000357410ENST00000359271EYA2chr2045644936+SLC2A10chr2045353680+0.0192817580.98071826
ENST00000327619ENST00000359271EYA2chr2045644936+SLC2A10chr2045353680+0.0192817580.98071826
ENST00000317304ENST00000359271EYA2chr2045644936+SLC2A10chr2045353680+0.0199627020.98003733
ENST00000357410ENST00000359271EYA2chr2045633723+SLC2A10chr2045353680+0.027147650.97285235
ENST00000327619ENST00000359271EYA2chr2045633723+SLC2A10chr2045353680+0.027147650.97285235
ENST00000317304ENST00000359271EYA2chr2045633723+SLC2A10chr2045353680+0.029113580.9708864

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Fusion Genomic Features for EYA2-SLC2A10


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
EYA2chr2045633723+SLC2A10chr2045353679+0.0003703730.9996296
EYA2chr2045644936+SLC2A10chr2045353679+0.0001431170.9998568
EYA2chr2045644936+SLC2A10chr2045353679+0.0001431170.9998568
EYA2chr2045523626+SLC2A10chr2045353679+1.83E-060.9999982
EYA2chr2045633723+SLC2A10chr2045353679+0.0003703730.9996296
EYA2chr2045644936+SLC2A10chr2045353679+0.0001431170.9998568
EYA2chr2045644936+SLC2A10chr2045353679+0.0001431170.9998568
EYA2chr2045523626+SLC2A10chr2045353679+1.83E-060.9999982

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for EYA2-SLC2A10


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:45644936/chr20:45353680)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EYA2

O00167

.
FUNCTION: Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5 (PubMed:12500905, PubMed:23435380). Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19351884). Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Plays an important role in hypaxial muscle development together with SIX1 and DACH2; in this it is functionally redundant with EYA1 (PubMed:12500905). {ECO:0000269|PubMed:12500905, ECO:0000269|PubMed:19351884, ECO:0000269|PubMed:21706047, ECO:0000269|PubMed:23435380}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSLC2A10chr20:45633723chr20:45353680ENST0000035927105242_2481542.0RegionMonosaccharide binding
TgeneSLC2A10chr20:45644936chr20:45353680ENST0000035927105242_2481542.0RegionMonosaccharide binding
TgeneSLC2A10chr20:45633723chr20:45353680ENST0000035927105128_1341542.0Topological domainCytoplasmic
TgeneSLC2A10chr20:45633723chr20:45353680ENST0000035927105156_1661542.0Topological domainExtracellular
TgeneSLC2A10chr20:45633723chr20:45353680ENST0000035927105188_2331542.0Topological domainCytoplasmic
TgeneSLC2A10chr20:45633723chr20:45353680ENST00000359271051_151542.0Topological domainCytoplasmic
TgeneSLC2A10chr20:45633723chr20:45353680ENST0000035927105255_2691542.0Topological domainExtracellular
TgeneSLC2A10chr20:45633723chr20:45353680ENST0000035927105291_2981542.0Topological domainCytoplasmic
TgeneSLC2A10chr20:45633723chr20:45353680ENST0000035927105320_4141542.0Topological domainExtracellular
TgeneSLC2A10chr20:45633723chr20:45353680ENST000003592710537_481542.0Topological domainExtracellular
TgeneSLC2A10chr20:45633723chr20:45353680ENST0000035927105436_4451542.0Topological domainCytoplasmic
TgeneSLC2A10chr20:45633723chr20:45353680ENST0000035927105467_4761542.0Topological domainExtracellular
TgeneSLC2A10chr20:45633723chr20:45353680ENST0000035927105498_5411542.0Topological domainCytoplasmic
TgeneSLC2A10chr20:45633723chr20:45353680ENST000003592710570_771542.0Topological domainCytoplasmic
TgeneSLC2A10chr20:45633723chr20:45353680ENST000003592710599_1061542.0Topological domainExtracellular
TgeneSLC2A10chr20:45644936chr20:45353680ENST0000035927105128_1341542.0Topological domainCytoplasmic
TgeneSLC2A10chr20:45644936chr20:45353680ENST0000035927105156_1661542.0Topological domainExtracellular
TgeneSLC2A10chr20:45644936chr20:45353680ENST0000035927105188_2331542.0Topological domainCytoplasmic
TgeneSLC2A10chr20:45644936chr20:45353680ENST00000359271051_151542.0Topological domainCytoplasmic
TgeneSLC2A10chr20:45644936chr20:45353680ENST0000035927105255_2691542.0Topological domainExtracellular
TgeneSLC2A10chr20:45644936chr20:45353680ENST0000035927105291_2981542.0Topological domainCytoplasmic
TgeneSLC2A10chr20:45644936chr20:45353680ENST0000035927105320_4141542.0Topological domainExtracellular
TgeneSLC2A10chr20:45644936chr20:45353680ENST000003592710537_481542.0Topological domainExtracellular
TgeneSLC2A10chr20:45644936chr20:45353680ENST0000035927105436_4451542.0Topological domainCytoplasmic
TgeneSLC2A10chr20:45644936chr20:45353680ENST0000035927105467_4761542.0Topological domainExtracellular
TgeneSLC2A10chr20:45644936chr20:45353680ENST0000035927105498_5411542.0Topological domainCytoplasmic
TgeneSLC2A10chr20:45644936chr20:45353680ENST000003592710570_771542.0Topological domainCytoplasmic
TgeneSLC2A10chr20:45644936chr20:45353680ENST000003592710599_1061542.0Topological domainExtracellular
TgeneSLC2A10chr20:45633723chr20:45353680ENST0000035927105107_1271542.0TransmembraneHelical%3B Name%3D4
TgeneSLC2A10chr20:45633723chr20:45353680ENST0000035927105135_1551542.0TransmembraneHelical%3B Name%3D5
TgeneSLC2A10chr20:45633723chr20:45353680ENST0000035927105167_1871542.0TransmembraneHelical%3B Name%3D6
TgeneSLC2A10chr20:45633723chr20:45353680ENST000003592710516_361542.0TransmembraneHelical%3B Name%3D1
TgeneSLC2A10chr20:45633723chr20:45353680ENST0000035927105234_2541542.0TransmembraneHelical%3B Name%3D7
TgeneSLC2A10chr20:45633723chr20:45353680ENST0000035927105270_2901542.0TransmembraneHelical%3B Name%3D8
TgeneSLC2A10chr20:45633723chr20:45353680ENST0000035927105299_3191542.0TransmembraneHelical%3B Name%3D9
TgeneSLC2A10chr20:45633723chr20:45353680ENST0000035927105415_4351542.0TransmembraneHelical%3B Name%3D10
TgeneSLC2A10chr20:45633723chr20:45353680ENST0000035927105446_4661542.0TransmembraneHelical%3B Name%3D11
TgeneSLC2A10chr20:45633723chr20:45353680ENST0000035927105477_4971542.0TransmembraneHelical%3B Name%3D12
TgeneSLC2A10chr20:45633723chr20:45353680ENST000003592710549_691542.0TransmembraneHelical%3B Name%3D2
TgeneSLC2A10chr20:45633723chr20:45353680ENST000003592710578_981542.0TransmembraneHelical%3B Name%3D3
TgeneSLC2A10chr20:45644936chr20:45353680ENST0000035927105107_1271542.0TransmembraneHelical%3B Name%3D4
TgeneSLC2A10chr20:45644936chr20:45353680ENST0000035927105135_1551542.0TransmembraneHelical%3B Name%3D5
TgeneSLC2A10chr20:45644936chr20:45353680ENST0000035927105167_1871542.0TransmembraneHelical%3B Name%3D6
TgeneSLC2A10chr20:45644936chr20:45353680ENST000003592710516_361542.0TransmembraneHelical%3B Name%3D1
TgeneSLC2A10chr20:45644936chr20:45353680ENST0000035927105234_2541542.0TransmembraneHelical%3B Name%3D7
TgeneSLC2A10chr20:45644936chr20:45353680ENST0000035927105270_2901542.0TransmembraneHelical%3B Name%3D8
TgeneSLC2A10chr20:45644936chr20:45353680ENST0000035927105299_3191542.0TransmembraneHelical%3B Name%3D9
TgeneSLC2A10chr20:45644936chr20:45353680ENST0000035927105415_4351542.0TransmembraneHelical%3B Name%3D10
TgeneSLC2A10chr20:45644936chr20:45353680ENST0000035927105446_4661542.0TransmembraneHelical%3B Name%3D11
TgeneSLC2A10chr20:45644936chr20:45353680ENST0000035927105477_4971542.0TransmembraneHelical%3B Name%3D12
TgeneSLC2A10chr20:45644936chr20:45353680ENST000003592710549_691542.0TransmembraneHelical%3B Name%3D2
TgeneSLC2A10chr20:45644936chr20:45353680ENST000003592710578_981542.0TransmembraneHelical%3B Name%3D3

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for EYA2-SLC2A10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>28052_28052_1_EYA2-SLC2A10_EYA2_chr20_45633723_ENST00000317304_SLC2A10_chr20_45353680_ENST00000359271_length(transcript)=4422nt_BP=308nt
GTACAAGGAAATGGTAGAACTAGTGATCTCACCCAGCCTCACTGTAAACAGCGATTGTCTGGATAAACTGAAGTTTAACCGTGCTGACGC
TGCTGTGTGGACTCTGAGTGACAGACAAGGCATCACCAAATCGGCCCCCCTGAGAGTGTCCCAGCTCTTCTCCAGATCTTGCCCACGTGT
CCTCCCCCGCCAGCCTTCCACAGCCATGGCAGCCTACGGCCAGACGCAGTACAGTGCGGGGATCCAGCAGGCTACCCCCTATACAGCTTA
CCCACCTCCAGCACAAGCCTATGGAATCCCTTCCTACAGCCACTCCCCACCTGTCCTGCCTTTGTGTGCCTCTGTGTCTTTGCTGGGTGG
CCTGACCTTTGGTTATGAACTGGCAGTCATATCAGGTGCCCTGCTGCCACTGCAGCTTGACTTTGGGCTAAGCTGCTTGGAGCAGGAGTT
CCTGGTGGGCAGCCTGCTCCTGGGGGCTCTCCTCGCCTCCCTGGTTGGTGGCTTCCTCATTGACTGCTATGGCAGGAAGCAAGCCATCCT
CGGGAGCAACTTGGTGCTGCTGGCAGGCAGCCTGACCCTGGGCCTGGCTGGTTCCCTGGCCTGGCTGGTCCTGGGCCGCGCTGTGGTTGG
CTTCGCCATTTCCCTCTCCTCCATGGCTTGCTGTATCTACGTGTCAGAGCTGGTGGGGCCACGGCAGCGGGGAGTGCTGGTGTCCCTCTA
TGAGGCAGGCATCACCGTGGGCATCCTGCTCTCCTATGCCCTCAACTATGCACTGGCTGGTACCCCCTGGGGATGGAGGCACATGTTCGG
CTGGGCCACTGCACCTGCTGTCCTGCAATCCCTCAGCCTCCTCTTCCTCCCTGCTGGTACAGATGAGACTGCAACACACAAGGACCTCAT
CCCACTCCAGGGAGGTGAGGCCCCCAAGCTGGGCCCGGGGAGGCCACGGTACTCCTTTCTGGACCTCTTCAGGGCACGCGATAACATGCG
AGGCCGGACCACAGTGGGCCTGGGGCTGGTGCTCTTCCAGCAACTAACAGGGCAGCCCAACGTGCTGTGCTATGCCTCCACCATCTTCAG
CTCCGTTGGTTTCCATGGGGGATCCTCAGCCGTGCTGGCCTCTGTGGGGCTTGGCGCAGTGAAGGTGGCAGCTACCCTGACCGCCATGGG
GCTGGTGGACCGTGCAGGCCGCAGGGCTCTGTTGCTAGCTGGCTGTGCCCTCATGGCCCTGTCCGTCAGTGGCATAGGCCTCGTCAGCTT
TGCCGTGCCCATGGACTCAGGCCCAAGCTGTCTGGCTGTGCCCAATGCCACCGGGCAGACAGGCCTCCCTGGAGACTCTGGCCTGCTGCA
GGACTCCTCTCTACCTCCCATTCCAAGGACCAATGAGGACCAAAGGGAGCCAATCTTGTCCACTGCTAAGAAAACCAAGCCCCATCCCAG
ATCTGGAGACCCCTCAGCCCCTCCTCGGCTGGCCCTGAGCTCTGCCCTCCCTGGGCCCCCTCTGCCCGCTCGGGGGCATGCACTGCTGCG
CTGGACCGCACTGCTGTGCCTGATGGTCTTTGTCAGTGCCTTCTCCTTTGGGTTTGGGCCAGTGACCTGGCTTGTCCTCAGCGAGATCTA
CCCTGTGGAGATACGAGGAAGAGCCTTCGCCTTCTGCAACAGCTTCAACTGGGCGGCCAACCTCTTCATCAGCCTCTCCTTCCTCGATCT
CATTGGCACCATCGGCTTGTCCTGGACCTTCCTGCTCTACGGACTGACCGCTGTCCTCGGCCTGGGCTTCATCTATTTATTTGTTCCTGA
AACAAAAGGCCAGTCGTTGGCAGAGATAGACCAGCAGTTCCAGAAGAGACGGTTCACCCTGAGCTTTGGCCACAGGCAGAACTCCACTGG
CATCCCGTACAGCCGCATCGAGATCTCTGCGGCCTCCTGAGGAATCCGTCTGCCTGGAAATTCTGGAACTGTGGCTTTGGCAGACCATCT
CCAGCATCCTGCTTCCTAGGCCCCAGAGCACAAGTTCCAGCTGGTCTTTTGGGAGTGGCCCCTGCCCCCAAAGGTGGTCTGCTTTTGCTG
GGGTAAAAAGGATGAAAGTCTGAGAATGCCCAACTCTTCATTTTGAGTCTCAGGCCCTGAAGGTTCCTGAGGATCTAGCTTCATGCCTCA
GTTTCCCCATTGACTTGCACATCTCTGCAGTATTTATAAGAAGAATATTCTATGAAGTCTTTGTTGCACCATGGACTTTTCTCAAAGAAT
CTCAAGGGTACCAATCCTGGCAGGAAGTCTCTCCCGATATCACCCCTAAATCCAAATGAGGATATCATCTTTTCTAATCTCTTTTTTCAA
CTGGCTGGGACATTTTCGGAAGGGGGAAGTCTCTTTTTTTACTCTTATCATTTTTTTTTTTTGAGGTGGAGTCTCATTCTGTTGCCCAGG
CTGGCCTGATCTTGGCTCACTGCAACCTCCACCTCCTGAGTTCAAGCGATTCTTGTGCCTCAGCCTCCTAAGCAGCTGGGACTACAGGCG
CATGCAACCATACCCAGCTAATTTATTTTTAGCAGAGATGGGGTTTCACTGTGTTGGCCAGGCTGGTCGTGAACTCCTGAGCTCAAGTGA
TCCACCCACCTCAGCCTCCCAGAGTGCTAGGATTACAGGCCTTTTGACTCTTTTATCTGAGTTTTATTGACCCCTCTAATTCTCTTACCC
AGAATATTTATCCTTCACCAGCAACTCTGACTCTTTGACGGGAGGCCTCAGTTCTAGTCCTTGGTCTGCTGGTGTCATTGCTGTAGGAAT
GACCACGGGCCTCAGTTTCCCCATTTGTATAATGGGAAGCCTGTACCAGGTCATTCTTAAGATTTCTCCTGACTCCAGTGAGCTGGAATT
CTAAATGCTGGTCTAGGAGCTGTCTCCAGGATGGTGCAGGATGGCTTTGCGGAAAGGAGATGGGTTTGGAGGCCAACAAACCTGCTTGTC
AATATTGCCTTTGCCTCTTGGCAGCCCTTGAACTTGAGTAAATAACAACTCCCTGAACCTCAGTTTCCTCATCTGCAGAATGGGGATAAT
TATGTCCCAGGGGTATATTTAGACCCTGTTTCCTTTCAGGAGGGTCCCCAGCTGGTCCAGGGCCTGGGAAATTTCTACTTATCCTCATTA
CCCAGGTCCCTCCTTTGGACCCTGTAAAGGGTCAGGGTGAATCAGATGGGGGACTGAGCAAGTAGCTATGACTGCAGATCATGTAAGGAA
GGGACTGACAAGAAGCTCCCAGATGCTGGGGAGAATGAAGAGCTAAAATAGATCCTAGGTGCTGGATGCTTTGTCATCCATGCGTGCACA
TATGGGTGCTGGCAGAGCCCCCAAGGACTCTGGCCTCTCGAGTTCTCCTATCTTCTCCATTCTAGATGCTTCCCTTGTATCCAGTGATGT
GCTGGAGCTGGCTTTGCCAAGCTTGTGAGAGCTGGTTGCTACATTTTCAGGATTTTTACAAGTTGGTAAACACAGCCATTATAAAAAATT
AAATGATTTAAATTTATAATTAAGTAAATTACATTAAAACAAAAAAATTATACTCAAAATTCATTACTTAATTTTACTACCTGTTACTAT
TATCTGTGCTTTTGAGGCTATTTCTACATAGTAACTCTTATGGAGACCTAGGGGAGACACCGCGCATCTCTTCCTGATTCCCCACTCAAT
GACATCATGTTAGTCTTTGGTTGCTTAACTGGCTGTGGGGAGTGTTTTTGTATCACAAAGATTAGAGAGGACTACACATCAGGGCTTGAT
TTATTGTTTGTTGATTTTCTAGACTTCAGAACATGCTGGATAAAATGTCAGTAATGCAAATTAAACTTTAAAGTATGTCTTGTTTGTAGC
CAATACATGGTGTATAGCACCAAAAAATGGAGGGATTATTCTTCCAGTAGTTGAACACTGTCATCCGTTTCAGCTGACAGCTGCTCAAAT
CATTTAAGAAGGAGTTCTGACATTCATTTTCATTGTTTTACTTTTGTCTTCCTCACTAGTGTAAACAAAAATTTCAACCAGCATTCATGC
CGAACCTATACCCATTCTTCAGTGCCTAGCTGTACAGTTATCAGGGATTTTTATTTGTAGTCTAATTTTGTCAAATCATGGCCAAATCGC
AGTGATAGTTGACTTTGGATACAAGGTTTGGCAAAAAAAAAAATATTAACAAAATATTCTGTAAGAATCAATTGTCTATATGGAATTTAG
GATAAAGAATATTTACAATAAAGAATATTTACAATAAAGAGTTTATTATTATTTGTAAGTTGTGTGCAACAAACATACCCTTTATCTCTG
TAAAATTTATACACACAAAAATTAACAAAAGATTCTGTAAGAATTAATTGGCTATATGGAATTTAGGATAGAATATTTACAATAAAGAGT

>28052_28052_1_EYA2-SLC2A10_EYA2_chr20_45633723_ENST00000317304_SLC2A10_chr20_45353680_ENST00000359271_length(amino acids)=639AA_BP=100
MVELVISPSLTVNSDCLDKLKFNRADAAVWTLSDRQGITKSAPLRVSQLFSRSCPRVLPRQPSTAMAAYGQTQYSAGIQQATPYTAYPPP
AQAYGIPSYSHSPPVLPLCASVSLLGGLTFGYELAVISGALLPLQLDFGLSCLEQEFLVGSLLLGALLASLVGGFLIDCYGRKQAILGSN
LVLLAGSLTLGLAGSLAWLVLGRAVVGFAISLSSMACCIYVSELVGPRQRGVLVSLYEAGITVGILLSYALNYALAGTPWGWRHMFGWAT
APAVLQSLSLLFLPAGTDETATHKDLIPLQGGEAPKLGPGRPRYSFLDLFRARDNMRGRTTVGLGLVLFQQLTGQPNVLCYASTIFSSVG
FHGGSSAVLASVGLGAVKVAATLTAMGLVDRAGRRALLLAGCALMALSVSGIGLVSFAVPMDSGPSCLAVPNATGQTGLPGDSGLLQDSS
LPPIPRTNEDQREPILSTAKKTKPHPRSGDPSAPPRLALSSALPGPPLPARGHALLRWTALLCLMVFVSAFSFGFGPVTWLVLSEIYPVE
IRGRAFAFCNSFNWAANLFISLSFLDLIGTIGLSWTFLLYGLTAVLGLGFIYLFVPETKGQSLAEIDQQFQKRRFTLSFGHRQNSTGIPY

--------------------------------------------------------------
>28052_28052_2_EYA2-SLC2A10_EYA2_chr20_45633723_ENST00000327619_SLC2A10_chr20_45353680_ENST00000359271_length(transcript)=4786nt_BP=672nt
GCGCGCTCTGCTCGGCTGCAGGCTCAGGAAGCGGCGCGGCGGCACGTGCTGGGCCAGAGCCCCGCGCCCTGCGTCCAGCCGCCGGGTGTG
TGCGCCCGCGTAGCCCAGCGTCGCGCCTCGGCGCCCCCACGCGCCCACGCAGCGGCGCGGGGACCCGGGCGGGGGCAGAGGGAGGGCCCG
GCCCAGGGAGGAGAAGGGGCCGGTCCTCCCGGCGCAGGCAGCAGCCGCGGCAGCCCAGGAGGCGGAGGCAGCGGCAACGGCAGAGACAGC
AACGTGCCCGCCGCAGTCAGCCCGGCCTCGTCGGACCCGCACCGGCCCGCCCGCCCGCCCGCACCGCGTCGGGGCGCCCTCTCCACTGCG
CGCGGTACAAGGAAATGGTAGAACTAGTGATCTCACCCAGCCTCACTGTAAACAGCGATTGTCTGGATAAACTGAAGTTTAACCGTGCTG
ACGCTGCTGTGTGGACTCTGAGTGACAGACAAGGCATCACCAAATCGGCCCCCCTGAGAGTGTCCCAGCTCTTCTCCAGATCTTGCCCAC
GTGTCCTCCCCCGCCAGCCTTCCACAGCCATGGCAGCCTACGGCCAGACGCAGTACAGTGCGGGGATCCAGCAGGCTACCCCCTATACAG
CTTACCCACCTCCAGCACAAGCCTATGGAATCCCTTCCTACAGCCACTCCCCACCTGTCCTGCCTTTGTGTGCCTCTGTGTCTTTGCTGG
GTGGCCTGACCTTTGGTTATGAACTGGCAGTCATATCAGGTGCCCTGCTGCCACTGCAGCTTGACTTTGGGCTAAGCTGCTTGGAGCAGG
AGTTCCTGGTGGGCAGCCTGCTCCTGGGGGCTCTCCTCGCCTCCCTGGTTGGTGGCTTCCTCATTGACTGCTATGGCAGGAAGCAAGCCA
TCCTCGGGAGCAACTTGGTGCTGCTGGCAGGCAGCCTGACCCTGGGCCTGGCTGGTTCCCTGGCCTGGCTGGTCCTGGGCCGCGCTGTGG
TTGGCTTCGCCATTTCCCTCTCCTCCATGGCTTGCTGTATCTACGTGTCAGAGCTGGTGGGGCCACGGCAGCGGGGAGTGCTGGTGTCCC
TCTATGAGGCAGGCATCACCGTGGGCATCCTGCTCTCCTATGCCCTCAACTATGCACTGGCTGGTACCCCCTGGGGATGGAGGCACATGT
TCGGCTGGGCCACTGCACCTGCTGTCCTGCAATCCCTCAGCCTCCTCTTCCTCCCTGCTGGTACAGATGAGACTGCAACACACAAGGACC
TCATCCCACTCCAGGGAGGTGAGGCCCCCAAGCTGGGCCCGGGGAGGCCACGGTACTCCTTTCTGGACCTCTTCAGGGCACGCGATAACA
TGCGAGGCCGGACCACAGTGGGCCTGGGGCTGGTGCTCTTCCAGCAACTAACAGGGCAGCCCAACGTGCTGTGCTATGCCTCCACCATCT
TCAGCTCCGTTGGTTTCCATGGGGGATCCTCAGCCGTGCTGGCCTCTGTGGGGCTTGGCGCAGTGAAGGTGGCAGCTACCCTGACCGCCA
TGGGGCTGGTGGACCGTGCAGGCCGCAGGGCTCTGTTGCTAGCTGGCTGTGCCCTCATGGCCCTGTCCGTCAGTGGCATAGGCCTCGTCA
GCTTTGCCGTGCCCATGGACTCAGGCCCAAGCTGTCTGGCTGTGCCCAATGCCACCGGGCAGACAGGCCTCCCTGGAGACTCTGGCCTGC
TGCAGGACTCCTCTCTACCTCCCATTCCAAGGACCAATGAGGACCAAAGGGAGCCAATCTTGTCCACTGCTAAGAAAACCAAGCCCCATC
CCAGATCTGGAGACCCCTCAGCCCCTCCTCGGCTGGCCCTGAGCTCTGCCCTCCCTGGGCCCCCTCTGCCCGCTCGGGGGCATGCACTGC
TGCGCTGGACCGCACTGCTGTGCCTGATGGTCTTTGTCAGTGCCTTCTCCTTTGGGTTTGGGCCAGTGACCTGGCTTGTCCTCAGCGAGA
TCTACCCTGTGGAGATACGAGGAAGAGCCTTCGCCTTCTGCAACAGCTTCAACTGGGCGGCCAACCTCTTCATCAGCCTCTCCTTCCTCG
ATCTCATTGGCACCATCGGCTTGTCCTGGACCTTCCTGCTCTACGGACTGACCGCTGTCCTCGGCCTGGGCTTCATCTATTTATTTGTTC
CTGAAACAAAAGGCCAGTCGTTGGCAGAGATAGACCAGCAGTTCCAGAAGAGACGGTTCACCCTGAGCTTTGGCCACAGGCAGAACTCCA
CTGGCATCCCGTACAGCCGCATCGAGATCTCTGCGGCCTCCTGAGGAATCCGTCTGCCTGGAAATTCTGGAACTGTGGCTTTGGCAGACC
ATCTCCAGCATCCTGCTTCCTAGGCCCCAGAGCACAAGTTCCAGCTGGTCTTTTGGGAGTGGCCCCTGCCCCCAAAGGTGGTCTGCTTTT
GCTGGGGTAAAAAGGATGAAAGTCTGAGAATGCCCAACTCTTCATTTTGAGTCTCAGGCCCTGAAGGTTCCTGAGGATCTAGCTTCATGC
CTCAGTTTCCCCATTGACTTGCACATCTCTGCAGTATTTATAAGAAGAATATTCTATGAAGTCTTTGTTGCACCATGGACTTTTCTCAAA
GAATCTCAAGGGTACCAATCCTGGCAGGAAGTCTCTCCCGATATCACCCCTAAATCCAAATGAGGATATCATCTTTTCTAATCTCTTTTT
TCAACTGGCTGGGACATTTTCGGAAGGGGGAAGTCTCTTTTTTTACTCTTATCATTTTTTTTTTTTGAGGTGGAGTCTCATTCTGTTGCC
CAGGCTGGCCTGATCTTGGCTCACTGCAACCTCCACCTCCTGAGTTCAAGCGATTCTTGTGCCTCAGCCTCCTAAGCAGCTGGGACTACA
GGCGCATGCAACCATACCCAGCTAATTTATTTTTAGCAGAGATGGGGTTTCACTGTGTTGGCCAGGCTGGTCGTGAACTCCTGAGCTCAA
GTGATCCACCCACCTCAGCCTCCCAGAGTGCTAGGATTACAGGCCTTTTGACTCTTTTATCTGAGTTTTATTGACCCCTCTAATTCTCTT
ACCCAGAATATTTATCCTTCACCAGCAACTCTGACTCTTTGACGGGAGGCCTCAGTTCTAGTCCTTGGTCTGCTGGTGTCATTGCTGTAG
GAATGACCACGGGCCTCAGTTTCCCCATTTGTATAATGGGAAGCCTGTACCAGGTCATTCTTAAGATTTCTCCTGACTCCAGTGAGCTGG
AATTCTAAATGCTGGTCTAGGAGCTGTCTCCAGGATGGTGCAGGATGGCTTTGCGGAAAGGAGATGGGTTTGGAGGCCAACAAACCTGCT
TGTCAATATTGCCTTTGCCTCTTGGCAGCCCTTGAACTTGAGTAAATAACAACTCCCTGAACCTCAGTTTCCTCATCTGCAGAATGGGGA
TAATTATGTCCCAGGGGTATATTTAGACCCTGTTTCCTTTCAGGAGGGTCCCCAGCTGGTCCAGGGCCTGGGAAATTTCTACTTATCCTC
ATTACCCAGGTCCCTCCTTTGGACCCTGTAAAGGGTCAGGGTGAATCAGATGGGGGACTGAGCAAGTAGCTATGACTGCAGATCATGTAA
GGAAGGGACTGACAAGAAGCTCCCAGATGCTGGGGAGAATGAAGAGCTAAAATAGATCCTAGGTGCTGGATGCTTTGTCATCCATGCGTG
CACATATGGGTGCTGGCAGAGCCCCCAAGGACTCTGGCCTCTCGAGTTCTCCTATCTTCTCCATTCTAGATGCTTCCCTTGTATCCAGTG
ATGTGCTGGAGCTGGCTTTGCCAAGCTTGTGAGAGCTGGTTGCTACATTTTCAGGATTTTTACAAGTTGGTAAACACAGCCATTATAAAA
AATTAAATGATTTAAATTTATAATTAAGTAAATTACATTAAAACAAAAAAATTATACTCAAAATTCATTACTTAATTTTACTACCTGTTA
CTATTATCTGTGCTTTTGAGGCTATTTCTACATAGTAACTCTTATGGAGACCTAGGGGAGACACCGCGCATCTCTTCCTGATTCCCCACT
CAATGACATCATGTTAGTCTTTGGTTGCTTAACTGGCTGTGGGGAGTGTTTTTGTATCACAAAGATTAGAGAGGACTACACATCAGGGCT
TGATTTATTGTTTGTTGATTTTCTAGACTTCAGAACATGCTGGATAAAATGTCAGTAATGCAAATTAAACTTTAAAGTATGTCTTGTTTG
TAGCCAATACATGGTGTATAGCACCAAAAAATGGAGGGATTATTCTTCCAGTAGTTGAACACTGTCATCCGTTTCAGCTGACAGCTGCTC
AAATCATTTAAGAAGGAGTTCTGACATTCATTTTCATTGTTTTACTTTTGTCTTCCTCACTAGTGTAAACAAAAATTTCAACCAGCATTC
ATGCCGAACCTATACCCATTCTTCAGTGCCTAGCTGTACAGTTATCAGGGATTTTTATTTGTAGTCTAATTTTGTCAAATCATGGCCAAA
TCGCAGTGATAGTTGACTTTGGATACAAGGTTTGGCAAAAAAAAAAATATTAACAAAATATTCTGTAAGAATCAATTGTCTATATGGAAT
TTAGGATAAAGAATATTTACAATAAAGAATATTTACAATAAAGAGTTTATTATTATTTGTAAGTTGTGTGCAACAAACATACCCTTTATC
TCTGTAAAATTTATACACACAAAAATTAACAAAAGATTCTGTAAGAATTAATTGGCTATATGGAATTTAGGATAGAATATTTACAATAAA

