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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:AGAP3-GRM3 (FusionGDB2 ID:2822)

Fusion Gene Summary for AGAP3-GRM3

check button Fusion gene summary
Fusion gene informationFusion gene name: AGAP3-GRM3
Fusion gene ID: 2822
HgeneTgene
Gene symbol

AGAP3

GRM3

Gene ID

116988

2913

Gene nameArfGAP with GTPase domain, ankyrin repeat and PH domain 3glutamate metabotropic receptor 3
SynonymsAGAP-3|CENTG3|CRAG|MRIP-1|cnt-g3GLUR3|GPRC1C|MGLUR3|mGlu3
Cytomap

7q36.1

7q21.11-q21.12

Type of geneprotein-codingprotein-coding
Descriptionarf-GAP with GTPase, ANK repeat and PH domain-containing protein 3CRAM-associated GTPaseCRMP (collapsin response mediator protein) associatedMR1-interacting proteincentaurin-gamma-3metabotropic glutamate receptor 3glutamate receptor, metabotropic 3
Modification date2020031320200313
UniProtAcc

Q96P47

Q14832

Ensembl transtripts involved in fusion geneENST00000397238, ENST00000473312, 
ENST00000479901, ENST00000335367, 
ENST00000463381, ENST00000476375, 
ENST00000361669, ENST00000536043, 
ENST00000546348, ENST00000394720, 
ENST00000439827, 
Fusion gene scores* DoF score15 X 6 X 10=9006 X 6 X 3=108
# samples 146
** MAII scorelog2(14/900*10)=-2.68449817427207
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/108*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AGAP3 [Title/Abstract] AND GRM3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAGAP3(150784159)-GRM3(86479686), # samples:1
Anticipated loss of major functional domain due to fusion event.AGAP3-GRM3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
AGAP3-GRM3 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
AGAP3-GRM3 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
AGAP3-GRM3 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across AGAP3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across GRM3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-68-8250-01AAGAP3chr7

150784159

-GRM3chr7

86479686

+


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Fusion Gene ORF analysis for AGAP3-GRM3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000397238ENST00000361669AGAP3chr7

150784159

-GRM3chr7

86479686

+
Frame-shiftENST00000397238ENST00000536043AGAP3chr7

150784159

-GRM3chr7

86479686

+
Frame-shiftENST00000397238ENST00000546348AGAP3chr7

150784159

-GRM3chr7

86479686

+
Frame-shiftENST00000473312ENST00000361669AGAP3chr7

150784159

-GRM3chr7

86479686

+
Frame-shiftENST00000473312ENST00000536043AGAP3chr7

150784159

-GRM3chr7

86479686

+
Frame-shiftENST00000473312ENST00000546348AGAP3chr7

150784159

-GRM3chr7

86479686

+
Frame-shiftENST00000479901ENST00000361669AGAP3chr7

150784159

-GRM3chr7

86479686

+
Frame-shiftENST00000479901ENST00000536043AGAP3chr7

150784159

-GRM3chr7

86479686

+
Frame-shiftENST00000479901ENST00000546348AGAP3chr7

150784159

-GRM3chr7

86479686

+
In-frameENST00000397238ENST00000394720AGAP3chr7

150784159

-GRM3chr7

86479686

+
In-frameENST00000397238ENST00000439827AGAP3chr7

150784159

-GRM3chr7

86479686

+
In-frameENST00000473312ENST00000394720AGAP3chr7

150784159

-GRM3chr7

86479686

+
In-frameENST00000473312ENST00000439827AGAP3chr7

150784159

-GRM3chr7

86479686

+
In-frameENST00000479901ENST00000394720AGAP3chr7

150784159

-GRM3chr7

86479686

+
In-frameENST00000479901ENST00000439827AGAP3chr7

150784159

-GRM3chr7

86479686

+
intron-3CDSENST00000335367ENST00000361669AGAP3chr7

150784159

-GRM3chr7

86479686

+
intron-3CDSENST00000335367ENST00000394720AGAP3chr7

150784159

-GRM3chr7

86479686

+
intron-3CDSENST00000335367ENST00000439827AGAP3chr7

150784159

-GRM3chr7

86479686

+
intron-3CDSENST00000335367ENST00000536043AGAP3chr7

150784159

-GRM3chr7

86479686

+
intron-3CDSENST00000335367ENST00000546348AGAP3chr7

150784159

-GRM3chr7

86479686

+
intron-3CDSENST00000463381ENST00000361669AGAP3chr7

150784159

-GRM3chr7

86479686

+
intron-3CDSENST00000463381ENST00000394720AGAP3chr7

150784159

-GRM3chr7

86479686

+
intron-3CDSENST00000463381ENST00000439827AGAP3chr7

150784159

-GRM3chr7

86479686

+
intron-3CDSENST00000463381ENST00000536043AGAP3chr7

150784159

-GRM3chr7

86479686

+
intron-3CDSENST00000463381ENST00000546348AGAP3chr7

150784159

-GRM3chr7

86479686

+
intron-3CDSENST00000476375ENST00000361669AGAP3chr7

150784159

-GRM3chr7

86479686

+
intron-3CDSENST00000476375ENST00000394720AGAP3chr7

150784159

-GRM3chr7

86479686

+
intron-3CDSENST00000476375ENST00000439827AGAP3chr7

150784159

-GRM3chr7

86479686

+
intron-3CDSENST00000476375ENST00000536043AGAP3chr7

150784159

-GRM3chr7

86479686

+
intron-3CDSENST00000476375ENST00000546348AGAP3chr7

150784159

-GRM3chr7

86479686

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000473312AGAP3chr7150784159-ENST00000439827GRM3chr786479686+6473310620206
ENST00000473312AGAP3chr7150784159-ENST00000394720GRM3chr786479686+6473310620206
ENST00000479901AGAP3chr7150784159-ENST00000439827GRM3chr786479686+6473310620206
ENST00000479901AGAP3chr7150784159-ENST00000394720GRM3chr786479686+6473310620206
ENST00000397238AGAP3chr7150784159-ENST00000439827GRM3chr786479686+6473310620206
ENST00000397238AGAP3chr7150784159-ENST00000394720GRM3chr786479686+6473310620206

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000473312ENST00000439827AGAP3chr7150784159-GRM3chr786479686+0.0104330680.98956686
ENST00000473312ENST00000394720AGAP3chr7150784159-GRM3chr786479686+0.0104330680.98956686
ENST00000479901ENST00000439827AGAP3chr7150784159-GRM3chr786479686+0.0104330680.98956686
ENST00000479901ENST00000394720AGAP3chr7150784159-GRM3chr786479686+0.0104330680.98956686
ENST00000397238ENST00000439827AGAP3chr7150784159-GRM3chr786479686+0.0104330680.98956686
ENST00000397238ENST00000394720AGAP3chr7150784159-GRM3chr786479686+0.0104330680.98956686

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Fusion Genomic Features for AGAP3-GRM3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for AGAP3-GRM3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:150784159/chr7:86479686)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AGAP3

Q96P47

GRM3

Q14832

FUNCTION: GTPase-activating protein for the ADP ribosylation factor family (Potential). GTPase which may be involved in the degradation of expanded polyglutamine proteins through the ubiquitin-proteasome pathway. {ECO:0000269|PubMed:16461359, ECO:0000305}.FUNCTION: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity. {ECO:0000269|PubMed:8840013}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAGAP3chr7:150784159chr7:86479686ENST00000397238-11898_105110912.0Nucleotide bindingGTP
TgeneGRM3chr7:150784159chr7:86479686ENST0000036166936829_879797880.0Topological domainCytoplasmic
TgeneGRM3chr7:150784159chr7:86479686ENST0000039472025600_613439536.0Topological domainCytoplasmic
TgeneGRM3chr7:150784159chr7:86479686ENST0000039472025635_645439536.0Topological domainExtracellular
TgeneGRM3chr7:150784159chr7:86479686ENST0000039472025665_688439536.0Topological domainCytoplasmic
TgeneGRM3chr7:150784159chr7:86479686ENST0000039472025710_734439536.0Topological domainExtracellular
TgeneGRM3chr7:150784159chr7:86479686ENST0000039472025757_769439536.0Topological domainCytoplasmic
TgeneGRM3chr7:150784159chr7:86479686ENST0000039472025793_802439536.0Topological domainExtracellular
TgeneGRM3chr7:150784159chr7:86479686ENST0000039472025829_879439536.0Topological domainCytoplasmic
TgeneGRM3chr7:150784159chr7:86479686ENST0000043982725600_613441538.0Topological domainCytoplasmic
TgeneGRM3chr7:150784159chr7:86479686ENST0000043982725635_645441538.0Topological domainExtracellular
TgeneGRM3chr7:150784159chr7:86479686ENST0000043982725665_688441538.0Topological domainCytoplasmic
TgeneGRM3chr7:150784159chr7:86479686ENST0000043982725710_734441538.0Topological domainExtracellular
TgeneGRM3chr7:150784159chr7:86479686ENST0000043982725757_769441538.0Topological domainCytoplasmic
TgeneGRM3chr7:150784159chr7:86479686ENST0000043982725793_802441538.0Topological domainExtracellular
TgeneGRM3chr7:150784159chr7:86479686ENST0000043982725829_879441538.0Topological domainCytoplasmic
TgeneGRM3chr7:150784159chr7:86479686ENST0000036166936803_828797880.0TransmembraneHelical%3B Name%3D7
TgeneGRM3chr7:150784159chr7:86479686ENST0000039472025577_599439536.0TransmembraneHelical%3B Name%3D1
TgeneGRM3chr7:150784159chr7:86479686ENST0000039472025614_634439536.0TransmembraneHelical%3B Name%3D2
TgeneGRM3chr7:150784159chr7:86479686ENST0000039472025646_664439536.0TransmembraneHelical%3B Name%3D3
TgeneGRM3chr7:150784159chr7:86479686ENST0000039472025689_709439536.0TransmembraneHelical%3B Name%3D4
TgeneGRM3chr7:150784159chr7:86479686ENST0000039472025735_756439536.0TransmembraneHelical%3B Name%3D5
TgeneGRM3chr7:150784159chr7:86479686ENST0000039472025770_792439536.0TransmembraneHelical%3B Name%3D6
TgeneGRM3chr7:150784159chr7:86479686ENST0000039472025803_828439536.0TransmembraneHelical%3B Name%3D7
TgeneGRM3chr7:150784159chr7:86479686ENST0000043982725577_599441538.0TransmembraneHelical%3B Name%3D1
TgeneGRM3chr7:150784159chr7:86479686ENST0000043982725614_634441538.0TransmembraneHelical%3B Name%3D2
TgeneGRM3chr7:150784159chr7:86479686ENST0000043982725646_664441538.0TransmembraneHelical%3B Name%3D3
TgeneGRM3chr7:150784159chr7:86479686ENST0000043982725689_709441538.0TransmembraneHelical%3B Name%3D4
TgeneGRM3chr7:150784159chr7:86479686ENST0000043982725735_756441538.0TransmembraneHelical%3B Name%3D5
TgeneGRM3chr7:150784159chr7:86479686ENST0000043982725770_792441538.0TransmembraneHelical%3B Name%3D6
TgeneGRM3chr7:150784159chr7:86479686ENST0000043982725803_828441538.0TransmembraneHelical%3B Name%3D7

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAGAP3chr7:150784159chr7:86479686ENST00000397238-118367_605110912.0DomainPH
HgeneAGAP3chr7:150784159chr7:86479686ENST00000397238-118626_746110912.0DomainArf-GAP
HgeneAGAP3chr7:150784159chr7:86479686ENST00000397238-118142_146110912.0Nucleotide bindingGTP
HgeneAGAP3chr7:150784159chr7:86479686ENST00000397238-118198_201110912.0Nucleotide bindingGTP
HgeneAGAP3chr7:150784159chr7:86479686ENST00000397238-11884_375110912.0RegionNote=Small GTPase-like
HgeneAGAP3chr7:150784159chr7:86479686ENST00000397238-118748_777110912.0RepeatNote=ANK 1
HgeneAGAP3chr7:150784159chr7:86479686ENST00000397238-118785_814110912.0RepeatNote=ANK 2
HgeneAGAP3chr7:150784159chr7:86479686ENST00000397238-118818_847110912.0RepeatNote=ANK 3
HgeneAGAP3chr7:150784159chr7:86479686ENST00000397238-118641_664110912.0Zinc fingerC4-type
TgeneGRM3chr7:150784159chr7:86479686ENST0000036166936172_174797880.0RegionGlutamate binding
TgeneGRM3chr7:150784159chr7:86479686ENST0000039472025172_174439536.0RegionGlutamate binding
TgeneGRM3chr7:150784159chr7:86479686ENST0000043982725172_174441538.0RegionGlutamate binding
TgeneGRM3chr7:150784159chr7:86479686ENST000003616693623_576797880.0Topological domainExtracellular
TgeneGRM3chr7:150784159chr7:86479686ENST0000036166936600_613797880.0Topological domainCytoplasmic
TgeneGRM3chr7:150784159chr7:86479686ENST0000036166936635_645797880.0Topological domainExtracellular
TgeneGRM3chr7:150784159chr7:86479686ENST0000036166936665_688797880.0Topological domainCytoplasmic
TgeneGRM3chr7:150784159chr7:86479686ENST0000036166936710_734797880.0Topological domainExtracellular
TgeneGRM3chr7:150784159chr7:86479686ENST0000036166936757_769797880.0Topological domainCytoplasmic
TgeneGRM3chr7:150784159chr7:86479686ENST0000036166936793_802797880.0Topological domainExtracellular
TgeneGRM3chr7:150784159chr7:86479686ENST000003947202523_576439536.0Topological domainExtracellular
TgeneGRM3chr7:150784159chr7:86479686ENST000004398272523_576441538.0Topological domainExtracellular
TgeneGRM3chr7:150784159chr7:86479686ENST0000036166936577_599797880.0TransmembraneHelical%3B Name%3D1
TgeneGRM3chr7:150784159chr7:86479686ENST0000036166936614_634797880.0TransmembraneHelical%3B Name%3D2
TgeneGRM3chr7:150784159chr7:86479686ENST0000036166936646_664797880.0TransmembraneHelical%3B Name%3D3
TgeneGRM3chr7:150784159chr7:86479686ENST0000036166936689_709797880.0TransmembraneHelical%3B Name%3D4
TgeneGRM3chr7:150784159chr7:86479686ENST0000036166936735_756797880.0TransmembraneHelical%3B Name%3D5
TgeneGRM3chr7:150784159chr7:86479686ENST0000036166936770_792797880.0TransmembraneHelical%3B Name%3D6


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Fusion Gene Sequence for AGAP3-GRM3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>2822_2822_1_AGAP3-GRM3_AGAP3_chr7_150784159_ENST00000397238_GRM3_chr7_86479686_ENST00000394720_length(transcript)=647nt_BP=331nt
ATGAACTTCCAGGCGGGCGGGGGGCAGAGCCCGCAGCAGCAGCAGAGCCTGGCGGCTCCGGGGGGCGGCGGCGCTGCCGCGCAGCAGCTC
GTCTGCGGCGGGCAGTTCGGCGGCGCGGGGCCCGGGGCCGGGGGCGGCGGCGGCCCCTCGCAGCAGCTGGCCGGCGGGCCCCCCCAGCAG
TTCGCGCTCTCCAACTCCGCGGCCATCCGGGCCGAGATCCAGCGCTTCGAGTCCGTGCATCCCAATATCTACGCCATCTACGACCTGATC
GAGCGCATCGAGGATTTGGCGCTGCAGAACCAGATCCGGGAGCACGTCATCTCCATCGAGGGTGCAGACGACAACCATGTGCATCTCTGT
CAGCCTGAGTGGCTTTGTGGTCTTGGGCTGTTTGTTTGCACCCAAGGTTCACATCATCCTGTTTCAACCCCAGAAGAATGTTGTCACACA
CAGACTGCACCTCAACAGGTTCAGTGTCAGTGGAACTGGGACCACATACTCTCAGTCCTCTGCAAGCACGTATGTGCCAACGGTGTGCAA
TGGGCGGGAAGTCCTCGACTCCACCACCTCATCTCTGTGATTGTGAATTGCAGTTCAGTTCTTGTGTTTTTAGACTGTTAGACAAAAGTG

>2822_2822_1_AGAP3-GRM3_AGAP3_chr7_150784159_ENST00000397238_GRM3_chr7_86479686_ENST00000394720_length(amino acids)=206AA_BP=110
MNFQAGGGQSPQQQQSLAAPGGGGAAAQQLVCGGQFGGAGPGAGGGGGPSQQLAGGPPQQFALSNSAAIRAEIQRFESVHPNIYAIYDLI
ERIEDLALQNQIREHVISIEGADDNHVHLCQPEWLCGLGLFVCTQGSHHPVSTPEECCHTQTAPQQVQCQWNWDHILSVLCKHVCANGVQ

--------------------------------------------------------------
>2822_2822_2_AGAP3-GRM3_AGAP3_chr7_150784159_ENST00000397238_GRM3_chr7_86479686_ENST00000439827_length(transcript)=647nt_BP=331nt
ATGAACTTCCAGGCGGGCGGGGGGCAGAGCCCGCAGCAGCAGCAGAGCCTGGCGGCTCCGGGGGGCGGCGGCGCTGCCGCGCAGCAGCTC
GTCTGCGGCGGGCAGTTCGGCGGCGCGGGGCCCGGGGCCGGGGGCGGCGGCGGCCCCTCGCAGCAGCTGGCCGGCGGGCCCCCCCAGCAG
TTCGCGCTCTCCAACTCCGCGGCCATCCGGGCCGAGATCCAGCGCTTCGAGTCCGTGCATCCCAATATCTACGCCATCTACGACCTGATC
GAGCGCATCGAGGATTTGGCGCTGCAGAACCAGATCCGGGAGCACGTCATCTCCATCGAGGGTGCAGACGACAACCATGTGCATCTCTGT
CAGCCTGAGTGGCTTTGTGGTCTTGGGCTGTTTGTTTGCACCCAAGGTTCACATCATCCTGTTTCAACCCCAGAAGAATGTTGTCACACA
CAGACTGCACCTCAACAGGTTCAGTGTCAGTGGAACTGGGACCACATACTCTCAGTCCTCTGCAAGCACGTATGTGCCAACGGTGTGCAA
TGGGCGGGAAGTCCTCGACTCCACCACCTCATCTCTGTGATTGTGAATTGCAGTTCAGTTCTTGTGTTTTTAGACTGTTAGACAAAAGTG

>2822_2822_2_AGAP3-GRM3_AGAP3_chr7_150784159_ENST00000397238_GRM3_chr7_86479686_ENST00000439827_length(amino acids)=206AA_BP=110
MNFQAGGGQSPQQQQSLAAPGGGGAAAQQLVCGGQFGGAGPGAGGGGGPSQQLAGGPPQQFALSNSAAIRAEIQRFESVHPNIYAIYDLI
ERIEDLALQNQIREHVISIEGADDNHVHLCQPEWLCGLGLFVCTQGSHHPVSTPEECCHTQTAPQQVQCQWNWDHILSVLCKHVCANGVQ

--------------------------------------------------------------
>2822_2822_3_AGAP3-GRM3_AGAP3_chr7_150784159_ENST00000473312_GRM3_chr7_86479686_ENST00000394720_length(transcript)=647nt_BP=331nt
ATGAACTTCCAGGCGGGCGGGGGGCAGAGCCCGCAGCAGCAGCAGAGCCTGGCGGCTCCGGGGGGCGGCGGCGCTGCCGCGCAGCAGCTC
GTCTGCGGCGGGCAGTTCGGCGGCGCGGGGCCCGGGGCCGGGGGCGGCGGCGGCCCCTCGCAGCAGCTGGCCGGCGGGCCCCCCCAGCAG
TTCGCGCTCTCCAACTCCGCGGCCATCCGGGCCGAGATCCAGCGCTTCGAGTCCGTGCATCCCAATATCTACGCCATCTACGACCTGATC
GAGCGCATCGAGGATTTGGCGCTGCAGAACCAGATCCGGGAGCACGTCATCTCCATCGAGGGTGCAGACGACAACCATGTGCATCTCTGT
CAGCCTGAGTGGCTTTGTGGTCTTGGGCTGTTTGTTTGCACCCAAGGTTCACATCATCCTGTTTCAACCCCAGAAGAATGTTGTCACACA
CAGACTGCACCTCAACAGGTTCAGTGTCAGTGGAACTGGGACCACATACTCTCAGTCCTCTGCAAGCACGTATGTGCCAACGGTGTGCAA
TGGGCGGGAAGTCCTCGACTCCACCACCTCATCTCTGTGATTGTGAATTGCAGTTCAGTTCTTGTGTTTTTAGACTGTTAGACAAAAGTG

>2822_2822_3_AGAP3-GRM3_AGAP3_chr7_150784159_ENST00000473312_GRM3_chr7_86479686_ENST00000394720_length(amino acids)=206AA_BP=110
MNFQAGGGQSPQQQQSLAAPGGGGAAAQQLVCGGQFGGAGPGAGGGGGPSQQLAGGPPQQFALSNSAAIRAEIQRFESVHPNIYAIYDLI
ERIEDLALQNQIREHVISIEGADDNHVHLCQPEWLCGLGLFVCTQGSHHPVSTPEECCHTQTAPQQVQCQWNWDHILSVLCKHVCANGVQ

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>2822_2822_4_AGAP3-GRM3_AGAP3_chr7_150784159_ENST00000473312_GRM3_chr7_86479686_ENST00000439827_length(transcript)=647nt_BP=331nt
ATGAACTTCCAGGCGGGCGGGGGGCAGAGCCCGCAGCAGCAGCAGAGCCTGGCGGCTCCGGGGGGCGGCGGCGCTGCCGCGCAGCAGCTC
GTCTGCGGCGGGCAGTTCGGCGGCGCGGGGCCCGGGGCCGGGGGCGGCGGCGGCCCCTCGCAGCAGCTGGCCGGCGGGCCCCCCCAGCAG
TTCGCGCTCTCCAACTCCGCGGCCATCCGGGCCGAGATCCAGCGCTTCGAGTCCGTGCATCCCAATATCTACGCCATCTACGACCTGATC
GAGCGCATCGAGGATTTGGCGCTGCAGAACCAGATCCGGGAGCACGTCATCTCCATCGAGGGTGCAGACGACAACCATGTGCATCTCTGT
CAGCCTGAGTGGCTTTGTGGTCTTGGGCTGTTTGTTTGCACCCAAGGTTCACATCATCCTGTTTCAACCCCAGAAGAATGTTGTCACACA
CAGACTGCACCTCAACAGGTTCAGTGTCAGTGGAACTGGGACCACATACTCTCAGTCCTCTGCAAGCACGTATGTGCCAACGGTGTGCAA
TGGGCGGGAAGTCCTCGACTCCACCACCTCATCTCTGTGATTGTGAATTGCAGTTCAGTTCTTGTGTTTTTAGACTGTTAGACAAAAGTG

>2822_2822_4_AGAP3-GRM3_AGAP3_chr7_150784159_ENST00000473312_GRM3_chr7_86479686_ENST00000439827_length(amino acids)=206AA_BP=110
MNFQAGGGQSPQQQQSLAAPGGGGAAAQQLVCGGQFGGAGPGAGGGGGPSQQLAGGPPQQFALSNSAAIRAEIQRFESVHPNIYAIYDLI
ERIEDLALQNQIREHVISIEGADDNHVHLCQPEWLCGLGLFVCTQGSHHPVSTPEECCHTQTAPQQVQCQWNWDHILSVLCKHVCANGVQ

--------------------------------------------------------------
>2822_2822_5_AGAP3-GRM3_AGAP3_chr7_150784159_ENST00000479901_GRM3_chr7_86479686_ENST00000394720_length(transcript)=647nt_BP=331nt
ATGAACTTCCAGGCGGGCGGGGGGCAGAGCCCGCAGCAGCAGCAGAGCCTGGCGGCTCCGGGGGGCGGCGGCGCTGCCGCGCAGCAGCTC
GTCTGCGGCGGGCAGTTCGGCGGCGCGGGGCCCGGGGCCGGGGGCGGCGGCGGCCCCTCGCAGCAGCTGGCCGGCGGGCCCCCCCAGCAG
TTCGCGCTCTCCAACTCCGCGGCCATCCGGGCCGAGATCCAGCGCTTCGAGTCCGTGCATCCCAATATCTACGCCATCTACGACCTGATC
GAGCGCATCGAGGATTTGGCGCTGCAGAACCAGATCCGGGAGCACGTCATCTCCATCGAGGGTGCAGACGACAACCATGTGCATCTCTGT
CAGCCTGAGTGGCTTTGTGGTCTTGGGCTGTTTGTTTGCACCCAAGGTTCACATCATCCTGTTTCAACCCCAGAAGAATGTTGTCACACA
CAGACTGCACCTCAACAGGTTCAGTGTCAGTGGAACTGGGACCACATACTCTCAGTCCTCTGCAAGCACGTATGTGCCAACGGTGTGCAA
TGGGCGGGAAGTCCTCGACTCCACCACCTCATCTCTGTGATTGTGAATTGCAGTTCAGTTCTTGTGTTTTTAGACTGTTAGACAAAAGTG

>2822_2822_5_AGAP3-GRM3_AGAP3_chr7_150784159_ENST00000479901_GRM3_chr7_86479686_ENST00000394720_length(amino acids)=206AA_BP=110
MNFQAGGGQSPQQQQSLAAPGGGGAAAQQLVCGGQFGGAGPGAGGGGGPSQQLAGGPPQQFALSNSAAIRAEIQRFESVHPNIYAIYDLI
ERIEDLALQNQIREHVISIEGADDNHVHLCQPEWLCGLGLFVCTQGSHHPVSTPEECCHTQTAPQQVQCQWNWDHILSVLCKHVCANGVQ

--------------------------------------------------------------
>2822_2822_6_AGAP3-GRM3_AGAP3_chr7_150784159_ENST00000479901_GRM3_chr7_86479686_ENST00000439827_length(transcript)=647nt_BP=331nt
ATGAACTTCCAGGCGGGCGGGGGGCAGAGCCCGCAGCAGCAGCAGAGCCTGGCGGCTCCGGGGGGCGGCGGCGCTGCCGCGCAGCAGCTC
GTCTGCGGCGGGCAGTTCGGCGGCGCGGGGCCCGGGGCCGGGGGCGGCGGCGGCCCCTCGCAGCAGCTGGCCGGCGGGCCCCCCCAGCAG
TTCGCGCTCTCCAACTCCGCGGCCATCCGGGCCGAGATCCAGCGCTTCGAGTCCGTGCATCCCAATATCTACGCCATCTACGACCTGATC
GAGCGCATCGAGGATTTGGCGCTGCAGAACCAGATCCGGGAGCACGTCATCTCCATCGAGGGTGCAGACGACAACCATGTGCATCTCTGT
CAGCCTGAGTGGCTTTGTGGTCTTGGGCTGTTTGTTTGCACCCAAGGTTCACATCATCCTGTTTCAACCCCAGAAGAATGTTGTCACACA
CAGACTGCACCTCAACAGGTTCAGTGTCAGTGGAACTGGGACCACATACTCTCAGTCCTCTGCAAGCACGTATGTGCCAACGGTGTGCAA
TGGGCGGGAAGTCCTCGACTCCACCACCTCATCTCTGTGATTGTGAATTGCAGTTCAGTTCTTGTGTTTTTAGACTGTTAGACAAAAGTG

>2822_2822_6_AGAP3-GRM3_AGAP3_chr7_150784159_ENST00000479901_GRM3_chr7_86479686_ENST00000439827_length(amino acids)=206AA_BP=110
MNFQAGGGQSPQQQQSLAAPGGGGAAAQQLVCGGQFGGAGPGAGGGGGPSQQLAGGPPQQFALSNSAAIRAEIQRFESVHPNIYAIYDLI
ERIEDLALQNQIREHVISIEGADDNHVHLCQPEWLCGLGLFVCTQGSHHPVSTPEECCHTQTAPQQVQCQWNWDHILSVLCKHVCANGVQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for AGAP3-GRM3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for AGAP3-GRM3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for AGAP3-GRM3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource