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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:FAM134C-KIAA0100 (FusionGDB2 ID:28508)

Fusion Gene Summary for FAM134C-KIAA0100

Fusion gene summary

Fusion gene information	Fusion gene name: FAM134C-KIAA0100
	Fusion gene ID: 28508
		Hgene	Tgene
	Gene symbol	FAM134C	KIAA0100
	Gene ID	162427	9703
	Gene name	reticulophagy regulator family member 3	KIAA0100
	Synonyms	FAM134C	BCOX\|BCOX1\|CT101\|FMP27
	Cytomap	17q21.2	17q11.2
	Type of gene	protein-coding	protein-coding
	Description	reticulophagy regulator 3family with sequence similarity 134 member Cprotein FAM134C	protein KIAA0100U937-associated antigenantigen MLAA-22breast cancer overexpressed gene 1breast cancer-overexpressed gene 1 proteincancer/testis antigen 101
	Modification date	20200327	20200320
	UniProtAcc	.	Q14667
	Ensembl transtripts involved in fusion gene	ENST00000309428, ENST00000543197, ENST00000585894,	ENST00000579924, ENST00000389003, ENST00000528896, ENST00000544884,
Fusion gene scores	* DoF score	10 X 11 X 6=660	5 X 5 X 3=75
	# samples	13	5
	** MAII score	log2(13/660*10)=-2.34395440121736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: FAM134C [Title/Abstract] AND KIAA0100 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	FAM134C(40761104)-KIAA0100(26965112), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across FAM134C (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across KIAA0100 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	SARC	TCGA-DX-A48N-01A	FAM134C	chr17	40761104	-	KIAA0100	chr17	26965112	-

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Fusion Gene ORF analysis for FAM134C-KIAA0100

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000309428	ENST00000579924	FAM134C	chr17	40761104	-	KIAA0100	chr17	26965112	-
5UTR-3CDS	ENST00000543197	ENST00000389003	FAM134C	chr17	40761104	-	KIAA0100	chr17	26965112	-
5UTR-3CDS	ENST00000543197	ENST00000528896	FAM134C	chr17	40761104	-	KIAA0100	chr17	26965112	-
5UTR-3CDS	ENST00000543197	ENST00000544884	FAM134C	chr17	40761104	-	KIAA0100	chr17	26965112	-
5UTR-intron	ENST00000543197	ENST00000579924	FAM134C	chr17	40761104	-	KIAA0100	chr17	26965112	-
In-frame	ENST00000309428	ENST00000389003	FAM134C	chr17	40761104	-	KIAA0100	chr17	26965112	-
In-frame	ENST00000309428	ENST00000528896	FAM134C	chr17	40761104	-	KIAA0100	chr17	26965112	-
In-frame	ENST00000309428	ENST00000544884	FAM134C	chr17	40761104	-	KIAA0100	chr17	26965112	-
intron-3CDS	ENST00000585894	ENST00000389003	FAM134C	chr17	40761104	-	KIAA0100	chr17	26965112	-
intron-3CDS	ENST00000585894	ENST00000528896	FAM134C	chr17	40761104	-	KIAA0100	chr17	26965112	-
intron-3CDS	ENST00000585894	ENST00000544884	FAM134C	chr17	40761104	-	KIAA0100	chr17	26965112	-
intron-intron	ENST00000585894	ENST00000579924	FAM134C	chr17	40761104	-	KIAA0100	chr17	26965112	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000309428	FAM134C	chr17	40761104	-	ENST00000528896	KIAA0100	chr17	26965112	-	6119	299	296	5494	1732
ENST00000309428	FAM134C	chr17	40761104	-	ENST00000544884	KIAA0100	chr17	26965112	-	5681	299	296	5494	1732
ENST00000309428	FAM134C	chr17	40761104	-	ENST00000389003	KIAA0100	chr17	26965112	-	5677	299	296	5494	1732

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000309428	ENST00000528896	FAM134C	chr17	40761104	-	KIAA0100	chr17	26965112	-	0.002824976	0.997175
ENST00000309428	ENST00000544884	FAM134C	chr17	40761104	-	KIAA0100	chr17	26965112	-	0.003765586	0.9962345
ENST00000309428	ENST00000389003	FAM134C	chr17	40761104	-	KIAA0100	chr17	26965112	-	0.003791969	0.9962081

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Fusion Genomic Features for FAM134C-KIAA0100

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for FAM134C-KIAA0100

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:40761104/chr17:26965112)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	KIAA0100 Q14667
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: May be involved in membrane trafficking. {ECO:0000250\|UniProtKB:K7VLR4}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

KIAA0100

chr17:40761104

chr17:26965112

ENST00000528896

1813_1885

504

2236.0

Coiled coil

Ontology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

FAM134C

chr17:40761104

chr17:26965112

ENST00000309428

445_450

467.0

Motif

LIR motif

Hgene

FAM134C

chr17:40761104

chr17:26965112

ENST00000309428

164_184

467.0

Transmembrane

Helical

Hgene

FAM134C

chr17:40761104

chr17:26965112

ENST00000309428

187_207

467.0

Transmembrane

Helical

Hgene

FAM134C

chr17:40761104

chr17:26965112

ENST00000309428

81_101

467.0

Transmembrane

Helical

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Fusion Gene Sequence for FAM134C-KIAA0100

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>28508_28508_1_FAM134C-KIAA0100_FAM134C_chr17_40761104_ENST00000309428_KIAA0100_chr17_26965112_ENST00000389003_length(transcript)=5677nt_BP=299nt
AGTTGCTGTTATTGTGACTTGTCGGGCCACGGCCCCGGATGTTGTGGCTGCCGCGGGGAGATGGCTGAGGCCGAAGGGGTTCCCACGACC
CCAGGCCCGGCTTCGGGGTCGACTTTCAGGGGCCGCCGAGATGTGTCAGGCTCCTGGGAGCGGGACCAGCAGGTTGAGGCGGCGCAGCGG
GCCCTGGTGGAGGTGCTGGGGCCTTACGAGCCTCTGCTGAGTCGGGTGCAGGCAGCCCTGGTGTGGGAGCGGCCAGCTAGGAGCGCTCTG
TGGTGCCTGGGGCTGAACGCGGCTTTCTGGGTAGCTATAACCAGCCTCTGGGCCTGTCCAGCACCCAGTCAGATACCCTTTTTCTTGATT
GTACCATTCGAGGACTTCAGGTGGAAGCATCAGATACCTGTGCCCAATGTCTGTCTCGTATCTTATCCCTGATGGGTCCACAATCTGGGA
AGTCAGCTGTCTCTAGGCACTCTTCATTTGGGGAATCTGTGTCATTACTGTGGAAGGTGGACTTGAAGGTCGAAGACATGAACTTGTTTA
CCCTTTCTGCCTTGGTTGGTGCTTCAGAGGTACGACTGGACACCCTAACTATCCTGGGCAGTGCAGAGACGTCCACTGTGGGGATTCAAG
GACTTGTGTTAGCGCTGGTGAAATCAGTCACGGAGAAGATGCAACCCTGTTGCAAGGCCCCTGACATCCCTACCCCAGTGCTCAGCCTTT
CCATGCTCTCCATCACCTATCACAGCAGCATCCGCTCTCTGGAGGTTCAGTGTGGTGCAGGGCTGACCTTACTTTGGAGCCCCCCAGATC
ACATGTACCTGTACCAGCATGTCCTGGCCACTCTACAGTGCCGAGACCTACTAAGAGCCACTGTGTTTCCTGAGACTGTACCATCCCTTG
CACTAGAGACTTCAGGAACTACTTCTGAGCTAGAAGGCCGTGCCCCTGAGCCATTACCCCCAAAGCGGCTGCTAAACCTAACCCTGGAGG
TGAGCACAGCCAAGCTCACAGCTTTTGTAGCTGAGGACAAGTTCATTACCCTGGCTGCAGAGAGTGTGTCACTGAGCCGGCATGGAGGTT
CCCTGCAGGCATACTGTCCAGAGCTGGCTGCTGGCTTTGATGGCAATAGTATCTTCAACTTCAAGGAGGTGGAGGTGCAGCTGCTACCTG
AGCTGGAAGAGATGATCCTCCACCGGAACCCCTTCCCTGCGCTGCAGACCCTCCGGAACCGTGTTTGGCTCCTCTCTTTCGGCTCAGTCT
CGGTGGAGTTTCCTTATCAGTATGACTTTTCTCGAACTCTAGATGAGGCTGTGGGAGTTCAGAAGTGGCTGAAGGGACTACATCAAGGGA
CTCGTGCTTGGGCCTCTCCAAGCCCTGTCCCACTCCCACCTGATCTACTCTTAAAGGTTGAGCACTTCTCATGGGTTTTCTTGGATGATG
TTTTTGAGGTGAAACTTCATGATAACTACGAGCTGATGAAGGATGAAAGTAAGGAGAGTGCCAAAAGACTACAGCTACTGGATGCTAAAG
TGGCCGCCCTTCGGAAGCAGCATGGGGAGTTGTTGCCTGCCCGCAAAATTGAGGAGCTCTATGCCTCTTTGGAACGCAAAAACATTGAAA
TCTACATCCAGCGTTCCCGTCGTCTCTATGGCAACACACCCATGCGCCGGGCACTGCTTACTTGGAGCTTAGCAGGGCTAGAACTGGTAG
CTCTGGCAGATGCCTCCTTCCATGGTCCTGAGCATGTGGTAGAACAGGTTCAAGAGCTTGATCCAGGCAGCCCTTTTCCCCCTGAGGGAT
TAGATCTTGTCATTCAGTGGTGTCGAATGCTCAAGTGCAATGTCAAGAGCTTTCTGGTTCGGATCAGGGACTATCCACGGTACCTGTTTG
AGATCCGTGACTGGCGGCTAATGGGTCGACTTGTGGGCACCGAGCAGAGTGGTCAGCCTTGCTCCCGTCGGCGTCAGATCTTGCACTTGG
GGCTTCCGTGGGGTAACGTGGCAGTGGAGAGGAACATGCCCCCACTCAAATTCTACCATGACTTTCACTCGGAAATATTCCAGTACACAG
TGGTGTGGGGCCCATGCTGGGATCCAGCCTGGACACTAATTGGCCAGTGTGTGGACCTCTTGACCAAGCCCTCAGCTGACCCCAGCCCAC
CTTTGCCCTGGTGGGACAAGAGCCGTCTTCTGTTCCATGGAGACTGGCACATGGACATTGAACAGGCGAACCTGCACCAGCTGGCCACTG
AGGATCCATACAACACAACTGAAAATATGCACTGGGAGTGGAGCCACCTGTCTTTTCATTGGAAACCTGGTCAGTTTGTGTTCAAGGGTG
ACTTGGATATCAACGTGAGAACAGCCTCTAAGTATGACGACTGCTGCTTCCTTCACCTGCCTGACCTCTGCATGACACTGGACCTGCAGT
GGCTGTGCCATGGGAACCCCCATGATCACCATAGTGTCACTCTGCGGGCCCCAGAGTTCCTGCCTGAGGTGCCCTTGGGCCAGCTTCATG
ACTCCTACCGGGCCTTTCGCTCGGAGAACCTCAATCTCTCCATCAAGATGGATCTGACTCGGCACAGTGGAACAATATCCCAGCCCCGAA
TTCTGCTATATAGTAGTACCCTGCGCTGGATGCAAAACTTCTGGGCAACTTGGACAAGTGTCACAAGGCCTATCTGCAGGGGAAAGCTCT
TCAATAACCTGAAACCCAGCAAGAAGAAACTTGGTCAGCACTACAAGCAACTTTCCTATACAGCCCTCTTTCCCCAGCTGCAGGTACATT
ATTGGGCCTCATTTGCCCAGCAACGGGGCATCCAGATTGAGTGCAGTCAGGGCCATGTCTTCACTCGGGGGACTCAGCGGCTTATACCTC
AAGCAGGCACAGTGATGCGGCGCCTTATCTCTGATTGGAGTGTTACCCAGATGGTGAGTGACCTAAGTCAGGTGACCGTTCACCTGATGG
CCTCACCCACTGAAGAGAATGCTGATCACTGTCTTGATCCCTTGGTAACAAAGACCCACCTGCTGAGCTTGTCCTCCCTCACCTACCAAC
GGCATAGCAATCGCACAGCTGAGGAGGAGCTCTCTGCTCGTGATGGGGATCCTACCTTTCATACACATCAGCTGCACTTAGTAGATTTAC
GGATTTCCTGGACAACTACCAATCGAGACATTGCCTTTGGGTTATATGATGGGTACAAAAAGGCAGCTGTACTCAAACGTAATCTTTCTA
CTGAGGCCCTGAAGGGGTTAAAGATTGATCCACAGATGCCAGCCAAAAAGCCAAAGCGGGGTGTCCCAACTAGTGCCTCAGCCCCACCTC
GTGTTAACACTCCCAGCTTCAGTGGACAACCTGATAAGGGGTCATCAGGAGGTGCTTACATGTTGCAGAAGCTAATTGAAGAGACAGATA
GGTTTGTAGTGTTCACAGAAGAGGAATCAGGCATGAGTGACCAGTTGTGTGGCATTGCTGCCTGCCAGACGGATGACATATACAACCGAA
ACTGCCTTATTGAATTGGTCAACTGTCAGATGGTTCTTCGTGGAGCAGAGACAGAAGGCTGTGTCATTGTGTCAGCTGCCAAAGCCCAAC
TGCTGCAGTGCCAGCACCATCCAGCCTGGTATGGTGATACATTGAAGCAAAAGACATCCTGGACTTGCCTCTTGGATGGCATGCAGTACT
TTGCCACCACTGAAAGCAGCCCCACAGAGCAGGATGGCCGACAGCTCTGGTTAGAGGTGAAGAATATCGAGGAGCACCGGCAGCGTAGTC
TGGACTCTGTGCAGGAGCTGATGGAGAGTGGGCAGGCAGTGGGCGGCATGGTTACCACAACCACAGATTGGAACCAGCCAGCTGAGGCAC
AGCAAGCCCAGCAAGTCCAGCGGATCATTTCGCGTTGCAACTGCCGAATGTACTATATTAGTTACAGCCATGACATTGATCCTGAACTAG
CAACTCAGATTAAGCCACCTGAAGTTCTTGAGAACCAGGAAAAGGAAGATCTCCTAAAGAAGCAGGAAGGGGCTGTGGATACCTTCACCC
TTATCCACCATGAGCTGGAAATTTCCACCAACCCAGCTCAGTATGCCATGATCCTGGACATTGTCAACAACCTGCTGCTCCATGTAGAAC
CTAAGCGGAAGGAACATAGTGAGAAGAAGCAACGGGTCAGGTTCCAGCTTGAGATCTCTAGCAATCCAGAGGAGCAACGCAGCAGCATAC
TGCATTTGCAGGAGGCTGTGCGGCAGCATGTGGCCCAAATACGACAGCTGGAGAAGCAGATGTATTCTATCATGAAGTCTTTGCAGGATG
ACAGCAAGAATGAGAATCTGCTTGACCTGAACCAGAAGCTTCAGTTGCAGCTAAACCAGGAGAAGGCCAACCTGCAGCTGGAAAGTGAAG
AACTGAATATCCTCATCAGGTGTTTTAAGGATTTCCAACTGCAGCGGGCTAACAAGATGGAGCTGCGAAAGCAGCAAGAAGATGTGAGTG
TGGTCCGTCGCACTGAGTTTTACTTTGCTCAGGCACGGTGGCGCCTGACAGAGGAAGATGGACAGCTGGGAATTGCTGAATTAGAACTGC
AGAGGTTCCTCTACAGCAAGGTGAATAAGTCTGATGACACAGCAGAACATCTTCTGGAGTTGGGCTGGTTTACCATGAACAACCTCCTCC
CCAATGCTGTCTATAAGGCAATACTGCGGCCCCAGAGCTCCTGCCAGTCTGGGCGACAGCTAGCTCTCCGCCTCTTCAGCAAAGTTCGGC
CCCCTGTTGGGGGTATCTCTGTTAAGGAGCATTTTGAGGTAAATGTGGTGCCTCTCACCATCCAGCTGACACACCAGTTCTTCCACAGAA
TGATGGGCTTTTTCTTTCCTGGCCGAAGTGTGGAAGATGATGAAGTTGGTGATGAAGAGGATAAGTCCAAACTGGTGACTACTGGAATAC
CAGTGGTGAAGCCTCGGCAGCTGATTGCAACAGATGATGCAGTACCACTGGGCCCTGGGAAGGGTGTGGCACAGGGTTTGACTCGGAGTT
CTGGGGTCAGAAGGTCATTTCGCAAATCGCCAGAGCACCCTGTGGATGACATTGACAAGATGAAAGAGCGAGCTGCCATGAACAACTCCT
TCATCTACATAAAGATTCCACAGGTTCCACTGTGTGTCAGCTACAAGGGTGAGAAGAACAGTGTGGACTGGGGTGACCTTAACCTGGTGC
TGCCCTGTCTGGAGTACCACAACAACACATGGACATGGCTAGACTTTGCCATGGCTGTCAAAAGGGACAGCCGCAAAGCCCTGGTTGCCC
AGGTAATCAAAGAGAAGCTAAGGCTGAAGTCTGCAACAGGCTCTGAGGTCCGGGGAAAGCTAGAAACTAAATCGGACCTGAACATGCAAC
AGCAGGAAGAGGAGGAGAAAGCCCGGCTCCTCATTGGTTTAAGTGTGGGCGACAAGAACCCTGGCAAGAAGTCCATCTTTGGCAGGCGCA
AATGATTTGGCGATTCGAGTGGCTGCAGTACAGGATCTGACTCTGGCTCAGGCTCCAGGGACTTGTGGGGTGGGAGGGGCTTCCCGTTAT
CCACGAGGATTTGTGGGTGTCAGAGCCCATAGGCATCACTCTTCAGCACCTGGTCTGTTCGCTGCAGGGCATGGTGGACAGTAATGCTGA

>28508_28508_1_FAM134C-KIAA0100_FAM134C_chr17_40761104_ENST00000309428_KIAA0100_chr17_26965112_ENST00000389003_length(amino acids)=1732AA_BP=1
MGSYNQPLGLSSTQSDTLFLDCTIRGLQVEASDTCAQCLSRILSLMGPQSGKSAVSRHSSFGESVSLLWKVDLKVEDMNLFTLSALVGAS
EVRLDTLTILGSAETSTVGIQGLVLALVKSVTEKMQPCCKAPDIPTPVLSLSMLSITYHSSIRSLEVQCGAGLTLLWSPPDHMYLYQHVL
ATLQCRDLLRATVFPETVPSLALETSGTTSELEGRAPEPLPPKRLLNLTLEVSTAKLTAFVAEDKFITLAAESVSLSRHGGSLQAYCPEL
AAGFDGNSIFNFKEVEVQLLPELEEMILHRNPFPALQTLRNRVWLLSFGSVSVEFPYQYDFSRTLDEAVGVQKWLKGLHQGTRAWASPSP
VPLPPDLLLKVEHFSWVFLDDVFEVKLHDNYELMKDESKESAKRLQLLDAKVAALRKQHGELLPARKIEELYASLERKNIEIYIQRSRRL
YGNTPMRRALLTWSLAGLELVALADASFHGPEHVVEQVQELDPGSPFPPEGLDLVIQWCRMLKCNVKSFLVRIRDYPRYLFEIRDWRLMG
RLVGTEQSGQPCSRRRQILHLGLPWGNVAVERNMPPLKFYHDFHSEIFQYTVVWGPCWDPAWTLIGQCVDLLTKPSADPSPPLPWWDKSR
LLFHGDWHMDIEQANLHQLATEDPYNTTENMHWEWSHLSFHWKPGQFVFKGDLDINVRTASKYDDCCFLHLPDLCMTLDLQWLCHGNPHD
HHSVTLRAPEFLPEVPLGQLHDSYRAFRSENLNLSIKMDLTRHSGTISQPRILLYSSTLRWMQNFWATWTSVTRPICRGKLFNNLKPSKK
KLGQHYKQLSYTALFPQLQVHYWASFAQQRGIQIECSQGHVFTRGTQRLIPQAGTVMRRLISDWSVTQMVSDLSQVTVHLMASPTEENAD
HCLDPLVTKTHLLSLSSLTYQRHSNRTAEEELSARDGDPTFHTHQLHLVDLRISWTTTNRDIAFGLYDGYKKAAVLKRNLSTEALKGLKI
DPQMPAKKPKRGVPTSASAPPRVNTPSFSGQPDKGSSGGAYMLQKLIEETDRFVVFTEEESGMSDQLCGIAACQTDDIYNRNCLIELVNC
QMVLRGAETEGCVIVSAAKAQLLQCQHHPAWYGDTLKQKTSWTCLLDGMQYFATTESSPTEQDGRQLWLEVKNIEEHRQRSLDSVQELME
SGQAVGGMVTTTTDWNQPAEAQQAQQVQRIISRCNCRMYYISYSHDIDPELATQIKPPEVLENQEKEDLLKKQEGAVDTFTLIHHELEIS
TNPAQYAMILDIVNNLLLHVEPKRKEHSEKKQRVRFQLEISSNPEEQRSSILHLQEAVRQHVAQIRQLEKQMYSIMKSLQDDSKNENLLD
LNQKLQLQLNQEKANLQLESEELNILIRCFKDFQLQRANKMELRKQQEDVSVVRRTEFYFAQARWRLTEEDGQLGIAELELQRFLYSKVN
KSDDTAEHLLELGWFTMNNLLPNAVYKAILRPQSSCQSGRQLALRLFSKVRPPVGGISVKEHFEVNVVPLTIQLTHQFFHRMMGFFFPGR
SVEDDEVGDEEDKSKLVTTGIPVVKPRQLIATDDAVPLGPGKGVAQGLTRSSGVRRSFRKSPEHPVDDIDKMKERAAMNNSFIYIKIPQV
PLCVSYKGEKNSVDWGDLNLVLPCLEYHNNTWTWLDFAMAVKRDSRKALVAQVIKEKLRLKSATGSEVRGKLETKSDLNMQQQEEEEKAR

--------------------------------------------------------------
>28508_28508_2_FAM134C-KIAA0100_FAM134C_chr17_40761104_ENST00000309428_KIAA0100_chr17_26965112_ENST00000528896_length(transcript)=6119nt_BP=299nt
AGTTGCTGTTATTGTGACTTGTCGGGCCACGGCCCCGGATGTTGTGGCTGCCGCGGGGAGATGGCTGAGGCCGAAGGGGTTCCCACGACC
CCAGGCCCGGCTTCGGGGTCGACTTTCAGGGGCCGCCGAGATGTGTCAGGCTCCTGGGAGCGGGACCAGCAGGTTGAGGCGGCGCAGCGG
GCCCTGGTGGAGGTGCTGGGGCCTTACGAGCCTCTGCTGAGTCGGGTGCAGGCAGCCCTGGTGTGGGAGCGGCCAGCTAGGAGCGCTCTG
TGGTGCCTGGGGCTGAACGCGGCTTTCTGGGTAGCTATAACCAGCCTCTGGGCCTGTCCAGCACCCAGTCAGATACCCTTTTTCTTGATT
GTACCATTCGAGGACTTCAGGTGGAAGCATCAGATACCTGTGCCCAATGTCTGTCTCGTATCTTATCCCTGATGGGTCCACAATCTGGGA
AGTCAGCTGTCTCTAGGCACTCTTCATTTGGGGAATCTGTGTCATTACTGTGGAAGGTGGACTTGAAGGTCGAAGACATGAACTTGTTTA
CCCTTTCTGCCTTGGTTGGTGCTTCAGAGGTACGACTGGACACCCTAACTATCCTGGGCAGTGCAGAGACGTCCACTGTGGGGATTCAAG
GACTTGTGTTAGCGCTGGTGAAATCAGTCACGGAGAAGATGCAACCCTGTTGCAAGGCCCCTGACATCCCTACCCCAGTGCTCAGCCTTT
CCATGCTCTCCATCACCTATCACAGCAGCATCCGCTCTCTGGAGGTTCAGTGTGGTGCAGGGCTGACCTTACTTTGGAGCCCCCCAGATC
ACATGTACCTGTACCAGCATGTCCTGGCCACTCTACAGTGCCGAGACCTACTAAGAGCCACTGTGTTTCCTGAGACTGTACCATCCCTTG
CACTAGAGACTTCAGGAACTACTTCTGAGCTAGAAGGCCGTGCCCCTGAGCCATTACCCCCAAAGCGGCTGCTAAACCTAACCCTGGAGG
TGAGCACAGCCAAGCTCACAGCTTTTGTAGCTGAGGACAAGTTCATTACCCTGGCTGCAGAGAGTGTGTCACTGAGCCGGCATGGAGGTT
CCCTGCAGGCATACTGTCCAGAGCTGGCTGCTGGCTTTGATGGCAATAGTATCTTCAACTTCAAGGAGGTGGAGGTGCAGCTGCTACCTG
AGCTGGAAGAGATGATCCTCCACCGGAACCCCTTCCCTGCGCTGCAGACCCTCCGGAACCGTGTTTGGCTCCTCTCTTTCGGCTCAGTCT
CGGTGGAGTTTCCTTATCAGTATGACTTTTCTCGAACTCTAGATGAGGCTGTGGGAGTTCAGAAGTGGCTGAAGGGACTACATCAAGGGA
CTCGTGCTTGGGCCTCTCCAAGCCCTGTCCCACTCCCACCTGATCTACTCTTAAAGGTTGAGCACTTCTCATGGGTTTTCTTGGATGATG
TTTTTGAGGTGAAACTTCATGATAACTACGAGCTGATGAAGGATGAAAGTAAGGAGAGTGCCAAAAGACTACAGCTACTGGATGCTAAAG
TGGCCGCCCTTCGGAAGCAGCATGGGGAGTTGTTGCCTGCCCGCAAAATTGAGGAGCTCTATGCCTCTTTGGAACGCAAAAACATTGAAA
TCTACATCCAGCGTTCCCGTCGTCTCTATGGCAACACACCCATGCGCCGGGCACTGCTTACTTGGAGCTTAGCAGGGCTAGAACTGGTAG
CTCTGGCAGATGCCTCCTTCCATGGTCCTGAGCATGTGGTAGAACAGGTTCAAGAGCTTGATCCAGGCAGCCCTTTTCCCCCTGAGGGAT
TAGATCTTGTCATTCAGTGGTGTCGAATGCTCAAGTGCAATGTCAAGAGCTTTCTGGTTCGGATCAGGGACTATCCACGGTACCTGTTTG
AGATCCGTGACTGGCGGCTAATGGGTCGACTTGTGGGCACCGAGCAGAGTGGTCAGCCTTGCTCCCGTCGGCGTCAGATCTTGCACTTGG
GGCTTCCGTGGGGTAACGTGGCAGTGGAGAGGAACATGCCCCCACTCAAATTCTACCATGACTTTCACTCGGAAATATTCCAGTACACAG
TGGTGTGGGGCCCATGCTGGGATCCAGCCTGGACACTAATTGGCCAGTGTGTGGACCTCTTGACCAAGCCCTCAGCTGACCCCAGCCCAC
CTTTGCCCTGGTGGGACAAGAGCCGTCTTCTGTTCCATGGAGACTGGCACATGGACATTGAACAGGCGAACCTGCACCAGCTGGCCACTG
AGGATCCATACAACACAACTGAAAATATGCACTGGGAGTGGAGCCACCTGTCTTTTCATTGGAAACCTGGTCAGTTTGTGTTCAAGGGTG
ACTTGGATATCAACGTGAGAACAGCCTCTAAGTATGACGACTGCTGCTTCCTTCACCTGCCTGACCTCTGCATGACACTGGACCTGCAGT
GGCTGTGCCATGGGAACCCCCATGATCACCATAGTGTCACTCTGCGGGCCCCAGAGTTCCTGCCTGAGGTGCCCTTGGGCCAGCTTCATG
ACTCCTACCGGGCCTTTCGCTCGGAGAACCTCAATCTCTCCATCAAGATGGATCTGACTCGGCACAGTGGAACAATATCCCAGCCCCGAA
TTCTGCTATATAGTAGTACCCTGCGCTGGATGCAAAACTTCTGGGCAACTTGGACAAGTGTCACAAGGCCTATCTGCAGGGGAAAGCTCT
TCAATAACCTGAAACCCAGCAAGAAGAAACTTGGTCAGCACTACAAGCAACTTTCCTATACAGCCCTCTTTCCCCAGCTGCAGGTACATT
ATTGGGCCTCATTTGCCCAGCAACGGGGCATCCAGATTGAGTGCAGTCAGGGCCATGTCTTCACTCGGGGGACTCAGCGGCTTATACCTC
AAGCAGGCACAGTGATGCGGCGCCTTATCTCTGATTGGAGTGTTACCCAGATGGTGAGTGACCTAAGTCAGGTGACCGTTCACCTGATGG
CCTCACCCACTGAAGAGAATGCTGATCACTGTCTTGATCCCTTGGTAACAAAGACCCACCTGCTGAGCTTGTCCTCCCTCACCTACCAAC
GGCATAGCAATCGCACAGCTGAGGAGGAGCTCTCTGCTCGTGATGGGGATCCTACCTTTCATACACATCAGCTGCACTTAGTAGATTTAC
GGATTTCCTGGACAACTACCAATCGAGACATTGCCTTTGGGTTATATGATGGGTACAAAAAGGCAGCTGTACTCAAACGTAATCTTTCTA
CTGAGGCCCTGAAGGGGTTAAAGATTGATCCACAGATGCCAGCCAAAAAGCCAAAGCGGGGTGTCCCAACTAGTGCCTCAGCCCCACCTC
GTGTTAACACTCCCAGCTTCAGTGGACAACCTGATAAGGGGTCATCAGGAGGTGCTTACATGTTGCAGAAGCTAATTGAAGAGACAGATA
GGTTTGTAGTGTTCACAGAAGAGGAATCAGGCATGAGTGACCAGTTGTGTGGCATTGCTGCCTGCCAGACGGATGACATATACAACCGAA
ACTGCCTTATTGAATTGGTCAACTGTCAGATGGTTCTTCGTGGAGCAGAGACAGAAGGCTGTGTCATTGTGTCAGCTGCCAAAGCCCAAC
TGCTGCAGTGCCAGCACCATCCAGCCTGGTATGGTGATACATTGAAGCAAAAGACATCCTGGACTTGCCTCTTGGATGGCATGCAGTACT
TTGCCACCACTGAAAGCAGCCCCACAGAGCAGGATGGCCGACAGCTCTGGTTAGAGGTGAAGAATATCGAGGAGCACCGGCAGCGTAGTC
TGGACTCTGTGCAGGAGCTGATGGAGAGTGGGCAGGCAGTGGGCGGCATGGTTACCACAACCACAGATTGGAACCAGCCAGCTGAGGCAC
AGCAAGCCCAGCAAGTCCAGCGGATCATTTCGCGTTGCAACTGCCGAATGTACTATATTAGTTACAGCCATGACATTGATCCTGAACTAG
CAACTCAGATTAAGCCACCTGAAGTTCTTGAGAACCAGGAAAAGGAAGATCTCCTAAAGAAGCAGGAAGGGGCTGTGGATACCTTCACCC
TTATCCACCATGAGCTGGAAATTTCCACCAACCCAGCTCAGTATGCCATGATCCTGGACATTGTCAACAACCTGCTGCTCCATGTAGAAC
CTAAGCGGAAGGAACATAGTGAGAAGAAGCAACGGGTCAGGTTCCAGCTTGAGATCTCTAGCAATCCAGAGGAGCAACGCAGCAGCATAC
TGCATTTGCAGGAGGCTGTGCGGCAGCATGTGGCCCAAATACGACAGCTGGAGAAGCAGATGTATTCTATCATGAAGTCTTTGCAGGATG
ACAGCAAGAATGAGAATCTGCTTGACCTGAACCAGAAGCTTCAGTTGCAGCTAAACCAGGAGAAGGCCAACCTGCAGCTGGAAAGTGAAG
AACTGAATATCCTCATCAGGTGTTTTAAGGATTTCCAACTGCAGCGGGCTAACAAGATGGAGCTGCGAAAGCAGCAAGAAGATGTGAGTG
TGGTCCGTCGCACTGAGTTTTACTTTGCTCAGGCACGGTGGCGCCTGACAGAGGAAGATGGACAGCTGGGAATTGCTGAATTAGAACTGC
AGAGGTTCCTCTACAGCAAGGTGAATAAGTCTGATGACACAGCAGAACATCTTCTGGAGTTGGGCTGGTTTACCATGAACAACCTCCTCC
CCAATGCTGTCTATAAGGTAGTACTGCGGCCCCAGAGCTCCTGCCAGTCTGGGCGACAGCTAGCTCTCCGCCTCTTCAGCAAAGTTCGGC
CCCCTGTTGGGGGTATCTCTGTTAAGGAGCATTTTGAGGTAAATGTGGTGCCTCTCACCATCCAGCTGACACACCAGTTCTTCCACAGAA
TGATGGGCTTTTTCTTTCCTGGCCGAAGTGTGGAAGATGATGAAGTTGGTGATGAAGAGGATAAGTCCAAACTGGTGACTACTGGAATAC
CAGTGGTGAAGCCTCGGCAGCTGATTGCAACAGATGATGCAGTACCACTGGGCCCTGGGAAGGGTGTGGCACAGGGTTTGACTCGGAGTT
CTGGGGTCAGAAGGTCATTTCGCAAATCGCCAGAGCACCCTGTGGATGACATTGACAAGATGAAAGAGCGAGCTGCCATGAACAACTCCT
TCATCTACATAAAGATTCCACAGGTTCCACTGTGTGTCAGCTACAAGGGTGAGAAGAACAGTGTGGACTGGGGTGACCTTAACCTGGTGC
TGCCCTGTCTGGAGTACCACAACAACACATGGACATGGCTAGACTTTGCCATGGCTGTCAAAAGGGACAGCCGCAAAGCCCTGGTTGCCC
AGGTAATCAAAGAGAAGCTAAGGCTGAAGTCTGCAACAGGCTCTGAGGTCCGGGGAAAGCTAGAAACTAAATCGGACCTGAACATGCAAC
AGCAGGAAGAGGAGGAGAAAGCCCGGCTCCTCATTGGTTTAAGTGTGGGCGACAAGAACCCTGGCAAGAAGTCCATCTTTGGCAGGCGCA
AATGATTTGGCGATTCGAGTGGCTGCAGTACAGGATCTGACTCTGGCTCAGGCTCCAGGGACTTGTGGGGTGGGAGGGGCTTCCCGTTAT
CCACGAGGATTTGTGGGTGTCAGAGCCCATAGGCATCACTCTTCAGCACCTGGTCTGTTCGCTGCAGGGCATGGTGGACAGTAATGCTGA
GTTCTGTCTCACACTGATCAGGCTCAGGGCCAGAGAGGCAACAAGAGAGCAAGACCCAGGGAATGGGCCCAGGGCAGGACCCTATTCCCT
TGGGGTCAAGTGAAAGGGTAGGGGGATAGTCCTGATCAAGTGTGATAAATTTTTATAGACATATATAAATATATATATATTATATATATA
TTTCTAAGTGTAACTGTCCTTCCTCTGTGCCAGGAAACGGGAGGGGGCTGATCCTCTGATCCTCACTCCACTGTCATGTTTGAAAGAGGT
ATTGGTGTTCTGGAGTGGGGGTCAACCCCTCCCCAGTCTCTGTGCTAAGTTCACTTGGGAGGATGGCAGTAGGAGCCAGGGCTGGCCATG

>28508_28508_2_FAM134C-KIAA0100_FAM134C_chr17_40761104_ENST00000309428_KIAA0100_chr17_26965112_ENST00000528896_length(amino acids)=1732AA_BP=1
MGSYNQPLGLSSTQSDTLFLDCTIRGLQVEASDTCAQCLSRILSLMGPQSGKSAVSRHSSFGESVSLLWKVDLKVEDMNLFTLSALVGAS
EVRLDTLTILGSAETSTVGIQGLVLALVKSVTEKMQPCCKAPDIPTPVLSLSMLSITYHSSIRSLEVQCGAGLTLLWSPPDHMYLYQHVL
ATLQCRDLLRATVFPETVPSLALETSGTTSELEGRAPEPLPPKRLLNLTLEVSTAKLTAFVAEDKFITLAAESVSLSRHGGSLQAYCPEL
AAGFDGNSIFNFKEVEVQLLPELEEMILHRNPFPALQTLRNRVWLLSFGSVSVEFPYQYDFSRTLDEAVGVQKWLKGLHQGTRAWASPSP
VPLPPDLLLKVEHFSWVFLDDVFEVKLHDNYELMKDESKESAKRLQLLDAKVAALRKQHGELLPARKIEELYASLERKNIEIYIQRSRRL
YGNTPMRRALLTWSLAGLELVALADASFHGPEHVVEQVQELDPGSPFPPEGLDLVIQWCRMLKCNVKSFLVRIRDYPRYLFEIRDWRLMG
RLVGTEQSGQPCSRRRQILHLGLPWGNVAVERNMPPLKFYHDFHSEIFQYTVVWGPCWDPAWTLIGQCVDLLTKPSADPSPPLPWWDKSR
LLFHGDWHMDIEQANLHQLATEDPYNTTENMHWEWSHLSFHWKPGQFVFKGDLDINVRTASKYDDCCFLHLPDLCMTLDLQWLCHGNPHD
HHSVTLRAPEFLPEVPLGQLHDSYRAFRSENLNLSIKMDLTRHSGTISQPRILLYSSTLRWMQNFWATWTSVTRPICRGKLFNNLKPSKK
KLGQHYKQLSYTALFPQLQVHYWASFAQQRGIQIECSQGHVFTRGTQRLIPQAGTVMRRLISDWSVTQMVSDLSQVTVHLMASPTEENAD
HCLDPLVTKTHLLSLSSLTYQRHSNRTAEEELSARDGDPTFHTHQLHLVDLRISWTTTNRDIAFGLYDGYKKAAVLKRNLSTEALKGLKI
DPQMPAKKPKRGVPTSASAPPRVNTPSFSGQPDKGSSGGAYMLQKLIEETDRFVVFTEEESGMSDQLCGIAACQTDDIYNRNCLIELVNC
QMVLRGAETEGCVIVSAAKAQLLQCQHHPAWYGDTLKQKTSWTCLLDGMQYFATTESSPTEQDGRQLWLEVKNIEEHRQRSLDSVQELME
SGQAVGGMVTTTTDWNQPAEAQQAQQVQRIISRCNCRMYYISYSHDIDPELATQIKPPEVLENQEKEDLLKKQEGAVDTFTLIHHELEIS
TNPAQYAMILDIVNNLLLHVEPKRKEHSEKKQRVRFQLEISSNPEEQRSSILHLQEAVRQHVAQIRQLEKQMYSIMKSLQDDSKNENLLD
LNQKLQLQLNQEKANLQLESEELNILIRCFKDFQLQRANKMELRKQQEDVSVVRRTEFYFAQARWRLTEEDGQLGIAELELQRFLYSKVN
KSDDTAEHLLELGWFTMNNLLPNAVYKVVLRPQSSCQSGRQLALRLFSKVRPPVGGISVKEHFEVNVVPLTIQLTHQFFHRMMGFFFPGR
SVEDDEVGDEEDKSKLVTTGIPVVKPRQLIATDDAVPLGPGKGVAQGLTRSSGVRRSFRKSPEHPVDDIDKMKERAAMNNSFIYIKIPQV
PLCVSYKGEKNSVDWGDLNLVLPCLEYHNNTWTWLDFAMAVKRDSRKALVAQVIKEKLRLKSATGSEVRGKLETKSDLNMQQQEEEEKAR

--------------------------------------------------------------
>28508_28508_3_FAM134C-KIAA0100_FAM134C_chr17_40761104_ENST00000309428_KIAA0100_chr17_26965112_ENST00000544884_length(transcript)=5681nt_BP=299nt
AGTTGCTGTTATTGTGACTTGTCGGGCCACGGCCCCGGATGTTGTGGCTGCCGCGGGGAGATGGCTGAGGCCGAAGGGGTTCCCACGACC
CCAGGCCCGGCTTCGGGGTCGACTTTCAGGGGCCGCCGAGATGTGTCAGGCTCCTGGGAGCGGGACCAGCAGGTTGAGGCGGCGCAGCGG
GCCCTGGTGGAGGTGCTGGGGCCTTACGAGCCTCTGCTGAGTCGGGTGCAGGCAGCCCTGGTGTGGGAGCGGCCAGCTAGGAGCGCTCTG
TGGTGCCTGGGGCTGAACGCGGCTTTCTGGGTAGCTATAACCAGCCTCTGGGCCTGTCCAGCACCCAGTCAGATACCCTTTTTCTTGATT
GTACCATTCGAGGACTTCAGGTGGAAGCATCAGATACCTGTGCCCAATGTCTGTCTCGTATCTTATCCCTGATGGGTCCACAATCTGGGA
AGTCAGCTGTCTCTAGGCACTCTTCATTTGGGGAATCTGTGTCATTACTGTGGAAGGTGGACTTGAAGGTCGAAGACATGAACTTGTTTA
CCCTTTCTGCCTTGGTTGGTGCTTCAGAGGTACGACTGGACACCCTAACTATCCTGGGCAGTGCAGAGACGTCCACTGTGGGGATTCAAG
GACTTGTGTTAGCGCTGGTGAAATCAGTCACGGAGAAGATGCAACCCTGTTGCAAGGCCCCTGACATCCCTACCCCAGTGCTCAGCCTTT
CCATGCTCTCCATCACCTATCACAGCAGCATCCGCTCTCTGGAGGTTCAGTGTGGTGCAGGGCTGACCTTACTTTGGAGCCCCCCAGATC
ACATGTACCTGTACCAGCATGTCCTGGCCACTCTACAGTGCCGAGACCTACTAAGAGCCACTGTGTTTCCTGAGACTGTACCATCCCTTG
CACTAGAGACTTCAGGAACTACTTCTGAGCTAGAAGGCCGTGCCCCTGAGCCATTACCCCCAAAGCGGCTGCTAAACCTAACCCTGGAGG
TGAGCACAGCCAAGCTCACAGCTTTTGTAGCTGAGGACAAGTTCATTACCCTGGCTGCAGAGAGTGTGTCACTGAGCCGGCATGGAGGTT
CCCTGCAGGCATACTGTCCAGAGCTGGCTGCTGGCTTTGATGGCAATAGTATCTTCAACTTCAAGGAGGTGGAGGTGCAGCTGCTACCTG
AGCTGGAAGAGATGATCCTCCACCGGAACCCCTTCCCTGCGCTGCAGACCCTCCGGAACCGTGTTTGGCTCCTCTCTTTCGGCTCAGTCT
CGGTGGAGTTTCCTTATCAGTATGACTTTTCTCGAACTCTAGATGAGGCTGTGGGAGTTCAGAAGTGGCTGAAGGGACTACATCAAGGGA
CTCGTGCTTGGGCCTCTCCAAGCCCTGTCCCACTCCCACCTGATCTACTCTTAAAGGTTGAGCACTTCTCATGGGTTTTCTTGGATGATG
TTTTTGAGGTGAAACTTCATGATAACTACGAGCTGATGAAGGATGAAAGTAAGGAGAGTGCCAAAAGACTACAGCTACTGGATGCTAAAG
TGGCCGCCCTTCGGAAGCAGCATGGGGAGTTGTTGCCTGCCCGCAAAATTGAGGAGCTCTATGCCTCTTTGGAACGCAAAAACATTGAAA
TCTACATCCAGCGTTCCCGTCGTCTCTATGGCAACACACCCATGCGCCGGGCACTGCTTACTTGGAGCTTAGCAGGGCTAGAACTGGTAG
CTCTGGCAGATGCCTCCTTCCATGGTCCTGAGCATGTGGTAGAACAGGTTCAAGAGCTTGATCCAGGCAGCCCTTTTCCCCCTGAGGGAT
TAGATCTTGTCATTCAGTGGTGTCGAATGCTCAAGTGCAATGTCAAGAGCTTTCTGGTTCGGATCAGGGACTATCCACGGTACCTGTTTG
AGATCCGTGACTGGCGGCTAATGGGTCGACTTGTGGGCACCGAGCAGAGTGGTCAGCCTTGCTCCCGTCGGCGTCAGATCTTGCACTTGG
GGCTTCCGTGGGGTAACGTGGCAGTGGAGAGGAACATGCCCCCACTCAAATTCTACCATGACTTTCACTCGGAAATATTCCAGTACACAG
TGGTGTGGGGCCCATGCTGGGATCCAGCCTGGACACTAATTGGCCAGTGTGTGGACCTCTTGACCAAGCCCTCAGCTGACCCCAGCCCAC
CTTTGCCCTGGTGGGACAAGAGCCGTCTTCTGTTCCATGGAGACTGGCACATGGACATTGAACAGGCGAACCTGCACCAGCTGGCCACTG
AGGATCCATACAACACAACTGAAAATATGCACTGGGAGTGGAGCCACCTGTCTTTTCATTGGAAACCTGGTCAGTTTGTGTTCAAGGGTG
ACTTGGATATCAACGTGAGAACAGCCTCTAAGTATGACGACTGCTGCTTCCTTCACCTGCCTGACCTCTGCATGACACTGGACCTGCAGT
GGCTGTGCCATGGGAACCCCCATGATCACCATAGTGTCACTCTGCGGGCCCCAGAGTTCCTGCCTGAGGTGCCCTTGGGCCAGCTTCATG
ACTCCTACCGGGCCTTTCGCTCGGAGAACCTCAATCTCTCCATCAAGATGGATCTGACTCGGCACAGTGGAACAATATCCCAGCCCCGAA
TTCTGCTATATAGTAGTACCCTGCGCTGGATGCAAAACTTCTGGGCAACTTGGACAAGTGTCACAAGGCCTATCTGCAGGGGAAAGCTCT
TCAATAACCTGAAACCCAGCAAGAAGAAACTTGGTCAGCACTACAAGCAACTTTCCTATACAGCCCTCTTTCCCCAGCTGCAGGTACATT
ATTGGGCCTCATTTGCCCAGCAACGGGGCATCCAGATTGAGTGCAGTCAGGGCCATGTCTTCACTCGGGGGACTCAGCGGCTTATACCTC
AAGCAGGCACAGTGATGCGGCGCCTTATCTCTGATTGGAGTGTTACCCAGATGGTGAGTGACCTAAGTCAGGTGACCGTTCACCTGATGG
CCTCACCCACTGAAGAGAATGCTGATCACTGTCTTGATCCCTTGGTAACAAAGACCCACCTGCTGAGCTTGTCCTCCCTCACCTACCAAC
GGCATAGCAATCGCACAGCTGAGGAGGAGCTCTCTGCTCGTGATGGGGATCCTACCTTTCATACACATCAGCTGCACTTAGTAGATTTAC
GGATTTCCTGGACAACTACCAATCGAGACATTGCCTTTGGGTTATATGATGGGTACAAAAAGGCAGCTGTACTCAAACGTAATCTTTCTA
CTGAGGCCCTGAAGGGGTTAAAGATTGATCCACAGATGCCAGCCAAAAAGCCAAAGCGGGGTGTCCCAACTAGTGCCTCAGCCCCACCTC
GTGTTAACACTCCCAGCTTCAGTGGACAACCTGATAAGGGGTCATCAGGAGGTGCTTACATGTTGCAGAAGCTAATTGAAGAGACAGATA
GGTTTGTAGTGTTCACAGAAGAGGAATCAGGCATGAGTGACCAGTTGTGTGGCATTGCTGCCTGCCAGACGGATGACATATACAACCGAA
ACTGCCTTATTGAATTGGTCAACTGTCAGATGGTTCTTCGTGGAGCAGAGACAGAAGGCTGTGTCATTGTGTCAGCTGCCAAAGCCCAAC
TGCTGCAGTGCCAGCACCATCCAGCCTGGTATGGTGATACATTGAAGCAAAAGACATCCTGGACTTGCCTCTTGGATGGCATGCAGTACT
TTGCCACCACTGAAAGCAGCCCCACAGAGCAGGATGGCCGACAGCTCTGGTTAGAGGTGAAGAATATCGAGGAGCACCGGCAGCGTAGTC
TGGACTCTGTGCAGGAGCTGATGGAGAGTGGGCAGGCAGTGGGCGGCATGGTTACCACAACCACAGATTGGAACCAGCCAGCTGAGGCAC
AGCAAGCCCAGCAAGTCCAGCGGATCATTTCGCGTTGCAACTGCCGAATGTACTATATTAGTTACAGCCATGACATTGATCCTGAACTAG
CAACTCAGATTAAGCCACCTGAAGTTCTTGAGAACCAGGAAAAGGAAGATCTCCTAAAGAAGCAGGAAGGGGCTGTGGATACCTTCACCC
TTATCCACCATGAGCTGGAAATTTCCACCAACCCAGCTCAGTATGCCATGATCCTGGACATTGTCAACAACCTGCTGCTCCATGTAGAAC
CTAAGCGGAAGGAACATAGTGAGAAGAAGCAACGGGTCAGGTTCCAGCTTGAGATCTCTAGCAATCCAGAGGAGCAACGCAGCAGCATAC
TGCATTTGCAGGAGGCTGTGCGGCAGCATGTGGCCCAAATACGACAGCTGGAGAAGCAGATGTATTCTATCATGAAGTCTTTGCAGGATG
ACAGCAAGAATGAGAATCTGCTTGACCTGAACCAGAAGCTTCAGTTGCAGCTAAACCAGGAGAAGGCCAACCTGCAGCTGGAAAGTGAAG
AACTGAATATCCTCATCAGGTGTTTTAAGGATTTCCAACTGCAGCGGGCTAACAAGATGGAGCTGCGAAAGCAGCAAGAAGATGTGAGTG
TGGTCCGTCGCACTGAGTTTTACTTTGCTCAGGCACGGTGGCGCCTGACAGAGGAAGATGGACAGCTGGGAATTGCTGAATTAGAACTGC
AGAGGTTCCTCTACAGCAAGGTGAATAAGTCTGATGACACAGCAGAACATCTTCTGGAGTTGGGCTGGTTTACCATGAACAACCTCCTCC
CCAATGCTGTCTATAAGGTAGTACTGCGGCCCCAGAGCTCCTGCCAGTCTGGGCGACAGCTAGCTCTCCGCCTCTTCAGCAAAGTTCGGC
CCCCTGTTGGGGGTATCTCTGTTAAGGAGCATTTTGAGGTAAATGTGGTGCCTCTCACCATCCAGCTGACACACCAGTTCTTCCACAGAA
TGATGGGCTTTTTCTTTCCTGGCCGAAGTGTGGAAGATGATGAAGTTGGTGATGAAGAGGATAAGTCCAAACTGGTGACTACTGGAATAC
CAGTGGTGAAGCCTCGGCAGCTGATTGCAACAGATGATGCAGTACCACTGGGCCCTGGGAAGGGTGTGGCACAGGGTTTGACTCGGAGTT
CTGGGGTCAGAAGGTCATTTCGCAAATCGCCAGAGCACCCTGTGGATGACATTGACAAGATGAAAGAGCGAGCTGCCATGAACAACTCCT
TCATCTACATAAAGATTCCACAGGTTCCACTGTGTGTCAGCTACAAGGGTGAGAAGAACAGTGTGGACTGGGGTGACCTTAACCTGGTGC
TGCCCTGTCTGGAGTACCACAACAACACATGGACATGGCTAGACTTTGCCATGGCTGTCAAAAGGGACAGCCGCAAAGCCCTGGTTGCCC
AGGTAATCAAAGAGAAGCTAAGGCTGAAGTCTGCAACAGGCTCTGAGGTCCGGGGAAAGCTAGAAACTAAATCGGACCTGAACATGCAAC
AGCAGGAAGAGGAGGAGAAAGCCCGGCTCCTCATTGGTTTAAGTGTGGGCGACAAGAACCCTGGCAAGAAGTCCATCTTTGGCAGGCGCA
AATGATTTGGCGATTCGAGTGGCTGCAGTACAGGATCTGACTCTGGCTCAGGCTCCAGGGACTTGTGGGGTGGGAGGGGCTTCCCGTTAT
CCACGAGGATTTGTGGGTGTCAGAGCCCATAGGCATCACTCTTCAGCACCTGGTCTGTTCGCTGCAGGGCATGGTGGACAGTAATGCTGA

>28508_28508_3_FAM134C-KIAA0100_FAM134C_chr17_40761104_ENST00000309428_KIAA0100_chr17_26965112_ENST00000544884_length(amino acids)=1732AA_BP=1
MGSYNQPLGLSSTQSDTLFLDCTIRGLQVEASDTCAQCLSRILSLMGPQSGKSAVSRHSSFGESVSLLWKVDLKVEDMNLFTLSALVGAS
EVRLDTLTILGSAETSTVGIQGLVLALVKSVTEKMQPCCKAPDIPTPVLSLSMLSITYHSSIRSLEVQCGAGLTLLWSPPDHMYLYQHVL
ATLQCRDLLRATVFPETVPSLALETSGTTSELEGRAPEPLPPKRLLNLTLEVSTAKLTAFVAEDKFITLAAESVSLSRHGGSLQAYCPEL
AAGFDGNSIFNFKEVEVQLLPELEEMILHRNPFPALQTLRNRVWLLSFGSVSVEFPYQYDFSRTLDEAVGVQKWLKGLHQGTRAWASPSP
VPLPPDLLLKVEHFSWVFLDDVFEVKLHDNYELMKDESKESAKRLQLLDAKVAALRKQHGELLPARKIEELYASLERKNIEIYIQRSRRL
YGNTPMRRALLTWSLAGLELVALADASFHGPEHVVEQVQELDPGSPFPPEGLDLVIQWCRMLKCNVKSFLVRIRDYPRYLFEIRDWRLMG
RLVGTEQSGQPCSRRRQILHLGLPWGNVAVERNMPPLKFYHDFHSEIFQYTVVWGPCWDPAWTLIGQCVDLLTKPSADPSPPLPWWDKSR
LLFHGDWHMDIEQANLHQLATEDPYNTTENMHWEWSHLSFHWKPGQFVFKGDLDINVRTASKYDDCCFLHLPDLCMTLDLQWLCHGNPHD
HHSVTLRAPEFLPEVPLGQLHDSYRAFRSENLNLSIKMDLTRHSGTISQPRILLYSSTLRWMQNFWATWTSVTRPICRGKLFNNLKPSKK
KLGQHYKQLSYTALFPQLQVHYWASFAQQRGIQIECSQGHVFTRGTQRLIPQAGTVMRRLISDWSVTQMVSDLSQVTVHLMASPTEENAD
HCLDPLVTKTHLLSLSSLTYQRHSNRTAEEELSARDGDPTFHTHQLHLVDLRISWTTTNRDIAFGLYDGYKKAAVLKRNLSTEALKGLKI
DPQMPAKKPKRGVPTSASAPPRVNTPSFSGQPDKGSSGGAYMLQKLIEETDRFVVFTEEESGMSDQLCGIAACQTDDIYNRNCLIELVNC
QMVLRGAETEGCVIVSAAKAQLLQCQHHPAWYGDTLKQKTSWTCLLDGMQYFATTESSPTEQDGRQLWLEVKNIEEHRQRSLDSVQELME
SGQAVGGMVTTTTDWNQPAEAQQAQQVQRIISRCNCRMYYISYSHDIDPELATQIKPPEVLENQEKEDLLKKQEGAVDTFTLIHHELEIS
TNPAQYAMILDIVNNLLLHVEPKRKEHSEKKQRVRFQLEISSNPEEQRSSILHLQEAVRQHVAQIRQLEKQMYSIMKSLQDDSKNENLLD
LNQKLQLQLNQEKANLQLESEELNILIRCFKDFQLQRANKMELRKQQEDVSVVRRTEFYFAQARWRLTEEDGQLGIAELELQRFLYSKVN
KSDDTAEHLLELGWFTMNNLLPNAVYKVVLRPQSSCQSGRQLALRLFSKVRPPVGGISVKEHFEVNVVPLTIQLTHQFFHRMMGFFFPGR
SVEDDEVGDEEDKSKLVTTGIPVVKPRQLIATDDAVPLGPGKGVAQGLTRSSGVRRSFRKSPEHPVDDIDKMKERAAMNNSFIYIKIPQV
PLCVSYKGEKNSVDWGDLNLVLPCLEYHNNTWTWLDFAMAVKRDSRKALVAQVIKEKLRLKSATGSEVRGKLETKSDLNMQQQEEEEKAR

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for FAM134C-KIAA0100

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for FAM134C-KIAA0100

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for FAM134C-KIAA0100

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source