>28052_28052_2_EYA2-SLC2A10_EYA2_chr20_45633723_ENST00000327619_SLC2A10_chr20_45353680_ENST00000359271_length(amino acids)=741AA_BP=202
MRPAAGCVRPRSPASRLGAPTRPRSGAGTRAGAEGGPGPGRRRGRSSRRRQQPRQPRRRRQRQRQRQQRARRSQPGLVGPAPARPPARTA
SGRPLHCARYKEMVELVISPSLTVNSDCLDKLKFNRADAAVWTLSDRQGITKSAPLRVSQLFSRSCPRVLPRQPSTAMAAYGQTQYSAGI
QQATPYTAYPPPAQAYGIPSYSHSPPVLPLCASVSLLGGLTFGYELAVISGALLPLQLDFGLSCLEQEFLVGSLLLGALLASLVGGFLID
CYGRKQAILGSNLVLLAGSLTLGLAGSLAWLVLGRAVVGFAISLSSMACCIYVSELVGPRQRGVLVSLYEAGITVGILLSYALNYALAGT
PWGWRHMFGWATAPAVLQSLSLLFLPAGTDETATHKDLIPLQGGEAPKLGPGRPRYSFLDLFRARDNMRGRTTVGLGLVLFQQLTGQPNV
LCYASTIFSSVGFHGGSSAVLASVGLGAVKVAATLTAMGLVDRAGRRALLLAGCALMALSVSGIGLVSFAVPMDSGPSCLAVPNATGQTG
LPGDSGLLQDSSLPPIPRTNEDQREPILSTAKKTKPHPRSGDPSAPPRLALSSALPGPPLPARGHALLRWTALLCLMVFVSAFSFGFGPV
TWLVLSEIYPVEIRGRAFAFCNSFNWAANLFISLSFLDLIGTIGLSWTFLLYGLTAVLGLGFIYLFVPETKGQSLAEIDQQFQKRRFTLS

--------------------------------------------------------------
>28052_28052_3_EYA2-SLC2A10_EYA2_chr20_45633723_ENST00000357410_SLC2A10_chr20_45353680_ENST00000359271_length(transcript)=4786nt_BP=672nt
GCGCGCTCTGCTCGGCTGCAGGCTCAGGAAGCGGCGCGGCGGCACGTGCTGGGCCAGAGCCCCGCGCCCTGCGTCCAGCCGCCGGGTGTG
TGCGCCCGCGTAGCCCAGCGTCGCGCCTCGGCGCCCCCACGCGCCCACGCAGCGGCGCGGGGACCCGGGCGGGGGCAGAGGGAGGGCCCG
GCCCAGGGAGGAGAAGGGGCCGGTCCTCCCGGCGCAGGCAGCAGCCGCGGCAGCCCAGGAGGCGGAGGCAGCGGCAACGGCAGAGACAGC
AACGTGCCCGCCGCAGTCAGCCCGGCCTCGTCGGACCCGCACCGGCCCGCCCGCCCGCCCGCACCGCGTCGGGGCGCCCTCTCCACTGCG
CGCGGTACAAGGAAATGGTAGAACTAGTGATCTCACCCAGCCTCACTGTAAACAGCGATTGTCTGGATAAACTGAAGTTTAACCGTGCTG
ACGCTGCTGTGTGGACTCTGAGTGACAGACAAGGCATCACCAAATCGGCCCCCCTGAGAGTGTCCCAGCTCTTCTCCAGATCTTGCCCAC
GTGTCCTCCCCCGCCAGCCTTCCACAGCCATGGCAGCCTACGGCCAGACGCAGTACAGTGCGGGGATCCAGCAGGCTACCCCCTATACAG
CTTACCCACCTCCAGCACAAGCCTATGGAATCCCTTCCTACAGCCACTCCCCACCTGTCCTGCCTTTGTGTGCCTCTGTGTCTTTGCTGG
GTGGCCTGACCTTTGGTTATGAACTGGCAGTCATATCAGGTGCCCTGCTGCCACTGCAGCTTGACTTTGGGCTAAGCTGCTTGGAGCAGG
AGTTCCTGGTGGGCAGCCTGCTCCTGGGGGCTCTCCTCGCCTCCCTGGTTGGTGGCTTCCTCATTGACTGCTATGGCAGGAAGCAAGCCA
TCCTCGGGAGCAACTTGGTGCTGCTGGCAGGCAGCCTGACCCTGGGCCTGGCTGGTTCCCTGGCCTGGCTGGTCCTGGGCCGCGCTGTGG
TTGGCTTCGCCATTTCCCTCTCCTCCATGGCTTGCTGTATCTACGTGTCAGAGCTGGTGGGGCCACGGCAGCGGGGAGTGCTGGTGTCCC
TCTATGAGGCAGGCATCACCGTGGGCATCCTGCTCTCCTATGCCCTCAACTATGCACTGGCTGGTACCCCCTGGGGATGGAGGCACATGT
TCGGCTGGGCCACTGCACCTGCTGTCCTGCAATCCCTCAGCCTCCTCTTCCTCCCTGCTGGTACAGATGAGACTGCAACACACAAGGACC
TCATCCCACTCCAGGGAGGTGAGGCCCCCAAGCTGGGCCCGGGGAGGCCACGGTACTCCTTTCTGGACCTCTTCAGGGCACGCGATAACA
TGCGAGGCCGGACCACAGTGGGCCTGGGGCTGGTGCTCTTCCAGCAACTAACAGGGCAGCCCAACGTGCTGTGCTATGCCTCCACCATCT
TCAGCTCCGTTGGTTTCCATGGGGGATCCTCAGCCGTGCTGGCCTCTGTGGGGCTTGGCGCAGTGAAGGTGGCAGCTACCCTGACCGCCA
TGGGGCTGGTGGACCGTGCAGGCCGCAGGGCTCTGTTGCTAGCTGGCTGTGCCCTCATGGCCCTGTCCGTCAGTGGCATAGGCCTCGTCA
GCTTTGCCGTGCCCATGGACTCAGGCCCAAGCTGTCTGGCTGTGCCCAATGCCACCGGGCAGACAGGCCTCCCTGGAGACTCTGGCCTGC
TGCAGGACTCCTCTCTACCTCCCATTCCAAGGACCAATGAGGACCAAAGGGAGCCAATCTTGTCCACTGCTAAGAAAACCAAGCCCCATC
CCAGATCTGGAGACCCCTCAGCCCCTCCTCGGCTGGCCCTGAGCTCTGCCCTCCCTGGGCCCCCTCTGCCCGCTCGGGGGCATGCACTGC
TGCGCTGGACCGCACTGCTGTGCCTGATGGTCTTTGTCAGTGCCTTCTCCTTTGGGTTTGGGCCAGTGACCTGGCTTGTCCTCAGCGAGA
TCTACCCTGTGGAGATACGAGGAAGAGCCTTCGCCTTCTGCAACAGCTTCAACTGGGCGGCCAACCTCTTCATCAGCCTCTCCTTCCTCG
ATCTCATTGGCACCATCGGCTTGTCCTGGACCTTCCTGCTCTACGGACTGACCGCTGTCCTCGGCCTGGGCTTCATCTATTTATTTGTTC
CTGAAACAAAAGGCCAGTCGTTGGCAGAGATAGACCAGCAGTTCCAGAAGAGACGGTTCACCCTGAGCTTTGGCCACAGGCAGAACTCCA
CTGGCATCCCGTACAGCCGCATCGAGATCTCTGCGGCCTCCTGAGGAATCCGTCTGCCTGGAAATTCTGGAACTGTGGCTTTGGCAGACC
ATCTCCAGCATCCTGCTTCCTAGGCCCCAGAGCACAAGTTCCAGCTGGTCTTTTGGGAGTGGCCCCTGCCCCCAAAGGTGGTCTGCTTTT
GCTGGGGTAAAAAGGATGAAAGTCTGAGAATGCCCAACTCTTCATTTTGAGTCTCAGGCCCTGAAGGTTCCTGAGGATCTAGCTTCATGC
CTCAGTTTCCCCATTGACTTGCACATCTCTGCAGTATTTATAAGAAGAATATTCTATGAAGTCTTTGTTGCACCATGGACTTTTCTCAAA
GAATCTCAAGGGTACCAATCCTGGCAGGAAGTCTCTCCCGATATCACCCCTAAATCCAAATGAGGATATCATCTTTTCTAATCTCTTTTT
TCAACTGGCTGGGACATTTTCGGAAGGGGGAAGTCTCTTTTTTTACTCTTATCATTTTTTTTTTTTGAGGTGGAGTCTCATTCTGTTGCC
CAGGCTGGCCTGATCTTGGCTCACTGCAACCTCCACCTCCTGAGTTCAAGCGATTCTTGTGCCTCAGCCTCCTAAGCAGCTGGGACTACA
GGCGCATGCAACCATACCCAGCTAATTTATTTTTAGCAGAGATGGGGTTTCACTGTGTTGGCCAGGCTGGTCGTGAACTCCTGAGCTCAA
GTGATCCACCCACCTCAGCCTCCCAGAGTGCTAGGATTACAGGCCTTTTGACTCTTTTATCTGAGTTTTATTGACCCCTCTAATTCTCTT
ACCCAGAATATTTATCCTTCACCAGCAACTCTGACTCTTTGACGGGAGGCCTCAGTTCTAGTCCTTGGTCTGCTGGTGTCATTGCTGTAG
GAATGACCACGGGCCTCAGTTTCCCCATTTGTATAATGGGAAGCCTGTACCAGGTCATTCTTAAGATTTCTCCTGACTCCAGTGAGCTGG
AATTCTAAATGCTGGTCTAGGAGCTGTCTCCAGGATGGTGCAGGATGGCTTTGCGGAAAGGAGATGGGTTTGGAGGCCAACAAACCTGCT
TGTCAATATTGCCTTTGCCTCTTGGCAGCCCTTGAACTTGAGTAAATAACAACTCCCTGAACCTCAGTTTCCTCATCTGCAGAATGGGGA
TAATTATGTCCCAGGGGTATATTTAGACCCTGTTTCCTTTCAGGAGGGTCCCCAGCTGGTCCAGGGCCTGGGAAATTTCTACTTATCCTC
ATTACCCAGGTCCCTCCTTTGGACCCTGTAAAGGGTCAGGGTGAATCAGATGGGGGACTGAGCAAGTAGCTATGACTGCAGATCATGTAA
GGAAGGGACTGACAAGAAGCTCCCAGATGCTGGGGAGAATGAAGAGCTAAAATAGATCCTAGGTGCTGGATGCTTTGTCATCCATGCGTG
CACATATGGGTGCTGGCAGAGCCCCCAAGGACTCTGGCCTCTCGAGTTCTCCTATCTTCTCCATTCTAGATGCTTCCCTTGTATCCAGTG
ATGTGCTGGAGCTGGCTTTGCCAAGCTTGTGAGAGCTGGTTGCTACATTTTCAGGATTTTTACAAGTTGGTAAACACAGCCATTATAAAA
AATTAAATGATTTAAATTTATAATTAAGTAAATTACATTAAAACAAAAAAATTATACTCAAAATTCATTACTTAATTTTACTACCTGTTA
CTATTATCTGTGCTTTTGAGGCTATTTCTACATAGTAACTCTTATGGAGACCTAGGGGAGACACCGCGCATCTCTTCCTGATTCCCCACT
CAATGACATCATGTTAGTCTTTGGTTGCTTAACTGGCTGTGGGGAGTGTTTTTGTATCACAAAGATTAGAGAGGACTACACATCAGGGCT
TGATTTATTGTTTGTTGATTTTCTAGACTTCAGAACATGCTGGATAAAATGTCAGTAATGCAAATTAAACTTTAAAGTATGTCTTGTTTG
TAGCCAATACATGGTGTATAGCACCAAAAAATGGAGGGATTATTCTTCCAGTAGTTGAACACTGTCATCCGTTTCAGCTGACAGCTGCTC
AAATCATTTAAGAAGGAGTTCTGACATTCATTTTCATTGTTTTACTTTTGTCTTCCTCACTAGTGTAAACAAAAATTTCAACCAGCATTC
ATGCCGAACCTATACCCATTCTTCAGTGCCTAGCTGTACAGTTATCAGGGATTTTTATTTGTAGTCTAATTTTGTCAAATCATGGCCAAA
TCGCAGTGATAGTTGACTTTGGATACAAGGTTTGGCAAAAAAAAAAATATTAACAAAATATTCTGTAAGAATCAATTGTCTATATGGAAT
TTAGGATAAAGAATATTTACAATAAAGAATATTTACAATAAAGAGTTTATTATTATTTGTAAGTTGTGTGCAACAAACATACCCTTTATC
TCTGTAAAATTTATACACACAAAAATTAACAAAAGATTCTGTAAGAATTAATTGGCTATATGGAATTTAGGATAGAATATTTACAATAAA

>28052_28052_3_EYA2-SLC2A10_EYA2_chr20_45633723_ENST00000357410_SLC2A10_chr20_45353680_ENST00000359271_length(amino acids)=741AA_BP=202
MRPAAGCVRPRSPASRLGAPTRPRSGAGTRAGAEGGPGPGRRRGRSSRRRQQPRQPRRRRQRQRQRQQRARRSQPGLVGPAPARPPARTA
SGRPLHCARYKEMVELVISPSLTVNSDCLDKLKFNRADAAVWTLSDRQGITKSAPLRVSQLFSRSCPRVLPRQPSTAMAAYGQTQYSAGI
QQATPYTAYPPPAQAYGIPSYSHSPPVLPLCASVSLLGGLTFGYELAVISGALLPLQLDFGLSCLEQEFLVGSLLLGALLASLVGGFLID
CYGRKQAILGSNLVLLAGSLTLGLAGSLAWLVLGRAVVGFAISLSSMACCIYVSELVGPRQRGVLVSLYEAGITVGILLSYALNYALAGT
PWGWRHMFGWATAPAVLQSLSLLFLPAGTDETATHKDLIPLQGGEAPKLGPGRPRYSFLDLFRARDNMRGRTTVGLGLVLFQQLTGQPNV
LCYASTIFSSVGFHGGSSAVLASVGLGAVKVAATLTAMGLVDRAGRRALLLAGCALMALSVSGIGLVSFAVPMDSGPSCLAVPNATGQTG
LPGDSGLLQDSSLPPIPRTNEDQREPILSTAKKTKPHPRSGDPSAPPRLALSSALPGPPLPARGHALLRWTALLCLMVFVSAFSFGFGPV
TWLVLSEIYPVEIRGRAFAFCNSFNWAANLFISLSFLDLIGTIGLSWTFLLYGLTAVLGLGFIYLFVPETKGQSLAEIDQQFQKRRFTLS

--------------------------------------------------------------
>28052_28052_4_EYA2-SLC2A10_EYA2_chr20_45644936_ENST00000317304_SLC2A10_chr20_45353680_ENST00000359271_length(transcript)=4539nt_BP=425nt
GTACAAGGAAATGGTAGAACTAGTGATCTCACCCAGCCTCACTGTAAACAGCGATTGTCTGGATAAACTGAAGTTTAACCGTGCTGACGC
TGCTGTGTGGACTCTGAGTGACAGACAAGGCATCACCAAATCGGCCCCCCTGAGAGTGTCCCAGCTCTTCTCCAGATCTTGCCCACGTGT
CCTCCCCCGCCAGCCTTCCACAGCCATGGCAGCCTACGGCCAGACGCAGTACAGTGCGGGGATCCAGCAGGCTACCCCCTATACAGCTTA
CCCACCTCCAGCACAAGCCTATGGAATCCCTTCCTACAGCATCAAGACAGAAGACAGCTTGAACCATTCCCCTGGCCAGAGTGGATTCCT
CAGCTATGGCTCCAGCTTCAGCACCTCACCCACTGGACAGAGCCCATACACCTACCAGATGCACGGCCACTCCCCACCTGTCCTGCCTTT
GTGTGCCTCTGTGTCTTTGCTGGGTGGCCTGACCTTTGGTTATGAACTGGCAGTCATATCAGGTGCCCTGCTGCCACTGCAGCTTGACTT
TGGGCTAAGCTGCTTGGAGCAGGAGTTCCTGGTGGGCAGCCTGCTCCTGGGGGCTCTCCTCGCCTCCCTGGTTGGTGGCTTCCTCATTGA
CTGCTATGGCAGGAAGCAAGCCATCCTCGGGAGCAACTTGGTGCTGCTGGCAGGCAGCCTGACCCTGGGCCTGGCTGGTTCCCTGGCCTG
GCTGGTCCTGGGCCGCGCTGTGGTTGGCTTCGCCATTTCCCTCTCCTCCATGGCTTGCTGTATCTACGTGTCAGAGCTGGTGGGGCCACG
GCAGCGGGGAGTGCTGGTGTCCCTCTATGAGGCAGGCATCACCGTGGGCATCCTGCTCTCCTATGCCCTCAACTATGCACTGGCTGGTAC
CCCCTGGGGATGGAGGCACATGTTCGGCTGGGCCACTGCACCTGCTGTCCTGCAATCCCTCAGCCTCCTCTTCCTCCCTGCTGGTACAGA
TGAGACTGCAACACACAAGGACCTCATCCCACTCCAGGGAGGTGAGGCCCCCAAGCTGGGCCCGGGGAGGCCACGGTACTCCTTTCTGGA
CCTCTTCAGGGCACGCGATAACATGCGAGGCCGGACCACAGTGGGCCTGGGGCTGGTGCTCTTCCAGCAACTAACAGGGCAGCCCAACGT
GCTGTGCTATGCCTCCACCATCTTCAGCTCCGTTGGTTTCCATGGGGGATCCTCAGCCGTGCTGGCCTCTGTGGGGCTTGGCGCAGTGAA
GGTGGCAGCTACCCTGACCGCCATGGGGCTGGTGGACCGTGCAGGCCGCAGGGCTCTGTTGCTAGCTGGCTGTGCCCTCATGGCCCTGTC
CGTCAGTGGCATAGGCCTCGTCAGCTTTGCCGTGCCCATGGACTCAGGCCCAAGCTGTCTGGCTGTGCCCAATGCCACCGGGCAGACAGG
CCTCCCTGGAGACTCTGGCCTGCTGCAGGACTCCTCTCTACCTCCCATTCCAAGGACCAATGAGGACCAAAGGGAGCCAATCTTGTCCAC
TGCTAAGAAAACCAAGCCCCATCCCAGATCTGGAGACCCCTCAGCCCCTCCTCGGCTGGCCCTGAGCTCTGCCCTCCCTGGGCCCCCTCT
GCCCGCTCGGGGGCATGCACTGCTGCGCTGGACCGCACTGCTGTGCCTGATGGTCTTTGTCAGTGCCTTCTCCTTTGGGTTTGGGCCAGT
GACCTGGCTTGTCCTCAGCGAGATCTACCCTGTGGAGATACGAGGAAGAGCCTTCGCCTTCTGCAACAGCTTCAACTGGGCGGCCAACCT
CTTCATCAGCCTCTCCTTCCTCGATCTCATTGGCACCATCGGCTTGTCCTGGACCTTCCTGCTCTACGGACTGACCGCTGTCCTCGGCCT
GGGCTTCATCTATTTATTTGTTCCTGAAACAAAAGGCCAGTCGTTGGCAGAGATAGACCAGCAGTTCCAGAAGAGACGGTTCACCCTGAG
CTTTGGCCACAGGCAGAACTCCACTGGCATCCCGTACAGCCGCATCGAGATCTCTGCGGCCTCCTGAGGAATCCGTCTGCCTGGAAATTC
TGGAACTGTGGCTTTGGCAGACCATCTCCAGCATCCTGCTTCCTAGGCCCCAGAGCACAAGTTCCAGCTGGTCTTTTGGGAGTGGCCCCT
GCCCCCAAAGGTGGTCTGCTTTTGCTGGGGTAAAAAGGATGAAAGTCTGAGAATGCCCAACTCTTCATTTTGAGTCTCAGGCCCTGAAGG
TTCCTGAGGATCTAGCTTCATGCCTCAGTTTCCCCATTGACTTGCACATCTCTGCAGTATTTATAAGAAGAATATTCTATGAAGTCTTTG
TTGCACCATGGACTTTTCTCAAAGAATCTCAAGGGTACCAATCCTGGCAGGAAGTCTCTCCCGATATCACCCCTAAATCCAAATGAGGAT
ATCATCTTTTCTAATCTCTTTTTTCAACTGGCTGGGACATTTTCGGAAGGGGGAAGTCTCTTTTTTTACTCTTATCATTTTTTTTTTTTG
AGGTGGAGTCTCATTCTGTTGCCCAGGCTGGCCTGATCTTGGCTCACTGCAACCTCCACCTCCTGAGTTCAAGCGATTCTTGTGCCTCAG
CCTCCTAAGCAGCTGGGACTACAGGCGCATGCAACCATACCCAGCTAATTTATTTTTAGCAGAGATGGGGTTTCACTGTGTTGGCCAGGC
TGGTCGTGAACTCCTGAGCTCAAGTGATCCACCCACCTCAGCCTCCCAGAGTGCTAGGATTACAGGCCTTTTGACTCTTTTATCTGAGTT
TTATTGACCCCTCTAATTCTCTTACCCAGAATATTTATCCTTCACCAGCAACTCTGACTCTTTGACGGGAGGCCTCAGTTCTAGTCCTTG
GTCTGCTGGTGTCATTGCTGTAGGAATGACCACGGGCCTCAGTTTCCCCATTTGTATAATGGGAAGCCTGTACCAGGTCATTCTTAAGAT
TTCTCCTGACTCCAGTGAGCTGGAATTCTAAATGCTGGTCTAGGAGCTGTCTCCAGGATGGTGCAGGATGGCTTTGCGGAAAGGAGATGG
GTTTGGAGGCCAACAAACCTGCTTGTCAATATTGCCTTTGCCTCTTGGCAGCCCTTGAACTTGAGTAAATAACAACTCCCTGAACCTCAG
TTTCCTCATCTGCAGAATGGGGATAATTATGTCCCAGGGGTATATTTAGACCCTGTTTCCTTTCAGGAGGGTCCCCAGCTGGTCCAGGGC
CTGGGAAATTTCTACTTATCCTCATTACCCAGGTCCCTCCTTTGGACCCTGTAAAGGGTCAGGGTGAATCAGATGGGGGACTGAGCAAGT
AGCTATGACTGCAGATCATGTAAGGAAGGGACTGACAAGAAGCTCCCAGATGCTGGGGAGAATGAAGAGCTAAAATAGATCCTAGGTGCT
GGATGCTTTGTCATCCATGCGTGCACATATGGGTGCTGGCAGAGCCCCCAAGGACTCTGGCCTCTCGAGTTCTCCTATCTTCTCCATTCT
AGATGCTTCCCTTGTATCCAGTGATGTGCTGGAGCTGGCTTTGCCAAGCTTGTGAGAGCTGGTTGCTACATTTTCAGGATTTTTACAAGT
TGGTAAACACAGCCATTATAAAAAATTAAATGATTTAAATTTATAATTAAGTAAATTACATTAAAACAAAAAAATTATACTCAAAATTCA
TTACTTAATTTTACTACCTGTTACTATTATCTGTGCTTTTGAGGCTATTTCTACATAGTAACTCTTATGGAGACCTAGGGGAGACACCGC
GCATCTCTTCCTGATTCCCCACTCAATGACATCATGTTAGTCTTTGGTTGCTTAACTGGCTGTGGGGAGTGTTTTTGTATCACAAAGATT
AGAGAGGACTACACATCAGGGCTTGATTTATTGTTTGTTGATTTTCTAGACTTCAGAACATGCTGGATAAAATGTCAGTAATGCAAATTA
AACTTTAAAGTATGTCTTGTTTGTAGCCAATACATGGTGTATAGCACCAAAAAATGGAGGGATTATTCTTCCAGTAGTTGAACACTGTCA
TCCGTTTCAGCTGACAGCTGCTCAAATCATTTAAGAAGGAGTTCTGACATTCATTTTCATTGTTTTACTTTTGTCTTCCTCACTAGTGTA
AACAAAAATTTCAACCAGCATTCATGCCGAACCTATACCCATTCTTCAGTGCCTAGCTGTACAGTTATCAGGGATTTTTATTTGTAGTCT
AATTTTGTCAAATCATGGCCAAATCGCAGTGATAGTTGACTTTGGATACAAGGTTTGGCAAAAAAAAAAATATTAACAAAATATTCTGTA
AGAATCAATTGTCTATATGGAATTTAGGATAAAGAATATTTACAATAAAGAATATTTACAATAAAGAGTTTATTATTATTTGTAAGTTGT
GTGCAACAAACATACCCTTTATCTCTGTAAAATTTATACACACAAAAATTAACAAAAGATTCTGTAAGAATTAATTGGCTATATGGAATT

>28052_28052_4_EYA2-SLC2A10_EYA2_chr20_45644936_ENST00000317304_SLC2A10_chr20_45353680_ENST00000359271_length(amino acids)=678AA_BP=138
MVELVISPSLTVNSDCLDKLKFNRADAAVWTLSDRQGITKSAPLRVSQLFSRSCPRVLPRQPSTAMAAYGQTQYSAGIQQATPYTAYPPP
AQAYGIPSYSIKTEDSLNHSPGQSGFLSYGSSFSTSPTGQSPYTYQMHGHSPPVLPLCASVSLLGGLTFGYELAVISGALLPLQLDFGLS
CLEQEFLVGSLLLGALLASLVGGFLIDCYGRKQAILGSNLVLLAGSLTLGLAGSLAWLVLGRAVVGFAISLSSMACCIYVSELVGPRQRG
VLVSLYEAGITVGILLSYALNYALAGTPWGWRHMFGWATAPAVLQSLSLLFLPAGTDETATHKDLIPLQGGEAPKLGPGRPRYSFLDLFR
ARDNMRGRTTVGLGLVLFQQLTGQPNVLCYASTIFSSVGFHGGSSAVLASVGLGAVKVAATLTAMGLVDRAGRRALLLAGCALMALSVSG
IGLVSFAVPMDSGPSCLAVPNATGQTGLPGDSGLLQDSSLPPIPRTNEDQREPILSTAKKTKPHPRSGDPSAPPRLALSSALPGPPLPAR
GHALLRWTALLCLMVFVSAFSFGFGPVTWLVLSEIYPVEIRGRAFAFCNSFNWAANLFISLSFLDLIGTIGLSWTFLLYGLTAVLGLGFI

--------------------------------------------------------------
>28052_28052_5_EYA2-SLC2A10_EYA2_chr20_45644936_ENST00000327619_SLC2A10_chr20_45353680_ENST00000359271_length(transcript)=4903nt_BP=789nt
GCGCGCTCTGCTCGGCTGCAGGCTCAGGAAGCGGCGCGGCGGCACGTGCTGGGCCAGAGCCCCGCGCCCTGCGTCCAGCCGCCGGGTGTG
TGCGCCCGCGTAGCCCAGCGTCGCGCCTCGGCGCCCCCACGCGCCCACGCAGCGGCGCGGGGACCCGGGCGGGGGCAGAGGGAGGGCCCG
GCCCAGGGAGGAGAAGGGGCCGGTCCTCCCGGCGCAGGCAGCAGCCGCGGCAGCCCAGGAGGCGGAGGCAGCGGCAACGGCAGAGACAGC
AACGTGCCCGCCGCAGTCAGCCCGGCCTCGTCGGACCCGCACCGGCCCGCCCGCCCGCCCGCACCGCGTCGGGGCGCCCTCTCCACTGCG
CGCGGTACAAGGAAATGGTAGAACTAGTGATCTCACCCAGCCTCACTGTAAACAGCGATTGTCTGGATAAACTGAAGTTTAACCGTGCTG
ACGCTGCTGTGTGGACTCTGAGTGACAGACAAGGCATCACCAAATCGGCCCCCCTGAGAGTGTCCCAGCTCTTCTCCAGATCTTGCCCAC
GTGTCCTCCCCCGCCAGCCTTCCACAGCCATGGCAGCCTACGGCCAGACGCAGTACAGTGCGGGGATCCAGCAGGCTACCCCCTATACAG
CTTACCCACCTCCAGCACAAGCCTATGGAATCCCTTCCTACAGCATCAAGACAGAAGACAGCTTGAACCATTCCCCTGGCCAGAGTGGAT
TCCTCAGCTATGGCTCCAGCTTCAGCACCTCACCCACTGGACAGAGCCCATACACCTACCAGATGCACGGCCACTCCCCACCTGTCCTGC
CTTTGTGTGCCTCTGTGTCTTTGCTGGGTGGCCTGACCTTTGGTTATGAACTGGCAGTCATATCAGGTGCCCTGCTGCCACTGCAGCTTG
ACTTTGGGCTAAGCTGCTTGGAGCAGGAGTTCCTGGTGGGCAGCCTGCTCCTGGGGGCTCTCCTCGCCTCCCTGGTTGGTGGCTTCCTCA
TTGACTGCTATGGCAGGAAGCAAGCCATCCTCGGGAGCAACTTGGTGCTGCTGGCAGGCAGCCTGACCCTGGGCCTGGCTGGTTCCCTGG
CCTGGCTGGTCCTGGGCCGCGCTGTGGTTGGCTTCGCCATTTCCCTCTCCTCCATGGCTTGCTGTATCTACGTGTCAGAGCTGGTGGGGC
CACGGCAGCGGGGAGTGCTGGTGTCCCTCTATGAGGCAGGCATCACCGTGGGCATCCTGCTCTCCTATGCCCTCAACTATGCACTGGCTG
GTACCCCCTGGGGATGGAGGCACATGTTCGGCTGGGCCACTGCACCTGCTGTCCTGCAATCCCTCAGCCTCCTCTTCCTCCCTGCTGGTA
CAGATGAGACTGCAACACACAAGGACCTCATCCCACTCCAGGGAGGTGAGGCCCCCAAGCTGGGCCCGGGGAGGCCACGGTACTCCTTTC
TGGACCTCTTCAGGGCACGCGATAACATGCGAGGCCGGACCACAGTGGGCCTGGGGCTGGTGCTCTTCCAGCAACTAACAGGGCAGCCCA
ACGTGCTGTGCTATGCCTCCACCATCTTCAGCTCCGTTGGTTTCCATGGGGGATCCTCAGCCGTGCTGGCCTCTGTGGGGCTTGGCGCAG
TGAAGGTGGCAGCTACCCTGACCGCCATGGGGCTGGTGGACCGTGCAGGCCGCAGGGCTCTGTTGCTAGCTGGCTGTGCCCTCATGGCCC
TGTCCGTCAGTGGCATAGGCCTCGTCAGCTTTGCCGTGCCCATGGACTCAGGCCCAAGCTGTCTGGCTGTGCCCAATGCCACCGGGCAGA
CAGGCCTCCCTGGAGACTCTGGCCTGCTGCAGGACTCCTCTCTACCTCCCATTCCAAGGACCAATGAGGACCAAAGGGAGCCAATCTTGT
CCACTGCTAAGAAAACCAAGCCCCATCCCAGATCTGGAGACCCCTCAGCCCCTCCTCGGCTGGCCCTGAGCTCTGCCCTCCCTGGGCCCC
CTCTGCCCGCTCGGGGGCATGCACTGCTGCGCTGGACCGCACTGCTGTGCCTGATGGTCTTTGTCAGTGCCTTCTCCTTTGGGTTTGGGC
CAGTGACCTGGCTTGTCCTCAGCGAGATCTACCCTGTGGAGATACGAGGAAGAGCCTTCGCCTTCTGCAACAGCTTCAACTGGGCGGCCA
ACCTCTTCATCAGCCTCTCCTTCCTCGATCTCATTGGCACCATCGGCTTGTCCTGGACCTTCCTGCTCTACGGACTGACCGCTGTCCTCG
GCCTGGGCTTCATCTATTTATTTGTTCCTGAAACAAAAGGCCAGTCGTTGGCAGAGATAGACCAGCAGTTCCAGAAGAGACGGTTCACCC
TGAGCTTTGGCCACAGGCAGAACTCCACTGGCATCCCGTACAGCCGCATCGAGATCTCTGCGGCCTCCTGAGGAATCCGTCTGCCTGGAA
ATTCTGGAACTGTGGCTTTGGCAGACCATCTCCAGCATCCTGCTTCCTAGGCCCCAGAGCACAAGTTCCAGCTGGTCTTTTGGGAGTGGC
CCCTGCCCCCAAAGGTGGTCTGCTTTTGCTGGGGTAAAAAGGATGAAAGTCTGAGAATGCCCAACTCTTCATTTTGAGTCTCAGGCCCTG
AAGGTTCCTGAGGATCTAGCTTCATGCCTCAGTTTCCCCATTGACTTGCACATCTCTGCAGTATTTATAAGAAGAATATTCTATGAAGTC
TTTGTTGCACCATGGACTTTTCTCAAAGAATCTCAAGGGTACCAATCCTGGCAGGAAGTCTCTCCCGATATCACCCCTAAATCCAAATGA
GGATATCATCTTTTCTAATCTCTTTTTTCAACTGGCTGGGACATTTTCGGAAGGGGGAAGTCTCTTTTTTTACTCTTATCATTTTTTTTT
TTTGAGGTGGAGTCTCATTCTGTTGCCCAGGCTGGCCTGATCTTGGCTCACTGCAACCTCCACCTCCTGAGTTCAAGCGATTCTTGTGCC
TCAGCCTCCTAAGCAGCTGGGACTACAGGCGCATGCAACCATACCCAGCTAATTTATTTTTAGCAGAGATGGGGTTTCACTGTGTTGGCC
AGGCTGGTCGTGAACTCCTGAGCTCAAGTGATCCACCCACCTCAGCCTCCCAGAGTGCTAGGATTACAGGCCTTTTGACTCTTTTATCTG
AGTTTTATTGACCCCTCTAATTCTCTTACCCAGAATATTTATCCTTCACCAGCAACTCTGACTCTTTGACGGGAGGCCTCAGTTCTAGTC
CTTGGTCTGCTGGTGTCATTGCTGTAGGAATGACCACGGGCCTCAGTTTCCCCATTTGTATAATGGGAAGCCTGTACCAGGTCATTCTTA
AGATTTCTCCTGACTCCAGTGAGCTGGAATTCTAAATGCTGGTCTAGGAGCTGTCTCCAGGATGGTGCAGGATGGCTTTGCGGAAAGGAG
ATGGGTTTGGAGGCCAACAAACCTGCTTGTCAATATTGCCTTTGCCTCTTGGCAGCCCTTGAACTTGAGTAAATAACAACTCCCTGAACC
TCAGTTTCCTCATCTGCAGAATGGGGATAATTATGTCCCAGGGGTATATTTAGACCCTGTTTCCTTTCAGGAGGGTCCCCAGCTGGTCCA
GGGCCTGGGAAATTTCTACTTATCCTCATTACCCAGGTCCCTCCTTTGGACCCTGTAAAGGGTCAGGGTGAATCAGATGGGGGACTGAGC
AAGTAGCTATGACTGCAGATCATGTAAGGAAGGGACTGACAAGAAGCTCCCAGATGCTGGGGAGAATGAAGAGCTAAAATAGATCCTAGG
TGCTGGATGCTTTGTCATCCATGCGTGCACATATGGGTGCTGGCAGAGCCCCCAAGGACTCTGGCCTCTCGAGTTCTCCTATCTTCTCCA
TTCTAGATGCTTCCCTTGTATCCAGTGATGTGCTGGAGCTGGCTTTGCCAAGCTTGTGAGAGCTGGTTGCTACATTTTCAGGATTTTTAC
AAGTTGGTAAACACAGCCATTATAAAAAATTAAATGATTTAAATTTATAATTAAGTAAATTACATTAAAACAAAAAAATTATACTCAAAA
TTCATTACTTAATTTTACTACCTGTTACTATTATCTGTGCTTTTGAGGCTATTTCTACATAGTAACTCTTATGGAGACCTAGGGGAGACA
CCGCGCATCTCTTCCTGATTCCCCACTCAATGACATCATGTTAGTCTTTGGTTGCTTAACTGGCTGTGGGGAGTGTTTTTGTATCACAAA
GATTAGAGAGGACTACACATCAGGGCTTGATTTATTGTTTGTTGATTTTCTAGACTTCAGAACATGCTGGATAAAATGTCAGTAATGCAA
ATTAAACTTTAAAGTATGTCTTGTTTGTAGCCAATACATGGTGTATAGCACCAAAAAATGGAGGGATTATTCTTCCAGTAGTTGAACACT
GTCATCCGTTTCAGCTGACAGCTGCTCAAATCATTTAAGAAGGAGTTCTGACATTCATTTTCATTGTTTTACTTTTGTCTTCCTCACTAG
TGTAAACAAAAATTTCAACCAGCATTCATGCCGAACCTATACCCATTCTTCAGTGCCTAGCTGTACAGTTATCAGGGATTTTTATTTGTA
GTCTAATTTTGTCAAATCATGGCCAAATCGCAGTGATAGTTGACTTTGGATACAAGGTTTGGCAAAAAAAAAAATATTAACAAAATATTC
TGTAAGAATCAATTGTCTATATGGAATTTAGGATAAAGAATATTTACAATAAAGAATATTTACAATAAAGAGTTTATTATTATTTGTAAG
TTGTGTGCAACAAACATACCCTTTATCTCTGTAAAATTTATACACACAAAAATTAACAAAAGATTCTGTAAGAATTAATTGGCTATATGG

>28052_28052_5_EYA2-SLC2A10_EYA2_chr20_45644936_ENST00000327619_SLC2A10_chr20_45353680_ENST00000359271_length(amino acids)=780AA_BP=240
MRPAAGCVRPRSPASRLGAPTRPRSGAGTRAGAEGGPGPGRRRGRSSRRRQQPRQPRRRRQRQRQRQQRARRSQPGLVGPAPARPPARTA
SGRPLHCARYKEMVELVISPSLTVNSDCLDKLKFNRADAAVWTLSDRQGITKSAPLRVSQLFSRSCPRVLPRQPSTAMAAYGQTQYSAGI
QQATPYTAYPPPAQAYGIPSYSIKTEDSLNHSPGQSGFLSYGSSFSTSPTGQSPYTYQMHGHSPPVLPLCASVSLLGGLTFGYELAVISG
ALLPLQLDFGLSCLEQEFLVGSLLLGALLASLVGGFLIDCYGRKQAILGSNLVLLAGSLTLGLAGSLAWLVLGRAVVGFAISLSSMACCI
YVSELVGPRQRGVLVSLYEAGITVGILLSYALNYALAGTPWGWRHMFGWATAPAVLQSLSLLFLPAGTDETATHKDLIPLQGGEAPKLGP
GRPRYSFLDLFRARDNMRGRTTVGLGLVLFQQLTGQPNVLCYASTIFSSVGFHGGSSAVLASVGLGAVKVAATLTAMGLVDRAGRRALLL
AGCALMALSVSGIGLVSFAVPMDSGPSCLAVPNATGQTGLPGDSGLLQDSSLPPIPRTNEDQREPILSTAKKTKPHPRSGDPSAPPRLAL
SSALPGPPLPARGHALLRWTALLCLMVFVSAFSFGFGPVTWLVLSEIYPVEIRGRAFAFCNSFNWAANLFISLSFLDLIGTIGLSWTFLL

--------------------------------------------------------------
>28052_28052_6_EYA2-SLC2A10_EYA2_chr20_45644936_ENST00000357410_SLC2A10_chr20_45353680_ENST00000359271_length(transcript)=4903nt_BP=789nt
GCGCGCTCTGCTCGGCTGCAGGCTCAGGAAGCGGCGCGGCGGCACGTGCTGGGCCAGAGCCCCGCGCCCTGCGTCCAGCCGCCGGGTGTG
TGCGCCCGCGTAGCCCAGCGTCGCGCCTCGGCGCCCCCACGCGCCCACGCAGCGGCGCGGGGACCCGGGCGGGGGCAGAGGGAGGGCCCG
GCCCAGGGAGGAGAAGGGGCCGGTCCTCCCGGCGCAGGCAGCAGCCGCGGCAGCCCAGGAGGCGGAGGCAGCGGCAACGGCAGAGACAGC
AACGTGCCCGCCGCAGTCAGCCCGGCCTCGTCGGACCCGCACCGGCCCGCCCGCCCGCCCGCACCGCGTCGGGGCGCCCTCTCCACTGCG
CGCGGTACAAGGAAATGGTAGAACTAGTGATCTCACCCAGCCTCACTGTAAACAGCGATTGTCTGGATAAACTGAAGTTTAACCGTGCTG
ACGCTGCTGTGTGGACTCTGAGTGACAGACAAGGCATCACCAAATCGGCCCCCCTGAGAGTGTCCCAGCTCTTCTCCAGATCTTGCCCAC
GTGTCCTCCCCCGCCAGCCTTCCACAGCCATGGCAGCCTACGGCCAGACGCAGTACAGTGCGGGGATCCAGCAGGCTACCCCCTATACAG
CTTACCCACCTCCAGCACAAGCCTATGGAATCCCTTCCTACAGCATCAAGACAGAAGACAGCTTGAACCATTCCCCTGGCCAGAGTGGAT
TCCTCAGCTATGGCTCCAGCTTCAGCACCTCACCCACTGGACAGAGCCCATACACCTACCAGATGCACGGCCACTCCCCACCTGTCCTGC
CTTTGTGTGCCTCTGTGTCTTTGCTGGGTGGCCTGACCTTTGGTTATGAACTGGCAGTCATATCAGGTGCCCTGCTGCCACTGCAGCTTG
ACTTTGGGCTAAGCTGCTTGGAGCAGGAGTTCCTGGTGGGCAGCCTGCTCCTGGGGGCTCTCCTCGCCTCCCTGGTTGGTGGCTTCCTCA
TTGACTGCTATGGCAGGAAGCAAGCCATCCTCGGGAGCAACTTGGTGCTGCTGGCAGGCAGCCTGACCCTGGGCCTGGCTGGTTCCCTGG
CCTGGCTGGTCCTGGGCCGCGCTGTGGTTGGCTTCGCCATTTCCCTCTCCTCCATGGCTTGCTGTATCTACGTGTCAGAGCTGGTGGGGC
CACGGCAGCGGGGAGTGCTGGTGTCCCTCTATGAGGCAGGCATCACCGTGGGCATCCTGCTCTCCTATGCCCTCAACTATGCACTGGCTG
GTACCCCCTGGGGATGGAGGCACATGTTCGGCTGGGCCACTGCACCTGCTGTCCTGCAATCCCTCAGCCTCCTCTTCCTCCCTGCTGGTA
CAGATGAGACTGCAACACACAAGGACCTCATCCCACTCCAGGGAGGTGAGGCCCCCAAGCTGGGCCCGGGGAGGCCACGGTACTCCTTTC
TGGACCTCTTCAGGGCACGCGATAACATGCGAGGCCGGACCACAGTGGGCCTGGGGCTGGTGCTCTTCCAGCAACTAACAGGGCAGCCCA
ACGTGCTGTGCTATGCCTCCACCATCTTCAGCTCCGTTGGTTTCCATGGGGGATCCTCAGCCGTGCTGGCCTCTGTGGGGCTTGGCGCAG
TGAAGGTGGCAGCTACCCTGACCGCCATGGGGCTGGTGGACCGTGCAGGCCGCAGGGCTCTGTTGCTAGCTGGCTGTGCCCTCATGGCCC
TGTCCGTCAGTGGCATAGGCCTCGTCAGCTTTGCCGTGCCCATGGACTCAGGCCCAAGCTGTCTGGCTGTGCCCAATGCCACCGGGCAGA
CAGGCCTCCCTGGAGACTCTGGCCTGCTGCAGGACTCCTCTCTACCTCCCATTCCAAGGACCAATGAGGACCAAAGGGAGCCAATCTTGT
CCACTGCTAAGAAAACCAAGCCCCATCCCAGATCTGGAGACCCCTCAGCCCCTCCTCGGCTGGCCCTGAGCTCTGCCCTCCCTGGGCCCC
CTCTGCCCGCTCGGGGGCATGCACTGCTGCGCTGGACCGCACTGCTGTGCCTGATGGTCTTTGTCAGTGCCTTCTCCTTTGGGTTTGGGC
CAGTGACCTGGCTTGTCCTCAGCGAGATCTACCCTGTGGAGATACGAGGAAGAGCCTTCGCCTTCTGCAACAGCTTCAACTGGGCGGCCA
ACCTCTTCATCAGCCTCTCCTTCCTCGATCTCATTGGCACCATCGGCTTGTCCTGGACCTTCCTGCTCTACGGACTGACCGCTGTCCTCG
GCCTGGGCTTCATCTATTTATTTGTTCCTGAAACAAAAGGCCAGTCGTTGGCAGAGATAGACCAGCAGTTCCAGAAGAGACGGTTCACCC
TGAGCTTTGGCCACAGGCAGAACTCCACTGGCATCCCGTACAGCCGCATCGAGATCTCTGCGGCCTCCTGAGGAATCCGTCTGCCTGGAA
ATTCTGGAACTGTGGCTTTGGCAGACCATCTCCAGCATCCTGCTTCCTAGGCCCCAGAGCACAAGTTCCAGCTGGTCTTTTGGGAGTGGC
CCCTGCCCCCAAAGGTGGTCTGCTTTTGCTGGGGTAAAAAGGATGAAAGTCTGAGAATGCCCAACTCTTCATTTTGAGTCTCAGGCCCTG
AAGGTTCCTGAGGATCTAGCTTCATGCCTCAGTTTCCCCATTGACTTGCACATCTCTGCAGTATTTATAAGAAGAATATTCTATGAAGTC
TTTGTTGCACCATGGACTTTTCTCAAAGAATCTCAAGGGTACCAATCCTGGCAGGAAGTCTCTCCCGATATCACCCCTAAATCCAAATGA
GGATATCATCTTTTCTAATCTCTTTTTTCAACTGGCTGGGACATTTTCGGAAGGGGGAAGTCTCTTTTTTTACTCTTATCATTTTTTTTT
TTTGAGGTGGAGTCTCATTCTGTTGCCCAGGCTGGCCTGATCTTGGCTCACTGCAACCTCCACCTCCTGAGTTCAAGCGATTCTTGTGCC
TCAGCCTCCTAAGCAGCTGGGACTACAGGCGCATGCAACCATACCCAGCTAATTTATTTTTAGCAGAGATGGGGTTTCACTGTGTTGGCC
AGGCTGGTCGTGAACTCCTGAGCTCAAGTGATCCACCCACCTCAGCCTCCCAGAGTGCTAGGATTACAGGCCTTTTGACTCTTTTATCTG
AGTTTTATTGACCCCTCTAATTCTCTTACCCAGAATATTTATCCTTCACCAGCAACTCTGACTCTTTGACGGGAGGCCTCAGTTCTAGTC
CTTGGTCTGCTGGTGTCATTGCTGTAGGAATGACCACGGGCCTCAGTTTCCCCATTTGTATAATGGGAAGCCTGTACCAGGTCATTCTTA
AGATTTCTCCTGACTCCAGTGAGCTGGAATTCTAAATGCTGGTCTAGGAGCTGTCTCCAGGATGGTGCAGGATGGCTTTGCGGAAAGGAG
ATGGGTTTGGAGGCCAACAAACCTGCTTGTCAATATTGCCTTTGCCTCTTGGCAGCCCTTGAACTTGAGTAAATAACAACTCCCTGAACC
TCAGTTTCCTCATCTGCAGAATGGGGATAATTATGTCCCAGGGGTATATTTAGACCCTGTTTCCTTTCAGGAGGGTCCCCAGCTGGTCCA
GGGCCTGGGAAATTTCTACTTATCCTCATTACCCAGGTCCCTCCTTTGGACCCTGTAAAGGGTCAGGGTGAATCAGATGGGGGACTGAGC
AAGTAGCTATGACTGCAGATCATGTAAGGAAGGGACTGACAAGAAGCTCCCAGATGCTGGGGAGAATGAAGAGCTAAAATAGATCCTAGG
TGCTGGATGCTTTGTCATCCATGCGTGCACATATGGGTGCTGGCAGAGCCCCCAAGGACTCTGGCCTCTCGAGTTCTCCTATCTTCTCCA
TTCTAGATGCTTCCCTTGTATCCAGTGATGTGCTGGAGCTGGCTTTGCCAAGCTTGTGAGAGCTGGTTGCTACATTTTCAGGATTTTTAC
AAGTTGGTAAACACAGCCATTATAAAAAATTAAATGATTTAAATTTATAATTAAGTAAATTACATTAAAACAAAAAAATTATACTCAAAA
TTCATTACTTAATTTTACTACCTGTTACTATTATCTGTGCTTTTGAGGCTATTTCTACATAGTAACTCTTATGGAGACCTAGGGGAGACA
CCGCGCATCTCTTCCTGATTCCCCACTCAATGACATCATGTTAGTCTTTGGTTGCTTAACTGGCTGTGGGGAGTGTTTTTGTATCACAAA
GATTAGAGAGGACTACACATCAGGGCTTGATTTATTGTTTGTTGATTTTCTAGACTTCAGAACATGCTGGATAAAATGTCAGTAATGCAA
ATTAAACTTTAAAGTATGTCTTGTTTGTAGCCAATACATGGTGTATAGCACCAAAAAATGGAGGGATTATTCTTCCAGTAGTTGAACACT
GTCATCCGTTTCAGCTGACAGCTGCTCAAATCATTTAAGAAGGAGTTCTGACATTCATTTTCATTGTTTTACTTTTGTCTTCCTCACTAG
TGTAAACAAAAATTTCAACCAGCATTCATGCCGAACCTATACCCATTCTTCAGTGCCTAGCTGTACAGTTATCAGGGATTTTTATTTGTA
GTCTAATTTTGTCAAATCATGGCCAAATCGCAGTGATAGTTGACTTTGGATACAAGGTTTGGCAAAAAAAAAAATATTAACAAAATATTC
TGTAAGAATCAATTGTCTATATGGAATTTAGGATAAAGAATATTTACAATAAAGAATATTTACAATAAAGAGTTTATTATTATTTGTAAG
TTGTGTGCAACAAACATACCCTTTATCTCTGTAAAATTTATACACACAAAAATTAACAAAAGATTCTGTAAGAATTAATTGGCTATATGG

>28052_28052_6_EYA2-SLC2A10_EYA2_chr20_45644936_ENST00000357410_SLC2A10_chr20_45353680_ENST00000359271_length(amino acids)=780AA_BP=240
MRPAAGCVRPRSPASRLGAPTRPRSGAGTRAGAEGGPGPGRRRGRSSRRRQQPRQPRRRRQRQRQRQQRARRSQPGLVGPAPARPPARTA
SGRPLHCARYKEMVELVISPSLTVNSDCLDKLKFNRADAAVWTLSDRQGITKSAPLRVSQLFSRSCPRVLPRQPSTAMAAYGQTQYSAGI
QQATPYTAYPPPAQAYGIPSYSIKTEDSLNHSPGQSGFLSYGSSFSTSPTGQSPYTYQMHGHSPPVLPLCASVSLLGGLTFGYELAVISG
ALLPLQLDFGLSCLEQEFLVGSLLLGALLASLVGGFLIDCYGRKQAILGSNLVLLAGSLTLGLAGSLAWLVLGRAVVGFAISLSSMACCI
YVSELVGPRQRGVLVSLYEAGITVGILLSYALNYALAGTPWGWRHMFGWATAPAVLQSLSLLFLPAGTDETATHKDLIPLQGGEAPKLGP
GRPRYSFLDLFRARDNMRGRTTVGLGLVLFQQLTGQPNVLCYASTIFSSVGFHGGSSAVLASVGLGAVKVAATLTAMGLVDRAGRRALLL
AGCALMALSVSGIGLVSFAVPMDSGPSCLAVPNATGQTGLPGDSGLLQDSSLPPIPRTNEDQREPILSTAKKTKPHPRSGDPSAPPRLAL
SSALPGPPLPARGHALLRWTALLCLMVFVSAFSFGFGPVTWLVLSEIYPVEIRGRAFAFCNSFNWAANLFISLSFLDLIGTIGLSWTFLL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for EYA2-SLC2A10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for EYA2-SLC2A10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for EYA2-SLC2A10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource