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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:EZR-NMT1 (FusionGDB2 ID:28122)

Fusion Gene Summary for EZR-NMT1

check button Fusion gene summary
Fusion gene informationFusion gene name: EZR-NMT1
Fusion gene ID: 28122
HgeneTgene
Gene symbol

EZR

NMT1

Gene ID

7430

4836

Gene nameezrinN-myristoyltransferase 1
SynonymsCVIL|CVL|HEL-S-105|VIL2NMT
Cytomap

6q25.3

17q21.31

Type of geneprotein-codingprotein-coding
Descriptionezrincytovillin 2epididymis secretory protein Li 105p81villin 2 (ezrin)glycylpeptide N-tetradecanoyltransferase 1alternative, short form NMT-Slong form, NMT-Lmyristoyl-CoA:protein N-myristoyltransferase 1type I N-myristoyltransferase
Modification date2020032220200313
UniProtAcc

P15311

P30419

Ensembl transtripts involved in fusion geneENST00000337147, ENST00000367075, 
ENST00000392177, ENST00000476189, 
ENST00000590114, ENST00000258960, 
ENST00000592782, 
Fusion gene scores* DoF score26 X 22 X 10=572012 X 14 X 6=1008
# samples 3214
** MAII scorelog2(32/5720*10)=-4.15987133677839
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/1008*10)=-2.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EZR [Title/Abstract] AND NMT1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointEZR(159190357)-NMT1(43180318), # samples:1
Anticipated loss of major functional domain due to fusion event.EZR-NMT1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
EZR-NMT1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
EZR-NMT1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneEZR

GO:0048015

phosphatidylinositol-mediated signaling

25591774

HgeneEZR

GO:0051017

actin filament bundle assembly

10793131

TgeneNMT1

GO:0018008

N-terminal peptidyl-glycine N-myristoylation

25255805

TgeneNMT1

GO:0042180

cellular ketone metabolic process

22865860


check buttonFusion gene breakpoints across EZR (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NMT1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-HU-A4GJEZRchr6

159190357

-NMT1chr17

43180318

+


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Fusion Gene ORF analysis for EZR-NMT1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000337147ENST00000590114EZRchr6

159190357

-NMT1chr17

43180318

+
5CDS-intronENST00000367075ENST00000590114EZRchr6

159190357

-NMT1chr17

43180318

+
5CDS-intronENST00000392177ENST00000590114EZRchr6

159190357

-NMT1chr17

43180318

+
Frame-shiftENST00000367075ENST00000258960EZRchr6

159190357

-NMT1chr17

43180318

+
Frame-shiftENST00000367075ENST00000592782EZRchr6

159190357

-NMT1chr17

43180318

+
In-frameENST00000337147ENST00000258960EZRchr6

159190357

-NMT1chr17

43180318

+
In-frameENST00000337147ENST00000592782EZRchr6

159190357

-NMT1chr17

43180318

+
In-frameENST00000392177ENST00000258960EZRchr6

159190357

-NMT1chr17

43180318

+
In-frameENST00000392177ENST00000592782EZRchr6

159190357

-NMT1chr17

43180318

+
intron-3CDSENST00000476189ENST00000258960EZRchr6

159190357

-NMT1chr17

43180318

+
intron-3CDSENST00000476189ENST00000592782EZRchr6

159190357

-NMT1chr17

43180318

+
intron-intronENST00000476189ENST00000590114EZRchr6

159190357

-NMT1chr17

43180318

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000337147EZRchr6159190357-ENST00000592782NMT1chr1743180318+53531478621975637
ENST00000337147EZRchr6159190357-ENST00000258960NMT1chr1743180318+53461478621975637
ENST00000392177EZRchr6159190357-ENST00000592782NMT1chr1743180318+52631388681885605
ENST00000392177EZRchr6159190357-ENST00000258960NMT1chr1743180318+52561388681885605

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000337147ENST00000592782EZRchr6159190357-NMT1chr1743180318+0.0050868910.9949131
ENST00000337147ENST00000258960EZRchr6159190357-NMT1chr1743180318+0.005072790.99492717
ENST00000392177ENST00000592782EZRchr6159190357-NMT1chr1743180318+0.0035237140.99647623
ENST00000392177ENST00000258960EZRchr6159190357-NMT1chr1743180318+0.0034935290.9965064

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Fusion Genomic Features for EZR-NMT1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
EZRchr6159190357-NMT1chr1743180318+1.09E-050.99998915
EZRchr6159190357-NMT1chr1743180318+1.09E-050.99998915

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for EZR-NMT1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:159190357/chr17:43180318)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EZR

P15311

NMT1

P30419

FUNCTION: Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis. {ECO:0000269|PubMed:17881735, ECO:0000269|PubMed:18270268, ECO:0000269|PubMed:19111582}.FUNCTION: Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins. {ECO:0000269|PubMed:22865860, ECO:0000269|PubMed:25255805, ECO:0000269|PubMed:9353336, ECO:0000269|PubMed:9506952}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEZRchr6:159190357chr17:43180318ENST00000337147-11132_295448587.0DomainFERM
HgeneEZRchr6:159190357chr17:43180318ENST00000367075-12142_295448587.0DomainFERM
HgeneEZRchr6:159190357chr17:43180318ENST00000337147-1113115_120448587.0Motif[IL]-x-C-x-x-[DE] motif
HgeneEZRchr6:159190357chr17:43180318ENST00000367075-1214115_120448587.0Motif[IL]-x-C-x-x-[DE] motif

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneNMT1chr6:159190357chr17:43180318ENST0000025896071255_67331497.0Compositional biasNote=Poly-Lys
TgeneNMT1chr6:159190357chr17:43180318ENST0000059278281355_67331497.0Compositional biasNote=Poly-Lys
TgeneNMT1chr6:159190357chr17:43180318ENST00000258960712118_120331497.0RegionMyristoyl-CoA binding
TgeneNMT1chr6:159190357chr17:43180318ENST00000258960712248_250331497.0RegionMyristoyl-CoA binding
TgeneNMT1chr6:159190357chr17:43180318ENST00000258960712256_260331497.0RegionMyristoyl-CoA binding
TgeneNMT1chr6:159190357chr17:43180318ENST00000592782813118_120331497.0RegionMyristoyl-CoA binding
TgeneNMT1chr6:159190357chr17:43180318ENST00000592782813248_250331497.0RegionMyristoyl-CoA binding
TgeneNMT1chr6:159190357chr17:43180318ENST00000592782813256_260331497.0RegionMyristoyl-CoA binding


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Fusion Gene Sequence for EZR-NMT1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>28122_28122_1_EZR-NMT1_EZR_chr6_159190357_ENST00000337147_NMT1_chr17_43180318_ENST00000258960_length(transcript)=5346nt_BP=1478nt
GGCGCGGCAGGAGGACGAGGCAGGGCGGGCGGGCGCTCTAAGGGTTCTGCTCTGACTCCAGGTTGGGACAGCGTCTTCGCTGCTGCTGGA
TAGTCGTGTTTTCGGGGATCGAGGATACTCACCAGAAACCGAAAATGCCGAAACCAATCAATGTCCGAGTTACCACCATGGATGCAGAGC
TGGAGTTTGCAATCCAGCCAAATACAACTGGAAAACAGCTTTTTGATCAGGTGGTAAAGACTATCGGCCTCCGGGAAGTGTGGTACTTTG
GCCTCCACTATGTGGATAATAAAGGATTTCCTACCTGGCTGAAGCTGGATAAGAAGGTGTCTGCCCAGGAGGTCAGGAAGGAGAATCCCC
TCCAGTTCAAGTTCCGGGCCAAGTTCTACCCTGAAGATGTGGCTGAGGAGCTCATCCAGGACATCACCCAGAAACTTTTCTTCCTCCAAG
TGAAGGAAGGAATCCTTAGCGATGAGATCTACTGCCCCCCTGAGACTGCCGTGCTCTTGGGGTCCTACGCTGTGCAGGCCAAGTTTGGGG
ACTACAACAAAGAAGTGCACAAGTCTGGGTACCTCAGCTCTGAGCGGCTGATCCCTCAAAGAGTGATGGACCAGCACAAACTTACCAGGG
ACCAGTGGGAGGACCGGATCCAGGTGTGGCATGCGGAACACCGTGGGATGCTCAAAGATAATGCTATGTTGGAATACCTGAAGATTGCTC
AGGACCTGGAAATGTATGGAATCAACTATTTCGAGATAAAAAACAAGAAAGGAACAGACCTTTGGCTTGGAGTTGATGCCCTTGGACTGA
ATATTTATGAGAAAGATGATAAGTTAACCCCAAAGATTGGCTTTCCTTGGAGTGAAATCAGGAACATCTCTTTCAATGACAAAAAGTTTG
TCATTAAACCCATCGACAAGAAGGCACCTGACTTTGTGTTTTATGCCCCACGTCTGAGAATCAACAAGCGGATCCTGCAGCTCTGCATGG
GCAACCATGAGTTGTATATGCGCCGCAGGAAGCCTGACACCATCGAGGTGCAGCAGATGAAGGCCCAGGCCCGGGAGGAGAAGCATCAGA
AGCAGCTGGAGCGGCAACAGCTGGAAACAGAGAAGAAAAGGAGAGAAACCGTGGAGAGAGAGAAAGAGCAGATGATGCGCGAGAAGGAGG
AGTTGATGCTGCGGCTGCAGGACTATGAGGAGAAGACAAAGAAGGCAGAGAGAGAGCTCTCGGAGCAGATTCAGAGGGCCCTGCAGCTGG
AGGAGGAGAGGAAGCGGGCACAGGAGGAGGCCGAGCGCCTAGAGGCTGACCGTATGGCTGCACTGCGGGCTAAGGAGGAGCTGGAGAGAC
AGGCGGTGGATCAGATAAAGAGCCAGGAGCAGCTGGCTGCGGAGCTTGCAGAATACACTGCCAAGATTGCCCTCCTGGAAGAGGCGCGGA
GGCGCAAGGAGGATGAAGTTGAAGAGTGGCAGCACAGGACTCCCAAGACAGCTGGGCTGCGACCAATGGAAACAAAGGACATTCCAGTAG
TGCACCAGCTCCTCACCAGGTACTTGAAGCAATTTCACCTTACGCCCGTCATGAGCCAGGAGGAGGTGGAGCACTGGTTCTACCCCCAGG
AGAATATCATCGACACTTTCGTGGTGGAGAACGCAAACGGAGAGGTGACAGATTTCCTGAGCTTTTATACGCTGCCCTCCACCATCATGA
ACCATCCAACCCACAAGAGTCTCAAAGCTGCTTATTCTTTCTACAACGTTCACACCCAGACCCCTCTTCTAGACCTCATGAGCGACGCCC
TTGTCCTCGCCAAAATGAAAGGGTTTGATGTGTTCAATGCACTGGATCTCATGGAGAACAAAACCTTCCTGGAGAAGCTCAAGTTTGGCA
TAGGGGACGGCAACCTGCAGTATTACCTTTACAATTGGAAATGCCCCAGCATGGGGGCAGAGAAGGTTGGACTGGTGCTACAATAACCAG
TCACCAGTGCGATTCTGGATAAAGCCACTGAAAATTCGAACCAGGAAATGGAACCCCACCACTGTTGGTCCAATTTTCACACACGTGAGA
ATCCCTGGCAAAGGGAGCAGAACTGAACCGGCTTTACCAAACCGCCAGCGAACTTGACAATTGTATTGCGATGGCGTGGGCTGCGTGACG
TCACCTCCGGTCGTGTCTCTGGTCTCCGTGTTTTCCAGTTAATTACATCCTCATGCAGCCGTGATCAAGGGAATGTAACTGCTGAAAACT
AGCTCGTGATTGGCATATAATGGAGTTAACGGGTGAATAATAAAAGTATATATATATATTATATATATATAAATATTTTAAATATCTTTC
ATGTTCCAAATGTACAAGGATGTTTGGTCTTTAATGAAAAGCTGAATCCAGATCATTCCTCAGAATGAGGACCCGAGGACAGTGGCAGAC
AGACGCGTTGGCACAGTTCATGGTTTCCTCCAGAGGAGACATTGGCTTATCATGGGGAAAAAGAGGATCTGGAGAACCTCATCCAGCTCC
CCTTCTGAATCAGCTGGGATGACTGGCTTTGAGAAGGAAGGGAAGATGGAACAGGCTCAGATCTCATGGGATAGCACGTGGAGCTCTTGG
CTGGGGCTGACCCTGGGCAGGGACTTTCCTGCAGGGCCAGACCTGCCTGCATTCTGAGACAAAGCAATGGACGGTCCGCAGAAGCAGACC
TCATTGATTGAGTCCTTTCTTCCATCCCCTTGGCCTGCTCCCTGTAGGAAGTCATCCTGCCAACTGATTTAAAAGGGCTCTTTAGCCAGT
TGTTGCCAACCTTATAGGGATGAGTCCCCTGTGAGATTTTGCTTTTCCACTGCCTGGGATGATGCAGTTTGAAGAGGCCCTTGGACCTCC
TTGTAACATCAGGGACCTTTGGAGACCATTATCAGTGTAAGCCCTGCTTAGCTCATCTTAGAGCAAAGAGCCAGCACCCTGATGTCCCTG
GGGTGGCTAGGCAGGAGTGGCGTGGGGCCAATACCCAGACCCCTTCAGCCACCAGCCCCTGGCCTGTGCCTTCCAACCCATTAGCCATTT
CTTGTTGTGCCCCTTTCCAAGATACAGCCTGCAAGTGGTAGCAAGAAGTGATTAGAGGCAGATCTGGACTTGGCAACAGAAGTGGTTTCC
CATCTCCATTGTCTGAGTCTGATTTTCGCTGATGCTGTTTTGTGGATTTTTGTGGTAGTGATGGTTGTCAGTGCTGCCAGTTTCCCAAAA
CGTAATCAAGCCTCTGGTCACATGGCTGTCGATGTAGGCATTCTGGAGTGGTGTTCAGCCAAGTGACCGGGCAAAATTGGGCTGTGAAAT
TGTACTTCCAGGCTTGGATGTAATTTTTGCTCTAGAGAGAAGCAAGTGGTGGGAAGGAGGTAGCATGACGTGTGGTGTGCGGGTTTCCTT
GCTGCCGTCACCTCTCCGCTCATACAGGAATGAAGCCTTAGCCAGGAGGCCAGGCTCAGCCCTGTGCCACTCACCGAAGCCACTTTCTAC
AGGCCAGCAGGGGCTTGTTGCAGGCTGTGGGTTTTGGTGTGGTTTGTCAGAGGCTAATTCTGCAGAGTTTCCAAAACCAGAAGACATCGT
ATGCTTGGGATGGGGGCCGTGCCACCCGTGGGAATGCTGCCCGCTCTGCAGACTGCTGCTAGAGCCAGCAACTCCACTAAGGTGGATTTT
CATCAGGGGCCTGCAGGGCCCTCCCTTTTCCCATTGTTCCTGCGCTGCAAATTGCAGGCCCCAGCAATCGTGACTGACGTTTGCTCCTTG
ACTCCAAGAAACTGAGACCAAAGAAGCTGCTGTTCTTAGCAAGATGCGCACTGCATTCCACAGGTGGGAGGAGTCGGAGAGGCAGGGGCT
TGCTTTGCAGCCCCACAGACAACAGTTGCACAGTGCCTCAAGCCCCAGAGTGGCTCACCCTGTCCAGACCTTTGAGGATATCAAAGGACA
AAGTGCCCAAGTCTTTCCTACCTTGGGGGAACCTGGAACTTGGAAAGGCTCCCTGTCCTAGTCTTGATCTGTTCTGGGCCAGGTCCCAGC
TTGAGCTGCCTCTGAGATTTGGGCTGTGCGGATCTCTGGAGTGAGCTCTGTTTCGGTTGACCCAGGTCATGGAATGGAAACGGTGAGGCC
CCAGTGGCTGTTCTGGAAGAAACAGATCTCCTGGCAAAGGCCCCAGCATCTCCCTCACTGAAACCAGGTGGCCGGCTCCTCGGACTCTGC
TTTATGTTGCGGTGAGAACTCTGCCCAGGTGTGCAGGGTTTGGCTTGTGGGCTGCTTGCTGCTCATCTGATTTTTGTCCCAGTAGTCCCT
GCGTTCTTCATTCAACCCCTTCTGGGACTTCAGCTCAGAGAGCACCATCCCGGGGGTCAGGGCCTCCCCACAGGAGCCCTGCAGTGTGGT
AGCGCCATGGCTGTCTCAAACCAAGCAAAGGAAGGACCCTGAGGCCTTCACGCTAACCGTCCTCGAGCAACTGCTGTTGGAAGGCCTCCC
TGGGCCTGGCCCCCACCCTCTGCCACCCAGTCCTCCCAGCTGCCATGTTTCAAAGACGACCTTTACCTCCTGCCTTTGGATTGACTCTGC
ATTTGACCACGGACTCCAGTCTGTGTGTAGGGAGAGAGCTGAGTAGGAGGCCTCCACTCCGGATCGAGGCCTGTATAGGGCTCGTTTCCC
CACACATGCCTATTTCTGAAGAGGCTTCTGTCTTATTTGAAGGCCAGCCCACACCCAGCTACTTTAACACCAGGTTTATGGAAAATGTCA
GGCCTTCCCCACAACTCCTGTCTAACTGCTGTCGCCCCCCTACTTGCTGGCTCTCAGAAGCCTAGGGGAGTCCCTGTGGTCCTGAATTCT
TTCCCCAAAGACGACCAGCATTTAACCAACCTAAGGGCCCAAAGGCCTTGGACAACTGCATGGAGCTGCACTCTAGGAGAAGGAGGGGAA
CCAGATGTTAGATCAGGGGAGGGAGCAGGAGTGTCCCTCCCGTCAGTGCCTACCCACCTGTGAGGCAGCCTTCTGATGGCCTGGCCCACC
TTCCCCAGAACCAGGGGAGGCCTGAGGCTTCAGTTTTACTCTGCTGCAAAATGAAGGCGGGCCTGCAAGCCGACTACACCTACGGAGGCT
GTTGAGGACAATTTCATTCCATTAAATTAAAAAATACTGACTGGCTGGCAGGCAGGTGCCATGTCTGGGAACAGGGACGGGGGAGCTTCA
CCTTTTTGTCTTGGCTTTTCTTTGGGCTGTGGGGGGGCATCCATTTCCAGGGTCGGGGAGGAAATACCAAATGCATTGTTGTTCTGCTCA

>28122_28122_1_EZR-NMT1_EZR_chr6_159190357_ENST00000337147_NMT1_chr17_43180318_ENST00000258960_length(amino acids)=637AA_BP=472
MGQRLRCCWIVVFSGIEDTHQKPKMPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKKVS
AQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQR
VMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIR
NISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERQQLETEKKRRETVERE
KEQMMREKEELMLRLQDYEEKTKKAERELSEQIQRALQLEEERKRAQEEAERLEADRMAALRAKEELERQAVDQIKSQEQLAAELAEYTA
KIALLEEARRRKEDEVEEWQHRTPKTAGLRPMETKDIPVVHQLLTRYLKQFHLTPVMSQEEVEHWFYPQENIIDTFVVENANGEVTDFLS
FYTLPSTIMNHPTHKSLKAAYSFYNVHTQTPLLDLMSDALVLAKMKGFDVFNALDLMENKTFLEKLKFGIGDGNLQYYLYNWKCPSMGAE

--------------------------------------------------------------
>28122_28122_2_EZR-NMT1_EZR_chr6_159190357_ENST00000337147_NMT1_chr17_43180318_ENST00000592782_length(transcript)=5353nt_BP=1478nt
GGCGCGGCAGGAGGACGAGGCAGGGCGGGCGGGCGCTCTAAGGGTTCTGCTCTGACTCCAGGTTGGGACAGCGTCTTCGCTGCTGCTGGA
TAGTCGTGTTTTCGGGGATCGAGGATACTCACCAGAAACCGAAAATGCCGAAACCAATCAATGTCCGAGTTACCACCATGGATGCAGAGC
TGGAGTTTGCAATCCAGCCAAATACAACTGGAAAACAGCTTTTTGATCAGGTGGTAAAGACTATCGGCCTCCGGGAAGTGTGGTACTTTG
GCCTCCACTATGTGGATAATAAAGGATTTCCTACCTGGCTGAAGCTGGATAAGAAGGTGTCTGCCCAGGAGGTCAGGAAGGAGAATCCCC
TCCAGTTCAAGTTCCGGGCCAAGTTCTACCCTGAAGATGTGGCTGAGGAGCTCATCCAGGACATCACCCAGAAACTTTTCTTCCTCCAAG
TGAAGGAAGGAATCCTTAGCGATGAGATCTACTGCCCCCCTGAGACTGCCGTGCTCTTGGGGTCCTACGCTGTGCAGGCCAAGTTTGGGG
ACTACAACAAAGAAGTGCACAAGTCTGGGTACCTCAGCTCTGAGCGGCTGATCCCTCAAAGAGTGATGGACCAGCACAAACTTACCAGGG
ACCAGTGGGAGGACCGGATCCAGGTGTGGCATGCGGAACACCGTGGGATGCTCAAAGATAATGCTATGTTGGAATACCTGAAGATTGCTC
AGGACCTGGAAATGTATGGAATCAACTATTTCGAGATAAAAAACAAGAAAGGAACAGACCTTTGGCTTGGAGTTGATGCCCTTGGACTGA
ATATTTATGAGAAAGATGATAAGTTAACCCCAAAGATTGGCTTTCCTTGGAGTGAAATCAGGAACATCTCTTTCAATGACAAAAAGTTTG
TCATTAAACCCATCGACAAGAAGGCACCTGACTTTGTGTTTTATGCCCCACGTCTGAGAATCAACAAGCGGATCCTGCAGCTCTGCATGG
GCAACCATGAGTTGTATATGCGCCGCAGGAAGCCTGACACCATCGAGGTGCAGCAGATGAAGGCCCAGGCCCGGGAGGAGAAGCATCAGA
AGCAGCTGGAGCGGCAACAGCTGGAAACAGAGAAGAAAAGGAGAGAAACCGTGGAGAGAGAGAAAGAGCAGATGATGCGCGAGAAGGAGG
AGTTGATGCTGCGGCTGCAGGACTATGAGGAGAAGACAAAGAAGGCAGAGAGAGAGCTCTCGGAGCAGATTCAGAGGGCCCTGCAGCTGG
AGGAGGAGAGGAAGCGGGCACAGGAGGAGGCCGAGCGCCTAGAGGCTGACCGTATGGCTGCACTGCGGGCTAAGGAGGAGCTGGAGAGAC
AGGCGGTGGATCAGATAAAGAGCCAGGAGCAGCTGGCTGCGGAGCTTGCAGAATACACTGCCAAGATTGCCCTCCTGGAAGAGGCGCGGA
GGCGCAAGGAGGATGAAGTTGAAGAGTGGCAGCACAGGACTCCCAAGACAGCTGGGCTGCGACCAATGGAAACAAAGGACATTCCAGTAG
TGCACCAGCTCCTCACCAGGTACTTGAAGCAATTTCACCTTACGCCCGTCATGAGCCAGGAGGAGGTGGAGCACTGGTTCTACCCCCAGG
AGAATATCATCGACACTTTCGTGGTGGAGAACGCAAACGGAGAGGTGACAGATTTCCTGAGCTTTTATACGCTGCCCTCCACCATCATGA
ACCATCCAACCCACAAGAGTCTCAAAGCTGCTTATTCTTTCTACAACGTTCACACCCAGACCCCTCTTCTAGACCTCATGAGCGACGCCC
TTGTCCTCGCCAAAATGAAAGGGTTTGATGTGTTCAATGCACTGGATCTCATGGAGAACAAAACCTTCCTGGAGAAGCTCAAGTTTGGCA
TAGGGGACGGCAACCTGCAGTATTACCTTTACAATTGGAAATGCCCCAGCATGGGGGCAGAGAAGGTTGGACTGGTGCTACAATAACCAG
TCACCAGTGCGATTCTGGATAAAGCCACTGAAAATTCGAACCAGGAAATGGAACCCCACCACTGTTGGTCCAATTTTCACACACGTGAGA
ATCCCTGGCAAAGGGAGCAGAACTGAACCGGCTTTACCAAACCGCCAGCGAACTTGACAATTGTATTGCGATGGCGTGGGCTGCGTGACG
TCACCTCCGGTCGTGTCTCTGGTCTCCGTGTTTTCCAGTTAATTACATCCTCATGCAGCCGTGATCAAGGGAATGTAACTGCTGAAAACT
AGCTCGTGATTGGCATATAATGGAGTTAACGGGTGAATAATAAAAGTATATATATATATTATATATATATAAATATTTTAAATATCTTTC
ATGTTCCAAATGTACAAGGATGTTTGGTCTTTAATGAAAAGCTGAATCCAGATCATTCCTCAGAATGAGGACCCGAGGACAGTGGCAGAC
AGACGCGTTGGCACAGTTCATGGTTTCCTCCAGAGGAGACATTGGCTTATCATGGGGAAAAAGAGGATCTGGAGAACCTCATCCAGCTCC
CCTTCTGAATCAGCTGGGATGACTGGCTTTGAGAAGGAAGGGAAGATGGAACAGGCTCAGATCTCATGGGATAGCACGTGGAGCTCTTGG
CTGGGGCTGACCCTGGGCAGGGACTTTCCTGCAGGGCCAGACCTGCCTGCATTCTGAGACAAAGCAATGGACGGTCCGCAGAAGCAGACC
TCATTGATTGAGTCCTTTCTTCCATCCCCTTGGCCTGCTCCCTGTAGGAAGTCATCCTGCCAACTGATTTAAAAGGGCTCTTTAGCCAGT
TGTTGCCAACCTTATAGGGATGAGTCCCCTGTGAGATTTTGCTTTTCCACTGCCTGGGATGATGCAGTTTGAAGAGGCCCTTGGACCTCC
TTGTAACATCAGGGACCTTTGGAGACCATTATCAGTGTAAGCCCTGCTTAGCTCATCTTAGAGCAAAGAGCCAGCACCCTGATGTCCCTG
GGGTGGCTAGGCAGGAGTGGCGTGGGGCCAATACCCAGACCCCTTCAGCCACCAGCCCCTGGCCTGTGCCTTCCAACCCATTAGCCATTT
CTTGTTGTGCCCCTTTCCAAGATACAGCCTGCAAGTGGTAGCAAGAAGTGATTAGAGGCAGATCTGGACTTGGCAACAGAAGTGGTTTCC
CATCTCCATTGTCTGAGTCTGATTTTCGCTGATGCTGTTTTGTGGATTTTTGTGGTAGTGATGGTTGTCAGTGCTGCCAGTTTCCCAAAA
CGTAATCAAGCCTCTGGTCACATGGCTGTCGATGTAGGCATTCTGGAGTGGTGTTCAGCCAAGTGACCGGGCAAAATTGGGCTGTGAAAT
TGTACTTCCAGGCTTGGATGTAATTTTTGCTCTAGAGAGAAGCAAGTGGTGGGAAGGAGGTAGCATGACGTGTGGTGTGCGGGTTTCCTT
GCTGCCGTCACCTCTCCGCTCATACAGGAATGAAGCCTTAGCCAGGAGGCCAGGCTCAGCCCTGTGCCACTCACCGAAGCCACTTTCTAC
AGGCCAGCAGGGGCTTGTTGCAGGCTGTGGGTTTTGGTGTGGTTTGTCAGAGGCTAATTCTGCAGAGTTTCCAAAACCAGAAGACATCGT
ATGCTTGGGATGGGGGCCGTGCCACCCGTGGGAATGCTGCCCGCTCTGCAGACTGCTGCTAGAGCCAGCAACTCCACTAAGGTGGATTTT
CATCAGGGGCCTGCAGGGCCCTCCCTTTTCCCATTGTTCCTGCGCTGCAAATTGCAGGCCCCAGCAATCGTGACTGACGTTTGCTCCTTG
ACTCCAAGAAACTGAGACCAAAGAAGCTGCTGTTCTTAGCAAGATGCGCACTGCATTCCACAGGTGGGAGGAGTCGGAGAGGCAGGGGCT
TGCTTTGCAGCCCCACAGACAACAGTTGCACAGTGCCTCAAGCCCCAGAGTGGCTCACCCTGTCCAGACCTTTGAGGATATCAAAGGACA
AAGTGCCCAAGTCTTTCCTACCTTGGGGGAACCTGGAACTTGGAAAGGCTCCCTGTCCTAGTCTTGATCTGTTCTGGGCCAGGTCCCAGC
TTGAGCTGCCTCTGAGATTTGGGCTGTGCGGATCTCTGGAGTGAGCTCTGTTTCGGTTGACCCAGGTCATGGAATGGAAACGGTGAGGCC
CCAGTGGCTGTTCTGGAAGAAACAGATCTCCTGGCAAAGGCCCCAGCATCTCCCTCACTGAAACCAGGTGGCCGGCTCCTCGGACTCTGC
TTTATGTTGCGGTGAGAACTCTGCCCAGGTGTGCAGGGTTTGGCTTGTGGGCTGCTTGCTGCTCATCTGATTTTTGTCCCAGTAGTCCCT
GCGTTCTTCATTCAACCCCTTCTGGGACTTCAGCTCAGAGAGCACCATCCCGGGGGTCAGGGCCTCCCCACAGGAGCCCTGCAGTGTGGT
AGCGCCATGGCTGTCTCAAACCAAGCAAAGGAAGGACCCTGAGGCCTTCACGCTAACCGTCCTCGAGCAACTGCTGTTGGAAGGCCTCCC
TGGGCCTGGCCCCCACCCTCTGCCACCCAGTCCTCCCAGCTGCCATGTTTCAAAGACGACCTTTACCTCCTGCCTTTGGATTGACTCTGC
ATTTGACCACGGACTCCAGTCTGTGTGTAGGGAGAGAGCTGAGTAGGAGGCCTCCACTCCGGATCGAGGCCTGTATAGGGCTCGTTTCCC
CACACATGCCTATTTCTGAAGAGGCTTCTGTCTTATTTGAAGGCCAGCCCACACCCAGCTACTTTAACACCAGGTTTATGGAAAATGTCA
GGCCTTCCCCACAACTCCTGTCTAACTGCTGTCGCCCCCCTACTTGCTGGCTCTCAGAAGCCTAGGGGAGTCCCTGTGGTCCTGAATTCT
TTCCCCAAAGACGACCAGCATTTAACCAACCTAAGGGCCCAAAGGCCTTGGACAACTGCATGGAGCTGCACTCTAGGAGAAGGAGGGGAA
CCAGATGTTAGATCAGGGGAGGGAGCAGGAGTGTCCCTCCCGTCAGTGCCTACCCACCTGTGAGGCAGCCTTCTGATGGCCTGGCCCACC
TTCCCCAGAACCAGGGGAGGCCTGAGGCTTCAGTTTTACTCTGCTGCAAAATGAAGGCGGGCCTGCAAGCCGACTACACCTACGGAGGCT
GTTGAGGACAATTTCATTCCATTAAATTAAAAAATACTGACTGGCTGGCAGGCAGGTGCCATGTCTGGGAACAGGGACGGGGGAGCTTCA
CCTTTTTGTCTTGGCTTTTCTTTGGGCTGTGGGGGGGCATCCATTTCCAGGGTCGGGGAGGAAATACCAAATGCATTGTTGTTCTGCTCA

>28122_28122_2_EZR-NMT1_EZR_chr6_159190357_ENST00000337147_NMT1_chr17_43180318_ENST00000592782_length(amino acids)=637AA_BP=472
MGQRLRCCWIVVFSGIEDTHQKPKMPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKKVS
AQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQR
VMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIR
NISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERQQLETEKKRRETVERE
KEQMMREKEELMLRLQDYEEKTKKAERELSEQIQRALQLEEERKRAQEEAERLEADRMAALRAKEELERQAVDQIKSQEQLAAELAEYTA
KIALLEEARRRKEDEVEEWQHRTPKTAGLRPMETKDIPVVHQLLTRYLKQFHLTPVMSQEEVEHWFYPQENIIDTFVVENANGEVTDFLS
FYTLPSTIMNHPTHKSLKAAYSFYNVHTQTPLLDLMSDALVLAKMKGFDVFNALDLMENKTFLEKLKFGIGDGNLQYYLYNWKCPSMGAE

--------------------------------------------------------------
>28122_28122_3_EZR-NMT1_EZR_chr6_159190357_ENST00000392177_NMT1_chr17_43180318_ENST00000258960_length(transcript)=5256nt_BP=1388nt
GTGTCGGGCGCGGCAGGAGGACGAGGCAGGGCGGGCGGGCGCTCTAAGGGTTCTGCTCTGACTCCAGGTTGGGACAGCGTCTTCGCTGCT
GCTGGATAGTCGTGTTTTCGGGGATCGAGGATACTCACCAGAAACCGAAAATGCCGAAACCAATCAATGTCCGAGTTACCACCATGGATG
CAGAGCTGGAGTTTGCAATCCAGCCAAATACAACTGGAAAACAGCTTTTTGATCAGGTGTCTGCCCAGGAGGTCAGGAAGGAGAATCCCC
TCCAGTTCAAGTTCCGGGCCAAGTTCTACCCTGAAGATGTGGCTGAGGAGCTCATCCAGGACATCACCCAGAAACTTTTCTTCCTCCAAG
TGAAGGAAGGAATCCTTAGCGATGAGATCTACTGCCCCCCTGAGACTGCCGTGCTCTTGGGGTCCTACGCTGTGCAGGCCAAGTTTGGGG
ACTACAACAAAGAAGTGCACAAGTCTGGGTACCTCAGCTCTGAGCGGCTGATCCCTCAAAGAGTGATGGACCAGCACAAACTTACCAGGG
ACCAGTGGGAGGACCGGATCCAGGTGTGGCATGCGGAACACCGTGGGATGCTCAAAGATAATGCTATGTTGGAATACCTGAAGATTGCTC
AGGACCTGGAAATGTATGGAATCAACTATTTCGAGATAAAAAACAAGAAAGGAACAGACCTTTGGCTTGGAGTTGATGCCCTTGGACTGA
ATATTTATGAGAAAGATGATAAGTTAACCCCAAAGATTGGCTTTCCTTGGAGTGAAATCAGGAACATCTCTTTCAATGACAAAAAGTTTG
TCATTAAACCCATCGACAAGAAGGCACCTGACTTTGTGTTTTATGCCCCACGTCTGAGAATCAACAAGCGGATCCTGCAGCTCTGCATGG
GCAACCATGAGTTGTATATGCGCCGCAGGAAGCCTGACACCATCGAGGTGCAGCAGATGAAGGCCCAGGCCCGGGAGGAGAAGCATCAGA
AGCAGCTGGAGCGGCAACAGCTGGAAACAGAGAAGAAAAGGAGAGAAACCGTGGAGAGAGAGAAAGAGCAGATGATGCGCGAGAAGGAGG
AGTTGATGCTGCGGCTGCAGGACTATGAGGAGAAGACAAAGAAGGCAGAGAGAGAGCTCTCGGAGCAGATTCAGAGGGCCCTGCAGCTGG
AGGAGGAGAGGAAGCGGGCACAGGAGGAGGCCGAGCGCCTAGAGGCTGACCGTATGGCTGCACTGCGGGCTAAGGAGGAGCTGGAGAGAC
AGGCGGTGGATCAGATAAAGAGCCAGGAGCAGCTGGCTGCGGAGCTTGCAGAATACACTGCCAAGATTGCCCTCCTGGAAGAGGCGCGGA
GGCGCAAGGAGGATGAAGTTGAAGAGTGGCAGCACAGGACTCCCAAGACAGCTGGGCTGCGACCAATGGAAACAAAGGACATTCCAGTAG
TGCACCAGCTCCTCACCAGGTACTTGAAGCAATTTCACCTTACGCCCGTCATGAGCCAGGAGGAGGTGGAGCACTGGTTCTACCCCCAGG
AGAATATCATCGACACTTTCGTGGTGGAGAACGCAAACGGAGAGGTGACAGATTTCCTGAGCTTTTATACGCTGCCCTCCACCATCATGA
ACCATCCAACCCACAAGAGTCTCAAAGCTGCTTATTCTTTCTACAACGTTCACACCCAGACCCCTCTTCTAGACCTCATGAGCGACGCCC
TTGTCCTCGCCAAAATGAAAGGGTTTGATGTGTTCAATGCACTGGATCTCATGGAGAACAAAACCTTCCTGGAGAAGCTCAAGTTTGGCA
TAGGGGACGGCAACCTGCAGTATTACCTTTACAATTGGAAATGCCCCAGCATGGGGGCAGAGAAGGTTGGACTGGTGCTACAATAACCAG
TCACCAGTGCGATTCTGGATAAAGCCACTGAAAATTCGAACCAGGAAATGGAACCCCACCACTGTTGGTCCAATTTTCACACACGTGAGA
ATCCCTGGCAAAGGGAGCAGAACTGAACCGGCTTTACCAAACCGCCAGCGAACTTGACAATTGTATTGCGATGGCGTGGGCTGCGTGACG
TCACCTCCGGTCGTGTCTCTGGTCTCCGTGTTTTCCAGTTAATTACATCCTCATGCAGCCGTGATCAAGGGAATGTAACTGCTGAAAACT
AGCTCGTGATTGGCATATAATGGAGTTAACGGGTGAATAATAAAAGTATATATATATATTATATATATATAAATATTTTAAATATCTTTC
ATGTTCCAAATGTACAAGGATGTTTGGTCTTTAATGAAAAGCTGAATCCAGATCATTCCTCAGAATGAGGACCCGAGGACAGTGGCAGAC
AGACGCGTTGGCACAGTTCATGGTTTCCTCCAGAGGAGACATTGGCTTATCATGGGGAAAAAGAGGATCTGGAGAACCTCATCCAGCTCC
CCTTCTGAATCAGCTGGGATGACTGGCTTTGAGAAGGAAGGGAAGATGGAACAGGCTCAGATCTCATGGGATAGCACGTGGAGCTCTTGG
CTGGGGCTGACCCTGGGCAGGGACTTTCCTGCAGGGCCAGACCTGCCTGCATTCTGAGACAAAGCAATGGACGGTCCGCAGAAGCAGACC
TCATTGATTGAGTCCTTTCTTCCATCCCCTTGGCCTGCTCCCTGTAGGAAGTCATCCTGCCAACTGATTTAAAAGGGCTCTTTAGCCAGT
TGTTGCCAACCTTATAGGGATGAGTCCCCTGTGAGATTTTGCTTTTCCACTGCCTGGGATGATGCAGTTTGAAGAGGCCCTTGGACCTCC
TTGTAACATCAGGGACCTTTGGAGACCATTATCAGTGTAAGCCCTGCTTAGCTCATCTTAGAGCAAAGAGCCAGCACCCTGATGTCCCTG
GGGTGGCTAGGCAGGAGTGGCGTGGGGCCAATACCCAGACCCCTTCAGCCACCAGCCCCTGGCCTGTGCCTTCCAACCCATTAGCCATTT
CTTGTTGTGCCCCTTTCCAAGATACAGCCTGCAAGTGGTAGCAAGAAGTGATTAGAGGCAGATCTGGACTTGGCAACAGAAGTGGTTTCC
CATCTCCATTGTCTGAGTCTGATTTTCGCTGATGCTGTTTTGTGGATTTTTGTGGTAGTGATGGTTGTCAGTGCTGCCAGTTTCCCAAAA
CGTAATCAAGCCTCTGGTCACATGGCTGTCGATGTAGGCATTCTGGAGTGGTGTTCAGCCAAGTGACCGGGCAAAATTGGGCTGTGAAAT
TGTACTTCCAGGCTTGGATGTAATTTTTGCTCTAGAGAGAAGCAAGTGGTGGGAAGGAGGTAGCATGACGTGTGGTGTGCGGGTTTCCTT
GCTGCCGTCACCTCTCCGCTCATACAGGAATGAAGCCTTAGCCAGGAGGCCAGGCTCAGCCCTGTGCCACTCACCGAAGCCACTTTCTAC
AGGCCAGCAGGGGCTTGTTGCAGGCTGTGGGTTTTGGTGTGGTTTGTCAGAGGCTAATTCTGCAGAGTTTCCAAAACCAGAAGACATCGT
ATGCTTGGGATGGGGGCCGTGCCACCCGTGGGAATGCTGCCCGCTCTGCAGACTGCTGCTAGAGCCAGCAACTCCACTAAGGTGGATTTT
CATCAGGGGCCTGCAGGGCCCTCCCTTTTCCCATTGTTCCTGCGCTGCAAATTGCAGGCCCCAGCAATCGTGACTGACGTTTGCTCCTTG
ACTCCAAGAAACTGAGACCAAAGAAGCTGCTGTTCTTAGCAAGATGCGCACTGCATTCCACAGGTGGGAGGAGTCGGAGAGGCAGGGGCT
TGCTTTGCAGCCCCACAGACAACAGTTGCACAGTGCCTCAAGCCCCAGAGTGGCTCACCCTGTCCAGACCTTTGAGGATATCAAAGGACA
AAGTGCCCAAGTCTTTCCTACCTTGGGGGAACCTGGAACTTGGAAAGGCTCCCTGTCCTAGTCTTGATCTGTTCTGGGCCAGGTCCCAGC
TTGAGCTGCCTCTGAGATTTGGGCTGTGCGGATCTCTGGAGTGAGCTCTGTTTCGGTTGACCCAGGTCATGGAATGGAAACGGTGAGGCC
CCAGTGGCTGTTCTGGAAGAAACAGATCTCCTGGCAAAGGCCCCAGCATCTCCCTCACTGAAACCAGGTGGCCGGCTCCTCGGACTCTGC
TTTATGTTGCGGTGAGAACTCTGCCCAGGTGTGCAGGGTTTGGCTTGTGGGCTGCTTGCTGCTCATCTGATTTTTGTCCCAGTAGTCCCT
GCGTTCTTCATTCAACCCCTTCTGGGACTTCAGCTCAGAGAGCACCATCCCGGGGGTCAGGGCCTCCCCACAGGAGCCCTGCAGTGTGGT
AGCGCCATGGCTGTCTCAAACCAAGCAAAGGAAGGACCCTGAGGCCTTCACGCTAACCGTCCTCGAGCAACTGCTGTTGGAAGGCCTCCC
TGGGCCTGGCCCCCACCCTCTGCCACCCAGTCCTCCCAGCTGCCATGTTTCAAAGACGACCTTTACCTCCTGCCTTTGGATTGACTCTGC
ATTTGACCACGGACTCCAGTCTGTGTGTAGGGAGAGAGCTGAGTAGGAGGCCTCCACTCCGGATCGAGGCCTGTATAGGGCTCGTTTCCC
CACACATGCCTATTTCTGAAGAGGCTTCTGTCTTATTTGAAGGCCAGCCCACACCCAGCTACTTTAACACCAGGTTTATGGAAAATGTCA
GGCCTTCCCCACAACTCCTGTCTAACTGCTGTCGCCCCCCTACTTGCTGGCTCTCAGAAGCCTAGGGGAGTCCCTGTGGTCCTGAATTCT
TTCCCCAAAGACGACCAGCATTTAACCAACCTAAGGGCCCAAAGGCCTTGGACAACTGCATGGAGCTGCACTCTAGGAGAAGGAGGGGAA
CCAGATGTTAGATCAGGGGAGGGAGCAGGAGTGTCCCTCCCGTCAGTGCCTACCCACCTGTGAGGCAGCCTTCTGATGGCCTGGCCCACC
TTCCCCAGAACCAGGGGAGGCCTGAGGCTTCAGTTTTACTCTGCTGCAAAATGAAGGCGGGCCTGCAAGCCGACTACACCTACGGAGGCT
GTTGAGGACAATTTCATTCCATTAAATTAAAAAATACTGACTGGCTGGCAGGCAGGTGCCATGTCTGGGAACAGGGACGGGGGAGCTTCA
CCTTTTTGTCTTGGCTTTTCTTTGGGCTGTGGGGGGGCATCCATTTCCAGGGTCGGGGAGGAAATACCAAATGCATTGTTGTTCTGCTCA

>28122_28122_3_EZR-NMT1_EZR_chr6_159190357_ENST00000392177_NMT1_chr17_43180318_ENST00000258960_length(amino acids)=605AA_BP=440
MGQRLRCCWIVVFSGIEDTHQKPKMPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDIT
QKLFFLQVKEGILSDEIYCPPETAVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAM
LEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINK
RILQLCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKTKKAERELSEQ
IQRALQLEEERKRAQEEAERLEADRMAALRAKEELERQAVDQIKSQEQLAAELAEYTAKIALLEEARRRKEDEVEEWQHRTPKTAGLRPM
ETKDIPVVHQLLTRYLKQFHLTPVMSQEEVEHWFYPQENIIDTFVVENANGEVTDFLSFYTLPSTIMNHPTHKSLKAAYSFYNVHTQTPL

--------------------------------------------------------------
>28122_28122_4_EZR-NMT1_EZR_chr6_159190357_ENST00000392177_NMT1_chr17_43180318_ENST00000592782_length(transcript)=5263nt_BP=1388nt
GTGTCGGGCGCGGCAGGAGGACGAGGCAGGGCGGGCGGGCGCTCTAAGGGTTCTGCTCTGACTCCAGGTTGGGACAGCGTCTTCGCTGCT
GCTGGATAGTCGTGTTTTCGGGGATCGAGGATACTCACCAGAAACCGAAAATGCCGAAACCAATCAATGTCCGAGTTACCACCATGGATG
CAGAGCTGGAGTTTGCAATCCAGCCAAATACAACTGGAAAACAGCTTTTTGATCAGGTGTCTGCCCAGGAGGTCAGGAAGGAGAATCCCC
TCCAGTTCAAGTTCCGGGCCAAGTTCTACCCTGAAGATGTGGCTGAGGAGCTCATCCAGGACATCACCCAGAAACTTTTCTTCCTCCAAG
TGAAGGAAGGAATCCTTAGCGATGAGATCTACTGCCCCCCTGAGACTGCCGTGCTCTTGGGGTCCTACGCTGTGCAGGCCAAGTTTGGGG
ACTACAACAAAGAAGTGCACAAGTCTGGGTACCTCAGCTCTGAGCGGCTGATCCCTCAAAGAGTGATGGACCAGCACAAACTTACCAGGG
ACCAGTGGGAGGACCGGATCCAGGTGTGGCATGCGGAACACCGTGGGATGCTCAAAGATAATGCTATGTTGGAATACCTGAAGATTGCTC
AGGACCTGGAAATGTATGGAATCAACTATTTCGAGATAAAAAACAAGAAAGGAACAGACCTTTGGCTTGGAGTTGATGCCCTTGGACTGA
ATATTTATGAGAAAGATGATAAGTTAACCCCAAAGATTGGCTTTCCTTGGAGTGAAATCAGGAACATCTCTTTCAATGACAAAAAGTTTG
TCATTAAACCCATCGACAAGAAGGCACCTGACTTTGTGTTTTATGCCCCACGTCTGAGAATCAACAAGCGGATCCTGCAGCTCTGCATGG
GCAACCATGAGTTGTATATGCGCCGCAGGAAGCCTGACACCATCGAGGTGCAGCAGATGAAGGCCCAGGCCCGGGAGGAGAAGCATCAGA
AGCAGCTGGAGCGGCAACAGCTGGAAACAGAGAAGAAAAGGAGAGAAACCGTGGAGAGAGAGAAAGAGCAGATGATGCGCGAGAAGGAGG
AGTTGATGCTGCGGCTGCAGGACTATGAGGAGAAGACAAAGAAGGCAGAGAGAGAGCTCTCGGAGCAGATTCAGAGGGCCCTGCAGCTGG
AGGAGGAGAGGAAGCGGGCACAGGAGGAGGCCGAGCGCCTAGAGGCTGACCGTATGGCTGCACTGCGGGCTAAGGAGGAGCTGGAGAGAC
AGGCGGTGGATCAGATAAAGAGCCAGGAGCAGCTGGCTGCGGAGCTTGCAGAATACACTGCCAAGATTGCCCTCCTGGAAGAGGCGCGGA
GGCGCAAGGAGGATGAAGTTGAAGAGTGGCAGCACAGGACTCCCAAGACAGCTGGGCTGCGACCAATGGAAACAAAGGACATTCCAGTAG
TGCACCAGCTCCTCACCAGGTACTTGAAGCAATTTCACCTTACGCCCGTCATGAGCCAGGAGGAGGTGGAGCACTGGTTCTACCCCCAGG
AGAATATCATCGACACTTTCGTGGTGGAGAACGCAAACGGAGAGGTGACAGATTTCCTGAGCTTTTATACGCTGCCCTCCACCATCATGA
ACCATCCAACCCACAAGAGTCTCAAAGCTGCTTATTCTTTCTACAACGTTCACACCCAGACCCCTCTTCTAGACCTCATGAGCGACGCCC
TTGTCCTCGCCAAAATGAAAGGGTTTGATGTGTTCAATGCACTGGATCTCATGGAGAACAAAACCTTCCTGGAGAAGCTCAAGTTTGGCA
TAGGGGACGGCAACCTGCAGTATTACCTTTACAATTGGAAATGCCCCAGCATGGGGGCAGAGAAGGTTGGACTGGTGCTACAATAACCAG
TCACCAGTGCGATTCTGGATAAAGCCACTGAAAATTCGAACCAGGAAATGGAACCCCACCACTGTTGGTCCAATTTTCACACACGTGAGA
ATCCCTGGCAAAGGGAGCAGAACTGAACCGGCTTTACCAAACCGCCAGCGAACTTGACAATTGTATTGCGATGGCGTGGGCTGCGTGACG
TCACCTCCGGTCGTGTCTCTGGTCTCCGTGTTTTCCAGTTAATTACATCCTCATGCAGCCGTGATCAAGGGAATGTAACTGCTGAAAACT
AGCTCGTGATTGGCATATAATGGAGTTAACGGGTGAATAATAAAAGTATATATATATATTATATATATATAAATATTTTAAATATCTTTC
ATGTTCCAAATGTACAAGGATGTTTGGTCTTTAATGAAAAGCTGAATCCAGATCATTCCTCAGAATGAGGACCCGAGGACAGTGGCAGAC
AGACGCGTTGGCACAGTTCATGGTTTCCTCCAGAGGAGACATTGGCTTATCATGGGGAAAAAGAGGATCTGGAGAACCTCATCCAGCTCC
CCTTCTGAATCAGCTGGGATGACTGGCTTTGAGAAGGAAGGGAAGATGGAACAGGCTCAGATCTCATGGGATAGCACGTGGAGCTCTTGG
CTGGGGCTGACCCTGGGCAGGGACTTTCCTGCAGGGCCAGACCTGCCTGCATTCTGAGACAAAGCAATGGACGGTCCGCAGAAGCAGACC
TCATTGATTGAGTCCTTTCTTCCATCCCCTTGGCCTGCTCCCTGTAGGAAGTCATCCTGCCAACTGATTTAAAAGGGCTCTTTAGCCAGT
TGTTGCCAACCTTATAGGGATGAGTCCCCTGTGAGATTTTGCTTTTCCACTGCCTGGGATGATGCAGTTTGAAGAGGCCCTTGGACCTCC
TTGTAACATCAGGGACCTTTGGAGACCATTATCAGTGTAAGCCCTGCTTAGCTCATCTTAGAGCAAAGAGCCAGCACCCTGATGTCCCTG
GGGTGGCTAGGCAGGAGTGGCGTGGGGCCAATACCCAGACCCCTTCAGCCACCAGCCCCTGGCCTGTGCCTTCCAACCCATTAGCCATTT
CTTGTTGTGCCCCTTTCCAAGATACAGCCTGCAAGTGGTAGCAAGAAGTGATTAGAGGCAGATCTGGACTTGGCAACAGAAGTGGTTTCC
CATCTCCATTGTCTGAGTCTGATTTTCGCTGATGCTGTTTTGTGGATTTTTGTGGTAGTGATGGTTGTCAGTGCTGCCAGTTTCCCAAAA
CGTAATCAAGCCTCTGGTCACATGGCTGTCGATGTAGGCATTCTGGAGTGGTGTTCAGCCAAGTGACCGGGCAAAATTGGGCTGTGAAAT
TGTACTTCCAGGCTTGGATGTAATTTTTGCTCTAGAGAGAAGCAAGTGGTGGGAAGGAGGTAGCATGACGTGTGGTGTGCGGGTTTCCTT
GCTGCCGTCACCTCTCCGCTCATACAGGAATGAAGCCTTAGCCAGGAGGCCAGGCTCAGCCCTGTGCCACTCACCGAAGCCACTTTCTAC
AGGCCAGCAGGGGCTTGTTGCAGGCTGTGGGTTTTGGTGTGGTTTGTCAGAGGCTAATTCTGCAGAGTTTCCAAAACCAGAAGACATCGT
ATGCTTGGGATGGGGGCCGTGCCACCCGTGGGAATGCTGCCCGCTCTGCAGACTGCTGCTAGAGCCAGCAACTCCACTAAGGTGGATTTT
CATCAGGGGCCTGCAGGGCCCTCCCTTTTCCCATTGTTCCTGCGCTGCAAATTGCAGGCCCCAGCAATCGTGACTGACGTTTGCTCCTTG
ACTCCAAGAAACTGAGACCAAAGAAGCTGCTGTTCTTAGCAAGATGCGCACTGCATTCCACAGGTGGGAGGAGTCGGAGAGGCAGGGGCT
TGCTTTGCAGCCCCACAGACAACAGTTGCACAGTGCCTCAAGCCCCAGAGTGGCTCACCCTGTCCAGACCTTTGAGGATATCAAAGGACA
AAGTGCCCAAGTCTTTCCTACCTTGGGGGAACCTGGAACTTGGAAAGGCTCCCTGTCCTAGTCTTGATCTGTTCTGGGCCAGGTCCCAGC
TTGAGCTGCCTCTGAGATTTGGGCTGTGCGGATCTCTGGAGTGAGCTCTGTTTCGGTTGACCCAGGTCATGGAATGGAAACGGTGAGGCC
CCAGTGGCTGTTCTGGAAGAAACAGATCTCCTGGCAAAGGCCCCAGCATCTCCCTCACTGAAACCAGGTGGCCGGCTCCTCGGACTCTGC
TTTATGTTGCGGTGAGAACTCTGCCCAGGTGTGCAGGGTTTGGCTTGTGGGCTGCTTGCTGCTCATCTGATTTTTGTCCCAGTAGTCCCT
GCGTTCTTCATTCAACCCCTTCTGGGACTTCAGCTCAGAGAGCACCATCCCGGGGGTCAGGGCCTCCCCACAGGAGCCCTGCAGTGTGGT
AGCGCCATGGCTGTCTCAAACCAAGCAAAGGAAGGACCCTGAGGCCTTCACGCTAACCGTCCTCGAGCAACTGCTGTTGGAAGGCCTCCC
TGGGCCTGGCCCCCACCCTCTGCCACCCAGTCCTCCCAGCTGCCATGTTTCAAAGACGACCTTTACCTCCTGCCTTTGGATTGACTCTGC
ATTTGACCACGGACTCCAGTCTGTGTGTAGGGAGAGAGCTGAGTAGGAGGCCTCCACTCCGGATCGAGGCCTGTATAGGGCTCGTTTCCC
CACACATGCCTATTTCTGAAGAGGCTTCTGTCTTATTTGAAGGCCAGCCCACACCCAGCTACTTTAACACCAGGTTTATGGAAAATGTCA
GGCCTTCCCCACAACTCCTGTCTAACTGCTGTCGCCCCCCTACTTGCTGGCTCTCAGAAGCCTAGGGGAGTCCCTGTGGTCCTGAATTCT
TTCCCCAAAGACGACCAGCATTTAACCAACCTAAGGGCCCAAAGGCCTTGGACAACTGCATGGAGCTGCACTCTAGGAGAAGGAGGGGAA
CCAGATGTTAGATCAGGGGAGGGAGCAGGAGTGTCCCTCCCGTCAGTGCCTACCCACCTGTGAGGCAGCCTTCTGATGGCCTGGCCCACC
TTCCCCAGAACCAGGGGAGGCCTGAGGCTTCAGTTTTACTCTGCTGCAAAATGAAGGCGGGCCTGCAAGCCGACTACACCTACGGAGGCT
GTTGAGGACAATTTCATTCCATTAAATTAAAAAATACTGACTGGCTGGCAGGCAGGTGCCATGTCTGGGAACAGGGACGGGGGAGCTTCA
CCTTTTTGTCTTGGCTTTTCTTTGGGCTGTGGGGGGGCATCCATTTCCAGGGTCGGGGAGGAAATACCAAATGCATTGTTGTTCTGCTCA

>28122_28122_4_EZR-NMT1_EZR_chr6_159190357_ENST00000392177_NMT1_chr17_43180318_ENST00000592782_length(amino acids)=605AA_BP=440
MGQRLRCCWIVVFSGIEDTHQKPKMPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDIT
QKLFFLQVKEGILSDEIYCPPETAVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAM
LEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINK
RILQLCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKTKKAERELSEQ
IQRALQLEEERKRAQEEAERLEADRMAALRAKEELERQAVDQIKSQEQLAAELAEYTAKIALLEEARRRKEDEVEEWQHRTPKTAGLRPM
ETKDIPVVHQLLTRYLKQFHLTPVMSQEEVEHWFYPQENIIDTFVVENANGEVTDFLSFYTLPSTIMNHPTHKSLKAAYSFYNVHTQTPL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for EZR-NMT1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneEZRchr6:159190357chr17:43180318ENST00000337147-1113244_586448.0587.0SCYL3
HgeneEZRchr6:159190357chr17:43180318ENST00000367075-1214244_586448.0587.0SCYL3


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for EZR-NMT1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for EZR-NMT1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource