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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:AGBL5-CHD5 (FusionGDB2 ID:2856) |
Fusion Gene Summary for AGBL5-CHD5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: AGBL5-CHD5 | Fusion gene ID: 2856 | Hgene | Tgene | Gene symbol | AGBL5 | CHD5 | Gene ID | 60509 | 84181 |
| Gene name | ATP/GTP binding protein like 5 | chromodomain helicase DNA binding protein 6 | |
| Synonyms | CCP5|RP75 | CHD-6|CHD5|RIGB | |
| Cytomap | 2p23.3 | 20q12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cytosolic carboxypeptidase-like protein 5cytosolic carboxypeptidase 5 | chromodomain-helicase-DNA-binding protein 6ATP-dependent helicase CHD6helicase C-terminal domain- and SNF2 N-terminal domain-containing proteinradiation-induced gene B protein | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | Q8NDL9 | Q8TDI0 | |
| Ensembl transtripts involved in fusion gene | ENST00000323064, ENST00000360131, | ENST00000378021, ENST00000262450, | |
| Fusion gene scores | * DoF score | 5 X 9 X 2=90 | 2 X 2 X 2=8 |
| # samples | 9 | 2 | |
| ** MAII score | log2(9/90*10)=0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: AGBL5 [Title/Abstract] AND CHD5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | AGBL5(27276821)-CHD5(6214829), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene breakpoints across AGBL5 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across CHD5 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS5.0 | N/A | BF363390 | AGBL5 | chr2 | 27276821 | - | CHD5 | chr1 | 6214829 | - |
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Fusion Gene ORF analysis for AGBL5-CHD5 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000323064 | ENST00000378021 | AGBL5 | chr2 | 27276821 | - | CHD5 | chr1 | 6214829 | - |
| 5CDS-5UTR | ENST00000360131 | ENST00000378021 | AGBL5 | chr2 | 27276821 | - | CHD5 | chr1 | 6214829 | - |
| In-frame | ENST00000323064 | ENST00000262450 | AGBL5 | chr2 | 27276821 | - | CHD5 | chr1 | 6214829 | - |
| In-frame | ENST00000360131 | ENST00000262450 | AGBL5 | chr2 | 27276821 | - | CHD5 | chr1 | 6214829 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000323064 | AGBL5 | chr2 | 27276821 | - | ENST00000262450 | CHD5 | chr1 | 6214829 | - | 9566 | 655 | 1162 | 2364 | 400 |
| ENST00000360131 | AGBL5 | chr2 | 27276821 | - | ENST00000262450 | CHD5 | chr1 | 6214829 | - | 9563 | 652 | 1159 | 2361 | 400 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000323064 | ENST00000262450 | AGBL5 | chr2 | 27276821 | - | CHD5 | chr1 | 6214829 | - | 0.31786445 | 0.6821355 |
| ENST00000360131 | ENST00000262450 | AGBL5 | chr2 | 27276821 | - | CHD5 | chr1 | 6214829 | - | 0.31822208 | 0.68177795 |
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Fusion Genomic Features for AGBL5-CHD5 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for AGBL5-CHD5 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:27276821/chr1:6214829) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| AGBL5 | CHD5 |
| FUNCTION: Metallocarboxypeptidase that mediates protein deglutamylation. Specifically catalyzes the deglutamylation of the branching point glutamate side chains generated by post-translational glutamylation in proteins such as tubulins. In contrast, it is not able to act as a long-chain deglutamylase that shortens long polyglutamate chains, a process catalyzed by AGTPBP1/CCP1, AGBL2/CCP2, AGBL3/CCP3, AGBL1/CCP4 and AGBL4/CCP6. Mediates deglutamylation of CGAS, regulating the antiviral activity of CGAS. {ECO:0000250|UniProtKB:Q09M02}. | FUNCTION: Chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. May specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3. Plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. Tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. Downstream activated genes may include CDKN2A that positively regulates the p53/TP53 pathway, which in turn, prevents cell proliferation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. {ECO:0000269|PubMed:23948251}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | CHD5 | chr2:27276821 | chr1:6214829 | ENST00000262450 | 0 | 42 | 49_116 | 0 | 3082.3333333333335 | Compositional bias | Note=Lys-rich | |
| Tgene | CHD5 | chr2:27276821 | chr1:6214829 | ENST00000262450 | 0 | 42 | 1028_1193 | 0 | 3082.3333333333335 | Domain | Helicase C-terminal | |
| Tgene | CHD5 | chr2:27276821 | chr1:6214829 | ENST00000262450 | 0 | 42 | 497_554 | 0 | 3082.3333333333335 | Domain | Chromo 1 | |
| Tgene | CHD5 | chr2:27276821 | chr1:6214829 | ENST00000262450 | 0 | 42 | 592_653 | 0 | 3082.3333333333335 | Domain | Chromo 2 | |
| Tgene | CHD5 | chr2:27276821 | chr1:6214829 | ENST00000262450 | 0 | 42 | 712_896 | 0 | 3082.3333333333335 | Domain | Helicase ATP-binding | |
| Tgene | CHD5 | chr2:27276821 | chr1:6214829 | ENST00000262450 | 0 | 42 | 847_850 | 0 | 3082.3333333333335 | Motif | Note=DEAH box | |
| Tgene | CHD5 | chr2:27276821 | chr1:6214829 | ENST00000262450 | 0 | 42 | 725_732 | 0 | 3082.3333333333335 | Nucleotide binding | ATP | |
| Tgene | CHD5 | chr2:27276821 | chr1:6214829 | ENST00000262450 | 0 | 42 | 343_653 | 0 | 3082.3333333333335 | Region | Note=Histone-binding | |
| Tgene | CHD5 | chr2:27276821 | chr1:6214829 | ENST00000262450 | 0 | 42 | 343_390 | 0 | 3082.3333333333335 | Zinc finger | PHD-type 1 | |
| Tgene | CHD5 | chr2:27276821 | chr1:6214829 | ENST00000262450 | 0 | 42 | 416_463 | 0 | 3082.3333333333335 | Zinc finger | PHD-type 2 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | AGBL5 | chr2:27276821 | chr1:6214829 | ENST00000323064 | - | 1 | 11 | 540_544 | 0 | 718.0 | Compositional bias | Note=Poly-Pro |
| Hgene | AGBL5 | chr2:27276821 | chr1:6214829 | ENST00000323064 | - | 1 | 11 | 651_654 | 0 | 718.0 | Compositional bias | Note=Poly-Ser |
| Hgene | AGBL5 | chr2:27276821 | chr1:6214829 | ENST00000360131 | - | 1 | 15 | 540_544 | 0 | 887.0 | Compositional bias | Note=Poly-Pro |
| Hgene | AGBL5 | chr2:27276821 | chr1:6214829 | ENST00000360131 | - | 1 | 15 | 651_654 | 0 | 887.0 | Compositional bias | Note=Poly-Ser |
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Fusion Gene Sequence for AGBL5-CHD5 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >2856_2856_1_AGBL5-CHD5_AGBL5_chr2_27276821_ENST00000323064_CHD5_chr1_6214829_ENST00000262450_length(transcript)=9566nt_BP=655nt CCCGGCACCGCGGCGCTCGGGTGTTTTTGGGGGCCCGGGTGGAGGGCCCGGGTGCCGGGGCCCAAGGTGCGGCCTCGCTAGCGGGAGAGG GAGCGGGATCACCGGCCCGGAGAGAGCTCTCAGGGCCAGAGCGGGGCAGGAGGATGCTTTCCCAGCCCCACCATGGAGCTGCGCTGTGGG GGATTGCTGTTCAGTTCTCGCTTTGATTCAGGGAATCTAGCCCACGTGGAGAAGGTGGAATCTTTGTCCAGTGATGGGGAAGGGGTAGGA GGTGGGGCGTCAGCCCTGACCAGTGGCATTGCCTCTTCCCCTGACTATGAATTCAACGTGTGGACCCGACCAGACTGTGCTGAAACGGAA TTTGAGAATGGGAACAGGTCATGGTTCTACTTCAGCGTCCGGGGAGGAATGCCAGGAAAACTCATCAAGATCAACATTATGAACATGAAC AAGCAGAGCAAGCTGTATTCCCAGGGCATGGCCCCCTTTGTGCGCACACTGCCCACCCGGCCACGCTGGGAACGCATTCGAGACCGGCCC ACCTTTGAGCCACCACCTTCTTCGCCTTCTGCTACCCCTTCTCCTACAGTGACTGCCAGGAACTGCTAAACCAGCTAGACCAGCGCTTTC CGGAGAACCACCCTACCCATAGCAGCCACGCCTGCCGGGCCACCTGCCCGACCCACATGGGAGAGAAAAGCTGCCACCTTTTTAGGAGCC AGCGCCACCTTGGGACAAAAAGGGAAACCTAGTAATGCCATCACATGGAGGACGAGGCCCAGCTCAGCTGGGCCAGAGCCCAGAAGTGCC ACCTCATCATAATTCAAGTGTTCTTCCACACAGCGTTGCCCCCACAACCACGCCGGACGTGCCCCCTCGCCACCTTTTCCAGACGACTTC TTAGAAGAGATTTCATTTATTTGTACATCTTTTGCACTTTCCTATTGAAGACTTGAACACGTTTGTCTTGATAAAAGTTGGATGACGTAT GGAAGATTCGAACCTGCAGCACTGATGTCTCTTTACCGATGGGTTCCAGACCCAAGGTAGTCCTGGCACTGCCCTGTGGACTCAGCCCAG CTGGGGAGGACATGGCGCCCGGTGCCCTAGGAGCCCTCAGTGTCCCCTACCTGACCTGTCTGCACCTGTGTGACAGCCCCTTCTGATTTG GCCCCCTGCCCGCTTGGAGCCTCCCAGCACCAGACAGGGCAGGTTTGGGGAGCCGCTGTCCAGCCCTATGGTGAGACCCTGGCTGACATT TCCCCTCCTTCCTGCCAAGGCTGGAGGCCGCCAGGTGTTTGCTCTCTCCTTGTGGGGAGGTGGATCCTCTGCCAGCAGGTGTCTGTCCCC GGCCCAGCGCATCTTGAAGGCCCTGGACTCTGTTACCAGTGGGGGGCCTGTGGCCCCGGCTCTTCACAGCAGGCAGAAGCGTATGATCCC AGGGAGGGTGGGCTGGGGGGGGGGCAGCACTTGCCTCGGAGCCACTGCTGCGTTGGGTTTGCCTTCTGCCAGAGGTGTGGTTAAGGGCAG TGATAGCTGCGCCCCAGCAAGGAGGGTCATGGGCCCTGAGCTGGCCCAGGAGACCCTGGCCCTGCCCTGTGCCCTGGGATGCCTACCCTG CCCACCTCCGGAGGTGGAACCGGGCTGCCCCTGGGGGCCTGGACTTGTCCCATTCCCCTGTCCCTGGAAAGGCCTTCCCGGGGGCTTTTT GCCTGAGGCTGCACTCTTGGAAGGCGTGGGGAGAGTTCTGCCTGGAGGGGGACTGGACCCAGTGCCCTCTGCAGACCCCTCCCAGCCGCA GCACCAAGGGCTTGCTGCCTTGTTTCCTGCCAGGAGCGCCCTGACATCCCAAAACCATCTTCCCACATGTGGGTTGTTGGAATCCCACCC ACTCCCCCGGACCCTGCCCCTCCAAGTTGGGGACGGAGATGGGGAGCAGGTCAGGCCCTCCCTAGGCCTGTTTGTGTGTGATCCTTCTCC TGGCCCCAGGTCGACCTGGAAGGCGTTTCTGAGTCTTGTACTGGGACCTTCCCAGGGAAGGTGCCTTGGGGTGCAGAATCCTGGGAATGT TAGGAAAGGGCTGCGTGAAAAACCCAGCTGGGCCTGGGGTGGAGGTGCACACGGGCTGGGGCTCAGCTCCTTGGAGAGGGCCTGCCTGGG ACTGAGGGGGCCAGGGCTGGGTCAGGATTCACCAGCTTGTGTTGCAGACACTGGAGCGATTGCCTGGCCCTCCCTAAGCCCTATATGCCT CACTCATAATGAGGCTGTCTCTGAACCCCGGAGGGCGGGACCTACAAGTCCTTCCTCTTGGCGCATTCCCACACTCCAGTCTGGATCCAG GTCTGCAAGGCCAGCCCGACCCTGACACTGCACGTGGGCGTAGTGGGGAGCACCCTGGAGTGGAGATGATTGTCAGCGGGCTCACATGTT ATGGTTCATCCACATGCGTGTTGTGTGCTCTGCGGTGCCTCCTGGCAAAGGGTCCTGGCTCGGGTCAGAAGCTCACTCCCGTGCCCTCGT CCCCAAACAAGCAGTGGCAAGCACTGGGGTTGGCCCTCGTTGGGAGCAGTGCCCACCTTCCTTGGCCCACAGCAGATAGGTCCCGAGCAG CAGGACTGGAGGCCTGTGGCGGTCAGGGCAGGGGTCTGTGTCTCCACCCCAAGGGCTGATGGTCCCTCCCCTGTGCGCCTTCCTCTCAGG CAGGCTTGCTCTGTCCCTTCCTCTCTGCTTCCCTCCCAGGCCTCGCCAGGGCTCCCTTCTCCTCTGCCTGGTTAGACTCGGGCACCCAGG AAAGCCTGGCCAGGGCTCCTTTGGGCCTGGGCCCCCTGCACTGCCTGGTCCAGAAGGGGTGGTGCTGTCCGTGGCCAGCACCCCGGGGCC CGGGAGGGGTGGGCTACTAGAGTCAGAGCGGGTTTGGGGCTGACCAGTTTGGGAGAGGAGAAAAGATCTGAGAATGTCCTTCTTGGTTTG TCAGTCATCTCTGCCAAAAGTGGTGATGGTGGTGTCCGTATGTTTGGCGTCTTTGGGCTGGGTTTGGTTTTTGCTGCTGGTAGAATCAGG GTCCTCGGGCATGAACGCGAGCCCAAAGTGCCAGTCTGCGATTGGAAATTTCCAGCCACTTTAAGCCAGTGCTGAGTAGGGCTTCTGCAG AGCCATGTTTGAGCCAAGGTCTTGGAAGGCATTGCCCCATGGGCTCAGGTGACTCGGGGTGGAGTGAGCACGTCTGCAGGGCCCTCTCAT ACACGCCTGAGGCAGAAGCAGCGTCCCCCGTGAAAGCCACCTTCCGAAGCTCCTGCGTTTTTTGCAAACTTGGCTTCCCCCAGGGGCAGG CTGGACTTTCCCTGCCCCCTATGATTGAAGTCCTCCTGCTTTTGGGGGCTGCCTTCCCAGAGTCCCCCGGGTGCTCCCCTGCCGAGGTCA GGAGCTGACCAAGCCTTGGCCCGGTGACACCTGCAGCCCTCACTCCTGTCATCCCAGGACACTTGAGGCCCAAGGAGGTGGAGTGGAGAG TGGGCTCGGGTACATGGGAGCCAGAAGCCAGATGGACTTGGTCAAGTGTCGGTCACTTGGAGCCTCCAGTGTGCGTCAGGGTCTGTGGGC AGGGGACAGGGCGTGGGTGGGGGCCGAGGCTGGCACGCCCCTCTGCCCTCACCGTCTTGGTGACCTGGCCTCGGCCCCTCCCCCAAGTCT CTTCTGTGCAAGGCCCGCCTCGGCCTCGGCAGCTGGTTCCTGTCCTGTTTTCTGTGTCTGAAAGTTTACAGGTTGTGGTGCATCAGCCCA AACTCACTGGCGTTGTGTTTTTTTTTTCTTTAATTTTCAGATTTTTTTTTTAAACAAAGTATTTTTTTAGGTGCGATAACCCAGAAAGGG CCCGTTGGGTGTGTGTGTGTGTCCTGAACTCCTCAAGCAGCGATTGGAGCCCAAGCACCCCTGGAGAGGAAGGGAGGGTCCCCACTGGCC CGTGGGGTCTGAGTTCAGGGGTGTGGAGGGAGCAGACTCCACCGGCCCAGGCCCAGCTAAGAGGGGGCCGACCCCTTTCCCCAGGCACAG CCCCAGGCTGGCAAAGGGAGGGCCCTGGGCTGGGTGCAAGGCGCGCCAGGAGTCCCAGCCAGGGTGGCCCCGGCGGGGGCGGGTCCAGCT TTGGAAGCCAGGCTCCCCTGTGAGCCGTGGCTTGTCTGGTCTTCGCCCACGGGAGGCTGGACAGAGGCTGTAGCCAACACAATCACCTTT ACTTTGTACTCTGTGTGTATGTTTTGGTTTTCTGTGTTTTAATAAATCCTTTGGGAAAGGATATCTAGCCGTCCTCGAGACTTCCCTGTG TTGCAGCGCTCATTTCCAGCTGAGGGCGCTTTCGGCTCCTCCCAGATGTACAGCAACAACTTTGGGCCCAACTTCCGGGGCCCTGGACCG GGAGGGATTGTCAACTACAACCAGATGCCCCTGGGGCCCTATGTGACCGTCCTGAACCAGCTGGAGGAGCTGCTGAGCGACATGAAGGCC GACGTGACCCGGCTGCCATCCATGCTGTCCCGCATCCCCCCGGTGGCCGCCCGGCTGCAGATGTCGGAGCGCAGCATCCTGAGCCGCCTG ACCAACCGCGCCGGGGACCCCACCATCCAGCAGCTGCTGGAGCAGGCGTTGGTCATTGAGGAGCAGCTCCGGAGGGCCGCGTACCTGAAC ATGACGCAGGACCCCAACCACCCCGCCATGGCCCTCAACGCCCGCCTGGCTGAAGTGGAGTGCCTCGCCGAGAGCCACCAGCACCTGTCC AAGGAGTCCCTTGCTGGGAACAAGCCTGCCAATGCCGTCCTGCACAAGGGCACGGCTACGCCCGCTGGCAGGACATCCAGAATGACCCAC GGTACATGATCCTCAACGAGCCCTTCAAGTCTGAGGTCCACAAGGGCAACTACCTGGAGATGAAGAACAAGTTCCTGGCCCGCAGGTTTA AGAGTTGCACACGCTGTGGCAGAACGAGGAGCGGGCTGCTGTATCCTCTGGGAAAATCTACGACATCTGGCACCGGCGCCATGACTACTG GCTGCTGGCGGGCATCGTGACATGACACCAAGGCTGAGGAGAAGGAGCCCATTGAAACACAGCAAAATGGTGACAAAGAGGAAGATGACG AGGGGAAGAAGGAGGACAAGAAGGGGAAATTCAAGTTCATGTTCAACATCGCGGACGGGGGCTTCACGGAGGAGGTGCTTCCTGAGAAGG AGAAGATCCTGGACAAGCTGGAGCTGAGCTTGATCCACAGCAGAGGGGACAGTTCCGAACTCAGGCCAGGCCCTTCCAGCCGCCTTGGAT AGAGTGGAGAGTGAGGACAAGCACGAGAGCCCAGCCAGCAAGGAGAGAGCCCGAGAGGAGCGGCCAGAGGAGACGGAGAAGGCCCCGCCC TCCCCGGAGCAGCTGCCGAGAGACAAAATGGAAGCCCAGCTGGGCTACATGGATGAGAAAGACCCCGGGGCACAGAAGCCAAGGCAGCCC CTGGAAGTCCAGGTTCAGGAGTTTGAGCATGTCAACGGGAAGTACAGCACCCCAGACTTGATCCCTGAGGGGCCCGAGGGGAAGAAGTCG GGCGAGGTGATCTCCTCGGACCCCAACACACCAGTGCCCGCCAGCCCTGCCCACCTCCTGCCAGCCCCGCTGGGCCTGCCAGAGCCTATG TGTCCCTCTTCATGCGGCACCTGTGTGAGCCGGGGGCGGATGGTGCAGAGACCTTCGCAGACGGCGTGCCCCGGGAGGGCCTCTCCAGGC AGCACGTGCTGACCCGCATCGGGGTCATGTCACTAGTTAGGAAGAAGGTGCTGGGCTTCAATGCCCGACAGCGGAAGGCCTTTCTGAACG CCATCATGCGCTGGGGCATGCCCCCGCAGGACGCCTTCAACTCCCACTGGCTGGTGCGGGACCTTCGAGGGAAGAGCGAGAAGGAGTTTA GGTGGACGACGACAATCCCGGAGGCAGCTGAAGAGTGACAGGGACAAGCCCCTGCCCCCGCTTCTCGCCCGAGTTGGTGGCAACATCGAG AGTGGCAGGATGAGCTCTCTGATAACCAGTCAGAATATTCCATTGGCTCTGAGGATGAGGATGAGGACTTTGAAGAGAGGCCGGAAGGGC AGAGAGGAGGTGGAGCGGGAAATCATCAAGCAGGAGGAGAACGTGGACCCCGACTACTGGGAGAAGCTGCTGCGGCACCACTATGAGCAG CAGCAGGAGGACCTGGCCCGCAACCTGGGCAAGGGCAAGCGCATCCGCAAGCAGGTCAACTACAACGATGCCTCCCAGGAGGACCAGGGT GACAACAAGGACGTGGAGGACAGCAGTGTGATCCACTATGACGATGCGGCCATCTCCAAGCTGCTGGACCGGAACCAGGACGCTACAGAT GACACGGAGCTACAGAACATGAACGAGTACCTGAGCTCCTTCAAGGTGGCGCAGTACGTGGTGCGCGAGGAGGACGGCGTGGCATGATGT CTCAGGGCCAGAGGCCGGTCACACCCATCCCTGATGTCCAGTCCTCCAAAGGGGGGAACTTGGCCGCCAGTGCAAAGAAGAAGCACGGTA GCACCCCGCCAGGCCTTCAGCCGCGCCCACCGCATCGGCCAGAACAAGAAGGTGATGATCTACCGCTTCGTGACTCGGGCCTCGGTGGAG GAGCGCATCACGCAGGTGGCCAAGCGCAAGATGATGCTCACCCACCTGGTGGTGCGGCCCGGCCTCGGCTCCAAGTCGGGGTCCATGACC AAGCAGGAGCTGGACGACATCCTCAAGTTCGGCACGGAGGAACTCTTCAAGGACGACGTGGAGGCCCCCGGGGCCCAGCAGTTCTGCTTC CTCCTCTCAACCCGGGCAGGTGGTCTGGGCATCAACCTGGCCACGGCGGACACTGTCATCATCTACGACTCGGACTGGAACCCGCACAAT GACATCCAGATGACCAAGATGCTGGACCTCCTGGAGGACTTCCTGGAGTACGAAGGCTACAAGTATGAGCGGATTGATGGTGGCATCACC GGGGGCCTCCGGCAGGAGGCAATCGACAGATTCAATGGAGGCCCCTGTCTTGCCCAATGGCTCCTACGATGGAAGCTCCCTGGTCAAGTC TTCAGGGAAGCTCATGCTGCTACAGAAGATGCTGAAGAAACTGCGGGATGAGGGGCACCGTGTGCTCATCTTCTCCCAGGAAGTACTACA AGTTCATCCTCACACGGAACTTTGAGGCACTGAACTCCAAGGGGGGCGGGAACCAAGTATCGCTGCTCAACATCATGATGGACCTGAAAA AGTGCTGCAACCACCCCTACCTCTTCCCTGTGGCTGCCGTGCAACCTGGAGGGCTTCCTGGAGGAGTTTGCTGACATCTCCAAGGAAGAC CAGATCAAGAAGCTGCATGACCTGCTGGGGCCGCACATGCTCAGGCGGCTCAAGGCTGACGTGTTCAAGAACATGCCGGCCAAGACCGAG CTCATTGTCCGGGTGGAGCTGAGCCAGATGCAGAATTTTTTAGGGTCTTAAACAGCTACAAGATTGATTACAAGCTGCTGCTGACAGGGA CCCCCCTTCAGAACAACCTGGAGGAGCTGTTCCATCTCCTCAACTTCCTGACTCCAGAGAGGTTCAAAAAGAAGTGCAGATCAAATTCCA CGTGCTGCTCACCTCCTATGAGCTCATCACCATTGACCAGGCCATCCTGGGCTCCATCGAGTGGGCCTGCCTGGTGGTAGATGAGGCCCA CCGCCTCAAGAACAACCAGTCCAAGGGCCACTCCAAAGGGCCCTACCTGGTTAGCGCGCCCCTCTCCACCATCATCAACTGGGAACGCGA GTTTGAGATGTGGGCGCCCGACTTCTACGTGGTCACCTACACGGGGGACAAGGAGAGCCGCTCGGTGATTCGGGAGAACGAGTTTTCCTT TGAGGACAACGCCATTCGGAGTGGGAAGAAGGTATTCCGTATGAAGCCCACGGTCAAGTTCGACAAGCAGCCATGGTACATCGACTCCAC AGGCGGCACACTGCACCCGTACCAGCTGGAGGGCCTCAACTGGCTGCGCTTCTCTTGGGCCCAGGGCACTGACACCATCCTGGCCGATGA GATGGGTCTGGGCAAGACGGTGCAGACCATCGTGTTCCTTTACTCCCTCTACAAGGAGGGAGCTGATGCTGGGAGAAGACACCAGGCTGC CCAAGAGGCTGCTCAAGAAGGGCAAGAAGCTGAGGGACGACAAGCAGGAGAAGCCGCCGGACACGCCCATTGTGGACCTTTGACAAGAAG GGGGATGTGCACTACCTGATCAAGTGGAAAGACCTGCCCTACGACCAGTGCACCTGGGAGATCGATGACATCGACATCCCCTACTACGAC AACCTCAAGCAGGCCTACTGGGGCCACAGCTGGAGCTGTACCACACGGTGATGTATCGCAACTACCAAAGAAAGAACGACATGGATGAGC CGCCCCCCTTTGACTACGGCTCTGGGGATGAAGACGGCAAGAGCGAGAAGAGGAAGAACAAGGACCCCCTCTATGCCAAGATGGAGGAGC GCTTCTACCGCTATGGCATCAAGCCAGAGTGGATGATGATTCACCGAATCCTGAACCATAGTGCCCCCCACTGAAGGGCAAAGTCCAGCG GATTCTACACTGGAGGTGGACGGAGCCCCCTGCCCCCTTCATGGTGGGGCTGCCGGGGCCTGACGTGGAGCCCAGCCTCCCTCCACCTAA GCCCCTGGAGGGCATCCCTGAGAGAGAGTTCTTTGTCAAGTGGGCAGGGCTGTCCTACTGGCATTGCTCCTGGGTGAAGGAGCTACAGGA GAAGGAGGGGATCCAGTGGGAGCCGAAGGACGACGACGATGAAGAGGAGGAGGGCGGCTGCGAGGAGGAGGAGGACGACCACATGGAGTT CTGCCGCGTGTGCAAGGACGGGGGCGAGCTGCTCTGCTGCGACGCCTGCCCCTCCTCCTACCACCTGCATTGCCTCAACCCGCCGCTGCC CGAGATCCCAAACGGTGAATGGCTCTGCCCGCGCTGTACTTTGATGATGGTGACGGCTATGAGACAGACCACCAGGATTACTGTGAGGTG TGCCAGCAGGGTGGGGAGATCATCCTGTGCGACACCTGCCCGAGGGCCTACCATCTCGTATGCCTGGACCCAGAGCTGGAGAAGGCTCCC GAGGGCAAGTGGAGCTGCCCCCACTGTAGTGAAGAAGATGAGAGGGAGGAGTCGGACTTCGACAGCGCCAGCATCCACAGTGCCTCCGTG CGCTCCGAATGCTCTGCAGCCCTGGGCAAGAAGAGCAAGAGGAGGCGCAAGAAGAAGAGGAGGCCTGGAGTGAGGAAGAAGATCAAAGGC TCCAAAGATGGGAAGAAAAAGGGCAAAGGGAAAAAGACGGCCGGGCTCAAGTTCCGCTTCGGGGGGATCAGCAACAAGAGGAAGAAAGGC TCCTCGGGTGGCTGCGGCTGTAGAGACGGTCACCATCTCCCCTCCGCTAGCCGTCAGCCCCCCGCAGGTGCCCCAGCCTGTGCCTATCCG >2856_2856_1_AGBL5-CHD5_AGBL5_chr2_27276821_ENST00000323064_CHD5_chr1_6214829_ENST00000262450_length(amino acids)=400AA_BP= MIWPPARLEPPSTRQGRFGEPLSSPMVRPWLTFPLLPAKAGGRQVFALSLWGGGSSASRCLSPAQRILKALDSVTSGGPVAPALHSRQKR MIPGRVGWGGGSTCLGATAALGLPSARGVVKGSDSCAPARRVMGPELAQETLALPCALGCLPCPPPEVEPGCPWGPGLVPFPCPWKGLPG GFLPEAALLEGVGRVLPGGGLDPVPSADPSQPQHQGLAALFPARSALTSQNHLPTCGLLESHPLPRTLPLQVGDGDGEQVRPSLGLFVCD PSPGPRSTWKAFLSLVLGPSQGRCLGVQNPGNVRKGLREKPSWAWGGGAHGLGLSSLERACLGLRGPGLGQDSPACVADTGAIAWPSLSP -------------------------------------------------------------- >2856_2856_2_AGBL5-CHD5_AGBL5_chr2_27276821_ENST00000360131_CHD5_chr1_6214829_ENST00000262450_length(transcript)=9563nt_BP=652nt GGCACCGCGGCGCTCGGGTGTTTTTGGGGGCCCGGGTGGAGGGCCCGGGTGCCGGGGCCCAAGGTGCGGCCTCGCTAGCGGGAGAGGGAG CGGGATCACCGGCCCGGAGAGAGCTCTCAGGGCCAGAGCGGGGCAGGAGGATGCTTTCCCAGCCCCACCATGGAGCTGCGCTGTGGGGGA TTGCTGTTCAGTTCTCGCTTTGATTCAGGGAATCTAGCCCACGTGGAGAAGGTGGAATCTTTGTCCAGTGATGGGGAAGGGGTAGGAGGT GGGGCGTCAGCCCTGACCAGTGGCATTGCCTCTTCCCCTGACTATGAATTCAACGTGTGGACCCGACCAGACTGTGCTGAAACGGAATTT GAGAATGGGAACAGGTCATGGTTCTACTTCAGCGTCCGGGGAGGAATGCCAGGAAAACTCATCAAGATCAACATTATGAACATGAACAAG CAGAGCAAGCTGTATTCCCAGGGCATGGCCCCCTTTGTGCGCACACTGCCCACCCGGCCACGCTGGGAACGCATTCGAGACCGGCCCACC TTTGAGCCACCACCTTCTTCGCCTTCTGCTACCCCTTCTCCTACAGTGACTGCCAGGAACTGCTAAACCAGCTAGACCAGCGCTTTCCGG AGAACCACCCTACCCATAGCAGCCACGCCTGCCGGGCCACCTGCCCGACCCACATGGGAGAGAAAAGCTGCCACCTTTTTAGGAGCCAGC GCCACCTTGGGACAAAAAGGGAAACCTAGTAATGCCATCACATGGAGGACGAGGCCCAGCTCAGCTGGGCCAGAGCCCAGAAGTGCCACC TCATCATAATTCAAGTGTTCTTCCACACAGCGTTGCCCCCACAACCACGCCGGACGTGCCCCCTCGCCACCTTTTCCAGACGACTTCTTA GAAGAGATTTCATTTATTTGTACATCTTTTGCACTTTCCTATTGAAGACTTGAACACGTTTGTCTTGATAAAAGTTGGATGACGTATGGA AGATTCGAACCTGCAGCACTGATGTCTCTTTACCGATGGGTTCCAGACCCAAGGTAGTCCTGGCACTGCCCTGTGGACTCAGCCCAGCTG GGGAGGACATGGCGCCCGGTGCCCTAGGAGCCCTCAGTGTCCCCTACCTGACCTGTCTGCACCTGTGTGACAGCCCCTTCTGATTTGGCC CCCTGCCCGCTTGGAGCCTCCCAGCACCAGACAGGGCAGGTTTGGGGAGCCGCTGTCCAGCCCTATGGTGAGACCCTGGCTGACATTTCC CCTCCTTCCTGCCAAGGCTGGAGGCCGCCAGGTGTTTGCTCTCTCCTTGTGGGGAGGTGGATCCTCTGCCAGCAGGTGTCTGTCCCCGGC CCAGCGCATCTTGAAGGCCCTGGACTCTGTTACCAGTGGGGGGCCTGTGGCCCCGGCTCTTCACAGCAGGCAGAAGCGTATGATCCCAGG GAGGGTGGGCTGGGGGGGGGGCAGCACTTGCCTCGGAGCCACTGCTGCGTTGGGTTTGCCTTCTGCCAGAGGTGTGGTTAAGGGCAGTGA TAGCTGCGCCCCAGCAAGGAGGGTCATGGGCCCTGAGCTGGCCCAGGAGACCCTGGCCCTGCCCTGTGCCCTGGGATGCCTACCCTGCCC ACCTCCGGAGGTGGAACCGGGCTGCCCCTGGGGGCCTGGACTTGTCCCATTCCCCTGTCCCTGGAAAGGCCTTCCCGGGGGCTTTTTGCC TGAGGCTGCACTCTTGGAAGGCGTGGGGAGAGTTCTGCCTGGAGGGGGACTGGACCCAGTGCCCTCTGCAGACCCCTCCCAGCCGCAGCA CCAAGGGCTTGCTGCCTTGTTTCCTGCCAGGAGCGCCCTGACATCCCAAAACCATCTTCCCACATGTGGGTTGTTGGAATCCCACCCACT CCCCCGGACCCTGCCCCTCCAAGTTGGGGACGGAGATGGGGAGCAGGTCAGGCCCTCCCTAGGCCTGTTTGTGTGTGATCCTTCTCCTGG CCCCAGGTCGACCTGGAAGGCGTTTCTGAGTCTTGTACTGGGACCTTCCCAGGGAAGGTGCCTTGGGGTGCAGAATCCTGGGAATGTTAG GAAAGGGCTGCGTGAAAAACCCAGCTGGGCCTGGGGTGGAGGTGCACACGGGCTGGGGCTCAGCTCCTTGGAGAGGGCCTGCCTGGGACT GAGGGGGCCAGGGCTGGGTCAGGATTCACCAGCTTGTGTTGCAGACACTGGAGCGATTGCCTGGCCCTCCCTAAGCCCTATATGCCTCAC TCATAATGAGGCTGTCTCTGAACCCCGGAGGGCGGGACCTACAAGTCCTTCCTCTTGGCGCATTCCCACACTCCAGTCTGGATCCAGGTC TGCAAGGCCAGCCCGACCCTGACACTGCACGTGGGCGTAGTGGGGAGCACCCTGGAGTGGAGATGATTGTCAGCGGGCTCACATGTTATG GTTCATCCACATGCGTGTTGTGTGCTCTGCGGTGCCTCCTGGCAAAGGGTCCTGGCTCGGGTCAGAAGCTCACTCCCGTGCCCTCGTCCC CAAACAAGCAGTGGCAAGCACTGGGGTTGGCCCTCGTTGGGAGCAGTGCCCACCTTCCTTGGCCCACAGCAGATAGGTCCCGAGCAGCAG GACTGGAGGCCTGTGGCGGTCAGGGCAGGGGTCTGTGTCTCCACCCCAAGGGCTGATGGTCCCTCCCCTGTGCGCCTTCCTCTCAGGCAG GCTTGCTCTGTCCCTTCCTCTCTGCTTCCCTCCCAGGCCTCGCCAGGGCTCCCTTCTCCTCTGCCTGGTTAGACTCGGGCACCCAGGAAA GCCTGGCCAGGGCTCCTTTGGGCCTGGGCCCCCTGCACTGCCTGGTCCAGAAGGGGTGGTGCTGTCCGTGGCCAGCACCCCGGGGCCCGG GAGGGGTGGGCTACTAGAGTCAGAGCGGGTTTGGGGCTGACCAGTTTGGGAGAGGAGAAAAGATCTGAGAATGTCCTTCTTGGTTTGTCA GTCATCTCTGCCAAAAGTGGTGATGGTGGTGTCCGTATGTTTGGCGTCTTTGGGCTGGGTTTGGTTTTTGCTGCTGGTAGAATCAGGGTC CTCGGGCATGAACGCGAGCCCAAAGTGCCAGTCTGCGATTGGAAATTTCCAGCCACTTTAAGCCAGTGCTGAGTAGGGCTTCTGCAGAGC CATGTTTGAGCCAAGGTCTTGGAAGGCATTGCCCCATGGGCTCAGGTGACTCGGGGTGGAGTGAGCACGTCTGCAGGGCCCTCTCATACA CGCCTGAGGCAGAAGCAGCGTCCCCCGTGAAAGCCACCTTCCGAAGCTCCTGCGTTTTTTGCAAACTTGGCTTCCCCCAGGGGCAGGCTG GACTTTCCCTGCCCCCTATGATTGAAGTCCTCCTGCTTTTGGGGGCTGCCTTCCCAGAGTCCCCCGGGTGCTCCCCTGCCGAGGTCAGGA GCTGACCAAGCCTTGGCCCGGTGACACCTGCAGCCCTCACTCCTGTCATCCCAGGACACTTGAGGCCCAAGGAGGTGGAGTGGAGAGTGG GCTCGGGTACATGGGAGCCAGAAGCCAGATGGACTTGGTCAAGTGTCGGTCACTTGGAGCCTCCAGTGTGCGTCAGGGTCTGTGGGCAGG GGACAGGGCGTGGGTGGGGGCCGAGGCTGGCACGCCCCTCTGCCCTCACCGTCTTGGTGACCTGGCCTCGGCCCCTCCCCCAAGTCTCTT CTGTGCAAGGCCCGCCTCGGCCTCGGCAGCTGGTTCCTGTCCTGTTTTCTGTGTCTGAAAGTTTACAGGTTGTGGTGCATCAGCCCAAAC TCACTGGCGTTGTGTTTTTTTTTTCTTTAATTTTCAGATTTTTTTTTTAAACAAAGTATTTTTTTAGGTGCGATAACCCAGAAAGGGCCC GTTGGGTGTGTGTGTGTGTCCTGAACTCCTCAAGCAGCGATTGGAGCCCAAGCACCCCTGGAGAGGAAGGGAGGGTCCCCACTGGCCCGT GGGGTCTGAGTTCAGGGGTGTGGAGGGAGCAGACTCCACCGGCCCAGGCCCAGCTAAGAGGGGGCCGACCCCTTTCCCCAGGCACAGCCC CAGGCTGGCAAAGGGAGGGCCCTGGGCTGGGTGCAAGGCGCGCCAGGAGTCCCAGCCAGGGTGGCCCCGGCGGGGGCGGGTCCAGCTTTG GAAGCCAGGCTCCCCTGTGAGCCGTGGCTTGTCTGGTCTTCGCCCACGGGAGGCTGGACAGAGGCTGTAGCCAACACAATCACCTTTACT TTGTACTCTGTGTGTATGTTTTGGTTTTCTGTGTTTTAATAAATCCTTTGGGAAAGGATATCTAGCCGTCCTCGAGACTTCCCTGTGTTG CAGCGCTCATTTCCAGCTGAGGGCGCTTTCGGCTCCTCCCAGATGTACAGCAACAACTTTGGGCCCAACTTCCGGGGCCCTGGACCGGGA GGGATTGTCAACTACAACCAGATGCCCCTGGGGCCCTATGTGACCGTCCTGAACCAGCTGGAGGAGCTGCTGAGCGACATGAAGGCCGAC GTGACCCGGCTGCCATCCATGCTGTCCCGCATCCCCCCGGTGGCCGCCCGGCTGCAGATGTCGGAGCGCAGCATCCTGAGCCGCCTGACC AACCGCGCCGGGGACCCCACCATCCAGCAGCTGCTGGAGCAGGCGTTGGTCATTGAGGAGCAGCTCCGGAGGGCCGCGTACCTGAACATG ACGCAGGACCCCAACCACCCCGCCATGGCCCTCAACGCCCGCCTGGCTGAAGTGGAGTGCCTCGCCGAGAGCCACCAGCACCTGTCCAAG GAGTCCCTTGCTGGGAACAAGCCTGCCAATGCCGTCCTGCACAAGGGCACGGCTACGCCCGCTGGCAGGACATCCAGAATGACCCACGGT ACATGATCCTCAACGAGCCCTTCAAGTCTGAGGTCCACAAGGGCAACTACCTGGAGATGAAGAACAAGTTCCTGGCCCGCAGGTTTAAGA GTTGCACACGCTGTGGCAGAACGAGGAGCGGGCTGCTGTATCCTCTGGGAAAATCTACGACATCTGGCACCGGCGCCATGACTACTGGCT GCTGGCGGGCATCGTGACATGACACCAAGGCTGAGGAGAAGGAGCCCATTGAAACACAGCAAAATGGTGACAAAGAGGAAGATGACGAGG GGAAGAAGGAGGACAAGAAGGGGAAATTCAAGTTCATGTTCAACATCGCGGACGGGGGCTTCACGGAGGAGGTGCTTCCTGAGAAGGAGA AGATCCTGGACAAGCTGGAGCTGAGCTTGATCCACAGCAGAGGGGACAGTTCCGAACTCAGGCCAGGCCCTTCCAGCCGCCTTGGATAGA GTGGAGAGTGAGGACAAGCACGAGAGCCCAGCCAGCAAGGAGAGAGCCCGAGAGGAGCGGCCAGAGGAGACGGAGAAGGCCCCGCCCTCC CCGGAGCAGCTGCCGAGAGACAAAATGGAAGCCCAGCTGGGCTACATGGATGAGAAAGACCCCGGGGCACAGAAGCCAAGGCAGCCCCTG GAAGTCCAGGTTCAGGAGTTTGAGCATGTCAACGGGAAGTACAGCACCCCAGACTTGATCCCTGAGGGGCCCGAGGGGAAGAAGTCGGGC GAGGTGATCTCCTCGGACCCCAACACACCAGTGCCCGCCAGCCCTGCCCACCTCCTGCCAGCCCCGCTGGGCCTGCCAGAGCCTATGTGT CCCTCTTCATGCGGCACCTGTGTGAGCCGGGGGCGGATGGTGCAGAGACCTTCGCAGACGGCGTGCCCCGGGAGGGCCTCTCCAGGCAGC ACGTGCTGACCCGCATCGGGGTCATGTCACTAGTTAGGAAGAAGGTGCTGGGCTTCAATGCCCGACAGCGGAAGGCCTTTCTGAACGCCA TCATGCGCTGGGGCATGCCCCCGCAGGACGCCTTCAACTCCCACTGGCTGGTGCGGGACCTTCGAGGGAAGAGCGAGAAGGAGTTTAGGT GGACGACGACAATCCCGGAGGCAGCTGAAGAGTGACAGGGACAAGCCCCTGCCCCCGCTTCTCGCCCGAGTTGGTGGCAACATCGAGAGT GGCAGGATGAGCTCTCTGATAACCAGTCAGAATATTCCATTGGCTCTGAGGATGAGGATGAGGACTTTGAAGAGAGGCCGGAAGGGCAGA GAGGAGGTGGAGCGGGAAATCATCAAGCAGGAGGAGAACGTGGACCCCGACTACTGGGAGAAGCTGCTGCGGCACCACTATGAGCAGCAG CAGGAGGACCTGGCCCGCAACCTGGGCAAGGGCAAGCGCATCCGCAAGCAGGTCAACTACAACGATGCCTCCCAGGAGGACCAGGGTGAC AACAAGGACGTGGAGGACAGCAGTGTGATCCACTATGACGATGCGGCCATCTCCAAGCTGCTGGACCGGAACCAGGACGCTACAGATGAC ACGGAGCTACAGAACATGAACGAGTACCTGAGCTCCTTCAAGGTGGCGCAGTACGTGGTGCGCGAGGAGGACGGCGTGGCATGATGTCTC AGGGCCAGAGGCCGGTCACACCCATCCCTGATGTCCAGTCCTCCAAAGGGGGGAACTTGGCCGCCAGTGCAAAGAAGAAGCACGGTAGCA CCCCGCCAGGCCTTCAGCCGCGCCCACCGCATCGGCCAGAACAAGAAGGTGATGATCTACCGCTTCGTGACTCGGGCCTCGGTGGAGGAG CGCATCACGCAGGTGGCCAAGCGCAAGATGATGCTCACCCACCTGGTGGTGCGGCCCGGCCTCGGCTCCAAGTCGGGGTCCATGACCAAG CAGGAGCTGGACGACATCCTCAAGTTCGGCACGGAGGAACTCTTCAAGGACGACGTGGAGGCCCCCGGGGCCCAGCAGTTCTGCTTCCTC CTCTCAACCCGGGCAGGTGGTCTGGGCATCAACCTGGCCACGGCGGACACTGTCATCATCTACGACTCGGACTGGAACCCGCACAATGAC ATCCAGATGACCAAGATGCTGGACCTCCTGGAGGACTTCCTGGAGTACGAAGGCTACAAGTATGAGCGGATTGATGGTGGCATCACCGGG GGCCTCCGGCAGGAGGCAATCGACAGATTCAATGGAGGCCCCTGTCTTGCCCAATGGCTCCTACGATGGAAGCTCCCTGGTCAAGTCTTC AGGGAAGCTCATGCTGCTACAGAAGATGCTGAAGAAACTGCGGGATGAGGGGCACCGTGTGCTCATCTTCTCCCAGGAAGTACTACAAGT TCATCCTCACACGGAACTTTGAGGCACTGAACTCCAAGGGGGGCGGGAACCAAGTATCGCTGCTCAACATCATGATGGACCTGAAAAAGT GCTGCAACCACCCCTACCTCTTCCCTGTGGCTGCCGTGCAACCTGGAGGGCTTCCTGGAGGAGTTTGCTGACATCTCCAAGGAAGACCAG ATCAAGAAGCTGCATGACCTGCTGGGGCCGCACATGCTCAGGCGGCTCAAGGCTGACGTGTTCAAGAACATGCCGGCCAAGACCGAGCTC ATTGTCCGGGTGGAGCTGAGCCAGATGCAGAATTTTTTAGGGTCTTAAACAGCTACAAGATTGATTACAAGCTGCTGCTGACAGGGACCC CCCTTCAGAACAACCTGGAGGAGCTGTTCCATCTCCTCAACTTCCTGACTCCAGAGAGGTTCAAAAAGAAGTGCAGATCAAATTCCACGT GCTGCTCACCTCCTATGAGCTCATCACCATTGACCAGGCCATCCTGGGCTCCATCGAGTGGGCCTGCCTGGTGGTAGATGAGGCCCACCG CCTCAAGAACAACCAGTCCAAGGGCCACTCCAAAGGGCCCTACCTGGTTAGCGCGCCCCTCTCCACCATCATCAACTGGGAACGCGAGTT TGAGATGTGGGCGCCCGACTTCTACGTGGTCACCTACACGGGGGACAAGGAGAGCCGCTCGGTGATTCGGGAGAACGAGTTTTCCTTTGA GGACAACGCCATTCGGAGTGGGAAGAAGGTATTCCGTATGAAGCCCACGGTCAAGTTCGACAAGCAGCCATGGTACATCGACTCCACAGG CGGCACACTGCACCCGTACCAGCTGGAGGGCCTCAACTGGCTGCGCTTCTCTTGGGCCCAGGGCACTGACACCATCCTGGCCGATGAGAT GGGTCTGGGCAAGACGGTGCAGACCATCGTGTTCCTTTACTCCCTCTACAAGGAGGGAGCTGATGCTGGGAGAAGACACCAGGCTGCCCA AGAGGCTGCTCAAGAAGGGCAAGAAGCTGAGGGACGACAAGCAGGAGAAGCCGCCGGACACGCCCATTGTGGACCTTTGACAAGAAGGGG GATGTGCACTACCTGATCAAGTGGAAAGACCTGCCCTACGACCAGTGCACCTGGGAGATCGATGACATCGACATCCCCTACTACGACAAC CTCAAGCAGGCCTACTGGGGCCACAGCTGGAGCTGTACCACACGGTGATGTATCGCAACTACCAAAGAAAGAACGACATGGATGAGCCGC CCCCCTTTGACTACGGCTCTGGGGATGAAGACGGCAAGAGCGAGAAGAGGAAGAACAAGGACCCCCTCTATGCCAAGATGGAGGAGCGCT TCTACCGCTATGGCATCAAGCCAGAGTGGATGATGATTCACCGAATCCTGAACCATAGTGCCCCCCACTGAAGGGCAAAGTCCAGCGGAT TCTACACTGGAGGTGGACGGAGCCCCCTGCCCCCTTCATGGTGGGGCTGCCGGGGCCTGACGTGGAGCCCAGCCTCCCTCCACCTAAGCC CCTGGAGGGCATCCCTGAGAGAGAGTTCTTTGTCAAGTGGGCAGGGCTGTCCTACTGGCATTGCTCCTGGGTGAAGGAGCTACAGGAGAA GGAGGGGATCCAGTGGGAGCCGAAGGACGACGACGATGAAGAGGAGGAGGGCGGCTGCGAGGAGGAGGAGGACGACCACATGGAGTTCTG CCGCGTGTGCAAGGACGGGGGCGAGCTGCTCTGCTGCGACGCCTGCCCCTCCTCCTACCACCTGCATTGCCTCAACCCGCCGCTGCCCGA GATCCCAAACGGTGAATGGCTCTGCCCGCGCTGTACTTTGATGATGGTGACGGCTATGAGACAGACCACCAGGATTACTGTGAGGTGTGC CAGCAGGGTGGGGAGATCATCCTGTGCGACACCTGCCCGAGGGCCTACCATCTCGTATGCCTGGACCCAGAGCTGGAGAAGGCTCCCGAG GGCAAGTGGAGCTGCCCCCACTGTAGTGAAGAAGATGAGAGGGAGGAGTCGGACTTCGACAGCGCCAGCATCCACAGTGCCTCCGTGCGC TCCGAATGCTCTGCAGCCCTGGGCAAGAAGAGCAAGAGGAGGCGCAAGAAGAAGAGGAGGCCTGGAGTGAGGAAGAAGATCAAAGGCTCC AAAGATGGGAAGAAAAAGGGCAAAGGGAAAAAGACGGCCGGGCTCAAGTTCCGCTTCGGGGGGATCAGCAACAAGAGGAAGAAAGGCTCC TCGGGTGGCTGCGGCTGTAGAGACGGTCACCATCTCCCCTCCGCTAGCCGTCAGCCCCCCGCAGGTGCCCCAGCCTGTGCCTATCCGCAA >2856_2856_2_AGBL5-CHD5_AGBL5_chr2_27276821_ENST00000360131_CHD5_chr1_6214829_ENST00000262450_length(amino acids)=400AA_BP= MIWPPARLEPPSTRQGRFGEPLSSPMVRPWLTFPLLPAKAGGRQVFALSLWGGGSSASRCLSPAQRILKALDSVTSGGPVAPALHSRQKR MIPGRVGWGGGSTCLGATAALGLPSARGVVKGSDSCAPARRVMGPELAQETLALPCALGCLPCPPPEVEPGCPWGPGLVPFPCPWKGLPG GFLPEAALLEGVGRVLPGGGLDPVPSADPSQPQHQGLAALFPARSALTSQNHLPTCGLLESHPLPRTLPLQVGDGDGEQVRPSLGLFVCD PSPGPRSTWKAFLSLVLGPSQGRCLGVQNPGNVRKGLREKPSWAWGGGAHGLGLSSLERACLGLRGPGLGQDSPACVADTGAIAWPSLSP -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for AGBL5-CHD5 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for AGBL5-CHD5 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for AGBL5-CHD5 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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