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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:EZH1-IGFBP5 (FusionGDB2 ID:28093) |
Fusion Gene Summary for EZH1-IGFBP5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: EZH1-IGFBP5 | Fusion gene ID: 28093 | Hgene | Tgene | Gene symbol | EZH1 | IGFBP5 | Gene ID | 2145 | 3488 |
| Gene name | enhancer of zeste 1 polycomb repressive complex 2 subunit | insulin like growth factor binding protein 5 | |
| Synonyms | KMT6B | IBP5 | |
| Cytomap | 17q21.2 | 2q35 | |
| Type of gene | protein-coding | protein-coding | |
| Description | histone-lysine N-methyltransferase EZH1ENX-2enhancer of zeste homolog 1 | insulin-like growth factor-binding protein 5IBP-5IGF-binding protein 5IGFBP-5 | |
| Modification date | 20200315 | 20200313 | |
| UniProtAcc | Q92800 | P24593 | |
| Ensembl transtripts involved in fusion gene | ENST00000428826, ENST00000585893, ENST00000435174, ENST00000590078, ENST00000592743, ENST00000415827, ENST00000590783, | ENST00000233813, | |
| Fusion gene scores | * DoF score | 8 X 12 X 6=576 | 15 X 20 X 2=600 |
| # samples | 12 | 20 | |
| ** MAII score | log2(12/576*10)=-2.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(20/600*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: EZH1 [Title/Abstract] AND IGFBP5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | EZH1(40879653)-IGFBP5(217543802), # samples:3 | ||
| Anticipated loss of major functional domain due to fusion event. | EZH1-IGFBP5 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF. EZH1-IGFBP5 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. EZH1-IGFBP5 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF. EZH1-IGFBP5 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. EZH1-IGFBP5 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | IGFBP5 | GO:0014912 | negative regulation of smooth muscle cell migration | 10766744 |
| Tgene | IGFBP5 | GO:0017148 | negative regulation of translation | 15700281 |
| Tgene | IGFBP5 | GO:0030336 | negative regulation of cell migration | 15700281 |
| Tgene | IGFBP5 | GO:0043569 | negative regulation of insulin-like growth factor receptor signaling pathway | 10766744 |
| Tgene | IGFBP5 | GO:0048662 | negative regulation of smooth muscle cell proliferation | 10766744 |
| Tgene | IGFBP5 | GO:0071320 | cellular response to cAMP | 7559606 |
| Tgene | IGFBP5 | GO:0071407 | cellular response to organic cyclic compound | 7559606 |
| Fusion gene breakpoints across EZH1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across IGFBP5 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | PRAD | TCGA-XQ-A8TA-01A | EZH1 | chr17 | 40879653 | - | IGFBP5 | chr2 | 217543802 | - |
| ChimerDB4 | PRAD | TCGA-XQ-A8TA | EZH1 | chr17 | 40879653 | - | IGFBP5 | chr2 | 217543802 | - |
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Fusion Gene ORF analysis for EZH1-IGFBP5 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000428826 | ENST00000233813 | EZH1 | chr17 | 40879653 | - | IGFBP5 | chr2 | 217543802 | - |
| Frame-shift | ENST00000585893 | ENST00000233813 | EZH1 | chr17 | 40879653 | - | IGFBP5 | chr2 | 217543802 | - |
| In-frame | ENST00000435174 | ENST00000233813 | EZH1 | chr17 | 40879653 | - | IGFBP5 | chr2 | 217543802 | - |
| In-frame | ENST00000590078 | ENST00000233813 | EZH1 | chr17 | 40879653 | - | IGFBP5 | chr2 | 217543802 | - |
| In-frame | ENST00000592743 | ENST00000233813 | EZH1 | chr17 | 40879653 | - | IGFBP5 | chr2 | 217543802 | - |
| intron-3CDS | ENST00000415827 | ENST00000233813 | EZH1 | chr17 | 40879653 | - | IGFBP5 | chr2 | 217543802 | - |
| intron-3CDS | ENST00000590783 | ENST00000233813 | EZH1 | chr17 | 40879653 | - | IGFBP5 | chr2 | 217543802 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000435174 | EZH1 | chr17 | 40879653 | - | ENST00000233813 | IGFBP5 | chr2 | 217543802 | - | 5519 | 391 | 321 | 872 | 183 |
| ENST00000592743 | EZH1 | chr17 | 40879653 | - | ENST00000233813 | IGFBP5 | chr2 | 217543802 | - | 5424 | 296 | 226 | 777 | 183 |
| ENST00000590078 | EZH1 | chr17 | 40879653 | - | ENST00000233813 | IGFBP5 | chr2 | 217543802 | - | 5375 | 247 | 177 | 728 | 183 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000435174 | ENST00000233813 | EZH1 | chr17 | 40879653 | - | IGFBP5 | chr2 | 217543802 | - | 0.00842821 | 0.9915718 |
| ENST00000592743 | ENST00000233813 | EZH1 | chr17 | 40879653 | - | IGFBP5 | chr2 | 217543802 | - | 0.008499922 | 0.9915001 |
| ENST00000590078 | ENST00000233813 | EZH1 | chr17 | 40879653 | - | IGFBP5 | chr2 | 217543802 | - | 0.008432284 | 0.9915677 |
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Fusion Genomic Features for EZH1-IGFBP5 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for EZH1-IGFBP5 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:40879653/chr2:217543802) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| EZH1 | IGFBP5 |
| FUNCTION: Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH2-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. {ECO:0000269|PubMed:19026781}. | FUNCTION: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | IGFBP5 | chr17:40879653 | chr2:217543802 | ENST00000233813 | 0 | 4 | 189_263 | 112 | 273.0 | Domain | Thyroglobulin type-1 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | EZH1 | chr17:40879653 | chr2:217543802 | ENST00000428826 | - | 4 | 21 | 524_606 | 82 | 748.0 | Compositional bias | Note=Cys-rich |
| Hgene | EZH1 | chr17:40879653 | chr2:217543802 | ENST00000435174 | - | 4 | 19 | 524_606 | 23 | 609.0 | Compositional bias | Note=Cys-rich |
| Hgene | EZH1 | chr17:40879653 | chr2:217543802 | ENST00000585893 | - | 4 | 20 | 524_606 | 82 | 708.0 | Compositional bias | Note=Cys-rich |
| Hgene | EZH1 | chr17:40879653 | chr2:217543802 | ENST00000590078 | - | 3 | 20 | 524_606 | 12 | 678.0 | Compositional bias | Note=Cys-rich |
| Hgene | EZH1 | chr17:40879653 | chr2:217543802 | ENST00000592743 | - | 3 | 20 | 524_606 | 82 | 748.0 | Compositional bias | Note=Cys-rich |
| Hgene | EZH1 | chr17:40879653 | chr2:217543802 | ENST00000428826 | - | 4 | 21 | 504_606 | 82 | 748.0 | Domain | CXC |
| Hgene | EZH1 | chr17:40879653 | chr2:217543802 | ENST00000428826 | - | 4 | 21 | 613_728 | 82 | 748.0 | Domain | SET |
| Hgene | EZH1 | chr17:40879653 | chr2:217543802 | ENST00000435174 | - | 4 | 19 | 504_606 | 23 | 609.0 | Domain | CXC |
| Hgene | EZH1 | chr17:40879653 | chr2:217543802 | ENST00000435174 | - | 4 | 19 | 613_728 | 23 | 609.0 | Domain | SET |
| Hgene | EZH1 | chr17:40879653 | chr2:217543802 | ENST00000585893 | - | 4 | 20 | 504_606 | 82 | 708.0 | Domain | CXC |
| Hgene | EZH1 | chr17:40879653 | chr2:217543802 | ENST00000585893 | - | 4 | 20 | 613_728 | 82 | 708.0 | Domain | SET |
| Hgene | EZH1 | chr17:40879653 | chr2:217543802 | ENST00000590078 | - | 3 | 20 | 504_606 | 12 | 678.0 | Domain | CXC |
| Hgene | EZH1 | chr17:40879653 | chr2:217543802 | ENST00000590078 | - | 3 | 20 | 613_728 | 12 | 678.0 | Domain | SET |
| Hgene | EZH1 | chr17:40879653 | chr2:217543802 | ENST00000592743 | - | 3 | 20 | 504_606 | 82 | 748.0 | Domain | CXC |
| Hgene | EZH1 | chr17:40879653 | chr2:217543802 | ENST00000592743 | - | 3 | 20 | 613_728 | 82 | 748.0 | Domain | SET |
| Hgene | EZH1 | chr17:40879653 | chr2:217543802 | ENST00000428826 | - | 4 | 21 | 491_496 | 82 | 748.0 | Motif | Nuclear localization signal |
| Hgene | EZH1 | chr17:40879653 | chr2:217543802 | ENST00000435174 | - | 4 | 19 | 491_496 | 23 | 609.0 | Motif | Nuclear localization signal |
| Hgene | EZH1 | chr17:40879653 | chr2:217543802 | ENST00000585893 | - | 4 | 20 | 491_496 | 82 | 708.0 | Motif | Nuclear localization signal |
| Hgene | EZH1 | chr17:40879653 | chr2:217543802 | ENST00000590078 | - | 3 | 20 | 491_496 | 12 | 678.0 | Motif | Nuclear localization signal |
| Hgene | EZH1 | chr17:40879653 | chr2:217543802 | ENST00000592743 | - | 3 | 20 | 491_496 | 82 | 748.0 | Motif | Nuclear localization signal |
| Tgene | IGFBP5 | chr17:40879653 | chr2:217543802 | ENST00000233813 | 0 | 4 | 23_103 | 112 | 273.0 | Domain | IGFBP N-terminal |
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Fusion Gene Sequence for EZH1-IGFBP5 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >28093_28093_1_EZH1-IGFBP5_EZH1_chr17_40879653_ENST00000435174_IGFBP5_chr2_217543802_ENST00000233813_length(transcript)=5519nt_BP=391nt GCGCATGCGTCCTAGCAGCGGGACCCGCGGCTCGGGATGGAGGCTGGACACCTGTTCTGCTGTTGTGTCCTGCCATTCTCCTGAAGAACA GAGGCACACTGTAAAACCCAACACTTCCCCTTGCATTCTATAAGATTACAGCAAGATGGAAATACCAAATCCCCCTACCTCCAAATGTAT CACTTACTGGAAAAGAAAAGTGAAATCTGAATACATGCGACTTCGACAACTTAAACGGCTTCAGGCAAATATGGGTGCAAAGGCTTTGTA TGTGGCAAATTTTGCAAAGGTTCAAGAAAAAACCCAGATCCTCAATGAAGAATGGAAGAAGCTTCGTGTCCAACCTGTTCAGTCAATGAA GCCTGTGAGTGGACACCCTTTTCTCAAAAAGAGAGAGACTCCCGTGAGCACGAGGAGCCCACCACCTCTGAGATGGCCGAGGAGACCTAC TCCCCCAAGATCTTCCGGCCCAAACACACCCGCATCTCCGAGCTGAAGGCTGAAGCAGTGAAGAAGGACCGCAGAAAGAAGCTGACCCAG TCCAAGTTTGTCGGGGGAGCCGAGAACACTGCCCACCCCCGGATCATCTCTGCACCTGAGATGAGACAGGAGTCTGAGCAGGGCCCCTGC CGCAGACACATGGAGGCTTCCCTGCAGGAGCTCAAAGCCAGCCCACGCATGGTGCCCCGTGCTGTGTACCTGCCCAATTGTGACCGCAAA GGATTCTACAAGAGAAAGCAGTGCAAACCTTCCCGTGGCCGCAAACGTGGCATCTGCTGGTGCGTGGACAAGTACGGGATGAAGCTGCCA GGCATGGAGTACGTTGACGGGGACTTTCAGTGCCACACCTTCGACAGCAGCAACGTTGAGTGATGCGTCCCCCCCCAACCTTTCCCTCAC CCCCTCCCACCCCCAGCCCCGACTCCAGCCAGCGCCTCCCTCCACCCCAGGACGCCACTCATTTCATCTCATTTAAGGGAAAAATATATA TCTATCTATTTGAGGAAACTGAGGACCTCGGAATCTCTAGCAAGGGCTCAACTTCGAAAATGGCAACAACAGAGATGCAAAAAGCTAAAA AGACACCCCCCCCCTTTAAATGGTTTTCTTTTTGAGGCAAGTTGGATGAACAGAGAAGGGAAGAGAGGAAGAACGAGAGGAAGAGAAGGG AAGGAAGTGTTTGTGTAGAAGAGAGAGAAAGACGAATAGAGTTAGGAAAAGGAAGACAAGCAGGTGGGCAGGAAGGACATGCACCGAGAC CAGGCAGGGGCCCAACTTTCACGTCCAGCCCTGGCCTGGGGTCGGGAGAGGTGGGCGCTAGAAGATGCAGCCCAGGATGTGGCAATCAAT GACACTATTGGGGTTTCCCAGGATGGATTGGTCAGGGGGAGAAAGGAAAAGGCAAAACACTCCAGGACCTCTCCCGGATCTGTCTCCTCC TCTAGCCAGCAGTATGGACAGCTGGACCCCTGAACTTCCTCTCCTCTTACCTGGGCAGAGTGTTGTCTCTCCCCAAATTTATAAAAACTA AAATGCATTCCATTCCTCTGAAAGCAAAACAAATTCATAATTGAGTGATATTAAATAGAGAGGTTTTCGGAAGCAGATCTGTGAATATGA AATACATGTGCATATTTCATTCCCCAGGCAGACATTTTTTAGAAATCAATACATGCCCCAATATTGGAAAGACTTGTTCTTCCACGGTGA CTACAGTACATGCTGAAGCGTGCCGTTTCAGCCCTCATTTAATTCAATTTGTAAGTAGCGCAGCAGCCTCTGTGGGGGAGGATAGGCTGA AAAAAAAAAGTGGGCTCGTATTTATCTACAGGACTCCATATAGTCATATATAGGCATATAAATCTATTCTTTTTCTTTGTTTTTTTCTTT CTTCCTTTCTTTCAAAGGTTTGCATTAACTTTTCAAAGTAGTTCCTATAGGGGCATTGAGGAGCTTCCTCATTCTGGGAAAACTGAGAAA ACCCATATTCTCCTAATACAACCCGTAATAGCATTTTTGCCTGCCTCGAGGCAGAGTTTCCCGTGAGCAATAAACTCAGCTTTTTTGTGG GGCACAGTACTGGATTTGACAGTGATTCCCCACGTGTGTTCATCTGCACCCACCGAGCCAGGCAGAGGCCAGCCCTCCGTGGTGCACACA GCACGCGCCTCAGTCCATCCCATTTTAGTCTTTAAACCCTCAGGAAGTCACAGTCTCCGGACACCACACCACATGAGCCCAACAGGTCCA CGATGGATCCACCAGTCCCACCCCAGCCTTTTCCTTTCATCTGAACAGAATGTGCATTTTTGGAAGCCTCCCTCACTCTCCATGCTGGCA GAGCAGGAGGGAGACTGAAGTAAGAGATGGCAGAGGGAGATGGTGGCAAAAAGGTTTAGATGCAGGAGAACAGTAAGATGGATGGTTCCG GCCAGAGTCGATGTGGGGAGGAACAGAGGGCTGAAGGGAGAGGGGGCTGACTGTTCCATTCTAGCTTTGGCACAAAGCAGCAGAAAGGGG GAAAAGCCAATAGAAATTTCCTTAGCTTCCCCACCATATGTATTTTCTAGGATTTGAGAGGAAAGAGAGGAAAATGGGGGAATGGGTTGC AAAATAGAAATGAGCTTAATCCAGGCCGCAGAGCCAGGGAAGGTGAGTAACTTTAGGAGGGTGCTAGACTTTAGAAGCCAGATAGGAAGA ATCAGTCTAAACTGGCCATGCTTTGGAAGGGACAAGACTATGTGCTCCGCTGCCCACCTTCAGCCTGCAATGAGGGACTGAGGCCCACGA GTCTTTCCAGCTCTTCCTCCATTCTGGCCAGTCCCTGCATCCTCCCTGGGGTGGAGGATGGAAGGAAAGCTGGGACAAGCAGGGAACGCA TGATTCAGGGATGCTGTCACTCGGCAGCCAGATTCCGAAACTCCCATTCTCCAATGACTTCCTCAACCAATGGGTGGCCTTGTGACTGTT CTTTAAGGCTGAAGATATCCAGGAAAGGGGGCTTGGACACTGGCCAAGGAGACCCCTTCGTGCTGTGGACACAGCTCTCTTCACTCTTTG CTCATGGCATGACACAGCGGAGACCGCCTCCAACAACGAATTTGGGGCTACGAAGAGGAATAGCGAAAAAGCAAATCTGTTTCAACTGAT GGGAACCCTATAGCTATAGAACTTGGGGGCTATCTCCTATGCCCCTGGACAGGACAGTTGGCTGGGGACAGGAGAAGTGCTCAATCTTCA TGAGACAAAGGGGCCCGATAGGGCCAGCAGCCACAAGGCCTTGACCTGCCGAGTCAGCATGCCCCATCTCTCTGCACAGCTGTCCCCTAA ACCCAACTCACGTTTCTGTATGTCTTAGGCCAGTATCCCAAACCTCTTCCACGTCACTGTTCTTTCCACCCATTCTCCCTTTGCATCTTG AGCAGTTATCCAACTAGGATCTGCCAAGTGGATACTGGGGTGCCACTCCCCTGAGAAAAGACTGAGCCAGGAACTACAAGCTCCCCCCAC ATTCCTCCCAGCCTGGACCTAATTCTTGAGAGGGGCTCTCTCTTCACGGACTGTGTCTGGACTTTGAGCAGGCTTCTGCCCCTTGCGTTG GCTCTTTGCTGCCAGCCATCAGGTGGGGGATTAGAGCCTGGTGTAAGTGCGCCAGACTCTTCCGGTTTCCAAAGTTCGTGCCTGCGAACC CAAACCTGTGAGTCTCTTCTGCATGCAGGAGTTTCTCCTGGGCAGCTGGTCACTCCCCAGAGAAGCTGGGCCTTCATGGACACATGGAAC TAAGCCTCCCAAATGGGAGTTCTGGCTGAGCCCAGGGTGGGGAGATCCTGGGAAGGGAGGCACTGGAGGAAGACGGCACCTCTTCCCCCA TGGCAGGGTGTGAGGGAGGCAGGTTTGGAATGGTGCGAGTATGGCAATCTAAGCAGGGGTCTGGTCTCTTTGACTCCAGGCTGGCCTTTG GCCGACTGTCTGCTCACCCAGAGACCTTGGACTCCGGACTATCCATGGCTCCGAATCTAAGTGCTGCCCACTCCCATGCTCACACCCACA GAAGGTCTTCCCATCCCCTTTAGATTCGTGCCTCACTCCACCAGTGAGGAAGATGCCTCTGTCTTTCCCACGACTGCCAGGAGATAGGGA AGCCCAGCCAGGACTGACCCTCCTTCCTCCAGCCTGCCCTGACCCACCTGGCAAAGCAGGGCACATGGGGAGGAAGAGACTGGAACCTTT CTTTGACAGCCAGGCCTAGACAGACAGGCCTGGGGACACTGGCCCCATGAGGGGAGGAAGGCAGGCGCACGAGGTCCAGGGAGGCCCTTT TCTGATCATGCCCCTTCTCTCCCACCCCATCTCCCCACCACCACCTCTGTGGCCTCCATGGTACCCCCACAGGGCTGGCCTCCCCTAGAG GGTGGGCCTCAACCACCTGCTCCCGCCACGCACCGGTTAGTGAGACAGGGCTGCCACGGCAACCGCCAAGCCCCCCTCAAGGTGGGACAG TACCCCGGACCCATCCACTCACTCCTGAGAGGGCTCCGGCCCAGAATGGGAACCTCAGAGAAGAGCTCTAAGGAGAAGAAACCCCATAGC GTCAGAGAGGATATGTCTGGCTTCCAAGAGAAAGGAGGCTCCGTTTTGCAAAGTGGAGGAGGGACGAGGGACAGGGGTTTCACCAGCCAG CAACCTGGGCCTTGTACTGTCTGTGTTTTTAAAACCACTAAAGTGCAAGAATTACATTGCACTGTTTCTCCACTTTTTATTTTCTCTTAG GCTTTTGTTTCTATTTCAAACATACTTTCTTGGTTTTCTAATGGAGTATATAGTTTAGTCATTTCACAGACTCTGGCCTCCTCTCCTGAA ATCCTTTTGGATGGGGAAAGGGAAGGTGGGGAGGGTCCGAGGGGAAGGGGACCCCAGCTTCCCTGTGCCCGCTCACCCCACTCCACCAGT CCCCGGTCGCCAGCCGGAGTCTCCTCTCTACCGCCACTGTCACACCGTAGCCCACATGGATAGCACAGTTGTCAGACAAGATTCCTTCAG ATTCCGAGTTGCCTACCGGTTGTTTTCGTTGTTGTTGTTGTTGTTTTTCTTTTTCTTTTTTTTTTTGAAGACAGCAATAACCACAGTACA TATTACTGTAGTTCTCTATAGTTTTACATACATTCATACCATAACTCTGTTCTCTCCTCTTTTTTGTTTTCAACTTTAAAAACAAAAATA AACGATGATAATCTTTACTGGTGAAAAGGATGGAAAAATAAATCAACAAATGCAACCAGTTTGTGAGAAAAAAAAAAAAAAGCCGAAAAA AAAAAAAAAAACACCTGAATGCGGAAGAGCTCGGCTCCCGTTTAGCATTTTGTACTTAAGGAAATAAAAAACCAACAAAGGATCTCACAT TTTCTTAAAAAGTGAAGATTGCTGTATACTATTTATTCAACTTATAATTTATGTTACTCCTTGATCTTTGTCTTTTGTCATGACAAAGCA >28093_28093_1_EZH1-IGFBP5_EZH1_chr17_40879653_ENST00000435174_IGFBP5_chr2_217543802_ENST00000233813_length(amino acids)=183AA_BP=23 MEEASCPTCSVNEACEWTPFSQKERDSREHEEPTTSEMAEETYSPKIFRPKHTRISELKAEAVKKDRRKKLTQSKFVGGAENTAHPRIIS APEMRQESEQGPCRRHMEASLQELKASPRMVPRAVYLPNCDRKGFYKRKQCKPSRGRKRGICWCVDKYGMKLPGMEYVDGDFQCHTFDSS -------------------------------------------------------------- >28093_28093_2_EZH1-IGFBP5_EZH1_chr17_40879653_ENST00000590078_IGFBP5_chr2_217543802_ENST00000233813_length(transcript)=5375nt_BP=247nt AGCGGGACCCGCGGCTCGGGATGGAGGCTGGACACCTGTTCTGCTGTTGTGTCCTGCCATTCTCCTGAAGAACAGAGGCACACTGTAAAA CCCAACACTTCCCCTTGCATTCTATAAGGCTTTGTATGTGGCAAATTTTGCAAAGGTTCAAGAAAAAACCCAGATCCTCAATGAAGAATG GAAGAAGCTTCGTGTCCAACCTGTTCAGTCAATGAAGCCTGTGAGTGGACACCCTTTTCTCAAAAAGAGAGAGACTCCCGTGAGCACGAG GAGCCCACCACCTCTGAGATGGCCGAGGAGACCTACTCCCCCAAGATCTTCCGGCCCAAACACACCCGCATCTCCGAGCTGAAGGCTGAA GCAGTGAAGAAGGACCGCAGAAAGAAGCTGACCCAGTCCAAGTTTGTCGGGGGAGCCGAGAACACTGCCCACCCCCGGATCATCTCTGCA CCTGAGATGAGACAGGAGTCTGAGCAGGGCCCCTGCCGCAGACACATGGAGGCTTCCCTGCAGGAGCTCAAAGCCAGCCCACGCATGGTG CCCCGTGCTGTGTACCTGCCCAATTGTGACCGCAAAGGATTCTACAAGAGAAAGCAGTGCAAACCTTCCCGTGGCCGCAAACGTGGCATC TGCTGGTGCGTGGACAAGTACGGGATGAAGCTGCCAGGCATGGAGTACGTTGACGGGGACTTTCAGTGCCACACCTTCGACAGCAGCAAC GTTGAGTGATGCGTCCCCCCCCAACCTTTCCCTCACCCCCTCCCACCCCCAGCCCCGACTCCAGCCAGCGCCTCCCTCCACCCCAGGACG CCACTCATTTCATCTCATTTAAGGGAAAAATATATATCTATCTATTTGAGGAAACTGAGGACCTCGGAATCTCTAGCAAGGGCTCAACTT CGAAAATGGCAACAACAGAGATGCAAAAAGCTAAAAAGACACCCCCCCCCTTTAAATGGTTTTCTTTTTGAGGCAAGTTGGATGAACAGA GAAGGGAAGAGAGGAAGAACGAGAGGAAGAGAAGGGAAGGAAGTGTTTGTGTAGAAGAGAGAGAAAGACGAATAGAGTTAGGAAAAGGAA GACAAGCAGGTGGGCAGGAAGGACATGCACCGAGACCAGGCAGGGGCCCAACTTTCACGTCCAGCCCTGGCCTGGGGTCGGGAGAGGTGG GCGCTAGAAGATGCAGCCCAGGATGTGGCAATCAATGACACTATTGGGGTTTCCCAGGATGGATTGGTCAGGGGGAGAAAGGAAAAGGCA AAACACTCCAGGACCTCTCCCGGATCTGTCTCCTCCTCTAGCCAGCAGTATGGACAGCTGGACCCCTGAACTTCCTCTCCTCTTACCTGG GCAGAGTGTTGTCTCTCCCCAAATTTATAAAAACTAAAATGCATTCCATTCCTCTGAAAGCAAAACAAATTCATAATTGAGTGATATTAA ATAGAGAGGTTTTCGGAAGCAGATCTGTGAATATGAAATACATGTGCATATTTCATTCCCCAGGCAGACATTTTTTAGAAATCAATACAT GCCCCAATATTGGAAAGACTTGTTCTTCCACGGTGACTACAGTACATGCTGAAGCGTGCCGTTTCAGCCCTCATTTAATTCAATTTGTAA GTAGCGCAGCAGCCTCTGTGGGGGAGGATAGGCTGAAAAAAAAAAGTGGGCTCGTATTTATCTACAGGACTCCATATAGTCATATATAGG CATATAAATCTATTCTTTTTCTTTGTTTTTTTCTTTCTTCCTTTCTTTCAAAGGTTTGCATTAACTTTTCAAAGTAGTTCCTATAGGGGC ATTGAGGAGCTTCCTCATTCTGGGAAAACTGAGAAAACCCATATTCTCCTAATACAACCCGTAATAGCATTTTTGCCTGCCTCGAGGCAG AGTTTCCCGTGAGCAATAAACTCAGCTTTTTTGTGGGGCACAGTACTGGATTTGACAGTGATTCCCCACGTGTGTTCATCTGCACCCACC GAGCCAGGCAGAGGCCAGCCCTCCGTGGTGCACACAGCACGCGCCTCAGTCCATCCCATTTTAGTCTTTAAACCCTCAGGAAGTCACAGT CTCCGGACACCACACCACATGAGCCCAACAGGTCCACGATGGATCCACCAGTCCCACCCCAGCCTTTTCCTTTCATCTGAACAGAATGTG CATTTTTGGAAGCCTCCCTCACTCTCCATGCTGGCAGAGCAGGAGGGAGACTGAAGTAAGAGATGGCAGAGGGAGATGGTGGCAAAAAGG TTTAGATGCAGGAGAACAGTAAGATGGATGGTTCCGGCCAGAGTCGATGTGGGGAGGAACAGAGGGCTGAAGGGAGAGGGGGCTGACTGT TCCATTCTAGCTTTGGCACAAAGCAGCAGAAAGGGGGAAAAGCCAATAGAAATTTCCTTAGCTTCCCCACCATATGTATTTTCTAGGATT TGAGAGGAAAGAGAGGAAAATGGGGGAATGGGTTGCAAAATAGAAATGAGCTTAATCCAGGCCGCAGAGCCAGGGAAGGTGAGTAACTTT AGGAGGGTGCTAGACTTTAGAAGCCAGATAGGAAGAATCAGTCTAAACTGGCCATGCTTTGGAAGGGACAAGACTATGTGCTCCGCTGCC CACCTTCAGCCTGCAATGAGGGACTGAGGCCCACGAGTCTTTCCAGCTCTTCCTCCATTCTGGCCAGTCCCTGCATCCTCCCTGGGGTGG AGGATGGAAGGAAAGCTGGGACAAGCAGGGAACGCATGATTCAGGGATGCTGTCACTCGGCAGCCAGATTCCGAAACTCCCATTCTCCAA TGACTTCCTCAACCAATGGGTGGCCTTGTGACTGTTCTTTAAGGCTGAAGATATCCAGGAAAGGGGGCTTGGACACTGGCCAAGGAGACC CCTTCGTGCTGTGGACACAGCTCTCTTCACTCTTTGCTCATGGCATGACACAGCGGAGACCGCCTCCAACAACGAATTTGGGGCTACGAA GAGGAATAGCGAAAAAGCAAATCTGTTTCAACTGATGGGAACCCTATAGCTATAGAACTTGGGGGCTATCTCCTATGCCCCTGGACAGGA CAGTTGGCTGGGGACAGGAGAAGTGCTCAATCTTCATGAGACAAAGGGGCCCGATAGGGCCAGCAGCCACAAGGCCTTGACCTGCCGAGT CAGCATGCCCCATCTCTCTGCACAGCTGTCCCCTAAACCCAACTCACGTTTCTGTATGTCTTAGGCCAGTATCCCAAACCTCTTCCACGT CACTGTTCTTTCCACCCATTCTCCCTTTGCATCTTGAGCAGTTATCCAACTAGGATCTGCCAAGTGGATACTGGGGTGCCACTCCCCTGA GAAAAGACTGAGCCAGGAACTACAAGCTCCCCCCACATTCCTCCCAGCCTGGACCTAATTCTTGAGAGGGGCTCTCTCTTCACGGACTGT GTCTGGACTTTGAGCAGGCTTCTGCCCCTTGCGTTGGCTCTTTGCTGCCAGCCATCAGGTGGGGGATTAGAGCCTGGTGTAAGTGCGCCA GACTCTTCCGGTTTCCAAAGTTCGTGCCTGCGAACCCAAACCTGTGAGTCTCTTCTGCATGCAGGAGTTTCTCCTGGGCAGCTGGTCACT CCCCAGAGAAGCTGGGCCTTCATGGACACATGGAACTAAGCCTCCCAAATGGGAGTTCTGGCTGAGCCCAGGGTGGGGAGATCCTGGGAA GGGAGGCACTGGAGGAAGACGGCACCTCTTCCCCCATGGCAGGGTGTGAGGGAGGCAGGTTTGGAATGGTGCGAGTATGGCAATCTAAGC AGGGGTCTGGTCTCTTTGACTCCAGGCTGGCCTTTGGCCGACTGTCTGCTCACCCAGAGACCTTGGACTCCGGACTATCCATGGCTCCGA ATCTAAGTGCTGCCCACTCCCATGCTCACACCCACAGAAGGTCTTCCCATCCCCTTTAGATTCGTGCCTCACTCCACCAGTGAGGAAGAT GCCTCTGTCTTTCCCACGACTGCCAGGAGATAGGGAAGCCCAGCCAGGACTGACCCTCCTTCCTCCAGCCTGCCCTGACCCACCTGGCAA AGCAGGGCACATGGGGAGGAAGAGACTGGAACCTTTCTTTGACAGCCAGGCCTAGACAGACAGGCCTGGGGACACTGGCCCCATGAGGGG AGGAAGGCAGGCGCACGAGGTCCAGGGAGGCCCTTTTCTGATCATGCCCCTTCTCTCCCACCCCATCTCCCCACCACCACCTCTGTGGCC TCCATGGTACCCCCACAGGGCTGGCCTCCCCTAGAGGGTGGGCCTCAACCACCTGCTCCCGCCACGCACCGGTTAGTGAGACAGGGCTGC CACGGCAACCGCCAAGCCCCCCTCAAGGTGGGACAGTACCCCGGACCCATCCACTCACTCCTGAGAGGGCTCCGGCCCAGAATGGGAACC TCAGAGAAGAGCTCTAAGGAGAAGAAACCCCATAGCGTCAGAGAGGATATGTCTGGCTTCCAAGAGAAAGGAGGCTCCGTTTTGCAAAGT GGAGGAGGGACGAGGGACAGGGGTTTCACCAGCCAGCAACCTGGGCCTTGTACTGTCTGTGTTTTTAAAACCACTAAAGTGCAAGAATTA CATTGCACTGTTTCTCCACTTTTTATTTTCTCTTAGGCTTTTGTTTCTATTTCAAACATACTTTCTTGGTTTTCTAATGGAGTATATAGT TTAGTCATTTCACAGACTCTGGCCTCCTCTCCTGAAATCCTTTTGGATGGGGAAAGGGAAGGTGGGGAGGGTCCGAGGGGAAGGGGACCC CAGCTTCCCTGTGCCCGCTCACCCCACTCCACCAGTCCCCGGTCGCCAGCCGGAGTCTCCTCTCTACCGCCACTGTCACACCGTAGCCCA CATGGATAGCACAGTTGTCAGACAAGATTCCTTCAGATTCCGAGTTGCCTACCGGTTGTTTTCGTTGTTGTTGTTGTTGTTTTTCTTTTT CTTTTTTTTTTTGAAGACAGCAATAACCACAGTACATATTACTGTAGTTCTCTATAGTTTTACATACATTCATACCATAACTCTGTTCTC TCCTCTTTTTTGTTTTCAACTTTAAAAACAAAAATAAACGATGATAATCTTTACTGGTGAAAAGGATGGAAAAATAAATCAACAAATGCA ACCAGTTTGTGAGAAAAAAAAAAAAAAGCCGAAAAAAAAAAAAAAAACACCTGAATGCGGAAGAGCTCGGCTCCCGTTTAGCATTTTGTA CTTAAGGAAATAAAAAACCAACAAAGGATCTCACATTTTCTTAAAAAGTGAAGATTGCTGTATACTATTTATTCAACTTATAATTTATGT >28093_28093_2_EZH1-IGFBP5_EZH1_chr17_40879653_ENST00000590078_IGFBP5_chr2_217543802_ENST00000233813_length(amino acids)=183AA_BP=23 MEEASCPTCSVNEACEWTPFSQKERDSREHEEPTTSEMAEETYSPKIFRPKHTRISELKAEAVKKDRRKKLTQSKFVGGAENTAHPRIIS APEMRQESEQGPCRRHMEASLQELKASPRMVPRAVYLPNCDRKGFYKRKQCKPSRGRKRGICWCVDKYGMKLPGMEYVDGDFQCHTFDSS -------------------------------------------------------------- >28093_28093_3_EZH1-IGFBP5_EZH1_chr17_40879653_ENST00000592743_IGFBP5_chr2_217543802_ENST00000233813_length(transcript)=5424nt_BP=296nt ATGCGTCCTAGCAGCGGGACCCGCGGCTCGGGATGGAGGATTACAGCAAGATGGAAATACCAAATCCCCCTACCTCCAAATGTATCACTT ACTGGAAAAGAAAAGTGAAATCTGAATACATGCGACTTCGACAACTTAAACGGCTTCAGGCAAATATGGGTGCAAAGGCTTTGTATGTGG CAAATTTTGCAAAGGTTCAAGAAAAAACCCAGATCCTCAATGAAGAATGGAAGAAGCTTCGTGTCCAACCTGTTCAGTCAATGAAGCCTG TGAGTGGACACCCTTTTCTCAAAAAGAGAGAGACTCCCGTGAGCACGAGGAGCCCACCACCTCTGAGATGGCCGAGGAGACCTACTCCCC CAAGATCTTCCGGCCCAAACACACCCGCATCTCCGAGCTGAAGGCTGAAGCAGTGAAGAAGGACCGCAGAAAGAAGCTGACCCAGTCCAA GTTTGTCGGGGGAGCCGAGAACACTGCCCACCCCCGGATCATCTCTGCACCTGAGATGAGACAGGAGTCTGAGCAGGGCCCCTGCCGCAG ACACATGGAGGCTTCCCTGCAGGAGCTCAAAGCCAGCCCACGCATGGTGCCCCGTGCTGTGTACCTGCCCAATTGTGACCGCAAAGGATT CTACAAGAGAAAGCAGTGCAAACCTTCCCGTGGCCGCAAACGTGGCATCTGCTGGTGCGTGGACAAGTACGGGATGAAGCTGCCAGGCAT GGAGTACGTTGACGGGGACTTTCAGTGCCACACCTTCGACAGCAGCAACGTTGAGTGATGCGTCCCCCCCCAACCTTTCCCTCACCCCCT CCCACCCCCAGCCCCGACTCCAGCCAGCGCCTCCCTCCACCCCAGGACGCCACTCATTTCATCTCATTTAAGGGAAAAATATATATCTAT CTATTTGAGGAAACTGAGGACCTCGGAATCTCTAGCAAGGGCTCAACTTCGAAAATGGCAACAACAGAGATGCAAAAAGCTAAAAAGACA CCCCCCCCCTTTAAATGGTTTTCTTTTTGAGGCAAGTTGGATGAACAGAGAAGGGAAGAGAGGAAGAACGAGAGGAAGAGAAGGGAAGGA AGTGTTTGTGTAGAAGAGAGAGAAAGACGAATAGAGTTAGGAAAAGGAAGACAAGCAGGTGGGCAGGAAGGACATGCACCGAGACCAGGC AGGGGCCCAACTTTCACGTCCAGCCCTGGCCTGGGGTCGGGAGAGGTGGGCGCTAGAAGATGCAGCCCAGGATGTGGCAATCAATGACAC TATTGGGGTTTCCCAGGATGGATTGGTCAGGGGGAGAAAGGAAAAGGCAAAACACTCCAGGACCTCTCCCGGATCTGTCTCCTCCTCTAG CCAGCAGTATGGACAGCTGGACCCCTGAACTTCCTCTCCTCTTACCTGGGCAGAGTGTTGTCTCTCCCCAAATTTATAAAAACTAAAATG CATTCCATTCCTCTGAAAGCAAAACAAATTCATAATTGAGTGATATTAAATAGAGAGGTTTTCGGAAGCAGATCTGTGAATATGAAATAC ATGTGCATATTTCATTCCCCAGGCAGACATTTTTTAGAAATCAATACATGCCCCAATATTGGAAAGACTTGTTCTTCCACGGTGACTACA GTACATGCTGAAGCGTGCCGTTTCAGCCCTCATTTAATTCAATTTGTAAGTAGCGCAGCAGCCTCTGTGGGGGAGGATAGGCTGAAAAAA AAAAGTGGGCTCGTATTTATCTACAGGACTCCATATAGTCATATATAGGCATATAAATCTATTCTTTTTCTTTGTTTTTTTCTTTCTTCC TTTCTTTCAAAGGTTTGCATTAACTTTTCAAAGTAGTTCCTATAGGGGCATTGAGGAGCTTCCTCATTCTGGGAAAACTGAGAAAACCCA TATTCTCCTAATACAACCCGTAATAGCATTTTTGCCTGCCTCGAGGCAGAGTTTCCCGTGAGCAATAAACTCAGCTTTTTTGTGGGGCAC AGTACTGGATTTGACAGTGATTCCCCACGTGTGTTCATCTGCACCCACCGAGCCAGGCAGAGGCCAGCCCTCCGTGGTGCACACAGCACG CGCCTCAGTCCATCCCATTTTAGTCTTTAAACCCTCAGGAAGTCACAGTCTCCGGACACCACACCACATGAGCCCAACAGGTCCACGATG GATCCACCAGTCCCACCCCAGCCTTTTCCTTTCATCTGAACAGAATGTGCATTTTTGGAAGCCTCCCTCACTCTCCATGCTGGCAGAGCA GGAGGGAGACTGAAGTAAGAGATGGCAGAGGGAGATGGTGGCAAAAAGGTTTAGATGCAGGAGAACAGTAAGATGGATGGTTCCGGCCAG AGTCGATGTGGGGAGGAACAGAGGGCTGAAGGGAGAGGGGGCTGACTGTTCCATTCTAGCTTTGGCACAAAGCAGCAGAAAGGGGGAAAA GCCAATAGAAATTTCCTTAGCTTCCCCACCATATGTATTTTCTAGGATTTGAGAGGAAAGAGAGGAAAATGGGGGAATGGGTTGCAAAAT AGAAATGAGCTTAATCCAGGCCGCAGAGCCAGGGAAGGTGAGTAACTTTAGGAGGGTGCTAGACTTTAGAAGCCAGATAGGAAGAATCAG TCTAAACTGGCCATGCTTTGGAAGGGACAAGACTATGTGCTCCGCTGCCCACCTTCAGCCTGCAATGAGGGACTGAGGCCCACGAGTCTT TCCAGCTCTTCCTCCATTCTGGCCAGTCCCTGCATCCTCCCTGGGGTGGAGGATGGAAGGAAAGCTGGGACAAGCAGGGAACGCATGATT CAGGGATGCTGTCACTCGGCAGCCAGATTCCGAAACTCCCATTCTCCAATGACTTCCTCAACCAATGGGTGGCCTTGTGACTGTTCTTTA AGGCTGAAGATATCCAGGAAAGGGGGCTTGGACACTGGCCAAGGAGACCCCTTCGTGCTGTGGACACAGCTCTCTTCACTCTTTGCTCAT GGCATGACACAGCGGAGACCGCCTCCAACAACGAATTTGGGGCTACGAAGAGGAATAGCGAAAAAGCAAATCTGTTTCAACTGATGGGAA CCCTATAGCTATAGAACTTGGGGGCTATCTCCTATGCCCCTGGACAGGACAGTTGGCTGGGGACAGGAGAAGTGCTCAATCTTCATGAGA CAAAGGGGCCCGATAGGGCCAGCAGCCACAAGGCCTTGACCTGCCGAGTCAGCATGCCCCATCTCTCTGCACAGCTGTCCCCTAAACCCA ACTCACGTTTCTGTATGTCTTAGGCCAGTATCCCAAACCTCTTCCACGTCACTGTTCTTTCCACCCATTCTCCCTTTGCATCTTGAGCAG TTATCCAACTAGGATCTGCCAAGTGGATACTGGGGTGCCACTCCCCTGAGAAAAGACTGAGCCAGGAACTACAAGCTCCCCCCACATTCC TCCCAGCCTGGACCTAATTCTTGAGAGGGGCTCTCTCTTCACGGACTGTGTCTGGACTTTGAGCAGGCTTCTGCCCCTTGCGTTGGCTCT TTGCTGCCAGCCATCAGGTGGGGGATTAGAGCCTGGTGTAAGTGCGCCAGACTCTTCCGGTTTCCAAAGTTCGTGCCTGCGAACCCAAAC CTGTGAGTCTCTTCTGCATGCAGGAGTTTCTCCTGGGCAGCTGGTCACTCCCCAGAGAAGCTGGGCCTTCATGGACACATGGAACTAAGC CTCCCAAATGGGAGTTCTGGCTGAGCCCAGGGTGGGGAGATCCTGGGAAGGGAGGCACTGGAGGAAGACGGCACCTCTTCCCCCATGGCA GGGTGTGAGGGAGGCAGGTTTGGAATGGTGCGAGTATGGCAATCTAAGCAGGGGTCTGGTCTCTTTGACTCCAGGCTGGCCTTTGGCCGA CTGTCTGCTCACCCAGAGACCTTGGACTCCGGACTATCCATGGCTCCGAATCTAAGTGCTGCCCACTCCCATGCTCACACCCACAGAAGG TCTTCCCATCCCCTTTAGATTCGTGCCTCACTCCACCAGTGAGGAAGATGCCTCTGTCTTTCCCACGACTGCCAGGAGATAGGGAAGCCC AGCCAGGACTGACCCTCCTTCCTCCAGCCTGCCCTGACCCACCTGGCAAAGCAGGGCACATGGGGAGGAAGAGACTGGAACCTTTCTTTG ACAGCCAGGCCTAGACAGACAGGCCTGGGGACACTGGCCCCATGAGGGGAGGAAGGCAGGCGCACGAGGTCCAGGGAGGCCCTTTTCTGA TCATGCCCCTTCTCTCCCACCCCATCTCCCCACCACCACCTCTGTGGCCTCCATGGTACCCCCACAGGGCTGGCCTCCCCTAGAGGGTGG GCCTCAACCACCTGCTCCCGCCACGCACCGGTTAGTGAGACAGGGCTGCCACGGCAACCGCCAAGCCCCCCTCAAGGTGGGACAGTACCC CGGACCCATCCACTCACTCCTGAGAGGGCTCCGGCCCAGAATGGGAACCTCAGAGAAGAGCTCTAAGGAGAAGAAACCCCATAGCGTCAG AGAGGATATGTCTGGCTTCCAAGAGAAAGGAGGCTCCGTTTTGCAAAGTGGAGGAGGGACGAGGGACAGGGGTTTCACCAGCCAGCAACC TGGGCCTTGTACTGTCTGTGTTTTTAAAACCACTAAAGTGCAAGAATTACATTGCACTGTTTCTCCACTTTTTATTTTCTCTTAGGCTTT TGTTTCTATTTCAAACATACTTTCTTGGTTTTCTAATGGAGTATATAGTTTAGTCATTTCACAGACTCTGGCCTCCTCTCCTGAAATCCT TTTGGATGGGGAAAGGGAAGGTGGGGAGGGTCCGAGGGGAAGGGGACCCCAGCTTCCCTGTGCCCGCTCACCCCACTCCACCAGTCCCCG GTCGCCAGCCGGAGTCTCCTCTCTACCGCCACTGTCACACCGTAGCCCACATGGATAGCACAGTTGTCAGACAAGATTCCTTCAGATTCC GAGTTGCCTACCGGTTGTTTTCGTTGTTGTTGTTGTTGTTTTTCTTTTTCTTTTTTTTTTTGAAGACAGCAATAACCACAGTACATATTA CTGTAGTTCTCTATAGTTTTACATACATTCATACCATAACTCTGTTCTCTCCTCTTTTTTGTTTTCAACTTTAAAAACAAAAATAAACGA TGATAATCTTTACTGGTGAAAAGGATGGAAAAATAAATCAACAAATGCAACCAGTTTGTGAGAAAAAAAAAAAAAAGCCGAAAAAAAAAA AAAAAACACCTGAATGCGGAAGAGCTCGGCTCCCGTTTAGCATTTTGTACTTAAGGAAATAAAAAACCAACAAAGGATCTCACATTTTCT TAAAAAGTGAAGATTGCTGTATACTATTTATTCAACTTATAATTTATGTTACTCCTTGATCTTTGTCTTTTGTCATGACAAAGCATTTAT >28093_28093_3_EZH1-IGFBP5_EZH1_chr17_40879653_ENST00000592743_IGFBP5_chr2_217543802_ENST00000233813_length(amino acids)=183AA_BP=23 MEEASCPTCSVNEACEWTPFSQKERDSREHEEPTTSEMAEETYSPKIFRPKHTRISELKAEAVKKDRRKKLTQSKFVGGAENTAHPRIIS APEMRQESEQGPCRRHMEASLQELKASPRMVPRAVYLPNCDRKGFYKRKQCKPSRGRKRGICWCVDKYGMKLPGMEYVDGDFQCHTFDSS -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for EZH1-IGFBP5 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for EZH1-IGFBP5 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for EZH1-IGFBP5 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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