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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:EZH1-FOXK2 (FusionGDB2 ID:28092)

Fusion Gene Summary for EZH1-FOXK2

Fusion gene summary

Fusion gene information	Fusion gene name: EZH1-FOXK2
	Fusion gene ID: 28092
		Hgene	Tgene
	Gene symbol	EZH1	FOXK2
	Gene ID	2145	3607
	Gene name	enhancer of zeste 1 polycomb repressive complex 2 subunit	forkhead box K2
	Synonyms	KMT6B	ILF\|ILF-1\|ILF1\|nGTBP
	Cytomap	17q21.2	17q25.3
	Type of gene	protein-coding	protein-coding
	Description	histone-lysine N-methyltransferase EZH1ENX-2enhancer of zeste homolog 1	forkhead box protein K2FOXK1G/T-mismatch specific binding proteincellular transcription factor ILF-1interleukin enhancer-binding factor 1
	Modification date	20200315	20200313
	UniProtAcc	Q92800	Q01167
	Ensembl transtripts involved in fusion gene	ENST00000415827, ENST00000428826, ENST00000435174, ENST00000585893, ENST00000590078, ENST00000592743, ENST00000590783,	ENST00000529652, ENST00000335255,
Fusion gene scores	* DoF score	8 X 12 X 6=576	10 X 15 X 9=1350
	# samples	12	16
	** MAII score	log2(12/576*10)=-2.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(16/1350*10)=-3.07681559705083 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: EZH1 [Title/Abstract] AND FOXK2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	EZH1(40855757)-FOXK2(80543779), # samples:1
Anticipated loss of major functional domain due to fusion event.	EZH1-FOXK2 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF. EZH1-FOXK2 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. EZH1-FOXK2 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF. EZH1-FOXK2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. EZH1-FOXK2 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	FOXK2	GO:0045892	negative regulation of transcription, DNA-templated	20810654\|25451922
Tgene	FOXK2	GO:0045893	positive regulation of transcription, DNA-templated	22083952
Tgene	FOXK2	GO:0045944	positive regulation of transcription by RNA polymerase II	9065434

Fusion gene breakpoints across EZH1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across FOXK2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	ESCA	TCGA-LN-A9FO	EZH1	chr17	40855757	-	FOXK2	chr17	80543779	+

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Fusion Gene ORF analysis for EZH1-FOXK2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000415827	ENST00000529652	EZH1	chr17	40855757	-	FOXK2	chr17	80543779	+
5CDS-intron	ENST00000428826	ENST00000529652	EZH1	chr17	40855757	-	FOXK2	chr17	80543779	+
5CDS-intron	ENST00000435174	ENST00000529652	EZH1	chr17	40855757	-	FOXK2	chr17	80543779	+
5CDS-intron	ENST00000585893	ENST00000529652	EZH1	chr17	40855757	-	FOXK2	chr17	80543779	+
5CDS-intron	ENST00000590078	ENST00000529652	EZH1	chr17	40855757	-	FOXK2	chr17	80543779	+
5CDS-intron	ENST00000592743	ENST00000529652	EZH1	chr17	40855757	-	FOXK2	chr17	80543779	+
Frame-shift	ENST00000415827	ENST00000335255	EZH1	chr17	40855757	-	FOXK2	chr17	80543779	+
Frame-shift	ENST00000428826	ENST00000335255	EZH1	chr17	40855757	-	FOXK2	chr17	80543779	+
Frame-shift	ENST00000585893	ENST00000335255	EZH1	chr17	40855757	-	FOXK2	chr17	80543779	+
Frame-shift	ENST00000590078	ENST00000335255	EZH1	chr17	40855757	-	FOXK2	chr17	80543779	+
Frame-shift	ENST00000592743	ENST00000335255	EZH1	chr17	40855757	-	FOXK2	chr17	80543779	+
In-frame	ENST00000435174	ENST00000335255	EZH1	chr17	40855757	-	FOXK2	chr17	80543779	+
intron-3CDS	ENST00000590783	ENST00000335255	EZH1	chr17	40855757	-	FOXK2	chr17	80543779	+
intron-intron	ENST00000590783	ENST00000529652	EZH1	chr17	40855757	-	FOXK2	chr17	80543779	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000435174

