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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FAM126A-TRA2A (FusionGDB2 ID:28441)

Fusion Gene Summary for FAM126A-TRA2A

check button Fusion gene summary
Fusion gene informationFusion gene name: FAM126A-TRA2A
Fusion gene ID: 28441
HgeneTgene
Gene symbol

FAM126A

TRA2A

Gene ID

84668

29896

Gene namefamily with sequence similarity 126 member Atransformer 2 alpha homolog
SynonymsDRCTNNB1A|HCC|HLD5|HYCC1AWMS1|HSU53209
Cytomap

7p15.3

7p15.3

Type of geneprotein-codingprotein-coding
Descriptionhyccindown regulated by Ctnnb1, adown-regulated by CTNNB1 protein Atransformer-2 protein homolog alphaTRA-2 alphaTRA2-alphaTra2alphahtra-2 alphaputative MAPK activating protein PM24transformer-2 alphatransformer-2 protein homolog A
Modification date2020031320200313
UniProtAcc

Q9BYI3

.
Ensembl transtripts involved in fusion geneENST00000409763, ENST00000409923, 
ENST00000432176, ENST00000498833, 
ENST00000474586, ENST00000297071, 
ENST00000392502, ENST00000538367, 
Fusion gene scores* DoF score5 X 5 X 4=1007 X 8 X 5=280
# samples 58
** MAII scorelog2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/280*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FAM126A [Title/Abstract] AND TRA2A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFAM126A(23023563)-TRA2A(23547154), # samples:4
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFAM126A

GO:0046854

phosphatidylinositol phosphorylation

26571211

HgeneFAM126A

GO:0072659

protein localization to plasma membrane

26571211

TgeneTRA2A

GO:0000398

mRNA splicing, via spliceosome

9546399


check buttonFusion gene breakpoints across FAM126A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TRA2A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-D9-A4Z6-01AFAM126Achr7

23023563

-TRA2Achr7

23547154

-
ChimerDB4SKCMTCGA-D9-A4Z6-06AFAM126Achr7

23023563

-TRA2Achr7

23547154

-


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Fusion Gene ORF analysis for FAM126A-TRA2A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000409763ENST00000474586FAM126Achr7

23023563

-TRA2Achr7

23547154

-
5CDS-5UTRENST00000409923ENST00000474586FAM126Achr7

23023563

-TRA2Achr7

23547154

-
5CDS-5UTRENST00000432176ENST00000474586FAM126Achr7

23023563

-TRA2Achr7

23547154

-
In-frameENST00000409763ENST00000297071FAM126Achr7

23023563

-TRA2Achr7

23547154

-
In-frameENST00000409763ENST00000392502FAM126Achr7

23023563

-TRA2Achr7

23547154

-
In-frameENST00000409763ENST00000538367FAM126Achr7

23023563

-TRA2Achr7

23547154

-
In-frameENST00000409923ENST00000297071FAM126Achr7

23023563

-TRA2Achr7

23547154

-
In-frameENST00000409923ENST00000392502FAM126Achr7

23023563

-TRA2Achr7

23547154

-
In-frameENST00000409923ENST00000538367FAM126Achr7

23023563

-TRA2Achr7

23547154

-
In-frameENST00000432176ENST00000297071FAM126Achr7

23023563

-TRA2Achr7

23547154

-
In-frameENST00000432176ENST00000392502FAM126Achr7

23023563

-TRA2Achr7

23547154

-
In-frameENST00000432176ENST00000538367FAM126Achr7

23023563

-TRA2Achr7

23547154

-
intron-3CDSENST00000498833ENST00000297071FAM126Achr7

23023563

-TRA2Achr7

23547154

-
intron-3CDSENST00000498833ENST00000392502FAM126Achr7

23023563

-TRA2Achr7

23547154

-
intron-3CDSENST00000498833ENST00000538367FAM126Achr7

23023563

-TRA2Achr7

23547154

-
intron-5UTRENST00000498833ENST00000474586FAM126Achr7

23023563

-TRA2Achr7

23547154

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000432176FAM126Achr723023563-ENST00000297071TRA2Achr723547154-1489386233709158
ENST00000432176FAM126Achr723023563-ENST00000392502TRA2Achr723547154-1116386233706157
ENST00000432176FAM126Achr723023563-ENST00000538367TRA2Achr723547154-810386233709158
ENST00000409923FAM126Achr723023563-ENST00000297071TRA2Achr723547154-1444341188664158
ENST00000409923FAM126Achr723023563-ENST00000392502TRA2Achr723547154-1071341188661157
ENST00000409923FAM126Achr723023563-ENST00000538367TRA2Achr723547154-765341188664158
ENST00000409763FAM126Achr723023563-ENST00000297071TRA2Achr723547154-1434331178654158
ENST00000409763FAM126Achr723023563-ENST00000392502TRA2Achr723547154-1061331178651157
ENST00000409763FAM126Achr723023563-ENST00000538367TRA2Achr723547154-755331178654158

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000432176ENST00000297071FAM126Achr723023563-TRA2Achr723547154-0.0046920440.995308
ENST00000432176ENST00000392502FAM126Achr723023563-TRA2Achr723547154-0.0058383580.99416167
ENST00000432176ENST00000538367FAM126Achr723023563-TRA2Achr723547154-0.0089349640.99106497
ENST00000409923ENST00000297071FAM126Achr723023563-TRA2Achr723547154-0.0061463180.9938537
ENST00000409923ENST00000392502FAM126Achr723023563-TRA2Achr723547154-0.0060587420.9939413
ENST00000409923ENST00000538367FAM126Achr723023563-TRA2Achr723547154-0.009043410.9909566
ENST00000409763ENST00000297071FAM126Achr723023563-TRA2Achr723547154-0.0059948480.99400514
ENST00000409763ENST00000392502FAM126Achr723023563-TRA2Achr723547154-0.0072985450.9927014
ENST00000409763ENST00000538367FAM126Achr723023563-TRA2Achr723547154-0.0088844670.99111557

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Fusion Genomic Features for FAM126A-TRA2A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for FAM126A-TRA2A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:23023563/chr7:23547154)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FAM126A

Q9BYI3

.
FUNCTION: Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane (PubMed:26571211). The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (PubMed:26571211). FAM126A plays a key role in oligodendrocytes formation, a cell type with expanded plasma membrane that requires generation of PtdIns(4)P (PubMed:26571211). Its role in oligodendrocytes formation probably explains its importance in myelination of the central and peripheral nervous system (PubMed:26571211, PubMed:16951682). May also have a role in the beta-catenin/Lef signaling pathway (Probable). {ECO:0000269|PubMed:16951682, ECO:0000269|PubMed:26571211, ECO:0000305|PubMed:10910037}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTRA2Achr7:23023563chr7:23547154ENST0000029707138226_282175283.0Compositional biasNote=Arg/Ser-rich (RS2 domain)
TgeneTRA2Achr7:23023563chr7:23547154ENST0000029707138198_225175283.0RegionNote=Linker

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTRA2Achr7:23023563chr7:23547154ENST000002970713830_112175283.0Compositional biasNote=Arg/Ser-rich (RS1 domain)
TgeneTRA2Achr7:23023563chr7:23547154ENST0000029707138119_197175283.0DomainRRM


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Fusion Gene Sequence for FAM126A-TRA2A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>28441_28441_1_FAM126A-TRA2A_FAM126A_chr7_23023563_ENST00000409763_TRA2A_chr7_23547154_ENST00000297071_length(transcript)=1434nt_BP=331nt
GGGGGAAGATGGCTCACCGGGACCCGTTCTGCTAGGAAGAAGGGGAGCAGGTGGTGCTGCTACTCGGGAGGAAGCAGAGCAGCCTCCGTC
GCTGTCGCTGAGAGCCTCACGAGTCGAGGTCCTGCAGGTGGAGCTCCGGCAGCCGCCCTGGTTGAAGGTTTAGAACAGATGTGGAAAAAT
GTTTACTTCAGAGAAAGGGGTTGTGGAGGAATGGTTGTCAGAGTTTAAGACATTACCAGAAACATCTTTACCAAATTATGCCACAAATTT
GAAAGACAAGAGTTCTTTAGTTTCATCTCTCTATAAAGTTATCCAGGAGCCACAAAGTGAGGCTATGGAAAGGGCAAATGGAATGGAGCT
GGATGGTAGAAGAATTCGGGTGGATTATTCTATAACCAAGAGAGCGCACACACCAACACCAGGCATCTACATGGGCAGACCAACTCATAG
TGGTGGGGGTGGTGGAGGAGGCGGCGGCGGTGGAGGTGGAGGTGGTGGCAGACGTCGAGATTCTTACTATGATAGAGGATATGATCGTGG
GTATGACAGATATGAAGACTATGATTACCGATACAGAAGACGATCACCTTCTCCTTATTATAGTCGATATAGATCACGATCAAGATCTCG
TTCCTACAGCCCAAGACGCTATTGATAACGGAATGGTTGCAATTAAGGACATTTTTTTTCCTCTTTTTTTTTTTTTTTTTTTTAATTCTG
AGATTTCCCCAAGCTGTGGATTCTTCCTACTCCTTAAGAAAAAAACTTTGGTTTATTTAGCATCTACACTTTTGTCAGTTGTGTTGCTGT
TTTCCACCCATTTTATTATACTCTTAAAAGATGTAATTGTTGTCATTTTGAACAGTTAAACATCTTGAGTATAAAAAGAACCCCAATGTT
ATGTTATGCTTTGTAAATTTTTTTTTTTGCTTTTACCTAGATAAACTTCTAGCTAATCAAATAAGGAAAGAAACTGTCTTTTTAAAGCTT
CTTTTGTGTTAGATACTGTATTAGAGATCTGCATTTATCATGAGTTCCTTTTTTTTTTTAACTTTATTTTTGGGAAAGTAACACATGAAG
TAGTTCAGTCATGTCAGGTTTGTCTGGGGTGGAATGGAACAGTCAGGTAGTTGAAAGTTTTTTTTTAGAGATGAAAAGCTTGTGAACTCC
TGTAAAACATGCTGTATTTGAAATACATCTGTTAAAACTTAAAAACTAAAGTGTGATTTTTTTTGTTGTTGTTAAGTTTATTGAAGTTTA
TTCCCTTAATCAGTGAAGGACAACCCTTATTTATTACCTAGAGCAGTTGTATAATTCGCTGTTAGAAATTTTGGTATTGGGACAGTGGAT

>28441_28441_1_FAM126A-TRA2A_FAM126A_chr7_23023563_ENST00000409763_TRA2A_chr7_23547154_ENST00000297071_length(amino acids)=158AA_BP=51
MFTSEKGVVEEWLSEFKTLPETSLPNYATNLKDKSSLVSSLYKVIQEPQSEAMERANGMELDGRRIRVDYSITKRAHTPTPGIYMGRPTH

--------------------------------------------------------------
>28441_28441_2_FAM126A-TRA2A_FAM126A_chr7_23023563_ENST00000409763_TRA2A_chr7_23547154_ENST00000392502_length(transcript)=1061nt_BP=331nt
GGGGGAAGATGGCTCACCGGGACCCGTTCTGCTAGGAAGAAGGGGAGCAGGTGGTGCTGCTACTCGGGAGGAAGCAGAGCAGCCTCCGTC
GCTGTCGCTGAGAGCCTCACGAGTCGAGGTCCTGCAGGTGGAGCTCCGGCAGCCGCCCTGGTTGAAGGTTTAGAACAGATGTGGAAAAAT
GTTTACTTCAGAGAAAGGGGTTGTGGAGGAATGGTTGTCAGAGTTTAAGACATTACCAGAAACATCTTTACCAAATTATGCCACAAATTT
GAAAGACAAGAGTTCTTTAGTTTCATCTCTCTATAAAGTTATCCAGGAGCCACAAAGTGAGGCTATGGAAAGGGCAAATGGAATGGAGCT
GGATGGTAGAAGAATTCGGGTGGATTATTCTATAACCAAGAGAGCGCACACACCAACACCAGGCATCTACATGGGCAGACCAACTCATAG
TGGTGGGGGTGGTGGAGGAGGCGGCGGCGGTGGAGGTGGAGGTGGTGGCAGACGTCGAGATTCTTACTATGATAGAGGATATGATCGTGG
GTATGACAGATATGAAGACTATGATTACCGATACAGACGATCACCTTCTCCTTATTATAGTCGATATAGATCACGATCAAGATCTCGTTC
CTACAGCCCAAGACGCTATTGATAACGGAATGGTTGCAATTAAGGACATTTTTTTTCCTCTTTTTTTTTTTTTTTTTTTTAATTCTGAGA
TTTCCCCAAGCTGTGGATTCTTCCTACTCCTTAAGAAAAAAACTTTGGTTTATTTAGCATCTACACTTTTGTCAGTTGTGTTGCTGTTTT
CCACCCATTTTATTATACTCTTAAAAGATGTAATTGTTGTCATTTTGAACAGTTAAACATCTTGAGTATAAAAAGAACCCCAATGTTATG
TTATGCTTTGTAAATTTTTTTTTTTGCTTTTACCTAGATAAACTTCTAGCTAATCAAATAAGGAAAGAAACTGTCTTTTTAAAGCTTCTT

>28441_28441_2_FAM126A-TRA2A_FAM126A_chr7_23023563_ENST00000409763_TRA2A_chr7_23547154_ENST00000392502_length(amino acids)=157AA_BP=51
MFTSEKGVVEEWLSEFKTLPETSLPNYATNLKDKSSLVSSLYKVIQEPQSEAMERANGMELDGRRIRVDYSITKRAHTPTPGIYMGRPTH

--------------------------------------------------------------
>28441_28441_3_FAM126A-TRA2A_FAM126A_chr7_23023563_ENST00000409763_TRA2A_chr7_23547154_ENST00000538367_length(transcript)=755nt_BP=331nt
GGGGGAAGATGGCTCACCGGGACCCGTTCTGCTAGGAAGAAGGGGAGCAGGTGGTGCTGCTACTCGGGAGGAAGCAGAGCAGCCTCCGTC
GCTGTCGCTGAGAGCCTCACGAGTCGAGGTCCTGCAGGTGGAGCTCCGGCAGCCGCCCTGGTTGAAGGTTTAGAACAGATGTGGAAAAAT
GTTTACTTCAGAGAAAGGGGTTGTGGAGGAATGGTTGTCAGAGTTTAAGACATTACCAGAAACATCTTTACCAAATTATGCCACAAATTT
GAAAGACAAGAGTTCTTTAGTTTCATCTCTCTATAAAGTTATCCAGGAGCCACAAAGTGAGGCTATGGAAAGGGCAAATGGAATGGAGCT
GGATGGTAGAAGAATTCGGGTGGATTATTCTATAACCAAGAGAGCGCACACACCAACACCAGGCATCTACATGGGCAGACCAACTCATAG
TGGTGGGGGTGGTGGAGGAGGCGGCGGCGGTGGAGGTGGAGGTGGTGGCAGACGTCGAGATTCTTACTATGATAGAGGATATGATCGTGG
GTATGACAGATATGAAGACTATGATTACCGATACAGAAGACGATCACCTTCTCCTTATTATAGTCGATATAGATCACGATCAAGATCTCG
TTCCTACAGCCCAAGACGCTATTGATAACGGAATGGTTGCAATTAAGGACATTTTTTTTCCTCTTTTTTTTTTTTTTTTTTTTAATTCTG

>28441_28441_3_FAM126A-TRA2A_FAM126A_chr7_23023563_ENST00000409763_TRA2A_chr7_23547154_ENST00000538367_length(amino acids)=158AA_BP=51
MFTSEKGVVEEWLSEFKTLPETSLPNYATNLKDKSSLVSSLYKVIQEPQSEAMERANGMELDGRRIRVDYSITKRAHTPTPGIYMGRPTH

--------------------------------------------------------------
>28441_28441_4_FAM126A-TRA2A_FAM126A_chr7_23023563_ENST00000409923_TRA2A_chr7_23547154_ENST00000297071_length(transcript)=1444nt_BP=341nt
AGTGAGAGGAGGGGGAAGATGGCTCACCGGGACCCGTTCTGCTAGGAAGAAGGGGAGCAGGTGGTGCTGCTACTCGGGAGGAAGCAGAGC
AGCCTCCGTCGCTGTCGCTGAGAGCCTCACGAGTCGAGGTCCTGCAGGTGGAGCTCCGGCAGCCGCCCTGGTTGAAGGTTTAGAACAGAT
GTGGAAAAATGTTTACTTCAGAGAAAGGGGTTGTGGAGGAATGGTTGTCAGAGTTTAAGACATTACCAGAAACATCTTTACCAAATTATG
CCACAAATTTGAAAGACAAGAGTTCTTTAGTTTCATCTCTCTATAAAGTTATCCAGGAGCCACAAAGTGAGGCTATGGAAAGGGCAAATG
GAATGGAGCTGGATGGTAGAAGAATTCGGGTGGATTATTCTATAACCAAGAGAGCGCACACACCAACACCAGGCATCTACATGGGCAGAC
CAACTCATAGTGGTGGGGGTGGTGGAGGAGGCGGCGGCGGTGGAGGTGGAGGTGGTGGCAGACGTCGAGATTCTTACTATGATAGAGGAT
ATGATCGTGGGTATGACAGATATGAAGACTATGATTACCGATACAGAAGACGATCACCTTCTCCTTATTATAGTCGATATAGATCACGAT
CAAGATCTCGTTCCTACAGCCCAAGACGCTATTGATAACGGAATGGTTGCAATTAAGGACATTTTTTTTCCTCTTTTTTTTTTTTTTTTT
TTTAATTCTGAGATTTCCCCAAGCTGTGGATTCTTCCTACTCCTTAAGAAAAAAACTTTGGTTTATTTAGCATCTACACTTTTGTCAGTT
GTGTTGCTGTTTTCCACCCATTTTATTATACTCTTAAAAGATGTAATTGTTGTCATTTTGAACAGTTAAACATCTTGAGTATAAAAAGAA
CCCCAATGTTATGTTATGCTTTGTAAATTTTTTTTTTTGCTTTTACCTAGATAAACTTCTAGCTAATCAAATAAGGAAAGAAACTGTCTT
TTTAAAGCTTCTTTTGTGTTAGATACTGTATTAGAGATCTGCATTTATCATGAGTTCCTTTTTTTTTTTAACTTTATTTTTGGGAAAGTA
ACACATGAAGTAGTTCAGTCATGTCAGGTTTGTCTGGGGTGGAATGGAACAGTCAGGTAGTTGAAAGTTTTTTTTTAGAGATGAAAAGCT
TGTGAACTCCTGTAAAACATGCTGTATTTGAAATACATCTGTTAAAACTTAAAAACTAAAGTGTGATTTTTTTTGTTGTTGTTAAGTTTA
TTGAAGTTTATTCCCTTAATCAGTGAAGGACAACCCTTATTTATTACCTAGAGCAGTTGTATAATTCGCTGTTAGAAATTTTGGTATTGG
GACAGTGGATAAGCAGGTTATCACATAGCATAGAATTCTTAAAAGATACATGTGGGGAAAAGTAGTCTCAAATAAAAGCTAATTTCTTTG

>28441_28441_4_FAM126A-TRA2A_FAM126A_chr7_23023563_ENST00000409923_TRA2A_chr7_23547154_ENST00000297071_length(amino acids)=158AA_BP=51
MFTSEKGVVEEWLSEFKTLPETSLPNYATNLKDKSSLVSSLYKVIQEPQSEAMERANGMELDGRRIRVDYSITKRAHTPTPGIYMGRPTH

--------------------------------------------------------------
>28441_28441_5_FAM126A-TRA2A_FAM126A_chr7_23023563_ENST00000409923_TRA2A_chr7_23547154_ENST00000392502_length(transcript)=1071nt_BP=341nt
AGTGAGAGGAGGGGGAAGATGGCTCACCGGGACCCGTTCTGCTAGGAAGAAGGGGAGCAGGTGGTGCTGCTACTCGGGAGGAAGCAGAGC
AGCCTCCGTCGCTGTCGCTGAGAGCCTCACGAGTCGAGGTCCTGCAGGTGGAGCTCCGGCAGCCGCCCTGGTTGAAGGTTTAGAACAGAT
GTGGAAAAATGTTTACTTCAGAGAAAGGGGTTGTGGAGGAATGGTTGTCAGAGTTTAAGACATTACCAGAAACATCTTTACCAAATTATG
CCACAAATTTGAAAGACAAGAGTTCTTTAGTTTCATCTCTCTATAAAGTTATCCAGGAGCCACAAAGTGAGGCTATGGAAAGGGCAAATG
GAATGGAGCTGGATGGTAGAAGAATTCGGGTGGATTATTCTATAACCAAGAGAGCGCACACACCAACACCAGGCATCTACATGGGCAGAC
CAACTCATAGTGGTGGGGGTGGTGGAGGAGGCGGCGGCGGTGGAGGTGGAGGTGGTGGCAGACGTCGAGATTCTTACTATGATAGAGGAT
ATGATCGTGGGTATGACAGATATGAAGACTATGATTACCGATACAGACGATCACCTTCTCCTTATTATAGTCGATATAGATCACGATCAA
GATCTCGTTCCTACAGCCCAAGACGCTATTGATAACGGAATGGTTGCAATTAAGGACATTTTTTTTCCTCTTTTTTTTTTTTTTTTTTTT
AATTCTGAGATTTCCCCAAGCTGTGGATTCTTCCTACTCCTTAAGAAAAAAACTTTGGTTTATTTAGCATCTACACTTTTGTCAGTTGTG
TTGCTGTTTTCCACCCATTTTATTATACTCTTAAAAGATGTAATTGTTGTCATTTTGAACAGTTAAACATCTTGAGTATAAAAAGAACCC
CAATGTTATGTTATGCTTTGTAAATTTTTTTTTTTGCTTTTACCTAGATAAACTTCTAGCTAATCAAATAAGGAAAGAAACTGTCTTTTT

>28441_28441_5_FAM126A-TRA2A_FAM126A_chr7_23023563_ENST00000409923_TRA2A_chr7_23547154_ENST00000392502_length(amino acids)=157AA_BP=51
MFTSEKGVVEEWLSEFKTLPETSLPNYATNLKDKSSLVSSLYKVIQEPQSEAMERANGMELDGRRIRVDYSITKRAHTPTPGIYMGRPTH

--------------------------------------------------------------
>28441_28441_6_FAM126A-TRA2A_FAM126A_chr7_23023563_ENST00000409923_TRA2A_chr7_23547154_ENST00000538367_length(transcript)=765nt_BP=341nt
AGTGAGAGGAGGGGGAAGATGGCTCACCGGGACCCGTTCTGCTAGGAAGAAGGGGAGCAGGTGGTGCTGCTACTCGGGAGGAAGCAGAGC
AGCCTCCGTCGCTGTCGCTGAGAGCCTCACGAGTCGAGGTCCTGCAGGTGGAGCTCCGGCAGCCGCCCTGGTTGAAGGTTTAGAACAGAT
GTGGAAAAATGTTTACTTCAGAGAAAGGGGTTGTGGAGGAATGGTTGTCAGAGTTTAAGACATTACCAGAAACATCTTTACCAAATTATG
CCACAAATTTGAAAGACAAGAGTTCTTTAGTTTCATCTCTCTATAAAGTTATCCAGGAGCCACAAAGTGAGGCTATGGAAAGGGCAAATG
GAATGGAGCTGGATGGTAGAAGAATTCGGGTGGATTATTCTATAACCAAGAGAGCGCACACACCAACACCAGGCATCTACATGGGCAGAC
CAACTCATAGTGGTGGGGGTGGTGGAGGAGGCGGCGGCGGTGGAGGTGGAGGTGGTGGCAGACGTCGAGATTCTTACTATGATAGAGGAT
ATGATCGTGGGTATGACAGATATGAAGACTATGATTACCGATACAGAAGACGATCACCTTCTCCTTATTATAGTCGATATAGATCACGAT
CAAGATCTCGTTCCTACAGCCCAAGACGCTATTGATAACGGAATGGTTGCAATTAAGGACATTTTTTTTCCTCTTTTTTTTTTTTTTTTT

>28441_28441_6_FAM126A-TRA2A_FAM126A_chr7_23023563_ENST00000409923_TRA2A_chr7_23547154_ENST00000538367_length(amino acids)=158AA_BP=51
MFTSEKGVVEEWLSEFKTLPETSLPNYATNLKDKSSLVSSLYKVIQEPQSEAMERANGMELDGRRIRVDYSITKRAHTPTPGIYMGRPTH

--------------------------------------------------------------
>28441_28441_7_FAM126A-TRA2A_FAM126A_chr7_23023563_ENST00000432176_TRA2A_chr7_23547154_ENST00000297071_length(transcript)=1489nt_BP=386nt
GAGAGGCTGGCGGCAGTGGTGGCTCTCCCGGCTGGGTTGTCAGTCAGTGAGAGGAGGGGGAAGATGGCTCACCGGGACCCGTTCTGCTAG
GAAGAAGGGGAGCAGGTGGTGCTGCTACTCGGGAGGAAGCAGAGCAGCCTCCGTCGCTGTCGCTGAGAGCCTCACGAGTCGAGGTCCTGC
AGGTGGAGCTCCGGCAGCCGCCCTGGTTGAAGGTTTAGAACAGATGTGGAAAAATGTTTACTTCAGAGAAAGGGGTTGTGGAGGAATGGT
TGTCAGAGTTTAAGACATTACCAGAAACATCTTTACCAAATTATGCCACAAATTTGAAAGACAAGAGTTCTTTAGTTTCATCTCTCTATA
AAGTTATCCAGGAGCCACAAAGTGAGGCTATGGAAAGGGCAAATGGAATGGAGCTGGATGGTAGAAGAATTCGGGTGGATTATTCTATAA
CCAAGAGAGCGCACACACCAACACCAGGCATCTACATGGGCAGACCAACTCATAGTGGTGGGGGTGGTGGAGGAGGCGGCGGCGGTGGAG
GTGGAGGTGGTGGCAGACGTCGAGATTCTTACTATGATAGAGGATATGATCGTGGGTATGACAGATATGAAGACTATGATTACCGATACA
GAAGACGATCACCTTCTCCTTATTATAGTCGATATAGATCACGATCAAGATCTCGTTCCTACAGCCCAAGACGCTATTGATAACGGAATG
GTTGCAATTAAGGACATTTTTTTTCCTCTTTTTTTTTTTTTTTTTTTTAATTCTGAGATTTCCCCAAGCTGTGGATTCTTCCTACTCCTT
AAGAAAAAAACTTTGGTTTATTTAGCATCTACACTTTTGTCAGTTGTGTTGCTGTTTTCCACCCATTTTATTATACTCTTAAAAGATGTA
ATTGTTGTCATTTTGAACAGTTAAACATCTTGAGTATAAAAAGAACCCCAATGTTATGTTATGCTTTGTAAATTTTTTTTTTTGCTTTTA
CCTAGATAAACTTCTAGCTAATCAAATAAGGAAAGAAACTGTCTTTTTAAAGCTTCTTTTGTGTTAGATACTGTATTAGAGATCTGCATT
TATCATGAGTTCCTTTTTTTTTTTAACTTTATTTTTGGGAAAGTAACACATGAAGTAGTTCAGTCATGTCAGGTTTGTCTGGGGTGGAAT
GGAACAGTCAGGTAGTTGAAAGTTTTTTTTTAGAGATGAAAAGCTTGTGAACTCCTGTAAAACATGCTGTATTTGAAATACATCTGTTAA
AACTTAAAAACTAAAGTGTGATTTTTTTTGTTGTTGTTAAGTTTATTGAAGTTTATTCCCTTAATCAGTGAAGGACAACCCTTATTTATT
ACCTAGAGCAGTTGTATAATTCGCTGTTAGAAATTTTGGTATTGGGACAGTGGATAAGCAGGTTATCACATAGCATAGAATTCTTAAAAG

>28441_28441_7_FAM126A-TRA2A_FAM126A_chr7_23023563_ENST00000432176_TRA2A_chr7_23547154_ENST00000297071_length(amino acids)=158AA_BP=51
MFTSEKGVVEEWLSEFKTLPETSLPNYATNLKDKSSLVSSLYKVIQEPQSEAMERANGMELDGRRIRVDYSITKRAHTPTPGIYMGRPTH

--------------------------------------------------------------
>28441_28441_8_FAM126A-TRA2A_FAM126A_chr7_23023563_ENST00000432176_TRA2A_chr7_23547154_ENST00000392502_length(transcript)=1116nt_BP=386nt
GAGAGGCTGGCGGCAGTGGTGGCTCTCCCGGCTGGGTTGTCAGTCAGTGAGAGGAGGGGGAAGATGGCTCACCGGGACCCGTTCTGCTAG
GAAGAAGGGGAGCAGGTGGTGCTGCTACTCGGGAGGAAGCAGAGCAGCCTCCGTCGCTGTCGCTGAGAGCCTCACGAGTCGAGGTCCTGC
AGGTGGAGCTCCGGCAGCCGCCCTGGTTGAAGGTTTAGAACAGATGTGGAAAAATGTTTACTTCAGAGAAAGGGGTTGTGGAGGAATGGT
TGTCAGAGTTTAAGACATTACCAGAAACATCTTTACCAAATTATGCCACAAATTTGAAAGACAAGAGTTCTTTAGTTTCATCTCTCTATA
AAGTTATCCAGGAGCCACAAAGTGAGGCTATGGAAAGGGCAAATGGAATGGAGCTGGATGGTAGAAGAATTCGGGTGGATTATTCTATAA
CCAAGAGAGCGCACACACCAACACCAGGCATCTACATGGGCAGACCAACTCATAGTGGTGGGGGTGGTGGAGGAGGCGGCGGCGGTGGAG
GTGGAGGTGGTGGCAGACGTCGAGATTCTTACTATGATAGAGGATATGATCGTGGGTATGACAGATATGAAGACTATGATTACCGATACA
GACGATCACCTTCTCCTTATTATAGTCGATATAGATCACGATCAAGATCTCGTTCCTACAGCCCAAGACGCTATTGATAACGGAATGGTT
GCAATTAAGGACATTTTTTTTCCTCTTTTTTTTTTTTTTTTTTTTAATTCTGAGATTTCCCCAAGCTGTGGATTCTTCCTACTCCTTAAG
AAAAAAACTTTGGTTTATTTAGCATCTACACTTTTGTCAGTTGTGTTGCTGTTTTCCACCCATTTTATTATACTCTTAAAAGATGTAATT
GTTGTCATTTTGAACAGTTAAACATCTTGAGTATAAAAAGAACCCCAATGTTATGTTATGCTTTGTAAATTTTTTTTTTTGCTTTTACCT
AGATAAACTTCTAGCTAATCAAATAAGGAAAGAAACTGTCTTTTTAAAGCTTCTTTTGTGTTAGATACTGTATTAGAGATCTGCATTTAT

>28441_28441_8_FAM126A-TRA2A_FAM126A_chr7_23023563_ENST00000432176_TRA2A_chr7_23547154_ENST00000392502_length(amino acids)=157AA_BP=51
MFTSEKGVVEEWLSEFKTLPETSLPNYATNLKDKSSLVSSLYKVIQEPQSEAMERANGMELDGRRIRVDYSITKRAHTPTPGIYMGRPTH

--------------------------------------------------------------
>28441_28441_9_FAM126A-TRA2A_FAM126A_chr7_23023563_ENST00000432176_TRA2A_chr7_23547154_ENST00000538367_length(transcript)=810nt_BP=386nt
GAGAGGCTGGCGGCAGTGGTGGCTCTCCCGGCTGGGTTGTCAGTCAGTGAGAGGAGGGGGAAGATGGCTCACCGGGACCCGTTCTGCTAG
GAAGAAGGGGAGCAGGTGGTGCTGCTACTCGGGAGGAAGCAGAGCAGCCTCCGTCGCTGTCGCTGAGAGCCTCACGAGTCGAGGTCCTGC
AGGTGGAGCTCCGGCAGCCGCCCTGGTTGAAGGTTTAGAACAGATGTGGAAAAATGTTTACTTCAGAGAAAGGGGTTGTGGAGGAATGGT
TGTCAGAGTTTAAGACATTACCAGAAACATCTTTACCAAATTATGCCACAAATTTGAAAGACAAGAGTTCTTTAGTTTCATCTCTCTATA
AAGTTATCCAGGAGCCACAAAGTGAGGCTATGGAAAGGGCAAATGGAATGGAGCTGGATGGTAGAAGAATTCGGGTGGATTATTCTATAA
CCAAGAGAGCGCACACACCAACACCAGGCATCTACATGGGCAGACCAACTCATAGTGGTGGGGGTGGTGGAGGAGGCGGCGGCGGTGGAG
GTGGAGGTGGTGGCAGACGTCGAGATTCTTACTATGATAGAGGATATGATCGTGGGTATGACAGATATGAAGACTATGATTACCGATACA
GAAGACGATCACCTTCTCCTTATTATAGTCGATATAGATCACGATCAAGATCTCGTTCCTACAGCCCAAGACGCTATTGATAACGGAATG
GTTGCAATTAAGGACATTTTTTTTCCTCTTTTTTTTTTTTTTTTTTTTAATTCTGAGATTTCCCCAAGCTGTGGATTCTTCCTACTCCTT

>28441_28441_9_FAM126A-TRA2A_FAM126A_chr7_23023563_ENST00000432176_TRA2A_chr7_23547154_ENST00000538367_length(amino acids)=158AA_BP=51
MFTSEKGVVEEWLSEFKTLPETSLPNYATNLKDKSSLVSSLYKVIQEPQSEAMERANGMELDGRRIRVDYSITKRAHTPTPGIYMGRPTH

--------------------------------------------------------------

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Fusion Gene PPI Analysis for FAM126A-TRA2A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FAM126A-TRA2A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FAM126A-TRA2A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource