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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:EZH2-ZNF746 (FusionGDB2 ID:28107)

Fusion Gene Summary for EZH2-ZNF746

check button Fusion gene summary
Fusion gene informationFusion gene name: EZH2-ZNF746
Fusion gene ID: 28107
HgeneTgene
Gene symbol

EZH2

ZNF746

Gene ID

2146

155061

Gene nameenhancer of zeste 2 polycomb repressive complex 2 subunitzinc finger protein 746
SynonymsENX-1|ENX1|EZH2b|KMT6|KMT6A|WVS|WVS2PARIS
Cytomap

7q36.1

7q36.1

Type of geneprotein-codingprotein-coding
Descriptionhistone-lysine N-methyltransferase EZH2enhancer of zeste homolog 2lysine N-methyltransferase 6zinc finger protein 746parkin-interacting substrateparkin-interacting sustrate
Modification date2020032920200313
UniProtAcc

Q15910

.
Ensembl transtripts involved in fusion geneENST00000536783, ENST00000320356, 
ENST00000350995, ENST00000460911, 
ENST00000476773, ENST00000478654, 
ENST00000483967, ENST00000541220, 
ENST00000340622, ENST00000458143, 
ENST00000461958, 
Fusion gene scores* DoF score9 X 9 X 5=4051 X 1 X 1=1
# samples 91
** MAII scorelog2(9/405*10)=-2.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context

PubMed: EZH2 [Title/Abstract] AND ZNF746 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointEZH2(148543561)-ZNF746(149191594), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneEZH2

GO:0000122

negative regulation of transcription by RNA polymerase II

20154697

HgeneEZH2

GO:0010718

positive regulation of epithelial to mesenchymal transition

20154697

HgeneEZH2

GO:0043406

positive regulation of MAP kinase activity

20154697

HgeneEZH2

GO:0043547

positive regulation of GTPase activity

20154697

HgeneEZH2

GO:0045814

negative regulation of gene expression, epigenetic

20154697

HgeneEZH2

GO:0070734

histone H3-K27 methylation

24474760

HgeneEZH2

GO:0071902

positive regulation of protein serine/threonine kinase activity

20154697

TgeneZNF746

GO:0000122

negative regulation of transcription by RNA polymerase II

21376232

TgeneZNF746

GO:0045892

negative regulation of transcription, DNA-templated

21376232

TgeneZNF746

GO:0045944

positive regulation of transcription by RNA polymerase II

21376232

TgeneZNF746

GO:1901216

positive regulation of neuron death

21376232


check buttonFusion gene breakpoints across EZH2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ZNF746 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-24-2019EZH2chr7

148543561

-ZNF746chr7

149191594

-


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Fusion Gene ORF analysis for EZH2-ZNF746

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000536783ENST00000340622EZH2chr7

148543561

-ZNF746chr7

149191594

-
5UTR-3CDSENST00000536783ENST00000458143EZH2chr7

148543561

-ZNF746chr7

149191594

-
5UTR-3CDSENST00000536783ENST00000461958EZH2chr7

148543561

-ZNF746chr7

149191594

-
In-frameENST00000320356ENST00000340622EZH2chr7

148543561

-ZNF746chr7

149191594

-
In-frameENST00000320356ENST00000458143EZH2chr7

148543561

-ZNF746chr7

149191594

-
In-frameENST00000320356ENST00000461958EZH2chr7

148543561

-ZNF746chr7

149191594

-
In-frameENST00000350995ENST00000340622EZH2chr7

148543561

-ZNF746chr7

149191594

-
In-frameENST00000350995ENST00000458143EZH2chr7

148543561

-ZNF746chr7

149191594

-
In-frameENST00000350995ENST00000461958EZH2chr7

148543561

-ZNF746chr7

149191594

-
In-frameENST00000460911ENST00000340622EZH2chr7

148543561

-ZNF746chr7

149191594

-
In-frameENST00000460911ENST00000458143EZH2chr7

148543561

-ZNF746chr7

149191594

-
In-frameENST00000460911ENST00000461958EZH2chr7

148543561

-ZNF746chr7

149191594

-
intron-3CDSENST00000476773ENST00000340622EZH2chr7

148543561

-ZNF746chr7

149191594

-
intron-3CDSENST00000476773ENST00000458143EZH2chr7

148543561

-ZNF746chr7

149191594

-
intron-3CDSENST00000476773ENST00000461958EZH2chr7

148543561

-ZNF746chr7

149191594

-
intron-3CDSENST00000478654ENST00000340622EZH2chr7

148543561

-ZNF746chr7

149191594

-
intron-3CDSENST00000478654ENST00000458143EZH2chr7

148543561

-ZNF746chr7

149191594

-
intron-3CDSENST00000478654ENST00000461958EZH2chr7

148543561

-ZNF746chr7

149191594

-
intron-3CDSENST00000483967ENST00000340622EZH2chr7

148543561

-ZNF746chr7

149191594

-
intron-3CDSENST00000483967ENST00000458143EZH2chr7

148543561

-ZNF746chr7

149191594

-
intron-3CDSENST00000483967ENST00000461958EZH2chr7

148543561

-ZNF746chr7

149191594

-
intron-3CDSENST00000541220ENST00000340622EZH2chr7

148543561

-ZNF746chr7

149191594

-
intron-3CDSENST00000541220ENST00000458143EZH2chr7

148543561

-ZNF746chr7

149191594

-
intron-3CDSENST00000541220ENST00000461958EZH2chr7

148543561

-ZNF746chr7

149191594

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000460911EZH2chr7148543561-ENST00000340622ZNF746chr7149191594-3836335892245718
ENST00000460911EZH2chr7148543561-ENST00000458143ZNF746chr7149191594-3837335892248719
ENST00000460911EZH2chr7148543561-ENST00000461958ZNF746chr7149191594-516533589874261
ENST00000350995EZH2chr7148543561-ENST00000340622ZNF746chr7149191594-3839338922248718
ENST00000350995EZH2chr7148543561-ENST00000458143ZNF746chr7149191594-3840338922251719
ENST00000350995EZH2chr7148543561-ENST00000461958ZNF746chr7149191594-516833892877261
ENST00000320356EZH2chr7148543561-ENST00000340622ZNF746chr7149191594-38693681222278718
ENST00000320356EZH2chr7148543561-ENST00000458143ZNF746chr7149191594-38703681222281719
ENST00000320356EZH2chr7148543561-ENST00000461958ZNF746chr7149191594-5198368122907261

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000460911ENST00000340622EZH2chr7148543561-ZNF746chr7149191594-0.025707870.9742921
ENST00000460911ENST00000458143EZH2chr7148543561-ZNF746chr7149191594-0.0266255140.9733744
ENST00000460911ENST00000461958EZH2chr7148543561-ZNF746chr7149191594-0.0109813220.9890187
ENST00000350995ENST00000340622EZH2chr7148543561-ZNF746chr7149191594-0.0258040260.974196
ENST00000350995ENST00000458143EZH2chr7148543561-ZNF746chr7149191594-0.026712120.97328794
ENST00000350995ENST00000461958EZH2chr7148543561-ZNF746chr7149191594-0.0109447630.9890553
ENST00000320356ENST00000340622EZH2chr7148543561-ZNF746chr7149191594-0.0250294660.97497046
ENST00000320356ENST00000458143EZH2chr7148543561-ZNF746chr7149191594-0.0258837980.97411627
ENST00000320356ENST00000461958EZH2chr7148543561-ZNF746chr7149191594-0.0108201730.98917985

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Fusion Genomic Features for EZH2-ZNF746


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for EZH2-ZNF746


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:148543561/chr7:149191594)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EZH2

Q15910

.
FUNCTION: Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Displays a preference for substrates with less methylation, loses activity when progressively more methyl groups are incorporated into H3K27, H3K27me0 > H3K27me1 > H3K27me2 (PubMed:22323599, PubMed:30923826). Compared to EZH1-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1, CDKN2A and retinoic acid target genes. EZH2 can also methylate non-histone proteins such as the transcription factor GATA4 and the nuclear receptor RORA. Regulates the circadian clock via histone methylation at the promoter of the circadian genes. Essential for the CRY1/2-mediated repression of the transcriptional activation of PER1/2 by the CLOCK-ARNTL/BMAL1 heterodimer; involved in the di and trimethylation of 'Lys-27' of histone H3 on PER1/2 promoters which is necessary for the CRY1/2 proteins to inhibit transcription. {ECO:0000269|PubMed:14532106, ECO:0000269|PubMed:15225548, ECO:0000269|PubMed:15231737, ECO:0000269|PubMed:15385962, ECO:0000269|PubMed:16179254, ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:16618801, ECO:0000269|PubMed:16717091, ECO:0000269|PubMed:16936726, ECO:0000269|PubMed:17210787, ECO:0000269|PubMed:17344414, ECO:0000269|PubMed:18285464, ECO:0000269|PubMed:19026781, ECO:0000269|PubMed:20935635, ECO:0000269|PubMed:22323599, ECO:0000269|PubMed:23063525, ECO:0000269|PubMed:24474760, ECO:0000269|PubMed:30923826}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneZNF746chr7:148543561chr7:149191594ENST000003406220716_928645.0Coiled coilOntology_term=ECO:0000255
TgeneZNF746chr7:148543561chr7:149191594ENST000004581430716_928646.0Coiled coilOntology_term=ECO:0000255
TgeneZNF746chr7:148543561chr7:149191594ENST0000034062207476_5168645.0Compositional biasNote=Gly-rich
TgeneZNF746chr7:148543561chr7:149191594ENST0000045814307476_5168646.0Compositional biasNote=Gly-rich
TgeneZNF746chr7:148543561chr7:149191594ENST000003406220796_1678645.0DomainKRAB
TgeneZNF746chr7:148543561chr7:149191594ENST000004581430796_1678646.0DomainKRAB
TgeneZNF746chr7:148543561chr7:149191594ENST0000034062207453_4788645.0Zinc fingerC2H2-type 1%3B degenerate
TgeneZNF746chr7:148543561chr7:149191594ENST0000034062207510_5328645.0Zinc fingerC2H2-type 2
TgeneZNF746chr7:148543561chr7:149191594ENST0000034062207538_5608645.0Zinc fingerC2H2-type 3
TgeneZNF746chr7:148543561chr7:149191594ENST0000034062207566_5888645.0Zinc fingerC2H2-type 4
TgeneZNF746chr7:148543561chr7:149191594ENST0000045814307453_4788646.0Zinc fingerC2H2-type 1%3B degenerate
TgeneZNF746chr7:148543561chr7:149191594ENST0000045814307510_5328646.0Zinc fingerC2H2-type 2
TgeneZNF746chr7:148543561chr7:149191594ENST0000045814307538_5608646.0Zinc fingerC2H2-type 3
TgeneZNF746chr7:148543561chr7:149191594ENST0000045814307566_5888646.0Zinc fingerC2H2-type 4

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEZH2chr7:148543561chr7:149191594ENST00000320356-320523_60582752.0Compositional biasNote=Cys-rich
HgeneEZH2chr7:148543561chr7:149191594ENST00000350995-319523_60582708.0Compositional biasNote=Cys-rich
HgeneEZH2chr7:148543561chr7:149191594ENST00000460911-320523_60582747.0Compositional biasNote=Cys-rich
HgeneEZH2chr7:148543561chr7:149191594ENST00000476773-119523_6050696.0Compositional biasNote=Cys-rich
HgeneEZH2chr7:148543561chr7:149191594ENST00000478654-120523_6050696.0Compositional biasNote=Cys-rich
HgeneEZH2chr7:148543561chr7:149191594ENST00000483967-120523_6050738.0Compositional biasNote=Cys-rich
HgeneEZH2chr7:148543561chr7:149191594ENST00000541220-119523_6050696.0Compositional biasNote=Cys-rich
HgeneEZH2chr7:148543561chr7:149191594ENST00000320356-320503_60582752.0DomainCXC
HgeneEZH2chr7:148543561chr7:149191594ENST00000320356-320612_72782752.0DomainSET
HgeneEZH2chr7:148543561chr7:149191594ENST00000350995-319503_60582708.0DomainCXC
HgeneEZH2chr7:148543561chr7:149191594ENST00000350995-319612_72782708.0DomainSET
HgeneEZH2chr7:148543561chr7:149191594ENST00000460911-320503_60582747.0DomainCXC
HgeneEZH2chr7:148543561chr7:149191594ENST00000460911-320612_72782747.0DomainSET
HgeneEZH2chr7:148543561chr7:149191594ENST00000476773-119503_6050696.0DomainCXC
HgeneEZH2chr7:148543561chr7:149191594ENST00000476773-119612_7270696.0DomainSET
HgeneEZH2chr7:148543561chr7:149191594ENST00000478654-120503_6050696.0DomainCXC
HgeneEZH2chr7:148543561chr7:149191594ENST00000478654-120612_7270696.0DomainSET
HgeneEZH2chr7:148543561chr7:149191594ENST00000483967-120503_6050738.0DomainCXC
HgeneEZH2chr7:148543561chr7:149191594ENST00000483967-120612_7270738.0DomainSET
HgeneEZH2chr7:148543561chr7:149191594ENST00000541220-119503_6050696.0DomainCXC
HgeneEZH2chr7:148543561chr7:149191594ENST00000541220-119612_7270696.0DomainSET


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Fusion Gene Sequence for EZH2-ZNF746


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>28107_28107_1_EZH2-ZNF746_EZH2_chr7_148543561_ENST00000320356_ZNF746_chr7_149191594_ENST00000340622_length(transcript)=3869nt_BP=368nt
TCCGGTCGCGTCCGACACCCGGTGGGACTCAGAAGGCAGTGGAGCCCCGGCGGCGGCGGCGGCGGCGCGCGGGGGCGACGCGCGGGAACA
ACGCGAGTCGGCGCGCGGGACGAAGAATAATCATGGGCCAGACTGGGAAGAAATCTGAGAAGGGACCAGTTTGTTGGCGGAAGCGTGTAA
AATCAGAGTACATGCGACTGAGACAGCTCAAGAGGTTCAGACGAGCTGATGAAGTAAAGAGTATGTTTAGTTCCAATCGTCAGAAAATTT
TGGAAAGAACGGAAATCTTAAACCAAGAATGGAAACAGCGAAGGATACAGCCTGTGCACATCCTGACTTCTGTGAGCTCATTGCGCGGGA
CTAGGGAGATTTCTCCGTGGACGATGGCAGCCACGATTCAGGCCATGGAGAGGAAGATTGAATCGCAGGCTGCTCGCCTGCTTTCCCTAG
AAGGTCGAACCGGGATGGCCGAGAAGAAGCTGGCTGATTGCGAGAAGACAGCCGTGGAGTTCGGGAACCAGCTGGAGGGCAAGTGGGCCG
TGCTGGGGACCCTGCTGCAGGAGTACGGGCTGCTGCAGAGGCGGCTGGAGAACGTGGAGAACCTGCTGCGCAACAGGAACTTCTGGATCC
TGCGGCTGCCCCCGGGCAGCAAGGGGGAGTCCCCTAAGGAGTGGGGCAAGCTGGAGGACTGGCAGAAGGAGCTCTACAAGCACGTGATGA
GGGGCAACTACGAGACGCTGGTCTCCCTGGACTACGCCATCTCCAAGCCCGAGGTCCTCTCCCAGATTGAACAAGGGAAGGAGCCCTGCA
ACTGGCGCCGCCCTGGCCCCAAGATTCCAGATGTTCCTGTGGACCCCAGTCCAGGCTCGGGGCCCCCAGTTCCCGCCCCAGACCTCTTGA
TGCAGATCAAGCAGGAGGGTGAGCTCCAGCTCCAGGAGCAGCAGGCCCTGGGCGTGGAGGCGTGGGCAGCCGGGCAGCCAGATATTGGGG
AGGAGCCCTGGGGCCTCAGCCAGCTGGATTCCGGAGCAGGAGACATCTCCACGGATGCCACCTCTGGTGTCCATTCCAACTTTTCCACCA
CCATCCCGCCCACCTCCTGGCAAACGGATCTCCCTCCCCACCATCCCTCTTCAGCATGCTCGGACGGGACCCTGAAGCTCAACACAGCAG
CCTCCACGGAAGATGTAAAAATTGTAATAAAAACAGAAGTCCAGGAAGAGGAGGTGGTGGCCACACCCGTACATCCTACTGACCTAGAGG
CTCACGGGACCCTGTTTGGACCAGGCCAAGCCACACGGTTCTTCCCTAGTCCTGCCCAGGAAGGAGCCTGGGAAAGCCAGGGCAGCTCCT
TCCCCAGCCAGGACCCTGTGCTGGGGCTGCGAGAGCCCGCCCGGCCTGAGAGGGACATGGGTGAGCTCAGTCCTGCTGTGGCCCAGGAGG
AGACCCCTCCTGGGGACTGGCTCTTCGGAGGGGTCCGGTGGGGCTGGAATTTCCGGTGTAAACCGCCAGTGGGCCTGAACCCGAGGACGG
GGCCCGAGGGGCTTCCTTACTCCTCCCCGGACAACGGAGAGGCCATCTTGGACCCCAGCCAGGCCCCAAGGCCATTCAACGAACCCTGTA
AATACCCTGGCCGGACCAAAGGCTTTGGCCACAAGCCAGGGCTGAAGAAGCACCCCGCGGCGCCCCCCGGGGGCCGGCCCTTCACCTGCG
CCACGTGTGGGAAGAGCTTCCAGCTGCAAGTCAGCCTGAGCGCGCACCAGCGCAGCTGTGGGGCGCCCGACGGGTCGGGCCCGGGCACAG
GCGGTGGCGGCAGCGGCAGTGGCGGCGGCGGTGGCGGCAGCGGTGGGGGCAGCGCACGGGATGGCAGCGCCCTTCGGTGTGGGGAGTGCG
GCCGTTGCTTCACGCGCCCCGCGCACCTCATCCGCCATCGCATGCTGCACACCGGCGAGCGGCCCTTCCCCTGCACCGAGTGTGAGAAGC
GCTTCACCGAACGCTCCAAGCTCATCGACCACTACCGAACGCACACGGGCGTGCGGCCCTTCACCTGCACCGTCTGCGGCAAAAGCTTCA
TCCGCAAGGACCACCTCCGCAAGCACCAGCGCAACCATGCAGCGGGCGCCAAGACCCCGGCCCGAGGCCAGCCACTCCCGACGCCGCCCG
CACCTCCTGATCCCTTCAAGAGCCCCGCCTCCAAAGGACCTTTGGCCTCCACAGACCTTGTGACCGACTGGACTTGTGGCCTCAGCGTCC
TGGGACCCACCGATGGCGGGGACATGTGAGCGCCTCCAGCCCCATAGCCCCTGCCGGCCGCACGTGTAAAAAGCCCCGTGTGCAGGCAGC
AGGGCGGCGTGGAAGCTTCAGGCAGACGCGGGACGGGGAGAACCAAATGTCCAAGTTGCTGAACTGATGATCACTGGAGAAAGAGAAACT
ATCCACCAGGACAGCTGCCACCTCTAAACCAAGTAGAATTCTCTGTGAAATGGGAGCGCCGTAGAATTTTAAGTAATTTAATTGCAAACC
TGTTTTGTTTTTTGTTTTTTGTTTTTTTTTAATTCTTGAGGAAAAAGCTGGAAAATAGTAATAGGGCTATTTAAATTTTGTAGGTACTTT
TGGTTTTCAGGGCGTGCATTTCTGTCACTATCTCACTGAGTCTGATAGTGTGTTGGAAGGTTGGCCAGTTGGGGACCCCTGGCCCACTGA
CTCCTGGGGATGGGGTCCTGTGTGTGCCCCTGCTCTGCCCAGTTGGGCTGAGTGGGCCTAGCGCACCAAGCCCCTGGGCAGTGAGGGCCA
TTGGGTCCCTTGGAGCACACCTCAGTGCAGCAGGAAGGACCCCTCCGGGAGTAGCGGTTGCATTTCCCAGCTTGCCTCTCCTGAAAAGGC
CCCCCAAAAGTGCTGGCCCCAACTTTTCTCTATTTTGGGCCATCTGTGGTACCCGTCCCAAGGGCACTTGGTGGTGTCCCCTAGTGTGTG
ACTCCCTGGCCTCATAAGGACGAGTTGTCTGAAATCCCAGCGTTAGGTCTGGGGAGATGGAGAAGCTGAAACTGGGGAGCTGCACCACAA
ACGTCTAGCTCTCAGCAGAGCTGGGAGCAAAGCCTGGCCGCCCACCCCAACCTGGGGCTGCCTCCCACTCCGTGAGATGCTTCTGTCTCC
TGTTCACTTTGTGTGGTAGTTTCTTATTTTCAAAATGCATCTCATTTGATCATTACTGTGACCTTGGGAAGCAGCAGGACAGGGATTTCT
TTTTAGAGGTGCAAACTGCTCAGAGGGGACACACCTCAGCCTCTCACTGTGGGTACACGTGGCGTGCCATGAGTGGGGAAGAGCAACAGG
CGAGATGCCTCATTCTACTGGAACATCACTGTGGGTGAACAGAGATTTCCAGGTTTTCCCTCTTAAAATATTTGTCCCACACCGACAAGA
GTCCAGTCACCAGGCCTCAAAGGAACTTCTGCTTGTAGCAGCCGCCTCCCCTGTGCCCCAGCCTCCTTAATGTGTGCACTCTCAGAGGGC
ACAGCTCGCGAGGCTGGGTTTGGGGGCCAAGTGGCTTGTTCATTCCAGCATCTAACATCATAAAGGTGGGCCCAGATTTCTTGATTCGAC
CACAGTGCTGTTCCTACCACACAAATATCCATTCCTGTTTTGTTGAAGCAGCCACTGGTCCTCTTGTTTCCCCTGCAGACGGAGGGACCT
GGCAGTGCCCATTCATTCAGCCCCCTCATGCATACTTTTATTAGGCGATAGACTAGTTAAGAAAATTGTTTCTATGTACTGTATATTTTG

>28107_28107_1_EZH2-ZNF746_EZH2_chr7_148543561_ENST00000320356_ZNF746_chr7_149191594_ENST00000340622_length(amino acids)=718AA_BP=563
MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEWKQRRIQPVHILTSVSSLRGTREISPWTMAA
TIQAMERKIESQAARLLSLEGRTGMAEKKLADCEKTAVEFGNQLEGKWAVLGTLLQEYGLLQRRLENVENLLRNRNFWILRLPPGSKGES
PKEWGKLEDWQKELYKHVMRGNYETLVSLDYAISKPEVLSQIEQGKEPCNWRRPGPKIPDVPVDPSPGSGPPVPAPDLLMQIKQEGELQL
QEQQALGVEAWAAGQPDIGEEPWGLSQLDSGAGDISTDATSGVHSNFSTTIPPTSWQTDLPPHHPSSACSDGTLKLNTAASTEDVKIVIK
TEVQEEEVVATPVHPTDLEAHGTLFGPGQATRFFPSPAQEGAWESQGSSFPSQDPVLGLREPARPERDMGELSPAVAQEETPPGDWLFGG
VRWGWNFRCKPPVGLNPRTGPEGLPYSSPDNGEAILDPSQAPRPFNEPCKYPGRTKGFGHKPGLKKHPAAPPGGRPFTCATCGKSFQLQV
SLSAHQRSCGAPDGSGPGTGGGGSGSGGGGGGSGGGSARDGSALRCGECGRCFTRPAHLIRHRMLHTGERPFPCTECEKRFTERSKLIDH

--------------------------------------------------------------
>28107_28107_2_EZH2-ZNF746_EZH2_chr7_148543561_ENST00000320356_ZNF746_chr7_149191594_ENST00000458143_length(transcript)=3870nt_BP=368nt
TCCGGTCGCGTCCGACACCCGGTGGGACTCAGAAGGCAGTGGAGCCCCGGCGGCGGCGGCGGCGGCGCGCGGGGGCGACGCGCGGGAACA
ACGCGAGTCGGCGCGCGGGACGAAGAATAATCATGGGCCAGACTGGGAAGAAATCTGAGAAGGGACCAGTTTGTTGGCGGAAGCGTGTAA
AATCAGAGTACATGCGACTGAGACAGCTCAAGAGGTTCAGACGAGCTGATGAAGTAAAGAGTATGTTTAGTTCCAATCGTCAGAAAATTT
TGGAAAGAACGGAAATCTTAAACCAAGAATGGAAACAGCGAAGGATACAGCCTGTGCACATCCTGACTTCTGTGAGCTCATTGCGCGGGA
CTAGGGAGATTTCTCCGTGGACGATGGCAGCCACGATTCAGGCCATGGAGAGGAAGATTGAATCGCAGGCTGCTCGCCTGCTTTCCCTAG
AAGGTCGAACCGGGATGGCCGAGAAGAAGCTGGCTGATTGCGAGAAGACAGCCGTGGAGTTCGGGAACCAGCTGGAGGGCAAGTGGGCCG
TGCTGGGGACCCTGCTGCAGGAGTACGGGCTGCTGCAGAGGCGGCTGGAGAACGTGGAGAACCTGCTGCGCAACAGGAACTTCTGGATCC
TGCGGCTGCCCCCGGGCAGCAAGGGGGAGTCCCCTAAGGAGTGGGGCAAGCTGGAGGACTGGCAGAAGGAGCTCTACAAGCACGTGATGA
GGGGCAACTACGAGACGCTGGTCTCCCTGGACTACGCCATCTCCAAGCCCGAGGTCCTCTCCCAGATTGAACAAGGGAAGGAGCCCTGCA
ACTGGCGCCGCCCTGGCCCCAAGATTCCAGATGTTCCTGTGGACCCCAGTCCAGGCTCGGGGCCCCCAGTTCCCGCCCCAGACCTCTTGA
TGCAGATCAAGCAGGAGGGTGAGCTCCAGCTCCAGGAGCAGCAGGCCCTGGGCGTGGAGGCGTGGGCAGCCGGGCAGCCAGATATTGGGG
AGGAGCCCTGGGGCCTCAGCCAGCTGGATTCCGGAGCAGGAGACATCTCCACGGATGCCACCTCTGGTGTCCATTCCAACTTTTCCACCA
CCATCCCGCCCACCTCCTGGCAAACGGATCTCCCTCCCCACCATCCCTCTTCAGCATGCTCGGACGGGACCCTGAAGCTCAACACAGCAG
CCTCCACGGAAGCAGATGTAAAAATTGTAATAAAAACAGAAGTCCAGGAAGAGGAGGTGGTGGCCACACCCGTACATCCTACTGACCTAG
AGGCTCACGGGACCCTGTTTGGACCAGGCCAAGCCACACGGTTCTTCCCTAGTCCTGCCCAGGAAGGAGCCTGGGAAAGCCAGGGCAGCT
CCTTCCCCAGCCAGGACCCTGTGCTGGGGCTGCGAGAGCCCGCCCGGCCTGAGAGGGACATGGGTGAGCTCAGTCCTGCTGTGGCCCAGG
AGGAGACCCCTCCTGGGGACTGGCTCTTCGGAGGGGTCCGGTGGGGCTGGAATTTCCGGTGTAAACCGCCAGTGGGCCTGAACCCGAGGA
CGGGGCCCGAGGGGCTTCCTTACTCCTCCCCGGACAACGGAGAGGCCATCTTGGACCCCAGCCAGGCCCCAAGGCCATTCAACGAACCCT
GTAAATACCCTGGCCGGACCAAAGGCTTTGGCCACAAGCCAGGGCTGAAGAAGCACCCCGCGGCGCCCCCCGGGGGCCGGCCCTTCACCT
GCGCCACGTGTGGGAAGAGCTTCCAGCTGCAAGTCAGCCTGAGCGCGCACCAGCGCAGCTGTGGGGCGCCCGACGGGTCGGGCCCGGGCA
CAGGCGGTGGCGGCAGCGGCAGTGGCGGCGGCGGTGGCGGCAGCGGTGGGGGCAGCGCACGGGATGGCAGCGCCCTTCGGTGTGGGGAGT
GCGGCCGTTGCTTCACGCGCCCCGCGCACCTCATCCGCCATCGCATGCTGCACACCGGCGAGCGGCCCTTCCCCTGCACCGAGTGTGAGA
AGCGCTTCACCGAACGCTCCAAGCTCATCGACCACTACCGAACGCACACGGGCGTGCGGCCCTTCACCTGCACCGTCTGCGGCAAAAGCT
TCATCCGCAAGGACCACCTCCGCAAGCACCAGCGCAACCATGCAGCGGGCGCCAAGACCCCGGCCCGAGGCCAGCCACTCCCGACGCCGC
CCGCACCTCCTGATCCCTTCAAGAGCCCCGCCTCCAAAGGACCTTTGGCCTCCACAGACCTTGTGACCGACTGGACTTGTGGCCTCAGCG
TCCTGGGACCCACCGATGGCGGGGACATGTGAGCGCCTCCAGCCCCATAGCCCCTGCCGGCCGCACGTGTAAAAAGCCCCGTGTGCAGGC
AGCAGGGCGGCGTGGAAGCTTCAGGCAGACGCGGGACGGGGAGAACCAAATGTCCAAGTTGCTGAACTGATGATCACTGGAGAAAGAGAA
ACTATCCACCAGGACAGCTGCCACCTCTAAACCAAGTAGAATTCTCTGTGAAATGGGAGCGCCGTAGAATTTTAAGTAATTTAATTGCAA
ACCTGTTTTGTTTTTTGTTTTTTGTTTTTTTTTAATTCTTGAGGAAAAAGCTGGAAAATAGTAATAGGGCTATTTAAATTTTGTAGGTAC
TTTTGGTTTTCAGGGCGTGCATTTCTGTCACTATCTCACTGAGTCTGATAGTGTGTTGGAAGGTTGGCCAGTTGGGGACCCCTGGCCCAC
TGACTCCTGGGGATGGGGTCCTGTGTGTGCCCCTGCTCTGCCCAGTTGGGCTGAGTGGGCCTAGCGCACCAAGCCCCTGGGCAGTGAGGG
CCATTGGGTCCCTTGGAGCACACCTCAGTGCAGCAGGAAGGACCCCTCCGGGAGTAGCGGTTGCATTTCCCAGCTTGCCTCTCCTGAAAA
GGCCCCCCAAAAGTGCTGGCCCCAACTTTTCTCTATTTTGGGCCATCTGTGGTACCCGTCCCAAGGGCACTTGGTGGTGTCCCCTAGTGT
GTGACTCCCTGGCCTCATAAGGACGAGTTGTCTGAAATCCCAGCGTTAGGTCTGGGGAGATGGAGAAGCTGAAACTGGGGAGCTGCACCA
CAAACGTCTAGCTCTCAGCAGAGCTGGGAGCAAAGCCTGGCCGCCCACCCCAACCTGGGGCTGCCTCCCACTCCGTGAGATGCTTCTGTC
TCCTGTTCACTTTGTGTGGTAGTTTCTTATTTTCAAAATGCATCTCATTTGATCATTACTGTGACCTTGGGAAGCAGCAGGACAGGGATT
TCTTTTTAGAGGTGCAAACTGCTCAGAGGGGACACACCTCAGCCTCTCACTGTGGGTACACGTGGCGTGCCATGAGTGGGGAAGAGCAAC
AGGCGAGATGCCTCATTCTACTGGAACATCACTGTGGGTGAACAGAGATTTCCAGGTTTTCCCTCTTAAAATATTTGTCCCACACCGACA
AGAGTCCAGTCACCAGGCCTCAAAGGAACTTCTGCTTGTAGCAGCCGCCTCCCCTGTGCCCCAGCCTCCTTAATGTGTGCACTCTCAGAG
GGCACAGCTCGCGAGGCTGGGTTTGGGGGCCAAGTGGCTTGTTCATTCCAGCATCTAACATCATAAAGGTGGGCCCAGATTTCTTGATTC
GACCACAGTGCTGTTCCTACCACACAAATATCCATTCCTGTTTTGTTGAAGCAGCCACTGGTCCTCTTGTTTCCCCTGCAGACGGAGGGA
CCTGGCAGTGCCCATTCATTCAGCCCCCTCATGCATACTTTTATTAGGCGATAGACTAGTTAAGAAAATTGTTTCTATGTACTGTATATT
TTGTACCTGTTTACACTTCTAATATTGATATAACTGATATTTTGAAAAATAAGAGAAAACATCCTGTTAAAATAAAACCTAACCAGCACC

>28107_28107_2_EZH2-ZNF746_EZH2_chr7_148543561_ENST00000320356_ZNF746_chr7_149191594_ENST00000458143_length(amino acids)=719AA_BP=564
MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEWKQRRIQPVHILTSVSSLRGTREISPWTMAA
TIQAMERKIESQAARLLSLEGRTGMAEKKLADCEKTAVEFGNQLEGKWAVLGTLLQEYGLLQRRLENVENLLRNRNFWILRLPPGSKGES
PKEWGKLEDWQKELYKHVMRGNYETLVSLDYAISKPEVLSQIEQGKEPCNWRRPGPKIPDVPVDPSPGSGPPVPAPDLLMQIKQEGELQL
QEQQALGVEAWAAGQPDIGEEPWGLSQLDSGAGDISTDATSGVHSNFSTTIPPTSWQTDLPPHHPSSACSDGTLKLNTAASTEADVKIVI
KTEVQEEEVVATPVHPTDLEAHGTLFGPGQATRFFPSPAQEGAWESQGSSFPSQDPVLGLREPARPERDMGELSPAVAQEETPPGDWLFG
GVRWGWNFRCKPPVGLNPRTGPEGLPYSSPDNGEAILDPSQAPRPFNEPCKYPGRTKGFGHKPGLKKHPAAPPGGRPFTCATCGKSFQLQ
VSLSAHQRSCGAPDGSGPGTGGGGSGSGGGGGGSGGGSARDGSALRCGECGRCFTRPAHLIRHRMLHTGERPFPCTECEKRFTERSKLID

--------------------------------------------------------------
>28107_28107_3_EZH2-ZNF746_EZH2_chr7_148543561_ENST00000320356_ZNF746_chr7_149191594_ENST00000461958_length(transcript)=5198nt_BP=368nt
TCCGGTCGCGTCCGACACCCGGTGGGACTCAGAAGGCAGTGGAGCCCCGGCGGCGGCGGCGGCGGCGCGCGGGGGCGACGCGCGGGAACA
ACGCGAGTCGGCGCGCGGGACGAAGAATAATCATGGGCCAGACTGGGAAGAAATCTGAGAAGGGACCAGTTTGTTGGCGGAAGCGTGTAA
AATCAGAGTACATGCGACTGAGACAGCTCAAGAGGTTCAGACGAGCTGATGAAGTAAAGAGTATGTTTAGTTCCAATCGTCAGAAAATTT
TGGAAAGAACGGAAATCTTAAACCAAGAATGGAAACAGCGAAGGATACAGCCTGTGCACATCCTGACTTCTGTGAGCTCATTGCGCGGGA
CTAGGGAGATTTCTCCGTGGACGATGGCAGCCACGATTCAGGCCATGGAGAGGAAGATTGAATCGCAGGCTGCTCGCCTGCTTTCCCTAG
AAGGTCGAACCGGGATGGCCGAGAAGAAGCTGGCTGATTGCGAGAAGACAGCCGTGGAGTTCGGGAACCAGCTGGAGGGCAAGTGGGCCG
TGCTGGGGACCCTGCTGCAGGAGTACGGGCTGCTGCAGAGGCGGCTGGAGAACGTGGAGAACCTGCTGCGCAACAGGAACTTCTGGATCC
TGCGGCTGCCCCCGGGCAGCAAGGGGGAGTCCCCTAAGGAGTGGGGCAAGCTGGAGGACTGGCAGAAGGAGCTCTACAAGCACGTGATGA
GGGGCAACTACGAGACGCTGGTCTCCCTGGACTACGCCATCTCCAAGCCCGAGGTCCTCTCCCAGATTGAACAAGGGAAGGAGCCCTGCA
ACTGGCGCCGCCCTGGCCCCAAGATTCCAGATGTTCCTGTGGACCCCAGTCCAGATATCAGCGTCTCAGATTTCCCTGGAGCCAGTCAGC
ACCTTTGAAAGTTAAGGGAAGGACAGGTGGACACAGGAGAAAAACCAAATTCCTAAAGTGAAGACCTGCTGGGTCATTTGACTAGGGAGA
CCACATCTCTGCAAGGCTCGACCCCTGATTCCTCCAGAAGACCCGCCCTTGACCGTCCCACCTGCCTTGGTTTTCCCTTTCGTCTGACAC
TGAGAAAGGTGGTGGTCCGCAGAGGCCCTCCTGTGCGCCACTTGTGTGAAATTAAATGCATCCCCCATGTTCGTCATCTCATCTCAGTCA
GATTTGCACTTTCCTAAGGGCAGAAGCATGTTCCGGGCTGGCCGCTTTGCCAGTCGTCATCGGGACATTGACAGTTTAGCTCTACAGATG
CATTTTTAAGAATCTTCTAGGCGTCAAGGACAGTGCTGAACACTAGAGGACAGAAAGATGGCTGAGAACAGATACTATTGGGCTGGAAAA
GAGGGTTACAACCCGTGCGCGTCCCCAGCTTCCTAGCCTGGGTGGGAGGTTCTGGGTGGGTGGGTTTCGTTGTATTTACACCATGTGTGG
AGGCTTCCCTCACTTCCACAGCATCATTCAATGAGAGTAAAGAGGGGCTGGAAATACGCTGGTTGCTGGTAAGACCCTGTAACACTCTCT
AGCTGCACCGTATGATGTTCAGCAGCATCCGTGGCCTCTACCCACCAGTAGACAAGATGAGTAGACACAAACTCCACTGTCCATCCTGAG
CCTGTTGGCAGGGATCTGTGTGGCGTTTATCCCTGTCCCCTTTGTCTGAGAAGCCAGGACTCCCAGCTCATCCCTTGCCACATTTGGCCT
GACCCATCCCCTTGTGAGACCTCACCTCCCCTTCTCCTCACCTCCTGCACATCCCTCCACTGAGCCTTGTGGGACTCAGGGCTCAGCAGA
CCCGCCAGGTCCTGAGTGTTCCCTGCTCGGACTGAGCTCCAGGGGACTGCAGCCCTCTGAGTGCTTGTCATCCTCTTCCCTGCCTCTGTC
TTGAGCCCAGGCCCACTGGGACAGGGTCCTCACCCCTCAGATTGTGCCTCTGCCAGCCTCAATCCCTCTCTAGAGACCTTGCCTTTGGGT
CCCAGGCCTTGTCTTTTTGCTACTTCTGCAGACCTTCCCTCTCTTCTCAACACTCTTCCTGCCCTCAGTCTTGGCCATGGCAGCCTCCTT
GTTGATTGTCCTGTGCCCCCCCAACCCATCCCACAGCCATCCGTGACTGTGACGACAGTGACTTTACCATACCCACCATCTCCATCTCCA
GCACACCACTCCCTGGCCGCCTCCTGCCGTCCCTTCAATTCCGTCTGGTGTCCTGATTCCAGCAGTTTTCCAGTCCTTCAAGACCTGCAA
GCCATCGACCCTGCTGCCTTTTCACTGCCCTGACTCATCCTCATTTCCCTCCATGCCCACCATTGTGGTCCCCCCTTACACACACCCTCA
GCACTCTTGCCCCTGTTTTGTTCATTGTATCCACTTAGTGAAATCCATCGGTGTTCTGCACCTGCAGCCAAGCAGCTGCACGTGGCTGCA
GAGAACCAGGTAAGCTGGCTGCTGGTGTCACGTGACATTCATGACCAGCGACTTCAGTGGGCGCTCTGCCACACAGTCACACCGTGTCTC
CTTAGCCCAGGGGCCAGCAAACTGTGGCTGAGGGCCAAACCTAGCTCATCTGTTTCTGTATGGTGCACAGCTGAGAACAGTTTTATATTT
TAACCCGTTTTTTAAAAGAGAAACGCACCACTCACACAGCCCTCTCCACGCCATCTGCCTGCACCAGTGCCCCCTTCTCTGCCTTCACTT
CTGTGACTGCTAAACTGTCAACCCTCCAGCCAAAGCCCCACTTCGATCTGGCACCAGATCCCACCTCATGCCATCTTCTCAAGGGCAATA
CAAGCAATCCTGCCTTGACCTCTACCCCGGCAGCCACTGCCCGCTTGTCTGTTCCCCTTTGTGGCAGAGCCCTTGGGGACATCTGCGCTT
GCTGTCTCCTGCACCTTCCCCCCCACTCTGTTACCCCTTCCACCAAAACCTCTCCAACCTCGGTTACCAGGGCCCTCCGTGGTCCTGAAT
GGTCTGTCTTCTTACTTGGCCTTGTCCCCTCTACTCTGCCACGTAGGCCCGTCATCTCCTGCCAGCCCCTCTCCTCCTGCCCTGATCCCC
CAGTCTTGCCTCAGCCCAGCAGAGTAATCCCTTTTAGACCCAAGTCCTGGCTTTCCATCTGACCCGCACCGTCAGCTCACCACCTCCACT
TTTCTCTCACTCTGCCCAGCTGCAGAGTGCTGTTCCCTGGTGCTGTTCCCTCCGCCCTGTGCCAGGGCCTTCGCAGTGCCCTCTACTGGG
AATCCTCCTCAGGCAGGTCCCACCTGCAGGCCTTTCGTGTCATCGGCACTGCAGGCCCTCCCCACCCAGGACTCCAGGCCTACTTTCCTG
CTTTGGGTCTTCCGTGTTAGACAGTGTCACATAATATATATGTTTCCTATTTATAGATTCATCGTATGTCAGGTCTCCTCCATTAGAATG
TCAATTTCAAAAGTATAAAAATTTTTACCTGTTTAATCATTTTAGGAACCTAGAGTATTGCCTAGTACAGAGTAGGAATTCAATAACTAT
TTGCTGAATGTATGCTGTTTCAAAATTTAAAACGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGAAATAATGTATTTCTG
ATAGCATTTAAATTCCTTTTTAGGTCTCCCAGGCCTCCCTAGGAATTTTCTGTTTATTCTTTCTATCCACATTTTAAAACGTCTGCTGTG
TACTTTGGTAGCTGTAAACAATATATAATACGGTTTTTTGTGTTCTGAAAAATTACATAGATGTCATTATATTTATCACTCATTATTCTG
TATTTCAGACTTATCCATGTTGATACATGTAGATCAAGTTCATTCCTTTTAACAGATGCTTAATATTCCAGAAGCAACTATATTGTAACT
TATTTTCCATTCCTCCACTGATTGGCACTTAAGCTTTTTCTGATTGTTCACTCTCACAAGCAATACTGTAGTGAGCGTTCTTGCGCCTGT
TTTTTTGTGGCCCTGTGGGGATGCTGCTCCAGGGAGTAGACCCAGCGGTGGCCTCACCACGTCGTAGGCTTGATTTCATCTCTTCCGTTA
CTGTATGGCCCTCCCCAGGGGTACCCAGTGCCAGCGGGTGCTCCTAGAACTTGCTTCCTAACGTCTGCCCAGTTTCCATAATTACATTTT
TGCCGACCTGATGGGGGTGAGATGGCCTCTCGTTTCAACTTGTATTTTCCCCCTTAAGTTGCACGCCCTTTTTATACGATTATTTGGCTG
CTTCTCCAGTGAGTTGTCTTCTGTTTTTCTATTGAGATATTCTTCATTTTCTTCTTGATTCAGGGCTTCTTTGTATGTGTTCTAGATACA
AATCCTTTGTCTATTATTTGTGTTACAAACATTTTCTCCGTGTCGGTGGCAGGTCTTTAACGTTGTAGTTCTTGTATGGAAGTTTTCACT
GTTGAAAGAGTCAAACATGTCAGTCTTTTCCTTTATGATCTGTGCTTTTTCTGTAGTGAGATATCCTTGCTTACCTCACTCAAGGTCAGA
AAGATACTCTTCTCTATTTTTTTTATAAATTTTTAAAAGTTTTGCTTTTCAAATTTAAGTCTTTAATTTATCTAGAATTAAAATTTGTGT
AGCTTGCAAGGGAGGGTTTCAGTTTTTTCTCCCACAACGATGGTCTCATTTTCCAACAAAGTTTGCTGAATGTGTTAGCTTTTCTCCACT
GATTTGTGATGCGATTCTGTCCTGAGCTGGTTTCTGCATGTGCACAAGTCTGTTTCTGGGTGCTTGCTTCTGTGTCATTGGTCTCTTTGT
CAGTCTCTGCACCAACAGCTTGCTCTTTTAGCTTCATAATAAGCCTTGATATCTAGTAGACTAATCCTTCTCTGCTTGTTCTTCAAAAAA
CTGTCTTGGCTATTCTTGGATATTTGTTCTTTTATATGAATTTTGGGATCTGTATGTCAAGTTCCTAAGAAAATCCTGTTGGAAATTTGA
TTGGAATTGCATTGACTTTACAGTCTAATTTCTGGAGAATTGCTCTCATGACAACATTAGCCTTTCTACTCATTGGAACACTCATTTATT
GAAGGCTTCTATGTGCTTGAATAAGATTTTACAGTTTTCTTCTGATAGTTGTTTTTCATTATAAATGGGATTTTTACAGTTTATTAGATG

>28107_28107_3_EZH2-ZNF746_EZH2_chr7_148543561_ENST00000320356_ZNF746_chr7_149191594_ENST00000461958_length(amino acids)=261AA_BP=82
MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEWKQRRIQPVHILTSVSSLRGTREISPWTMAA
TIQAMERKIESQAARLLSLEGRTGMAEKKLADCEKTAVEFGNQLEGKWAVLGTLLQEYGLLQRRLENVENLLRNRNFWILRLPPGSKGES

--------------------------------------------------------------
>28107_28107_4_EZH2-ZNF746_EZH2_chr7_148543561_ENST00000350995_ZNF746_chr7_149191594_ENST00000340622_length(transcript)=3839nt_BP=338nt
AGAAGGCAGTGGAGCCCCGGCGGCGGCGGCGGCGGCGCGCGGGGGCGACGCGCGGGAACAACGCGAGTCGGCGCGCGGGACGAAGAATAA
TCATGGGCCAGACTGGGAAGAAATCTGAGAAGGGACCAGTTTGTTGGCGGAAGCGTGTAAAATCAGAGTACATGCGACTGAGACAGCTCA
AGAGGTTCAGACGAGCTGATGAAGTAAAGAGTATGTTTAGTTCCAATCGTCAGAAAATTTTGGAAAGAACGGAAATCTTAAACCAAGAAT
GGAAACAGCGAAGGATACAGCCTGTGCACATCCTGACTTCTGTGAGCTCATTGCGCGGGACTAGGGAGATTTCTCCGTGGACGATGGCAG
CCACGATTCAGGCCATGGAGAGGAAGATTGAATCGCAGGCTGCTCGCCTGCTTTCCCTAGAAGGTCGAACCGGGATGGCCGAGAAGAAGC
TGGCTGATTGCGAGAAGACAGCCGTGGAGTTCGGGAACCAGCTGGAGGGCAAGTGGGCCGTGCTGGGGACCCTGCTGCAGGAGTACGGGC
TGCTGCAGAGGCGGCTGGAGAACGTGGAGAACCTGCTGCGCAACAGGAACTTCTGGATCCTGCGGCTGCCCCCGGGCAGCAAGGGGGAGT
CCCCTAAGGAGTGGGGCAAGCTGGAGGACTGGCAGAAGGAGCTCTACAAGCACGTGATGAGGGGCAACTACGAGACGCTGGTCTCCCTGG
ACTACGCCATCTCCAAGCCCGAGGTCCTCTCCCAGATTGAACAAGGGAAGGAGCCCTGCAACTGGCGCCGCCCTGGCCCCAAGATTCCAG
ATGTTCCTGTGGACCCCAGTCCAGGCTCGGGGCCCCCAGTTCCCGCCCCAGACCTCTTGATGCAGATCAAGCAGGAGGGTGAGCTCCAGC
TCCAGGAGCAGCAGGCCCTGGGCGTGGAGGCGTGGGCAGCCGGGCAGCCAGATATTGGGGAGGAGCCCTGGGGCCTCAGCCAGCTGGATT
CCGGAGCAGGAGACATCTCCACGGATGCCACCTCTGGTGTCCATTCCAACTTTTCCACCACCATCCCGCCCACCTCCTGGCAAACGGATC
TCCCTCCCCACCATCCCTCTTCAGCATGCTCGGACGGGACCCTGAAGCTCAACACAGCAGCCTCCACGGAAGATGTAAAAATTGTAATAA
AAACAGAAGTCCAGGAAGAGGAGGTGGTGGCCACACCCGTACATCCTACTGACCTAGAGGCTCACGGGACCCTGTTTGGACCAGGCCAAG
CCACACGGTTCTTCCCTAGTCCTGCCCAGGAAGGAGCCTGGGAAAGCCAGGGCAGCTCCTTCCCCAGCCAGGACCCTGTGCTGGGGCTGC
GAGAGCCCGCCCGGCCTGAGAGGGACATGGGTGAGCTCAGTCCTGCTGTGGCCCAGGAGGAGACCCCTCCTGGGGACTGGCTCTTCGGAG
GGGTCCGGTGGGGCTGGAATTTCCGGTGTAAACCGCCAGTGGGCCTGAACCCGAGGACGGGGCCCGAGGGGCTTCCTTACTCCTCCCCGG
ACAACGGAGAGGCCATCTTGGACCCCAGCCAGGCCCCAAGGCCATTCAACGAACCCTGTAAATACCCTGGCCGGACCAAAGGCTTTGGCC
ACAAGCCAGGGCTGAAGAAGCACCCCGCGGCGCCCCCCGGGGGCCGGCCCTTCACCTGCGCCACGTGTGGGAAGAGCTTCCAGCTGCAAG
TCAGCCTGAGCGCGCACCAGCGCAGCTGTGGGGCGCCCGACGGGTCGGGCCCGGGCACAGGCGGTGGCGGCAGCGGCAGTGGCGGCGGCG
GTGGCGGCAGCGGTGGGGGCAGCGCACGGGATGGCAGCGCCCTTCGGTGTGGGGAGTGCGGCCGTTGCTTCACGCGCCCCGCGCACCTCA
TCCGCCATCGCATGCTGCACACCGGCGAGCGGCCCTTCCCCTGCACCGAGTGTGAGAAGCGCTTCACCGAACGCTCCAAGCTCATCGACC
ACTACCGAACGCACACGGGCGTGCGGCCCTTCACCTGCACCGTCTGCGGCAAAAGCTTCATCCGCAAGGACCACCTCCGCAAGCACCAGC
GCAACCATGCAGCGGGCGCCAAGACCCCGGCCCGAGGCCAGCCACTCCCGACGCCGCCCGCACCTCCTGATCCCTTCAAGAGCCCCGCCT
CCAAAGGACCTTTGGCCTCCACAGACCTTGTGACCGACTGGACTTGTGGCCTCAGCGTCCTGGGACCCACCGATGGCGGGGACATGTGAG
CGCCTCCAGCCCCATAGCCCCTGCCGGCCGCACGTGTAAAAAGCCCCGTGTGCAGGCAGCAGGGCGGCGTGGAAGCTTCAGGCAGACGCG
GGACGGGGAGAACCAAATGTCCAAGTTGCTGAACTGATGATCACTGGAGAAAGAGAAACTATCCACCAGGACAGCTGCCACCTCTAAACC
AAGTAGAATTCTCTGTGAAATGGGAGCGCCGTAGAATTTTAAGTAATTTAATTGCAAACCTGTTTTGTTTTTTGTTTTTTGTTTTTTTTT
AATTCTTGAGGAAAAAGCTGGAAAATAGTAATAGGGCTATTTAAATTTTGTAGGTACTTTTGGTTTTCAGGGCGTGCATTTCTGTCACTA
TCTCACTGAGTCTGATAGTGTGTTGGAAGGTTGGCCAGTTGGGGACCCCTGGCCCACTGACTCCTGGGGATGGGGTCCTGTGTGTGCCCC
TGCTCTGCCCAGTTGGGCTGAGTGGGCCTAGCGCACCAAGCCCCTGGGCAGTGAGGGCCATTGGGTCCCTTGGAGCACACCTCAGTGCAG
CAGGAAGGACCCCTCCGGGAGTAGCGGTTGCATTTCCCAGCTTGCCTCTCCTGAAAAGGCCCCCCAAAAGTGCTGGCCCCAACTTTTCTC
TATTTTGGGCCATCTGTGGTACCCGTCCCAAGGGCACTTGGTGGTGTCCCCTAGTGTGTGACTCCCTGGCCTCATAAGGACGAGTTGTCT
GAAATCCCAGCGTTAGGTCTGGGGAGATGGAGAAGCTGAAACTGGGGAGCTGCACCACAAACGTCTAGCTCTCAGCAGAGCTGGGAGCAA
AGCCTGGCCGCCCACCCCAACCTGGGGCTGCCTCCCACTCCGTGAGATGCTTCTGTCTCCTGTTCACTTTGTGTGGTAGTTTCTTATTTT
CAAAATGCATCTCATTTGATCATTACTGTGACCTTGGGAAGCAGCAGGACAGGGATTTCTTTTTAGAGGTGCAAACTGCTCAGAGGGGAC
ACACCTCAGCCTCTCACTGTGGGTACACGTGGCGTGCCATGAGTGGGGAAGAGCAACAGGCGAGATGCCTCATTCTACTGGAACATCACT
GTGGGTGAACAGAGATTTCCAGGTTTTCCCTCTTAAAATATTTGTCCCACACCGACAAGAGTCCAGTCACCAGGCCTCAAAGGAACTTCT
GCTTGTAGCAGCCGCCTCCCCTGTGCCCCAGCCTCCTTAATGTGTGCACTCTCAGAGGGCACAGCTCGCGAGGCTGGGTTTGGGGGCCAA
GTGGCTTGTTCATTCCAGCATCTAACATCATAAAGGTGGGCCCAGATTTCTTGATTCGACCACAGTGCTGTTCCTACCACACAAATATCC
ATTCCTGTTTTGTTGAAGCAGCCACTGGTCCTCTTGTTTCCCCTGCAGACGGAGGGACCTGGCAGTGCCCATTCATTCAGCCCCCTCATG
CATACTTTTATTAGGCGATAGACTAGTTAAGAAAATTGTTTCTATGTACTGTATATTTTGTACCTGTTTACACTTCTAATATTGATATAA

>28107_28107_4_EZH2-ZNF746_EZH2_chr7_148543561_ENST00000350995_ZNF746_chr7_149191594_ENST00000340622_length(amino acids)=718AA_BP=563
MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEWKQRRIQPVHILTSVSSLRGTREISPWTMAA
TIQAMERKIESQAARLLSLEGRTGMAEKKLADCEKTAVEFGNQLEGKWAVLGTLLQEYGLLQRRLENVENLLRNRNFWILRLPPGSKGES
PKEWGKLEDWQKELYKHVMRGNYETLVSLDYAISKPEVLSQIEQGKEPCNWRRPGPKIPDVPVDPSPGSGPPVPAPDLLMQIKQEGELQL
QEQQALGVEAWAAGQPDIGEEPWGLSQLDSGAGDISTDATSGVHSNFSTTIPPTSWQTDLPPHHPSSACSDGTLKLNTAASTEDVKIVIK
TEVQEEEVVATPVHPTDLEAHGTLFGPGQATRFFPSPAQEGAWESQGSSFPSQDPVLGLREPARPERDMGELSPAVAQEETPPGDWLFGG
VRWGWNFRCKPPVGLNPRTGPEGLPYSSPDNGEAILDPSQAPRPFNEPCKYPGRTKGFGHKPGLKKHPAAPPGGRPFTCATCGKSFQLQV
SLSAHQRSCGAPDGSGPGTGGGGSGSGGGGGGSGGGSARDGSALRCGECGRCFTRPAHLIRHRMLHTGERPFPCTECEKRFTERSKLIDH

--------------------------------------------------------------
>28107_28107_5_EZH2-ZNF746_EZH2_chr7_148543561_ENST00000350995_ZNF746_chr7_149191594_ENST00000458143_length(transcript)=3840nt_BP=338nt
AGAAGGCAGTGGAGCCCCGGCGGCGGCGGCGGCGGCGCGCGGGGGCGACGCGCGGGAACAACGCGAGTCGGCGCGCGGGACGAAGAATAA
TCATGGGCCAGACTGGGAAGAAATCTGAGAAGGGACCAGTTTGTTGGCGGAAGCGTGTAAAATCAGAGTACATGCGACTGAGACAGCTCA
AGAGGTTCAGACGAGCTGATGAAGTAAAGAGTATGTTTAGTTCCAATCGTCAGAAAATTTTGGAAAGAACGGAAATCTTAAACCAAGAAT
GGAAACAGCGAAGGATACAGCCTGTGCACATCCTGACTTCTGTGAGCTCATTGCGCGGGACTAGGGAGATTTCTCCGTGGACGATGGCAG
CCACGATTCAGGCCATGGAGAGGAAGATTGAATCGCAGGCTGCTCGCCTGCTTTCCCTAGAAGGTCGAACCGGGATGGCCGAGAAGAAGC
TGGCTGATTGCGAGAAGACAGCCGTGGAGTTCGGGAACCAGCTGGAGGGCAAGTGGGCCGTGCTGGGGACCCTGCTGCAGGAGTACGGGC
TGCTGCAGAGGCGGCTGGAGAACGTGGAGAACCTGCTGCGCAACAGGAACTTCTGGATCCTGCGGCTGCCCCCGGGCAGCAAGGGGGAGT
CCCCTAAGGAGTGGGGCAAGCTGGAGGACTGGCAGAAGGAGCTCTACAAGCACGTGATGAGGGGCAACTACGAGACGCTGGTCTCCCTGG
ACTACGCCATCTCCAAGCCCGAGGTCCTCTCCCAGATTGAACAAGGGAAGGAGCCCTGCAACTGGCGCCGCCCTGGCCCCAAGATTCCAG
ATGTTCCTGTGGACCCCAGTCCAGGCTCGGGGCCCCCAGTTCCCGCCCCAGACCTCTTGATGCAGATCAAGCAGGAGGGTGAGCTCCAGC
TCCAGGAGCAGCAGGCCCTGGGCGTGGAGGCGTGGGCAGCCGGGCAGCCAGATATTGGGGAGGAGCCCTGGGGCCTCAGCCAGCTGGATT
CCGGAGCAGGAGACATCTCCACGGATGCCACCTCTGGTGTCCATTCCAACTTTTCCACCACCATCCCGCCCACCTCCTGGCAAACGGATC
TCCCTCCCCACCATCCCTCTTCAGCATGCTCGGACGGGACCCTGAAGCTCAACACAGCAGCCTCCACGGAAGCAGATGTAAAAATTGTAA
TAAAAACAGAAGTCCAGGAAGAGGAGGTGGTGGCCACACCCGTACATCCTACTGACCTAGAGGCTCACGGGACCCTGTTTGGACCAGGCC
AAGCCACACGGTTCTTCCCTAGTCCTGCCCAGGAAGGAGCCTGGGAAAGCCAGGGCAGCTCCTTCCCCAGCCAGGACCCTGTGCTGGGGC
TGCGAGAGCCCGCCCGGCCTGAGAGGGACATGGGTGAGCTCAGTCCTGCTGTGGCCCAGGAGGAGACCCCTCCTGGGGACTGGCTCTTCG
GAGGGGTCCGGTGGGGCTGGAATTTCCGGTGTAAACCGCCAGTGGGCCTGAACCCGAGGACGGGGCCCGAGGGGCTTCCTTACTCCTCCC
CGGACAACGGAGAGGCCATCTTGGACCCCAGCCAGGCCCCAAGGCCATTCAACGAACCCTGTAAATACCCTGGCCGGACCAAAGGCTTTG
GCCACAAGCCAGGGCTGAAGAAGCACCCCGCGGCGCCCCCCGGGGGCCGGCCCTTCACCTGCGCCACGTGTGGGAAGAGCTTCCAGCTGC
AAGTCAGCCTGAGCGCGCACCAGCGCAGCTGTGGGGCGCCCGACGGGTCGGGCCCGGGCACAGGCGGTGGCGGCAGCGGCAGTGGCGGCG
GCGGTGGCGGCAGCGGTGGGGGCAGCGCACGGGATGGCAGCGCCCTTCGGTGTGGGGAGTGCGGCCGTTGCTTCACGCGCCCCGCGCACC
TCATCCGCCATCGCATGCTGCACACCGGCGAGCGGCCCTTCCCCTGCACCGAGTGTGAGAAGCGCTTCACCGAACGCTCCAAGCTCATCG
ACCACTACCGAACGCACACGGGCGTGCGGCCCTTCACCTGCACCGTCTGCGGCAAAAGCTTCATCCGCAAGGACCACCTCCGCAAGCACC
AGCGCAACCATGCAGCGGGCGCCAAGACCCCGGCCCGAGGCCAGCCACTCCCGACGCCGCCCGCACCTCCTGATCCCTTCAAGAGCCCCG
CCTCCAAAGGACCTTTGGCCTCCACAGACCTTGTGACCGACTGGACTTGTGGCCTCAGCGTCCTGGGACCCACCGATGGCGGGGACATGT
GAGCGCCTCCAGCCCCATAGCCCCTGCCGGCCGCACGTGTAAAAAGCCCCGTGTGCAGGCAGCAGGGCGGCGTGGAAGCTTCAGGCAGAC
GCGGGACGGGGAGAACCAAATGTCCAAGTTGCTGAACTGATGATCACTGGAGAAAGAGAAACTATCCACCAGGACAGCTGCCACCTCTAA
ACCAAGTAGAATTCTCTGTGAAATGGGAGCGCCGTAGAATTTTAAGTAATTTAATTGCAAACCTGTTTTGTTTTTTGTTTTTTGTTTTTT
TTTAATTCTTGAGGAAAAAGCTGGAAAATAGTAATAGGGCTATTTAAATTTTGTAGGTACTTTTGGTTTTCAGGGCGTGCATTTCTGTCA
CTATCTCACTGAGTCTGATAGTGTGTTGGAAGGTTGGCCAGTTGGGGACCCCTGGCCCACTGACTCCTGGGGATGGGGTCCTGTGTGTGC
CCCTGCTCTGCCCAGTTGGGCTGAGTGGGCCTAGCGCACCAAGCCCCTGGGCAGTGAGGGCCATTGGGTCCCTTGGAGCACACCTCAGTG
CAGCAGGAAGGACCCCTCCGGGAGTAGCGGTTGCATTTCCCAGCTTGCCTCTCCTGAAAAGGCCCCCCAAAAGTGCTGGCCCCAACTTTT
CTCTATTTTGGGCCATCTGTGGTACCCGTCCCAAGGGCACTTGGTGGTGTCCCCTAGTGTGTGACTCCCTGGCCTCATAAGGACGAGTTG
TCTGAAATCCCAGCGTTAGGTCTGGGGAGATGGAGAAGCTGAAACTGGGGAGCTGCACCACAAACGTCTAGCTCTCAGCAGAGCTGGGAG
CAAAGCCTGGCCGCCCACCCCAACCTGGGGCTGCCTCCCACTCCGTGAGATGCTTCTGTCTCCTGTTCACTTTGTGTGGTAGTTTCTTAT
TTTCAAAATGCATCTCATTTGATCATTACTGTGACCTTGGGAAGCAGCAGGACAGGGATTTCTTTTTAGAGGTGCAAACTGCTCAGAGGG
GACACACCTCAGCCTCTCACTGTGGGTACACGTGGCGTGCCATGAGTGGGGAAGAGCAACAGGCGAGATGCCTCATTCTACTGGAACATC
ACTGTGGGTGAACAGAGATTTCCAGGTTTTCCCTCTTAAAATATTTGTCCCACACCGACAAGAGTCCAGTCACCAGGCCTCAAAGGAACT
TCTGCTTGTAGCAGCCGCCTCCCCTGTGCCCCAGCCTCCTTAATGTGTGCACTCTCAGAGGGCACAGCTCGCGAGGCTGGGTTTGGGGGC
CAAGTGGCTTGTTCATTCCAGCATCTAACATCATAAAGGTGGGCCCAGATTTCTTGATTCGACCACAGTGCTGTTCCTACCACACAAATA
TCCATTCCTGTTTTGTTGAAGCAGCCACTGGTCCTCTTGTTTCCCCTGCAGACGGAGGGACCTGGCAGTGCCCATTCATTCAGCCCCCTC
ATGCATACTTTTATTAGGCGATAGACTAGTTAAGAAAATTGTTTCTATGTACTGTATATTTTGTACCTGTTTACACTTCTAATATTGATA

>28107_28107_5_EZH2-ZNF746_EZH2_chr7_148543561_ENST00000350995_ZNF746_chr7_149191594_ENST00000458143_length(amino acids)=719AA_BP=564
MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEWKQRRIQPVHILTSVSSLRGTREISPWTMAA
TIQAMERKIESQAARLLSLEGRTGMAEKKLADCEKTAVEFGNQLEGKWAVLGTLLQEYGLLQRRLENVENLLRNRNFWILRLPPGSKGES
PKEWGKLEDWQKELYKHVMRGNYETLVSLDYAISKPEVLSQIEQGKEPCNWRRPGPKIPDVPVDPSPGSGPPVPAPDLLMQIKQEGELQL
QEQQALGVEAWAAGQPDIGEEPWGLSQLDSGAGDISTDATSGVHSNFSTTIPPTSWQTDLPPHHPSSACSDGTLKLNTAASTEADVKIVI
KTEVQEEEVVATPVHPTDLEAHGTLFGPGQATRFFPSPAQEGAWESQGSSFPSQDPVLGLREPARPERDMGELSPAVAQEETPPGDWLFG
GVRWGWNFRCKPPVGLNPRTGPEGLPYSSPDNGEAILDPSQAPRPFNEPCKYPGRTKGFGHKPGLKKHPAAPPGGRPFTCATCGKSFQLQ
VSLSAHQRSCGAPDGSGPGTGGGGSGSGGGGGGSGGGSARDGSALRCGECGRCFTRPAHLIRHRMLHTGERPFPCTECEKRFTERSKLID

--------------------------------------------------------------
>28107_28107_6_EZH2-ZNF746_EZH2_chr7_148543561_ENST00000350995_ZNF746_chr7_149191594_ENST00000461958_length(transcript)=5168nt_BP=338nt
AGAAGGCAGTGGAGCCCCGGCGGCGGCGGCGGCGGCGCGCGGGGGCGACGCGCGGGAACAACGCGAGTCGGCGCGCGGGACGAAGAATAA
TCATGGGCCAGACTGGGAAGAAATCTGAGAAGGGACCAGTTTGTTGGCGGAAGCGTGTAAAATCAGAGTACATGCGACTGAGACAGCTCA
AGAGGTTCAGACGAGCTGATGAAGTAAAGAGTATGTTTAGTTCCAATCGTCAGAAAATTTTGGAAAGAACGGAAATCTTAAACCAAGAAT
GGAAACAGCGAAGGATACAGCCTGTGCACATCCTGACTTCTGTGAGCTCATTGCGCGGGACTAGGGAGATTTCTCCGTGGACGATGGCAG
CCACGATTCAGGCCATGGAGAGGAAGATTGAATCGCAGGCTGCTCGCCTGCTTTCCCTAGAAGGTCGAACCGGGATGGCCGAGAAGAAGC
TGGCTGATTGCGAGAAGACAGCCGTGGAGTTCGGGAACCAGCTGGAGGGCAAGTGGGCCGTGCTGGGGACCCTGCTGCAGGAGTACGGGC
TGCTGCAGAGGCGGCTGGAGAACGTGGAGAACCTGCTGCGCAACAGGAACTTCTGGATCCTGCGGCTGCCCCCGGGCAGCAAGGGGGAGT
CCCCTAAGGAGTGGGGCAAGCTGGAGGACTGGCAGAAGGAGCTCTACAAGCACGTGATGAGGGGCAACTACGAGACGCTGGTCTCCCTGG
ACTACGCCATCTCCAAGCCCGAGGTCCTCTCCCAGATTGAACAAGGGAAGGAGCCCTGCAACTGGCGCCGCCCTGGCCCCAAGATTCCAG
ATGTTCCTGTGGACCCCAGTCCAGATATCAGCGTCTCAGATTTCCCTGGAGCCAGTCAGCACCTTTGAAAGTTAAGGGAAGGACAGGTGG
ACACAGGAGAAAAACCAAATTCCTAAAGTGAAGACCTGCTGGGTCATTTGACTAGGGAGACCACATCTCTGCAAGGCTCGACCCCTGATT
CCTCCAGAAGACCCGCCCTTGACCGTCCCACCTGCCTTGGTTTTCCCTTTCGTCTGACACTGAGAAAGGTGGTGGTCCGCAGAGGCCCTC
CTGTGCGCCACTTGTGTGAAATTAAATGCATCCCCCATGTTCGTCATCTCATCTCAGTCAGATTTGCACTTTCCTAAGGGCAGAAGCATG
TTCCGGGCTGGCCGCTTTGCCAGTCGTCATCGGGACATTGACAGTTTAGCTCTACAGATGCATTTTTAAGAATCTTCTAGGCGTCAAGGA
CAGTGCTGAACACTAGAGGACAGAAAGATGGCTGAGAACAGATACTATTGGGCTGGAAAAGAGGGTTACAACCCGTGCGCGTCCCCAGCT
TCCTAGCCTGGGTGGGAGGTTCTGGGTGGGTGGGTTTCGTTGTATTTACACCATGTGTGGAGGCTTCCCTCACTTCCACAGCATCATTCA
ATGAGAGTAAAGAGGGGCTGGAAATACGCTGGTTGCTGGTAAGACCCTGTAACACTCTCTAGCTGCACCGTATGATGTTCAGCAGCATCC
GTGGCCTCTACCCACCAGTAGACAAGATGAGTAGACACAAACTCCACTGTCCATCCTGAGCCTGTTGGCAGGGATCTGTGTGGCGTTTAT
CCCTGTCCCCTTTGTCTGAGAAGCCAGGACTCCCAGCTCATCCCTTGCCACATTTGGCCTGACCCATCCCCTTGTGAGACCTCACCTCCC
CTTCTCCTCACCTCCTGCACATCCCTCCACTGAGCCTTGTGGGACTCAGGGCTCAGCAGACCCGCCAGGTCCTGAGTGTTCCCTGCTCGG
ACTGAGCTCCAGGGGACTGCAGCCCTCTGAGTGCTTGTCATCCTCTTCCCTGCCTCTGTCTTGAGCCCAGGCCCACTGGGACAGGGTCCT
CACCCCTCAGATTGTGCCTCTGCCAGCCTCAATCCCTCTCTAGAGACCTTGCCTTTGGGTCCCAGGCCTTGTCTTTTTGCTACTTCTGCA
GACCTTCCCTCTCTTCTCAACACTCTTCCTGCCCTCAGTCTTGGCCATGGCAGCCTCCTTGTTGATTGTCCTGTGCCCCCCCAACCCATC
CCACAGCCATCCGTGACTGTGACGACAGTGACTTTACCATACCCACCATCTCCATCTCCAGCACACCACTCCCTGGCCGCCTCCTGCCGT
CCCTTCAATTCCGTCTGGTGTCCTGATTCCAGCAGTTTTCCAGTCCTTCAAGACCTGCAAGCCATCGACCCTGCTGCCTTTTCACTGCCC
TGACTCATCCTCATTTCCCTCCATGCCCACCATTGTGGTCCCCCCTTACACACACCCTCAGCACTCTTGCCCCTGTTTTGTTCATTGTAT
CCACTTAGTGAAATCCATCGGTGTTCTGCACCTGCAGCCAAGCAGCTGCACGTGGCTGCAGAGAACCAGGTAAGCTGGCTGCTGGTGTCA
CGTGACATTCATGACCAGCGACTTCAGTGGGCGCTCTGCCACACAGTCACACCGTGTCTCCTTAGCCCAGGGGCCAGCAAACTGTGGCTG
AGGGCCAAACCTAGCTCATCTGTTTCTGTATGGTGCACAGCTGAGAACAGTTTTATATTTTAACCCGTTTTTTAAAAGAGAAACGCACCA
CTCACACAGCCCTCTCCACGCCATCTGCCTGCACCAGTGCCCCCTTCTCTGCCTTCACTTCTGTGACTGCTAAACTGTCAACCCTCCAGC
CAAAGCCCCACTTCGATCTGGCACCAGATCCCACCTCATGCCATCTTCTCAAGGGCAATACAAGCAATCCTGCCTTGACCTCTACCCCGG
CAGCCACTGCCCGCTTGTCTGTTCCCCTTTGTGGCAGAGCCCTTGGGGACATCTGCGCTTGCTGTCTCCTGCACCTTCCCCCCCACTCTG
TTACCCCTTCCACCAAAACCTCTCCAACCTCGGTTACCAGGGCCCTCCGTGGTCCTGAATGGTCTGTCTTCTTACTTGGCCTTGTCCCCT
CTACTCTGCCACGTAGGCCCGTCATCTCCTGCCAGCCCCTCTCCTCCTGCCCTGATCCCCCAGTCTTGCCTCAGCCCAGCAGAGTAATCC
CTTTTAGACCCAAGTCCTGGCTTTCCATCTGACCCGCACCGTCAGCTCACCACCTCCACTTTTCTCTCACTCTGCCCAGCTGCAGAGTGC
TGTTCCCTGGTGCTGTTCCCTCCGCCCTGTGCCAGGGCCTTCGCAGTGCCCTCTACTGGGAATCCTCCTCAGGCAGGTCCCACCTGCAGG
CCTTTCGTGTCATCGGCACTGCAGGCCCTCCCCACCCAGGACTCCAGGCCTACTTTCCTGCTTTGGGTCTTCCGTGTTAGACAGTGTCAC
ATAATATATATGTTTCCTATTTATAGATTCATCGTATGTCAGGTCTCCTCCATTAGAATGTCAATTTCAAAAGTATAAAAATTTTTACCT
GTTTAATCATTTTAGGAACCTAGAGTATTGCCTAGTACAGAGTAGGAATTCAATAACTATTTGCTGAATGTATGCTGTTTCAAAATTTAA
AACGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGAAATAATGTATTTCTGATAGCATTTAAATTCCTTTTTAGGTCTCCC
AGGCCTCCCTAGGAATTTTCTGTTTATTCTTTCTATCCACATTTTAAAACGTCTGCTGTGTACTTTGGTAGCTGTAAACAATATATAATA
CGGTTTTTTGTGTTCTGAAAAATTACATAGATGTCATTATATTTATCACTCATTATTCTGTATTTCAGACTTATCCATGTTGATACATGT
AGATCAAGTTCATTCCTTTTAACAGATGCTTAATATTCCAGAAGCAACTATATTGTAACTTATTTTCCATTCCTCCACTGATTGGCACTT
AAGCTTTTTCTGATTGTTCACTCTCACAAGCAATACTGTAGTGAGCGTTCTTGCGCCTGTTTTTTTGTGGCCCTGTGGGGATGCTGCTCC
AGGGAGTAGACCCAGCGGTGGCCTCACCACGTCGTAGGCTTGATTTCATCTCTTCCGTTACTGTATGGCCCTCCCCAGGGGTACCCAGTG
CCAGCGGGTGCTCCTAGAACTTGCTTCCTAACGTCTGCCCAGTTTCCATAATTACATTTTTGCCGACCTGATGGGGGTGAGATGGCCTCT
CGTTTCAACTTGTATTTTCCCCCTTAAGTTGCACGCCCTTTTTATACGATTATTTGGCTGCTTCTCCAGTGAGTTGTCTTCTGTTTTTCT
ATTGAGATATTCTTCATTTTCTTCTTGATTCAGGGCTTCTTTGTATGTGTTCTAGATACAAATCCTTTGTCTATTATTTGTGTTACAAAC
ATTTTCTCCGTGTCGGTGGCAGGTCTTTAACGTTGTAGTTCTTGTATGGAAGTTTTCACTGTTGAAAGAGTCAAACATGTCAGTCTTTTC
CTTTATGATCTGTGCTTTTTCTGTAGTGAGATATCCTTGCTTACCTCACTCAAGGTCAGAAAGATACTCTTCTCTATTTTTTTTATAAAT
TTTTAAAAGTTTTGCTTTTCAAATTTAAGTCTTTAATTTATCTAGAATTAAAATTTGTGTAGCTTGCAAGGGAGGGTTTCAGTTTTTTCT
CCCACAACGATGGTCTCATTTTCCAACAAAGTTTGCTGAATGTGTTAGCTTTTCTCCACTGATTTGTGATGCGATTCTGTCCTGAGCTGG
TTTCTGCATGTGCACAAGTCTGTTTCTGGGTGCTTGCTTCTGTGTCATTGGTCTCTTTGTCAGTCTCTGCACCAACAGCTTGCTCTTTTA
GCTTCATAATAAGCCTTGATATCTAGTAGACTAATCCTTCTCTGCTTGTTCTTCAAAAAACTGTCTTGGCTATTCTTGGATATTTGTTCT
TTTATATGAATTTTGGGATCTGTATGTCAAGTTCCTAAGAAAATCCTGTTGGAAATTTGATTGGAATTGCATTGACTTTACAGTCTAATT
TCTGGAGAATTGCTCTCATGACAACATTAGCCTTTCTACTCATTGGAACACTCATTTATTGAAGGCTTCTATGTGCTTGAATAAGATTTT
ACAGTTTTCTTCTGATAGTTGTTTTTCATTATAAATGGGATTTTTACAGTTTATTAGATGTATTAGTTATTTCAGGTGTACAGGTATGCT

>28107_28107_6_EZH2-ZNF746_EZH2_chr7_148543561_ENST00000350995_ZNF746_chr7_149191594_ENST00000461958_length(amino acids)=261AA_BP=82
MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEWKQRRIQPVHILTSVSSLRGTREISPWTMAA
TIQAMERKIESQAARLLSLEGRTGMAEKKLADCEKTAVEFGNQLEGKWAVLGTLLQEYGLLQRRLENVENLLRNRNFWILRLPPGSKGES

--------------------------------------------------------------
>28107_28107_7_EZH2-ZNF746_EZH2_chr7_148543561_ENST00000460911_ZNF746_chr7_149191594_ENST00000340622_length(transcript)=3836nt_BP=335nt
AGGCAGTGGAGCCCCGGCGGCGGCGGCGGCGGCGCGCGGGGGCGACGCGCGGGAACAACGCGAGTCGGCGCGCGGGACGAAGAATAATCA
TGGGCCAGACTGGGAAGAAATCTGAGAAGGGACCAGTTTGTTGGCGGAAGCGTGTAAAATCAGAGTACATGCGACTGAGACAGCTCAAGA
GGTTCAGACGAGCTGATGAAGTAAAGAGTATGTTTAGTTCCAATCGTCAGAAAATTTTGGAAAGAACGGAAATCTTAAACCAAGAATGGA
AACAGCGAAGGATACAGCCTGTGCACATCCTGACTTCTGTGAGCTCATTGCGCGGGACTAGGGAGATTTCTCCGTGGACGATGGCAGCCA
CGATTCAGGCCATGGAGAGGAAGATTGAATCGCAGGCTGCTCGCCTGCTTTCCCTAGAAGGTCGAACCGGGATGGCCGAGAAGAAGCTGG
CTGATTGCGAGAAGACAGCCGTGGAGTTCGGGAACCAGCTGGAGGGCAAGTGGGCCGTGCTGGGGACCCTGCTGCAGGAGTACGGGCTGC
TGCAGAGGCGGCTGGAGAACGTGGAGAACCTGCTGCGCAACAGGAACTTCTGGATCCTGCGGCTGCCCCCGGGCAGCAAGGGGGAGTCCC
CTAAGGAGTGGGGCAAGCTGGAGGACTGGCAGAAGGAGCTCTACAAGCACGTGATGAGGGGCAACTACGAGACGCTGGTCTCCCTGGACT
ACGCCATCTCCAAGCCCGAGGTCCTCTCCCAGATTGAACAAGGGAAGGAGCCCTGCAACTGGCGCCGCCCTGGCCCCAAGATTCCAGATG
TTCCTGTGGACCCCAGTCCAGGCTCGGGGCCCCCAGTTCCCGCCCCAGACCTCTTGATGCAGATCAAGCAGGAGGGTGAGCTCCAGCTCC
AGGAGCAGCAGGCCCTGGGCGTGGAGGCGTGGGCAGCCGGGCAGCCAGATATTGGGGAGGAGCCCTGGGGCCTCAGCCAGCTGGATTCCG
GAGCAGGAGACATCTCCACGGATGCCACCTCTGGTGTCCATTCCAACTTTTCCACCACCATCCCGCCCACCTCCTGGCAAACGGATCTCC
CTCCCCACCATCCCTCTTCAGCATGCTCGGACGGGACCCTGAAGCTCAACACAGCAGCCTCCACGGAAGATGTAAAAATTGTAATAAAAA
CAGAAGTCCAGGAAGAGGAGGTGGTGGCCACACCCGTACATCCTACTGACCTAGAGGCTCACGGGACCCTGTTTGGACCAGGCCAAGCCA
CACGGTTCTTCCCTAGTCCTGCCCAGGAAGGAGCCTGGGAAAGCCAGGGCAGCTCCTTCCCCAGCCAGGACCCTGTGCTGGGGCTGCGAG
AGCCCGCCCGGCCTGAGAGGGACATGGGTGAGCTCAGTCCTGCTGTGGCCCAGGAGGAGACCCCTCCTGGGGACTGGCTCTTCGGAGGGG
TCCGGTGGGGCTGGAATTTCCGGTGTAAACCGCCAGTGGGCCTGAACCCGAGGACGGGGCCCGAGGGGCTTCCTTACTCCTCCCCGGACA
ACGGAGAGGCCATCTTGGACCCCAGCCAGGCCCCAAGGCCATTCAACGAACCCTGTAAATACCCTGGCCGGACCAAAGGCTTTGGCCACA
AGCCAGGGCTGAAGAAGCACCCCGCGGCGCCCCCCGGGGGCCGGCCCTTCACCTGCGCCACGTGTGGGAAGAGCTTCCAGCTGCAAGTCA
GCCTGAGCGCGCACCAGCGCAGCTGTGGGGCGCCCGACGGGTCGGGCCCGGGCACAGGCGGTGGCGGCAGCGGCAGTGGCGGCGGCGGTG
GCGGCAGCGGTGGGGGCAGCGCACGGGATGGCAGCGCCCTTCGGTGTGGGGAGTGCGGCCGTTGCTTCACGCGCCCCGCGCACCTCATCC
GCCATCGCATGCTGCACACCGGCGAGCGGCCCTTCCCCTGCACCGAGTGTGAGAAGCGCTTCACCGAACGCTCCAAGCTCATCGACCACT
ACCGAACGCACACGGGCGTGCGGCCCTTCACCTGCACCGTCTGCGGCAAAAGCTTCATCCGCAAGGACCACCTCCGCAAGCACCAGCGCA
ACCATGCAGCGGGCGCCAAGACCCCGGCCCGAGGCCAGCCACTCCCGACGCCGCCCGCACCTCCTGATCCCTTCAAGAGCCCCGCCTCCA
AAGGACCTTTGGCCTCCACAGACCTTGTGACCGACTGGACTTGTGGCCTCAGCGTCCTGGGACCCACCGATGGCGGGGACATGTGAGCGC
CTCCAGCCCCATAGCCCCTGCCGGCCGCACGTGTAAAAAGCCCCGTGTGCAGGCAGCAGGGCGGCGTGGAAGCTTCAGGCAGACGCGGGA
CGGGGAGAACCAAATGTCCAAGTTGCTGAACTGATGATCACTGGAGAAAGAGAAACTATCCACCAGGACAGCTGCCACCTCTAAACCAAG
TAGAATTCTCTGTGAAATGGGAGCGCCGTAGAATTTTAAGTAATTTAATTGCAAACCTGTTTTGTTTTTTGTTTTTTGTTTTTTTTTAAT
TCTTGAGGAAAAAGCTGGAAAATAGTAATAGGGCTATTTAAATTTTGTAGGTACTTTTGGTTTTCAGGGCGTGCATTTCTGTCACTATCT
CACTGAGTCTGATAGTGTGTTGGAAGGTTGGCCAGTTGGGGACCCCTGGCCCACTGACTCCTGGGGATGGGGTCCTGTGTGTGCCCCTGC
TCTGCCCAGTTGGGCTGAGTGGGCCTAGCGCACCAAGCCCCTGGGCAGTGAGGGCCATTGGGTCCCTTGGAGCACACCTCAGTGCAGCAG
GAAGGACCCCTCCGGGAGTAGCGGTTGCATTTCCCAGCTTGCCTCTCCTGAAAAGGCCCCCCAAAAGTGCTGGCCCCAACTTTTCTCTAT
TTTGGGCCATCTGTGGTACCCGTCCCAAGGGCACTTGGTGGTGTCCCCTAGTGTGTGACTCCCTGGCCTCATAAGGACGAGTTGTCTGAA
ATCCCAGCGTTAGGTCTGGGGAGATGGAGAAGCTGAAACTGGGGAGCTGCACCACAAACGTCTAGCTCTCAGCAGAGCTGGGAGCAAAGC
CTGGCCGCCCACCCCAACCTGGGGCTGCCTCCCACTCCGTGAGATGCTTCTGTCTCCTGTTCACTTTGTGTGGTAGTTTCTTATTTTCAA
AATGCATCTCATTTGATCATTACTGTGACCTTGGGAAGCAGCAGGACAGGGATTTCTTTTTAGAGGTGCAAACTGCTCAGAGGGGACACA
CCTCAGCCTCTCACTGTGGGTACACGTGGCGTGCCATGAGTGGGGAAGAGCAACAGGCGAGATGCCTCATTCTACTGGAACATCACTGTG
GGTGAACAGAGATTTCCAGGTTTTCCCTCTTAAAATATTTGTCCCACACCGACAAGAGTCCAGTCACCAGGCCTCAAAGGAACTTCTGCT
TGTAGCAGCCGCCTCCCCTGTGCCCCAGCCTCCTTAATGTGTGCACTCTCAGAGGGCACAGCTCGCGAGGCTGGGTTTGGGGGCCAAGTG
GCTTGTTCATTCCAGCATCTAACATCATAAAGGTGGGCCCAGATTTCTTGATTCGACCACAGTGCTGTTCCTACCACACAAATATCCATT
CCTGTTTTGTTGAAGCAGCCACTGGTCCTCTTGTTTCCCCTGCAGACGGAGGGACCTGGCAGTGCCCATTCATTCAGCCCCCTCATGCAT
ACTTTTATTAGGCGATAGACTAGTTAAGAAAATTGTTTCTATGTACTGTATATTTTGTACCTGTTTACACTTCTAATATTGATATAACTG

>28107_28107_7_EZH2-ZNF746_EZH2_chr7_148543561_ENST00000460911_ZNF746_chr7_149191594_ENST00000340622_length(amino acids)=718AA_BP=563
MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEWKQRRIQPVHILTSVSSLRGTREISPWTMAA
TIQAMERKIESQAARLLSLEGRTGMAEKKLADCEKTAVEFGNQLEGKWAVLGTLLQEYGLLQRRLENVENLLRNRNFWILRLPPGSKGES
PKEWGKLEDWQKELYKHVMRGNYETLVSLDYAISKPEVLSQIEQGKEPCNWRRPGPKIPDVPVDPSPGSGPPVPAPDLLMQIKQEGELQL
QEQQALGVEAWAAGQPDIGEEPWGLSQLDSGAGDISTDATSGVHSNFSTTIPPTSWQTDLPPHHPSSACSDGTLKLNTAASTEDVKIVIK
TEVQEEEVVATPVHPTDLEAHGTLFGPGQATRFFPSPAQEGAWESQGSSFPSQDPVLGLREPARPERDMGELSPAVAQEETPPGDWLFGG
VRWGWNFRCKPPVGLNPRTGPEGLPYSSPDNGEAILDPSQAPRPFNEPCKYPGRTKGFGHKPGLKKHPAAPPGGRPFTCATCGKSFQLQV
SLSAHQRSCGAPDGSGPGTGGGGSGSGGGGGGSGGGSARDGSALRCGECGRCFTRPAHLIRHRMLHTGERPFPCTECEKRFTERSKLIDH

--------------------------------------------------------------
>28107_28107_8_EZH2-ZNF746_EZH2_chr7_148543561_ENST00000460911_ZNF746_chr7_149191594_ENST00000458143_length(transcript)=3837nt_BP=335nt
AGGCAGTGGAGCCCCGGCGGCGGCGGCGGCGGCGCGCGGGGGCGACGCGCGGGAACAACGCGAGTCGGCGCGCGGGACGAAGAATAATCA
TGGGCCAGACTGGGAAGAAATCTGAGAAGGGACCAGTTTGTTGGCGGAAGCGTGTAAAATCAGAGTACATGCGACTGAGACAGCTCAAGA
GGTTCAGACGAGCTGATGAAGTAAAGAGTATGTTTAGTTCCAATCGTCAGAAAATTTTGGAAAGAACGGAAATCTTAAACCAAGAATGGA
AACAGCGAAGGATACAGCCTGTGCACATCCTGACTTCTGTGAGCTCATTGCGCGGGACTAGGGAGATTTCTCCGTGGACGATGGCAGCCA
CGATTCAGGCCATGGAGAGGAAGATTGAATCGCAGGCTGCTCGCCTGCTTTCCCTAGAAGGTCGAACCGGGATGGCCGAGAAGAAGCTGG
CTGATTGCGAGAAGACAGCCGTGGAGTTCGGGAACCAGCTGGAGGGCAAGTGGGCCGTGCTGGGGACCCTGCTGCAGGAGTACGGGCTGC
TGCAGAGGCGGCTGGAGAACGTGGAGAACCTGCTGCGCAACAGGAACTTCTGGATCCTGCGGCTGCCCCCGGGCAGCAAGGGGGAGTCCC
CTAAGGAGTGGGGCAAGCTGGAGGACTGGCAGAAGGAGCTCTACAAGCACGTGATGAGGGGCAACTACGAGACGCTGGTCTCCCTGGACT
ACGCCATCTCCAAGCCCGAGGTCCTCTCCCAGATTGAACAAGGGAAGGAGCCCTGCAACTGGCGCCGCCCTGGCCCCAAGATTCCAGATG
TTCCTGTGGACCCCAGTCCAGGCTCGGGGCCCCCAGTTCCCGCCCCAGACCTCTTGATGCAGATCAAGCAGGAGGGTGAGCTCCAGCTCC
AGGAGCAGCAGGCCCTGGGCGTGGAGGCGTGGGCAGCCGGGCAGCCAGATATTGGGGAGGAGCCCTGGGGCCTCAGCCAGCTGGATTCCG
GAGCAGGAGACATCTCCACGGATGCCACCTCTGGTGTCCATTCCAACTTTTCCACCACCATCCCGCCCACCTCCTGGCAAACGGATCTCC
CTCCCCACCATCCCTCTTCAGCATGCTCGGACGGGACCCTGAAGCTCAACACAGCAGCCTCCACGGAAGCAGATGTAAAAATTGTAATAA
AAACAGAAGTCCAGGAAGAGGAGGTGGTGGCCACACCCGTACATCCTACTGACCTAGAGGCTCACGGGACCCTGTTTGGACCAGGCCAAG
CCACACGGTTCTTCCCTAGTCCTGCCCAGGAAGGAGCCTGGGAAAGCCAGGGCAGCTCCTTCCCCAGCCAGGACCCTGTGCTGGGGCTGC
GAGAGCCCGCCCGGCCTGAGAGGGACATGGGTGAGCTCAGTCCTGCTGTGGCCCAGGAGGAGACCCCTCCTGGGGACTGGCTCTTCGGAG
GGGTCCGGTGGGGCTGGAATTTCCGGTGTAAACCGCCAGTGGGCCTGAACCCGAGGACGGGGCCCGAGGGGCTTCCTTACTCCTCCCCGG
ACAACGGAGAGGCCATCTTGGACCCCAGCCAGGCCCCAAGGCCATTCAACGAACCCTGTAAATACCCTGGCCGGACCAAAGGCTTTGGCC
ACAAGCCAGGGCTGAAGAAGCACCCCGCGGCGCCCCCCGGGGGCCGGCCCTTCACCTGCGCCACGTGTGGGAAGAGCTTCCAGCTGCAAG
TCAGCCTGAGCGCGCACCAGCGCAGCTGTGGGGCGCCCGACGGGTCGGGCCCGGGCACAGGCGGTGGCGGCAGCGGCAGTGGCGGCGGCG
GTGGCGGCAGCGGTGGGGGCAGCGCACGGGATGGCAGCGCCCTTCGGTGTGGGGAGTGCGGCCGTTGCTTCACGCGCCCCGCGCACCTCA
TCCGCCATCGCATGCTGCACACCGGCGAGCGGCCCTTCCCCTGCACCGAGTGTGAGAAGCGCTTCACCGAACGCTCCAAGCTCATCGACC
ACTACCGAACGCACACGGGCGTGCGGCCCTTCACCTGCACCGTCTGCGGCAAAAGCTTCATCCGCAAGGACCACCTCCGCAAGCACCAGC
GCAACCATGCAGCGGGCGCCAAGACCCCGGCCCGAGGCCAGCCACTCCCGACGCCGCCCGCACCTCCTGATCCCTTCAAGAGCCCCGCCT
CCAAAGGACCTTTGGCCTCCACAGACCTTGTGACCGACTGGACTTGTGGCCTCAGCGTCCTGGGACCCACCGATGGCGGGGACATGTGAG
CGCCTCCAGCCCCATAGCCCCTGCCGGCCGCACGTGTAAAAAGCCCCGTGTGCAGGCAGCAGGGCGGCGTGGAAGCTTCAGGCAGACGCG
GGACGGGGAGAACCAAATGTCCAAGTTGCTGAACTGATGATCACTGGAGAAAGAGAAACTATCCACCAGGACAGCTGCCACCTCTAAACC
AAGTAGAATTCTCTGTGAAATGGGAGCGCCGTAGAATTTTAAGTAATTTAATTGCAAACCTGTTTTGTTTTTTGTTTTTTGTTTTTTTTT
AATTCTTGAGGAAAAAGCTGGAAAATAGTAATAGGGCTATTTAAATTTTGTAGGTACTTTTGGTTTTCAGGGCGTGCATTTCTGTCACTA
TCTCACTGAGTCTGATAGTGTGTTGGAAGGTTGGCCAGTTGGGGACCCCTGGCCCACTGACTCCTGGGGATGGGGTCCTGTGTGTGCCCC
TGCTCTGCCCAGTTGGGCTGAGTGGGCCTAGCGCACCAAGCCCCTGGGCAGTGAGGGCCATTGGGTCCCTTGGAGCACACCTCAGTGCAG
CAGGAAGGACCCCTCCGGGAGTAGCGGTTGCATTTCCCAGCTTGCCTCTCCTGAAAAGGCCCCCCAAAAGTGCTGGCCCCAACTTTTCTC
TATTTTGGGCCATCTGTGGTACCCGTCCCAAGGGCACTTGGTGGTGTCCCCTAGTGTGTGACTCCCTGGCCTCATAAGGACGAGTTGTCT
GAAATCCCAGCGTTAGGTCTGGGGAGATGGAGAAGCTGAAACTGGGGAGCTGCACCACAAACGTCTAGCTCTCAGCAGAGCTGGGAGCAA
AGCCTGGCCGCCCACCCCAACCTGGGGCTGCCTCCCACTCCGTGAGATGCTTCTGTCTCCTGTTCACTTTGTGTGGTAGTTTCTTATTTT
CAAAATGCATCTCATTTGATCATTACTGTGACCTTGGGAAGCAGCAGGACAGGGATTTCTTTTTAGAGGTGCAAACTGCTCAGAGGGGAC
ACACCTCAGCCTCTCACTGTGGGTACACGTGGCGTGCCATGAGTGGGGAAGAGCAACAGGCGAGATGCCTCATTCTACTGGAACATCACT
GTGGGTGAACAGAGATTTCCAGGTTTTCCCTCTTAAAATATTTGTCCCACACCGACAAGAGTCCAGTCACCAGGCCTCAAAGGAACTTCT
GCTTGTAGCAGCCGCCTCCCCTGTGCCCCAGCCTCCTTAATGTGTGCACTCTCAGAGGGCACAGCTCGCGAGGCTGGGTTTGGGGGCCAA
GTGGCTTGTTCATTCCAGCATCTAACATCATAAAGGTGGGCCCAGATTTCTTGATTCGACCACAGTGCTGTTCCTACCACACAAATATCC
ATTCCTGTTTTGTTGAAGCAGCCACTGGTCCTCTTGTTTCCCCTGCAGACGGAGGGACCTGGCAGTGCCCATTCATTCAGCCCCCTCATG
CATACTTTTATTAGGCGATAGACTAGTTAAGAAAATTGTTTCTATGTACTGTATATTTTGTACCTGTTTACACTTCTAATATTGATATAA

>28107_28107_8_EZH2-ZNF746_EZH2_chr7_148543561_ENST00000460911_ZNF746_chr7_149191594_ENST00000458143_length(amino acids)=719AA_BP=564
MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEWKQRRIQPVHILTSVSSLRGTREISPWTMAA
TIQAMERKIESQAARLLSLEGRTGMAEKKLADCEKTAVEFGNQLEGKWAVLGTLLQEYGLLQRRLENVENLLRNRNFWILRLPPGSKGES
PKEWGKLEDWQKELYKHVMRGNYETLVSLDYAISKPEVLSQIEQGKEPCNWRRPGPKIPDVPVDPSPGSGPPVPAPDLLMQIKQEGELQL
QEQQALGVEAWAAGQPDIGEEPWGLSQLDSGAGDISTDATSGVHSNFSTTIPPTSWQTDLPPHHPSSACSDGTLKLNTAASTEADVKIVI
KTEVQEEEVVATPVHPTDLEAHGTLFGPGQATRFFPSPAQEGAWESQGSSFPSQDPVLGLREPARPERDMGELSPAVAQEETPPGDWLFG
GVRWGWNFRCKPPVGLNPRTGPEGLPYSSPDNGEAILDPSQAPRPFNEPCKYPGRTKGFGHKPGLKKHPAAPPGGRPFTCATCGKSFQLQ
VSLSAHQRSCGAPDGSGPGTGGGGSGSGGGGGGSGGGSARDGSALRCGECGRCFTRPAHLIRHRMLHTGERPFPCTECEKRFTERSKLID

--------------------------------------------------------------
>28107_28107_9_EZH2-ZNF746_EZH2_chr7_148543561_ENST00000460911_ZNF746_chr7_149191594_ENST00000461958_length(transcript)=5165nt_BP=335nt
AGGCAGTGGAGCCCCGGCGGCGGCGGCGGCGGCGCGCGGGGGCGACGCGCGGGAACAACGCGAGTCGGCGCGCGGGACGAAGAATAATCA
TGGGCCAGACTGGGAAGAAATCTGAGAAGGGACCAGTTTGTTGGCGGAAGCGTGTAAAATCAGAGTACATGCGACTGAGACAGCTCAAGA
GGTTCAGACGAGCTGATGAAGTAAAGAGTATGTTTAGTTCCAATCGTCAGAAAATTTTGGAAAGAACGGAAATCTTAAACCAAGAATGGA
AACAGCGAAGGATACAGCCTGTGCACATCCTGACTTCTGTGAGCTCATTGCGCGGGACTAGGGAGATTTCTCCGTGGACGATGGCAGCCA
CGATTCAGGCCATGGAGAGGAAGATTGAATCGCAGGCTGCTCGCCTGCTTTCCCTAGAAGGTCGAACCGGGATGGCCGAGAAGAAGCTGG
CTGATTGCGAGAAGACAGCCGTGGAGTTCGGGAACCAGCTGGAGGGCAAGTGGGCCGTGCTGGGGACCCTGCTGCAGGAGTACGGGCTGC
TGCAGAGGCGGCTGGAGAACGTGGAGAACCTGCTGCGCAACAGGAACTTCTGGATCCTGCGGCTGCCCCCGGGCAGCAAGGGGGAGTCCC
CTAAGGAGTGGGGCAAGCTGGAGGACTGGCAGAAGGAGCTCTACAAGCACGTGATGAGGGGCAACTACGAGACGCTGGTCTCCCTGGACT
ACGCCATCTCCAAGCCCGAGGTCCTCTCCCAGATTGAACAAGGGAAGGAGCCCTGCAACTGGCGCCGCCCTGGCCCCAAGATTCCAGATG
TTCCTGTGGACCCCAGTCCAGATATCAGCGTCTCAGATTTCCCTGGAGCCAGTCAGCACCTTTGAAAGTTAAGGGAAGGACAGGTGGACA
CAGGAGAAAAACCAAATTCCTAAAGTGAAGACCTGCTGGGTCATTTGACTAGGGAGACCACATCTCTGCAAGGCTCGACCCCTGATTCCT
CCAGAAGACCCGCCCTTGACCGTCCCACCTGCCTTGGTTTTCCCTTTCGTCTGACACTGAGAAAGGTGGTGGTCCGCAGAGGCCCTCCTG
TGCGCCACTTGTGTGAAATTAAATGCATCCCCCATGTTCGTCATCTCATCTCAGTCAGATTTGCACTTTCCTAAGGGCAGAAGCATGTTC
CGGGCTGGCCGCTTTGCCAGTCGTCATCGGGACATTGACAGTTTAGCTCTACAGATGCATTTTTAAGAATCTTCTAGGCGTCAAGGACAG
TGCTGAACACTAGAGGACAGAAAGATGGCTGAGAACAGATACTATTGGGCTGGAAAAGAGGGTTACAACCCGTGCGCGTCCCCAGCTTCC
TAGCCTGGGTGGGAGGTTCTGGGTGGGTGGGTTTCGTTGTATTTACACCATGTGTGGAGGCTTCCCTCACTTCCACAGCATCATTCAATG
AGAGTAAAGAGGGGCTGGAAATACGCTGGTTGCTGGTAAGACCCTGTAACACTCTCTAGCTGCACCGTATGATGTTCAGCAGCATCCGTG
GCCTCTACCCACCAGTAGACAAGATGAGTAGACACAAACTCCACTGTCCATCCTGAGCCTGTTGGCAGGGATCTGTGTGGCGTTTATCCC
TGTCCCCTTTGTCTGAGAAGCCAGGACTCCCAGCTCATCCCTTGCCACATTTGGCCTGACCCATCCCCTTGTGAGACCTCACCTCCCCTT
CTCCTCACCTCCTGCACATCCCTCCACTGAGCCTTGTGGGACTCAGGGCTCAGCAGACCCGCCAGGTCCTGAGTGTTCCCTGCTCGGACT
GAGCTCCAGGGGACTGCAGCCCTCTGAGTGCTTGTCATCCTCTTCCCTGCCTCTGTCTTGAGCCCAGGCCCACTGGGACAGGGTCCTCAC
CCCTCAGATTGTGCCTCTGCCAGCCTCAATCCCTCTCTAGAGACCTTGCCTTTGGGTCCCAGGCCTTGTCTTTTTGCTACTTCTGCAGAC
CTTCCCTCTCTTCTCAACACTCTTCCTGCCCTCAGTCTTGGCCATGGCAGCCTCCTTGTTGATTGTCCTGTGCCCCCCCAACCCATCCCA
CAGCCATCCGTGACTGTGACGACAGTGACTTTACCATACCCACCATCTCCATCTCCAGCACACCACTCCCTGGCCGCCTCCTGCCGTCCC
TTCAATTCCGTCTGGTGTCCTGATTCCAGCAGTTTTCCAGTCCTTCAAGACCTGCAAGCCATCGACCCTGCTGCCTTTTCACTGCCCTGA
CTCATCCTCATTTCCCTCCATGCCCACCATTGTGGTCCCCCCTTACACACACCCTCAGCACTCTTGCCCCTGTTTTGTTCATTGTATCCA
CTTAGTGAAATCCATCGGTGTTCTGCACCTGCAGCCAAGCAGCTGCACGTGGCTGCAGAGAACCAGGTAAGCTGGCTGCTGGTGTCACGT
GACATTCATGACCAGCGACTTCAGTGGGCGCTCTGCCACACAGTCACACCGTGTCTCCTTAGCCCAGGGGCCAGCAAACTGTGGCTGAGG
GCCAAACCTAGCTCATCTGTTTCTGTATGGTGCACAGCTGAGAACAGTTTTATATTTTAACCCGTTTTTTAAAAGAGAAACGCACCACTC
ACACAGCCCTCTCCACGCCATCTGCCTGCACCAGTGCCCCCTTCTCTGCCTTCACTTCTGTGACTGCTAAACTGTCAACCCTCCAGCCAA
AGCCCCACTTCGATCTGGCACCAGATCCCACCTCATGCCATCTTCTCAAGGGCAATACAAGCAATCCTGCCTTGACCTCTACCCCGGCAG
CCACTGCCCGCTTGTCTGTTCCCCTTTGTGGCAGAGCCCTTGGGGACATCTGCGCTTGCTGTCTCCTGCACCTTCCCCCCCACTCTGTTA
CCCCTTCCACCAAAACCTCTCCAACCTCGGTTACCAGGGCCCTCCGTGGTCCTGAATGGTCTGTCTTCTTACTTGGCCTTGTCCCCTCTA
CTCTGCCACGTAGGCCCGTCATCTCCTGCCAGCCCCTCTCCTCCTGCCCTGATCCCCCAGTCTTGCCTCAGCCCAGCAGAGTAATCCCTT
TTAGACCCAAGTCCTGGCTTTCCATCTGACCCGCACCGTCAGCTCACCACCTCCACTTTTCTCTCACTCTGCCCAGCTGCAGAGTGCTGT
TCCCTGGTGCTGTTCCCTCCGCCCTGTGCCAGGGCCTTCGCAGTGCCCTCTACTGGGAATCCTCCTCAGGCAGGTCCCACCTGCAGGCCT
TTCGTGTCATCGGCACTGCAGGCCCTCCCCACCCAGGACTCCAGGCCTACTTTCCTGCTTTGGGTCTTCCGTGTTAGACAGTGTCACATA
ATATATATGTTTCCTATTTATAGATTCATCGTATGTCAGGTCTCCTCCATTAGAATGTCAATTTCAAAAGTATAAAAATTTTTACCTGTT
TAATCATTTTAGGAACCTAGAGTATTGCCTAGTACAGAGTAGGAATTCAATAACTATTTGCTGAATGTATGCTGTTTCAAAATTTAAAAC
GTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGAAATAATGTATTTCTGATAGCATTTAAATTCCTTTTTAGGTCTCCCAGG
CCTCCCTAGGAATTTTCTGTTTATTCTTTCTATCCACATTTTAAAACGTCTGCTGTGTACTTTGGTAGCTGTAAACAATATATAATACGG
TTTTTTGTGTTCTGAAAAATTACATAGATGTCATTATATTTATCACTCATTATTCTGTATTTCAGACTTATCCATGTTGATACATGTAGA
TCAAGTTCATTCCTTTTAACAGATGCTTAATATTCCAGAAGCAACTATATTGTAACTTATTTTCCATTCCTCCACTGATTGGCACTTAAG
CTTTTTCTGATTGTTCACTCTCACAAGCAATACTGTAGTGAGCGTTCTTGCGCCTGTTTTTTTGTGGCCCTGTGGGGATGCTGCTCCAGG
GAGTAGACCCAGCGGTGGCCTCACCACGTCGTAGGCTTGATTTCATCTCTTCCGTTACTGTATGGCCCTCCCCAGGGGTACCCAGTGCCA
GCGGGTGCTCCTAGAACTTGCTTCCTAACGTCTGCCCAGTTTCCATAATTACATTTTTGCCGACCTGATGGGGGTGAGATGGCCTCTCGT
TTCAACTTGTATTTTCCCCCTTAAGTTGCACGCCCTTTTTATACGATTATTTGGCTGCTTCTCCAGTGAGTTGTCTTCTGTTTTTCTATT
GAGATATTCTTCATTTTCTTCTTGATTCAGGGCTTCTTTGTATGTGTTCTAGATACAAATCCTTTGTCTATTATTTGTGTTACAAACATT
TTCTCCGTGTCGGTGGCAGGTCTTTAACGTTGTAGTTCTTGTATGGAAGTTTTCACTGTTGAAAGAGTCAAACATGTCAGTCTTTTCCTT
TATGATCTGTGCTTTTTCTGTAGTGAGATATCCTTGCTTACCTCACTCAAGGTCAGAAAGATACTCTTCTCTATTTTTTTTATAAATTTT
TAAAAGTTTTGCTTTTCAAATTTAAGTCTTTAATTTATCTAGAATTAAAATTTGTGTAGCTTGCAAGGGAGGGTTTCAGTTTTTTCTCCC
ACAACGATGGTCTCATTTTCCAACAAAGTTTGCTGAATGTGTTAGCTTTTCTCCACTGATTTGTGATGCGATTCTGTCCTGAGCTGGTTT
CTGCATGTGCACAAGTCTGTTTCTGGGTGCTTGCTTCTGTGTCATTGGTCTCTTTGTCAGTCTCTGCACCAACAGCTTGCTCTTTTAGCT
TCATAATAAGCCTTGATATCTAGTAGACTAATCCTTCTCTGCTTGTTCTTCAAAAAACTGTCTTGGCTATTCTTGGATATTTGTTCTTTT
ATATGAATTTTGGGATCTGTATGTCAAGTTCCTAAGAAAATCCTGTTGGAAATTTGATTGGAATTGCATTGACTTTACAGTCTAATTTCT
GGAGAATTGCTCTCATGACAACATTAGCCTTTCTACTCATTGGAACACTCATTTATTGAAGGCTTCTATGTGCTTGAATAAGATTTTACA
GTTTTCTTCTGATAGTTGTTTTTCATTATAAATGGGATTTTTACAGTTTATTAGATGTATTAGTTATTTCAGGTGTACAGGTATGCTGTT

>28107_28107_9_EZH2-ZNF746_EZH2_chr7_148543561_ENST00000460911_ZNF746_chr7_149191594_ENST00000461958_length(amino acids)=261AA_BP=82
MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEWKQRRIQPVHILTSVSSLRGTREISPWTMAA
TIQAMERKIESQAARLLSLEGRTGMAEKKLADCEKTAVEFGNQLEGKWAVLGTLLQEYGLLQRRLENVENLLRNRNFWILRLPPGSKGES

--------------------------------------------------------------

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Fusion Gene PPI Analysis for EZH2-ZNF746


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneEZH2chr7:148543561chr7:149191594ENST00000320356-32039_6882.0752.0EED
HgeneEZH2chr7:148543561chr7:149191594ENST00000350995-31939_6882.0708.0EED
HgeneEZH2chr7:148543561chr7:149191594ENST00000460911-32039_6882.0747.0EED


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneEZH2chr7:148543561chr7:149191594ENST00000320356-320329_52282.0752.0CDYL
HgeneEZH2chr7:148543561chr7:149191594ENST00000350995-319329_52282.0708.0CDYL
HgeneEZH2chr7:148543561chr7:149191594ENST00000460911-320329_52282.0747.0CDYL
HgeneEZH2chr7:148543561chr7:149191594ENST00000476773-119329_5220696.0CDYL
HgeneEZH2chr7:148543561chr7:149191594ENST00000478654-120329_5220696.0CDYL
HgeneEZH2chr7:148543561chr7:149191594ENST00000483967-120329_5220738.0CDYL
HgeneEZH2chr7:148543561chr7:149191594ENST00000541220-119329_5220696.0CDYL
HgeneEZH2chr7:148543561chr7:149191594ENST00000320356-3201_34082.0752.0DNMT1%2C DNMT3A and DNMT3B
HgeneEZH2chr7:148543561chr7:149191594ENST00000350995-3191_34082.0708.0DNMT1%2C DNMT3A and DNMT3B
HgeneEZH2chr7:148543561chr7:149191594ENST00000460911-3201_34082.0747.0DNMT1%2C DNMT3A and DNMT3B
HgeneEZH2chr7:148543561chr7:149191594ENST00000476773-1191_3400696.0DNMT1%2C DNMT3A and DNMT3B
HgeneEZH2chr7:148543561chr7:149191594ENST00000478654-1201_3400696.0DNMT1%2C DNMT3A and DNMT3B
HgeneEZH2chr7:148543561chr7:149191594ENST00000483967-1201_3400738.0DNMT1%2C DNMT3A and DNMT3B
HgeneEZH2chr7:148543561chr7:149191594ENST00000541220-1191_3400696.0DNMT1%2C DNMT3A and DNMT3B
HgeneEZH2chr7:148543561chr7:149191594ENST00000476773-11939_680696.0EED
HgeneEZH2chr7:148543561chr7:149191594ENST00000478654-12039_680696.0EED
HgeneEZH2chr7:148543561chr7:149191594ENST00000483967-12039_680738.0EED
HgeneEZH2chr7:148543561chr7:149191594ENST00000541220-11939_680696.0EED


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for EZH2-ZNF746


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for EZH2-ZNF746


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource