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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
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Fusion gene:FAM107B-DCLRE1C (FusionGDB2 ID:28317)

Fusion Gene Summary for FAM107B-DCLRE1C

Fusion gene summary

Fusion gene information	Fusion gene name: FAM107B-DCLRE1C
	Fusion gene ID: 28317
		Hgene	Tgene
	Gene symbol	FAM107B	DCLRE1C
	Gene ID	83641	64421
	Gene name	family with sequence similarity 107 member B	DNA cross-link repair 1C
	Synonyms	C10orf45\|HITS	A-SCID\|DCLREC1C\|RS-SCID\|SCIDA\|SNM1C
	Cytomap	10p13	10p13
	Type of gene	protein-coding	protein-coding
	Description	protein FAM107BFAM107B/CDNF fusionheat shock-inducible tumor small protein	protein artemisDNA cross-link repair 1C (PSO2 homolog, S. cerevisiae)SNM1 homolog CSNM1-like proteinsevere combined immunodeficiency, type a (Athabascan)
	Modification date	20200313	20200313
	UniProtAcc	Q9H098	Q96SD1
	Ensembl transtripts involved in fusion gene	ENST00000181796, ENST00000378458, ENST00000378462, ENST00000378465, ENST00000378467, ENST00000378470, ENST00000468747, ENST00000471815, ENST00000478076, ENST00000479731, ENST00000496330,	ENST00000357717, ENST00000378242, ENST00000378246, ENST00000378249, ENST00000378254, ENST00000378255, ENST00000378258, ENST00000378278, ENST00000378289, ENST00000396817, ENST00000453695, ENST00000492201,
Fusion gene scores	* DoF score	10 X 8 X 3=240	10 X 9 X 4=360
	# samples	10	10
	** MAII score	log2(10/240*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(10/360*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: FAM107B [Title/Abstract] AND DCLRE1C [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	FAM107B(14736470)-DCLRE1C(14966819), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across FAM107B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across DCLRE1C (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	CB054483	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+

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Fusion Gene ORF analysis for FAM107B-DCLRE1C

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000181796	ENST00000357717	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000181796	ENST00000378242	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000181796	ENST00000378246	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000181796	ENST00000378249	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000181796	ENST00000378254	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000181796	ENST00000378255	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000181796	ENST00000378258	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000181796	ENST00000378278	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000181796	ENST00000378289	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000181796	ENST00000396817	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000181796	ENST00000453695	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000181796	ENST00000492201	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000378458	ENST00000357717	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000378458	ENST00000378242	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000378458	ENST00000378246	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000378458	ENST00000378249	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000378458	ENST00000378254	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000378458	ENST00000378255	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000378458	ENST00000378258	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000378458	ENST00000378278	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000378458	ENST00000378289	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000378458	ENST00000396817	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000378458	ENST00000453695	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000378458	ENST00000492201	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000378462	ENST00000357717	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000378462	ENST00000378242	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000378462	ENST00000378246	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000378462	ENST00000378249	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000378462	ENST00000378254	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000378462	ENST00000378255	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000378462	ENST00000378258	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000378462	ENST00000378278	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000378462	ENST00000378289	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000378462	ENST00000396817	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000378462	ENST00000453695	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000378462	ENST00000492201	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000378465	ENST00000357717	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000378465	ENST00000378242	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000378465	ENST00000378246	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000378465	ENST00000378249	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000378465	ENST00000378254	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000378465	ENST00000378255	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000378465	ENST00000378258	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000378465	ENST00000378278	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000378465	ENST00000378289	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000378465	ENST00000396817	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000378465	ENST00000453695	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000378465	ENST00000492201	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000378467	ENST00000357717	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000378467	ENST00000378242	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000378467	ENST00000378246	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000378467	ENST00000378249	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000378467	ENST00000378254	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000378467	ENST00000378255	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000378467	ENST00000378258	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000378467	ENST00000378278	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000378467	ENST00000378289	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000378467	ENST00000396817	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000378467	ENST00000453695	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000378467	ENST00000492201	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000378470	ENST00000357717	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000378470	ENST00000378242	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000378470	ENST00000378246	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000378470	ENST00000378249	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000378470	ENST00000378254	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000378470	ENST00000378255	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000378470	ENST00000378258	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000378470	ENST00000378278	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000378470	ENST00000378289	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000378470	ENST00000396817	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000378470	ENST00000453695	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000378470	ENST00000492201	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000468747	ENST00000357717	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000468747	ENST00000378242	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000468747	ENST00000378246	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000468747	ENST00000378249	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000468747	ENST00000378254	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000468747	ENST00000378255	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000468747	ENST00000378258	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000468747	ENST00000378278	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000468747	ENST00000378289	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000468747	ENST00000396817	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000468747	ENST00000453695	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000468747	ENST00000492201	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000471815	ENST00000357717	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000471815	ENST00000378242	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000471815	ENST00000378246	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000471815	ENST00000378249	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000471815	ENST00000378254	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000471815	ENST00000378255	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000471815	ENST00000378258	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000471815	ENST00000378278	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000471815	ENST00000378289	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000471815	ENST00000396817	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000471815	ENST00000453695	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000471815	ENST00000492201	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000478076	ENST00000357717	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000478076	ENST00000378242	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000478076	ENST00000378246	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000478076	ENST00000378249	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000478076	ENST00000378254	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000478076	ENST00000378255	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000478076	ENST00000378258	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000478076	ENST00000378278	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000478076	ENST00000378289	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000478076	ENST00000396817	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000478076	ENST00000453695	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000478076	ENST00000492201	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000479731	ENST00000357717	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000479731	ENST00000378242	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000479731	ENST00000378246	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000479731	ENST00000378249	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000479731	ENST00000378254	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000479731	ENST00000378255	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000479731	ENST00000378258	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000479731	ENST00000378278	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000479731	ENST00000378289	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000479731	ENST00000396817	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000479731	ENST00000453695	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000479731	ENST00000492201	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000496330	ENST00000357717	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000496330	ENST00000378242	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000496330	ENST00000378246	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000496330	ENST00000378249	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000496330	ENST00000378254	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000496330	ENST00000378255	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000496330	ENST00000378258	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000496330	ENST00000378278	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000496330	ENST00000378289	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000496330	ENST00000396817	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000496330	ENST00000453695	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+
intron-intron	ENST00000496330	ENST00000492201	FAM107B	chr10	14736470	+	DCLRE1C	chr10	14966819	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for FAM107B-DCLRE1C

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for FAM107B-DCLRE1C

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:14736470/:14966819)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
FAM107B Q9H098	DCLRE1C Q96SD1
	FUNCTION: Required for V(D)J recombination, the process by which exons encoding the antigen-binding domains of immunoglobulins and T-cell receptor proteins are assembled from individual V, (D), and J gene segments. V(D)J recombination is initiated by the lymphoid specific RAG endonuclease complex, which generates site specific DNA double strand breaks (DSBs). These DSBs present two types of DNA end structures: hairpin sealed coding ends and phosphorylated blunt signal ends. These ends are independently repaired by the non homologous end joining (NHEJ) pathway to form coding and signal joints respectively. This protein exhibits single-strand specific 5'-3' exonuclease activity in isolation and acquires endonucleolytic activity on 5' and 3' hairpins and overhangs when in a complex with PRKDC. The latter activity is required specifically for the resolution of closed hairpins prior to the formation of the coding joint. May also be required for the repair of complex DSBs induced by ionizing radiation, which require substantial end-processing prior to religation by NHEJ. {ECO:0000269\|PubMed:11336668, ECO:0000269\|PubMed:11955432, ECO:0000269\|PubMed:12055248, ECO:0000269\|PubMed:14744996, ECO:0000269\|PubMed:15071507, ECO:0000269\|PubMed:15456891, ECO:0000269\|PubMed:15468306, ECO:0000269\|PubMed:15574326, ECO:0000269\|PubMed:15574327, ECO:0000269\|PubMed:15811628, ECO:0000269\|PubMed:15936993}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for FAM107B-DCLRE1C

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for FAM107B-DCLRE1C

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for FAM107B-DCLRE1C

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for FAM107B-DCLRE1C

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source