EZH1

chr17

40855757

ENST00000335255

FOXK2

chr17

80543779

5814

2002

321

2705

794

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000435174	ENST00000335255	EZH1	chr17	40855757	-	FOXK2	chr17	80543779	+	0.00069242	0.99930763

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Fusion Genomic Features for EZH1-FOXK2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
EZH1	chr17	40855757	-	FOXK2	chr17	80543779	+	9.54E-08	0.9999999
EZH1	chr17	40855757	-	FOXK2	chr17	80543779	+	9.54E-08	0.9999999

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for EZH1-FOXK2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:40855757/chr17:80543779)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
EZH1 Q92800	FOXK2 Q01167
FUNCTION: Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH2-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. {ECO:0000269\|PubMed:19026781}.	FUNCTION: Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis and autophagy (By similarity). Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context (PubMed:22083952, PubMed:25451922). Together with FOXK1, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen (By similarity). Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4 (By similarity). Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate (By similarity). Together with FOXK1, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins (By similarity). In addition to the 5'-GTAAACA-3' DNA motif, also binds the 5'-TGANTCA-3' palindromic DNA motif, and co-associates with JUN/AP-1 to activate transcription (PubMed:22083952). Also able to bind to a minimal DNA heteroduplex containing a G/T-mismatch with 5'-TRT[G/T]NB-3' sequence (PubMed:20097901). Binds to NFAT-like motifs (purine-rich) in the IL2 promoter (PubMed:1339390). Positively regulates WNT/beta-catenin signaling by translocating DVL proteins into the nucleus (PubMed:25805136). Also binds to HIV-1 long terminal repeat. May be involved in both positive and negative regulation of important viral and cellular promoter elements (PubMed:1909027). {ECO:0000250\|UniProtKB:Q3UCQ1, ECO:0000269\|PubMed:1339390, ECO:0000269\|PubMed:1909027, ECO:0000269\|PubMed:20097901, ECO:0000269\|PubMed:22083952, ECO:0000269\|PubMed:25451922, ECO:0000269\|PubMed:25805136}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

EZH1

chr17:40855757

chr17:80543779

ENST00000428826

524_606

699

748.0

Compositional bias

Note=Cys-rich

Hgene

EZH1

chr17:40855757

chr17:80543779

ENST00000585893

524_606

659

708.0

Compositional bias

Note=Cys-rich

Hgene

EZH1

chr17:40855757

chr17:80543779

ENST00000590078

524_606

629

678.0

Compositional bias

Note=Cys-rich

Hgene

EZH1

chr17:40855757

chr17:80543779

ENST00000592743

524_606

699

748.0

Compositional bias

Note=Cys-rich

Hgene

EZH1

chr17:40855757

chr17:80543779

ENST00000428826

504_606

699

748.0

Domain

CXC

Hgene

EZH1

chr17:40855757

chr17:80543779

ENST00000585893

504_606

659

708.0

Domain

CXC

Hgene

EZH1

chr17:40855757

chr17:80543779

ENST00000590078

504_606

629

678.0

Domain

CXC

Hgene

EZH1

chr17:40855757

chr17:80543779

ENST00000592743

504_606

699

748.0

Domain

CXC

Hgene

EZH1

chr17:40855757

chr17:80543779

ENST00000428826

491_496

699

748.0

Motif

Nuclear localization signal

Hgene

EZH1

chr17:40855757

chr17:80543779

ENST00000435174

491_496

560

609.0

Motif

Nuclear localization signal

Hgene

EZH1

chr17:40855757

chr17:80543779

ENST00000585893

491_496

659

708.0

Motif

Nuclear localization signal

Hgene

EZH1

chr17:40855757

chr17:80543779

ENST00000590078

491_496

629

678.0

Motif

Nuclear localization signal

Hgene

EZH1

chr17:40855757

chr17:80543779

ENST00000592743

491_496

699

748.0

Motif

Nuclear localization signal

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

EZH1

chr17:40855757

chr17:80543779

ENST00000435174

524_606

560

609.0

Compositional bias

Note=Cys-rich

Hgene

EZH1

chr17:40855757

chr17:80543779

ENST00000428826

613_728

699

748.0

Domain

SET

Hgene

EZH1

chr17:40855757

chr17:80543779

ENST00000435174

504_606

560

609.0

Domain

CXC

Hgene

EZH1

chr17:40855757

chr17:80543779

ENST00000435174

613_728

560

609.0

Domain

SET

Hgene

EZH1

chr17:40855757

chr17:80543779

ENST00000585893

613_728

659

708.0

Domain

SET

Hgene

EZH1

chr17:40855757

chr17:80543779

ENST00000590078

613_728

629

678.0

Domain

SET

Hgene

EZH1

chr17:40855757

chr17:80543779

ENST00000592743

613_728

699

748.0

Domain

SET

Tgene

FOXK2

chr17:40855757

chr17:80543779

ENST00000335255

10_93

426

661.0

Compositional bias

Note=Gly-rich

Tgene

FOXK2

chr17:40855757

chr17:80543779

ENST00000335255

258_353

426

661.0

DNA binding

Fork-head

Tgene

FOXK2

chr17:40855757

chr17:80543779

ENST00000335255

54_128

426

661.0

Domain

FHA

Tgene

FOXK2

chr17:40855757

chr17:80543779

ENST00000335255

300_318

426

661.0

Region

DNA-binding%3B major groove

Tgene

FOXK2

chr17:40855757

chr17:80543779

ENST00000335255

328_332

426

661.0

Region

DNA-binding%3B minor groove

Tgene

FOXK2

chr17:40855757

chr17:80543779

ENST00000335255

348_353

426

661.0

Region

DNA-binding%3B minor groove

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Fusion Gene Sequence for EZH1-FOXK2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>28092_28092_1_EZH1-FOXK2_EZH1_chr17_40855757_ENST00000435174_FOXK2_chr17_80543779_ENST00000335255_length(transcript)=5814nt_BP=2002nt
GCGCATGCGTCCTAGCAGCGGGACCCGCGGCTCGGGATGGAGGCTGGACACCTGTTCTGCTGTTGTGTCCTGCCATTCTCCTGAAGAACA
GAGGCACACTGTAAAACCCAACACTTCCCCTTGCATTCTATAAGATTACAGCAAGATGGAAATACCAAATCCCCCTACCTCCAAATGTAT
CACTTACTGGAAAAGAAAAGTGAAATCTGAATACATGCGACTTCGACAACTTAAACGGCTTCAGGCAAATATGGGTGCAAAGGCTTTGTA
TGTGGCAAATTTTGCAAAGGTTCAAGAAAAAACCCAGATCCTCAATGAAGAATGGAAGAAGCTTCGTGTCCAACCTGTTCAGTCAATGAA
GCCTGTGAGTGGACACCCTTTTCTCAAAAAGAGATGATCCCTGGATCCGTTCTGATTAGTGATGCTGTTTTTCTGGAGTTGGTCGATGCC
CTGAATCAGTACTCAGATGAGGAGGAGGAAGGGCACAATGACACCTCAGATGGAAAGCAGGATGACAGCAAAGAAGATCTGCCAGTAACA
AGAAAGAGAAAGCGACATGCTATTGAAGGCAACAAAAAGAGTTCCAAGAAACAGTTCCCAAATGACATGATCTTCAGTGCAATTGCCTCA
ATGTTCCCTGAGAATGGTGTCCCAGATGACATGAAGGAGAGGTATCGAGAACTAACAGAGATGTCAGACCCCAATGCACTTCCCCCTCAG
TGCACACCCAACATCGATGGCCCCAATGCCAAGTCTGTGCAGCGGGAGCAATCTCTGCACTCCTTCCACACACTTTTTTGCCGGCGCTGC
TTTAAATACGACTGCTTCCTTCACCCTTTTCATGCCACCCCTAATGTATATAAACGCAAGAATAAAGAAATCAAGATTGAACCAGAACCA
TGTGGCACAGACTGCTTCCTTTTGCTGGAAGGAGCAAAGGAGTATGCCATGCTCCACAACCCCCGCTCCAAGTGCTCTGGTCGTCGCCGG
AGAAGGCACCACATAGTCAGTGCTTCCTGCTCCAATGCCTCAGCCTCTGCTGTGGCTGAGACTAAAGAAGGAGACAGTGACAGGGACACA
GGCAATGACTGGGCCTCCAGTTCTTCAGAGGCTAACTCTCGCTGTCAGACTCCCACAAAACAGAAGGCTAGTCCAGCCCCACCTCAACTC
TGCGTAGTGGAAGCACCCTCGGAGCCTGTGGAATGGACTGGGGCTGAAGAATCTCTTTTTCGAGTCTTCCATGGCACCTACTTCAACAAC
TTCTGTTCAATAGCCAGGCTTCTGGGGACCAAGACGTGCAAGCAGGTCTTTCAGTTTGCAGTCAAAGAATCACTTATCCTGAAGCTGCCA
ACAGATGAGCTCATGAACCCCTCACAGAAGAAGAAAAGAAAGCACAGATTGTGGGCTGCACACTGCAGGAAGATTCAGCTGAAGAAAGAT
AACTCTTCCACACAAGTGTACAACTACCAACCCTGCGACCACCCAGACCGCCCCTGTGACAGCACCTGCCCCTGCATCATGACTCAGAAT
TTCTGTGAGAAGTTCTGCCAGTGCAACCCAGACTGTCAGAATCGTTTCCCTGGCTGTCGCTGTAAGACCCAGTGCAATACCAAGCAATGT
CCTTGCTATCTGGCAGTGCGAGAATGTGACCCTGACCTGTGTCTCACCTGTGGGGCCTCAGAGCACTGGGACTGCAAGGTGGTTTCCTGT
AAAAACTGCAGCATCCAGCGTGGACTTAAGAAGCACCTGCTGCTGGCCCCCTCTGATGTGGCCGGATGGGGCACCTTCATAAAGGAGTCT
GTGCAGAAGAACGAATTCATTTCTGAATACTGTGGTGAGCTCATCTCTCAGGATGAGGCTGATCGACGCGGAAAGGTCTATGACAAATAC
ATGTCCAGCTTCCTCTTCAACCTCAATAATGATTTTGTAGTGGATGCTACTCGGAAAGGAAACAAAATTCGATTTGCAAATCATTCAGTG
AATCCCAACTGTTATGCCAAAGGGTCACCTCTGTCCAGTCAGCCAGTCTTAATCACCGTCCAGCGGCAGCTACCACAGGCCATCAAGCCT
GTCACCTACACTGTGGCCACCCCAGTGACCACCTCGACCTCCCAGCCACCCGTCGTGCAGACGGTTCACGTCGTCCACCAGATCCCAGCG
GTGTCGGTCACCAGTGTGGCCGGACTGGCCCCAGCGAACACGTACACTGTCTCTGGACAAGCTGTGGTCACCCCGGCAGCCGTGCTGGCC
CCTCCTAAGGCAGAGGCCCAGGAGAATGGAGACCACAGGGAAGTCAAAGTGAAAGTAGAGCCTATTCCCGCCATTGGCCACGCCACGCTC
GGCACTGCCAGCCGGATCATTCAGACGGCACAGACCACCCCGGTCCAGACGGTGACCATAGTACAACAGGCACCTCTAGGTCAACACCAG
CTACCAATAAAAACTGTAACACAAAACGGCACTCACGTGGCATCAGTCCCCACTGCGGTCCACGGCCAGGTGAACAATGCCGCGGCGAGT
CCTTTGCACATGTTGGCAACACACGCATCCGCATCGGCCTCCCTGCCCACAAAGCGCCACAACGGTGACCAGCCGGAGCAGCCGGAGCTG
AAGCGGATCAAGACAGAAGACGGCGAGGGCATCGTCATTGCCCTGAGCGTGGACACGCCACCGGCAGCCGTAAGGGAAAAGGGTGTCCAG
AACTAGCGACCGGGAGAGCTTTTCTTTAACGATATCAACTCTGTGGTGCCAAAAGGAGACGCGGCCTCCCGCCAGCACTCGGGGGTGCAG
GGCCCTGTGGTTGGACTTCACCTCTCAGCACTGAAAACCCAAAACCCAGCTGGCCTTAACACTCCTTAAAGACAGAAGTCACACTTGAAC
AAAACCCACACACAACAAAACCTGATTTGGGAGACGGTGTCTCCACTGAGCACCTGCTGGGCTGAGCTTCTACCTACGAGTGAAACTCTG
TCCTCCCGCGAGGACCAGGCATCGCTGTGTGAGGACGGCACGGCCAGCGCCTGCTGTGAGTGGGTCTCCCAAGACTAGGCCTCAGGACGC
GGGGGGAGCCATCCCCGCCGCCCTCACAGGACCCACCAGGCAGCGGAGACATGTGGAATTAGAGTATTTTGAGGTGTCCTTTCTTTACAA
AATAATGGGGTCTTGGGCATTTCACATCACTCCATTTCTACTGAGACTTTCAGAATCACACAGGCCCTTTCCGTGGATTTCATTTGGGGC
AAAGAAACAACGTAGTTTTGTTTTTGTTTTCAGCCTATGGAATGATTTCCTTTTGTCTGTCTTGTTCAAGTTCAGACGAAGCTACTCTGG
CATCTGCACATTTCCGTGTTACAGCAGCTGCCTGATGAATTTTATCCACCTCCATTTCAGCATGTGGCTCGCGTGGACAGGTGGACGGAC
GCTGTGGCCGCATGGAACCTTGAGAACCCAGGGACGAGCCAGTGCCGGGAAGGAACTGCCGGGACTCACCGAGCTGCACTTAACTGTTCT
CTTTCTGGCTATTTTTTGTTGTTTGTTTCTTTGTGTTGACTTTGTCCCTGGCAAAATTTTCCACTCTGAGTAAAACAAGTCTCCTAAGTA
TTGTGTATGTTTAAAACGACAGAACCATTTCTACTTCATTTGGAAAAAGATTCAGTCTTTTATCACAGGCCCTTTTGAAACTCAGATCCC
AGGTCTCTCCGTGGTATGTTTGTATTTGGGGTGTCCCTCCGGCTCTAGGCGGCCTCTGACCTGCTGTCTACTCCCCACCTTCGGTGAGCG
GCCGCCATGGTGGAGCAGGGTCCGAGCCACGTCCTGCAGGGCACGTCTGGGGCATTTCCTGTTTTGTGGTAGGAAATGTCCCTGACCTTT
CAGAACCGAACCCAATCCTGAGGCTGACTCCTCTACGGAAAATGAGGACAGGACGGGGGTGAGGGAATGAGAGTGGGAGGTCCCTGCACC
TCCTCGCCCGGCTCCTCAGGAAGAAAACCGCTGGCCCTTCCCGAGTGTGCCGGCCGAGGGCCGAGGGCCGTGCACATGGGGAGAGGGCGT
CAGCCTGATGGCTGAGCTTTTAAATGTCATCATCATAACATTATTTATTTAAATGTAGTTATTTTGGTATTTAATTTTTTTTTAGAGAGG
AAAAAACCTGTATTTTCCTGGTGGGATGAAATAGGGATGAAATGGCTCAGAATGGTATATTTAGGCAATTTTAAAACATTTATTATTTAC
ATAAAGACCAAATATGATGAATCTGTTCCGTGAATTGTGTCGGCCCTCAGCATGGGGCTGGGGCAGCGTCACTGCGGTGACGCCCATTGA
AAGGTATGAAATGACTGCACACTAGCTGGATTATCACTCAGCCGTTTAAGAAATAAAAGCAAAACCATCACGTGACTGAGACCGTGTGTG
TGACCGCAGCAAAGCGCAGCGTGTGGATGGATCAGAGCCCCTCGGTGCAGCTGTCTGCATCTTCCAAGCACTTTACAGATACCTTGGAAT
GTATATTTTTGTCTTCTTACTCAGAAGGTTTGCAGTTTGTAAAATAATCAGGATTCTGCTCTGTCCTGTGTGTGGGGTCAGCTCCCTCCA
CAGAGGGCTCCAGCTCTGTTGGTCACAGCTGATGGGGTTCTCTGATTGATAGGAGACGAGCTCTTGAGCTCTAAGGAACAGTGAGGTCGC
CGGTGGGGAGCTTGGCTGGGACACCAAGCAAATGCATCGTATGTCCCCTTGGAGACGTTTTTATGCAGCTGTGTATGTTACTATCCAGAA
GGAGTCGGGGGTAGACTTTCCCGTGTAAGCTCAGTCCATAAACTGGTTACTTCTGATCCTGGAACGTGGACTTCACATGATAGGTCTGGA
TCTGTTTCTGTTGGGATCACAGGTAAGGAAAATGTCCATTCAAATGGTAAAGAAGGGAGGAGGGTGTTTTTTTTTTTTTTTTTTGCCGTA
GGCACCATTCTGCATCTTGAACCCAGACTGAAGTGTGCCTCTCACAGATGGAAGGTGCACACGCTCCTGTCTCCTCCTCACTCTGCCACG
TTCACTTGGCTTTTTCATTGGTACCTAGGAATTTAAGAATATCGAAGCGAGAGCAGTAACAAACCATAGATGAGCAGACTCCCACACCGG
GTTTTCTTGCCCGTCTTTAAGGCACTGTTTCTAAATTTTGAACTTAGCTCTGAATCCCCAAGAACTTGAGCACAGCAAGGGTTGCTGAGC
TGCTGTCGCCGCAGCCCTGGCCCCTGGTGCTGGAGCTGCAGCACCTTTGGGAGAGGTCCTGCGTCGTCCTCAGCTGCGTCGCTGTGAACT
CCCGCTCTCCACTGTGTTCCTCAGTGTCTGCTTTTCAGGAAGTCTGCTGTGACCTTTGCCCAACTTCTGAGCTCCTCAGGGACTAGGAAC
AATTTCAGTAGCTTTGCCCTGAACCAAACGAGAAAACAAAAGGGAACTCCCGTATGACCCACGTCACGTGGTGCACTCAGAGTGTGTGCG
GCATGATCCTCGGTTGCTCCTCCTCTCACTTTAGTAGAGTACGCGGTGGACAGCTGATCTCCTTCAGTCGTCTACCCACTTCCGTCATTG
TCCTCCGCTAGAATAACAGAGTAGTTGGTAGTCATGGCCAGAAGGGGGGTGGGGGCAGTGTGAGGACTTGGGGTTTCTGTGCTGTGTGAC
ACAAGGAGATAAGTGACAATCTTGAAGTCCTAACTTCCACTATTCTAGAAAGTATAGTGGTGATTTGTGTGCAAAGATTTGAAGTTTTAA

>28092_28092_1_EZH1-FOXK2_EZH1_chr17_40855757_ENST00000435174_FOXK2_chr17_80543779_ENST00000335255_length(amino acids)=794AA_BP=560
MEEASCPTCSVNEACEWTPFSQKEMIPGSVLISDAVFLELVDALNQYSDEEEEGHNDTSDGKQDDSKEDLPVTRKRKRHAIEGNKKSSKK
QFPNDMIFSAIASMFPENGVPDDMKERYRELTEMSDPNALPPQCTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLHPFHATPNVY
KRKNKEIKIEPEPCGTDCFLLLEGAKEYAMLHNPRSKCSGRRRRRHHIVSASCSNASASAVAETKEGDSDRDTGNDWASSSSEANSRCQT
PTKQKASPAPPQLCVVEAPSEPVEWTGAEESLFRVFHGTYFNNFCSIARLLGTKTCKQVFQFAVKESLILKLPTDELMNPSQKKKRKHRL
WAAHCRKIQLKKDNSSTQVYNYQPCDHPDRPCDSTCPCIMTQNFCEKFCQCNPDCQNRFPGCRCKTQCNTKQCPCYLAVRECDPDLCLTC
GASEHWDCKVVSCKNCSIQRGLKKHLLLAPSDVAGWGTFIKESVQKNEFISEYCGELISQDEADRRGKVYDKYMSSFLFNLNNDFVVDAT
RKGNKIRFANHSVNPNCYAKGSPLSSQPVLITVQRQLPQAIKPVTYTVATPVTTSTSQPPVVQTVHVVHQIPAVSVTSVAGLAPANTYTV
SGQAVVTPAAVLAPPKAEAQENGDHREVKVKVEPIPAIGHATLGTASRIIQTAQTTPVQTVTIVQQAPLGQHQLPIKTVTQNGTHVASVP

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Fusion Gene PPI Analysis for EZH1-FOXK2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for EZH1-FOXK2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for EZH1-FOXK2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source