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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:EZH1-PDSS2 (FusionGDB2 ID:28095)

Fusion Gene Summary for EZH1-PDSS2

check button Fusion gene summary
Fusion gene informationFusion gene name: EZH1-PDSS2
Fusion gene ID: 28095
HgeneTgene
Gene symbol

EZH1

PDSS2

Gene ID

2145

57107

Gene nameenhancer of zeste 1 polycomb repressive complex 2 subunitdecaprenyl diphosphate synthase subunit 2
SynonymsKMT6BC6orf210|COQ10D3|COQ1B|DLP1|bA59I9.3|hDLP1
Cytomap

17q21.2

6q21

Type of geneprotein-codingprotein-coding
Descriptionhistone-lysine N-methyltransferase EZH1ENX-2enhancer of zeste homolog 1decaprenyl-diphosphate synthase subunit 2all-trans-decaprenyl-diphosphate synthase subunit 2decaprenyl pyrophosphate synthase subunit 2decaprenyl pyrophosphate synthetase subunit 2prenyl (decaprenyl) diphosphate synthase, subunit 2subunit 2 of decapr
Modification date2020031520200313
UniProtAcc

Q92800

.
Ensembl transtripts involved in fusion geneENST00000435174, ENST00000590078, 
ENST00000592743, ENST00000428826, 
ENST00000585893, ENST00000415827, 
ENST00000590783, 		ENST00000369031, 
ENST00000369037, ENST00000453874, 
Fusion gene scores* DoF score8 X 12 X 6=5769 X 7 X 6=378
# samples 1210
** MAII scorelog2(12/576*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/378*10)=-1.91838623444635
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EZH1 [Title/Abstract] AND PDSS2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointEZH1(40879653)-PDSS2(107595431), # samples:3
Anticipated loss of major functional domain due to fusion event.EZH1-PDSS2 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
EZH1-PDSS2 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
EZH1-PDSS2 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
EZH1-PDSS2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
EZH1-PDSS2 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePDSS2

GO:0006744

ubiquinone biosynthetic process

16262699

TgenePDSS2

GO:0008299

isoprenoid biosynthetic process

16262699


check buttonFusion gene breakpoints across EZH1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PDSS2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PCPGTCGA-WB-A81F-01AEZH1chr17

40879653

-PDSS2chr6

107595431

-


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Fusion Gene ORF analysis for EZH1-PDSS2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000435174ENST00000369031EZH1chr17

40879653

-PDSS2chr6

107595431

-
Frame-shiftENST00000435174ENST00000369037EZH1chr17

40879653

-PDSS2chr6

107595431

-
Frame-shiftENST00000435174ENST00000453874EZH1chr17

40879653

-PDSS2chr6

107595431

-
Frame-shiftENST00000590078ENST00000369031EZH1chr17

40879653

-PDSS2chr6

107595431

-
Frame-shiftENST00000590078ENST00000369037EZH1chr17

40879653

-PDSS2chr6

107595431

-
Frame-shiftENST00000590078ENST00000453874EZH1chr17

40879653

-PDSS2chr6

107595431

-
Frame-shiftENST00000592743ENST00000369031EZH1chr17

40879653

-PDSS2chr6

107595431

-
Frame-shiftENST00000592743ENST00000369037EZH1chr17

40879653

-PDSS2chr6

107595431

-
Frame-shiftENST00000592743ENST00000453874EZH1chr17

40879653

-PDSS2chr6

107595431

-
In-frameENST00000428826ENST00000369031EZH1chr17

40879653

-PDSS2chr6

107595431

-
In-frameENST00000428826ENST00000369037EZH1chr17

40879653

-PDSS2chr6

107595431

-
In-frameENST00000428826ENST00000453874EZH1chr17

40879653

-PDSS2chr6

107595431

-
In-frameENST00000585893ENST00000369031EZH1chr17

40879653

-PDSS2chr6

107595431

-
In-frameENST00000585893ENST00000369037EZH1chr17

40879653

-PDSS2chr6

107595431

-
In-frameENST00000585893ENST00000453874EZH1chr17

40879653

-PDSS2chr6

107595431

-
intron-3CDSENST00000415827ENST00000369031EZH1chr17

40879653

-PDSS2chr6

107595431

-
intron-3CDSENST00000415827ENST00000369037EZH1chr17

40879653

-PDSS2chr6

107595431

-
intron-3CDSENST00000415827ENST00000453874EZH1chr17

40879653

-PDSS2chr6

107595431

-
intron-3CDSENST00000590783ENST00000369031EZH1chr17

40879653

-PDSS2chr6

107595431

-
intron-3CDSENST00000590783ENST00000369037EZH1chr17

40879653

-PDSS2chr6

107595431

-
intron-3CDSENST00000590783ENST00000453874EZH1chr17

40879653

-PDSS2chr6

107595431

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000428826EZH1chr1740879653-ENST00000369037PDSS2chr6107595431-31993683781136252
ENST00000428826EZH1chr1740879653-ENST00000453874PDSS2chr6107595431-1004368378830150
ENST00000428826EZH1chr1740879653-ENST00000369031PDSS2chr6107595431-894368122445107
ENST00000585893EZH1chr1740879653-ENST00000369037PDSS2chr6107595431-32003693791137252
ENST00000585893EZH1chr1740879653-ENST00000453874PDSS2chr6107595431-1005369379831150
ENST00000585893EZH1chr1740879653-ENST00000369031PDSS2chr6107595431-895369123446107

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000428826ENST00000369037EZH1chr1740879653-PDSS2chr6107595431-0.0007757720.9992242
ENST00000428826ENST00000453874EZH1chr1740879653-PDSS2chr6107595431-0.0074707030.9925292
ENST00000428826ENST00000369031EZH1chr1740879653-PDSS2chr6107595431-0.180057390.8199426
ENST00000585893ENST00000369037EZH1chr1740879653-PDSS2chr6107595431-0.0007758020.9992242
ENST00000585893ENST00000453874EZH1chr1740879653-PDSS2chr6107595431-0.0077530350.992247
ENST00000585893ENST00000369031EZH1chr1740879653-PDSS2chr6107595431-0.185263250.8147368

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Fusion Genomic Features for EZH1-PDSS2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for EZH1-PDSS2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:40879653/chr6:107595431)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EZH1

Q92800

.
FUNCTION: Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH2-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. {ECO:0000269|PubMed:19026781}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEZH1chr17:40879653chr6:107595431ENST00000428826-421524_60682748.0Compositional biasNote=Cys-rich
HgeneEZH1chr17:40879653chr6:107595431ENST00000435174-419524_60623609.0Compositional biasNote=Cys-rich
HgeneEZH1chr17:40879653chr6:107595431ENST00000585893-420524_60682708.0Compositional biasNote=Cys-rich
HgeneEZH1chr17:40879653chr6:107595431ENST00000590078-320524_60612678.0Compositional biasNote=Cys-rich
HgeneEZH1chr17:40879653chr6:107595431ENST00000592743-320524_60682748.0Compositional biasNote=Cys-rich
HgeneEZH1chr17:40879653chr6:107595431ENST00000428826-421504_60682748.0DomainCXC
HgeneEZH1chr17:40879653chr6:107595431ENST00000428826-421613_72882748.0DomainSET
HgeneEZH1chr17:40879653chr6:107595431ENST00000435174-419504_60623609.0DomainCXC
HgeneEZH1chr17:40879653chr6:107595431ENST00000435174-419613_72823609.0DomainSET
HgeneEZH1chr17:40879653chr6:107595431ENST00000585893-420504_60682708.0DomainCXC
HgeneEZH1chr17:40879653chr6:107595431ENST00000585893-420613_72882708.0DomainSET
HgeneEZH1chr17:40879653chr6:107595431ENST00000590078-320504_60612678.0DomainCXC
HgeneEZH1chr17:40879653chr6:107595431ENST00000590078-320613_72812678.0DomainSET
HgeneEZH1chr17:40879653chr6:107595431ENST00000592743-320504_60682748.0DomainCXC
HgeneEZH1chr17:40879653chr6:107595431ENST00000592743-320613_72882748.0DomainSET
HgeneEZH1chr17:40879653chr6:107595431ENST00000428826-421491_49682748.0MotifNuclear localization signal
HgeneEZH1chr17:40879653chr6:107595431ENST00000435174-419491_49623609.0MotifNuclear localization signal
HgeneEZH1chr17:40879653chr6:107595431ENST00000585893-420491_49682708.0MotifNuclear localization signal
HgeneEZH1chr17:40879653chr6:107595431ENST00000590078-320491_49612678.0MotifNuclear localization signal
HgeneEZH1chr17:40879653chr6:107595431ENST00000592743-320491_49682748.0MotifNuclear localization signal


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Fusion Gene Sequence for EZH1-PDSS2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>28095_28095_1_EZH1-PDSS2_EZH1_chr17_40879653_ENST00000428826_PDSS2_chr6_107595431_ENST00000369031_length(transcript)=894nt_BP=368nt
CCCGCGGCTCGGGATGGAGGCTGGACACCTGTTCTGCTGTTGTGTCCTGCCATTCTCCTGAAGAACAGAGGCACACTGTAAAACCCAACA
CTTCCCCTTGCATTCTATAAGATTACAGCAAGATGGAAATACCAAATCCCCCTACCTCCAAATGTATCACTTACTGGAAAAGAAAAGTGA
AATCTGAATACATGCGACTTCGACAACTTAAACGGCTTCAGGCAAATATGGGTGCAAAGGCTTTGTATGTGGCAAATTTTGCAAAGGTTC
AAGAAAAAACCCAGATCCTCAATGAAGAATGGAAGAAGCTTCGTGTCCAACCTGTTCAGTCAATGAAGCCTGTGAGTGGACACCCTTTTC
TCAAAAAGTCAAAGAAGTTTGGCAGAGATCACGGAGCTAATTCATATTGCTCTCCTTGTACATCGTGGGATAGTAAATTTAAATGAGTTG
CAATCATCTGATGGTCCACTGAAAGACATGCAATTTGGAAATAAAATTGCTATCCTGAGTGGAGACTTTCTTCTAGCAAATGCCTGCAAT
GGACTAGCTCTGCTACAGAACACCAAGTCATTTTCATTTAATGGACCTATTGCTATATATCAGATGGGAGACTGTGAGTCAGCCTGGATC
TTGTCTAAACACCCAAGAGCATTGTCATGATGTCACTCCTGGAGGTTGTTCTATTAAGCATTAGTGATTTATACTTCCGGATAACCAGTG
GCACAGATGTACTCTTTACATAGCTGATGTATTTCCTTATGTTAACTTTGTTTTCCTAAAGGCGTAAATATGTTGTTTAAAATGAAGTAT

>28095_28095_1_EZH1-PDSS2_EZH1_chr17_40879653_ENST00000428826_PDSS2_chr6_107595431_ENST00000369031_length(amino acids)=107AA_BP=82
MEIPNPPTSKCITYWKRKVKSEYMRLRQLKRLQANMGAKALYVANFAKVQEKTQILNEEWKKLRVQPVQSMKPVSGHPFLKKSKKFGRDH

--------------------------------------------------------------
>28095_28095_2_EZH1-PDSS2_EZH1_chr17_40879653_ENST00000428826_PDSS2_chr6_107595431_ENST00000369037_length(transcript)=3199nt_BP=368nt
CCCGCGGCTCGGGATGGAGGCTGGACACCTGTTCTGCTGTTGTGTCCTGCCATTCTCCTGAAGAACAGAGGCACACTGTAAAACCCAACA
CTTCCCCTTGCATTCTATAAGATTACAGCAAGATGGAAATACCAAATCCCCCTACCTCCAAATGTATCACTTACTGGAAAAGAAAAGTGA
AATCTGAATACATGCGACTTCGACAACTTAAACGGCTTCAGGCAAATATGGGTGCAAAGGCTTTGTATGTGGCAAATTTTGCAAAGGTTC
AAGAAAAAACCCAGATCCTCAATGAAGAATGGAAGAAGCTTCGTGTCCAACCTGTTCAGTCAATGAAGCCTGTGAGTGGACACCCTTTTC
TCAAAAAGTCAAAGAAGTTTGGCAGAGATCACGGAGCTAATTCATATTGCTCTCCTTGTACATCGTGGGATAGTAAATTTAAATGAGTTG
CAATCATCTGATGGTCCACTGAAAGACATGCAATTTGGAAATAAAATTGCTATCCTGAGTGGAGACTTTCTTCTAGCAAATGCCTGCAAT
GGACTAGCTCTGCTACAGAACACCAAGGTTGTGGAACTTTTAGCAAGTGCTCTTATGGACTTGGTACAAGGAGTATATCATGAAAATTCT
ACTTCAAAGGAAAGTTATATCACAGATGATATTGGAATATCGACTTGGAAGGAGCAGACTTTTCTCTCCCATGGTGCCTTACTAGCAAAG
AGCTGCCAAGCTGCAATGGAATTAGCAAAGCATGATGCTGAGGTTCAGAATATGGCATTTCAGTATGGGAAGCACATGGCCATGAGTCAT
AAGATAAATTCTGATGTCCAGCCTTTTATTAAAGAAAAGACCAGTGACTCCATGACTTTTAATCTAAACTCAGCTCCTGTAGTCTTACAT
CAGGAATTTCTTGGAAGAGATTTGTGGATTAAACAGATCGGAGAGGCTCAAGAAAAAGGAAGATTGGACTATGCTAAGTTGCGAGAAAGA
ATCAAAGCTGGCAAAGGTGTGACTTCAGCTATTGACCTGTGTCGTTACCATGGAAACAAGGCACTGGAGGCCCTGGAGAGCTTTCCTCCC
TCGGAGGCCAGATCTGCTTTAGAAAACATTGTGTTTGCTGTGACCAGATTTTCATGACATCAAATTAAAAAGACACTATTGTTAGTTAGC
TGAAAATCCTAGGGAATGAGGTTGATTGGGAGCGCTTTCACGATGCGTTAATGACTTTTAAAACATATGCATTTTTCCTTCCTTTTATCA
CATTGCTAAATGAGTTCTGCTTTCTTTTTGGAACTGCTACAAACAAAATTAGAAGAAAAAAAGGTCAAGCAGTTTTCACTTGTCACGCCA
GAAGCACACTTGAGGCTGCAGTCGCAGAAATAATTAATGAGATTCGCTCCTGTGACCTCAGCAAATGGACAGGAAATAAGTCCTTATTGA
TTGGACCGAGCCAGGGATGGCGCCAGGGCGGTGGCCTGTGGTTTTTCCTGCTAGAGAGGACAAAGCAAGTTGGAAGCTGCAGGTGTCAAG
AGAAATGCTCTCAATACCAACCAGGGAGGATTGTCTAATCAAAAACTAGTGACCAATTTGTCATAATGGAGAGTAGTTCAATGGATTGAG
AAAAATATGTTTTATTTGTTGGCTTGTAATTATGTCTCTGGATTATTATTATTTTTTTTTTAGATGTAGTTTTGCTCTTGTTGCCCAGGC
TGGAGTGCAATGGTGCAGTTTTGACTCACTGCAACCTCCGCCTCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGAA
TTACAGGCACCTGCCACCACGCCTGGCTAATTTTGTATTTTTAGTAGAGATGGGGTTTCACTATGTTGGTCAGGCTAGTCTCGAACTCCT
GACCTCAGGTGATCCGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTAGAGGCTTGAGCCACTGCACCTGGCCTCATGTCTCTGGATTTAT
AATGCAGTATGAATATACTTTGTGCTTTATGGTTTTTATAATGTCTTTTTGGAGAAATTGCCGAAAAGTTGCCAAATACTTGAAGTAGGA
GATTAAAATGTTATCAAATGTTAAATTGGTTATATTAGGAATAGTCTGTTTTTCTTTCCTGAAGATCAGTTTTTTTATTCAAACACATTT
CAAAGAACCAAATTTTTTTTTTCTTTAAGGAAAAAGGAGCTTTTTTTCAAGTGAAATGTATTCATTTGTAATACTTTGGTTTAAGGCATA
CTTTAATTTTTACGAGTTTCAGAAACAGAATTTTTGTACTAGGGAATTCATTGGTGAGAGTGTTCTTTTAACCTCAGAATGTCAAATTTT
GGTCTTGAACCACAGACATCCAATTACAGAAAGAATATAAGCAATCTCACAGGCCTGCAATCGGACACTGTCTCTGTGTGGTTCATAGGA
GATGATTTTTGAGGTTTGCACTCATGCAATTTGAGAACACCGTTGACAAGAAGGCTGAGTTTACATAAATGATCTAGATTGAAACTCAGC
TACCTTTCTTCCTCATGTGGTGTAATTACAGCCCTATCTGGAGACAGCGAATACAGCAAACAGATTTTATTACCTAGTTCGCTCAAACAC
TACATGAAGTTATTTTAGTTAAAGCCCTCCCCCAAAAGTTATAAAACCATTTTATCAGGGCCCAACATGTGGCATGCAATGAAGAGAAAA
TGTAAAGCTACAGAGGTTAATGTATTGTATTATAAAATATTTTAAGTGTACTCAAAATATCATAATTGTACAGTTTATGCCACCATAATT
TGAGGCCTATAGATTTAGCTTAAGAGAACACTGTTCTGTTTGAAATGCTTTCTGTCACTGAAATTGGCTTAATTAGTAACCATGGATAAG
ATGCTTTAGATCAGACTAGGTTTTAATCATTAACTTCCACAAAGAAGTCATACTTTGCGTTAGGTGTGCTGGTTGGATGTGCAGGAACTT
CAGCAAGCAGTAGGTTTTACTAAGCAGATGGTCGGGCACTGCAGGGCACCAGGCAGGATCCTAGGGCGCCTCTTATTCTGCGTTAGCATC
TGGTTTGCTGTATGACCTTGCACAAGTCACTTCCTTCTGAGCCTCAATTTTCTCATCTGTACAATGAGATTCAAAAGTTGACCTGAAAGT

>28095_28095_2_EZH1-PDSS2_EZH1_chr17_40879653_ENST00000428826_PDSS2_chr6_107595431_ENST00000369037_length(amino acids)=252AA_BP=
MAEITELIHIALLVHRGIVNLNELQSSDGPLKDMQFGNKIAILSGDFLLANACNGLALLQNTKVVELLASALMDLVQGVYHENSTSKESY
ITDDIGISTWKEQTFLSHGALLAKSCQAAMELAKHDAEVQNMAFQYGKHMAMSHKINSDVQPFIKEKTSDSMTFNLNSAPVVLHQEFLGR

--------------------------------------------------------------
>28095_28095_3_EZH1-PDSS2_EZH1_chr17_40879653_ENST00000428826_PDSS2_chr6_107595431_ENST00000453874_length(transcript)=1004nt_BP=368nt
CCCGCGGCTCGGGATGGAGGCTGGACACCTGTTCTGCTGTTGTGTCCTGCCATTCTCCTGAAGAACAGAGGCACACTGTAAAACCCAACA
CTTCCCCTTGCATTCTATAAGATTACAGCAAGATGGAAATACCAAATCCCCCTACCTCCAAATGTATCACTTACTGGAAAAGAAAAGTGA
AATCTGAATACATGCGACTTCGACAACTTAAACGGCTTCAGGCAAATATGGGTGCAAAGGCTTTGTATGTGGCAAATTTTGCAAAGGTTC
AAGAAAAAACCCAGATCCTCAATGAAGAATGGAAGAAGCTTCGTGTCCAACCTGTTCAGTCAATGAAGCCTGTGAGTGGACACCCTTTTC
TCAAAAAGTCAAAGAAGTTTGGCAGAGATCACGGAGCTAATTCATATTGCTCTCCTTGTACATCGTGGGATAGTAAATTTAAATGAGTTG
CAATCATCTGATGGTCCACTGAAAGACATGCAATTTGGAAATAAAATTGCTATCCTGAGTGGAGACTTTCTTCTAGCAAATGCCTGCAAT
GGACTAGCTCTGCTACAGAACACCAAGGTTGTGGAACTTTTAGCAAGTGCTCTTATGGACTTGGTACAAGGAGTATATCATGAAAATTCT
ACTTCAAAGGCTCAAGAAAAAGGAAGATTGGACTATGCTAAGTTGCGAGAAAGAATCAAAGCTGGCAAAGGTGTGACTTCAGCTATTGAC
CTGTGTCGTTACCATGGAAACAAGGCACTGGAGGCCCTGGAGAGCTTTCCTCCCTCGGAGGCCAGATCTGCTTTAGAAAACATTGTGTTT
GCTGTGACCAGATTTTCATGACATCAAATTAAAAAGACACTATTGTTAGTTAGCTGAAAATCCTAGGGAATGAGGTTGATTGGGAGCGCT
TTCACGATGCGTTAATGACTTTTAAAACATATGCATTTTTCCTTCCTTTTATCACATTGCTAAATGAGTTCTGCTTTCTTTTTGGAACTG

>28095_28095_3_EZH1-PDSS2_EZH1_chr17_40879653_ENST00000428826_PDSS2_chr6_107595431_ENST00000453874_length(amino acids)=150AA_BP=
MAEITELIHIALLVHRGIVNLNELQSSDGPLKDMQFGNKIAILSGDFLLANACNGLALLQNTKVVELLASALMDLVQGVYHENSTSKAQE

--------------------------------------------------------------
>28095_28095_4_EZH1-PDSS2_EZH1_chr17_40879653_ENST00000585893_PDSS2_chr6_107595431_ENST00000369031_length(transcript)=895nt_BP=369nt
ACCCGCGGCTCGGGATGGAGGCTGGACACCTGTTCTGCTGTTGTGTCCTGCCATTCTCCTGAAGAACAGAGGCACACTGTAAAACCCAAC
ACTTCCCCTTGCATTCTATAAGATTACAGCAAGATGGAAATACCAAATCCCCCTACCTCCAAATGTATCACTTACTGGAAAAGAAAAGTG
AAATCTGAATACATGCGACTTCGACAACTTAAACGGCTTCAGGCAAATATGGGTGCAAAGGCTTTGTATGTGGCAAATTTTGCAAAGGTT
CAAGAAAAAACCCAGATCCTCAATGAAGAATGGAAGAAGCTTCGTGTCCAACCTGTTCAGTCAATGAAGCCTGTGAGTGGACACCCTTTT
CTCAAAAAGTCAAAGAAGTTTGGCAGAGATCACGGAGCTAATTCATATTGCTCTCCTTGTACATCGTGGGATAGTAAATTTAAATGAGTT
GCAATCATCTGATGGTCCACTGAAAGACATGCAATTTGGAAATAAAATTGCTATCCTGAGTGGAGACTTTCTTCTAGCAAATGCCTGCAA
TGGACTAGCTCTGCTACAGAACACCAAGTCATTTTCATTTAATGGACCTATTGCTATATATCAGATGGGAGACTGTGAGTCAGCCTGGAT
CTTGTCTAAACACCCAAGAGCATTGTCATGATGTCACTCCTGGAGGTTGTTCTATTAAGCATTAGTGATTTATACTTCCGGATAACCAGT
GGCACAGATGTACTCTTTACATAGCTGATGTATTTCCTTATGTTAACTTTGTTTTCCTAAAGGCGTAAATATGTTGTTTAAAATGAAGTA

>28095_28095_4_EZH1-PDSS2_EZH1_chr17_40879653_ENST00000585893_PDSS2_chr6_107595431_ENST00000369031_length(amino acids)=107AA_BP=82
MEIPNPPTSKCITYWKRKVKSEYMRLRQLKRLQANMGAKALYVANFAKVQEKTQILNEEWKKLRVQPVQSMKPVSGHPFLKKSKKFGRDH

--------------------------------------------------------------
>28095_28095_5_EZH1-PDSS2_EZH1_chr17_40879653_ENST00000585893_PDSS2_chr6_107595431_ENST00000369037_length(transcript)=3200nt_BP=369nt
ACCCGCGGCTCGGGATGGAGGCTGGACACCTGTTCTGCTGTTGTGTCCTGCCATTCTCCTGAAGAACAGAGGCACACTGTAAAACCCAAC
ACTTCCCCTTGCATTCTATAAGATTACAGCAAGATGGAAATACCAAATCCCCCTACCTCCAAATGTATCACTTACTGGAAAAGAAAAGTG
AAATCTGAATACATGCGACTTCGACAACTTAAACGGCTTCAGGCAAATATGGGTGCAAAGGCTTTGTATGTGGCAAATTTTGCAAAGGTT
CAAGAAAAAACCCAGATCCTCAATGAAGAATGGAAGAAGCTTCGTGTCCAACCTGTTCAGTCAATGAAGCCTGTGAGTGGACACCCTTTT
CTCAAAAAGTCAAAGAAGTTTGGCAGAGATCACGGAGCTAATTCATATTGCTCTCCTTGTACATCGTGGGATAGTAAATTTAAATGAGTT
GCAATCATCTGATGGTCCACTGAAAGACATGCAATTTGGAAATAAAATTGCTATCCTGAGTGGAGACTTTCTTCTAGCAAATGCCTGCAA
TGGACTAGCTCTGCTACAGAACACCAAGGTTGTGGAACTTTTAGCAAGTGCTCTTATGGACTTGGTACAAGGAGTATATCATGAAAATTC
TACTTCAAAGGAAAGTTATATCACAGATGATATTGGAATATCGACTTGGAAGGAGCAGACTTTTCTCTCCCATGGTGCCTTACTAGCAAA
GAGCTGCCAAGCTGCAATGGAATTAGCAAAGCATGATGCTGAGGTTCAGAATATGGCATTTCAGTATGGGAAGCACATGGCCATGAGTCA
TAAGATAAATTCTGATGTCCAGCCTTTTATTAAAGAAAAGACCAGTGACTCCATGACTTTTAATCTAAACTCAGCTCCTGTAGTCTTACA
TCAGGAATTTCTTGGAAGAGATTTGTGGATTAAACAGATCGGAGAGGCTCAAGAAAAAGGAAGATTGGACTATGCTAAGTTGCGAGAAAG
AATCAAAGCTGGCAAAGGTGTGACTTCAGCTATTGACCTGTGTCGTTACCATGGAAACAAGGCACTGGAGGCCCTGGAGAGCTTTCCTCC
CTCGGAGGCCAGATCTGCTTTAGAAAACATTGTGTTTGCTGTGACCAGATTTTCATGACATCAAATTAAAAAGACACTATTGTTAGTTAG
CTGAAAATCCTAGGGAATGAGGTTGATTGGGAGCGCTTTCACGATGCGTTAATGACTTTTAAAACATATGCATTTTTCCTTCCTTTTATC
ACATTGCTAAATGAGTTCTGCTTTCTTTTTGGAACTGCTACAAACAAAATTAGAAGAAAAAAAGGTCAAGCAGTTTTCACTTGTCACGCC
AGAAGCACACTTGAGGCTGCAGTCGCAGAAATAATTAATGAGATTCGCTCCTGTGACCTCAGCAAATGGACAGGAAATAAGTCCTTATTG
ATTGGACCGAGCCAGGGATGGCGCCAGGGCGGTGGCCTGTGGTTTTTCCTGCTAGAGAGGACAAAGCAAGTTGGAAGCTGCAGGTGTCAA
GAGAAATGCTCTCAATACCAACCAGGGAGGATTGTCTAATCAAAAACTAGTGACCAATTTGTCATAATGGAGAGTAGTTCAATGGATTGA
GAAAAATATGTTTTATTTGTTGGCTTGTAATTATGTCTCTGGATTATTATTATTTTTTTTTTAGATGTAGTTTTGCTCTTGTTGCCCAGG
CTGGAGTGCAATGGTGCAGTTTTGACTCACTGCAACCTCCGCCTCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGA
ATTACAGGCACCTGCCACCACGCCTGGCTAATTTTGTATTTTTAGTAGAGATGGGGTTTCACTATGTTGGTCAGGCTAGTCTCGAACTCC
TGACCTCAGGTGATCCGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTAGAGGCTTGAGCCACTGCACCTGGCCTCATGTCTCTGGATTTA
TAATGCAGTATGAATATACTTTGTGCTTTATGGTTTTTATAATGTCTTTTTGGAGAAATTGCCGAAAAGTTGCCAAATACTTGAAGTAGG
AGATTAAAATGTTATCAAATGTTAAATTGGTTATATTAGGAATAGTCTGTTTTTCTTTCCTGAAGATCAGTTTTTTTATTCAAACACATT
TCAAAGAACCAAATTTTTTTTTTCTTTAAGGAAAAAGGAGCTTTTTTTCAAGTGAAATGTATTCATTTGTAATACTTTGGTTTAAGGCAT
ACTTTAATTTTTACGAGTTTCAGAAACAGAATTTTTGTACTAGGGAATTCATTGGTGAGAGTGTTCTTTTAACCTCAGAATGTCAAATTT
TGGTCTTGAACCACAGACATCCAATTACAGAAAGAATATAAGCAATCTCACAGGCCTGCAATCGGACACTGTCTCTGTGTGGTTCATAGG
AGATGATTTTTGAGGTTTGCACTCATGCAATTTGAGAACACCGTTGACAAGAAGGCTGAGTTTACATAAATGATCTAGATTGAAACTCAG
CTACCTTTCTTCCTCATGTGGTGTAATTACAGCCCTATCTGGAGACAGCGAATACAGCAAACAGATTTTATTACCTAGTTCGCTCAAACA
CTACATGAAGTTATTTTAGTTAAAGCCCTCCCCCAAAAGTTATAAAACCATTTTATCAGGGCCCAACATGTGGCATGCAATGAAGAGAAA
ATGTAAAGCTACAGAGGTTAATGTATTGTATTATAAAATATTTTAAGTGTACTCAAAATATCATAATTGTACAGTTTATGCCACCATAAT
TTGAGGCCTATAGATTTAGCTTAAGAGAACACTGTTCTGTTTGAAATGCTTTCTGTCACTGAAATTGGCTTAATTAGTAACCATGGATAA
GATGCTTTAGATCAGACTAGGTTTTAATCATTAACTTCCACAAAGAAGTCATACTTTGCGTTAGGTGTGCTGGTTGGATGTGCAGGAACT
TCAGCAAGCAGTAGGTTTTACTAAGCAGATGGTCGGGCACTGCAGGGCACCAGGCAGGATCCTAGGGCGCCTCTTATTCTGCGTTAGCAT
CTGGTTTGCTGTATGACCTTGCACAAGTCACTTCCTTCTGAGCCTCAATTTTCTCATCTGTACAATGAGATTCAAAAGTTGACCTGAAAG

>28095_28095_5_EZH1-PDSS2_EZH1_chr17_40879653_ENST00000585893_PDSS2_chr6_107595431_ENST00000369037_length(amino acids)=252AA_BP=
MAEITELIHIALLVHRGIVNLNELQSSDGPLKDMQFGNKIAILSGDFLLANACNGLALLQNTKVVELLASALMDLVQGVYHENSTSKESY
ITDDIGISTWKEQTFLSHGALLAKSCQAAMELAKHDAEVQNMAFQYGKHMAMSHKINSDVQPFIKEKTSDSMTFNLNSAPVVLHQEFLGR

--------------------------------------------------------------
>28095_28095_6_EZH1-PDSS2_EZH1_chr17_40879653_ENST00000585893_PDSS2_chr6_107595431_ENST00000453874_length(transcript)=1005nt_BP=369nt
ACCCGCGGCTCGGGATGGAGGCTGGACACCTGTTCTGCTGTTGTGTCCTGCCATTCTCCTGAAGAACAGAGGCACACTGTAAAACCCAAC
ACTTCCCCTTGCATTCTATAAGATTACAGCAAGATGGAAATACCAAATCCCCCTACCTCCAAATGTATCACTTACTGGAAAAGAAAAGTG
AAATCTGAATACATGCGACTTCGACAACTTAAACGGCTTCAGGCAAATATGGGTGCAAAGGCTTTGTATGTGGCAAATTTTGCAAAGGTT
CAAGAAAAAACCCAGATCCTCAATGAAGAATGGAAGAAGCTTCGTGTCCAACCTGTTCAGTCAATGAAGCCTGTGAGTGGACACCCTTTT
CTCAAAAAGTCAAAGAAGTTTGGCAGAGATCACGGAGCTAATTCATATTGCTCTCCTTGTACATCGTGGGATAGTAAATTTAAATGAGTT
GCAATCATCTGATGGTCCACTGAAAGACATGCAATTTGGAAATAAAATTGCTATCCTGAGTGGAGACTTTCTTCTAGCAAATGCCTGCAA
TGGACTAGCTCTGCTACAGAACACCAAGGTTGTGGAACTTTTAGCAAGTGCTCTTATGGACTTGGTACAAGGAGTATATCATGAAAATTC
TACTTCAAAGGCTCAAGAAAAAGGAAGATTGGACTATGCTAAGTTGCGAGAAAGAATCAAAGCTGGCAAAGGTGTGACTTCAGCTATTGA
CCTGTGTCGTTACCATGGAAACAAGGCACTGGAGGCCCTGGAGAGCTTTCCTCCCTCGGAGGCCAGATCTGCTTTAGAAAACATTGTGTT
TGCTGTGACCAGATTTTCATGACATCAAATTAAAAAGACACTATTGTTAGTTAGCTGAAAATCCTAGGGAATGAGGTTGATTGGGAGCGC
TTTCACGATGCGTTAATGACTTTTAAAACATATGCATTTTTCCTTCCTTTTATCACATTGCTAAATGAGTTCTGCTTTCTTTTTGGAACT

>28095_28095_6_EZH1-PDSS2_EZH1_chr17_40879653_ENST00000585893_PDSS2_chr6_107595431_ENST00000453874_length(amino acids)=150AA_BP=
MAEITELIHIALLVHRGIVNLNELQSSDGPLKDMQFGNKIAILSGDFLLANACNGLALLQNTKVVELLASALMDLVQGVYHENSTSKAQE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for EZH1-PDSS2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for EZH1-PDSS2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for EZH1-PDSS2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource