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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ABCC4-PCCA (FusionGDB2 ID:282)

Fusion Gene Summary for ABCC4-PCCA

check button Fusion gene summary
Fusion gene informationFusion gene name: ABCC4-PCCA
Fusion gene ID: 282
HgeneTgene
Gene symbol

ABCC4

PCCA

Gene ID

10257

5095

Gene nameATP binding cassette subfamily C member 4propionyl-CoA carboxylase subunit alpha
SynonymsMOAT-B|MOATB|MRP4-
Cytomap

13q32.1

13q32.3

Type of geneprotein-codingprotein-coding
Descriptionmultidrug resistance-associated protein 4MRP/cMOAT-related ABC transporterbA464I2.1 (ATP-binding cassette, sub-family C (CFTR/MRP), member 4)canalicular multispecific organic anion transporter (ABC superfamily)multi-specific organic anion transporter propionyl-CoA carboxylase alpha chain, mitochondrialPCCase alpha subunitpccA complementation grouppropanoyl-CoA:carbon dioxide ligase alpha subunitpropionyl CoA carboxylase, alpha polypeptidepropionyl Coenzyme A carboxylase, alpha polypeptidepropion
Modification date2020031320200313
UniProtAcc

O15439

.
Ensembl transtripts involved in fusion geneENST00000538287, ENST00000376887, 
ENST00000412704, ENST00000431522, 
ENST00000536256, ENST00000474158, 
ENST00000376279, ENST00000376285, 
ENST00000376286, ENST00000485946, 
Fusion gene scores* DoF score23 X 21 X 11=531321 X 22 X 6=2772
# samples 2523
** MAII scorelog2(25/5313*10)=-4.40952671281098
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(23/2772*10)=-3.59122149119284
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ABCC4 [Title/Abstract] AND PCCA [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointABCC4(95858786)-PCCA(100755137), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneABCC4

GO:0032310

prostaglandin secretion

25173977


check buttonFusion gene breakpoints across ABCC4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PCCA (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A1L0-01AABCC4chr13

95858786

-PCCAchr13

100755137

+


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Fusion Gene ORF analysis for ABCC4-PCCA

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000538287ENST00000376279ABCC4chr13

95858786

-PCCAchr13

100755137

+
3UTR-intronENST00000538287ENST00000376285ABCC4chr13

95858786

-PCCAchr13

100755137

+
3UTR-intronENST00000538287ENST00000376286ABCC4chr13

95858786

-PCCAchr13

100755137

+
3UTR-intronENST00000538287ENST00000485946ABCC4chr13

95858786

-PCCAchr13

100755137

+
5CDS-intronENST00000376887ENST00000376285ABCC4chr13

95858786

-PCCAchr13

100755137

+
5CDS-intronENST00000376887ENST00000376286ABCC4chr13

95858786

-PCCAchr13

100755137

+
5CDS-intronENST00000376887ENST00000485946ABCC4chr13

95858786

-PCCAchr13

100755137

+
5CDS-intronENST00000412704ENST00000376285ABCC4chr13

95858786

-PCCAchr13

100755137

+
5CDS-intronENST00000412704ENST00000376286ABCC4chr13

95858786

-PCCAchr13

100755137

+
5CDS-intronENST00000412704ENST00000485946ABCC4chr13

95858786

-PCCAchr13

100755137

+
5CDS-intronENST00000431522ENST00000376285ABCC4chr13

95858786

-PCCAchr13

100755137

+
5CDS-intronENST00000431522ENST00000376286ABCC4chr13

95858786

-PCCAchr13

100755137

+
5CDS-intronENST00000431522ENST00000485946ABCC4chr13

95858786

-PCCAchr13

100755137

+
5CDS-intronENST00000536256ENST00000376285ABCC4chr13

95858786

-PCCAchr13

100755137

+
5CDS-intronENST00000536256ENST00000376286ABCC4chr13

95858786

-PCCAchr13

100755137

+
5CDS-intronENST00000536256ENST00000485946ABCC4chr13

95858786

-PCCAchr13

100755137

+
In-frameENST00000376887ENST00000376279ABCC4chr13

95858786

-PCCAchr13

100755137

+
In-frameENST00000412704ENST00000376279ABCC4chr13

95858786

-PCCAchr13

100755137

+
In-frameENST00000431522ENST00000376279ABCC4chr13

95858786

-PCCAchr13

100755137

+
In-frameENST00000536256ENST00000376279ABCC4chr13

95858786

-PCCAchr13

100755137

+
intron-3CDSENST00000474158ENST00000376279ABCC4chr13

95858786

-PCCAchr13

100755137

+
intron-intronENST00000474158ENST00000376285ABCC4chr13

95858786

-PCCAchr13

100755137

+
intron-intronENST00000474158ENST00000376286ABCC4chr13

95858786

-PCCAchr13

100755137

+
intron-intronENST00000474158ENST00000485946ABCC4chr13

95858786

-PCCAchr13

100755137

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000412704ABCC4chr1395858786-ENST00000376279PCCAchr13100755137+3487128011932201033
ENST00000376887ABCC4chr1395858786-ENST00000376279PCCAchr13100755137+3483127611532161033
ENST00000536256ABCC4chr1395858786-ENST00000376279PCCAchr13100755137+326210551192995958
ENST00000431522ABCC4chr1395858786-ENST00000376279PCCAchr13100755137+3487128011932201033

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000412704ENST00000376279ABCC4chr1395858786-PCCAchr13100755137+0.0004367180.9995633
ENST00000376887ENST00000376279ABCC4chr1395858786-PCCAchr13100755137+0.0004354660.99956447
ENST00000536256ENST00000376279ABCC4chr1395858786-PCCAchr13100755137+0.0003897890.99961025
ENST00000431522ENST00000376279ABCC4chr1395858786-PCCAchr13100755137+0.0004367180.9995633

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Fusion Genomic Features for ABCC4-PCCA


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ABCC4chr1395858785-PCCAchr13100755136+0.0008915420.9991085
ABCC4chr1395858785-PCCAchr13100755136+0.0008915420.9991085

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ABCC4-PCCA


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr13:95858786/chr13:100755137)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ABCC4

O15439

.
FUNCTION: ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12883481, PubMed:12523936, PubMed:12835412, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12883481, PubMed:12523936, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:18300232, PubMed:17344354). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685). {ECO:0000269|PubMed:11106685, ECO:0000269|PubMed:11856762, ECO:0000269|PubMed:12105214, ECO:0000269|PubMed:12523936, ECO:0000269|PubMed:12835412, ECO:0000269|PubMed:12883481, ECO:0000269|PubMed:15364914, ECO:0000269|PubMed:15454390, ECO:0000269|PubMed:16282361, ECO:0000269|PubMed:17344354, ECO:0000269|PubMed:17959747, ECO:0000269|PubMed:18300232, ECO:0000269|PubMed:26721430}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneABCC4chr13:95858786chr13:100755137ENST00000376887-83192_3773871326.0DomainABC transmembrane type-1 1
HgeneABCC4chr13:95858786chr13:100755137ENST00000412704-83092_3773871279.0DomainABC transmembrane type-1 1
HgeneABCC4chr13:95858786chr13:100755137ENST00000431522-82192_377387860.0DomainABC transmembrane type-1 1
HgeneABCC4chr13:95858786chr13:100755137ENST00000376887-831136_1563871326.0TransmembraneHelical
HgeneABCC4chr13:95858786chr13:100755137ENST00000376887-831207_2273871326.0TransmembraneHelical
HgeneABCC4chr13:95858786chr13:100755137ENST00000376887-831228_2483871326.0TransmembraneHelical
HgeneABCC4chr13:95858786chr13:100755137ENST00000376887-831328_3483871326.0TransmembraneHelical
HgeneABCC4chr13:95858786chr13:100755137ENST00000376887-831351_3713871326.0TransmembraneHelical
HgeneABCC4chr13:95858786chr13:100755137ENST00000376887-83193_1133871326.0TransmembraneHelical
HgeneABCC4chr13:95858786chr13:100755137ENST00000412704-830136_1563871279.0TransmembraneHelical
HgeneABCC4chr13:95858786chr13:100755137ENST00000412704-830207_2273871279.0TransmembraneHelical
HgeneABCC4chr13:95858786chr13:100755137ENST00000412704-830228_2483871279.0TransmembraneHelical
HgeneABCC4chr13:95858786chr13:100755137ENST00000412704-830328_3483871279.0TransmembraneHelical
HgeneABCC4chr13:95858786chr13:100755137ENST00000412704-830351_3713871279.0TransmembraneHelical
HgeneABCC4chr13:95858786chr13:100755137ENST00000412704-83093_1133871279.0TransmembraneHelical
HgeneABCC4chr13:95858786chr13:100755137ENST00000431522-821136_156387860.0TransmembraneHelical
HgeneABCC4chr13:95858786chr13:100755137ENST00000431522-821207_227387860.0TransmembraneHelical
HgeneABCC4chr13:95858786chr13:100755137ENST00000431522-821228_248387860.0TransmembraneHelical
HgeneABCC4chr13:95858786chr13:100755137ENST00000431522-821328_348387860.0TransmembraneHelical
HgeneABCC4chr13:95858786chr13:100755137ENST00000431522-821351_371387860.0TransmembraneHelical
HgeneABCC4chr13:95858786chr13:100755137ENST00000431522-82193_113387860.0TransmembraneHelical
TgenePCCAchr13:95858786chr13:100755137ENST00000376279023181_37835682.0DomainATP-grasp
TgenePCCAchr13:95858786chr13:100755137ENST0000037627902362_50935682.0DomainBiotin carboxylation
TgenePCCAchr13:95858786chr13:100755137ENST00000376279023653_72835682.0DomainBiotinyl-binding
TgenePCCAchr13:95858786chr13:100755137ENST00000376285024181_37835729.0DomainATP-grasp
TgenePCCAchr13:95858786chr13:100755137ENST0000037628502462_50935729.0DomainBiotin carboxylation
TgenePCCAchr13:95858786chr13:100755137ENST00000376285024653_72835729.0DomainBiotinyl-binding
TgenePCCAchr13:95858786chr13:100755137ENST00000376286023181_3780703.0DomainATP-grasp
TgenePCCAchr13:95858786chr13:100755137ENST0000037628602362_5090703.0DomainBiotin carboxylation
TgenePCCAchr13:95858786chr13:100755137ENST00000376286023653_7280703.0DomainBiotinyl-binding
TgenePCCAchr13:95858786chr13:100755137ENST00000376279023209_27035682.0Nucleotide bindingATP
TgenePCCAchr13:95858786chr13:100755137ENST00000376285024209_27035729.0Nucleotide bindingATP
TgenePCCAchr13:95858786chr13:100755137ENST00000376286023209_2700703.0Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneABCC4chr13:95858786chr13:100755137ENST00000376887-8311041_12743871326.0DomainABC transporter 2
HgeneABCC4chr13:95858786chr13:100755137ENST00000376887-831410_6333871326.0DomainABC transporter 1
HgeneABCC4chr13:95858786chr13:100755137ENST00000376887-831714_10053871326.0DomainABC transmembrane type-1 2
HgeneABCC4chr13:95858786chr13:100755137ENST00000412704-8301041_12743871279.0DomainABC transporter 2
HgeneABCC4chr13:95858786chr13:100755137ENST00000412704-830410_6333871279.0DomainABC transporter 1
HgeneABCC4chr13:95858786chr13:100755137ENST00000412704-830714_10053871279.0DomainABC transmembrane type-1 2
HgeneABCC4chr13:95858786chr13:100755137ENST00000431522-8211041_1274387860.0DomainABC transporter 2
HgeneABCC4chr13:95858786chr13:100755137ENST00000431522-821410_633387860.0DomainABC transporter 1
HgeneABCC4chr13:95858786chr13:100755137ENST00000431522-821714_1005387860.0DomainABC transmembrane type-1 2
HgeneABCC4chr13:95858786chr13:100755137ENST00000376887-8311322_13253871326.0MotifNote=PDZ-binding
HgeneABCC4chr13:95858786chr13:100755137ENST00000412704-8301322_13253871279.0MotifNote=PDZ-binding
HgeneABCC4chr13:95858786chr13:100755137ENST00000431522-8211322_1325387860.0MotifNote=PDZ-binding
HgeneABCC4chr13:95858786chr13:100755137ENST00000376887-8311075_10823871326.0Nucleotide bindingATP 2
HgeneABCC4chr13:95858786chr13:100755137ENST00000376887-831445_4523871326.0Nucleotide bindingATP 1
HgeneABCC4chr13:95858786chr13:100755137ENST00000412704-8301075_10823871279.0Nucleotide bindingATP 2
HgeneABCC4chr13:95858786chr13:100755137ENST00000412704-830445_4523871279.0Nucleotide bindingATP 1
HgeneABCC4chr13:95858786chr13:100755137ENST00000431522-8211075_1082387860.0Nucleotide bindingATP 2
HgeneABCC4chr13:95858786chr13:100755137ENST00000431522-821445_452387860.0Nucleotide bindingATP 1
HgeneABCC4chr13:95858786chr13:100755137ENST00000376887-8311038_10583871326.0TransmembraneHelical
HgeneABCC4chr13:95858786chr13:100755137ENST00000376887-831440_4603871326.0TransmembraneHelical
HgeneABCC4chr13:95858786chr13:100755137ENST00000376887-831710_7303871326.0TransmembraneHelical
HgeneABCC4chr13:95858786chr13:100755137ENST00000376887-831771_7913871326.0TransmembraneHelical
HgeneABCC4chr13:95858786chr13:100755137ENST00000376887-831836_8563871326.0TransmembraneHelical
HgeneABCC4chr13:95858786chr13:100755137ENST00000376887-831858_8783871326.0TransmembraneHelical
HgeneABCC4chr13:95858786chr13:100755137ENST00000376887-831954_9743871326.0TransmembraneHelical
HgeneABCC4chr13:95858786chr13:100755137ENST00000376887-831977_9973871326.0TransmembraneHelical
HgeneABCC4chr13:95858786chr13:100755137ENST00000412704-8301038_10583871279.0TransmembraneHelical
HgeneABCC4chr13:95858786chr13:100755137ENST00000412704-830440_4603871279.0TransmembraneHelical
HgeneABCC4chr13:95858786chr13:100755137ENST00000412704-830710_7303871279.0TransmembraneHelical
HgeneABCC4chr13:95858786chr13:100755137ENST00000412704-830771_7913871279.0TransmembraneHelical
HgeneABCC4chr13:95858786chr13:100755137ENST00000412704-830836_8563871279.0TransmembraneHelical
HgeneABCC4chr13:95858786chr13:100755137ENST00000412704-830858_8783871279.0TransmembraneHelical
HgeneABCC4chr13:95858786chr13:100755137ENST00000412704-830954_9743871279.0TransmembraneHelical
HgeneABCC4chr13:95858786chr13:100755137ENST00000412704-830977_9973871279.0TransmembraneHelical
HgeneABCC4chr13:95858786chr13:100755137ENST00000431522-8211038_1058387860.0TransmembraneHelical
HgeneABCC4chr13:95858786chr13:100755137ENST00000431522-821440_460387860.0TransmembraneHelical
HgeneABCC4chr13:95858786chr13:100755137ENST00000431522-821710_730387860.0TransmembraneHelical
HgeneABCC4chr13:95858786chr13:100755137ENST00000431522-821771_791387860.0TransmembraneHelical
HgeneABCC4chr13:95858786chr13:100755137ENST00000431522-821836_856387860.0TransmembraneHelical
HgeneABCC4chr13:95858786chr13:100755137ENST00000431522-821858_878387860.0TransmembraneHelical
HgeneABCC4chr13:95858786chr13:100755137ENST00000431522-821954_974387860.0TransmembraneHelical
HgeneABCC4chr13:95858786chr13:100755137ENST00000431522-821977_997387860.0TransmembraneHelical


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Fusion Gene Sequence for ABCC4-PCCA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>282_282_1_ABCC4-PCCA_ABCC4_chr13_95858786_ENST00000376887_PCCA_chr13_100755137_ENST00000376279_length(transcript)=3483nt_BP=1276nt
GGACAGGCGTGGCGGCCGGAGCCCCAGCATCCCTGCTTGAGGTCCAGGAGCGGAGCCCGCGGCCACCGCCGCCTGATCAGCGCGACCCCG
GCCCGCGCCCGCCCCGCCCGGCAAGATGCTGCCCGTGTACCAGGAGGTGAAGCCCAACCCGCTGCAGGACGCGAACCTCTGCTCACGCGT
GTTCTTCTGGTGGCTCAATCCCTTGTTTAAAATTGGCCATAAACGGAGATTAGAGGAAGATGATATGTATTCAGTGCTGCCAGAAGACCG
CTCACAGCACCTTGGAGAGGAGTTGCAAGGGTTCTGGGATAAAGAAGTTTTAAGAGCTGAGAATGACGCACAGAAGCCTTCTTTAACAAG
AGCAATCATAAAGTGTTACTGGAAATCTTATTTAGTTTTGGGAATTTTTACGTTAATTGAGGAAAGTGCCAAAGTAATCCAGCCCATATT
TTTGGGAAAAATTATTAATTATTTTGAAAATTATGATCCCATGGATTCTGTGGCTTTGAACACAGCGTACGCCTATGCCACGGTGCTGAC
TTTTTGCACGCTCATTTTGGCTATACTGCATCACTTATATTTTTATCACGTTCAGTGTGCTGGGATGAGGTTACGAGTAGCCATGTGCCA
TATGATTTATCGGAAGGCACTTCGTCTTAGTAACATGGCCATGGGGAAGACAACCACAGGCCAGATAGTCAATCTGCTGTCCAATGATGT
GAACAAGTTTGATCAGGTGACAGTGTTCTTACACTTCCTGTGGGCAGGACCACTGCAGGCGATTGCAGTGACTGCCCTACTCTGGATGGA
GATAGGAATATCGTGCCTTGCTGGGATGGCAGTTCTAATCATTCTCCTGCCCTTGCAAAGCTGTTTTGGGAAGTTGTTCTCATCACTGAG
GAGTAAAACTGCAACTTTCACGGATGCCAGGATCAGGACCATGAATGAAGTTATAACTGGTATAAGGATAATAAAAATGTACGCCTGGGA
AAAGTCATTTTCAAATCTTATTACCAATTTGAGAAAGAAGGAGATTTCCAAGATTCTGAGAAGTTCCTGCCTCAGAGGGATGAATTTGGC
TTCATTTTTCAGTGCAAGCAAAATCATCGTGTTTGTGACCTTCACCACCTACGTGCTCCTCGGCAGTGTGATCACAGCCAGCCGCGTGTT
CGTGGCAGTGACGCTGTATGGGGCTGTGCGGCTGACGGTTACCCTCTTCTTCCCCTCAGCCATTGAGAGGGTGTCAGAGGCAATCGTCAG
CATCCGAAGAATCCAGCATGTTCTGTACTATTCAAGACAGTGCTTAATGGTGTCCCGTAATCTTGGTTCAGTGGGATATGATCCTAATGA
AAAAACTTTTGATAAAATTCTTGTTGCTAATAGAGGAGAAATTGCATGTCGGGTTATTAGAACTTGCAAGAAGATGGGCATTAAGACAGT
TGCCATCCACAGTGATGTTGATGCTAGTTCTGTTCATGTGAAAATGGCGGATGAGGCTGTCTGTGTTGGCCCAGCTCCCACCAGTAAAAG
CTACCTCAACATGGATGCCATCATGGAAGCCATTAAGAAAACCAGGGCCCAAGCTGTACATCCAGGTTATGGATTCCTTTCAGAAAACAA
AGAATTTGCCAGATGTTTGGCAGCAGAAGATGTCGTTTTCATTGGACCTGACACACATGCTATTCAAGCCATGGGCGACAAGATTGAAAG
CAAATTATTAGCTAAGAAAGCAGAGGTTAATACAATCCCTGGCTTTGATGGAGTAGTCAAGGATGCAGAAGAAGCTGTCAGAATTGCAAG
GGAAATTGGCTACCCTGTCATGATCAAGGCCTCAGCAGGTGGTGGTGGGAAAGGCATGCGCATTGCTTGGGATGATGAAGAGACCAGGGA
TGGTTTTAGATTGTCATCTCAAGAAGCTGCTTCTAGTTTTGGCGATGATAGACTACTAATAGAAAAATTTATTGATAATCCTCGTCATAT
AGAAATCCAGGTTCTAGGTGATAAACATGGGAATGCTTTATGGCTTAATGAAAGAGAGTGCTCAATTCAGAGAAGAAATCAGAAGGTGGT
GGAGGAAGCACCAAGCATTTTTTTGGATGCGGAGACTCGAAGAGCGATGGGAGAACAAGCTGTAGCTCTTGCCAGAGCAGTAAAATATTC
CTCTGCTGGGACCGTGGAGTTCCTTGTGGACTCTAAGAAGAATTTTTATTTCTTGGAAATGAATACAAGACTCCAGGTTGAGCATCCTGT
CACAGAATGCATTACTGGCCTGGACCTAGTCCAGGAAATGATCCGTGTTGCTAAGGGCTACCCTCTCAGGCACAAACAAGCTGATATTCG
CATCAACGGCTGGGCAGTTGAATGTCGGGTTTATGCTGAGGACCCCTACAAGTCTTTTGGTTTACCATCTATTGGGAGATTGTCTCAGTA
CCAAGAACCGTTACATCTACCTGGTGTCCGAGTGGACAGTGGCATCCAACCAGGAAGTGATATTAGCATTTATTATGATCCTATGATTTC
AAAACTAATCACATATGGCTCTGATAGAACTGAGGCACTGAAGAGAATGGCAGATGCACTGGATAACTATGTTATTCGAGGTGTTACACA
TAATATTGCATTACTTCGAGAGGTGATAATCAACTCACGCTTTGTAAAAGGAGACATCAGCACTAAATTTCTCTCCGATGTGTATCCTGA
TGGCTTCAAAGGACACATGCTAACCAAGAGTGAGAAGAACCAGTTATTGGCAATAGCATCATCATTGTTTGTGGCATTCCAGTTAAGAGC
ACAACATTTTCAAGAAAATTCAAGAATGCCTGTTATTAAACCAGACATAGCCAACTGGGAGCTCTCAGTAAAATTGCATGATAAAGTTCA
TACCGTAGTAGCATCAAACAATGGGTCAGTGTTCTCGGTGGAAGTTGATGGGTCGAAACTAAATGTGACCAGCACGTGGAACCTGGCTTC
GCCCTTATTGTCTGTCAGCGTTGATGGCACTCAGAGGACTGTCCAGTGTCTTTCTCGAGAAGCAGGTGGAAACATGAGCATTCAGTTTCT
TGGTACAGTGGTAGCAGAAGGTCAAGAAATTTGTGTGATTGAAGCCATGAAAATGCAGAATAGTATGACAGCTGGGAAAACTGGCACGGT
GAAATCTGTGCACTGTCAAGCTGGAGACACAGTTGGAGAAGGGGATCTGCTCGTGGAGCTGGAATGAAGGATTTATAACCTTTCAGTCAT
CACCCAATTTAATTAGCCATTTGCATGATGCTTTCACACACAATTGATTCAAGCATTATACAGGAACACCCCTGTGCAGCTACGTTTACG
TCGTCATTTATTCCACAGAGTCAAGACCAATATTCTGCCAAAAAATCACCAATGGAAATTTTCATTGATATAAATACTTGTACATATGAT

>282_282_1_ABCC4-PCCA_ABCC4_chr13_95858786_ENST00000376887_PCCA_chr13_100755137_ENST00000376279_length(amino acids)=1033AA_BP=387
MLPVYQEVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFWDKEVLRAENDAQKPSLTRAIIKCYWK
SYLVLGIFTLIEESAKVIQPIFLGKIINYFENYDPMDSVALNTAYAYATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALR
LSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTD
ARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVITASRVFVAVTLYGA
VRLTVTLFFPSAIERVSEAIVSIRRIQHVLYYSRQCLMVSRNLGSVGYDPNEKTFDKILVANRGEIACRVIRTCKKMGIKTVAIHSDVDA
SSVHVKMADEAVCVGPAPTSKSYLNMDAIMEAIKKTRAQAVHPGYGFLSENKEFARCLAAEDVVFIGPDTHAIQAMGDKIESKLLAKKAE
VNTIPGFDGVVKDAEEAVRIAREIGYPVMIKASAGGGGKGMRIAWDDEETRDGFRLSSQEAASSFGDDRLLIEKFIDNPRHIEIQVLGDK
HGNALWLNERECSIQRRNQKVVEEAPSIFLDAETRRAMGEQAVALARAVKYSSAGTVEFLVDSKKNFYFLEMNTRLQVEHPVTECITGLD
LVQEMIRVAKGYPLRHKQADIRINGWAVECRVYAEDPYKSFGLPSIGRLSQYQEPLHLPGVRVDSGIQPGSDISIYYDPMISKLITYGSD
RTEALKRMADALDNYVIRGVTHNIALLREVIINSRFVKGDISTKFLSDVYPDGFKGHMLTKSEKNQLLAIASSLFVAFQLRAQHFQENSR
MPVIKPDIANWELSVKLHDKVHTVVASNNGSVFSVEVDGSKLNVTSTWNLASPLLSVSVDGTQRTVQCLSREAGGNMSIQFLGTVVAEGQ

--------------------------------------------------------------
>282_282_2_ABCC4-PCCA_ABCC4_chr13_95858786_ENST00000412704_PCCA_chr13_100755137_ENST00000376279_length(transcript)=3487nt_BP=1280nt
GAGCGGACAGGCGTGGCGGCCGGAGCCCCAGCATCCCTGCTTGAGGTCCAGGAGCGGAGCCCGCGGCCACCGCCGCCTGATCAGCGCGAC
CCCGGCCCGCGCCCGCCCCGCCCGGCAAGATGCTGCCCGTGTACCAGGAGGTGAAGCCCAACCCGCTGCAGGACGCGAACCTCTGCTCAC
GCGTGTTCTTCTGGTGGCTCAATCCCTTGTTTAAAATTGGCCATAAACGGAGATTAGAGGAAGATGATATGTATTCAGTGCTGCCAGAAG
ACCGCTCACAGCACCTTGGAGAGGAGTTGCAAGGGTTCTGGGATAAAGAAGTTTTAAGAGCTGAGAATGACGCACAGAAGCCTTCTTTAA
CAAGAGCAATCATAAAGTGTTACTGGAAATCTTATTTAGTTTTGGGAATTTTTACGTTAATTGAGGAAAGTGCCAAAGTAATCCAGCCCA
TATTTTTGGGAAAAATTATTAATTATTTTGAAAATTATGATCCCATGGATTCTGTGGCTTTGAACACAGCGTACGCCTATGCCACGGTGC
TGACTTTTTGCACGCTCATTTTGGCTATACTGCATCACTTATATTTTTATCACGTTCAGTGTGCTGGGATGAGGTTACGAGTAGCCATGT
GCCATATGATTTATCGGAAGGCACTTCGTCTTAGTAACATGGCCATGGGGAAGACAACCACAGGCCAGATAGTCAATCTGCTGTCCAATG
ATGTGAACAAGTTTGATCAGGTGACAGTGTTCTTACACTTCCTGTGGGCAGGACCACTGCAGGCGATTGCAGTGACTGCCCTACTCTGGA
TGGAGATAGGAATATCGTGCCTTGCTGGGATGGCAGTTCTAATCATTCTCCTGCCCTTGCAAAGCTGTTTTGGGAAGTTGTTCTCATCAC
TGAGGAGTAAAACTGCAACTTTCACGGATGCCAGGATCAGGACCATGAATGAAGTTATAACTGGTATAAGGATAATAAAAATGTACGCCT
GGGAAAAGTCATTTTCAAATCTTATTACCAATTTGAGAAAGAAGGAGATTTCCAAGATTCTGAGAAGTTCCTGCCTCAGAGGGATGAATT
TGGCTTCATTTTTCAGTGCAAGCAAAATCATCGTGTTTGTGACCTTCACCACCTACGTGCTCCTCGGCAGTGTGATCACAGCCAGCCGCG
TGTTCGTGGCAGTGACGCTGTATGGGGCTGTGCGGCTGACGGTTACCCTCTTCTTCCCCTCAGCCATTGAGAGGGTGTCAGAGGCAATCG
TCAGCATCCGAAGAATCCAGCATGTTCTGTACTATTCAAGACAGTGCTTAATGGTGTCCCGTAATCTTGGTTCAGTGGGATATGATCCTA
ATGAAAAAACTTTTGATAAAATTCTTGTTGCTAATAGAGGAGAAATTGCATGTCGGGTTATTAGAACTTGCAAGAAGATGGGCATTAAGA
CAGTTGCCATCCACAGTGATGTTGATGCTAGTTCTGTTCATGTGAAAATGGCGGATGAGGCTGTCTGTGTTGGCCCAGCTCCCACCAGTA
AAAGCTACCTCAACATGGATGCCATCATGGAAGCCATTAAGAAAACCAGGGCCCAAGCTGTACATCCAGGTTATGGATTCCTTTCAGAAA
ACAAAGAATTTGCCAGATGTTTGGCAGCAGAAGATGTCGTTTTCATTGGACCTGACACACATGCTATTCAAGCCATGGGCGACAAGATTG
AAAGCAAATTATTAGCTAAGAAAGCAGAGGTTAATACAATCCCTGGCTTTGATGGAGTAGTCAAGGATGCAGAAGAAGCTGTCAGAATTG
CAAGGGAAATTGGCTACCCTGTCATGATCAAGGCCTCAGCAGGTGGTGGTGGGAAAGGCATGCGCATTGCTTGGGATGATGAAGAGACCA
GGGATGGTTTTAGATTGTCATCTCAAGAAGCTGCTTCTAGTTTTGGCGATGATAGACTACTAATAGAAAAATTTATTGATAATCCTCGTC
ATATAGAAATCCAGGTTCTAGGTGATAAACATGGGAATGCTTTATGGCTTAATGAAAGAGAGTGCTCAATTCAGAGAAGAAATCAGAAGG
TGGTGGAGGAAGCACCAAGCATTTTTTTGGATGCGGAGACTCGAAGAGCGATGGGAGAACAAGCTGTAGCTCTTGCCAGAGCAGTAAAAT
ATTCCTCTGCTGGGACCGTGGAGTTCCTTGTGGACTCTAAGAAGAATTTTTATTTCTTGGAAATGAATACAAGACTCCAGGTTGAGCATC
CTGTCACAGAATGCATTACTGGCCTGGACCTAGTCCAGGAAATGATCCGTGTTGCTAAGGGCTACCCTCTCAGGCACAAACAAGCTGATA
TTCGCATCAACGGCTGGGCAGTTGAATGTCGGGTTTATGCTGAGGACCCCTACAAGTCTTTTGGTTTACCATCTATTGGGAGATTGTCTC
AGTACCAAGAACCGTTACATCTACCTGGTGTCCGAGTGGACAGTGGCATCCAACCAGGAAGTGATATTAGCATTTATTATGATCCTATGA
TTTCAAAACTAATCACATATGGCTCTGATAGAACTGAGGCACTGAAGAGAATGGCAGATGCACTGGATAACTATGTTATTCGAGGTGTTA
CACATAATATTGCATTACTTCGAGAGGTGATAATCAACTCACGCTTTGTAAAAGGAGACATCAGCACTAAATTTCTCTCCGATGTGTATC
CTGATGGCTTCAAAGGACACATGCTAACCAAGAGTGAGAAGAACCAGTTATTGGCAATAGCATCATCATTGTTTGTGGCATTCCAGTTAA
GAGCACAACATTTTCAAGAAAATTCAAGAATGCCTGTTATTAAACCAGACATAGCCAACTGGGAGCTCTCAGTAAAATTGCATGATAAAG
TTCATACCGTAGTAGCATCAAACAATGGGTCAGTGTTCTCGGTGGAAGTTGATGGGTCGAAACTAAATGTGACCAGCACGTGGAACCTGG
CTTCGCCCTTATTGTCTGTCAGCGTTGATGGCACTCAGAGGACTGTCCAGTGTCTTTCTCGAGAAGCAGGTGGAAACATGAGCATTCAGT
TTCTTGGTACAGTGGTAGCAGAAGGTCAAGAAATTTGTGTGATTGAAGCCATGAAAATGCAGAATAGTATGACAGCTGGGAAAACTGGCA
CGGTGAAATCTGTGCACTGTCAAGCTGGAGACACAGTTGGAGAAGGGGATCTGCTCGTGGAGCTGGAATGAAGGATTTATAACCTTTCAG
TCATCACCCAATTTAATTAGCCATTTGCATGATGCTTTCACACACAATTGATTCAAGCATTATACAGGAACACCCCTGTGCAGCTACGTT
TACGTCGTCATTTATTCCACAGAGTCAAGACCAATATTCTGCCAAAAAATCACCAATGGAAATTTTCATTGATATAAATACTTGTACATA

>282_282_2_ABCC4-PCCA_ABCC4_chr13_95858786_ENST00000412704_PCCA_chr13_100755137_ENST00000376279_length(amino acids)=1033AA_BP=387
MLPVYQEVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFWDKEVLRAENDAQKPSLTRAIIKCYWK
SYLVLGIFTLIEESAKVIQPIFLGKIINYFENYDPMDSVALNTAYAYATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALR
LSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTD
ARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVITASRVFVAVTLYGA
VRLTVTLFFPSAIERVSEAIVSIRRIQHVLYYSRQCLMVSRNLGSVGYDPNEKTFDKILVANRGEIACRVIRTCKKMGIKTVAIHSDVDA
SSVHVKMADEAVCVGPAPTSKSYLNMDAIMEAIKKTRAQAVHPGYGFLSENKEFARCLAAEDVVFIGPDTHAIQAMGDKIESKLLAKKAE
VNTIPGFDGVVKDAEEAVRIAREIGYPVMIKASAGGGGKGMRIAWDDEETRDGFRLSSQEAASSFGDDRLLIEKFIDNPRHIEIQVLGDK
HGNALWLNERECSIQRRNQKVVEEAPSIFLDAETRRAMGEQAVALARAVKYSSAGTVEFLVDSKKNFYFLEMNTRLQVEHPVTECITGLD
LVQEMIRVAKGYPLRHKQADIRINGWAVECRVYAEDPYKSFGLPSIGRLSQYQEPLHLPGVRVDSGIQPGSDISIYYDPMISKLITYGSD
RTEALKRMADALDNYVIRGVTHNIALLREVIINSRFVKGDISTKFLSDVYPDGFKGHMLTKSEKNQLLAIASSLFVAFQLRAQHFQENSR
MPVIKPDIANWELSVKLHDKVHTVVASNNGSVFSVEVDGSKLNVTSTWNLASPLLSVSVDGTQRTVQCLSREAGGNMSIQFLGTVVAEGQ

--------------------------------------------------------------
>282_282_3_ABCC4-PCCA_ABCC4_chr13_95858786_ENST00000431522_PCCA_chr13_100755137_ENST00000376279_length(transcript)=3487nt_BP=1280nt
GAGCGGACAGGCGTGGCGGCCGGAGCCCCAGCATCCCTGCTTGAGGTCCAGGAGCGGAGCCCGCGGCCACCGCCGCCTGATCAGCGCGAC
CCCGGCCCGCGCCCGCCCCGCCCGGCAAGATGCTGCCCGTGTACCAGGAGGTGAAGCCCAACCCGCTGCAGGACGCGAACCTCTGCTCAC
GCGTGTTCTTCTGGTGGCTCAATCCCTTGTTTAAAATTGGCCATAAACGGAGATTAGAGGAAGATGATATGTATTCAGTGCTGCCAGAAG
ACCGCTCACAGCACCTTGGAGAGGAGTTGCAAGGGTTCTGGGATAAAGAAGTTTTAAGAGCTGAGAATGACGCACAGAAGCCTTCTTTAA
CAAGAGCAATCATAAAGTGTTACTGGAAATCTTATTTAGTTTTGGGAATTTTTACGTTAATTGAGGAAAGTGCCAAAGTAATCCAGCCCA
TATTTTTGGGAAAAATTATTAATTATTTTGAAAATTATGATCCCATGGATTCTGTGGCTTTGAACACAGCGTACGCCTATGCCACGGTGC
TGACTTTTTGCACGCTCATTTTGGCTATACTGCATCACTTATATTTTTATCACGTTCAGTGTGCTGGGATGAGGTTACGAGTAGCCATGT
GCCATATGATTTATCGGAAGGCACTTCGTCTTAGTAACATGGCCATGGGGAAGACAACCACAGGCCAGATAGTCAATCTGCTGTCCAATG
ATGTGAACAAGTTTGATCAGGTGACAGTGTTCTTACACTTCCTGTGGGCAGGACCACTGCAGGCGATTGCAGTGACTGCCCTACTCTGGA
TGGAGATAGGAATATCGTGCCTTGCTGGGATGGCAGTTCTAATCATTCTCCTGCCCTTGCAAAGCTGTTTTGGGAAGTTGTTCTCATCAC
TGAGGAGTAAAACTGCAACTTTCACGGATGCCAGGATCAGGACCATGAATGAAGTTATAACTGGTATAAGGATAATAAAAATGTACGCCT
GGGAAAAGTCATTTTCAAATCTTATTACCAATTTGAGAAAGAAGGAGATTTCCAAGATTCTGAGAAGTTCCTGCCTCAGAGGGATGAATT
TGGCTTCATTTTTCAGTGCAAGCAAAATCATCGTGTTTGTGACCTTCACCACCTACGTGCTCCTCGGCAGTGTGATCACAGCCAGCCGCG
TGTTCGTGGCAGTGACGCTGTATGGGGCTGTGCGGCTGACGGTTACCCTCTTCTTCCCCTCAGCCATTGAGAGGGTGTCAGAGGCAATCG
TCAGCATCCGAAGAATCCAGCATGTTCTGTACTATTCAAGACAGTGCTTAATGGTGTCCCGTAATCTTGGTTCAGTGGGATATGATCCTA
ATGAAAAAACTTTTGATAAAATTCTTGTTGCTAATAGAGGAGAAATTGCATGTCGGGTTATTAGAACTTGCAAGAAGATGGGCATTAAGA
CAGTTGCCATCCACAGTGATGTTGATGCTAGTTCTGTTCATGTGAAAATGGCGGATGAGGCTGTCTGTGTTGGCCCAGCTCCCACCAGTA
AAAGCTACCTCAACATGGATGCCATCATGGAAGCCATTAAGAAAACCAGGGCCCAAGCTGTACATCCAGGTTATGGATTCCTTTCAGAAA
ACAAAGAATTTGCCAGATGTTTGGCAGCAGAAGATGTCGTTTTCATTGGACCTGACACACATGCTATTCAAGCCATGGGCGACAAGATTG
AAAGCAAATTATTAGCTAAGAAAGCAGAGGTTAATACAATCCCTGGCTTTGATGGAGTAGTCAAGGATGCAGAAGAAGCTGTCAGAATTG
CAAGGGAAATTGGCTACCCTGTCATGATCAAGGCCTCAGCAGGTGGTGGTGGGAAAGGCATGCGCATTGCTTGGGATGATGAAGAGACCA
GGGATGGTTTTAGATTGTCATCTCAAGAAGCTGCTTCTAGTTTTGGCGATGATAGACTACTAATAGAAAAATTTATTGATAATCCTCGTC
ATATAGAAATCCAGGTTCTAGGTGATAAACATGGGAATGCTTTATGGCTTAATGAAAGAGAGTGCTCAATTCAGAGAAGAAATCAGAAGG
TGGTGGAGGAAGCACCAAGCATTTTTTTGGATGCGGAGACTCGAAGAGCGATGGGAGAACAAGCTGTAGCTCTTGCCAGAGCAGTAAAAT
ATTCCTCTGCTGGGACCGTGGAGTTCCTTGTGGACTCTAAGAAGAATTTTTATTTCTTGGAAATGAATACAAGACTCCAGGTTGAGCATC
CTGTCACAGAATGCATTACTGGCCTGGACCTAGTCCAGGAAATGATCCGTGTTGCTAAGGGCTACCCTCTCAGGCACAAACAAGCTGATA
TTCGCATCAACGGCTGGGCAGTTGAATGTCGGGTTTATGCTGAGGACCCCTACAAGTCTTTTGGTTTACCATCTATTGGGAGATTGTCTC
AGTACCAAGAACCGTTACATCTACCTGGTGTCCGAGTGGACAGTGGCATCCAACCAGGAAGTGATATTAGCATTTATTATGATCCTATGA
TTTCAAAACTAATCACATATGGCTCTGATAGAACTGAGGCACTGAAGAGAATGGCAGATGCACTGGATAACTATGTTATTCGAGGTGTTA
CACATAATATTGCATTACTTCGAGAGGTGATAATCAACTCACGCTTTGTAAAAGGAGACATCAGCACTAAATTTCTCTCCGATGTGTATC
CTGATGGCTTCAAAGGACACATGCTAACCAAGAGTGAGAAGAACCAGTTATTGGCAATAGCATCATCATTGTTTGTGGCATTCCAGTTAA
GAGCACAACATTTTCAAGAAAATTCAAGAATGCCTGTTATTAAACCAGACATAGCCAACTGGGAGCTCTCAGTAAAATTGCATGATAAAG
TTCATACCGTAGTAGCATCAAACAATGGGTCAGTGTTCTCGGTGGAAGTTGATGGGTCGAAACTAAATGTGACCAGCACGTGGAACCTGG
CTTCGCCCTTATTGTCTGTCAGCGTTGATGGCACTCAGAGGACTGTCCAGTGTCTTTCTCGAGAAGCAGGTGGAAACATGAGCATTCAGT
TTCTTGGTACAGTGGTAGCAGAAGGTCAAGAAATTTGTGTGATTGAAGCCATGAAAATGCAGAATAGTATGACAGCTGGGAAAACTGGCA
CGGTGAAATCTGTGCACTGTCAAGCTGGAGACACAGTTGGAGAAGGGGATCTGCTCGTGGAGCTGGAATGAAGGATTTATAACCTTTCAG
TCATCACCCAATTTAATTAGCCATTTGCATGATGCTTTCACACACAATTGATTCAAGCATTATACAGGAACACCCCTGTGCAGCTACGTT
TACGTCGTCATTTATTCCACAGAGTCAAGACCAATATTCTGCCAAAAAATCACCAATGGAAATTTTCATTGATATAAATACTTGTACATA

>282_282_3_ABCC4-PCCA_ABCC4_chr13_95858786_ENST00000431522_PCCA_chr13_100755137_ENST00000376279_length(amino acids)=1033AA_BP=387
MLPVYQEVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFWDKEVLRAENDAQKPSLTRAIIKCYWK
SYLVLGIFTLIEESAKVIQPIFLGKIINYFENYDPMDSVALNTAYAYATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALR
LSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTD
ARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVITASRVFVAVTLYGA
VRLTVTLFFPSAIERVSEAIVSIRRIQHVLYYSRQCLMVSRNLGSVGYDPNEKTFDKILVANRGEIACRVIRTCKKMGIKTVAIHSDVDA
SSVHVKMADEAVCVGPAPTSKSYLNMDAIMEAIKKTRAQAVHPGYGFLSENKEFARCLAAEDVVFIGPDTHAIQAMGDKIESKLLAKKAE
VNTIPGFDGVVKDAEEAVRIAREIGYPVMIKASAGGGGKGMRIAWDDEETRDGFRLSSQEAASSFGDDRLLIEKFIDNPRHIEIQVLGDK
HGNALWLNERECSIQRRNQKVVEEAPSIFLDAETRRAMGEQAVALARAVKYSSAGTVEFLVDSKKNFYFLEMNTRLQVEHPVTECITGLD
LVQEMIRVAKGYPLRHKQADIRINGWAVECRVYAEDPYKSFGLPSIGRLSQYQEPLHLPGVRVDSGIQPGSDISIYYDPMISKLITYGSD
RTEALKRMADALDNYVIRGVTHNIALLREVIINSRFVKGDISTKFLSDVYPDGFKGHMLTKSEKNQLLAIASSLFVAFQLRAQHFQENSR
MPVIKPDIANWELSVKLHDKVHTVVASNNGSVFSVEVDGSKLNVTSTWNLASPLLSVSVDGTQRTVQCLSREAGGNMSIQFLGTVVAEGQ

--------------------------------------------------------------
>282_282_4_ABCC4-PCCA_ABCC4_chr13_95858786_ENST00000536256_PCCA_chr13_100755137_ENST00000376279_length(transcript)=3262nt_BP=1055nt
GAGCGGACAGGCGTGGCGGCCGGAGCCCCAGCATCCCTGCTTGAGGTCCAGGAGCGGAGCCCGCGGCCACCGCCGCCTGATCAGCGCGAC
CCCGGCCCGCGCCCGCCCCGCCCGGCAAGATGCTGCCCGTGTACCAGGAGGTGAAGCCCAACCCGCTGCAGGACGCGAACCTCTGCTCAC
GCGTGTTCTTCTGGTGGCTCAATCCCTTGTTTAAAATTGGCCATAAACGGAGATTAGAGGAAGATGATATGTATTCAGTGCTGCCAGAAG
ACCGCTCACAGCACCTTGGAGAGGAGTTGCAAGGGTTCTGGGATAAAGAAGTTTTAAGAGCTGAGAATGACGCACAGAAGCCTTCTTTAA
CAAGAGCAATCATAAAGTGTTACTGGAAATCTTATTTAGTTTTGGGAATTTTTACGTTAATTGAGGCACTTCGTCTTAGTAACATGGCCA
TGGGGAAGACAACCACAGGCCAGATAGTCAATCTGCTGTCCAATGATGTGAACAAGTTTGATCAGGTGACAGTGTTCTTACACTTCCTGT
GGGCAGGACCACTGCAGGCGATTGCAGTGACTGCCCTACTCTGGATGGAGATAGGAATATCGTGCCTTGCTGGGATGGCAGTTCTAATCA
TTCTCCTGCCCTTGCAAAGCTGTTTTGGGAAGTTGTTCTCATCACTGAGGAGTAAAACTGCAACTTTCACGGATGCCAGGATCAGGACCA
TGAATGAAGTTATAACTGGTATAAGGATAATAAAAATGTACGCCTGGGAAAAGTCATTTTCAAATCTTATTACCAATTTGAGAAAGAAGG
AGATTTCCAAGATTCTGAGAAGTTCCTGCCTCAGAGGGATGAATTTGGCTTCATTTTTCAGTGCAAGCAAAATCATCGTGTTTGTGACCT
TCACCACCTACGTGCTCCTCGGCAGTGTGATCACAGCCAGCCGCGTGTTCGTGGCAGTGACGCTGTATGGGGCTGTGCGGCTGACGGTTA
CCCTCTTCTTCCCCTCAGCCATTGAGAGGGTGTCAGAGGCAATCGTCAGCATCCGAAGAATCCAGCATGTTCTGTACTATTCAAGACAGT
GCTTAATGGTGTCCCGTAATCTTGGTTCAGTGGGATATGATCCTAATGAAAAAACTTTTGATAAAATTCTTGTTGCTAATAGAGGAGAAA
TTGCATGTCGGGTTATTAGAACTTGCAAGAAGATGGGCATTAAGACAGTTGCCATCCACAGTGATGTTGATGCTAGTTCTGTTCATGTGA
AAATGGCGGATGAGGCTGTCTGTGTTGGCCCAGCTCCCACCAGTAAAAGCTACCTCAACATGGATGCCATCATGGAAGCCATTAAGAAAA
CCAGGGCCCAAGCTGTACATCCAGGTTATGGATTCCTTTCAGAAAACAAAGAATTTGCCAGATGTTTGGCAGCAGAAGATGTCGTTTTCA
TTGGACCTGACACACATGCTATTCAAGCCATGGGCGACAAGATTGAAAGCAAATTATTAGCTAAGAAAGCAGAGGTTAATACAATCCCTG
GCTTTGATGGAGTAGTCAAGGATGCAGAAGAAGCTGTCAGAATTGCAAGGGAAATTGGCTACCCTGTCATGATCAAGGCCTCAGCAGGTG
GTGGTGGGAAAGGCATGCGCATTGCTTGGGATGATGAAGAGACCAGGGATGGTTTTAGATTGTCATCTCAAGAAGCTGCTTCTAGTTTTG
GCGATGATAGACTACTAATAGAAAAATTTATTGATAATCCTCGTCATATAGAAATCCAGGTTCTAGGTGATAAACATGGGAATGCTTTAT
GGCTTAATGAAAGAGAGTGCTCAATTCAGAGAAGAAATCAGAAGGTGGTGGAGGAAGCACCAAGCATTTTTTTGGATGCGGAGACTCGAA
GAGCGATGGGAGAACAAGCTGTAGCTCTTGCCAGAGCAGTAAAATATTCCTCTGCTGGGACCGTGGAGTTCCTTGTGGACTCTAAGAAGA
ATTTTTATTTCTTGGAAATGAATACAAGACTCCAGGTTGAGCATCCTGTCACAGAATGCATTACTGGCCTGGACCTAGTCCAGGAAATGA
TCCGTGTTGCTAAGGGCTACCCTCTCAGGCACAAACAAGCTGATATTCGCATCAACGGCTGGGCAGTTGAATGTCGGGTTTATGCTGAGG
ACCCCTACAAGTCTTTTGGTTTACCATCTATTGGGAGATTGTCTCAGTACCAAGAACCGTTACATCTACCTGGTGTCCGAGTGGACAGTG
GCATCCAACCAGGAAGTGATATTAGCATTTATTATGATCCTATGATTTCAAAACTAATCACATATGGCTCTGATAGAACTGAGGCACTGA
AGAGAATGGCAGATGCACTGGATAACTATGTTATTCGAGGTGTTACACATAATATTGCATTACTTCGAGAGGTGATAATCAACTCACGCT
TTGTAAAAGGAGACATCAGCACTAAATTTCTCTCCGATGTGTATCCTGATGGCTTCAAAGGACACATGCTAACCAAGAGTGAGAAGAACC
AGTTATTGGCAATAGCATCATCATTGTTTGTGGCATTCCAGTTAAGAGCACAACATTTTCAAGAAAATTCAAGAATGCCTGTTATTAAAC
CAGACATAGCCAACTGGGAGCTCTCAGTAAAATTGCATGATAAAGTTCATACCGTAGTAGCATCAAACAATGGGTCAGTGTTCTCGGTGG
AAGTTGATGGGTCGAAACTAAATGTGACCAGCACGTGGAACCTGGCTTCGCCCTTATTGTCTGTCAGCGTTGATGGCACTCAGAGGACTG
TCCAGTGTCTTTCTCGAGAAGCAGGTGGAAACATGAGCATTCAGTTTCTTGGTACAGTGGTAGCAGAAGGTCAAGAAATTTGTGTGATTG
AAGCCATGAAAATGCAGAATAGTATGACAGCTGGGAAAACTGGCACGGTGAAATCTGTGCACTGTCAAGCTGGAGACACAGTTGGAGAAG
GGGATCTGCTCGTGGAGCTGGAATGAAGGATTTATAACCTTTCAGTCATCACCCAATTTAATTAGCCATTTGCATGATGCTTTCACACAC
AATTGATTCAAGCATTATACAGGAACACCCCTGTGCAGCTACGTTTACGTCGTCATTTATTCCACAGAGTCAAGACCAATATTCTGCCAA
AAAATCACCAATGGAAATTTTCATTGATATAAATACTTGTACATATGATTTGTACTTCTGCTGTGAGATTCCCTAGTGTCAAAATTAAAT

>282_282_4_ABCC4-PCCA_ABCC4_chr13_95858786_ENST00000536256_PCCA_chr13_100755137_ENST00000376279_length(amino acids)=958AA_BP=312
MLPVYQEVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFWDKEVLRAENDAQKPSLTRAIIKCYWK
SYLVLGIFTLIEALRLSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFG
KLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSV
ITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEAIVSIRRIQHVLYYSRQCLMVSRNLGSVGYDPNEKTFDKILVANRGEIACRVIRTCK
KMGIKTVAIHSDVDASSVHVKMADEAVCVGPAPTSKSYLNMDAIMEAIKKTRAQAVHPGYGFLSENKEFARCLAAEDVVFIGPDTHAIQA
MGDKIESKLLAKKAEVNTIPGFDGVVKDAEEAVRIAREIGYPVMIKASAGGGGKGMRIAWDDEETRDGFRLSSQEAASSFGDDRLLIEKF
IDNPRHIEIQVLGDKHGNALWLNERECSIQRRNQKVVEEAPSIFLDAETRRAMGEQAVALARAVKYSSAGTVEFLVDSKKNFYFLEMNTR
LQVEHPVTECITGLDLVQEMIRVAKGYPLRHKQADIRINGWAVECRVYAEDPYKSFGLPSIGRLSQYQEPLHLPGVRVDSGIQPGSDISI
YYDPMISKLITYGSDRTEALKRMADALDNYVIRGVTHNIALLREVIINSRFVKGDISTKFLSDVYPDGFKGHMLTKSEKNQLLAIASSLF
VAFQLRAQHFQENSRMPVIKPDIANWELSVKLHDKVHTVVASNNGSVFSVEVDGSKLNVTSTWNLASPLLSVSVDGTQRTVQCLSREAGG

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Fusion Gene PPI Analysis for ABCC4-PCCA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ABCC4-PCCA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ABCC4-PCCA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource