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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FAM102A-PTGES2 (FusionGDB2 ID:28292)

Fusion Gene Summary for FAM102A-PTGES2

check button Fusion gene summary
Fusion gene informationFusion gene name: FAM102A-PTGES2
Fusion gene ID: 28292
HgeneTgene
Gene symbol

FAM102A

PTGES2

Gene ID

399665

80142

Gene namefamily with sequence similarity 102 member Aprostaglandin E synthase 2
SynonymsC9orf132|EEIG1|SYM-3A|bA203J24.7C9orf15|GBF-1|GBF1|PGES2|mPGES-2
Cytomap

9q34.11

9q34.11

Type of geneprotein-codingprotein-coding
Descriptionprotein FAM102AC230093N12Rikearly estrogen-induced gene 1 proteinsym-3 homolog Aprostaglandin E synthase 2GATE-binding factor 1gamma-interferon-activated transcriptional element-binding factor 1mPGE synthase-2membrane-associated prostaglandin E synthase 2microsomal prostaglandin E synthase-2prostaglandin-H(2) E-isomerase
Modification date2020032020200313
UniProtAcc

Q5T9C2

.
Ensembl transtripts involved in fusion geneENST00000373095, ENST00000300434, 
ENST00000373084, 		ENST00000277462, 
ENST00000483625, ENST00000338961, 
Fusion gene scores* DoF score11 X 7 X 10=7704 X 3 X 5=60
# samples 166
** MAII scorelog2(16/770*10)=-2.2667865406949
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/60*10)=0
Context

PubMed: FAM102A [Title/Abstract] AND PTGES2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFAM102A(130742271)-PTGES2(130887720), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across FAM102A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PTGES2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-28-5204-01AFAM102Achr9

130742271

-PTGES2chr9

130887720

-
ChimerDB4GBMTCGA-28-5204FAM102Achr9

130742270

-PTGES2chr9

130887720

-
ChimerDB4LUADTCGA-69-A59K-01AFAM102Achr9

130715854

-PTGES2chr9

130887720

-
ChimerDB4UCECTCGA-D1-A16G-01AFAM102Achr9

130742271

-PTGES2chr9

130887720

-


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Fusion Gene ORF analysis for FAM102A-PTGES2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000373095ENST00000277462FAM102Achr9

130742271

-PTGES2chr9

130887720

-
5CDS-5UTRENST00000373095ENST00000277462FAM102Achr9

130742270

-PTGES2chr9

130887720

-
5CDS-5UTRENST00000373095ENST00000277462FAM102Achr9

130715854

-PTGES2chr9

130887720

-
5CDS-5UTRENST00000373095ENST00000483625FAM102Achr9

130742271

-PTGES2chr9

130887720

-
5CDS-5UTRENST00000373095ENST00000483625FAM102Achr9

130742270

-PTGES2chr9

130887720

-
5CDS-5UTRENST00000373095ENST00000483625FAM102Achr9

130715854

-PTGES2chr9

130887720

-
In-frameENST00000373095ENST00000338961FAM102Achr9

130742271

-PTGES2chr9

130887720

-
In-frameENST00000373095ENST00000338961FAM102Achr9

130742270

-PTGES2chr9

130887720

-
In-frameENST00000373095ENST00000338961FAM102Achr9

130715854

-PTGES2chr9

130887720

-
intron-3CDSENST00000300434ENST00000338961FAM102Achr9

130742271

-PTGES2chr9

130887720

-
intron-3CDSENST00000300434ENST00000338961FAM102Achr9

130742270

-PTGES2chr9

130887720

-
intron-3CDSENST00000300434ENST00000338961FAM102Achr9

130715854

-PTGES2chr9

130887720

-
intron-3CDSENST00000373084ENST00000338961FAM102Achr9

130742271

-PTGES2chr9

130887720

-
intron-3CDSENST00000373084ENST00000338961FAM102Achr9

130742270

-PTGES2chr9

130887720

-
intron-3CDSENST00000373084ENST00000338961FAM102Achr9

130715854

-PTGES2chr9

130887720

-
intron-5UTRENST00000300434ENST00000277462FAM102Achr9

130742271

-PTGES2chr9

130887720

-
intron-5UTRENST00000300434ENST00000277462FAM102Achr9

130742270

-PTGES2chr9

130887720

-
intron-5UTRENST00000300434ENST00000277462FAM102Achr9

130715854

-PTGES2chr9

130887720

-
intron-5UTRENST00000300434ENST00000483625FAM102Achr9

130742271

-PTGES2chr9

130887720

-
intron-5UTRENST00000300434ENST00000483625FAM102Achr9

130742270

-PTGES2chr9

130887720

-
intron-5UTRENST00000300434ENST00000483625FAM102Achr9

130715854

-PTGES2chr9

130887720

-
intron-5UTRENST00000373084ENST00000277462FAM102Achr9

130742271

-PTGES2chr9

130887720

-
intron-5UTRENST00000373084ENST00000277462FAM102Achr9

130742270

-PTGES2chr9

130887720

-
intron-5UTRENST00000373084ENST00000277462FAM102Achr9

130715854

-PTGES2chr9

130887720

-
intron-5UTRENST00000373084ENST00000483625FAM102Achr9

130742271

-PTGES2chr9

130887720

-
intron-5UTRENST00000373084ENST00000483625FAM102Achr9

130742270

-PTGES2chr9

130887720

-
intron-5UTRENST00000373084ENST00000483625FAM102Achr9

130715854

-PTGES2chr9

130887720

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000373095FAM102Achr9130742271-ENST00000338961PTGES2chr9130887720-18295222041376390
ENST00000373095FAM102Achr9130715854-ENST00000338961PTGES2chr9130887720-19806733761527383
ENST00000373095FAM102Achr9130742270-ENST00000338961PTGES2chr9130887720-18295222041376390

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000373095ENST00000338961FAM102Achr9130742271-PTGES2chr9130887720-0.0047240780.99527586
ENST00000373095ENST00000338961FAM102Achr9130715854-PTGES2chr9130887720-0.0046740320.9953259
ENST00000373095ENST00000338961FAM102Achr9130742270-PTGES2chr9130887720-0.0047240780.99527586

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Fusion Genomic Features for FAM102A-PTGES2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for FAM102A-PTGES2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:130742271/chr9:130887720)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FAM102A

Q5T9C2

.
FUNCTION: May play a role in estrogen action. {ECO:0000269|PubMed:14605097}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePTGES2chr9:130715854chr9:130887720ENST0000033896107263_37793378.0DomainNote=GST C-terminal
TgenePTGES2chr9:130715854chr9:130887720ENST000003389610790_19393378.0DomainGlutaredoxin
TgenePTGES2chr9:130742270chr9:130887720ENST0000033896107263_37793378.0DomainNote=GST C-terminal
TgenePTGES2chr9:130742270chr9:130887720ENST000003389610790_19393378.0DomainGlutaredoxin
TgenePTGES2chr9:130742271chr9:130887720ENST0000033896107263_37793378.0DomainNote=GST C-terminal
TgenePTGES2chr9:130742271chr9:130887720ENST000003389610790_19393378.0DomainGlutaredoxin
TgenePTGES2chr9:130715854chr9:130887720ENST0000033896107164_16593378.0RegionGlutathione binding
TgenePTGES2chr9:130742270chr9:130887720ENST0000033896107164_16593378.0RegionGlutathione binding
TgenePTGES2chr9:130742271chr9:130887720ENST0000033896107164_16593378.0RegionGlutathione binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFAM102Achr9:130715854chr9:130887720ENST00000373084-18157_2680243.0Compositional biasNote=Ser-rich
HgeneFAM102Achr9:130715854chr9:130887720ENST00000373095-311157_26899385.0Compositional biasNote=Ser-rich
HgeneFAM102Achr9:130742270chr9:130887720ENST00000373084-18157_2680243.0Compositional biasNote=Ser-rich
HgeneFAM102Achr9:130742270chr9:130887720ENST00000373095-111157_26848385.0Compositional biasNote=Ser-rich
HgeneFAM102Achr9:130742271chr9:130887720ENST00000373084-18157_2680243.0Compositional biasNote=Ser-rich
HgeneFAM102Achr9:130742271chr9:130887720ENST00000373095-111157_26848385.0Compositional biasNote=Ser-rich
HgeneFAM102Achr9:130715854chr9:130887720ENST00000373084-182_1450243.0DomainC2 NT-type
HgeneFAM102Achr9:130715854chr9:130887720ENST00000373095-3112_14599385.0DomainC2 NT-type
HgeneFAM102Achr9:130742270chr9:130887720ENST00000373084-182_1450243.0DomainC2 NT-type
HgeneFAM102Achr9:130742270chr9:130887720ENST00000373095-1112_14548385.0DomainC2 NT-type
HgeneFAM102Achr9:130742271chr9:130887720ENST00000373084-182_1450243.0DomainC2 NT-type
HgeneFAM102Achr9:130742271chr9:130887720ENST00000373095-1112_14548385.0DomainC2 NT-type
TgenePTGES2chr9:130715854chr9:130887720ENST00000338961071_5793378.0Topological domainLumenal
TgenePTGES2chr9:130715854chr9:130887720ENST000003389610775_37793378.0Topological domainCytoplasmic
TgenePTGES2chr9:130742270chr9:130887720ENST00000338961071_5793378.0Topological domainLumenal
TgenePTGES2chr9:130742270chr9:130887720ENST000003389610775_37793378.0Topological domainCytoplasmic
TgenePTGES2chr9:130742271chr9:130887720ENST00000338961071_5793378.0Topological domainLumenal
TgenePTGES2chr9:130742271chr9:130887720ENST000003389610775_37793378.0Topological domainCytoplasmic
TgenePTGES2chr9:130715854chr9:130887720ENST000003389610758_7493378.0TransmembraneHelical
TgenePTGES2chr9:130742270chr9:130887720ENST000003389610758_7493378.0TransmembraneHelical
TgenePTGES2chr9:130742271chr9:130887720ENST000003389610758_7493378.0TransmembraneHelical


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Fusion Gene Sequence for FAM102A-PTGES2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>28292_28292_1_FAM102A-PTGES2_FAM102A_chr9_130715854_ENST00000373095_PTGES2_chr9_130887720_ENST00000338961_length(transcript)=1980nt_BP=673nt
CCGCGCGGCGTGAGCTCCCCGGACATCGCGTCTCGGGATGCTGCAAGCCAGCGCGGCCGCTCGCGCGCAGCCCCGCACCTCCGCCCCTGC
CTCTGCCTCCTGGGCCATGCCCTGCTGTTTACATGCCGGTGAGGTCCCCGGCCGCTCCGAACCCCTCCGAGCCCCGGCTCCCCGAGGGTG
AAGCCCGCCGGCCCGCGAACTGGACTGGTGGATCTCTCAGACCTGGGGCCCCGGACTCCGATCTCCGCCGTCTCCGCCACCATCAGGGCG
GGATCCGGCTCTGGTGTTTTGAGGAGGGGGTGTGGTGTAGGGAAAGGAATCCCGTCCCTCTCCACCTTTTTTCGCCTTCGGGGCTTCAGA
CTCAGGGAACTCGCTCATGGCTTTCTTGATGAAGAAGAAGAAATTCAAATTCCAAACTACTTTCACCCTGGAGGAGCTGACTGCGGTTCC
CTTCGTGAACGGGGTCCTCTTCTGCAAGGTCCGGCTGCTGGATGGAGGGGATTTTGTCAGCTTGTCGTCAAGGGAGGAGGTACAGGAGAA
CTGTGTGCGGTGGCGAAAGAGGTTCACCTTCGTGTGTAAGATGAGTGCTAACCCGGCCACCGGCCTGCTGGACCCCTGTGTCTTCCGTGT
GTCTGTGCGCAAGGAGCTGAAAGGCGGGAAGGCTTATTCCAAGCTCTCCCTGTCCAGCCGCCTGCAGCTGACCCTGTACCAGTACAAGAC
GTGTCCCTTCTGCAGCAAGGTCCGAGCCTTCCTCGACTTCCATGCCCTGCCCTACCAGGTGGTGGAGGTGAACCCTGTGCGCAGGGCTGA
GATCAAGTTCTCCTCCTACAGAAAGGTGCCCATCCTGGTGGCCCAGGAAGGAGAAAGCTCGCAACAACTAAATGACTCCTCTGTCATCAT
CAGCGCCCTCAAGACCTACCTGGTGTCGGGGCAGCCCCTGGAAGAGATCATCACCTACTACCCAGCCATGAAGGCTGTGAACGAGCAGGG
CAAGGAGGTGACCGAGTTCGGCAATAAGTACTGGCTCATGCTCAACGAGAAGGAGGCCCAGCAAGTGTATGGTGGGAAGGAGGCCAGGAC
GGAGGAGATGAAGTGGCGGCAGTGGGCGGACGACTGGCTGGTGCACCTGATCTCCCCCAATGTGTACCGCACGCCCACCGAGGCTCTGGC
GTCCTTTGACTACATTGTCCGCGAGGGCAAGTTCGGAGCCGTGGAGGGTGCCGTGGCCAAGTACATGGGTGCAGCGGCCATGTACCTCAT
CAGCAAGCGACTCAAGAGCAGGCACCGCCTCCAGGACAACGTGCGCGAGGACCTCTATGAGGCTGCTGACAAGTGGGTGGCTGCTGTGGG
CAAGGACCGGCCCTTCATGGGGGGCCAGAAGCCGAATCTCGCTGATTTGGCGGTGTATGGCGTGCTGCGTGTGATGGAGGGGCTGGATGC
GTTCGATGACCTGATGCAGCACACGCACATCCAGCCCTGGTACCTGCGGGTGGAGAGGGCCATCACCGAGGCCTCCCCAGCGCACTGAAT
GTCCCCGCGCAGAGCAGAGGGAAGGCAGCGGAAGACGCCAGCTGCCAGGGCCTGGGGCCACTGGGCCAGCGCCTGGCGATACTGGTTGGG
GGCAGGATCATTCTGCCCCTTGTCCACGCACCCCCACCAGCCCTCTCGCTTCTAACACAGGGCACCTGCTGGGGCTCAGGGATGTTAGGG
ACGAGTTCCAGCCCTGCCACTGCCCTGGGGCGACCCCTCCCTGTCCCTGCCTCCCTGCTCTGCCGCCCCTCTTCCTGGACCCTCAGTGGC
TGTCCCATGGCTACATCCTGTGGGTGGGGGCCCTCGACAGGACAGCAGGACGGTTTGTTTTCAGTGGAATCCCATCCCTGGGTTCCCCTG
GTTCCCACTCTTCCCAAGCCTCCCGGGACTGGGACATGTTTGCAATAAAGGAAAGGTTTGTGGCGCCTGTCATGGCAGGCATCTCATGGA

>28292_28292_1_FAM102A-PTGES2_FAM102A_chr9_130715854_ENST00000373095_PTGES2_chr9_130887720_ENST00000338961_length(amino acids)=383AA_BP=99
MAFLMKKKKFKFQTTFTLEELTAVPFVNGVLFCKVRLLDGGDFVSLSSREEVQENCVRWRKRFTFVCKMSANPATGLLDPCVFRVSVRKE
LKGGKAYSKLSLSSRLQLTLYQYKTCPFCSKVRAFLDFHALPYQVVEVNPVRRAEIKFSSYRKVPILVAQEGESSQQLNDSSVIISALKT
YLVSGQPLEEIITYYPAMKAVNEQGKEVTEFGNKYWLMLNEKEAQQVYGGKEARTEEMKWRQWADDWLVHLISPNVYRTPTEALASFDYI
VREGKFGAVEGAVAKYMGAAAMYLISKRLKSRHRLQDNVREDLYEAADKWVAAVGKDRPFMGGQKPNLADLAVYGVLRVMEGLDAFDDLM

--------------------------------------------------------------
>28292_28292_2_FAM102A-PTGES2_FAM102A_chr9_130742270_ENST00000373095_PTGES2_chr9_130887720_ENST00000338961_length(transcript)=1829nt_BP=522nt
CCGCGCGGCGTGAGCTCCCCGGACATCGCGTCTCGGGATGCTGCAAGCCAGCGCGGCCGCTCGCGCGCAGCCCCGCACCTCCGCCCCTGC
CTCTGCCTCCTGGGCCATGCCCTGCTGTTTACATGCCGGTGAGGTCCCCGGCCGCTCCGAACCCCTCCGAGCCCCGGCTCCCCGAGGGTG
AAGCCCGCCGGCCCGCGAACTGGACTGGTGGATCTCTCAGACCTGGGGCCCCGGACTCCGATCTCCGCCGTCTCCGCCACCATCAGGGCG
GGATCCGGCTCTGGTGTTTTGAGGAGGGGGTGTGGTGTAGGGAAAGGAATCCCGTCCCTCTCCACCTTTTTTCGCCTTCGGGGCTTCAGA
CTCAGGGAACTCGCTCATGGCTTTCTTGATGAAGAAGAAGAAATTCAAATTCCAAACTACTTTCACCCTGGAGGAGCTGACTGCGGTTCC
CTTCGTGAACGGGGTCCTCTTCTGCAAGGTCCGGCTGCTGGATGGAGGGGATTTTGTCAGCTTGTCGTCAAGCTCTCCCTGTCCAGCCGC
CTGCAGCTGACCCTGTACCAGTACAAGACGTGTCCCTTCTGCAGCAAGGTCCGAGCCTTCCTCGACTTCCATGCCCTGCCCTACCAGGTG
GTGGAGGTGAACCCTGTGCGCAGGGCTGAGATCAAGTTCTCCTCCTACAGAAAGGTGCCCATCCTGGTGGCCCAGGAAGGAGAAAGCTCG
CAACAACTAAATGACTCCTCTGTCATCATCAGCGCCCTCAAGACCTACCTGGTGTCGGGGCAGCCCCTGGAAGAGATCATCACCTACTAC
CCAGCCATGAAGGCTGTGAACGAGCAGGGCAAGGAGGTGACCGAGTTCGGCAATAAGTACTGGCTCATGCTCAACGAGAAGGAGGCCCAG
CAAGTGTATGGTGGGAAGGAGGCCAGGACGGAGGAGATGAAGTGGCGGCAGTGGGCGGACGACTGGCTGGTGCACCTGATCTCCCCCAAT
GTGTACCGCACGCCCACCGAGGCTCTGGCGTCCTTTGACTACATTGTCCGCGAGGGCAAGTTCGGAGCCGTGGAGGGTGCCGTGGCCAAG
TACATGGGTGCAGCGGCCATGTACCTCATCAGCAAGCGACTCAAGAGCAGGCACCGCCTCCAGGACAACGTGCGCGAGGACCTCTATGAG
GCTGCTGACAAGTGGGTGGCTGCTGTGGGCAAGGACCGGCCCTTCATGGGGGGCCAGAAGCCGAATCTCGCTGATTTGGCGGTGTATGGC
GTGCTGCGTGTGATGGAGGGGCTGGATGCGTTCGATGACCTGATGCAGCACACGCACATCCAGCCCTGGTACCTGCGGGTGGAGAGGGCC
ATCACCGAGGCCTCCCCAGCGCACTGAATGTCCCCGCGCAGAGCAGAGGGAAGGCAGCGGAAGACGCCAGCTGCCAGGGCCTGGGGCCAC
TGGGCCAGCGCCTGGCGATACTGGTTGGGGGCAGGATCATTCTGCCCCTTGTCCACGCACCCCCACCAGCCCTCTCGCTTCTAACACAGG
GCACCTGCTGGGGCTCAGGGATGTTAGGGACGAGTTCCAGCCCTGCCACTGCCCTGGGGCGACCCCTCCCTGTCCCTGCCTCCCTGCTCT
GCCGCCCCTCTTCCTGGACCCTCAGTGGCTGTCCCATGGCTACATCCTGTGGGTGGGGGCCCTCGACAGGACAGCAGGACGGTTTGTTTT
CAGTGGAATCCCATCCCTGGGTTCCCCTGGTTCCCACTCTTCCCAAGCCTCCCGGGACTGGGACATGTTTGCAATAAAGGAAAGGTTTGT

>28292_28292_2_FAM102A-PTGES2_FAM102A_chr9_130742270_ENST00000373095_PTGES2_chr9_130887720_ENST00000338961_length(amino acids)=390AA_BP=106
MVDLSDLGPRTPISAVSATIRAGSGSGVLRRGCGVGKGIPSLSTFFRLRGFRLRELAHGFLDEEEEIQIPNYFHPGGADCGSLRERGPLL
QGPAAGWRGFCQLVVKLSLSSRLQLTLYQYKTCPFCSKVRAFLDFHALPYQVVEVNPVRRAEIKFSSYRKVPILVAQEGESSQQLNDSSV
IISALKTYLVSGQPLEEIITYYPAMKAVNEQGKEVTEFGNKYWLMLNEKEAQQVYGGKEARTEEMKWRQWADDWLVHLISPNVYRTPTEA
LASFDYIVREGKFGAVEGAVAKYMGAAAMYLISKRLKSRHRLQDNVREDLYEAADKWVAAVGKDRPFMGGQKPNLADLAVYGVLRVMEGL

--------------------------------------------------------------
>28292_28292_3_FAM102A-PTGES2_FAM102A_chr9_130742271_ENST00000373095_PTGES2_chr9_130887720_ENST00000338961_length(transcript)=1829nt_BP=522nt
CCGCGCGGCGTGAGCTCCCCGGACATCGCGTCTCGGGATGCTGCAAGCCAGCGCGGCCGCTCGCGCGCAGCCCCGCACCTCCGCCCCTGC
CTCTGCCTCCTGGGCCATGCCCTGCTGTTTACATGCCGGTGAGGTCCCCGGCCGCTCCGAACCCCTCCGAGCCCCGGCTCCCCGAGGGTG
AAGCCCGCCGGCCCGCGAACTGGACTGGTGGATCTCTCAGACCTGGGGCCCCGGACTCCGATCTCCGCCGTCTCCGCCACCATCAGGGCG
GGATCCGGCTCTGGTGTTTTGAGGAGGGGGTGTGGTGTAGGGAAAGGAATCCCGTCCCTCTCCACCTTTTTTCGCCTTCGGGGCTTCAGA
CTCAGGGAACTCGCTCATGGCTTTCTTGATGAAGAAGAAGAAATTCAAATTCCAAACTACTTTCACCCTGGAGGAGCTGACTGCGGTTCC
CTTCGTGAACGGGGTCCTCTTCTGCAAGGTCCGGCTGCTGGATGGAGGGGATTTTGTCAGCTTGTCGTCAAGCTCTCCCTGTCCAGCCGC
CTGCAGCTGACCCTGTACCAGTACAAGACGTGTCCCTTCTGCAGCAAGGTCCGAGCCTTCCTCGACTTCCATGCCCTGCCCTACCAGGTG
GTGGAGGTGAACCCTGTGCGCAGGGCTGAGATCAAGTTCTCCTCCTACAGAAAGGTGCCCATCCTGGTGGCCCAGGAAGGAGAAAGCTCG
CAACAACTAAATGACTCCTCTGTCATCATCAGCGCCCTCAAGACCTACCTGGTGTCGGGGCAGCCCCTGGAAGAGATCATCACCTACTAC
CCAGCCATGAAGGCTGTGAACGAGCAGGGCAAGGAGGTGACCGAGTTCGGCAATAAGTACTGGCTCATGCTCAACGAGAAGGAGGCCCAG
CAAGTGTATGGTGGGAAGGAGGCCAGGACGGAGGAGATGAAGTGGCGGCAGTGGGCGGACGACTGGCTGGTGCACCTGATCTCCCCCAAT
GTGTACCGCACGCCCACCGAGGCTCTGGCGTCCTTTGACTACATTGTCCGCGAGGGCAAGTTCGGAGCCGTGGAGGGTGCCGTGGCCAAG
TACATGGGTGCAGCGGCCATGTACCTCATCAGCAAGCGACTCAAGAGCAGGCACCGCCTCCAGGACAACGTGCGCGAGGACCTCTATGAG
GCTGCTGACAAGTGGGTGGCTGCTGTGGGCAAGGACCGGCCCTTCATGGGGGGCCAGAAGCCGAATCTCGCTGATTTGGCGGTGTATGGC
GTGCTGCGTGTGATGGAGGGGCTGGATGCGTTCGATGACCTGATGCAGCACACGCACATCCAGCCCTGGTACCTGCGGGTGGAGAGGGCC
ATCACCGAGGCCTCCCCAGCGCACTGAATGTCCCCGCGCAGAGCAGAGGGAAGGCAGCGGAAGACGCCAGCTGCCAGGGCCTGGGGCCAC
TGGGCCAGCGCCTGGCGATACTGGTTGGGGGCAGGATCATTCTGCCCCTTGTCCACGCACCCCCACCAGCCCTCTCGCTTCTAACACAGG
GCACCTGCTGGGGCTCAGGGATGTTAGGGACGAGTTCCAGCCCTGCCACTGCCCTGGGGCGACCCCTCCCTGTCCCTGCCTCCCTGCTCT
GCCGCCCCTCTTCCTGGACCCTCAGTGGCTGTCCCATGGCTACATCCTGTGGGTGGGGGCCCTCGACAGGACAGCAGGACGGTTTGTTTT
CAGTGGAATCCCATCCCTGGGTTCCCCTGGTTCCCACTCTTCCCAAGCCTCCCGGGACTGGGACATGTTTGCAATAAAGGAAAGGTTTGT

>28292_28292_3_FAM102A-PTGES2_FAM102A_chr9_130742271_ENST00000373095_PTGES2_chr9_130887720_ENST00000338961_length(amino acids)=390AA_BP=106
MVDLSDLGPRTPISAVSATIRAGSGSGVLRRGCGVGKGIPSLSTFFRLRGFRLRELAHGFLDEEEEIQIPNYFHPGGADCGSLRERGPLL
QGPAAGWRGFCQLVVKLSLSSRLQLTLYQYKTCPFCSKVRAFLDFHALPYQVVEVNPVRRAEIKFSSYRKVPILVAQEGESSQQLNDSSV
IISALKTYLVSGQPLEEIITYYPAMKAVNEQGKEVTEFGNKYWLMLNEKEAQQVYGGKEARTEEMKWRQWADDWLVHLISPNVYRTPTEA
LASFDYIVREGKFGAVEGAVAKYMGAAAMYLISKRLKSRHRLQDNVREDLYEAADKWVAAVGKDRPFMGGQKPNLADLAVYGVLRVMEGL

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Fusion Gene PPI Analysis for FAM102A-PTGES2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FAM102A-PTGES2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FAM102A-PTGES2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource