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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:EZR-IGF2R (FusionGDB2 ID:28118)

Fusion Gene Summary for EZR-IGF2R

check button Fusion gene summary
Fusion gene informationFusion gene name: EZR-IGF2R
Fusion gene ID: 28118
HgeneTgene
Gene symbol

EZR

IGF2R

Gene ID

7430

3482

Gene nameezrininsulin like growth factor 2 receptor
SynonymsCVIL|CVL|HEL-S-105|VIL2CD222|CI-M6PR|CIMPR|M6P-R|M6P/IGF2R|MPR 300|MPR1|MPR300|MPRI
Cytomap

6q25.3

6q25.3

Type of geneprotein-codingprotein-coding
Descriptionezrincytovillin 2epididymis secretory protein Li 105p81villin 2 (ezrin)cation-independent mannose-6-phosphate receptor300 kDa mannose 6-phosphate receptorCI Man-6-P receptorIGF-II receptorM6P/IGF2 receptorinsulin-like growth factor II receptor
Modification date2020032220200315
UniProtAcc

P15311

P11717

Ensembl transtripts involved in fusion geneENST00000337147, ENST00000367075, 
ENST00000392177, ENST00000476189, 
ENST00000475584, ENST00000356956, 
Fusion gene scores* DoF score26 X 22 X 10=57203 X 3 X 3=27
# samples 323
** MAII scorelog2(32/5720*10)=-4.15987133677839
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: EZR [Title/Abstract] AND IGF2R [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointEZR(159239114)-IGF2R(160445604), # samples:1
Anticipated loss of major functional domain due to fusion event.EZR-IGF2R seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
EZR-IGF2R seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
EZR-IGF2R seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneEZR

GO:0048015

phosphatidylinositol-mediated signaling

25591774

HgeneEZR

GO:0051017

actin filament bundle assembly

10793131


check buttonFusion gene breakpoints across EZR (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across IGF2R (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A8-A08L-01AEZRchr6

159239114

-IGF2Rchr6

160445604

+


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Fusion Gene ORF analysis for EZR-IGF2R

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000337147ENST00000475584EZRchr6

159239114

-IGF2Rchr6

160445604

+
5CDS-intronENST00000367075ENST00000475584EZRchr6

159239114

-IGF2Rchr6

160445604

+
5CDS-intronENST00000392177ENST00000475584EZRchr6

159239114

-IGF2Rchr6

160445604

+
5UTR-3CDSENST00000476189ENST00000356956EZRchr6

159239114

-IGF2Rchr6

160445604

+
5UTR-intronENST00000476189ENST00000475584EZRchr6

159239114

-IGF2Rchr6

160445604

+
Frame-shiftENST00000367075ENST00000356956EZRchr6

159239114

-IGF2Rchr6

160445604

+
In-frameENST00000337147ENST00000356956EZRchr6

159239114

-IGF2Rchr6

160445604

+
In-frameENST00000392177ENST00000356956EZRchr6

159239114

-IGF2Rchr6

160445604

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000337147EZRchr6159239114-ENST00000356956IGF2Rchr6160445604+85761466271082348
ENST00000392177EZRchr6159239114-ENST00000356956IGF2Rchr6160445604+85821526871142348

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000337147ENST00000356956EZRchr6159239114-IGF2Rchr6160445604+0.0002686270.99973136
ENST00000392177ENST00000356956EZRchr6159239114-IGF2Rchr6160445604+0.0002660680.99973387

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Fusion Genomic Features for EZR-IGF2R


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
EZRchr6159239113-IGF2Rchr6160445603+2.78E-050.9999721
EZRchr6159239113-IGF2Rchr6160445603+2.78E-050.9999721

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for EZR-IGF2R


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:159239114/chr6:160445604)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EZR

P15311

IGF2R

P11717

FUNCTION: Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis. {ECO:0000269|PubMed:17881735, ECO:0000269|PubMed:18270268, ECO:0000269|PubMed:19111582}.FUNCTION: Mediates the transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes (PubMed:2963003, PubMed:18817523). Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex (PubMed:2963003, PubMed:18817523). The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer (PubMed:18817523). This receptor also binds IGF2 (PubMed:18046459). Acts as a positive regulator of T-cell coactivation by binding DPP4 (PubMed:10900005). {ECO:0000269|PubMed:10900005, ECO:0000269|PubMed:18046459, ECO:0000269|PubMed:18817523, ECO:0000269|PubMed:2963003}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneIGF2Rchr6:159239114chr6:160445604ENST000003569563481082_12191712492.0DomainMRH 8
TgeneIGF2Rchr6:159239114chr6:160445604ENST000003569563481225_13631712492.0DomainMRH 9
TgeneIGF2Rchr6:159239114chr6:160445604ENST000003569563481367_15081712492.0DomainMRH 10
TgeneIGF2Rchr6:159239114chr6:160445604ENST000003569563481514_16481712492.0DomainMRH 11
TgeneIGF2Rchr6:159239114chr6:160445604ENST000003569563481650_17971712492.0DomainMRH 12
TgeneIGF2Rchr6:159239114chr6:160445604ENST00000356956348172_3201712492.0DomainMRH 2
TgeneIGF2Rchr6:159239114chr6:160445604ENST000003569563481802_19891712492.0DomainFibronectin type-II
TgeneIGF2Rchr6:159239114chr6:160445604ENST000003569563481992_21271712492.0DomainMRH 14
TgeneIGF2Rchr6:159239114chr6:160445604ENST000003569563482135_22801712492.0DomainMRH 15
TgeneIGF2Rchr6:159239114chr6:160445604ENST00000356956348326_4681712492.0DomainMRH 3
TgeneIGF2Rchr6:159239114chr6:160445604ENST00000356956348473_6191712492.0DomainMRH 4
TgeneIGF2Rchr6:159239114chr6:160445604ENST00000356956348625_7621712492.0DomainMRH 5
TgeneIGF2Rchr6:159239114chr6:160445604ENST00000356956348765_9241712492.0DomainMRH 6
TgeneIGF2Rchr6:159239114chr6:160445604ENST00000356956348932_10791712492.0DomainMRH 7
TgeneIGF2Rchr6:159239114chr6:160445604ENST000003569563482328_24911712492.0Topological domainCytoplasmic
TgeneIGF2Rchr6:159239114chr6:160445604ENST000003569563482305_23271712492.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEZRchr6:159239114chr6:160445604ENST00000337147-1132_2954587.0DomainFERM
HgeneEZRchr6:159239114chr6:160445604ENST00000367075-2142_2954587.0DomainFERM
HgeneEZRchr6:159239114chr6:160445604ENST00000337147-113115_1204587.0Motif[IL]-x-C-x-x-[DE] motif
HgeneEZRchr6:159239114chr6:160445604ENST00000367075-214115_1204587.0Motif[IL]-x-C-x-x-[DE] motif
TgeneIGF2Rchr6:159239114chr6:160445604ENST0000035695634847_1631712492.0DomainMRH 1
TgeneIGF2Rchr6:159239114chr6:160445604ENST0000035695634841_23041712492.0Topological domainLumenal


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Fusion Gene Sequence for EZR-IGF2R


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>28118_28118_1_EZR-IGF2R_EZR_chr6_159239114_ENST00000337147_IGF2R_chr6_160445604_ENST00000356956_length(transcript)=8576nt_BP=146nt
GGCGCGGCAGGAGGACGAGGCAGGGCGGGCGGGCGCTCTAAGGGTTCTGCTCTGACTCCAGGTTGGGACAGCGTCTTCGCTGCTGCTGGA
TAGTCGTGTTTTCGGGGATCGAGGATACTCACCAGAAACCGAAAATGCCGAAACCAGTGCCATGCTATGTGTTTGATGAAGAGTTGAGGA
AGCATGATCTCAATCCTCTGATCAAGCTTAGTGGTGCCTACTTGGTGGATGACTCCGATCCGGACACTTCTCTATTCATCAATGTTTGTA
GAGACATAGACACACTACGAGACCCAGGTTCACAGCTGCGGGCCTGTCCCCCCGGCACTGCCGCCTGCCTGGTAAGAGGACACCAGGCGT
TTGATGTTGGCCAGCCCCGGGACGGACTGAAGCTGGTGCGCAAGGACAGGCTTGTCCTGAGTTACGTGAGGGAAGAGGCAGGAAAGCTAG
ACTTTTGTGATGGTCACAGCCCTGCGGTGACTATTACATTTGTTTGCCCGTCGGAGCGGAGAGAGGGCACCATTCCCAAACTCACAGCTA
AATCCAACTGCCGCTATGAAATTGAGTGGATTACTGAGTATGCCTGCCACAGAGATTACCTGGAAAGTAAAACTTGTTCTCTGAGCGGCG
AGCAGCAGGATGTCTCCATAGACCTCACACCACTTGCCCAGAGCGGAGGTTCATCCTATATTTCAGATGGAAAAGAATATTTGTTTTATT
TGAATGTCTGTGGAGAAACTGAAATACAGTTCTGTAATAAAAAACAAGCTGCAGTTTGCCAAGTGAAAAAGAGCGATACCTCTCAAGTCA
AAGCAGCAGGAAGATACCACAATCAGACCCTCCGATATTCGGATGGAGACCTCACCTTGATATATTTTGGAGGTGATGAATGCAGCTCAG
GGTTTCAGCGGATGAGCGTCATAAACTTTGAGTGCAATAAAACCGCAGGTAACGATGGGAAAGGAACTCCTGTATTCACAGGGGAGGTTG
ACTGCACCTACTTCTTCACATGGGACACGGAATACGCCTGTGTTAAGGAGAAGGAAGACCTCCTCTGCGGTGCCACCGACGGGAAGAAGC
GCTATGACCTGTCCGCGCTGGTCCGCCATGCAGAACCAGAGCAGAATTGGGAAGCTGTGGATGGCAGTCAGACGGAAACAGAGAAGAAGC
ATTTTTTCATTAATATTTGTCACAGAGTGCTGCAGGAAGGCAAGGCACGAGGGTGTCCCGAGGACGCGGCAGTGTGTGCAGTGGATAAAA
ATGGAAGTAAAAATCTGGGAAAATTTATTTCCTCTCCCATGAAAGAGAAAGGAAACATTCAACTCTCTTATTCAGATGGTGATGATTGTG
GTCATGGCAAGAAAATTAAAACTAATATCACACTTGTATGCAAGCCAGGTGATCTGGAAAGTGCACCAGTGTTGAGAACTTCTGGGGAAG
GCGGTTGCTTTTATGAGTTTGAGTGGCACACAGCTGCGGCCTGTGTGCTGTCTAAGACAGAAGGGGAGAACTGCACGGTCTTTGACTCCC
AGGCAGGGTTTTCTTTTGACTTATCACCTCTCACAAAGAAAAATGGTGCCTATAAAGTTGAGACAAAGAAGTATGACTTTTATATAAATG
TGTGTGGCCCGGTGTCTGTGAGCCCCTGTCAGCCAGACTCAGGAGCCTGCCAGGTGGCAAAAAGTGATGAGAAGACTTGGAACTTGGGTC
TGAGTAATGCGAAGCTTTCATATTATGATGGGATGATCCAACTGAACTACAGAGGCGGCACACCCTATAACAATGAAAGACACACACCGA
GAGCTACGCTCATCACCTTTCTCTGTGATCGAGACGCGGGAGTGGGCTTCCCTGAATATCAGGAAGAGGATAACTCCACCTACAACTTCC
GGTGGTACACCAGCTATGCCTGCCCGGAGGAGCCCCTGGAATGCGTAGTGACCGACCCCTCCACGCTGGAGCAGTACGACCTCTCCAGTC
TGGCAAAATCTGAAGGTGGCCTTGGAGGAAACTGGTATGCCATGGACAACTCAGGGGAACATGTCACGTGGAGGAAATACTACATTAACG
TGTGTCGGCCTCTGAATCCAGTGCCGGGCTGCAACCGATATGCATCGGCTTGCCAGATGAAGTATGAAAAAGATCAGGGCTCCTTCACTG
AAGTGGTTTCCATCAGTAACTTGGGAATGGCAAAGACCGGCCCGGTGGTTGAGGACAGCGGCAGCCTCCTTCTGGAATACGTGAATGGGT
CGGCCTGCACCACCAGCGATGGCAGACAGACCACATATACCACGAGGATCCATCTCGTCTGCTCCAGGGGCAGGCTGAACAGCCACCCCA
TCTTTTCTCTCAACTGGGAGTGTGTGGTCAGTTTCCTGTGGAACACAGAGGCTGCCTGTCCCATTCAGACAACGACGGATACAGACCAGG
CTTGCTCTATAAGGGATCCCAACAGTGGATTTGTGTTTAATCTTAATCCGCTAAACAGTTCGCAAGGATATAACGTCTCTGGCATTGGGA
AGATTTTTATGTTTAATGTCTGCGGCACAATGCCTGTCTGTGGGACCATCCTGGGAAAACCTGCTTCTGGCTGTGAGGCAGAAACCCAAA
CTGAAGAGCTCAAGAATTGGAAGCCAGCAAGGCCAGTCGGAATTGAGAAAAGCCTCCAGCTGTCCACAGAGGGCTTCATCACTCTGACCT
ACAAAGGGCCTCTCTCTGCCAAAGGTACCGCTGATGCTTTTATCGTCCGCTTTGTTTGCAATGATGATGTTTACTCAGGGCCCCTCAAAT
TCCTGCATCAAGATATCGACTCTGGGCAAGGGATCCGAAACACTTACTTTGAGTTTGAAACCGCGTTGGCCTGTGTTCCTTCTCCAGTGG
ACTGCCAAGTCACCGACCTGGCTGGAAATGAGTACGACCTGACTGGCCTAAGCACAGTCAGGAAACCTTGGACGGCTGTTGACACCTCTG
TCGATGGGAGAAAGAGGACTTTCTATTTGAGCGTTTGCAATCCTCTCCCTTACATTCCTGGATGCCAGGGCAGCGCAGTGGGGTCTTGCT
TAGTGTCAGAAGGCAATAGCTGGAATCTGGGTGTGGTGCAGATGAGTCCCCAAGCCGCGGCGAATGGATCTTTGAGCATCATGTATGTCA
ACGGTGACAAGTGTGGGAACCAGCGCTTCTCCACCAGGATCACGTTTGAGTGTGCTCAGATATCGGGCTCACCAGCATTTCAGCTTCAGG
ATGGTTGTGAGTACGTGTTTATCTGGAGAACTGTGGAAGCCTGTCCCGTTGTCAGAGTGGAAGGGGACAACTGTGAGGTGAAAGACCCAA
GGCATGGCAACTTGTATGACCTGAAGCCCCTGGGCCTCAACGACACCATCGTGAGCGCTGGCGAATACACTTATTACTTCCGGGTCTGTG
GGAAGCTTTCCTCAGACGTCTGCCCCACAAGTGACAAGTCCAAGGTGGTCTCCTCATGTCAGGAAAAGCGGGAACCGCAGGGATTTCACA
AAGTGGCAGGTCTCCTGACTCAGAAGCTAACTTATGAAAATGGCTTGTTAAAAATGAACTTCACGGGGGGGGACACTTGCCATAAGGTTT
ATCAGCGCTCCACAGCCATCTTCTTCTACTGTGACCGCGGCACCCAGCGGCCAGTATTTCTAAAGGAGACTTCAGATTGTTCCTACTTGT
TTGAGTGGCGAACGCAGTATGCCTGCCCACCTTTCGATCTGACTGAATGTTCATTCAAAGATGGGGCTGGCAACTCCTTCGACCTCTCGT
CCCTGTCAAGGTACAGTGACAACTGGGAAGCCATCACTGGGACGGGGGACCCGGAGCACTACCTCATCAATGTCTGCAAGTCTCTGGCCC
CGCAGGCTGGCACTGAGCCGTGCCCTCCAGAAGCAGCCGCGTGTCTGCTGGGTGGCTCCAAGCCCGTGAACCTCGGCAGGGTAAGGGACG
GACCTCAGTGGAGAGATGGCATAATTGTCCTGAAATACGTTGATGGCGACTTATGTCCAGATGGGATTCGGAAAAAGTCAACCACCATCC
GATTCACCTGCAGCGAGAGCCAAGTGAACTCCAGGCCCATGTTCATCAGCGCCGTGGAGGACTGTGAGTACACCTTTGCCTGGCCCACAG
CCACAGCCTGTCCCATGAAGAGCAACGAGCATGATGACTGCCAGGTCACCAACCCAAGCACAGGACACCTGTTTGATCTGAGCTCCTTAA
GTGGCAGGGCGGGATTCACAGCTGCTTACAGCGAGAAGGGGTTGGTTTACATGAGCATCTGTGGGGAGAATGAAAACTGCCCTCCTGGCG
TGGGGGCCTGCTTTGGACAGACCAGGATTAGCGTGGGCAAGGCCAACAAGAGGCTGAGATACGTGGACCAGGTCCTGCAGCTGGTGTACA
AGGATGGGTCCCCTTGTCCCTCCAAATCCGGCCTGAGCTATAAGAGTGTGATCAGTTTCGTGTGCAGGCCTGAGGCCAGGCCAACCAATA
GGCCCATGCTCATCTCCCTGGACAAGCAGACATGCACTCTCTTCTTCTCCTGGCACACGCCGCTGGCCTGCGAGCAAGCGACCGAATGTT
CCGTGAGGAATGGAAGCTCTATTGTTGACTTGTCTCCCCTTATTCATCGCACTGGTGGTTATGAGGCTTATGATGAGAGTGAGGATGATG
CCTCCGATACCAACCCTGATTTCTACATCAATATTTGTCAGCCACTAAATCCCATGCACGGAGTGCCCTGTCCTGCCGGAGCCGCTGTGT
GCAAAGTTCCTATTGATGGTCCCCCCATAGATATCGGCCGGGTAGCAGGACCACCAATACTCAATCCAATAGCAAATGAGATTTACTTGA
ATTTTGAAAGCAGTACTCCTTGCTTAGCGGACAAGCATTTCAACTACACCTCGCTCATCGCGTTTCACTGTAAGAGAGGTGTGAGCATGG
GAACGCCTAAGCTGTTAAGGACCAGCGAGTGCGACTTTGTGTTCGAATGGGAGACTCCTGTCGTCTGTCCTGATGAAGTGAGGATGGATG
GCTGTACCCTGACAGATGAGCAGCTCCTCTACAGCTTCAACTTGTCCAGCCTTTCCACGAGCACCTTTAAGGTGACTCGCGACTCGCGCA
CCTACAGCGTTGGGGTGTGCACCTTTGCAGTCGGGCCAGAACAAGGAGGCTGTAAGGACGGAGGAGTCTGTCTGCTCTCAGGCACCAAGG
GGGCATCCTTTGGACGGCTGCAATCAATGAAACTGGATTACAGGCACCAGGATGAAGCGGTCGTTTTAAGTTACGTGAATGGTGATCGTT
GCCCTCCAGAAACCGATGACGGCGTCCCCTGTGTCTTCCCCTTCATATTCAATGGGAAGAGCTACGAGGAGTGCATCATAGAGAGCAGGG
CGAAGCTGTGGTGTAGCACAACTGCGGACTACGACAGAGACCACGAGTGGGGCTTCTGCAGACACTCAAACAGCTACCGGACATCCAGCA
TCATATTTAAGTGTGATGAAGATGAGGACATTGGGAGGCCACAAGTCTTCAGTGAAGTGCGTGGGTGTGATGTGACATTTGAGTGGAAAA
CAAAAGTTGTCTGCCCTCCAAAGAAGTTGGAGTGCAAATTCGTCCAGAAACACAAAACCTACGACCTGCGGCTGCTCTCCTCTCTCACCG
GGTCCTGGTCCCTCGTCCACAACGGAGTCTCGTACTATATAAATCTGTGCCAGAAAATATATAAAGGGCCCCTGGGCTGCTCTGAAAGGG
CCAGCATTTGCAGAAGGACCACAACTGGTGACGTCCAGGTCCTGGGACTCGTTCACACGCAGAAGCTGGGTGTCATAGGTGACAAAGTTG
TTGTCACGTACTCCAAAGGTTATCCGTGTGGTGGAAATAAGACCGCATCCTCCGTGATAGAATTGACCTGTACAAAGACGGTGGGCAGAC
CTGCATTCAAGAGGTTTGATATCGACAGCTGCACTTACTACTTCAGCTGGGACTCCCGGGCTGCCTGCGCCGTGAAGCCTCAGGAGGTGC
AGATGGTGAATGGGACCATCACCAACCCTATAAATGGCAAGAGCTTCAGCCTCGGAGATATTTATTTTAAGCTGTTCAGAGCCTCTGGGG
ACATGAGGACCAATGGGGACAACTACCTGTATGAGATCCAACTTTCCTCCATCACAAGCTCCAGAAACCCGGCGTGCTCTGGAGCCAACA
TATGCCAGGTGAAGCCCAACGATCAGCACTTCAGTCGGAAAGTTGGAACCTCTGACAAGACCAAGTACTACCTTCAAGACGGCGATCTCG
ATGTCGTGTTTGCCTCTTCCTCTAAGTGCGGAAAGGATAAGACCAAGTCTGTTTCTTCCACCATCTTCTTCCACTGTGACCCTCTGGTGG
AGGACGGGATCCCCGAGTTCAGTCACGAGACTGCCGACTGCCAGTACCTCTTCTCTTGGTACACCTCAGCCGTGTGTCCTCTGGGGGTGG
GCTTTGACAGCGAGAATCCCGGGGACGACGGGCAGATGCACAAGGGGCTGTCAGAACGGAGCCAGGCAGTCGGCGCGGTGCTCAGCCTGC
TGCTGGTGGCGCTCACCTGCTGCCTGCTGGCCCTGTTGCTCTACAAGAAGGAGAGGAGGGAAACAGTGATAAGTAAGCTGACCACTTGCT
GTAGGAGAAGTTCCAACGTGTCCTACAAATACTCAAAGGTGAATAAGGAAGAAGAGACAGATGAGAATGAAACAGAGTGGCTGATGGAAG
AGATCCAGCTGCCTCCTCCACGGCAGGGAAAGGAAGGGCAGGAGAACGGCCATATTACCACCAAGTCAGTGAAAGCCCTCAGCTCCCTGC
ATGGGGATGACCAGGACAGTGAGGATGAGGTTCTGACCATCCCAGAGGTGAAAGTTCACTCGGGCAGGGGAGCTGGGGCAGAGAGCTCCC
ACCCAGTGAGAAACGCACAGAGCAATGCCCTTCAGGAGCGTGAGGACGATAGGGTGGGGCTGGTCAGGGGTGAGAAGGCGAGGAAAGGGA
AGTCCAGCTCTGCACAGCAGAAGACAGTGAGCTCCACCAAGCTGGTGTCCTTCCATGACGACAGCGACGAGGACCTCTTACACATCTGAC
TCCGCAGTGCCTGCAGGGGAGCACGGAGCCGCGGGACAGCCAAGCACCTCCAACCAAATAAGACTTCCACTCGATGATGCTTCTATAATT
TTGCCTTTAACAGAAACTTTCAAAAGGGAAGAGTTTTTGTGATGGGGGAGAGGGTGAAGGAGGTCAGGCCCCACTCCTTCCTGATTGTTT
ACAGTCATTGGAATAAGGCATGGCTCAGATCGGCCACAGGGCGGTACCTTGTGCCCAGGGTTTTGCCCCAAGTCCTCATTTAAAAGCATA
AGGCCGGACGCATCTCAAAACAGAGGGCTGCATTCGAAGAAACCCTTGCTGCTTTAGTCCCGATAGGGTATTTGACCCCGATATATTTTA
GCATTTTAATTCTCTCCCCCTATTTATTGACTTTGACAATTACTCAGGTTTGAGAAAAAGGAAAAAAAAACAGCCACCGTTTCTTCCTGC
CAGCAGGGGTGTGATGTACCAGTTTGTCCATCTTGAGATGGTGAGGCTGTCAGTGTATGGGGCAGCTTCCGGCGGGATGTTGAACTGGTC
ATTAATGTGTCCCCTGAGTTGGAGCTCATTCTGTCTCTTTTCTCTTTTGCTTTCTGTTTCTTAAGGGCACACACACGTGCGTGCGAGCAC
ACACACACATACGTGCACAGGGTCCCCGAGTGCCTAGGTTTTGGAGAGTTTGCCTGTTCTATGCCTTTAGTCAGGAATGGCTGCACCTTT
TTGCATGATATCTTCAAGCCTGGGCGTACAGAGCACATTTGTCAGTATTTTTGCCGGCTGGTGAATTCAAACAACCTGCCCAAAGATTGA
TTTGTGTGTTTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGAGTGGAGTTGAGGTGTCAGAGAAAATGAATTTTTTCCAGATTTGGG
GTATAGGTCTCATCTCTTCAGGTTCTCATGATACCACCTTTACTGTGCTTATTTTTTTAAGAAAAAAGTGTTGATCAACCATTCGACCTA
TAAGAAGCCTTAATTTGCACAGTGTGTGACTTACAGAAACTGCATGAAAAATCATGGGCCAGAGCCTCGGCCCTAGCATTGCACTTGGCC
TCATGCTGGAGGGAGGCTGGGCGGGTACAGCGCGGAGGAGGAGGGAGGCCAGGCGGGCATGGCGTGGAGGAGGAGGGAGGCCGGGCGGTC
ACAGCATGGAGGAGGAGGGAGGCGCTGCTGGTGTTCTTATTCTGGCGGCAGCGCCTTTCCTGCCATGTTTAGTGAATGACTTTTCTCGCA
TTGTAGAATTGTATATAGACTCTGGTGTTCTATTGCTGAGAAGCAAACCGCCCTGCAGCATCCCTCAGCCTGTACCGGTTTGGCTGGCTT
GTTTGATTTCAACATGAGTGTATTTTTTAAAATTGATTTTTCTCTTCATTTTTTTTTCAATCAACTTTACTGTAATATAAAGTATTCAAC

>28118_28118_1_EZR-IGF2R_EZR_chr6_159239114_ENST00000337147_IGF2R_chr6_160445604_ENST00000356956_length(amino acids)=2348AA_BP=28
MGQRLRCCWIVVFSGIEDTHQKPKMPKPVPCYVFDEELRKHDLNPLIKLSGAYLVDDSDPDTSLFINVCRDIDTLRDPGSQLRACPPGTA
ACLVRGHQAFDVGQPRDGLKLVRKDRLVLSYVREEAGKLDFCDGHSPAVTITFVCPSERREGTIPKLTAKSNCRYEIEWITEYACHRDYL
ESKTCSLSGEQQDVSIDLTPLAQSGGSSYISDGKEYLFYLNVCGETEIQFCNKKQAAVCQVKKSDTSQVKAAGRYHNQTLRYSDGDLTLI
YFGGDECSSGFQRMSVINFECNKTAGNDGKGTPVFTGEVDCTYFFTWDTEYACVKEKEDLLCGATDGKKRYDLSALVRHAEPEQNWEAVD
GSQTETEKKHFFINICHRVLQEGKARGCPEDAAVCAVDKNGSKNLGKFISSPMKEKGNIQLSYSDGDDCGHGKKIKTNITLVCKPGDLES
APVLRTSGEGGCFYEFEWHTAAACVLSKTEGENCTVFDSQAGFSFDLSPLTKKNGAYKVETKKYDFYINVCGPVSVSPCQPDSGACQVAK
SDEKTWNLGLSNAKLSYYDGMIQLNYRGGTPYNNERHTPRATLITFLCDRDAGVGFPEYQEEDNSTYNFRWYTSYACPEEPLECVVTDPS
TLEQYDLSSLAKSEGGLGGNWYAMDNSGEHVTWRKYYINVCRPLNPVPGCNRYASACQMKYEKDQGSFTEVVSISNLGMAKTGPVVEDSG
SLLLEYVNGSACTTSDGRQTTYTTRIHLVCSRGRLNSHPIFSLNWECVVSFLWNTEAACPIQTTTDTDQACSIRDPNSGFVFNLNPLNSS
QGYNVSGIGKIFMFNVCGTMPVCGTILGKPASGCEAETQTEELKNWKPARPVGIEKSLQLSTEGFITLTYKGPLSAKGTADAFIVRFVCN
DDVYSGPLKFLHQDIDSGQGIRNTYFEFETALACVPSPVDCQVTDLAGNEYDLTGLSTVRKPWTAVDTSVDGRKRTFYLSVCNPLPYIPG
CQGSAVGSCLVSEGNSWNLGVVQMSPQAAANGSLSIMYVNGDKCGNQRFSTRITFECAQISGSPAFQLQDGCEYVFIWRTVEACPVVRVE
GDNCEVKDPRHGNLYDLKPLGLNDTIVSAGEYTYYFRVCGKLSSDVCPTSDKSKVVSSCQEKREPQGFHKVAGLLTQKLTYENGLLKMNF
TGGDTCHKVYQRSTAIFFYCDRGTQRPVFLKETSDCSYLFEWRTQYACPPFDLTECSFKDGAGNSFDLSSLSRYSDNWEAITGTGDPEHY
LINVCKSLAPQAGTEPCPPEAAACLLGGSKPVNLGRVRDGPQWRDGIIVLKYVDGDLCPDGIRKKSTTIRFTCSESQVNSRPMFISAVED
CEYTFAWPTATACPMKSNEHDDCQVTNPSTGHLFDLSSLSGRAGFTAAYSEKGLVYMSICGENENCPPGVGACFGQTRISVGKANKRLRY
VDQVLQLVYKDGSPCPSKSGLSYKSVISFVCRPEARPTNRPMLISLDKQTCTLFFSWHTPLACEQATECSVRNGSSIVDLSPLIHRTGGY
EAYDESEDDASDTNPDFYINICQPLNPMHGVPCPAGAAVCKVPIDGPPIDIGRVAGPPILNPIANEIYLNFESSTPCLADKHFNYTSLIA
FHCKRGVSMGTPKLLRTSECDFVFEWETPVVCPDEVRMDGCTLTDEQLLYSFNLSSLSTSTFKVTRDSRTYSVGVCTFAVGPEQGGCKDG
GVCLLSGTKGASFGRLQSMKLDYRHQDEAVVLSYVNGDRCPPETDDGVPCVFPFIFNGKSYEECIIESRAKLWCSTTADYDRDHEWGFCR
HSNSYRTSSIIFKCDEDEDIGRPQVFSEVRGCDVTFEWKTKVVCPPKKLECKFVQKHKTYDLRLLSSLTGSWSLVHNGVSYYINLCQKIY
KGPLGCSERASICRRTTTGDVQVLGLVHTQKLGVIGDKVVVTYSKGYPCGGNKTASSVIELTCTKTVGRPAFKRFDIDSCTYYFSWDSRA
ACAVKPQEVQMVNGTITNPINGKSFSLGDIYFKLFRASGDMRTNGDNYLYEIQLSSITSSRNPACSGANICQVKPNDQHFSRKVGTSDKT
KYYLQDGDLDVVFASSSKCGKDKTKSVSSTIFFHCDPLVEDGIPEFSHETADCQYLFSWYTSAVCPLGVGFDSENPGDDGQMHKGLSERS
QAVGAVLSLLLVALTCCLLALLLYKKERRETVISKLTTCCRRSSNVSYKYSKVNKEEETDENETEWLMEEIQLPPPRQGKEGQENGHITT
KSVKALSSLHGDDQDSEDEVLTIPEVKVHSGRGAGAESSHPVRNAQSNALQEREDDRVGLVRGEKARKGKSSSAQQKTVSSTKLVSFHDD

--------------------------------------------------------------
>28118_28118_2_EZR-IGF2R_EZR_chr6_159239114_ENST00000392177_IGF2R_chr6_160445604_ENST00000356956_length(transcript)=8582nt_BP=152nt
GTGTCGGGCGCGGCAGGAGGACGAGGCAGGGCGGGCGGGCGCTCTAAGGGTTCTGCTCTGACTCCAGGTTGGGACAGCGTCTTCGCTGCT
GCTGGATAGTCGTGTTTTCGGGGATCGAGGATACTCACCAGAAACCGAAAATGCCGAAACCAGTGCCATGCTATGTGTTTGATGAAGAGT
TGAGGAAGCATGATCTCAATCCTCTGATCAAGCTTAGTGGTGCCTACTTGGTGGATGACTCCGATCCGGACACTTCTCTATTCATCAATG
TTTGTAGAGACATAGACACACTACGAGACCCAGGTTCACAGCTGCGGGCCTGTCCCCCCGGCACTGCCGCCTGCCTGGTAAGAGGACACC
AGGCGTTTGATGTTGGCCAGCCCCGGGACGGACTGAAGCTGGTGCGCAAGGACAGGCTTGTCCTGAGTTACGTGAGGGAAGAGGCAGGAA
AGCTAGACTTTTGTGATGGTCACAGCCCTGCGGTGACTATTACATTTGTTTGCCCGTCGGAGCGGAGAGAGGGCACCATTCCCAAACTCA
CAGCTAAATCCAACTGCCGCTATGAAATTGAGTGGATTACTGAGTATGCCTGCCACAGAGATTACCTGGAAAGTAAAACTTGTTCTCTGA
GCGGCGAGCAGCAGGATGTCTCCATAGACCTCACACCACTTGCCCAGAGCGGAGGTTCATCCTATATTTCAGATGGAAAAGAATATTTGT
TTTATTTGAATGTCTGTGGAGAAACTGAAATACAGTTCTGTAATAAAAAACAAGCTGCAGTTTGCCAAGTGAAAAAGAGCGATACCTCTC
AAGTCAAAGCAGCAGGAAGATACCACAATCAGACCCTCCGATATTCGGATGGAGACCTCACCTTGATATATTTTGGAGGTGATGAATGCA
GCTCAGGGTTTCAGCGGATGAGCGTCATAAACTTTGAGTGCAATAAAACCGCAGGTAACGATGGGAAAGGAACTCCTGTATTCACAGGGG
AGGTTGACTGCACCTACTTCTTCACATGGGACACGGAATACGCCTGTGTTAAGGAGAAGGAAGACCTCCTCTGCGGTGCCACCGACGGGA
AGAAGCGCTATGACCTGTCCGCGCTGGTCCGCCATGCAGAACCAGAGCAGAATTGGGAAGCTGTGGATGGCAGTCAGACGGAAACAGAGA
AGAAGCATTTTTTCATTAATATTTGTCACAGAGTGCTGCAGGAAGGCAAGGCACGAGGGTGTCCCGAGGACGCGGCAGTGTGTGCAGTGG
ATAAAAATGGAAGTAAAAATCTGGGAAAATTTATTTCCTCTCCCATGAAAGAGAAAGGAAACATTCAACTCTCTTATTCAGATGGTGATG
ATTGTGGTCATGGCAAGAAAATTAAAACTAATATCACACTTGTATGCAAGCCAGGTGATCTGGAAAGTGCACCAGTGTTGAGAACTTCTG
GGGAAGGCGGTTGCTTTTATGAGTTTGAGTGGCACACAGCTGCGGCCTGTGTGCTGTCTAAGACAGAAGGGGAGAACTGCACGGTCTTTG
ACTCCCAGGCAGGGTTTTCTTTTGACTTATCACCTCTCACAAAGAAAAATGGTGCCTATAAAGTTGAGACAAAGAAGTATGACTTTTATA
TAAATGTGTGTGGCCCGGTGTCTGTGAGCCCCTGTCAGCCAGACTCAGGAGCCTGCCAGGTGGCAAAAAGTGATGAGAAGACTTGGAACT
TGGGTCTGAGTAATGCGAAGCTTTCATATTATGATGGGATGATCCAACTGAACTACAGAGGCGGCACACCCTATAACAATGAAAGACACA
CACCGAGAGCTACGCTCATCACCTTTCTCTGTGATCGAGACGCGGGAGTGGGCTTCCCTGAATATCAGGAAGAGGATAACTCCACCTACA
ACTTCCGGTGGTACACCAGCTATGCCTGCCCGGAGGAGCCCCTGGAATGCGTAGTGACCGACCCCTCCACGCTGGAGCAGTACGACCTCT
CCAGTCTGGCAAAATCTGAAGGTGGCCTTGGAGGAAACTGGTATGCCATGGACAACTCAGGGGAACATGTCACGTGGAGGAAATACTACA
TTAACGTGTGTCGGCCTCTGAATCCAGTGCCGGGCTGCAACCGATATGCATCGGCTTGCCAGATGAAGTATGAAAAAGATCAGGGCTCCT
TCACTGAAGTGGTTTCCATCAGTAACTTGGGAATGGCAAAGACCGGCCCGGTGGTTGAGGACAGCGGCAGCCTCCTTCTGGAATACGTGA
ATGGGTCGGCCTGCACCACCAGCGATGGCAGACAGACCACATATACCACGAGGATCCATCTCGTCTGCTCCAGGGGCAGGCTGAACAGCC
ACCCCATCTTTTCTCTCAACTGGGAGTGTGTGGTCAGTTTCCTGTGGAACACAGAGGCTGCCTGTCCCATTCAGACAACGACGGATACAG
ACCAGGCTTGCTCTATAAGGGATCCCAACAGTGGATTTGTGTTTAATCTTAATCCGCTAAACAGTTCGCAAGGATATAACGTCTCTGGCA
TTGGGAAGATTTTTATGTTTAATGTCTGCGGCACAATGCCTGTCTGTGGGACCATCCTGGGAAAACCTGCTTCTGGCTGTGAGGCAGAAA
CCCAAACTGAAGAGCTCAAGAATTGGAAGCCAGCAAGGCCAGTCGGAATTGAGAAAAGCCTCCAGCTGTCCACAGAGGGCTTCATCACTC
TGACCTACAAAGGGCCTCTCTCTGCCAAAGGTACCGCTGATGCTTTTATCGTCCGCTTTGTTTGCAATGATGATGTTTACTCAGGGCCCC
TCAAATTCCTGCATCAAGATATCGACTCTGGGCAAGGGATCCGAAACACTTACTTTGAGTTTGAAACCGCGTTGGCCTGTGTTCCTTCTC
CAGTGGACTGCCAAGTCACCGACCTGGCTGGAAATGAGTACGACCTGACTGGCCTAAGCACAGTCAGGAAACCTTGGACGGCTGTTGACA
CCTCTGTCGATGGGAGAAAGAGGACTTTCTATTTGAGCGTTTGCAATCCTCTCCCTTACATTCCTGGATGCCAGGGCAGCGCAGTGGGGT
CTTGCTTAGTGTCAGAAGGCAATAGCTGGAATCTGGGTGTGGTGCAGATGAGTCCCCAAGCCGCGGCGAATGGATCTTTGAGCATCATGT
ATGTCAACGGTGACAAGTGTGGGAACCAGCGCTTCTCCACCAGGATCACGTTTGAGTGTGCTCAGATATCGGGCTCACCAGCATTTCAGC
TTCAGGATGGTTGTGAGTACGTGTTTATCTGGAGAACTGTGGAAGCCTGTCCCGTTGTCAGAGTGGAAGGGGACAACTGTGAGGTGAAAG
ACCCAAGGCATGGCAACTTGTATGACCTGAAGCCCCTGGGCCTCAACGACACCATCGTGAGCGCTGGCGAATACACTTATTACTTCCGGG
TCTGTGGGAAGCTTTCCTCAGACGTCTGCCCCACAAGTGACAAGTCCAAGGTGGTCTCCTCATGTCAGGAAAAGCGGGAACCGCAGGGAT
TTCACAAAGTGGCAGGTCTCCTGACTCAGAAGCTAACTTATGAAAATGGCTTGTTAAAAATGAACTTCACGGGGGGGGACACTTGCCATA
AGGTTTATCAGCGCTCCACAGCCATCTTCTTCTACTGTGACCGCGGCACCCAGCGGCCAGTATTTCTAAAGGAGACTTCAGATTGTTCCT
ACTTGTTTGAGTGGCGAACGCAGTATGCCTGCCCACCTTTCGATCTGACTGAATGTTCATTCAAAGATGGGGCTGGCAACTCCTTCGACC
TCTCGTCCCTGTCAAGGTACAGTGACAACTGGGAAGCCATCACTGGGACGGGGGACCCGGAGCACTACCTCATCAATGTCTGCAAGTCTC
TGGCCCCGCAGGCTGGCACTGAGCCGTGCCCTCCAGAAGCAGCCGCGTGTCTGCTGGGTGGCTCCAAGCCCGTGAACCTCGGCAGGGTAA
GGGACGGACCTCAGTGGAGAGATGGCATAATTGTCCTGAAATACGTTGATGGCGACTTATGTCCAGATGGGATTCGGAAAAAGTCAACCA
CCATCCGATTCACCTGCAGCGAGAGCCAAGTGAACTCCAGGCCCATGTTCATCAGCGCCGTGGAGGACTGTGAGTACACCTTTGCCTGGC
CCACAGCCACAGCCTGTCCCATGAAGAGCAACGAGCATGATGACTGCCAGGTCACCAACCCAAGCACAGGACACCTGTTTGATCTGAGCT
CCTTAAGTGGCAGGGCGGGATTCACAGCTGCTTACAGCGAGAAGGGGTTGGTTTACATGAGCATCTGTGGGGAGAATGAAAACTGCCCTC
CTGGCGTGGGGGCCTGCTTTGGACAGACCAGGATTAGCGTGGGCAAGGCCAACAAGAGGCTGAGATACGTGGACCAGGTCCTGCAGCTGG
TGTACAAGGATGGGTCCCCTTGTCCCTCCAAATCCGGCCTGAGCTATAAGAGTGTGATCAGTTTCGTGTGCAGGCCTGAGGCCAGGCCAA
CCAATAGGCCCATGCTCATCTCCCTGGACAAGCAGACATGCACTCTCTTCTTCTCCTGGCACACGCCGCTGGCCTGCGAGCAAGCGACCG
AATGTTCCGTGAGGAATGGAAGCTCTATTGTTGACTTGTCTCCCCTTATTCATCGCACTGGTGGTTATGAGGCTTATGATGAGAGTGAGG
ATGATGCCTCCGATACCAACCCTGATTTCTACATCAATATTTGTCAGCCACTAAATCCCATGCACGGAGTGCCCTGTCCTGCCGGAGCCG
CTGTGTGCAAAGTTCCTATTGATGGTCCCCCCATAGATATCGGCCGGGTAGCAGGACCACCAATACTCAATCCAATAGCAAATGAGATTT
ACTTGAATTTTGAAAGCAGTACTCCTTGCTTAGCGGACAAGCATTTCAACTACACCTCGCTCATCGCGTTTCACTGTAAGAGAGGTGTGA
GCATGGGAACGCCTAAGCTGTTAAGGACCAGCGAGTGCGACTTTGTGTTCGAATGGGAGACTCCTGTCGTCTGTCCTGATGAAGTGAGGA
TGGATGGCTGTACCCTGACAGATGAGCAGCTCCTCTACAGCTTCAACTTGTCCAGCCTTTCCACGAGCACCTTTAAGGTGACTCGCGACT
CGCGCACCTACAGCGTTGGGGTGTGCACCTTTGCAGTCGGGCCAGAACAAGGAGGCTGTAAGGACGGAGGAGTCTGTCTGCTCTCAGGCA
CCAAGGGGGCATCCTTTGGACGGCTGCAATCAATGAAACTGGATTACAGGCACCAGGATGAAGCGGTCGTTTTAAGTTACGTGAATGGTG
ATCGTTGCCCTCCAGAAACCGATGACGGCGTCCCCTGTGTCTTCCCCTTCATATTCAATGGGAAGAGCTACGAGGAGTGCATCATAGAGA
GCAGGGCGAAGCTGTGGTGTAGCACAACTGCGGACTACGACAGAGACCACGAGTGGGGCTTCTGCAGACACTCAAACAGCTACCGGACAT
CCAGCATCATATTTAAGTGTGATGAAGATGAGGACATTGGGAGGCCACAAGTCTTCAGTGAAGTGCGTGGGTGTGATGTGACATTTGAGT
GGAAAACAAAAGTTGTCTGCCCTCCAAAGAAGTTGGAGTGCAAATTCGTCCAGAAACACAAAACCTACGACCTGCGGCTGCTCTCCTCTC
TCACCGGGTCCTGGTCCCTCGTCCACAACGGAGTCTCGTACTATATAAATCTGTGCCAGAAAATATATAAAGGGCCCCTGGGCTGCTCTG
AAAGGGCCAGCATTTGCAGAAGGACCACAACTGGTGACGTCCAGGTCCTGGGACTCGTTCACACGCAGAAGCTGGGTGTCATAGGTGACA
AAGTTGTTGTCACGTACTCCAAAGGTTATCCGTGTGGTGGAAATAAGACCGCATCCTCCGTGATAGAATTGACCTGTACAAAGACGGTGG
GCAGACCTGCATTCAAGAGGTTTGATATCGACAGCTGCACTTACTACTTCAGCTGGGACTCCCGGGCTGCCTGCGCCGTGAAGCCTCAGG
AGGTGCAGATGGTGAATGGGACCATCACCAACCCTATAAATGGCAAGAGCTTCAGCCTCGGAGATATTTATTTTAAGCTGTTCAGAGCCT
CTGGGGACATGAGGACCAATGGGGACAACTACCTGTATGAGATCCAACTTTCCTCCATCACAAGCTCCAGAAACCCGGCGTGCTCTGGAG
CCAACATATGCCAGGTGAAGCCCAACGATCAGCACTTCAGTCGGAAAGTTGGAACCTCTGACAAGACCAAGTACTACCTTCAAGACGGCG
ATCTCGATGTCGTGTTTGCCTCTTCCTCTAAGTGCGGAAAGGATAAGACCAAGTCTGTTTCTTCCACCATCTTCTTCCACTGTGACCCTC
TGGTGGAGGACGGGATCCCCGAGTTCAGTCACGAGACTGCCGACTGCCAGTACCTCTTCTCTTGGTACACCTCAGCCGTGTGTCCTCTGG
GGGTGGGCTTTGACAGCGAGAATCCCGGGGACGACGGGCAGATGCACAAGGGGCTGTCAGAACGGAGCCAGGCAGTCGGCGCGGTGCTCA
GCCTGCTGCTGGTGGCGCTCACCTGCTGCCTGCTGGCCCTGTTGCTCTACAAGAAGGAGAGGAGGGAAACAGTGATAAGTAAGCTGACCA
CTTGCTGTAGGAGAAGTTCCAACGTGTCCTACAAATACTCAAAGGTGAATAAGGAAGAAGAGACAGATGAGAATGAAACAGAGTGGCTGA
TGGAAGAGATCCAGCTGCCTCCTCCACGGCAGGGAAAGGAAGGGCAGGAGAACGGCCATATTACCACCAAGTCAGTGAAAGCCCTCAGCT
CCCTGCATGGGGATGACCAGGACAGTGAGGATGAGGTTCTGACCATCCCAGAGGTGAAAGTTCACTCGGGCAGGGGAGCTGGGGCAGAGA
GCTCCCACCCAGTGAGAAACGCACAGAGCAATGCCCTTCAGGAGCGTGAGGACGATAGGGTGGGGCTGGTCAGGGGTGAGAAGGCGAGGA
AAGGGAAGTCCAGCTCTGCACAGCAGAAGACAGTGAGCTCCACCAAGCTGGTGTCCTTCCATGACGACAGCGACGAGGACCTCTTACACA
TCTGACTCCGCAGTGCCTGCAGGGGAGCACGGAGCCGCGGGACAGCCAAGCACCTCCAACCAAATAAGACTTCCACTCGATGATGCTTCT
ATAATTTTGCCTTTAACAGAAACTTTCAAAAGGGAAGAGTTTTTGTGATGGGGGAGAGGGTGAAGGAGGTCAGGCCCCACTCCTTCCTGA
TTGTTTACAGTCATTGGAATAAGGCATGGCTCAGATCGGCCACAGGGCGGTACCTTGTGCCCAGGGTTTTGCCCCAAGTCCTCATTTAAA
AGCATAAGGCCGGACGCATCTCAAAACAGAGGGCTGCATTCGAAGAAACCCTTGCTGCTTTAGTCCCGATAGGGTATTTGACCCCGATAT
ATTTTAGCATTTTAATTCTCTCCCCCTATTTATTGACTTTGACAATTACTCAGGTTTGAGAAAAAGGAAAAAAAAACAGCCACCGTTTCT
TCCTGCCAGCAGGGGTGTGATGTACCAGTTTGTCCATCTTGAGATGGTGAGGCTGTCAGTGTATGGGGCAGCTTCCGGCGGGATGTTGAA
CTGGTCATTAATGTGTCCCCTGAGTTGGAGCTCATTCTGTCTCTTTTCTCTTTTGCTTTCTGTTTCTTAAGGGCACACACACGTGCGTGC
GAGCACACACACACATACGTGCACAGGGTCCCCGAGTGCCTAGGTTTTGGAGAGTTTGCCTGTTCTATGCCTTTAGTCAGGAATGGCTGC
ACCTTTTTGCATGATATCTTCAAGCCTGGGCGTACAGAGCACATTTGTCAGTATTTTTGCCGGCTGGTGAATTCAAACAACCTGCCCAAA
GATTGATTTGTGTGTTTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGAGTGGAGTTGAGGTGTCAGAGAAAATGAATTTTTTCCAGA
TTTGGGGTATAGGTCTCATCTCTTCAGGTTCTCATGATACCACCTTTACTGTGCTTATTTTTTTAAGAAAAAAGTGTTGATCAACCATTC
GACCTATAAGAAGCCTTAATTTGCACAGTGTGTGACTTACAGAAACTGCATGAAAAATCATGGGCCAGAGCCTCGGCCCTAGCATTGCAC
TTGGCCTCATGCTGGAGGGAGGCTGGGCGGGTACAGCGCGGAGGAGGAGGGAGGCCAGGCGGGCATGGCGTGGAGGAGGAGGGAGGCCGG
GCGGTCACAGCATGGAGGAGGAGGGAGGCGCTGCTGGTGTTCTTATTCTGGCGGCAGCGCCTTTCCTGCCATGTTTAGTGAATGACTTTT
CTCGCATTGTAGAATTGTATATAGACTCTGGTGTTCTATTGCTGAGAAGCAAACCGCCCTGCAGCATCCCTCAGCCTGTACCGGTTTGGC
TGGCTTGTTTGATTTCAACATGAGTGTATTTTTTAAAATTGATTTTTCTCTTCATTTTTTTTTCAATCAACTTTACTGTAATATAAAGTA

>28118_28118_2_EZR-IGF2R_EZR_chr6_159239114_ENST00000392177_IGF2R_chr6_160445604_ENST00000356956_length(amino acids)=2348AA_BP=28
MGQRLRCCWIVVFSGIEDTHQKPKMPKPVPCYVFDEELRKHDLNPLIKLSGAYLVDDSDPDTSLFINVCRDIDTLRDPGSQLRACPPGTA
ACLVRGHQAFDVGQPRDGLKLVRKDRLVLSYVREEAGKLDFCDGHSPAVTITFVCPSERREGTIPKLTAKSNCRYEIEWITEYACHRDYL
ESKTCSLSGEQQDVSIDLTPLAQSGGSSYISDGKEYLFYLNVCGETEIQFCNKKQAAVCQVKKSDTSQVKAAGRYHNQTLRYSDGDLTLI
YFGGDECSSGFQRMSVINFECNKTAGNDGKGTPVFTGEVDCTYFFTWDTEYACVKEKEDLLCGATDGKKRYDLSALVRHAEPEQNWEAVD
GSQTETEKKHFFINICHRVLQEGKARGCPEDAAVCAVDKNGSKNLGKFISSPMKEKGNIQLSYSDGDDCGHGKKIKTNITLVCKPGDLES
APVLRTSGEGGCFYEFEWHTAAACVLSKTEGENCTVFDSQAGFSFDLSPLTKKNGAYKVETKKYDFYINVCGPVSVSPCQPDSGACQVAK
SDEKTWNLGLSNAKLSYYDGMIQLNYRGGTPYNNERHTPRATLITFLCDRDAGVGFPEYQEEDNSTYNFRWYTSYACPEEPLECVVTDPS
TLEQYDLSSLAKSEGGLGGNWYAMDNSGEHVTWRKYYINVCRPLNPVPGCNRYASACQMKYEKDQGSFTEVVSISNLGMAKTGPVVEDSG
SLLLEYVNGSACTTSDGRQTTYTTRIHLVCSRGRLNSHPIFSLNWECVVSFLWNTEAACPIQTTTDTDQACSIRDPNSGFVFNLNPLNSS
QGYNVSGIGKIFMFNVCGTMPVCGTILGKPASGCEAETQTEELKNWKPARPVGIEKSLQLSTEGFITLTYKGPLSAKGTADAFIVRFVCN
DDVYSGPLKFLHQDIDSGQGIRNTYFEFETALACVPSPVDCQVTDLAGNEYDLTGLSTVRKPWTAVDTSVDGRKRTFYLSVCNPLPYIPG
CQGSAVGSCLVSEGNSWNLGVVQMSPQAAANGSLSIMYVNGDKCGNQRFSTRITFECAQISGSPAFQLQDGCEYVFIWRTVEACPVVRVE
GDNCEVKDPRHGNLYDLKPLGLNDTIVSAGEYTYYFRVCGKLSSDVCPTSDKSKVVSSCQEKREPQGFHKVAGLLTQKLTYENGLLKMNF
TGGDTCHKVYQRSTAIFFYCDRGTQRPVFLKETSDCSYLFEWRTQYACPPFDLTECSFKDGAGNSFDLSSLSRYSDNWEAITGTGDPEHY
LINVCKSLAPQAGTEPCPPEAAACLLGGSKPVNLGRVRDGPQWRDGIIVLKYVDGDLCPDGIRKKSTTIRFTCSESQVNSRPMFISAVED
CEYTFAWPTATACPMKSNEHDDCQVTNPSTGHLFDLSSLSGRAGFTAAYSEKGLVYMSICGENENCPPGVGACFGQTRISVGKANKRLRY
VDQVLQLVYKDGSPCPSKSGLSYKSVISFVCRPEARPTNRPMLISLDKQTCTLFFSWHTPLACEQATECSVRNGSSIVDLSPLIHRTGGY
EAYDESEDDASDTNPDFYINICQPLNPMHGVPCPAGAAVCKVPIDGPPIDIGRVAGPPILNPIANEIYLNFESSTPCLADKHFNYTSLIA
FHCKRGVSMGTPKLLRTSECDFVFEWETPVVCPDEVRMDGCTLTDEQLLYSFNLSSLSTSTFKVTRDSRTYSVGVCTFAVGPEQGGCKDG
GVCLLSGTKGASFGRLQSMKLDYRHQDEAVVLSYVNGDRCPPETDDGVPCVFPFIFNGKSYEECIIESRAKLWCSTTADYDRDHEWGFCR
HSNSYRTSSIIFKCDEDEDIGRPQVFSEVRGCDVTFEWKTKVVCPPKKLECKFVQKHKTYDLRLLSSLTGSWSLVHNGVSYYINLCQKIY
KGPLGCSERASICRRTTTGDVQVLGLVHTQKLGVIGDKVVVTYSKGYPCGGNKTASSVIELTCTKTVGRPAFKRFDIDSCTYYFSWDSRA
ACAVKPQEVQMVNGTITNPINGKSFSLGDIYFKLFRASGDMRTNGDNYLYEIQLSSITSSRNPACSGANICQVKPNDQHFSRKVGTSDKT
KYYLQDGDLDVVFASSSKCGKDKTKSVSSTIFFHCDPLVEDGIPEFSHETADCQYLFSWYTSAVCPLGVGFDSENPGDDGQMHKGLSERS
QAVGAVLSLLLVALTCCLLALLLYKKERRETVISKLTTCCRRSSNVSYKYSKVNKEEETDENETEWLMEEIQLPPPRQGKEGQENGHITT
KSVKALSSLHGDDQDSEDEVLTIPEVKVHSGRGAGAESSHPVRNAQSNALQEREDDRVGLVRGEKARKGKSSSAQQKTVSSTKLVSFHDD

--------------------------------------------------------------

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Fusion Gene PPI Analysis for EZR-IGF2R


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneEZRchr6:159239114chr6:160445604ENST00000337147-113244_5864.0587.0SCYL3
HgeneEZRchr6:159239114chr6:160445604ENST00000367075-214244_5864.0587.0SCYL3


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for EZR-IGF2R


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for EZR-IGF2R


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource