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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FAM131A-PIK3R4 (FusionGDB2 ID:28484)

Fusion Gene Summary for FAM131A-PIK3R4

check button Fusion gene summary
Fusion gene informationFusion gene name: FAM131A-PIK3R4
Fusion gene ID: 28484
HgeneTgene
Gene symbol

FAM131A

PIK3R4

Gene ID

131408

30849

Gene namefamily with sequence similarity 131 member Aphosphoinositide-3-kinase regulatory subunit 4
SynonymsC3orf40|FLAT715|PRO1378VPS15|p150
Cytomap

3q27.1

3q22.1

Type of geneprotein-codingprotein-coding
Descriptionprotein FAM131Aphosphoinositide 3-kinase regulatory subunit 4PI3-kinase p150 subunitPI3-kinase regulatory subunit 4phosphatidylinositol 3-kinase-associated p150phosphoinositide 3-kinase adaptor proteinphosphoinositide-3-kinase, regulatory subunit 4, p150
Modification date2020031320200313
UniProtAcc

Q6UXB0

.
Ensembl transtripts involved in fusion geneENST00000310585, ENST00000340957, 
ENST00000383847, ENST00000418281, 
ENST00000450976, ENST00000453072, 
ENST00000497070, 		ENST00000512677, 
ENST00000356763, 
Fusion gene scores* DoF score3 X 4 X 3=363 X 4 X 2=24
# samples 34
** MAII scorelog2(3/36*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: FAM131A [Title/Abstract] AND PIK3R4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFAM131A(184060648)-PIK3R4(130454846), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePIK3R4

GO:0043552

positive regulation of phosphatidylinositol 3-kinase activity

21062745


check buttonFusion gene breakpoints across FAM131A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PIK3R4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-55-8091-01AFAM131Achr3

184060648

+PIK3R4chr3

130454846

-


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Fusion Gene ORF analysis for FAM131A-PIK3R4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000310585ENST00000512677FAM131Achr3

184060648

+PIK3R4chr3

130454846

-
5CDS-intronENST00000340957ENST00000512677FAM131Achr3

184060648

+PIK3R4chr3

130454846

-
5CDS-intronENST00000383847ENST00000512677FAM131Achr3

184060648

+PIK3R4chr3

130454846

-
5CDS-intronENST00000418281ENST00000512677FAM131Achr3

184060648

+PIK3R4chr3

130454846

-
5CDS-intronENST00000450976ENST00000512677FAM131Achr3

184060648

+PIK3R4chr3

130454846

-
5CDS-intronENST00000453072ENST00000512677FAM131Achr3

184060648

+PIK3R4chr3

130454846

-
In-frameENST00000310585ENST00000356763FAM131Achr3

184060648

+PIK3R4chr3

130454846

-
In-frameENST00000340957ENST00000356763FAM131Achr3

184060648

+PIK3R4chr3

130454846

-
In-frameENST00000383847ENST00000356763FAM131Achr3

184060648

+PIK3R4chr3

130454846

-
In-frameENST00000418281ENST00000356763FAM131Achr3

184060648

+PIK3R4chr3

130454846

-
In-frameENST00000450976ENST00000356763FAM131Achr3

184060648

+PIK3R4chr3

130454846

-
In-frameENST00000453072ENST00000356763FAM131Achr3

184060648

+PIK3R4chr3

130454846

-
intron-3CDSENST00000497070ENST00000356763FAM131Achr3

184060648

+PIK3R4chr3

130454846

-
intron-intronENST00000497070ENST00000512677FAM131Achr3

184060648

+PIK3R4chr3

130454846

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000450976FAM131Achr3184060648+ENST00000356763PIK3R4chr3130454846-452079610541391344
ENST00000418281FAM131Achr3184060648+ENST00000356763PIK3R4chr3130454846-428055610238991265
ENST00000340957FAM131Achr3184060648+ENST00000356763PIK3R4chr3130454846-436664223339851250
ENST00000383847FAM131Achr3184060648+ENST00000356763PIK3R4chr3130454846-452880415241471331
ENST00000453072FAM131Achr3184060648+ENST00000356763PIK3R4chr3130454846-42705463838891283
ENST00000310585FAM131Achr3184060648+ENST00000356763PIK3R4chr3130454846-56201896136452391291

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000450976ENST00000356763FAM131Achr3184060648+PIK3R4chr3130454846-0.0002901680.9997098
ENST00000418281ENST00000356763FAM131Achr3184060648+PIK3R4chr3130454846-0.0002419630.99975806
ENST00000340957ENST00000356763FAM131Achr3184060648+PIK3R4chr3130454846-0.0002476150.99975234
ENST00000383847ENST00000356763FAM131Achr3184060648+PIK3R4chr3130454846-0.0002328320.9997671
ENST00000453072ENST00000356763FAM131Achr3184060648+PIK3R4chr3130454846-0.0002341290.99976593
ENST00000310585ENST00000356763FAM131Achr3184060648+PIK3R4chr3130454846-0.0009414690.99905854

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Fusion Genomic Features for FAM131A-PIK3R4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for FAM131A-PIK3R4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:184060648/chr3:130454846)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FAM131A

Q6UXB0

.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePIK3R4chr3:184060648chr3:130454846ENST00000356763120781_7842441359.0Compositional biasNote=Poly-Glu
TgenePIK3R4chr3:184060648chr3:130454846ENST00000356763120974_9772441359.0Compositional biasNote=Poly-Pro
TgenePIK3R4chr3:184060648chr3:130454846ENST000003567631201040_10792441359.0RepeatNote=WD 2
TgenePIK3R4chr3:184060648chr3:130454846ENST000003567631201093_11342441359.0RepeatNote=WD 3
TgenePIK3R4chr3:184060648chr3:130454846ENST000003567631201139_11782441359.0RepeatNote=WD 4
TgenePIK3R4chr3:184060648chr3:130454846ENST000003567631201182_12232441359.0RepeatNote=WD 5
TgenePIK3R4chr3:184060648chr3:130454846ENST000003567631201237_12782441359.0RepeatNote=WD 6
TgenePIK3R4chr3:184060648chr3:130454846ENST000003567631201327_13582441359.0RepeatNote=WD 7
TgenePIK3R4chr3:184060648chr3:130454846ENST00000356763120413_4502441359.0RepeatNote=HEAT 1
TgenePIK3R4chr3:184060648chr3:130454846ENST00000356763120458_4952441359.0RepeatNote=HEAT 2
TgenePIK3R4chr3:184060648chr3:130454846ENST00000356763120572_6102441359.0RepeatNote=HEAT 3
TgenePIK3R4chr3:184060648chr3:130454846ENST00000356763120991_10302441359.0RepeatNote=WD 1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePIK3R4chr3:184060648chr3:130454846ENST0000035676312026_3242441359.0DomainProtein kinase
TgenePIK3R4chr3:184060648chr3:130454846ENST0000035676312032_402441359.0Nucleotide bindingATP


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Fusion Gene Sequence for FAM131A-PIK3R4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>28484_28484_1_FAM131A-PIK3R4_FAM131A_chr3_184060648_ENST00000310585_PIK3R4_chr3_130454846_ENST00000356763_length(transcript)=5620nt_BP=1896nt
GAACGTGCCACCATGCCCAGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCGTGACCT
CATGATCCGCTCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGACGCCTGGCCAGCCTATGCATTTTTAAGAAATTA
TTCTGTATTAGGTGCTGTGCTAAACATTGGGCACTACAGTGACCAAAACAGACTGAATTCCCCAAGAGCCAAAGACCAGTGAGGGAGACC
AACAAGAAACAGGAAATGCAAAAGAGACCATTATTACTCACTATGACTAAGGGCCACAAATGGGGTACGTTGATGGAGAGTGATTTGTTA
AGAGACTACAGAGGGAGGACAGACTACCAAGAGGGGGGCCAGGAAAGCTCCTCTGACGAGGTGGTATTTCAGCCCAAACTGGAAGAATGA
GAAAGAGCTAGCCAGCCATCAGAATAGTCCAGAAGAGATGGGGAGCACTACACTCACTACACTTTGGCCTGAGAAAATAGCATGGGATTG
GAGGAGGCTGGGGGAACACCACTTCTGCCGACCTGGGCAGGAGGCATTGAGGGCTTGAGAAAGGGCAATGGCAGTAGCAGTAGAAAGGAC
AGGGTAGGAGCAGGGACTTTGCAGGTGGAATCATTAGGTCTTATCAACAGATATGGGCAAGCAAAGCCAGGGGAGAATTGATGGTAATGC
TGAGGTTTGGAGCCAGGCTAGATGGGACAGTGGTGGGTGATGCAAAGGAAAGAGGTCAGGAAGCAGGGCCAGACGTGGGGAGAAGGTGTG
GGGGTTTGGTTTCCATCTTGCCGAGTCTGCCGGAATGTGGATGGGAAGACCAAGAGGAGGAGCAAGGGGCAGAGGGGAAGGGAATCTTAA
AGAAGTCCTGGATGCCACACTCTTCTTCCTTCCTCCTCTTCCCTCTCCTCAGAGGTCTCACTCGTGGTTCTTCATTTCCTGCCCTGCCTC
CATCTCCTCTGGGTGCTGGGAAAGTGGAGGATTAGCTGAAGTTTTGCTTCTCGGGGCCTGTCTGAATCTCCATTGCTTTCTGGGAGGACA
TAATTCACCTGTCCTAGCTTCTTATCATCTTACATTTCCCTGTAGCCACTGGGACATATGTGGTGTTCCTTCCTAGCTCCTGTCTCCTCC
TCATGCCTTTGCTGGGTATGGGCATGTTAGGGGGAAGGTCATTGCTGTCAGAGGGGCACTGACTTTCTAATGGTGTTACCCAAGGTGAAT
GTTGGAGACACAGTCGCGATGCTGCCCAAGTCCCGGCGAGCCCTAACTATCCAGGAGATCGCTGCGCTGGCCAGGTCCTCCCTGCATGGT
ATGCAGCCCCTCCCATGTTTCTGGCCACTTTGTCCTTTCTCCTCCCGTTTGCACATCCCTTTGGAACTGTTTCCTGTGAGTACATGCTGG
GGTCTCCCCTTTCTTCCCTTGCTCAGGTGAATCTCAGCCCCTTCTCCCACCCAAAGGTTCACATGGATCCTAACTACTGCCACCCTTCCA
CCTCCCTGCACCTGTGCTCCCTGGCCTGGTCCTTTACCAGGCTTCTCCACCCTCCCCTATCTCCAGGTATTTCCCAGGTGGTGAAGGACC
ACGTGACCAAGCCTACCGCCATGGCCCAGGGCCGAGTGGCTCACCTCATTGAGTGGAAGGGCTGGAGCAAGCCGAGTGACTCACCTGCTG
CCCTGGAATCAGCCTTTTCCTCCTATTCAGACCTCAGCGAGGGCGAACAAGAGGCTCGCTTTGCAGCAGGAGTGGCTGAGCAGTTTGCCA
TCGCGGAAGCCAAGCTCCGAGCATGGTCTTCGGTGGATGGCGAGGACTCCACTGATGACTCCTATGATGAGGACTTTGCTGGGGGAATGG
ACACAGGTTGTGTGATAGCTGAGCTTTTTACAGAAGGTGTACCATTATTTGATCTCTCTCAACTTTTGGCTTATAGAAATGGACATTTTT
TCCCTGAACAAGTGCTAAATAAAATTGAAGATCACAGTATCAGAGAATTGGTAACTCAGATGATTCACCGTGAGCCAGATAAACGTTTAG
AGGCAGAAGATTACTTAAAACAGCAGCGTGGCAATGCCTTTCCTGAAATATTTTACACTTTTCTTCAGCCCTACATGGCCCAGTTTGCCA
AGGAAACGTTTCTTTCTGCAGATGAGCGTATTCTGGTTATACGGAAGGATTTGGGCAACATTATTCACAATCTCTGTGGACATGATCTGC
CAGAAAAAGCCGAAGGAGAGCCTAAGGAAAATGGGCTGGTTATCTTGGTATCTGTTATAACATCCTGCCTACAGACCCTTAAATACTGTG
ATTCCAAACTAGCTGCTTTGGAACTGATTCTTCATTTGGCTCCAAGATTAAGTGTTGAAATCCTTTTGGATCGTATTACTCCATATCTTT
TGCATTTCAGCAATGACTCTGTTCCTAGGGTGAGGGCTGAAGCCTTGAGGACGTTGACCAAAGTTCTTGCTCTCGTCAAAGAGGTTCCTC
GTAATGATATCAATATTTATCCGGAATACATTCTGCCAGGCATAGCCCACTTAGCCCAAGATGATGCTACTATCGTTAGACTAGCCTATG
CTGAAAACATAGCTCTGCTGGCAGAAACAGCTCTGAGATTCCTGGAATTAGTACAGTTAAAAAATCTTAATATGGAAAATGACCCCAATA
ATGAAGAAATAGATGAGGTTACACATCCAAATGGAAATTATGACACAGAGCTCCAAGCCTTACATGAAATGGTCCAGCAGAAAGTTGTTA
CTTTGCTAAGTGACCCTGAAAATATTGTAAAACAAACCTTGATGGAAAATGGAATAACACGGCTGTGTGTATTCTTTGGACGTCAGAAAG
CCAACGATGTTTTGTTGTCCCACATGATTACTTTCCTAAATGATAAGAATGATTGGCATCTACGTGGAGCATTTTTTGATAGTATAGTTG
GTGTTGCTGCCTATGTTGGCTGGCAAAGCTCCTCAATTCTCAAGCCTCTGCTGCAACAAGGTCTTAGTGATGCTGAGGAATTTGTCATTG
TGAAAGCTCTTTATGCCCTTACTTGTATGTGCCAGTTAGGACTGCTACAAAAACCCCATGTTTACGAATTTGCCAGTGATATTGCCCCCT
TCCTGTGTCATCCCAATTTATGGATACGTTATGGTGCCGTGGGATTTATCACAGTGGTAGCTCGTCAAATAAGTACAGCTGATGTCTACT
GTAAACTGATGCCTTATCTTGACCCATATATTACCCAACCAATAATACAGATTGAAAGAAAACTTGTTCTGCTCAGTGTTTTAAAGGAAC
CAGTAAGTCGTTCTATATTTGATTATGCTTTGAGGTCTAAAGATATTACTAGCTTGTTCAGACATCTTCACATGCGTCAGAAGAAACGAA
ATGGTTCTCTTCCCGACTGCCCTCCGCCAGAGGATCCTGCCATAGCACAGCTTCTGAAGAAGTTGCTCTCACAGGGAATGACAGAGGAAG
AGGAAGACAAACTTCTGGCACTGAAAGACTTCATGATGAAATCTAATAAAGCAAAGGCCAATATAGTGGACCAGAGCCATCTTCATGATA
GTAGTCAGAAAGGTGTAATTGACTTGGCAGCTTTAGGCATAACTGGGAGACAAGTTGATCTTGTTAAAACCAAACAAGAACCAGATGACA
AACGGGCCAGAAAACATGTAAAACAAGACTCAAATGTAAATGAAGAATGGAAAAGCATGTTTGGGTCACTGGACCCACCAAACATGCCAC
AGGCCCTACCTAAAGGGAGTGATCAGGAGGTGATTCAGACTGGGAAACCTCCTCGTTCCGAGTCCTCTGCTGGCATTTGTGTCCCTTTGT
CAACTTCTTCACAGGTTCCAGAAGTGACAACTGTCCAAAATAAAAAACCAGTAATACCGGTTTTAAGTAGTACAATCTTACCATCCACCT
ATCAGATTCGAATTACAACTTGTAAAACTGAACTTCAGCAACTCATCCAGCAAAAGCGGGAGCAGTGCAATGCTGAGAGAATAGCTAAGC
AGATGATGGAAAATGCTGAATGGGAGAGTAAACCACCACCACCTGGATGGCGTCCTAAAGGGCTGTTAGTTGCCCATCTTCATGAGCATA
AATCTGCTGTGAATCGAATTAGAGTCTCTGATGAACACTCACTTTTTGCAACATGTTCAAATGATGGCACAGTGAAAATCTGGAACAGTC
AAAAGATGGAGGGGAAGACCACCACTACCAGATCTATTCTTACATACAGCCGAATTGGAGGACGAGTCAAGACGCTCACATTCTGCCAAG
GCTCCCACTATTTAGCCATAGCATCTGATAATGGTGCTGTCCAGCTTCTTGGAATTGAGGCTTCTAAGCTGCCCAAGTCTCCTAAAATCC
ATCCTCTACAAAGCAGAATTCTAGATCAGAAGGAGGACGGTTGTGTTGTGGATATGCATCACTTCAACTCTGGAGCACAGTCTGTTCTTG
CCTATGCCACTGTGAATGGCTCTCTGGTTGGCTGGGACCTTAGGTCTTCAAGCAATGCGTGGACTTTAAAGCATGATTTAAAGTCGGGCC
TCATCACTTCCTTTGCTGTGGACATCCACCAATGCTGGCTCTGCATTGGTACAAGCAGTGGTACCATGGCTTGTTGGGACATGAGGTTCC
AGTTGCCAATTTCAAGTCACTGTCATCCTTCCAGGGCTCGAATCAGACGCCTCTCAATGCACCCTCTGTATCAGTCCTGGGTGATTGCAG
CTGTTCAGGGCAACAACGAAGTGTCCATGTGGGACATGGAGACTGGTGACAGAAGATTTACTCTCTGGGCCAGCAGTGCACCACCACTTT
CTGAATTACAGCCTTCTCCTCATAGCGTCCATGGTATCTACTGTAGTCCTGCAGATGGAAATCCTATCCTACTAACAGCTGGCTCAGATA
TGAAAATAAGGTTTTGGGACTTGGCTTACCCAGAAAGGTCCTATGTTGTTGCAGGAAGTACTAGTTCCCCATCTGTGTCCTACTACAGGA
AAATAATTGAAGGCACTGAAGTTGTCCAGGAAATTCAGAATAAGCAGAAAGTAGGACCAAGTGATGACACCCCTCGAAGGGGCCCAGAGT
CCCTGCCCGTGGGACATCATGACATCATCACTGATGTCGCCACATTCCAGACCACACAGGGCTTCATCGTAACTGCTTCTAGAGATGGGA
TTGTGAAGGTGTGGAAATAAAACCTACTGATTTGTATAAATTTTAATAGTTATAAATATAATACTATAACTCGAGAAAAGGCATTTCTAG
AGAACAGATTCATTTGCTTAATTTTCAAAATTATGTCTCCATATTACTGTTTCATGACTGACTGACTAAATGACACCCAAAATGGTTAAG
ATGTACTTGACTAGTTTACTTATGCATCTCTTTGCAAGAATCAGCCAGCCAACAATGTCTGGGATTTTTATTGTATATGTTATAGAGGTG
AGAAATGTAAAATATGAAAATGAATATGTTTATTTTGTATTGAAAAAGATGGTTGAAAAGATGGTTGTAAGCTATTATAGTATAAACACA

>28484_28484_1_FAM131A-PIK3R4_FAM131A_chr3_184060648_ENST00000310585_PIK3R4_chr3_130454846_ENST00000356763_length(amino acids)=1291AA_BP=177
MFLATLSFLLPFAHPFGTVSCEYMLGSPLSSLAQVNLSPFSHPKVHMDPNYCHPSTSLHLCSLAWSFTRLLHPPLSPGISQVVKDHVTKP
TAMAQGRVAHLIEWKGWSKPSDSPAALESAFSSYSDLSEGEQEARFAAGVAEQFAIAEAKLRAWSSVDGEDSTDDSYDEDFAGGMDTGCV
IAELFTEGVPLFDLSQLLAYRNGHFFPEQVLNKIEDHSIRELVTQMIHREPDKRLEAEDYLKQQRGNAFPEIFYTFLQPYMAQFAKETFL
SADERILVIRKDLGNIIHNLCGHDLPEKAEGEPKENGLVILVSVITSCLQTLKYCDSKLAALELILHLAPRLSVEILLDRITPYLLHFSN
DSVPRVRAEALRTLTKVLALVKEVPRNDINIYPEYILPGIAHLAQDDATIVRLAYAENIALLAETALRFLELVQLKNLNMENDPNNEEID
EVTHPNGNYDTELQALHEMVQQKVVTLLSDPENIVKQTLMENGITRLCVFFGRQKANDVLLSHMITFLNDKNDWHLRGAFFDSIVGVAAY
VGWQSSSILKPLLQQGLSDAEEFVIVKALYALTCMCQLGLLQKPHVYEFASDIAPFLCHPNLWIRYGAVGFITVVARQISTADVYCKLMP
YLDPYITQPIIQIERKLVLLSVLKEPVSRSIFDYALRSKDITSLFRHLHMRQKKRNGSLPDCPPPEDPAIAQLLKKLLSQGMTEEEEDKL
LALKDFMMKSNKAKANIVDQSHLHDSSQKGVIDLAALGITGRQVDLVKTKQEPDDKRARKHVKQDSNVNEEWKSMFGSLDPPNMPQALPK
GSDQEVIQTGKPPRSESSAGICVPLSTSSQVPEVTTVQNKKPVIPVLSSTILPSTYQIRITTCKTELQQLIQQKREQCNAERIAKQMMEN
AEWESKPPPPGWRPKGLLVAHLHEHKSAVNRIRVSDEHSLFATCSNDGTVKIWNSQKMEGKTTTTRSILTYSRIGGRVKTLTFCQGSHYL
AIASDNGAVQLLGIEASKLPKSPKIHPLQSRILDQKEDGCVVDMHHFNSGAQSVLAYATVNGSLVGWDLRSSSNAWTLKHDLKSGLITSF
AVDIHQCWLCIGTSSGTMACWDMRFQLPISSHCHPSRARIRRLSMHPLYQSWVIAAVQGNNEVSMWDMETGDRRFTLWASSAPPLSELQP
SPHSVHGIYCSPADGNPILLTAGSDMKIRFWDLAYPERSYVVAGSTSSPSVSYYRKIIEGTEVVQEIQNKQKVGPSDDTPRRGPESLPVG

--------------------------------------------------------------
>28484_28484_2_FAM131A-PIK3R4_FAM131A_chr3_184060648_ENST00000340957_PIK3R4_chr3_130454846_ENST00000356763_length(transcript)=4366nt_BP=642nt
GGTTCCCTCTCCGGGGAGCGGCGGCGGACGCGCGGCTCCCACCCCTCCCCTCTCACGGGCTCTCCCCTCCCCAGTGTGGCCGCGACCCTA
CCCTCTGCAAGGCGATGGCCCGCGCCCCGAGCGCAGGCTAGCGTGCCTGGGTGCCCGGCCATGGGCTGTATCGGCTCTCGGAGCCCGGCG
GGTCAGGCATTTCTGGGGACCAACAGCTGGCCGAGGCTCAGGGATAGAGACGGCTGCTCCAGCTAAAGGTGAATGTTGGAGACACAGTCG
CGATGCTGCCCAAGTCCCGGCGAGCCCTAACTATCCAGGAGATCGCTGCGCTGGCCAGGTCCTCCCTGCATGGTATTTCCCAGGTGGTGA
AGGACCACGTGACCAAGCCTACCGCCATGGCCCAGGGCCGAGTGGCTCACCTCATTGAGTGGAAGGGCTGGAGCAAGCCGAGTGACTCAC
CTGCTGCCCTGGAATCAGCCTTTTCCTCCTATTCAGACCTCAGCGAGGGCGAACAAGAGGCTCGCTTTGCAGCAGGAGTGGCTGAGCAGT
TTGCCATCGCGGAAGCCAAGCTCCGAGCATGGTCTTCGGTGGATGGCGAGGACTCCACTGATGACTCCTATGATGAGGACTTTGCTGGGG
GAATGGACACAGGTTGTGTGATAGCTGAGCTTTTTACAGAAGGTGTACCATTATTTGATCTCTCTCAACTTTTGGCTTATAGAAATGGAC
ATTTTTTCCCTGAACAAGTGCTAAATAAAATTGAAGATCACAGTATCAGAGAATTGGTAACTCAGATGATTCACCGTGAGCCAGATAAAC
GTTTAGAGGCAGAAGATTACTTAAAACAGCAGCGTGGCAATGCCTTTCCTGAAATATTTTACACTTTTCTTCAGCCCTACATGGCCCAGT
TTGCCAAGGAAACGTTTCTTTCTGCAGATGAGCGTATTCTGGTTATACGGAAGGATTTGGGCAACATTATTCACAATCTCTGTGGACATG
ATCTGCCAGAAAAAGCCGAAGGAGAGCCTAAGGAAAATGGGCTGGTTATCTTGGTATCTGTTATAACATCCTGCCTACAGACCCTTAAAT
ACTGTGATTCCAAACTAGCTGCTTTGGAACTGATTCTTCATTTGGCTCCAAGATTAAGTGTTGAAATCCTTTTGGATCGTATTACTCCAT
ATCTTTTGCATTTCAGCAATGACTCTGTTCCTAGGGTGAGGGCTGAAGCCTTGAGGACGTTGACCAAAGTTCTTGCTCTCGTCAAAGAGG
TTCCTCGTAATGATATCAATATTTATCCGGAATACATTCTGCCAGGCATAGCCCACTTAGCCCAAGATGATGCTACTATCGTTAGACTAG
CCTATGCTGAAAACATAGCTCTGCTGGCAGAAACAGCTCTGAGATTCCTGGAATTAGTACAGTTAAAAAATCTTAATATGGAAAATGACC
CCAATAATGAAGAAATAGATGAGGTTACACATCCAAATGGAAATTATGACACAGAGCTCCAAGCCTTACATGAAATGGTCCAGCAGAAAG
TTGTTACTTTGCTAAGTGACCCTGAAAATATTGTAAAACAAACCTTGATGGAAAATGGAATAACACGGCTGTGTGTATTCTTTGGACGTC
AGAAAGCCAACGATGTTTTGTTGTCCCACATGATTACTTTCCTAAATGATAAGAATGATTGGCATCTACGTGGAGCATTTTTTGATAGTA
TAGTTGGTGTTGCTGCCTATGTTGGCTGGCAAAGCTCCTCAATTCTCAAGCCTCTGCTGCAACAAGGTCTTAGTGATGCTGAGGAATTTG
TCATTGTGAAAGCTCTTTATGCCCTTACTTGTATGTGCCAGTTAGGACTGCTACAAAAACCCCATGTTTACGAATTTGCCAGTGATATTG
CCCCCTTCCTGTGTCATCCCAATTTATGGATACGTTATGGTGCCGTGGGATTTATCACAGTGGTAGCTCGTCAAATAAGTACAGCTGATG
TCTACTGTAAACTGATGCCTTATCTTGACCCATATATTACCCAACCAATAATACAGATTGAAAGAAAACTTGTTCTGCTCAGTGTTTTAA
AGGAACCAGTAAGTCGTTCTATATTTGATTATGCTTTGAGGTCTAAAGATATTACTAGCTTGTTCAGACATCTTCACATGCGTCAGAAGA
AACGAAATGGTTCTCTTCCCGACTGCCCTCCGCCAGAGGATCCTGCCATAGCACAGCTTCTGAAGAAGTTGCTCTCACAGGGAATGACAG
AGGAAGAGGAAGACAAACTTCTGGCACTGAAAGACTTCATGATGAAATCTAATAAAGCAAAGGCCAATATAGTGGACCAGAGCCATCTTC
ATGATAGTAGTCAGAAAGGTGTAATTGACTTGGCAGCTTTAGGCATAACTGGGAGACAAGTTGATCTTGTTAAAACCAAACAAGAACCAG
ATGACAAACGGGCCAGAAAACATGTAAAACAAGACTCAAATGTAAATGAAGAATGGAAAAGCATGTTTGGGTCACTGGACCCACCAAACA
TGCCACAGGCCCTACCTAAAGGGAGTGATCAGGAGGTGATTCAGACTGGGAAACCTCCTCGTTCCGAGTCCTCTGCTGGCATTTGTGTCC
CTTTGTCAACTTCTTCACAGGTTCCAGAAGTGACAACTGTCCAAAATAAAAAACCAGTAATACCGGTTTTAAGTAGTACAATCTTACCAT
CCACCTATCAGATTCGAATTACAACTTGTAAAACTGAACTTCAGCAACTCATCCAGCAAAAGCGGGAGCAGTGCAATGCTGAGAGAATAG
CTAAGCAGATGATGGAAAATGCTGAATGGGAGAGTAAACCACCACCACCTGGATGGCGTCCTAAAGGGCTGTTAGTTGCCCATCTTCATG
AGCATAAATCTGCTGTGAATCGAATTAGAGTCTCTGATGAACACTCACTTTTTGCAACATGTTCAAATGATGGCACAGTGAAAATCTGGA
ACAGTCAAAAGATGGAGGGGAAGACCACCACTACCAGATCTATTCTTACATACAGCCGAATTGGAGGACGAGTCAAGACGCTCACATTCT
GCCAAGGCTCCCACTATTTAGCCATAGCATCTGATAATGGTGCTGTCCAGCTTCTTGGAATTGAGGCTTCTAAGCTGCCCAAGTCTCCTA
AAATCCATCCTCTACAAAGCAGAATTCTAGATCAGAAGGAGGACGGTTGTGTTGTGGATATGCATCACTTCAACTCTGGAGCACAGTCTG
TTCTTGCCTATGCCACTGTGAATGGCTCTCTGGTTGGCTGGGACCTTAGGTCTTCAAGCAATGCGTGGACTTTAAAGCATGATTTAAAGT
CGGGCCTCATCACTTCCTTTGCTGTGGACATCCACCAATGCTGGCTCTGCATTGGTACAAGCAGTGGTACCATGGCTTGTTGGGACATGA
GGTTCCAGTTGCCAATTTCAAGTCACTGTCATCCTTCCAGGGCTCGAATCAGACGCCTCTCAATGCACCCTCTGTATCAGTCCTGGGTGA
TTGCAGCTGTTCAGGGCAACAACGAAGTGTCCATGTGGGACATGGAGACTGGTGACAGAAGATTTACTCTCTGGGCCAGCAGTGCACCAC
CACTTTCTGAATTACAGCCTTCTCCTCATAGCGTCCATGGTATCTACTGTAGTCCTGCAGATGGAAATCCTATCCTACTAACAGCTGGCT
CAGATATGAAAATAAGGTTTTGGGACTTGGCTTACCCAGAAAGGTCCTATGTTGTTGCAGGAAGTACTAGTTCCCCATCTGTGTCCTACT
ACAGGAAAATAATTGAAGGCACTGAAGTTGTCCAGGAAATTCAGAATAAGCAGAAAGTAGGACCAAGTGATGACACCCCTCGAAGGGGCC
CAGAGTCCCTGCCCGTGGGACATCATGACATCATCACTGATGTCGCCACATTCCAGACCACACAGGGCTTCATCGTAACTGCTTCTAGAG
ATGGGATTGTGAAGGTGTGGAAATAAAACCTACTGATTTGTATAAATTTTAATAGTTATAAATATAATACTATAACTCGAGAAAAGGCAT
TTCTAGAGAACAGATTCATTTGCTTAATTTTCAAAATTATGTCTCCATATTACTGTTTCATGACTGACTGACTAAATGACACCCAAAATG
GTTAAGATGTACTTGACTAGTTTACTTATGCATCTCTTTGCAAGAATCAGCCAGCCAACAATGTCTGGGATTTTTATTGTATATGTTATA
GAGGTGAGAAATGTAAAATATGAAAATGAATATGTTTATTTTGTATTGAAAAAGATGGTTGAAAAGATGGTTGTAAGCTATTATAGTATA

>28484_28484_2_FAM131A-PIK3R4_FAM131A_chr3_184060648_ENST00000340957_PIK3R4_chr3_130454846_ENST00000356763_length(amino acids)=1250AA_BP=136
MLQLKVNVGDTVAMLPKSRRALTIQEIAALARSSLHGISQVVKDHVTKPTAMAQGRVAHLIEWKGWSKPSDSPAALESAFSSYSDLSEGE
QEARFAAGVAEQFAIAEAKLRAWSSVDGEDSTDDSYDEDFAGGMDTGCVIAELFTEGVPLFDLSQLLAYRNGHFFPEQVLNKIEDHSIRE
LVTQMIHREPDKRLEAEDYLKQQRGNAFPEIFYTFLQPYMAQFAKETFLSADERILVIRKDLGNIIHNLCGHDLPEKAEGEPKENGLVIL
VSVITSCLQTLKYCDSKLAALELILHLAPRLSVEILLDRITPYLLHFSNDSVPRVRAEALRTLTKVLALVKEVPRNDINIYPEYILPGIA
HLAQDDATIVRLAYAENIALLAETALRFLELVQLKNLNMENDPNNEEIDEVTHPNGNYDTELQALHEMVQQKVVTLLSDPENIVKQTLME
NGITRLCVFFGRQKANDVLLSHMITFLNDKNDWHLRGAFFDSIVGVAAYVGWQSSSILKPLLQQGLSDAEEFVIVKALYALTCMCQLGLL
QKPHVYEFASDIAPFLCHPNLWIRYGAVGFITVVARQISTADVYCKLMPYLDPYITQPIIQIERKLVLLSVLKEPVSRSIFDYALRSKDI
TSLFRHLHMRQKKRNGSLPDCPPPEDPAIAQLLKKLLSQGMTEEEEDKLLALKDFMMKSNKAKANIVDQSHLHDSSQKGVIDLAALGITG
RQVDLVKTKQEPDDKRARKHVKQDSNVNEEWKSMFGSLDPPNMPQALPKGSDQEVIQTGKPPRSESSAGICVPLSTSSQVPEVTTVQNKK
PVIPVLSSTILPSTYQIRITTCKTELQQLIQQKREQCNAERIAKQMMENAEWESKPPPPGWRPKGLLVAHLHEHKSAVNRIRVSDEHSLF
ATCSNDGTVKIWNSQKMEGKTTTTRSILTYSRIGGRVKTLTFCQGSHYLAIASDNGAVQLLGIEASKLPKSPKIHPLQSRILDQKEDGCV
VDMHHFNSGAQSVLAYATVNGSLVGWDLRSSSNAWTLKHDLKSGLITSFAVDIHQCWLCIGTSSGTMACWDMRFQLPISSHCHPSRARIR
RLSMHPLYQSWVIAAVQGNNEVSMWDMETGDRRFTLWASSAPPLSELQPSPHSVHGIYCSPADGNPILLTAGSDMKIRFWDLAYPERSYV

--------------------------------------------------------------
>28484_28484_3_FAM131A-PIK3R4_FAM131A_chr3_184060648_ENST00000383847_PIK3R4_chr3_130454846_ENST00000356763_length(transcript)=4528nt_BP=804nt
GCCCTGGTGTTCCCACCTCCTCAGAGCCATGAGGCAGGAATGTTCTCCTTATGTGACTAGGCACAGGTTCCAAATGGGGAGGGGACTGGC
TCAGCATCCGGAGCCAAAACAGGAATAGAACTGGGAGCTGAGCCTGGAGCGGTTCTGGGCTTTTGGTTCTCTGCATCAACACAGCCAGCA
TGCCTATGATTTCTGTGCTGGGCAAAATGTTTCTGTGGCAGCGTGAAGGGCCTGGAGGACGATGGACTTGTCAGACAAGTCGCAGAGTGT
CCTCGGACCCCGCTTGGGCTGTGGAGTGGATCGAACTTCCTCGGGGTCTCTCTCTATCCTCTTTGGGATCTGCTCGAACCCTCCGAGGCT
GGAGCAGGTCCTCCCGCCCTTCCTCGGTGGACAGTCAGGACTTGCCAGAGGTGAATGTTGGAGACACAGTCGCGATGCTGCCCAAGTCCC
GGCGAGCCCTAACTATCCAGGAGATCGCTGCGCTGGCCAGGTCCTCCCTGCATGGTATTTCCCAGGTGGTGAAGGACCACGTGACCAAGC
CTACCGCCATGGCCCAGGGCCGAGTGGCTCACCTCATTGAGTGGAAGGGCTGGAGCAAGCCGAGTGACTCACCTGCTGCCCTGGAATCAG
CCTTTTCCTCCTATTCAGACCTCAGCGAGGGCGAACAAGAGGCTCGCTTTGCAGCAGGAGTGGCTGAGCAGTTTGCCATCGCGGAAGCCA
AGCTCCGAGCATGGTCTTCGGTGGATGGCGAGGACTCCACTGATGACTCCTATGATGAGGACTTTGCTGGGGGAATGGACACAGGTTGTG
TGATAGCTGAGCTTTTTACAGAAGGTGTACCATTATTTGATCTCTCTCAACTTTTGGCTTATAGAAATGGACATTTTTTCCCTGAACAAG
TGCTAAATAAAATTGAAGATCACAGTATCAGAGAATTGGTAACTCAGATGATTCACCGTGAGCCAGATAAACGTTTAGAGGCAGAAGATT
ACTTAAAACAGCAGCGTGGCAATGCCTTTCCTGAAATATTTTACACTTTTCTTCAGCCCTACATGGCCCAGTTTGCCAAGGAAACGTTTC
TTTCTGCAGATGAGCGTATTCTGGTTATACGGAAGGATTTGGGCAACATTATTCACAATCTCTGTGGACATGATCTGCCAGAAAAAGCCG
AAGGAGAGCCTAAGGAAAATGGGCTGGTTATCTTGGTATCTGTTATAACATCCTGCCTACAGACCCTTAAATACTGTGATTCCAAACTAG
CTGCTTTGGAACTGATTCTTCATTTGGCTCCAAGATTAAGTGTTGAAATCCTTTTGGATCGTATTACTCCATATCTTTTGCATTTCAGCA
ATGACTCTGTTCCTAGGGTGAGGGCTGAAGCCTTGAGGACGTTGACCAAAGTTCTTGCTCTCGTCAAAGAGGTTCCTCGTAATGATATCA
ATATTTATCCGGAATACATTCTGCCAGGCATAGCCCACTTAGCCCAAGATGATGCTACTATCGTTAGACTAGCCTATGCTGAAAACATAG
CTCTGCTGGCAGAAACAGCTCTGAGATTCCTGGAATTAGTACAGTTAAAAAATCTTAATATGGAAAATGACCCCAATAATGAAGAAATAG
ATGAGGTTACACATCCAAATGGAAATTATGACACAGAGCTCCAAGCCTTACATGAAATGGTCCAGCAGAAAGTTGTTACTTTGCTAAGTG
ACCCTGAAAATATTGTAAAACAAACCTTGATGGAAAATGGAATAACACGGCTGTGTGTATTCTTTGGACGTCAGAAAGCCAACGATGTTT
TGTTGTCCCACATGATTACTTTCCTAAATGATAAGAATGATTGGCATCTACGTGGAGCATTTTTTGATAGTATAGTTGGTGTTGCTGCCT
ATGTTGGCTGGCAAAGCTCCTCAATTCTCAAGCCTCTGCTGCAACAAGGTCTTAGTGATGCTGAGGAATTTGTCATTGTGAAAGCTCTTT
ATGCCCTTACTTGTATGTGCCAGTTAGGACTGCTACAAAAACCCCATGTTTACGAATTTGCCAGTGATATTGCCCCCTTCCTGTGTCATC
CCAATTTATGGATACGTTATGGTGCCGTGGGATTTATCACAGTGGTAGCTCGTCAAATAAGTACAGCTGATGTCTACTGTAAACTGATGC
CTTATCTTGACCCATATATTACCCAACCAATAATACAGATTGAAAGAAAACTTGTTCTGCTCAGTGTTTTAAAGGAACCAGTAAGTCGTT
CTATATTTGATTATGCTTTGAGGTCTAAAGATATTACTAGCTTGTTCAGACATCTTCACATGCGTCAGAAGAAACGAAATGGTTCTCTTC
CCGACTGCCCTCCGCCAGAGGATCCTGCCATAGCACAGCTTCTGAAGAAGTTGCTCTCACAGGGAATGACAGAGGAAGAGGAAGACAAAC
TTCTGGCACTGAAAGACTTCATGATGAAATCTAATAAAGCAAAGGCCAATATAGTGGACCAGAGCCATCTTCATGATAGTAGTCAGAAAG
GTGTAATTGACTTGGCAGCTTTAGGCATAACTGGGAGACAAGTTGATCTTGTTAAAACCAAACAAGAACCAGATGACAAACGGGCCAGAA
AACATGTAAAACAAGACTCAAATGTAAATGAAGAATGGAAAAGCATGTTTGGGTCACTGGACCCACCAAACATGCCACAGGCCCTACCTA
AAGGGAGTGATCAGGAGGTGATTCAGACTGGGAAACCTCCTCGTTCCGAGTCCTCTGCTGGCATTTGTGTCCCTTTGTCAACTTCTTCAC
AGGTTCCAGAAGTGACAACTGTCCAAAATAAAAAACCAGTAATACCGGTTTTAAGTAGTACAATCTTACCATCCACCTATCAGATTCGAA
TTACAACTTGTAAAACTGAACTTCAGCAACTCATCCAGCAAAAGCGGGAGCAGTGCAATGCTGAGAGAATAGCTAAGCAGATGATGGAAA
ATGCTGAATGGGAGAGTAAACCACCACCACCTGGATGGCGTCCTAAAGGGCTGTTAGTTGCCCATCTTCATGAGCATAAATCTGCTGTGA
ATCGAATTAGAGTCTCTGATGAACACTCACTTTTTGCAACATGTTCAAATGATGGCACAGTGAAAATCTGGAACAGTCAAAAGATGGAGG
GGAAGACCACCACTACCAGATCTATTCTTACATACAGCCGAATTGGAGGACGAGTCAAGACGCTCACATTCTGCCAAGGCTCCCACTATT
TAGCCATAGCATCTGATAATGGTGCTGTCCAGCTTCTTGGAATTGAGGCTTCTAAGCTGCCCAAGTCTCCTAAAATCCATCCTCTACAAA
GCAGAATTCTAGATCAGAAGGAGGACGGTTGTGTTGTGGATATGCATCACTTCAACTCTGGAGCACAGTCTGTTCTTGCCTATGCCACTG
TGAATGGCTCTCTGGTTGGCTGGGACCTTAGGTCTTCAAGCAATGCGTGGACTTTAAAGCATGATTTAAAGTCGGGCCTCATCACTTCCT
TTGCTGTGGACATCCACCAATGCTGGCTCTGCATTGGTACAAGCAGTGGTACCATGGCTTGTTGGGACATGAGGTTCCAGTTGCCAATTT
CAAGTCACTGTCATCCTTCCAGGGCTCGAATCAGACGCCTCTCAATGCACCCTCTGTATCAGTCCTGGGTGATTGCAGCTGTTCAGGGCA
ACAACGAAGTGTCCATGTGGGACATGGAGACTGGTGACAGAAGATTTACTCTCTGGGCCAGCAGTGCACCACCACTTTCTGAATTACAGC
CTTCTCCTCATAGCGTCCATGGTATCTACTGTAGTCCTGCAGATGGAAATCCTATCCTACTAACAGCTGGCTCAGATATGAAAATAAGGT
TTTGGGACTTGGCTTACCCAGAAAGGTCCTATGTTGTTGCAGGAAGTACTAGTTCCCCATCTGTGTCCTACTACAGGAAAATAATTGAAG
GCACTGAAGTTGTCCAGGAAATTCAGAATAAGCAGAAAGTAGGACCAAGTGATGACACCCCTCGAAGGGGCCCAGAGTCCCTGCCCGTGG
GACATCATGACATCATCACTGATGTCGCCACATTCCAGACCACACAGGGCTTCATCGTAACTGCTTCTAGAGATGGGATTGTGAAGGTGT
GGAAATAAAACCTACTGATTTGTATAAATTTTAATAGTTATAAATATAATACTATAACTCGAGAAAAGGCATTTCTAGAGAACAGATTCA
TTTGCTTAATTTTCAAAATTATGTCTCCATATTACTGTTTCATGACTGACTGACTAAATGACACCCAAAATGGTTAAGATGTACTTGACT
AGTTTACTTATGCATCTCTTTGCAAGAATCAGCCAGCCAACAATGTCTGGGATTTTTATTGTATATGTTATAGAGGTGAGAAATGTAAAA
TATGAAAATGAATATGTTTATTTTGTATTGAAAAAGATGGTTGAAAAGATGGTTGTAAGCTATTATAGTATAAACACATTTTTGCTATTA

>28484_28484_3_FAM131A-PIK3R4_FAM131A_chr3_184060648_ENST00000383847_PIK3R4_chr3_130454846_ENST00000356763_length(amino acids)=1331AA_BP=217
MVLCINTASMPMISVLGKMFLWQREGPGGRWTCQTSRRVSSDPAWAVEWIELPRGLSLSSLGSARTLRGWSRSSRPSSVDSQDLPEVNVG
DTVAMLPKSRRALTIQEIAALARSSLHGISQVVKDHVTKPTAMAQGRVAHLIEWKGWSKPSDSPAALESAFSSYSDLSEGEQEARFAAGV
AEQFAIAEAKLRAWSSVDGEDSTDDSYDEDFAGGMDTGCVIAELFTEGVPLFDLSQLLAYRNGHFFPEQVLNKIEDHSIRELVTQMIHRE
PDKRLEAEDYLKQQRGNAFPEIFYTFLQPYMAQFAKETFLSADERILVIRKDLGNIIHNLCGHDLPEKAEGEPKENGLVILVSVITSCLQ
TLKYCDSKLAALELILHLAPRLSVEILLDRITPYLLHFSNDSVPRVRAEALRTLTKVLALVKEVPRNDINIYPEYILPGIAHLAQDDATI
VRLAYAENIALLAETALRFLELVQLKNLNMENDPNNEEIDEVTHPNGNYDTELQALHEMVQQKVVTLLSDPENIVKQTLMENGITRLCVF
FGRQKANDVLLSHMITFLNDKNDWHLRGAFFDSIVGVAAYVGWQSSSILKPLLQQGLSDAEEFVIVKALYALTCMCQLGLLQKPHVYEFA
SDIAPFLCHPNLWIRYGAVGFITVVARQISTADVYCKLMPYLDPYITQPIIQIERKLVLLSVLKEPVSRSIFDYALRSKDITSLFRHLHM
RQKKRNGSLPDCPPPEDPAIAQLLKKLLSQGMTEEEEDKLLALKDFMMKSNKAKANIVDQSHLHDSSQKGVIDLAALGITGRQVDLVKTK
QEPDDKRARKHVKQDSNVNEEWKSMFGSLDPPNMPQALPKGSDQEVIQTGKPPRSESSAGICVPLSTSSQVPEVTTVQNKKPVIPVLSST
ILPSTYQIRITTCKTELQQLIQQKREQCNAERIAKQMMENAEWESKPPPPGWRPKGLLVAHLHEHKSAVNRIRVSDEHSLFATCSNDGTV
KIWNSQKMEGKTTTTRSILTYSRIGGRVKTLTFCQGSHYLAIASDNGAVQLLGIEASKLPKSPKIHPLQSRILDQKEDGCVVDMHHFNSG
AQSVLAYATVNGSLVGWDLRSSSNAWTLKHDLKSGLITSFAVDIHQCWLCIGTSSGTMACWDMRFQLPISSHCHPSRARIRRLSMHPLYQ
SWVIAAVQGNNEVSMWDMETGDRRFTLWASSAPPLSELQPSPHSVHGIYCSPADGNPILLTAGSDMKIRFWDLAYPERSYVVAGSTSSPS

--------------------------------------------------------------
>28484_28484_4_FAM131A-PIK3R4_FAM131A_chr3_184060648_ENST00000418281_PIK3R4_chr3_130454846_ENST00000356763_length(transcript)=4280nt_BP=556nt
ACCGGCCCGGTTCCCTCTCCGGGGAGCGGCGGCGGACGCGCGGCTCCCACCCCTCCCCTCTCACGGGCTCTCCCCTCCCCAGTGTGGCCG
CGACCCTACCCTCTGCAAGGCGATGGCCCGCGCCCCGAGCGCAGGCTAGCGTGCCTGGGTGCCCGGCCATGGGCTGTATCGGCTCTCGGA
GCCCGGCGGGTCAGGCATTTCTGGGGACCAACAGCTGGCCGAGGCTCAGGGATAGAGACGGCTGCTCCAGCTAAAGGTATTTCCCAGGTG
GTGAAGGACCACGTGACCAAGCCTACCGCCATGGCCCAGGGCCGAGTGGCTCACCTCATTGAGTGGAAGGGCTGGAGCAAGCCGAGTGAC
TCACCTGCTGCCCTGGAATCAGCCTTTTCCTCCTATTCAGACCTCAGCGAGGGCGAACAAGAGGCTCGCTTTGCAGCAGGAGTGGCTGAG
CAGTTTGCCATCGCGGAAGCCAAGCTCCGAGCATGGTCTTCGGTGGATGGCGAGGACTCCACTGATGACTCCTATGATGAGGACTTTGCT
GGGGGAATGGACACAGGTTGTGTGATAGCTGAGCTTTTTACAGAAGGTGTACCATTATTTGATCTCTCTCAACTTTTGGCTTATAGAAAT
GGACATTTTTTCCCTGAACAAGTGCTAAATAAAATTGAAGATCACAGTATCAGAGAATTGGTAACTCAGATGATTCACCGTGAGCCAGAT
AAACGTTTAGAGGCAGAAGATTACTTAAAACAGCAGCGTGGCAATGCCTTTCCTGAAATATTTTACACTTTTCTTCAGCCCTACATGGCC
CAGTTTGCCAAGGAAACGTTTCTTTCTGCAGATGAGCGTATTCTGGTTATACGGAAGGATTTGGGCAACATTATTCACAATCTCTGTGGA
CATGATCTGCCAGAAAAAGCCGAAGGAGAGCCTAAGGAAAATGGGCTGGTTATCTTGGTATCTGTTATAACATCCTGCCTACAGACCCTT
AAATACTGTGATTCCAAACTAGCTGCTTTGGAACTGATTCTTCATTTGGCTCCAAGATTAAGTGTTGAAATCCTTTTGGATCGTATTACT
CCATATCTTTTGCATTTCAGCAATGACTCTGTTCCTAGGGTGAGGGCTGAAGCCTTGAGGACGTTGACCAAAGTTCTTGCTCTCGTCAAA
GAGGTTCCTCGTAATGATATCAATATTTATCCGGAATACATTCTGCCAGGCATAGCCCACTTAGCCCAAGATGATGCTACTATCGTTAGA
CTAGCCTATGCTGAAAACATAGCTCTGCTGGCAGAAACAGCTCTGAGATTCCTGGAATTAGTACAGTTAAAAAATCTTAATATGGAAAAT
GACCCCAATAATGAAGAAATAGATGAGGTTACACATCCAAATGGAAATTATGACACAGAGCTCCAAGCCTTACATGAAATGGTCCAGCAG
AAAGTTGTTACTTTGCTAAGTGACCCTGAAAATATTGTAAAACAAACCTTGATGGAAAATGGAATAACACGGCTGTGTGTATTCTTTGGA
CGTCAGAAAGCCAACGATGTTTTGTTGTCCCACATGATTACTTTCCTAAATGATAAGAATGATTGGCATCTACGTGGAGCATTTTTTGAT
AGTATAGTTGGTGTTGCTGCCTATGTTGGCTGGCAAAGCTCCTCAATTCTCAAGCCTCTGCTGCAACAAGGTCTTAGTGATGCTGAGGAA
TTTGTCATTGTGAAAGCTCTTTATGCCCTTACTTGTATGTGCCAGTTAGGACTGCTACAAAAACCCCATGTTTACGAATTTGCCAGTGAT
ATTGCCCCCTTCCTGTGTCATCCCAATTTATGGATACGTTATGGTGCCGTGGGATTTATCACAGTGGTAGCTCGTCAAATAAGTACAGCT
GATGTCTACTGTAAACTGATGCCTTATCTTGACCCATATATTACCCAACCAATAATACAGATTGAAAGAAAACTTGTTCTGCTCAGTGTT
TTAAAGGAACCAGTAAGTCGTTCTATATTTGATTATGCTTTGAGGTCTAAAGATATTACTAGCTTGTTCAGACATCTTCACATGCGTCAG
AAGAAACGAAATGGTTCTCTTCCCGACTGCCCTCCGCCAGAGGATCCTGCCATAGCACAGCTTCTGAAGAAGTTGCTCTCACAGGGAATG
ACAGAGGAAGAGGAAGACAAACTTCTGGCACTGAAAGACTTCATGATGAAATCTAATAAAGCAAAGGCCAATATAGTGGACCAGAGCCAT
CTTCATGATAGTAGTCAGAAAGGTGTAATTGACTTGGCAGCTTTAGGCATAACTGGGAGACAAGTTGATCTTGTTAAAACCAAACAAGAA
CCAGATGACAAACGGGCCAGAAAACATGTAAAACAAGACTCAAATGTAAATGAAGAATGGAAAAGCATGTTTGGGTCACTGGACCCACCA
AACATGCCACAGGCCCTACCTAAAGGGAGTGATCAGGAGGTGATTCAGACTGGGAAACCTCCTCGTTCCGAGTCCTCTGCTGGCATTTGT
GTCCCTTTGTCAACTTCTTCACAGGTTCCAGAAGTGACAACTGTCCAAAATAAAAAACCAGTAATACCGGTTTTAAGTAGTACAATCTTA
CCATCCACCTATCAGATTCGAATTACAACTTGTAAAACTGAACTTCAGCAACTCATCCAGCAAAAGCGGGAGCAGTGCAATGCTGAGAGA
ATAGCTAAGCAGATGATGGAAAATGCTGAATGGGAGAGTAAACCACCACCACCTGGATGGCGTCCTAAAGGGCTGTTAGTTGCCCATCTT
CATGAGCATAAATCTGCTGTGAATCGAATTAGAGTCTCTGATGAACACTCACTTTTTGCAACATGTTCAAATGATGGCACAGTGAAAATC
TGGAACAGTCAAAAGATGGAGGGGAAGACCACCACTACCAGATCTATTCTTACATACAGCCGAATTGGAGGACGAGTCAAGACGCTCACA
TTCTGCCAAGGCTCCCACTATTTAGCCATAGCATCTGATAATGGTGCTGTCCAGCTTCTTGGAATTGAGGCTTCTAAGCTGCCCAAGTCT
CCTAAAATCCATCCTCTACAAAGCAGAATTCTAGATCAGAAGGAGGACGGTTGTGTTGTGGATATGCATCACTTCAACTCTGGAGCACAG
TCTGTTCTTGCCTATGCCACTGTGAATGGCTCTCTGGTTGGCTGGGACCTTAGGTCTTCAAGCAATGCGTGGACTTTAAAGCATGATTTA
AAGTCGGGCCTCATCACTTCCTTTGCTGTGGACATCCACCAATGCTGGCTCTGCATTGGTACAAGCAGTGGTACCATGGCTTGTTGGGAC
ATGAGGTTCCAGTTGCCAATTTCAAGTCACTGTCATCCTTCCAGGGCTCGAATCAGACGCCTCTCAATGCACCCTCTGTATCAGTCCTGG
GTGATTGCAGCTGTTCAGGGCAACAACGAAGTGTCCATGTGGGACATGGAGACTGGTGACAGAAGATTTACTCTCTGGGCCAGCAGTGCA
CCACCACTTTCTGAATTACAGCCTTCTCCTCATAGCGTCCATGGTATCTACTGTAGTCCTGCAGATGGAAATCCTATCCTACTAACAGCT
GGCTCAGATATGAAAATAAGGTTTTGGGACTTGGCTTACCCAGAAAGGTCCTATGTTGTTGCAGGAAGTACTAGTTCCCCATCTGTGTCC
TACTACAGGAAAATAATTGAAGGCACTGAAGTTGTCCAGGAAATTCAGAATAAGCAGAAAGTAGGACCAAGTGATGACACCCCTCGAAGG
GGCCCAGAGTCCCTGCCCGTGGGACATCATGACATCATCACTGATGTCGCCACATTCCAGACCACACAGGGCTTCATCGTAACTGCTTCT
AGAGATGGGATTGTGAAGGTGTGGAAATAAAACCTACTGATTTGTATAAATTTTAATAGTTATAAATATAATACTATAACTCGAGAAAAG
GCATTTCTAGAGAACAGATTCATTTGCTTAATTTTCAAAATTATGTCTCCATATTACTGTTTCATGACTGACTGACTAAATGACACCCAA
AATGGTTAAGATGTACTTGACTAGTTTACTTATGCATCTCTTTGCAAGAATCAGCCAGCCAACAATGTCTGGGATTTTTATTGTATATGT
TATAGAGGTGAGAAATGTAAAATATGAAAATGAATATGTTTATTTTGTATTGAAAAAGATGGTTGAAAAGATGGTTGTAAGCTATTATAG

>28484_28484_4_FAM131A-PIK3R4_FAM131A_chr3_184060648_ENST00000418281_PIK3R4_chr3_130454846_ENST00000356763_length(amino acids)=1265AA_BP=151
MQGDGPRPERRLACLGARPWAVSALGARRVRHFWGPTAGRGSGIETAAPAKGISQVVKDHVTKPTAMAQGRVAHLIEWKGWSKPSDSPAA
LESAFSSYSDLSEGEQEARFAAGVAEQFAIAEAKLRAWSSVDGEDSTDDSYDEDFAGGMDTGCVIAELFTEGVPLFDLSQLLAYRNGHFF
PEQVLNKIEDHSIRELVTQMIHREPDKRLEAEDYLKQQRGNAFPEIFYTFLQPYMAQFAKETFLSADERILVIRKDLGNIIHNLCGHDLP
EKAEGEPKENGLVILVSVITSCLQTLKYCDSKLAALELILHLAPRLSVEILLDRITPYLLHFSNDSVPRVRAEALRTLTKVLALVKEVPR
NDINIYPEYILPGIAHLAQDDATIVRLAYAENIALLAETALRFLELVQLKNLNMENDPNNEEIDEVTHPNGNYDTELQALHEMVQQKVVT
LLSDPENIVKQTLMENGITRLCVFFGRQKANDVLLSHMITFLNDKNDWHLRGAFFDSIVGVAAYVGWQSSSILKPLLQQGLSDAEEFVIV
KALYALTCMCQLGLLQKPHVYEFASDIAPFLCHPNLWIRYGAVGFITVVARQISTADVYCKLMPYLDPYITQPIIQIERKLVLLSVLKEP
VSRSIFDYALRSKDITSLFRHLHMRQKKRNGSLPDCPPPEDPAIAQLLKKLLSQGMTEEEEDKLLALKDFMMKSNKAKANIVDQSHLHDS
SQKGVIDLAALGITGRQVDLVKTKQEPDDKRARKHVKQDSNVNEEWKSMFGSLDPPNMPQALPKGSDQEVIQTGKPPRSESSAGICVPLS
TSSQVPEVTTVQNKKPVIPVLSSTILPSTYQIRITTCKTELQQLIQQKREQCNAERIAKQMMENAEWESKPPPPGWRPKGLLVAHLHEHK
SAVNRIRVSDEHSLFATCSNDGTVKIWNSQKMEGKTTTTRSILTYSRIGGRVKTLTFCQGSHYLAIASDNGAVQLLGIEASKLPKSPKIH
PLQSRILDQKEDGCVVDMHHFNSGAQSVLAYATVNGSLVGWDLRSSSNAWTLKHDLKSGLITSFAVDIHQCWLCIGTSSGTMACWDMRFQ
LPISSHCHPSRARIRRLSMHPLYQSWVIAAVQGNNEVSMWDMETGDRRFTLWASSAPPLSELQPSPHSVHGIYCSPADGNPILLTAGSDM
KIRFWDLAYPERSYVVAGSTSSPSVSYYRKIIEGTEVVQEIQNKQKVGPSDDTPRRGPESLPVGHHDIITDVATFQTTQGFIVTASRDGI

--------------------------------------------------------------
>28484_28484_5_FAM131A-PIK3R4_FAM131A_chr3_184060648_ENST00000450976_PIK3R4_chr3_130454846_ENST00000356763_length(transcript)=4520nt_BP=796nt
GTCACCGGCCCGGTTCCCTCTCCGGGGAGCGGCGGCGGACGCGCGGCTCCCACCCCTCCCCTCTCACGGGCTCTCCCCTCCCCAGTGTGG
CCGCGACCCTACCCTCTGCAAGGCGATGGCCCGCGCCCCGAGCGCAGGCTAGCGTGCCTGGGTGCCCGGCCATGGGCTGTATCGGCTCTC
GGAGCCCGGCGGGTCAGGCATTTCTGGGGACCAACAGCTGGCCGAGGCTCAGGGATAGAGACGGCTGCTCCAGCTAAAGTGTCCTCGGAC
CCCGCTTGGGCTGTGGAGTGGATCGAACTTCCTCGGGGTCTCTCTCTATCCTCTTTGGGATCTGCTCGAACCCTCCGAGGCTGGAGCAGG
TCCTCCCGCCCTTCCTCGGTGGACAGTCAGGACTTGCCAGAGGTGAATGTTGGAGACACAGTCGCGATGCTGCCCAAGTCCCGGCGAGCC
CTAACTATCCAGGAGATCGCTGCGCTGGCCAGGTCCTCCCTGCATGGTATTTCCCAGGTGGTGAAGGACCACGTGACCAAGCCTACCGCC
ATGGCCCAGGGCCGAGTGGCTCACCTCATTGAGTGGAAGGGCTGGAGCAAGCCGAGTGACTCACCTGCTGCCCTGGAATCAGCCTTTTCC
TCCTATTCAGACCTCAGCGAGGGCGAACAAGAGGCTCGCTTTGCAGCAGGAGTGGCTGAGCAGTTTGCCATCGCGGAAGCCAAGCTCCGA
GCATGGTCTTCGGTGGATGGCGAGGACTCCACTGATGACTCCTATGATGAGGACTTTGCTGGGGGAATGGACACAGGTTGTGTGATAGCT
GAGCTTTTTACAGAAGGTGTACCATTATTTGATCTCTCTCAACTTTTGGCTTATAGAAATGGACATTTTTTCCCTGAACAAGTGCTAAAT
AAAATTGAAGATCACAGTATCAGAGAATTGGTAACTCAGATGATTCACCGTGAGCCAGATAAACGTTTAGAGGCAGAAGATTACTTAAAA
CAGCAGCGTGGCAATGCCTTTCCTGAAATATTTTACACTTTTCTTCAGCCCTACATGGCCCAGTTTGCCAAGGAAACGTTTCTTTCTGCA
GATGAGCGTATTCTGGTTATACGGAAGGATTTGGGCAACATTATTCACAATCTCTGTGGACATGATCTGCCAGAAAAAGCCGAAGGAGAG
CCTAAGGAAAATGGGCTGGTTATCTTGGTATCTGTTATAACATCCTGCCTACAGACCCTTAAATACTGTGATTCCAAACTAGCTGCTTTG
GAACTGATTCTTCATTTGGCTCCAAGATTAAGTGTTGAAATCCTTTTGGATCGTATTACTCCATATCTTTTGCATTTCAGCAATGACTCT
GTTCCTAGGGTGAGGGCTGAAGCCTTGAGGACGTTGACCAAAGTTCTTGCTCTCGTCAAAGAGGTTCCTCGTAATGATATCAATATTTAT
CCGGAATACATTCTGCCAGGCATAGCCCACTTAGCCCAAGATGATGCTACTATCGTTAGACTAGCCTATGCTGAAAACATAGCTCTGCTG
GCAGAAACAGCTCTGAGATTCCTGGAATTAGTACAGTTAAAAAATCTTAATATGGAAAATGACCCCAATAATGAAGAAATAGATGAGGTT
ACACATCCAAATGGAAATTATGACACAGAGCTCCAAGCCTTACATGAAATGGTCCAGCAGAAAGTTGTTACTTTGCTAAGTGACCCTGAA
AATATTGTAAAACAAACCTTGATGGAAAATGGAATAACACGGCTGTGTGTATTCTTTGGACGTCAGAAAGCCAACGATGTTTTGTTGTCC
CACATGATTACTTTCCTAAATGATAAGAATGATTGGCATCTACGTGGAGCATTTTTTGATAGTATAGTTGGTGTTGCTGCCTATGTTGGC
TGGCAAAGCTCCTCAATTCTCAAGCCTCTGCTGCAACAAGGTCTTAGTGATGCTGAGGAATTTGTCATTGTGAAAGCTCTTTATGCCCTT
ACTTGTATGTGCCAGTTAGGACTGCTACAAAAACCCCATGTTTACGAATTTGCCAGTGATATTGCCCCCTTCCTGTGTCATCCCAATTTA
TGGATACGTTATGGTGCCGTGGGATTTATCACAGTGGTAGCTCGTCAAATAAGTACAGCTGATGTCTACTGTAAACTGATGCCTTATCTT
GACCCATATATTACCCAACCAATAATACAGATTGAAAGAAAACTTGTTCTGCTCAGTGTTTTAAAGGAACCAGTAAGTCGTTCTATATTT
GATTATGCTTTGAGGTCTAAAGATATTACTAGCTTGTTCAGACATCTTCACATGCGTCAGAAGAAACGAAATGGTTCTCTTCCCGACTGC
CCTCCGCCAGAGGATCCTGCCATAGCACAGCTTCTGAAGAAGTTGCTCTCACAGGGAATGACAGAGGAAGAGGAAGACAAACTTCTGGCA
CTGAAAGACTTCATGATGAAATCTAATAAAGCAAAGGCCAATATAGTGGACCAGAGCCATCTTCATGATAGTAGTCAGAAAGGTGTAATT
GACTTGGCAGCTTTAGGCATAACTGGGAGACAAGTTGATCTTGTTAAAACCAAACAAGAACCAGATGACAAACGGGCCAGAAAACATGTA
AAACAAGACTCAAATGTAAATGAAGAATGGAAAAGCATGTTTGGGTCACTGGACCCACCAAACATGCCACAGGCCCTACCTAAAGGGAGT
GATCAGGAGGTGATTCAGACTGGGAAACCTCCTCGTTCCGAGTCCTCTGCTGGCATTTGTGTCCCTTTGTCAACTTCTTCACAGGTTCCA
GAAGTGACAACTGTCCAAAATAAAAAACCAGTAATACCGGTTTTAAGTAGTACAATCTTACCATCCACCTATCAGATTCGAATTACAACT
TGTAAAACTGAACTTCAGCAACTCATCCAGCAAAAGCGGGAGCAGTGCAATGCTGAGAGAATAGCTAAGCAGATGATGGAAAATGCTGAA
TGGGAGAGTAAACCACCACCACCTGGATGGCGTCCTAAAGGGCTGTTAGTTGCCCATCTTCATGAGCATAAATCTGCTGTGAATCGAATT
AGAGTCTCTGATGAACACTCACTTTTTGCAACATGTTCAAATGATGGCACAGTGAAAATCTGGAACAGTCAAAAGATGGAGGGGAAGACC
ACCACTACCAGATCTATTCTTACATACAGCCGAATTGGAGGACGAGTCAAGACGCTCACATTCTGCCAAGGCTCCCACTATTTAGCCATA
GCATCTGATAATGGTGCTGTCCAGCTTCTTGGAATTGAGGCTTCTAAGCTGCCCAAGTCTCCTAAAATCCATCCTCTACAAAGCAGAATT
CTAGATCAGAAGGAGGACGGTTGTGTTGTGGATATGCATCACTTCAACTCTGGAGCACAGTCTGTTCTTGCCTATGCCACTGTGAATGGC
TCTCTGGTTGGCTGGGACCTTAGGTCTTCAAGCAATGCGTGGACTTTAAAGCATGATTTAAAGTCGGGCCTCATCACTTCCTTTGCTGTG
GACATCCACCAATGCTGGCTCTGCATTGGTACAAGCAGTGGTACCATGGCTTGTTGGGACATGAGGTTCCAGTTGCCAATTTCAAGTCAC
TGTCATCCTTCCAGGGCTCGAATCAGACGCCTCTCAATGCACCCTCTGTATCAGTCCTGGGTGATTGCAGCTGTTCAGGGCAACAACGAA
GTGTCCATGTGGGACATGGAGACTGGTGACAGAAGATTTACTCTCTGGGCCAGCAGTGCACCACCACTTTCTGAATTACAGCCTTCTCCT
CATAGCGTCCATGGTATCTACTGTAGTCCTGCAGATGGAAATCCTATCCTACTAACAGCTGGCTCAGATATGAAAATAAGGTTTTGGGAC
TTGGCTTACCCAGAAAGGTCCTATGTTGTTGCAGGAAGTACTAGTTCCCCATCTGTGTCCTACTACAGGAAAATAATTGAAGGCACTGAA
GTTGTCCAGGAAATTCAGAATAAGCAGAAAGTAGGACCAAGTGATGACACCCCTCGAAGGGGCCCAGAGTCCCTGCCCGTGGGACATCAT
GACATCATCACTGATGTCGCCACATTCCAGACCACACAGGGCTTCATCGTAACTGCTTCTAGAGATGGGATTGTGAAGGTGTGGAAATAA
AACCTACTGATTTGTATAAATTTTAATAGTTATAAATATAATACTATAACTCGAGAAAAGGCATTTCTAGAGAACAGATTCATTTGCTTA
ATTTTCAAAATTATGTCTCCATATTACTGTTTCATGACTGACTGACTAAATGACACCCAAAATGGTTAAGATGTACTTGACTAGTTTACT
TATGCATCTCTTTGCAAGAATCAGCCAGCCAACAATGTCTGGGATTTTTATTGTATATGTTATAGAGGTGAGAAATGTAAAATATGAAAA
TGAATATGTTTATTTTGTATTGAAAAAGATGGTTGAAAAGATGGTTGTAAGCTATTATAGTATAAACACATTTTTGCTATTAAAAATGCT

>28484_28484_5_FAM131A-PIK3R4_FAM131A_chr3_184060648_ENST00000450976_PIK3R4_chr3_130454846_ENST00000356763_length(amino acids)=1344AA_BP=230
MQGDGPRPERRLACLGARPWAVSALGARRVRHFWGPTAGRGSGIETAAPAKVSSDPAWAVEWIELPRGLSLSSLGSARTLRGWSRSSRPS
SVDSQDLPEVNVGDTVAMLPKSRRALTIQEIAALARSSLHGISQVVKDHVTKPTAMAQGRVAHLIEWKGWSKPSDSPAALESAFSSYSDL
SEGEQEARFAAGVAEQFAIAEAKLRAWSSVDGEDSTDDSYDEDFAGGMDTGCVIAELFTEGVPLFDLSQLLAYRNGHFFPEQVLNKIEDH
SIRELVTQMIHREPDKRLEAEDYLKQQRGNAFPEIFYTFLQPYMAQFAKETFLSADERILVIRKDLGNIIHNLCGHDLPEKAEGEPKENG
LVILVSVITSCLQTLKYCDSKLAALELILHLAPRLSVEILLDRITPYLLHFSNDSVPRVRAEALRTLTKVLALVKEVPRNDINIYPEYIL
PGIAHLAQDDATIVRLAYAENIALLAETALRFLELVQLKNLNMENDPNNEEIDEVTHPNGNYDTELQALHEMVQQKVVTLLSDPENIVKQ
TLMENGITRLCVFFGRQKANDVLLSHMITFLNDKNDWHLRGAFFDSIVGVAAYVGWQSSSILKPLLQQGLSDAEEFVIVKALYALTCMCQ
LGLLQKPHVYEFASDIAPFLCHPNLWIRYGAVGFITVVARQISTADVYCKLMPYLDPYITQPIIQIERKLVLLSVLKEPVSRSIFDYALR
SKDITSLFRHLHMRQKKRNGSLPDCPPPEDPAIAQLLKKLLSQGMTEEEEDKLLALKDFMMKSNKAKANIVDQSHLHDSSQKGVIDLAAL
GITGRQVDLVKTKQEPDDKRARKHVKQDSNVNEEWKSMFGSLDPPNMPQALPKGSDQEVIQTGKPPRSESSAGICVPLSTSSQVPEVTTV
QNKKPVIPVLSSTILPSTYQIRITTCKTELQQLIQQKREQCNAERIAKQMMENAEWESKPPPPGWRPKGLLVAHLHEHKSAVNRIRVSDE
HSLFATCSNDGTVKIWNSQKMEGKTTTTRSILTYSRIGGRVKTLTFCQGSHYLAIASDNGAVQLLGIEASKLPKSPKIHPLQSRILDQKE
DGCVVDMHHFNSGAQSVLAYATVNGSLVGWDLRSSSNAWTLKHDLKSGLITSFAVDIHQCWLCIGTSSGTMACWDMRFQLPISSHCHPSR
ARIRRLSMHPLYQSWVIAAVQGNNEVSMWDMETGDRRFTLWASSAPPLSELQPSPHSVHGIYCSPADGNPILLTAGSDMKIRFWDLAYPE

--------------------------------------------------------------
>28484_28484_6_FAM131A-PIK3R4_FAM131A_chr3_184060648_ENST00000453072_PIK3R4_chr3_130454846_ENST00000356763_length(transcript)=4270nt_BP=546nt
CCGCAGCTGCGCGGAGCGCCGGGCACGGATGGCGGCGGCTGAGGGGAGCGAAGCGAGGGAGGGAGAGCAAGCTAAGAAACACCCAGCAGG
TGCTCCCCCGCCTAGGCCTGGCTGGAGGCTACTGGCGCCACCCTGGGGGCCCTGTCAGCCAGGTGAATGTTGGAGACACAGTCGCGATGC
TGCCCAAGTCCCGGCGAGCCCTAACTATCCAGGAGATCGCTGCGCTGGCCAGGTCCTCCCTGCATGGTATTTCCCAGGTGGTGAAGGACC
ACGTGACCAAGCCTACCGCCATGGCCCAGGGCCGAGTGGCTCACCTCATTGAGTGGAAGGGCTGGAGCAAGCCGAGTGACTCACCTGCTG
CCCTGGAATCAGCCTTTTCCTCCTATTCAGACCTCAGCGAGGGCGAACAAGAGGCTCGCTTTGCAGCAGGAGTGGCTGAGCAGTTTGCCA
TCGCGGAAGCCAAGCTCCGAGCATGGTCTTCGGTGGATGGCGAGGACTCCACTGATGACTCCTATGATGAGGACTTTGCTGGGGGAATGG
ACACAGGTTGTGTGATAGCTGAGCTTTTTACAGAAGGTGTACCATTATTTGATCTCTCTCAACTTTTGGCTTATAGAAATGGACATTTTT
TCCCTGAACAAGTGCTAAATAAAATTGAAGATCACAGTATCAGAGAATTGGTAACTCAGATGATTCACCGTGAGCCAGATAAACGTTTAG
AGGCAGAAGATTACTTAAAACAGCAGCGTGGCAATGCCTTTCCTGAAATATTTTACACTTTTCTTCAGCCCTACATGGCCCAGTTTGCCA
AGGAAACGTTTCTTTCTGCAGATGAGCGTATTCTGGTTATACGGAAGGATTTGGGCAACATTATTCACAATCTCTGTGGACATGATCTGC
CAGAAAAAGCCGAAGGAGAGCCTAAGGAAAATGGGCTGGTTATCTTGGTATCTGTTATAACATCCTGCCTACAGACCCTTAAATACTGTG
ATTCCAAACTAGCTGCTTTGGAACTGATTCTTCATTTGGCTCCAAGATTAAGTGTTGAAATCCTTTTGGATCGTATTACTCCATATCTTT
TGCATTTCAGCAATGACTCTGTTCCTAGGGTGAGGGCTGAAGCCTTGAGGACGTTGACCAAAGTTCTTGCTCTCGTCAAAGAGGTTCCTC
GTAATGATATCAATATTTATCCGGAATACATTCTGCCAGGCATAGCCCACTTAGCCCAAGATGATGCTACTATCGTTAGACTAGCCTATG
CTGAAAACATAGCTCTGCTGGCAGAAACAGCTCTGAGATTCCTGGAATTAGTACAGTTAAAAAATCTTAATATGGAAAATGACCCCAATA
ATGAAGAAATAGATGAGGTTACACATCCAAATGGAAATTATGACACAGAGCTCCAAGCCTTACATGAAATGGTCCAGCAGAAAGTTGTTA
CTTTGCTAAGTGACCCTGAAAATATTGTAAAACAAACCTTGATGGAAAATGGAATAACACGGCTGTGTGTATTCTTTGGACGTCAGAAAG
CCAACGATGTTTTGTTGTCCCACATGATTACTTTCCTAAATGATAAGAATGATTGGCATCTACGTGGAGCATTTTTTGATAGTATAGTTG
GTGTTGCTGCCTATGTTGGCTGGCAAAGCTCCTCAATTCTCAAGCCTCTGCTGCAACAAGGTCTTAGTGATGCTGAGGAATTTGTCATTG
TGAAAGCTCTTTATGCCCTTACTTGTATGTGCCAGTTAGGACTGCTACAAAAACCCCATGTTTACGAATTTGCCAGTGATATTGCCCCCT
TCCTGTGTCATCCCAATTTATGGATACGTTATGGTGCCGTGGGATTTATCACAGTGGTAGCTCGTCAAATAAGTACAGCTGATGTCTACT
GTAAACTGATGCCTTATCTTGACCCATATATTACCCAACCAATAATACAGATTGAAAGAAAACTTGTTCTGCTCAGTGTTTTAAAGGAAC
CAGTAAGTCGTTCTATATTTGATTATGCTTTGAGGTCTAAAGATATTACTAGCTTGTTCAGACATCTTCACATGCGTCAGAAGAAACGAA
ATGGTTCTCTTCCCGACTGCCCTCCGCCAGAGGATCCTGCCATAGCACAGCTTCTGAAGAAGTTGCTCTCACAGGGAATGACAGAGGAAG
AGGAAGACAAACTTCTGGCACTGAAAGACTTCATGATGAAATCTAATAAAGCAAAGGCCAATATAGTGGACCAGAGCCATCTTCATGATA
GTAGTCAGAAAGGTGTAATTGACTTGGCAGCTTTAGGCATAACTGGGAGACAAGTTGATCTTGTTAAAACCAAACAAGAACCAGATGACA
AACGGGCCAGAAAACATGTAAAACAAGACTCAAATGTAAATGAAGAATGGAAAAGCATGTTTGGGTCACTGGACCCACCAAACATGCCAC
AGGCCCTACCTAAAGGGAGTGATCAGGAGGTGATTCAGACTGGGAAACCTCCTCGTTCCGAGTCCTCTGCTGGCATTTGTGTCCCTTTGT
CAACTTCTTCACAGGTTCCAGAAGTGACAACTGTCCAAAATAAAAAACCAGTAATACCGGTTTTAAGTAGTACAATCTTACCATCCACCT
ATCAGATTCGAATTACAACTTGTAAAACTGAACTTCAGCAACTCATCCAGCAAAAGCGGGAGCAGTGCAATGCTGAGAGAATAGCTAAGC
AGATGATGGAAAATGCTGAATGGGAGAGTAAACCACCACCACCTGGATGGCGTCCTAAAGGGCTGTTAGTTGCCCATCTTCATGAGCATA
AATCTGCTGTGAATCGAATTAGAGTCTCTGATGAACACTCACTTTTTGCAACATGTTCAAATGATGGCACAGTGAAAATCTGGAACAGTC
AAAAGATGGAGGGGAAGACCACCACTACCAGATCTATTCTTACATACAGCCGAATTGGAGGACGAGTCAAGACGCTCACATTCTGCCAAG
GCTCCCACTATTTAGCCATAGCATCTGATAATGGTGCTGTCCAGCTTCTTGGAATTGAGGCTTCTAAGCTGCCCAAGTCTCCTAAAATCC
ATCCTCTACAAAGCAGAATTCTAGATCAGAAGGAGGACGGTTGTGTTGTGGATATGCATCACTTCAACTCTGGAGCACAGTCTGTTCTTG
CCTATGCCACTGTGAATGGCTCTCTGGTTGGCTGGGACCTTAGGTCTTCAAGCAATGCGTGGACTTTAAAGCATGATTTAAAGTCGGGCC
TCATCACTTCCTTTGCTGTGGACATCCACCAATGCTGGCTCTGCATTGGTACAAGCAGTGGTACCATGGCTTGTTGGGACATGAGGTTCC
AGTTGCCAATTTCAAGTCACTGTCATCCTTCCAGGGCTCGAATCAGACGCCTCTCAATGCACCCTCTGTATCAGTCCTGGGTGATTGCAG
CTGTTCAGGGCAACAACGAAGTGTCCATGTGGGACATGGAGACTGGTGACAGAAGATTTACTCTCTGGGCCAGCAGTGCACCACCACTTT
CTGAATTACAGCCTTCTCCTCATAGCGTCCATGGTATCTACTGTAGTCCTGCAGATGGAAATCCTATCCTACTAACAGCTGGCTCAGATA
TGAAAATAAGGTTTTGGGACTTGGCTTACCCAGAAAGGTCCTATGTTGTTGCAGGAAGTACTAGTTCCCCATCTGTGTCCTACTACAGGA
AAATAATTGAAGGCACTGAAGTTGTCCAGGAAATTCAGAATAAGCAGAAAGTAGGACCAAGTGATGACACCCCTCGAAGGGGCCCAGAGT
CCCTGCCCGTGGGACATCATGACATCATCACTGATGTCGCCACATTCCAGACCACACAGGGCTTCATCGTAACTGCTTCTAGAGATGGGA
TTGTGAAGGTGTGGAAATAAAACCTACTGATTTGTATAAATTTTAATAGTTATAAATATAATACTATAACTCGAGAAAAGGCATTTCTAG
AGAACAGATTCATTTGCTTAATTTTCAAAATTATGTCTCCATATTACTGTTTCATGACTGACTGACTAAATGACACCCAAAATGGTTAAG
ATGTACTTGACTAGTTTACTTATGCATCTCTTTGCAAGAATCAGCCAGCCAACAATGTCTGGGATTTTTATTGTATATGTTATAGAGGTG
AGAAATGTAAAATATGAAAATGAATATGTTTATTTTGTATTGAAAAAGATGGTTGAAAAGATGGTTGTAAGCTATTATAGTATAAACACA

>28484_28484_6_FAM131A-PIK3R4_FAM131A_chr3_184060648_ENST00000453072_PIK3R4_chr3_130454846_ENST00000356763_length(amino acids)=1283AA_BP=169
MRGAKRGRESKLRNTQQVLPRLGLAGGYWRHPGGPVSQVNVGDTVAMLPKSRRALTIQEIAALARSSLHGISQVVKDHVTKPTAMAQGRV
AHLIEWKGWSKPSDSPAALESAFSSYSDLSEGEQEARFAAGVAEQFAIAEAKLRAWSSVDGEDSTDDSYDEDFAGGMDTGCVIAELFTEG
VPLFDLSQLLAYRNGHFFPEQVLNKIEDHSIRELVTQMIHREPDKRLEAEDYLKQQRGNAFPEIFYTFLQPYMAQFAKETFLSADERILV
IRKDLGNIIHNLCGHDLPEKAEGEPKENGLVILVSVITSCLQTLKYCDSKLAALELILHLAPRLSVEILLDRITPYLLHFSNDSVPRVRA
EALRTLTKVLALVKEVPRNDINIYPEYILPGIAHLAQDDATIVRLAYAENIALLAETALRFLELVQLKNLNMENDPNNEEIDEVTHPNGN
YDTELQALHEMVQQKVVTLLSDPENIVKQTLMENGITRLCVFFGRQKANDVLLSHMITFLNDKNDWHLRGAFFDSIVGVAAYVGWQSSSI
LKPLLQQGLSDAEEFVIVKALYALTCMCQLGLLQKPHVYEFASDIAPFLCHPNLWIRYGAVGFITVVARQISTADVYCKLMPYLDPYITQ
PIIQIERKLVLLSVLKEPVSRSIFDYALRSKDITSLFRHLHMRQKKRNGSLPDCPPPEDPAIAQLLKKLLSQGMTEEEEDKLLALKDFMM
KSNKAKANIVDQSHLHDSSQKGVIDLAALGITGRQVDLVKTKQEPDDKRARKHVKQDSNVNEEWKSMFGSLDPPNMPQALPKGSDQEVIQ
TGKPPRSESSAGICVPLSTSSQVPEVTTVQNKKPVIPVLSSTILPSTYQIRITTCKTELQQLIQQKREQCNAERIAKQMMENAEWESKPP
PPGWRPKGLLVAHLHEHKSAVNRIRVSDEHSLFATCSNDGTVKIWNSQKMEGKTTTTRSILTYSRIGGRVKTLTFCQGSHYLAIASDNGA
VQLLGIEASKLPKSPKIHPLQSRILDQKEDGCVVDMHHFNSGAQSVLAYATVNGSLVGWDLRSSSNAWTLKHDLKSGLITSFAVDIHQCW
LCIGTSSGTMACWDMRFQLPISSHCHPSRARIRRLSMHPLYQSWVIAAVQGNNEVSMWDMETGDRRFTLWASSAPPLSELQPSPHSVHGI
YCSPADGNPILLTAGSDMKIRFWDLAYPERSYVVAGSTSSPSVSYYRKIIEGTEVVQEIQNKQKVGPSDDTPRRGPESLPVGHHDIITDV

--------------------------------------------------------------

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Fusion Gene PPI Analysis for FAM131A-PIK3R4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FAM131A-PIK3R4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FAM131A-PIK3R4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource